Low-temperature extraction device and method of active ingredients of natural products

Abstract

The invention provides a low-temperature extraction device and method of active ingredients of natural products.The low-temperature extraction device comprises a countercurrent extraction unit, an ultrasonic extraction unit, a membrane concentration unit and an enzyme adding unit, the enzyme adding unit is communicated with the countercurrent extraction unit, a residue outlet of the countercurrent extraction unit is connected with a to-be-extracted raw material feeding port of the ultrasonic extraction unit, an extract outlet of the ultrasonic extraction unit is connected with a to-be-separated liquid inlet of the membrane concentration unit, and a concentrate outlet of the membrane concentration unit is connected with a solvent inlet of the countercurrent extraction unit.Low-temperature enzymolysis technology is combined with countercurrent extraction and ultrasonic extraction, the extraction process is completed at low temperature (15-50 DEG C), extraction assisting effect of a biological active enzyme and concentration gradient increasing effect of countercurrent extraction jointly guarantee effective extraction rate of the active ingredients; ultrasonic extraction is performed on extraction residue of the natural products only, so that energy consumption is saved, recycling of the active enzyme is realized, and cost is lowered.

Description

technical field

[0001] The invention belongs to the technical field of extraction and separation of active ingredients in natural products, and relates to a low-temperature (15-50°C) extraction device and method for active ingredients in natural products, in particular to a low-temperature (15-50°C) extraction of active ingredients in traditional Chinese medicines Devices and methods. Background technique

[0002] Solvent extraction is the most commonly used method to extract active components from solid natural products such as raw materials of traditional Chinese medicine, natural plants other than traditional Chinese medicine, natural animals other than traditional Chinese medicine, natural minerals, edible fungi, etc. Different solvents can be selected according to the different active substances . Solvent extraction method can be divided into maceration method, percolation method, decoction method, reflux extraction method, continuous extraction method, etc. according ...

Examples

Embodiment 1

[0075] 200g of Xihuangcao raw material enters the countercurrent extraction equipment after being crushed, the raw material solvent ratio is 1:5, the water is preheated to 40°C and enters the countercurrent extraction equipment, the amount of cellulase added is 1g, the countercurrent extraction time is 2 hours, and the ultrasonic extraction tank is pre-installed Prepare 1000g of water and preheat it to 40°C. When residues enter the ultrasonic extraction tank, turn on the ultrasonic probe. The ultrasonic frequency is 40kHz. After 10 minutes, take out the extract at the bottom of the ultrasonic extraction equipment, filter and centrifuge to remove suspended particles, and then proceed. Pressurize to 3.0MPa and enter the membrane module. The reverse osmosis membrane with high interception performance for the active ingredients of Xihuangcao is selected in the membrane module. Under the pressure drive, the water passes through the separation membrane, and the active enzymes in the ...

Embodiment 2

[0079] 200g of Bletilla striata raw material is crushed and enters the countercurrent extraction equipment. The raw material solvent ratio is 1:5. The water is preheated to 40°C and enters the countercurrent extraction equipment. The total amount of cellulase and pectinase is 1g, the countercurrent extraction time is 2 hours, and ultrasonic extraction The tank is pre-filled with 1000g of water and preheated to 40°C. When residue enters the ultrasonic extraction tank, turn on the ultrasonic probe. The ultrasonic frequency is 40kHz. After 10 minutes, take out the extract at the bottom of the ultrasonic extraction equipment, and remove the suspension by filtration and centrifugation. The particles go backward and are pressurized to 3.0MPa to enter the membrane module. In the membrane module, the reverse osmosis membrane with high interception performance for the active ingredients of Xihuangcao is selected. Under the pressure drive, the water passes through the separation membrane...

Embodiment 3

[0083] 200g ganoderma lucidum raw material enters the countercurrent extraction equipment after being crushed, the raw material solvent ratio is 1:6, the water is preheated to 50°C and enters the countercurrent extraction equipment, the total addition of cellulase, pectinase and papain is 1.2g, and the countercurrent extraction time is 2 hour, the ultrasonic extraction tank is pre-filled with 1200g of water, preheated to 50°C, when residue enters the ultrasonic extraction tank, the ultrasonic probe is turned on, the ultrasonic frequency is 40kHz, and after 10 minutes, the extraction solution is taken out at the bottom of the ultrasonic extraction equipment and passed through After filtering and centrifuging to remove suspended particles, pressurize to 3.0MPa and enter the membrane module. The reverse osmosis membrane with high interception performance for the active ingredients of Ganoderma lucidum is selected in the membrane module. Under the pressure drive, the water passes t...

technical field

[0001] The invention belongs to the technical field of extraction and separation of active ingredients in natural products, and relates to a low-temperature (15-50°C) extraction device and method for active ingredients in natural products, in particular to a low-temperature (15-50°C) extraction of active ingredients in traditional Chinese medicines Devices and methods. Background technique

[0002] Solvent extraction is the most commonly used method to extract active components from solid natural products such as raw materials of traditional Chinese medicine, natural plants other than traditional Chinese medicine, natural animals other than traditional Chinese medicine, natural minerals, edible fungi, etc. Different solvents can be selected according to the different active substances . Solvent extraction method can be divided into maceration method, percolation method, decoction method, reflux extraction method, continuous extraction method, etc. according ...

Examples

Embodiment 1

[0075] 200g of Xihuangcao raw material enters the countercurrent extraction equipment after being crushed, the raw material solvent ratio is 1:5, the water is preheated to 40°C and enters the countercurrent extraction equipment, the amount of cellulase added is 1g, the countercurrent extraction time is 2 hours, and the ultrasonic extraction tank is pre-installed Prepare 1000g of water and preheat it to 40°C. When residues enter the ultrasonic extraction tank, turn on the ultrasonic probe. The ultrasonic frequency is 40kHz. After 10 minutes, take out the extract at the bottom of the ultrasonic extraction equipment, filter and centrifuge to remove suspended particles, and then proceed. Pressurize to 3.0MPa and enter the membrane module. The reverse osmosis membrane with high interception performance for the active ingredients of Xihuangcao is selected in the membrane module. Under the pressure drive, the water passes through the separation membrane, and the active enzymes in the ...

Embodiment 2

[0079] 200g of Bletilla striata raw material is crushed and enters the countercurrent extraction equipment. The raw material solvent ratio is 1:5. The water is preheated to 40°C and enters the countercurrent extraction equipment. The total amount of cellulase and pectinase is 1g, the countercurrent extraction time is 2 hours, and ultrasonic extraction The tank is pre-filled with 1000g of water and preheated to 40°C. When residue enters the ultrasonic extraction tank, turn on the ultrasonic probe. The ultrasonic frequency is 40kHz. After 10 minutes, take out the extract at the bottom of the ultrasonic extraction equipment, and remove the suspension by filtration and centrifugation. The particles go backward and are pressurized to 3.0MPa to enter the membrane module. In the membrane module, the reverse osmosis membrane with high interception performance for the active ingredients of Xihuangcao is selected. Under the pressure drive, the water passes through the separation membrane...

Embodiment 3

[0083] 200g ganoderma lucidum raw material enters the countercurrent extraction equipment after being crushed, the raw material solvent ratio is 1:6, the water is preheated to 50°C and enters the countercurrent extraction equipment, the total addition of cellulase, pectinase and papain is 1.2g, and the countercurrent extraction time is 2 hour, the ultrasonic extraction tank is pre-filled with 1200g of water, preheated to 50°C, when residue enters the ultrasonic extraction tank, the ultrasonic probe is turned on, the ultrasonic frequency is 40kHz, and after 10 minutes, the extraction solution is taken out at the bottom of the ultrasonic extraction equipment and passed through After filtering and centrifuging to remove suspended particles, pressurize to 3.0MPa and enter the membrane module. The reverse osmosis membrane with high interception performance for the active ingredients of Ganoderma lucidum is selected in the membrane module. Under the pressure drive, the water passes t...

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