A kind of composite seaweed polysaccharide hypolipidemic oral liquid and preparation method thereof

Abstract

The invention discloses composite seaweed polysaccharide oral liquid for reducing blood lipid and a preparation method of the composite seaweed polysaccharide oral liquid. The composite seaweed polysaccharide oral liquid for reducing blood lipid is prepared from the following components in percentage by mass: 60-90% of a seaweed polysaccharide extract, 1-10% of a haw extract, 1-10% of a lotus leaf extract, 1-10% of a ginkgo leaf extract, 1-10% of a mulberry leaf extract and 0.01-10% of a sweetening agent, wherein the seaweed polysaccharide extract is obtained through extraction with high-pressure steam. The preparation method comprises the following steps of mixing the components in percentage by mass to obtain a mixture, performing cold storage on the mixture, performing centrifugation to obtain a supernatant, performing filling, performing covering, and performing sterilization so as to obtain the composite seaweed polysaccharide oral liquid for reducing blood lipid. According to the composite seaweed polysaccharide oral liquid and the preparation method thereof disclosed by the invention, polysaccharide and polyphenol substances having the efficacy of reducing blood lipid are in synergy and are compounded, the preparation method is simple in steps, the synergistic interaction of seaweed polysaccharides and polyphenols is used for strengthening the efficacy of the seaweed polysaccharides for reducing blood lipid, and the purpose of enhancing the efficacy of the finished products for reducing blood lipid can be achieved.

Description

technical field

[0001] The invention relates to the technical field of processing and utilization of seaweed polysaccharides, in particular to a compound seaweed polysaccharide hypolipidemic oral liquid and a preparation method thereof. Background technique

[0002] A large number of studies have shown that seaweed polysaccharides contain special groups such as sulfate groups and uronic acids, so they have a variety of special physiological functions, such as anti-virus, anti-coagulation, hypoglycemic, and hypolipidemic activities. Seaweed polysaccharides have great potential in the development of functional foods due to their unique biological activities. However, its molecular weight is large, and most of them have strong gelation or high viscosity, which limits their clinical application to a certain extent. Aiming at the problems of excessive molecular weight, high viscosity, and poor solubility of high-molecular seaweed polysaccharides, high-molecular seaweed polysacch...

Examples

Embodiment 1

[0044] (1) Take 1 catties of commercially available dried kelp, wash it, dry it and crush it to get 200g of kelp powder; mix the kelp powder and water at a mass ratio of 1:20, heat and extract with 125°C steam at 100kPa for 0.5 hours, and centrifuge at 8000rpm 10 minutes to obtain the supernatant; the supernatant was separated by a 500K ultrafiltration membrane with a molecular weight cut-off, and the components with a molecular weight below 500KDa were collected;

[0045] (2) Concentrate the collected components to a solid content of 4%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 60vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:10 and depressurize The alcohol was removed by evaporation to obtain a seaweed polysaccharide extract with a final polysaccharide content of 6.0 mg / mL, a reducing sugar content of 1.0 mg / mL, and a pH of 6.5;

[0046] (3) Take the dried hawt...

Embodiment 2

[0049] (1) Take 1 jin of commercially available dried undaria pinnatae, wash, dry and pulverize to obtain 200 g wakame powder; mix wakame powder and water at a mass ratio of 1:50, heat and extract with 100°C steam at 100kPa for 2 hours, Centrifuge at 8000rpm for 10 minutes to obtain a supernatant; the supernatant is separated by an ultrafiltration membrane with a molecular weight cut-off of 500K, and components with a molecular weight below 500KDa are collected;

[0050] (2) Concentrate the collected components to a solid content of 10%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 90vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:30 and reduce pressure Evaporate and remove the alcohol to obtain a seaweed polysaccharide extract with a final polysaccharide content of 2.0 mg / mL, a reducing sugar content of 0.5 mg / mL, and a pH of 6.0;

[0051] (3) Take the dried hawthor...

Embodiment 3

[0054] (1) Take 1 catties of commercially available dry kelp, wash it, dry it and crush it to get 200g kelp powder; mix the kelp powder and water at a mass ratio of 1:40, heat and extract with steam at 110°C under 100kPa for 1 hour, and centrifuge at 8000rpm 10 minutes to obtain the supernatant; the supernatant was separated by a 500K ultrafiltration membrane with a molecular weight cut-off, and the components with a molecular weight below 500KDa were collected;

[0055] (2) Concentrate the collected components to a solid content of 6%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 80vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:20 and reduce pressure The alcohol was removed by evaporation to obtain a seaweed polysaccharide extract with a final polysaccharide content of 4.0 mg / mL, a reducing sugar content of 0.8 mg / mL, and a pH of 6.2;

[0056] (3) Take the dried haw...

technical field

[0001] The invention relates to the technical field of processing and utilization of seaweed polysaccharides, in particular to a compound seaweed polysaccharide hypolipidemic oral liquid and a preparation method thereof. Background technique

[0002] A large number of studies have shown that seaweed polysaccharides contain special groups such as sulfate groups and uronic acids, so they have a variety of special physiological functions, such as anti-virus, anti-coagulation, hypoglycemic, and hypolipidemic activities. Seaweed polysaccharides have great potential in the development of functional foods due to their unique biological activities. However, its molecular weight is large, and most of them have strong gelation or high viscosity, which limits their clinical application to a certain extent. Aiming at the problems of excessive molecular weight, high viscosity, and poor solubility of high-molecular seaweed polysaccharides, high-molecular seaweed polysacch...

Examples

Embodiment 1

[0044] (1) Take 1 catties of commercially available dried kelp, wash it, dry it and crush it to get 200g of kelp powder; mix the kelp powder and water at a mass ratio of 1:20, heat and extract with 125°C steam at 100kPa for 0.5 hours, and centrifuge at 8000rpm 10 minutes to obtain the supernatant; the supernatant was separated by a 500K ultrafiltration membrane with a molecular weight cut-off, and the components with a molecular weight below 500KDa were collected;

[0045] (2) Concentrate the collected components to a solid content of 4%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 60vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:10 and depressurize The alcohol was removed by evaporation to obtain a seaweed polysaccharide extract with a final polysaccharide content of 6.0 mg / mL, a reducing sugar content of 1.0 mg / mL, and a pH of 6.5;

[0046] (3) Take the dried hawt...

Embodiment 2

[0049] (1) Take 1 jin of commercially available dried undaria pinnatae, wash, dry and pulverize to obtain 200 g wakame powder; mix wakame powder and water at a mass ratio of 1:50, heat and extract with 100°C steam at 100kPa for 2 hours, Centrifuge at 8000rpm for 10 minutes to obtain a supernatant; the supernatant is separated by an ultrafiltration membrane with a molecular weight cut-off of 500K, and components with a molecular weight below 500KDa are collected;

[0050] (2) Concentrate the collected components to a solid content of 10%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 90vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:30 and reduce pressure Evaporate and remove the alcohol to obtain a seaweed polysaccharide extract with a final polysaccharide content of 2.0 mg / mL, a reducing sugar content of 0.5 mg / mL, and a pH of 6.0;

[0051] (3) Take the dried hawthor...

Embodiment 3

[0054] (1) Take 1 catties of commercially available dry kelp, wash it, dry it and crush it to get 200g kelp powder; mix the kelp powder and water at a mass ratio of 1:40, heat and extract with steam at 110°C under 100kPa for 1 hour, and centrifuge at 8000rpm 10 minutes to obtain the supernatant; the supernatant was separated by a 500K ultrafiltration membrane with a molecular weight cut-off, and the components with a molecular weight below 500KDa were collected;

[0055] (2) Concentrate the collected components to a solid content of 6%, add edible alcohol to the concentrated solution until the final concentration of alcohol is 80vol%, refrigerate at 4°C for 12 hours, centrifuge to obtain a precipitate, add water to dissolve at a ratio of 1:20 and reduce pressure The alcohol was removed by evaporation to obtain a seaweed polysaccharide extract with a final polysaccharide content of 4.0 mg / mL, a reducing sugar content of 0.8 mg / mL, and a pH of 6.2;

[0056] (3) Take the dried haw...

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