An abnormal infusion state detection and control system based on microfluidic pump

Abstract

The present invention provides an abnormal infusion state detection and control system based on a microfluidic pump, comprising: a microfluidic pump chip, which outputs liquid by controlling the vibration of an actuator; a pressure sensor, which is located in a pipeline behind the output port of the microfluidic pump chip, and outputs an electrical signal by sensing the pressure change of the liquid output by the microfluidic pump chip; a signal conditioning circuit, which is used to condition the electrical signal to obtain a conditioned electrical signal; a signal acquisition circuit, which is used to convert the conditioned electrical signal from an analog signal to a digital signal; a signal processing unit, which is used to judge the working state of the microfluidic pump chip and the infusion pipeline according to the digital signal, and send a signal to an alarm unit when an abnormality is found; an alarm unit, which is used to send an alarm according to the signal; and a control drive unit, which is used to adjust the output state of the microfluidic pump chip according to the output of the signal processing unit. The present invention can accurately control the microfluidic pump chip, accurately detect the abnormal state of the microfluidic pump chip and give an alarm in time.

Description

Technical Field

[0001] The present invention relates to the fields of medical treatment, biology, chemistry, agriculture, cosmetology and sanitary ware, and in particular to an abnormal infusion state detection and control system based on a microfluidic pump. Background Art

[0002] As an important part of microfluidic technology, microfluidic pump chips have broad prospects in medical applications, biology, chemistry, agriculture, beauty, and sanitary ware due to their simple structure, thin and light volume, low-frequency operation, and low power consumption. In actual work, the matching abnormal detection and control system is a very important part of the entire system. Especially in applications with high requirements for safety and stability, all states of the equipment must be monitored during operation to prevent potential risks caused by abnormal states such as pipeline blockage, empty reservoir, pump chip failure, bubble retention, and liquid leakage.

[0003] At present, most electronic syringe pumps on the market use a mechanical structure and use piston propulsion to deliver liquids. The different working states of the electronic syringe pump can be judged by detecting the resistance of the push rod. However, due to the existence of piston resistance, this method is not very sensitive and will impose a large cumulative pressure on the liquid path. At the moment of blockage removal, a large dose of liquid may be infused in a short time, which poses certain safety risks.

[0004] In addition, there are microfluidic pump chips based on silicon-based MEMS technology that have integrated pressure sensors. This solution solves the sensitivity problem. However, the pressure sensor integrated in the chip detects the pressure changes in the pipelines inside the chip, and infusion abnormalities may also occur in the pipelines outside the chip. It is not enough to simply detect the pressure changes in the pipelines inside the chip. Different external pipeline designs and even the shaking of the infusion hose may affect the test accuracy. Therefore, this solution cannot accurately detect the abnormal infusion status of the entire system. Summary of the invention

[0005] In view of the shortcomings of the existing microfluidic pump system in abnormal detection and precise control, the present invention provides an abnormal infusion state detection and control system based on a microfluidic pump. The scheme of the present invention can monitor the working state of the microfluidic pump chip and the delivery pipeline in real time. When an abnormality is found, the operation of the microfluidic pump chip is stopped or adjusted and an alarm is issued in time.

[0006] The abnormal infusion state detection and control system based on the microfluidic pump of the present invention comprises:

[0007] Microfluidic pump chip, which controls the vibration of the actuator to output liquid;

[0008] A pressure sensor is located in the pipeline behind the output port of the microfluidic pump chip, and outputs an electrical signal by sensing the pressure change of the liquid output by the microfluidic pump;

[0009] A signal conditioning circuit, used for performing signal conditioning on the electrical signal to obtain a conditioned electrical signal;

[0010] A signal acquisition circuit, used for converting the conditioned electrical signal from an analog signal to a digital signal;

[0011] A signal processing unit, used to determine the working status of the microfluidic pump chip and the infusion pipeline according to the digital signal, and send a signal to an alarm unit when an abnormality is found;

[0012] an alarm unit, configured to issue an alarm according to the signal; and

[0013] A control driving unit is used to adjust the output state of the microfluidic pump chip according to the output of the signal processing unit.

[0014] Preferably, the microfluidic pump chip further comprises an actuator, a pump chamber, a connecting mechanism, an inlet valve and an outlet valve, the pump chamber is for liquid to pass through, and the actuator serves as a driving source.

[0015] Preferably, the pressure sensor is composed of a pressure-sensitive material, a barrier layer, an upper cover, a bottom cover and a sensing chamber.

[0016] Preferably, the pressure sensor is installed in a separate chamber, or integrated into the delivery pipeline to become a part of the pipeline.

[0017] Preferably, a plurality of pressure sensors can be integrated and located before the input port of the microfluidic chip, in the microfluidic pump chip, and after the output port of the microfluidic pump chip, so as to monitor the entire fluid circuit.

[0018] Preferably, the signal processing unit further includes an analysis module, a judgment module and an output module. The analysis module analyzes the digital signal to obtain the liquid pressure value reflected by the electrical signal. The judgment module determines the working state of the microfluidic pump chip and the infusion pipeline according to the pressure value. When an abnormality is found, the output module outputs a signal to the alarm unit. The abnormality includes pipeline blockage, empty reservoir, pump chip failure, bubble retention and liquid leakage.

[0019] Preferably, the alarm modes of the alarm unit include screen alarm, light alarm, vibration alarm and sound alarm.

[0020] Preferably, the alarm unit further comprises a wireless transmission module.

[0021] Preferably, it further comprises a noise filtering module for filtering out motion noise interference.

[0022] Preferably, the control driving unit adjusts the parameters of the driving signal output to the microfluidic pump chip according to the output of the signal processing module, and the parameters include a driving signal voltage value, a driving signal frequency and a driving signal duty cycle.

[0023] The present invention has the following beneficial effects: through the abnormal state detection and control system of the present invention, the microfluidic pump chip can be precisely controlled, and its abnormal state can be accurately detected and alarmed in time. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a structural schematic diagram of an abnormal infusion state detection and control system based on a microfluidic pump according to an embodiment of the present invention.

[0025] Figure 2 It is a schematic structural diagram of a microfluidic pump according to an embodiment of the present invention.

[0026] Figure 3 Schematic diagram of the structure of a pressure sensor according to an embodiment of the present invention.

[0027] Figure 4 It is a structural schematic diagram of a signal processing unit according to an embodiment of the present invention.

[0028] Figure 5 It is a structural block diagram of a drive control unit according to an embodiment of the present invention.

[0029] Figure 6 It is a structural schematic diagram of an alarm unit according to an embodiment of the present invention.

[0030] FIG. 7( a ), FIG. 7 ( b ), and FIG. 7 ( c ) are waveform diagrams of noise filtered out by three noise filtering modules of the present invention. DETAILED DESCRIPTION

[0031] The present invention is further described below by way of examples, the purpose of which is only to provide a better understanding of the research content of the present invention rather than to limit the protection scope of the present invention.

[0032] The structure of the abnormal infusion state detection and control system based on the microfluidic pump of the present invention is described in detail below with reference to the accompanying drawings.

[0033] like Figure 1 As shown, an abnormal infusion state detection and control system based on a microfluidic pump according to an embodiment of the present invention comprises a microfluidic pump chip 1, a pressure sensor 2, a signal conditioning circuit 3, a signal acquisition circuit 4, a signal processing unit 5, a control drive unit 6 and an alarm unit 7. Each part is described in detail below.

[0034] The microfluidic pump chip 1 controls the vibration of the actuator to output liquid. The structure of the microfluidic pump chip 1 is as follows: Figure 2 As shown, it is mainly composed of an actuator 11, a pump chamber 14, a connecting mechanism 15, an inlet valve 12 and an outlet valve 13. The microfluidic pump chip 1 uses the actuator 11 as a driving source, and generates vibration under the driving signal output by the control drive unit 6. The actuator includes but is not limited to piezoelectric ceramics, magnetostrictive devices, thermostrictive devices, and shape memory alloys. The microfluidic pump chip 1 is connected to the control drive unit 6 through a wire group 1a. When the driving signal generated by the control drive unit 6 is loaded on the microfluidic pump chip 1, the actuator 11 generates vibrations, and the volume of the pump chamber 14 is directly or indirectly changed through the connecting mechanism 15. At the same time, the inlet valve 12 and the outlet valve 13 are alternately opened and closed to output liquid. The arrow in the figure indicates the flow direction of the liquid, and the pump chamber 14 is used for liquid circulation.

[0035] The pressure sensor 2 is installed behind the output port of the microfluidic pump chip 1 and connected via the pipeline 3a. The structure of the pressure sensor 2 is as follows: Figure 3 As shown, it is mainly composed of a pressure-sensitive material 21, a barrier layer 22, an upper cover 23, a bottom cover 24 and a sensing chamber 25. The liquid is output from the microfluidic pump chip 1 and flows to the pressure sensor 2 through the pipeline 3a. The pipeline 3a is a specially designed flow channel that can reduce or eliminate the interference of the liquid by the outside world and due to sudden changes in resistance. This part of the design includes but is not limited to special capillary channels, fluid resistance devices and pressure smoothing devices. The pressure sensor 2 is connected to the pipeline 3a. When the liquid flows through the sensing chamber 25, the change in liquid pressure acts on the pressure-sensitive material 21 through the barrier layer 22. The barrier layer 22 is a flexible material that can isolate the liquid and produce a small deformation in response to the liquid pressure to transmit the pressure to the pressure-sensitive material 21. The pressure-sensitive material 21 is a special material. When it undergoes mechanical deformation, such as extrusion, stretching, shearing, torsion, etc., its electrical properties will change. The electrical properties include but are not limited to resistance, capacitance, inductance, charge, etc. The pressure-sensitive material 21 of the pressure sensor 2 includes but is not limited to piezoresistors, piezoelectric materials, etc. When the pressure-sensitive material 21 senses pressure, its electrical properties change. At the same time, since the bottom cover 24 is made of rigid material, the size of the sensing chamber 25 will not change significantly under different pressures, so the pressure acting on the pressure-sensitive material 21 can accurately reflect the pressure inside the liquid. The pressure-sensitive material 21 senses the change in the volume of the output liquid of the microfluidic pump chip 1 and outputs an electrical signal. The pressure sensor 2 and the signal conditioning circuit 3 are connected through the wire group 2a, so that the output signal is transmitted to the signal conditioning circuit 3.

[0036] As described above, the microfluidic pump chip 1 transports liquid based on pressure difference. Under the action of the driving signal, the pump chamber 14 expands and contracts alternately, and the inlet valve 12 and the outlet valve 13 are opened and closed alternately, and the liquid is transported under the change of pressure. Therefore, the change of the internal pressure value of the liquid can reflect the different states of the microfluidic pump chip.

[0037] The signal conditioning circuit 3 is used to convert, amplify, filter, and impedance match the changing electrical properties of the pressure sensor 2 to obtain a conditioned electrical signal. The pressure sensor 2 is based on the change in electrical properties of the pressure-sensitive material 21 under pressure. The first step is to convert the change in its electrical properties into a change in a voltage signal through a conversion circuit. The resistance value of the varistor will change under the action of pressure, and its conversion circuit uses the Whittens bridge method to convert the change in resistance value into a change in voltage signal. In addition, the varistor can also be directly used as one of the resistors in the operational amplifier circuit to achieve the integration of amplification and voltage conversion. In other embodiments, the pressure-sensitive material can be a piezoelectric material. When the pressure changes, the output signal of the piezoelectric material is directly a voltage signal, so there is no need for a corresponding conversion circuit.

[0038] The pressure sensor 2 of the present invention can also be an optical pressure sensor. The main principle of the optical pressure sensor is that pressure acts on an optical fiber or a grating, causing the refraction of light to deflect or the light intensity to change, and then the optical signal is converted into an electrical signal through a photosensitive material to obtain a pressure value. In this case, a corresponding conversion circuit is not required.

[0039] The voltage signal is often a tiny signal, which needs to be amplified by a signal amplifier circuit to reach the range of the back-end signal acquisition circuit. The signal filter circuit is mainly used to filter out noise and only allow signals at a certain operating frequency to pass. The impedance matching circuit is used to match the output impedance of the sensor and the input impedance of the back-end signal acquisition circuit to prevent signal distortion. The signal conditioning circuit 3 can use any known circuit that performs a signal conditioning function.

[0040] The signal acquisition circuit 4 is used to convert the conditioned electrical signal from an analog signal to a digital signal. Specifically, the signal acquisition circuit is, for example, an A / D converter.

[0041] The signal processing unit 5 is used to determine the working state of the microfluidic pump chip and the infusion pipeline according to the digital signal output by the signal acquisition circuit 4, and to control the microfluidic pump chip to adjust its output characteristics by adjusting the drive voltage, drive waveform frequency, waveform duty cycle, etc. through the drive control unit 6. When a fault or abnormality is found, such as blockage or pump failure, the entire microfluidic pump chip is adjusted or stopped, and an alarm is sounded. Specifically, Figure 4As shown, the signal processing unit 5 further includes an analysis module 51 , a judgment module 52 and an output module 53 .

[0042] The analysis module 51 analyzes the digital signal through an algorithm to obtain the liquid pressure value reflected by the electrical signal. Those skilled in the art may use known algorithms or methods to perform the above analysis steps.

[0043] The judgment module 52 judges which working state the pressure value corresponds to. The microfluidic pump chip 1 is a chip for quantitatively and regularly outputting fluid. During the process of the liquid passing through the pipeline and being infused, its pressure change is a regular pressure change curve. Therefore, the characteristic value of the pressure value changing with time can correspond to the working state of the microfluidic pump chip and the pipeline, as follows.

[0044] When the pipeline is blocked, each operation of the pump chip will cause an increase in pressure, but the pressure decay curve slows down significantly, and when analyzing its static pressure, the pressure continues to increase.

[0045] When the reservoir is emptied, negative pressure will be generated in the reservoir part, which will offset the pressure at the output of the microfluidic pump chip. The pressure signal will reflect a gradually decreasing trend until it finally becomes a very small dynamic pressure signal.

[0046] When the pump chip fails, the pressure sensor cannot sense the pressure changes generated each time the microfluidic pump chip works, and the pressure signal reflects an unchanging straight line signal.

[0047] When bubbles are retained, the pressure value will change less than that during normal operation, and the frequency component characteristics of the pressure value will also be different, because the compressibility of air is much higher than that of liquid. At the same time, considering that there is an air exhaust process in the early stage of system operation, a certain time window must be set for monitoring this state. When bubbles are discharged within a certain time window, they are not marked as retained bubbles. Only when the situation lasts longer than the time window will the alarm be triggered.

[0048] When liquid leaks, the static pressure value drops slowly. At the same time, the dynamic pressure change caused by the pump chip outputting liquid will also drop quickly. Moreover, the trend of dynamic pressure change will be different when liquid leaks at different locations.

[0049] In addition, one problem with using a pressure sensor as an abnormality detection sensor is external motion interference. When the system needs to move or work on a moving object, external vibrations will also be reflected in the pressure change. The system cannot distinguish whether the pressure change is caused by changes in the working state of the liquid pipeline and the pump body or external interference. This problem is a difficulty in using the pressure sensor solution. In this system, a noise filtering module is also included to filter out motion noise interference.

[0050] In one embodiment, the noise filtering module can use the closed-loop control principle to filter out motion noise. Specifically, the signal of the microfluidic pump closed-loop system is sent to the drive control unit by the signal processing unit. At the same time, the signal is also used as a reference signal for filtering out motion noise. The signal collected by the pressure sensor and the reference signal are combined, and only the pressure signal when the reference signal is valid is focused on. In this way, only the pressure signal generated when the pump chip is working is analyzed, and the rest of the noise signals are filtered out, as shown in Figure 7 (a).

[0051] In another embodiment, the noise filtering module can also use a motion sensor to filter out motion noise. The motion sensor is integrated in the system. The signal collected by the motion sensor is processed and normalized and then subtracted from the signal collected by the pressure sensor. In this way, the interference signal caused by external motion in the pressure signal is subtracted, and the remaining signal is the pressure signal generated when the pump chip is working, as shown in Figure 7 (b).

[0052] In another embodiment, the noise filtering module can also adopt a dual pressure sensor solution. Two pressure sensors are placed at different positions of the pipeline. Because the relative positions of the two pressure sensors are fixed, the transmission time difference of the pressure signal generated by the pump chip in the pipeline is fixed, so this signal has a fixed phase difference on the two pressure sensors. The interference signal generated by the motion affects the two pressure sensors at the same time, so the interference signal does not have this fixed phase difference, so the pressure signal generated by the pump chip can be extracted by a simple signal processing method, as shown in Figure 7 (c).

[0053] The above three implementation modes may be used simultaneously, or one or two of them may be used.

[0054] The output module 53 outputs a signal according to the judgment result. The output signal mainly includes a DO signal, an Enable signal and a Sig (driving waveform) signal. Among them, the DO signal is used to adjust the driving signal voltage value, the Enable signal is used to switch the driving circuit, and the Sig signal is used to adjust the shape, frequency value and duty cycle of the driving signal.

[0055] The control driving unit 6 is used to adjust the driving signal output to the microfluidic pump chip 1 according to the output signal to control the output state of the microfluidic pump chip 1. The control driving unit 6 mainly controls three parameters of the driving signal, which are the driving signal voltage value, the driving signal frequency, and the driving signal duty cycle, as mentioned above, and the output state of the microfluidic pump chip 1 is controlled in real time through these three parameters.

[0056] The structural diagram of the control drive unit 6 is as follows: Figure 5 As shown, the control driving unit 6 includes a high voltage driving circuit 61, a boost power supply 62, a resistor voltage divider network 63, and an enabling switch 64. Figure 5 The three parameters of the driving signal are controlled according to the three groups of output signals of the signal processing unit.

[0057] The amplitude value of the driving signal is adjusted as follows. The DO signal 55 of the signal processing unit 5 adjusts the resistor voltage divider network, mainly through two methods: the first is to use an adjustable resistor, and the DO signal directly controls the resistance value of the adjustable resistor. The second is to output an adjustable voltage, which replaces the signal ground as the reference voltage of the resistor voltage divider network 63. These two methods can be used alone or in combination to achieve finer-grained control. By adjusting the voltage divider resistor network 63, the output voltage of the boost power supply 62 is adjusted through the feedback circuit inside the boost power supply 62, and finally the driving signal amplitude value is controlled.

[0058] The signal processing unit 5 is connected to the enable switch 64 through the Enable signal 58 to control the enablement of the boost power supply 62 and the high-voltage drive circuit 61. Specifically, the Enable signal controls the enable switch 64. When the Enable signal mark is turned off, the boost circuit and the high-voltage drive circuit stop working, so that the output signal is 0 level. When the Enable signal mark is turned on, the boost circuit and the high-voltage drive circuit work normally.

[0059] The Sig signal 56 of the signal processing unit 5 controls the frequency and duty cycle of the drive signal. The Sig signal is an input reference signal for controlling the drive unit 6, which determines the signal frequency and duty cycle of the output signal High Voltage Out+ / - 65. The Sig signal can support any waveform, including but not limited to square wave, triangle wave, sine wave, etc.

[0060] The output signal High Voltage Out+ / - 67 is a pair of signals connected to the actuator of the microfluidic pump chip 1. In this example, the output signal is a pair of homologous signals with a phase difference of 180 degrees. The generation method of this group of signals is as follows: the single-ended Sig signal is first divided into two, one of which is connected to the inverter 65, so that the single-ended Sig signal becomes a pair of signals Input+ / - 66 with a phase difference of 180 degrees. When the actuator of the microfluidic pump chip is connected to High Voltage Out+ and HighVoltage Out-, it can support positive level-negative level output. When the actuator of the microfluidic pump chip is connected to HighVoltage Out+ and the ground signal, it can support positive level-ground output.

[0061] At the same time, High Voltage Out+ / - 67 can also support asymmetric signals with arbitrary phase differences. At this time, the Sig signal changes from a single-ended signal to a double-ended signal. The waveform, phase, and amplitude of each signal can be adjusted according to actual needs, thereby realizing the output of arbitrary drive waveforms in the output signal High Voltage Out+ / - 67, thereby achieving more flexible control of the actuator devices of the microfluidic pump chip.

[0062] The amplitude value of the driving signal can control the vibration degree of the actuator 11 of the microfluidic pump chip 1, thereby changing the output pressure and flow of the microfluidic pump chip 1. The frequency of the driving signal corresponds to the number of times the actuator 11 works per unit time. The signal duty cycle corresponds to the time ratio of the microfluidic pump chip 1 working and non-working. According to the information transmitted by the signal processing unit 5, the control driving unit 6 adjusts any one or more of the three parameters to control the output state of the microfluidic pump chip 1 in real time.

[0063] When the signal processing unit 5 determines that an abnormality occurs, that is, when the microfluidic pump chip or the delivery pipeline is in an abnormal state, the alarm unit 7 issues an alarm. The alarm mode includes but is not limited to: vibration alarm, sound alarm, light alarm, and abnormal information displayed on the LCD screen. At the same time, the control terminal is sent through the wireless transmission module 71, and an alarm is issued in the control terminal at the same time. It can also be sent to the Internet through the wireless transmission module to achieve remote alarm.

[0064] In addition, this system can also realize certain troubleshooting functions as a closed-loop control. When an abnormality is detected, the signal processing unit can adjust three parameters to change the working state of the pump chip, thereby realizing the troubleshooting function. Their specific implementation methods are as follows:

[0065] When a blockage is detected, first increase the amplitude of the drive signal to increase the output pressure of the pump chip. If the pressure sensor detects that the liquid pressure first increases and then continues to decrease, it indicates that the blockage is now cleared and the output pressure returns to the rated value. If it does not decrease, continue to increase the amplitude of the drive signal until the blockage is cleared. If blockage is still detected at the highest amplitude value, it indicates that the troubleshooting has failed.

[0066] When bubbles are detected, the drive signal amplitude and drive signal frequency can be increased simultaneously. At this time, the output flow of the pump chip increases, accelerating the movement of the liquid to push the bubbles so that they can be discharged.

[0067] Obviously, those skilled in the art should realize that the above embodiments are only used to illustrate the present invention, and are not used to limit the present invention. As long as they are within the spirit of the present invention, any changes or modifications to the above embodiments will fall within the scope of the claims of the present invention.

Claims

1. An abnormal infusion state detection and control system based on a microfluidic pump, characterized in that: include: Microfluidic pump chip, which controls the vibration of the actuator to output liquid; The pressure sensor is located in the pipeline behind the output port of the microfluidic pump chip, and outputs an electrical signal by sensing the pressure change of the liquid output by the microfluidic pump; the pressure sensor is composed of an upper cover, a pressure-sensitive material, a barrier layer, a sensing chamber and a bottom cover from top to bottom; the sensing chamber is formed by the lower surface of the barrier layer and the upper surface of the bottom cover for the liquid output by the microfluidic pump to pass through; the barrier layer is a flexible material that can isolate the liquid and produce a slight deformation in response to the liquid pressure to transmit the pressure to the pressure-sensitive material; A signal conditioning circuit, used for conditioning the electrical signal to obtain a conditioned electrical signal; A signal acquisition circuit, used for converting the conditioned electrical signal from an analog signal to a digital signal; A signal processing unit, used to judge the working state of the microfluidic pump chip and the infusion pipeline according to the digital signal, the signal processing unit further comprises an analysis module, a judgment module and an output module, the analysis module analyzes the digital signal to obtain the liquid pressure value reflected by the electrical signal, the judgment module judges the working state of the microfluidic pump chip and the infusion pipeline according to the pressure value, and when the working state is found to be abnormal, the output module sends a signal to the alarm unit; the abnormal working state includes pipeline blockage, empty reservoir, pump chip failure, bubble retention and liquid leakage; An alarm unit, used for issuing an alarm according to the signal; as well as a control driving unit, used to adjust the output state of the microfluidic pump chip according to the output of the signal processing unit, The signal processing unit further includes a noise filtering module for filtering out motion noise interference. The noise filtering module adopts a dual pressure sensor solution, and two pressure sensors are placed at different positions of the pipeline.

2. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 1, characterized in that: The microfluidic pump chip further comprises an actuator, a pump chamber, a connecting mechanism, an inlet valve and an outlet valve, the pump chamber is for liquid to pass through, and the actuator serves as a driving source.

3. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 2, characterized in that: The pressure sensor is connected to the microfluidic pump chip through a pipeline, and the pipeline is a specially designed flow channel that can reduce or eliminate the interference of the liquid caused by the outside world and sudden changes in resistance.

4. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 1, characterized in that: The pressure sensor is installed in a separate chamber, or integrated into the conveying pipeline to become a part of the pipeline.

5. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 1, characterized in that: Multiple pressure sensors are integrated and located before the input port of the microfluidic chip, in the microfluidic pump chip, and after the output port of the microfluidic pump chip, so as to monitor the entire liquid circuit.

6. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 1, characterized in that: The alarm modes of the alarm unit include light alarm, vibration alarm and sound alarm.

7. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 6, characterized in that: The alarm unit further includes a wireless transmission module.

8. The abnormal infusion state detection and control system based on a microfluidic pump according to claim 1, characterized in that: The control driving unit adjusts the parameters of the driving signal output to the microfluidic pump chip according to the output of the signal processing unit, and the parameters include the driving signal voltage value, the driving signal frequency and the driving signal duty cycle.

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