A blood measuring device

Abstract

The present invention relates to a blood measuring device, the blood measuring instrument comprises an electrical connection component, a processor and a display element, and the blood test strip comprises a substrate; the processor is electrically connected to the electrical connection component and the display element respectively; the processor comprises an identification element and a calculation processing element electrically connected to each other; the electrical connection component is provided with x electrical connection elements, and the identification element is provided with y identification units; and x and y are positive integers, 4≤x; the calculation processing element is electrically connected to the display element; the two ends of the substrate are respectively an electrical connector and a blood drop plate; the substrate is provided with n reaction layers, and the electrical connector comprises m electrodes; and n and m are both positive integers, 2≤m. The beneficial effects are: the degree of concentration is high, and the measurement of multiple data can be realized through one test strip port; multiple reaction layers are not connected to exactly the same electrodes, so that different data can be recorded separately, confusion is not easy to occur, and no electrical signal influence will be generated, thereby improving the reliability of measurement.

Description

Technical Field

[0001] The invention belongs to the technical field of blood detection, and in particular relates to a blood measuring device. Background Art

[0002] Existing blood testing devices have a single function and can generally only detect one value, such as cholesterol content, uric acid, etc. When measuring different indicators, it is often necessary to draw blood from the finger multiple times. However, since the human body's own blood is always in a state of circulation, drawing blood from the finger at different times will affect the final measurement result to a certain extent; even if the interval between blood drawing is short, the final result will be inaccurate.

[0003] Of course, when multiple tests are needed now, some will increase the amount of blood collected at one time; although this can improve the consistency of blood samples, the increase in blood collection will also increase the trauma of the test subject to a certain extent.

[0004] For example, blood samples A, B, C, and D are taken to measure triglycerides, cholesterol, uric acid, and blood sugar respectively; at this time, due to the order of blood sampling, the blood that produces these four values ​​will itself be different, and it is difficult to achieve consistency in the test samples.

[0005] Existing testing instruments can only be used with test strips with a single function; or they simply combine multiple testing components into one. In simple terms, multiple sets of processing components of multiple sets of equipment are installed in one housing and share one display component, which makes the equipment less intensive.

[0006] When the device needs to match multiple different test strips, set up multiple connection ports, and process multiple data, it is easy to generate electrical signal interference with each other. Summary of the invention

[0007] In order to solve the above problems, the present invention adopts the following technical solutions:

[0008] A blood measuring device, comprising a blood measuring instrument and a blood test strip detachably connected to each other; the blood measuring instrument comprises an electrical connection component, a processor and a display element, and the blood test strip comprises a substrate;

[0009] The processor is electrically connected to the electrical connection component and the display element respectively;

[0010] The processor includes an identification element and a computing processing element electrically connected to each other;

[0011] The electrical connection assembly is provided with x electrical connection elements, and the identification element is provided with y identification units; and x, y are positive integers, 4≤x; any of the identification units are electrically connected to any two electrical connection elements, and any two of the identification units are at most commonly connected to one identical electrical connection element;

[0012] The computing and processing element is electrically connected to the display element;

[0013] The two ends of the substrate are respectively an electrical connector and a blood drop plate;

[0014] The substrate is provided with n reaction layers, and the electrical connection member comprises m electrodes; and n and m are both positive integers, 2≤m;

[0015] Any of the reaction layers is electrically connected to any two electrodes, and any two of the reaction layers are at most commonly connected to one same electrode;

[0016] The blood dripping area on the blood dripping plate is connected to the reaction layer through the blood guide groove; the reaction layer is provided with an enzyme reaction membrane;

[0017] The number of the electrical connection elements is equal to that of the electrodes, and they are individually matched and connected one by one.

[0018] Preferably, the reaction layer is connected to the electrode via a wire; the wire and the blood guide groove are respectively arranged on two different surfaces of the substrate.

[0019] Preferably, the reaction layer is provided with a working electrode and a reference electrode; the working electrode and the reference electrode are connected to two different electrodes; and the enzyme reaction membrane is covered and connected to the working electrode and the reference electrode.

[0020] Preferably, the number of the reaction layers is 4, the number of the electrodes is 5; the electrical connection assembly is provided with 5 electrical connection elements, and the identification element is provided with 4 identification units.

[0021] Preferably, the five electrodes are respectively a, b, c, d, and e electrode columns, and the five electrical connection elements are respectively a, b, c, d, and e electrical connection terminals that are detachably connected to the five electrode columns; the enzyme reaction membranes in the four reaction layers are respectively triglyceride enzyme reaction membrane, cholesterol enzyme reaction membrane, uricase reaction membrane, and blood glucose enzyme reaction membrane; a triglyceride hydrolyzer, a cholesterol hydrolyzer, a uric acid hydrolyzer, and a blood glucose hydrolyzer are provided at one end of the blood guide groove close to the blood dripping area; the four recognition units are respectively a triglyceride recognition end, a cholesterol recognition end, a uric acid recognition end, and a blood glucose recognition end.

[0022] Preferably, the triglyceride enzyme reaction membrane is connected to the a and e connecting columns, the cholesterol enzyme reaction membrane is connected to the b and e connecting columns, the uricase reaction membrane is connected to the c and e connecting columns, and the blood glucose enzyme reaction membrane is connected to the d and e connecting columns; the triglyceride recognition end is connected to the a and e electrical connection terminals, the cholesterol recognition end is connected to the b and e electrical connection terminals, the uric acid recognition end is connected to the c and e electrical connection terminals, and the blood glucose recognition end is connected to the d and e electrical connection terminals.

[0023] Preferably, the computing and processing element has n computing modules, and the computing modules are matched with n identification units respectively; after any identification unit forms an electrical signal exchange with the computing and processing element, the computing module matched with the identification unit starts analysis.

[0024] Preferably, the calculation processing element is provided with a current detection element; the current detection element detects the current between two electrical connection elements connected to any one of the identification units; and the information obtained by the current detection element is transmitted to the calculation module.

[0025] Preferably, any of the identification units is provided with a current detection element; the current detection element detects the current between two electrical connection elements connected to the identification unit; the current detection element is electrically connected to the calculation and processing element to exchange information.

[0026] Preferably, the blood guide groove and the reaction layer are both in the siphon sample guide groove; isolation layers are also provided on both sides of the substrate; and an electron transfer medium is provided in the enzyme reaction membrane.

[0027] The beneficial effects of the present invention are:

[0028] 1. High degree of integration, multiple data can be measured through one test strip port;

[0029] 2. The measurement data is highly reliable and stable;

[0030] 3. It can achieve one-time blood sampling, small blood volume, and simultaneous measurement of multiple values;

[0031] 4. The blood used for multiple measurement values ​​is the same, which reduces the error;

[0032] 5. Multiple reaction layers are not connected to exactly the same electrodes, so different data can be recorded separately, which is not easy to cause confusion and will not produce electrical signal influence, thus improving the reliability of measurement. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is a schematic diagram of the structural principle of the present invention;

[0034] Figure 2 This is a schematic diagram of the structural principle of the blood measuring instrument of the present invention;

[0035] Figure 3 This is a schematic diagram of the structural principle of one side of the blood test strip of the present invention;

[0036] Figure 4 for Figure 2 Schematic diagram of the partial structure principle of the blood measuring instrument;

[0037] Figure 5 for Figure 3 Schematic diagram of the structural principle of the other side of the blood test strip;

[0038] Figure 6 for Figure 3 Cross-section diagram of blood test strips.

[0039] In the figure: 1 blood measuring instrument, 2 blood test strip, 10 substrate, 11 reaction layer, 12 blood guide groove, 20 electrical connector, 21 electrode, 22 wire, 30 blood drop plate, 31 blood drop area, 40 isolation layer, 100 electrical connection assembly, 110 electrical connection element, 200 processor, 210 identification element, 220 calculation processing element, 2100 identification unit, 300 display element. DETAILED DESCRIPTION

[0040] The present invention will be further described below in conjunction with the accompanying drawings:

[0041] like Figure 1 , 6 As shown, a blood measuring device comprises a blood measuring instrument 1 and a blood testing strip 2 which are detachably connected to each other; the blood measuring instrument 1 comprises an electrical connection component 100, a processor 200 and a display element 300, and the blood testing strip 2 comprises a substrate 10;

[0042] The processor 200 is electrically connected to the electrical connection component 100 and the display element 300 respectively;

[0043] The processor 200 includes an identification element 210 and a calculation processing element 220 electrically connected to each other;

[0044] The electrical connection assembly 100 is provided with x electrical connection elements 110, and the identification element 210 is provided with y identification units 2100; and x and y are positive integers, 4≤x; any of the identification units 2100 are electrically connected to any two electrical connection elements 110, and any two of the identification units 2100 are at most commonly connected to one identical electrical connection element 110;

[0045] The computing and processing element 220 is electrically connected to the display element 300;

[0046] The two ends of the substrate 10 are respectively an electrical connector 20 and a blood drop plate 30;

[0047] The substrate 10 is provided with n reaction layers 11, and the electrical connection member 20 includes m electrodes 21; and n and m are both positive integers, 2≤m;

[0048] Any of the reaction layers 11 is electrically connected to any two electrodes 21, and any two of the reaction layers 11 are at most commonly connected to one identical electrode 21;

[0049] The blood dripping area 31 on the blood dripping plate 30 is connected to the reaction layer 11 through the blood guide groove 12; the reaction layer 11 is provided with an enzyme reaction membrane;

[0050] The number of the electrical connection elements 110 and the number of the electrodes 21 are equal, and they are matched and connected one by one.

[0051] The reaction layer 11 is connected to the electrode 21 via a wire 22 ; the wire and the blood guide groove 12 are respectively arranged on two different sides of the substrate 10 .

[0052] The reaction layer 11 is provided with a working electrode and a reference electrode; the working electrode and the reference electrode are connected to two different electrodes 21; the enzyme reaction membrane is covered and connected to the working electrode and the reference electrode.

[0053] The number of the reaction layers 11 is 4, and the number of the electrodes 21 is 5; the electrical connection assembly 100 is provided with 5 electrical connection elements 110 , and the identification element 210 is provided with 4 identification units 2100 .

[0054] Combination Figure 4 and Figure 5 The five electrodes 21 are electrode columns a, b, c, d, and e respectively, and the five electrical connection elements 110 are electrical connection terminals a, b, c, d, and e that are detachably connected to the five electrode columns; the enzyme reaction membranes in the four reaction layers 11 are respectively triglyceride lipase reaction membranes, cholesterol enzyme reaction membranes, uricase reaction membranes, and blood glucose enzyme reaction membranes; a triglyceride hydrolyzer, a cholesterol hydrolyzer, a uric acid hydrolyzer, and a blood glucose hydrolyzer are provided at one end of the blood guide groove 12 close to the blood dripping area 31; the four recognition units 2100 are respectively a triglyceride recognition end, a cholesterol recognition end, a uric acid recognition end, and a blood glucose recognition end.

[0055] The present invention detects enzymes through the principle of direct electrochemical biosensor; the enzymes in the enzyme reaction membrane combine with triglycerides, sugars and the like in the blood and rapidly decompose them into free enzymes, thereby generating electrons.

[0056] like Figure 1 , 4, the triglyceride lipase reaction membrane is connected to the a and e connecting columns, the cholesterol enzyme reaction membrane is connected to the b and e connecting columns, the uricase reaction membrane is connected to the c and e connecting columns, and the blood glucose enzyme reaction membrane is connected to the d and e connecting columns; the triglyceride lipase reaction membrane is connected to the a and e connecting columns, the cholesterol enzyme reaction membrane is connected to the b and e connecting columns, the uricase reaction membrane is connected to c and e, and the blood glucose enzyme reaction membrane is connected to the d and e connecting columns; and all the wires are not cross-arranged.

[0057] The triglyceride recognition end is connected to the electrical connection terminals a and e, the cholesterol recognition end is connected to the electrical connection terminals b and e, the uric acid recognition end is connected to the electrical connection terminals c and e, and the blood sugar recognition end is connected to the electrical connection terminals d and e.

[0058] The reaction times of triglyceride lipase, cholesterol enzyme, uricase and glycemia enzyme after encountering blood are 60 seconds, 30 seconds, 10 seconds and 5 seconds respectively; the blood dripping area, blood guide groove 12 and reaction layer 11 are all in the siphon sample guide groove. Through the siphon sample guide groove, the time for blood to enter each reaction layer 11 from the blood dripping area 31 is very short, and the error of entering each reaction layer is about 0.1 second, which can be ignored compared with other reaction times, and can be considered to enter each reaction layer 11 at the same time.

[0059] For example, the blood measuring instrument 1 can first determine that the current signal is generated by the cholesterol reaction layer based on the current between the b and e connecting columns, and then further calculate the cholesterol index and other data through the current and other numerical values. The specific method of calculating the cholesterol index through the current is a well-known technology.

[0060] Since the time when the two reaction slots generate current has a long time interval, and since different reaction layers 11 and two different electrical connection elements 110 of the blood measuring instrument 1 form electrical connections, different connection methods can match the different reaction layers 11 individually; thus, different identification ternary elements 2100 can identify the electrical connection elements 110 to determine the corresponding reaction slots. At the same time, since different reaction layers 11 do not have overlapping current loops, they will not generate current interference with each other.

[0061] According to the above arrangement, the problem of short circuit caused by the bare wires a to e being arranged crosswise is solved. When the number of wire reaction layers 11 is greater than 4, it is also necessary to arrange the wires to ensure that the wires connecting different electrodes 21 do not cross each other. There is no need to set two terminals separately for each reaction layer 11, which reduces the volume of the test paper and the difficulty of wiring.

[0062] The computing and processing element 220 has n computing modules, which are matched with n identification units 2100 respectively; after any identification unit 2100 forms an electrical signal exchange with the computing and processing element 220, the computing module matched with the identification unit 2100 starts the analysis.

[0063] Different calculation modules have different calculation methods. For example, cholesterol and triglycerides need to be calculated according to the current through different calculation formulas.

[0064] One working method is that the computing and processing element 220 is provided with a current detection element; the current detection element detects the current between two electrical connection elements 110 connected to any one of the identification units 2100; and the information obtained by the current detection element is transmitted to the computing module.

[0065] like Figure 4 When an identification unit 2100 and two electrically connected elements 110 generate an electrical circuit, the identification unit 2100 sends a signal to the calculation processing element 220. The current detection element of the calculation processing element 220 detects the current between the two electrically connected elements 110 of the identification unit 2100, and then transmits the measured data to the calculation module. The calculation module performs calculations based on the data, feeds back the results, and transmits them to the display element 300 through the calculation processing element 220.

[0066] Alternatively, any of the identification units 2100 is provided with a current detection element, and after the current is generated, the current detection elements detect the current; the current detection element is electrically connected to the calculation processing element 220 and exchanges information; the current detection element detects the current between the two electrically connected elements 110 connected to the identification unit 2100, and the detection information between the current detection elements is transmitted to the calculation processing element 220, and further transmitted to the operation module, and after the operation module calculates, the display information is displayed to the display element 300 through the calculation processing element 220.

[0067] Among them, the specific operation method of the operation module is a well-known technology. For example, after triglyceride hydrolysis and enzyme reaction, the electrochemical action will generate current, which is relatively stable and specific to other components and enzyme reactions. The triglyceride content can be calculated based on the current.

[0068] The blood guide groove 12 and the reaction layer 11 are both in the siphon sample guide groove; isolation layers 40 are also provided on both sides of the substrate 10; and an electron transfer medium is provided in the enzyme reaction membrane.

[0069] like Figure 1 , 4 In the embodiment, a drop of blood sample is dropped on the blood dripping area 31, and then the blood quickly enters each reaction layer 11 from the blood guide groove 12, and the blood reacts with the enzyme reaction membrane in the reaction layer 11, and generates current after a certain period of time; the specific reaction principle and the principle of generating current are well-known technologies and will not be elaborated in detail;

[0070] Taking reaction layer A as an example, it is set to detect triglycerides; when blood enters reaction layer A, an electrochemical reaction occurs, and further an electric current is generated in about 60 seconds, and the current is transmitted to the a and e electrical connection terminals through the a and e connecting columns; the electrical signal is then recognized by the triglyceride recognition terminal, at which time the computing processing element 220 can determine that the data matches triglycerides, and randomly transmit the data to the matching operation module, which calls the triglyceride-related calculation method to calculate the required value based on the current value.

[0071] In addition, the present invention is not limited to the above-mentioned embodiments. As long as the technical effects of the present invention are achieved by substantially the same means, they should fall within the protection scope of the present invention.

Claims

1. A blood measuring device, comprising a blood measuring instrument (1) and a blood test strip (2) which are detachably connected to each other; the blood measuring instrument (1) comprises an electrical connection component (100), a processor (200) and a display element (300), and the blood test strip (2) comprises a substrate (10); characterized in that: The processor (200) is electrically connected to the electrical connection component (100) and the display element (300) respectively; The processor (200) includes an identification element (210) and a calculation processing element (220) electrically connected to each other; The electrical connection assembly (100) is provided with x electrical connection elements (110), and the identification element (210) is provided with y identification units (2100); and x and y are positive integers, 4≤x; any one of the identification units (2100) is electrically connected to any two electrical connection elements (110), and any two of the identification units (2100) are at most commonly connected to one identical electrical connection element (110); The computing and processing element (220) is electrically connected to the display element (300); The two ends of the substrate (10) are respectively an electrical connector (20) and a blood drop plate (30); The substrate (10) is provided with n reaction layers (11), and the electrical connection member (20) comprises m electrodes (21); and n and m are both positive integers, 2≤m; Any of the reaction layers (11) is electrically connected to any two electrodes (21), and any two of the reaction layers (11) are at most commonly connected to only one identical electrode (21); The blood dripping area (31) on the blood dripping plate (30) is connected to the reaction layer (11) through the blood guide groove (12); the reaction layer (11) is provided with an enzyme reaction membrane; The number of the electrical connection elements (110) and the number of the electrodes (21) are equal and they are connected in a one-to-one matching manner; in, The reaction layer (11) is provided with a working electrode and a reference electrode; the working electrode and the reference electrode are connected to two different electrodes (21); the enzyme reaction membrane is covered and connected to the working electrode and the reference electrode, the number of the reaction layers (11) is 4, and the number of the electrodes (21) is 5; the electrical connection assembly (100) is provided with 5 electrical connection elements (110), the identification element (210) is provided with 4 identification units (2100), the 5 electrodes (21) are respectively a, b, c, d, e electrode columns, and the 5 electrical connection elements are (110) are respectively electrical connection terminals a, b, c, d, and e that are detachably connected to the five electrode columns; the enzyme reaction membranes in the four reaction layers (11) are respectively triglyceride lipase reaction membrane, cholesterol enzyme reaction membrane, uricase reaction membrane, and blood glucose enzyme reaction membrane; the end of the blood guide groove (12) close to the blood dripping area (31) is provided with a triglyceride hydrolyzer, a cholesterol hydrolyzer, a uric acid hydrolyzer, and a blood glucose hydrolyzer; the four recognition units (2100) are respectively a triglyceride recognition end, a cholesterol recognition end, a uric acid recognition end, and a blood glucose recognition end.

2. A blood measuring device according to claim 1, characterized in that: The reaction layer (11) and the electrode (21) are connected via a wire (22); the wire and the blood guide groove (12) are respectively arranged on two different surfaces of the substrate (10).

3. A blood measuring device according to claim 1, characterized in that: The triglyceride enzyme reaction membrane is connected to the a and e connection columns, the cholesterol enzyme reaction membrane is connected to the b and e connection columns, the uricase reaction membrane is connected to the c and e connection columns, and the blood glucose enzyme reaction membrane is connected to the d and e connection columns; the triglyceride recognition end is connected to the a and e electrical connection terminals, the cholesterol recognition end is connected to the b and e electrical connection terminals, the uric acid recognition end is connected to the c and e electrical connection terminals, and the blood glucose recognition end is connected to the d and e electrical connection terminals.

4. A blood measuring device according to claim 1, characterized in that: The computing processing element (220) has n computing modules, each of which is matched with n identification units (2100); after any of the identification units (2100) forms an electrical signal exchange with the computing processing element (220), the computing module matched with the identification unit (2100) starts analysis.

5. A blood measuring device according to claim 4, characterized in that: The calculation processing element (220) is provided with a current detection element; the current detection element detects the current between two electrical connection elements (110) connected to any one of the identification units (2100); and the information obtained by the current detection element is transmitted to the calculation module.

6. A blood measuring device according to claim 4, characterized in that: Any of the identification units (2100) is provided with a current detection element; the current detection element detects the current between two electrical connection elements (110) connected to the identification unit (2100); the current detection element is electrically connected to the calculation processing element (220) and exchanges information.

7. A blood measuring device according to claim 1, characterized in that: The blood guide groove (12) and the reaction layer (11) are both in the siphon sample guide groove; isolation layers (40) are also provided on both sides of the substrate (10); and an electron transfer medium is provided in the enzyme reaction membrane.

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