Perfusion and drainage system for the bone marrow cavity

Abstract

The perfusion and drainage system for the bone marrow cavity relates to the technical field of medical equipment, and includes a groove section, a circular tube section and a bifurcated section; the groove section is provided with a drainage groove, a perfusion lumen, a heating lumen and a sensor for monitoring physical and / or chemical changes in the bone marrow cavity, and the drainage groove, the perfusion lumen and the heating lumen are extended along the length direction of the groove section; the bifurcated section is provided with a perfusion channel, a heating channel and a drainage channel that do not interfere with each other, the perfusion channel is connected to the perfusion lumen of the groove section, the heating channel is connected to the heating lumen of the groove section, the perfusion channel, the heating channel and the drainage channel are divided into multiple channels after being led out of the bifurcated section, the input end of the drainage channel is connected to the drainage groove of the groove section, and the output end of the drainage channel is connected to the circular tube section. The perfusion and drainage system has a good bone marrow cavity drainage effect, can realize the perfusion of medication in the bone marrow cavity, and can also monitor the physical and / or chemical changes in the bone marrow cavity, and has broad prospects for clinical application.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, and in particular to a perfusion and drainage system for a bone marrow cavity. Background Art

[0002] The drainage tube is a common disposable negative pressure drainage device. The commonly used drainage tube structure is shown in Figure 1 and Figure 2 As shown, it mainly includes a groove segment 1 (the groove segment 1 can be Figure 1 and Figure 2 The cross four-channel structure shown in the figure can also be a three-channel or other multi-channel structure) and a round tube segment 2. When in use, the groove segment 1 is buried in the subcutaneous wound or surgical incision of the human body. By connecting the rear end of the round tube segment 2 to a negative pressure source, the pus, exuded blood, tissue fluid, etc. accumulated in the wound or incision of the human body can be guided out of the body by the negative pressure suction effect, so as to prevent liquid congestion from causing postoperative infection and affecting wound healing.

[0003] The bone marrow cavity is a hollow cavity in the human body, which contains a large amount of adipose tissue, hematopoietic stem cells, bone marrow stromal stem cells and immune cells. Due to the poor fluidity of fat, the existing drainage tubes are less effective when used for bone marrow cavity drainage.

[0004] Certain chemotherapy drugs used in tumor treatment are restricted in clinical use because of their strong stimulation to the walls of peripheral blood vessels. However, the bone marrow cavity exchanges blood with peripheral blood through blood sinusoids. Since the bone tissue in the bone marrow cavity is more physically and chemically stable than the vascular matrix of peripheral blood vessels, the above drugs that have strong stimulation to the walls of blood vessels can actually be used in the bone marrow cavity. If a system that can be used for drug infusion and drainage in the bone marrow cavity can be designed, it will have very positive clinical significance. For example, for local infection of bone tissue or bone tissue tumors, the perfusion and drainage system can make chemotherapy drugs obtain higher drug concentrations locally in a shorter time, thereby improving the treatment effect, and the drainage effect of the system can timely drain the remaining drugs after taking effect to the outside of the body, avoiding excessive drug entry into systemic tissues and increasing the metabolic burden of liver and kidney functions. Summary of the invention

[0005] The purpose of the present invention is to provide a perfusion and drainage system for a bone marrow cavity, which has a good bone marrow cavity drainage effect and can be used to perfuse medication in the bone marrow cavity. Furthermore, the perfusion and drainage system can also monitor physical and / or chemical changes in the bone marrow cavity.

[0006] In order to achieve the above-mentioned object, the present invention adopts the following technical scheme: a perfusion and drainage system for a bone marrow cavity, characterized in that it comprises a groove section, a circular tube section and a bifurcation section;

[0007] The groove section is provided with a drainage groove, a perfusion lumen and a heating lumen, and the drainage groove, the perfusion lumen and the heating lumen are extended along the length direction of the groove section;

[0008] The bifurcated section is provided with a perfusion channel, a heating channel and a drainage channel which do not interfere with each other. The perfusion channel is connected to the perfusion tube cavity of the groove section, and the heating channel is connected to the heating tube cavity of the groove section. The perfusion channel, the heating channel and the drainage channel are divided into multiple paths after being led out of the bifurcated section. The drainage channel is a single path. The input end of the drainage channel is connected to the drainage groove of the groove section, and the output end of the drainage channel is connected to the circular tube section.

[0009] Wherein, a sensor for monitoring physical and / or chemical changes in the bone marrow cavity is arranged in the groove section.

[0010] Furthermore, the sensor is used to monitor one or more of the temperature, pH, pressure, tumor markers, small molecule RNA, stem cell aging molecular markers, hematopoietic stem cell markers, B cells, and T cells in the bone marrow cavity.

[0011] Preferably, a plurality of cable ties are arranged at intervals in the drainage groove along its length direction. The cable ties are made of a stretchable elastic material and tie up the sensor by its own elastic force, thereby fixing the sensor in the drainage groove.

[0012] In one embodiment of the present invention, the front end of the heating tube cavity is closed, and a heating wire is arranged in the heating tube cavity. The lead wire of the external power supply of the heating wire extends outward from the heating channel of the bifurcated section.

[0013] In one embodiment of the present invention, the heating tube cavity of the groove section includes an inlet pipe and a return pipe, and the heating channel of the bifurcated section includes an inlet channel and an outlet channel, the inlet channel is connected to the front end of the inlet pipe, the end of the inlet pipe is connected to the front end of the return pipe, and the end of the return pipe is connected to the outlet channel.

[0014] Preferably, the end of the water inlet pipeline is connected to the front end of the water return pipeline via a hollow U-shaped elbow, and the U-shaped elbow is detachably connected to the end of the water inlet pipeline and the front end of the water return pipeline.

[0015] Furthermore, plug connectors are provided at both ends of the U-shaped elbow, and the plug connectors at both ends of the U-shaped elbow are respectively inserted into the water inlet pipe and the water return pipe.

[0016] In the above embodiment, preferably, the branching section includes a branching joint which is overall "Y"-shaped, and the branching joint includes an input end and two output ends, the heating channel and the perfusion channel extend through the input end to one of the output ends and lead out, and the drainage channel extends through the input end to the other output end and leads out.

[0017] In addition, a balloon is provided between the groove segment and the fork of the bifurcation segment. Inflating the balloon or injecting liquid into the balloon to make it expand and enlarge can prevent the groove segment from escaping from the bone marrow cavity. After the gas or liquid in the balloon is extracted to make it shrink and become smaller, the groove segment can be extracted from the bone marrow cavity.

[0018] Preferably, the inner wall of the drainage groove and / or the perfusion lumen and / or the heating lumen is also coated with a functional coating, and the functional coating is one or more of a developing coating, a pharmaceutically active agent coating, a sustained-release drug coating, a conductive coating, and a magnetic conductive coating.

[0019] Among them, the input end of the bifurcated joint is connected to the groove section, the circular pipe section is connected to the output end corresponding to the drainage channel, and the output ends corresponding to the heating channel and the perfusion channel are connected to a branch pipe, and the branch pipe is provided with a heating pipe connected to the heating channel and a perfusion pipe connected to the perfusion channel.

[0020] Furthermore, an adapter is connected to the end of the branch pipe, and a heating port and a perfusion port are provided on the adapter. The heating port is connected to the heating pipe, and the perfusion port is connected to the perfusion pipe. The diameter of the perfusion port is larger than the diameter of the guide wire, and the guide wire can be inserted from the front end of the perfusion lumen of the groove section and then pass through the perfusion port.

[0021] Compared with the existing drainage tube, the perfusion and drainage system for the bone marrow cavity provided by the present invention can not only quickly drain the liquid accumulated in the bone marrow cavity to the outside of the body, but also realize the function of using medicine in the bone marrow cavity. Specifically, 1. During drainage, the end of the circular tube segment is connected to a negative pressure source. Since a heating pipeline is provided in the perfusion and drainage system of the present invention, the accumulated liquid can be heated by the heating pipeline to improve its fluidity, thereby better ensuring the drainage effect. 2. Since a perfusion pipeline is provided in the perfusion and drainage system of the present invention, when using medicine in the bone marrow cavity, the medicine can be perfused into the bone marrow cavity through the perfusion pipeline, and when the medicine takes effect, the remaining medicine can be drained to the outside of the body in time through the drainage pipeline, so as to avoid excessive entry of the medicine into the whole body tissue and increase the metabolic burden of liver and kidney function. By providing a sensor in the groove segment, the perfusion and drainage system of the present invention can also monitor the physical and / or chemical changes in the bone marrow cavity, and medical personnel can determine a more appropriate treatment plan based on the monitoring results. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of a cross four-channel drainage tube in the prior art;

[0023] Figure 2 for Figure 1 Schematic diagram of the cross-sectional structure of the middle groove section;

[0024] Figure 3 for Figure 1 A partial enlarged view of the middle A area;

[0025] Figure 4 This is a schematic diagram of the overall structure of the perfusion and drainage system for the bone marrow cavity involved in Example 1;

[0026] Figure 5 for Figure 4 A partial enlarged view of the middle A area;

[0027] Figure 6 for Figure 4 A partial enlarged view of the B area;

[0028] Figure 7 for Figure 4 Schematic diagram of the cross-sectional structure of the middle groove section;

[0029] Figure 8 It is a schematic diagram of the overall structure of the U-shaped elbow;

[0030] Fig. 9 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity involved in Example 2, in which the sensor and the cable tie are not shown;

[0031] Fig.10 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 3, in which the sensor and the cable tie are not shown;

[0032] Fig.11 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 4, in which the sensor and the cable tie are not shown;

[0033] Fig.12 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 5, in which the sensor and the cable tie are not shown;

[0034] Fig.13 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 6, in which the sensor and the cable tie are not shown;

[0035] Fig.14This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 7, in which the sensor and the cable tie are not shown;

[0036] Fig.15 This is a schematic diagram of the cross-sectional structure of the groove section in the perfusion and drainage system for the bone marrow cavity according to Example 8, in which the sensor and the cable tie are not shown;

[0037] In the figure:

[0038] 1——Groove section 2——Circular pipe section

[0039] 3——Bifurcation section 4——Heating wire

[0040] 5——U-shaped elbow 6——Ball body

[0041] 7——Branch pipe 8——Adapter

[0042] 9 - Sensor 1a - Drainage groove

[0043] 1b - perfusion lumen 1c - heating lumen

[0044] 1d——Bracket 1e——Cable tie

[0045] 3a - Fork connector 5a - Plug connector

[0046] 8a - Heating port 8b - Infusion port

[0047] 1c1——water inlet pipe 1c2——water return pipe

[0048] 1d1——rib 3a1——input terminal

[0049] 3a2——Output terminal. DETAILED DESCRIPTION

[0050] In the description of the present invention, it should be understood that the terms "front", "rear", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as limiting the present invention. The term "plurality" means more than two (including two).

[0051] To facilitate those skilled in the art to understand the improvements of the present invention over the prior art, the present invention is further described below in conjunction with embodiments and drawings.

[0052] Example 1

[0053] like Figure 4-7As shown, the perfusion and drainage system for the bone marrow cavity involved in this embodiment includes a groove section 1, a circular tube section 2 and a bifurcated section 3. Among them, the groove section 1 is provided with a drainage groove 1a, a perfusion lumen 1b and a heating lumen 1c, and the perfusion lumen 1b is arranged at the center of the bracket 1d of the groove section 1. The above-mentioned drainage groove 1a, perfusion lumen 1b and heating lumen 1c are extended along the length direction of the groove section 1, and the bracket 1d includes a plurality of radially arranged ribs 1d1. It should be noted that the extension along the length direction of the groove section 1 mentioned here can be a straight extension along the length direction, or a spiral extension forward along the length direction. In addition, a perfusion channel, a heating channel and a drainage channel (the perfusion channel, the heating channel and the drainage channel are not shown in the drawings) that do not interfere with each other are provided in the bifurcation section 3. The perfusion channel is connected to the perfusion lumen 1b of the groove section 1, and the heating channel is connected to the heating lumen of the groove section 1. The perfusion channel, the heating channel and the drainage channel are divided into multiple paths after being led out through the bifurcation section 3. The drainage channel is a separate path. The input end of the drainage channel is connected to the drainage groove 1a of the groove section 1, and the output end of the drainage channel is connected to the circular tube section 2.

[0054] The above-mentioned perfusion and drainage system for the bone marrow cavity has the function of quickly draining the liquid accumulated in the bone marrow cavity to the outside of the body, and can also realize the function of using medicine in the bone marrow cavity. During drainage, the end of the circular tube segment 2 is connected to a negative pressure source. Since a heating pipeline is provided in the perfusion and drainage system, the accumulated liquid can be heated by the heating pipeline to improve its fluidity, thereby better ensuring the drainage effect. Since a perfusion pipeline is provided in the perfusion and drainage system, when using medicine in the bone marrow cavity, the medicine can be perfused into the bone marrow cavity through the perfusion pipeline, and when the medicine takes effect, the remaining medicine can be drained to the outside of the body in time through the drainage pipeline, so as to avoid excessive entry of the medicine into the whole body tissue and increase the metabolic burden of the liver and kidney functions.

[0055] Further, see Figure 7As shown, a sensor 9 for monitoring physical and / or chemical changes in the bone marrow cavity is also provided in the groove segment 1. The sensor 9 includes, but is not limited to, monitoring one or more of the temperature, pH, pressure, tumor markers, small molecule RNA, stem cell aging molecular markers, hematopoietic stem cell markers, B cells, and T cells in the bone marrow cavity. By arranging the sensor 9 in the groove segment 1, the perfusion and drainage system can also monitor the physical and / or chemical changes in the bone marrow cavity, and medical personnel can determine a more appropriate treatment plan based on the monitoring results. It should be noted that the sensor 9 can be set at different positions in the groove segment 1. For example, the sensor 9 can be installed and fixed by opening a hole in the rib 1d1 of the bracket 1d. However, if the sensor 9 is installed by opening a hole in the rib 1d1, the length of the groove segment 1 cannot be trimmed, and the factory needs to produce perfusion and drainage systems of various specifications with different lengths of the groove segment 1 to meet the use requirements under different conditions. As a preferred way to install the sensor 9, Figure 7 As shown, a plurality of cable ties 1e can be arranged at intervals along the length direction of the drainage groove 1a. The cable ties 1e are made of a stretchable elastic material and rely on their own elastic force to tie up the sensor 9, thereby fixing the sensor 9 in the drainage groove 1a. The advantage of such a design is that medical personnel can trim the length of the groove segment 1 as needed during clinical use. First, the length of the groove segment 1 is cut to a suitable size, and then a cable tie 1e with a suitable position is selected in the remaining groove segment 1 to fix the sensor 9. It should be noted that in this embodiment, the sensor 9 can be a wireless sensor or a traditional wired sensor, and the wire of the wired sensor can also be set in the drainage groove 1a. The wire can be separated from the drainage channel in the bifurcation section 3 and then led out to an external monitoring device.

[0056] In addition, see Figure 4As shown, the aforementioned bifurcated section 3 includes a bifurcated joint 3a which is in a "Y" shape as a whole. The bifurcated joint 3a includes an input end 3a1 and two output ends 3a2. The heating channel and the perfusion channel extend through the input end 3a1 to one of the output ends 3a2 and are led out. The drainage channel extends through the input end 3a1 to the other output end 3a2 and is led out. The input end 3a1 of the bifurcated joint 3a is connected to the groove section 1, the circular tube section 2 is connected to the output end 3a2 corresponding to the drainage channel, and the output ends 3a2 corresponding to the heating channel and the perfusion channel are connected to a branch pipe 7, and a heating pipe connected to the heating channel and a perfusion pipe connected to the perfusion channel are arranged in the branch pipe 7. An adapter 8 is connected to the end of the branch pipe 7. The adapter 8 is provided with a heating port 8a and an irrigation port 8b. The heating port 8a is connected to the heating pipeline, and the irrigation port 8b is connected to the irrigation pipeline. The diameter of the irrigation port 8b is larger than the diameter of the guide wire, so that the guide wire can be inserted from the front end of the irrigation lumen 1b of the groove segment 1 and then pass through the irrigation port 8b. When inserting the cannula, the groove segment 1 of the irrigation and drainage system can be accurately inserted into the designated position in the bone marrow cavity under the guidance of the smooth guide wire. In addition, if Figure 4 As shown, a capsule 6 may be provided between the groove segment 1 and the fork of the bifurcated segment 3. By inflating the capsule 6 or injecting liquid to expand it, the groove segment 1 may be prevented from escaping from the medullary cavity. By extracting the gas or liquid in the capsule 6 to shrink it and reduce it, the groove segment 1 may be extracted from the medullary cavity.

[0057] See Figure 5 and Figure 7As shown, in this embodiment, the heating tube cavity 1c of the groove section 1 includes an inlet pipe 1c1 and a return pipe 1c2 (the inlet pipe 1c1 and the return pipe 1c2 in the figure have two each), and correspondingly, the heating channel of the bifurcated section 3 includes an inlet channel and an outlet channel (the inlet channel and the outlet channel are not shown in the figure), the inlet channel is connected to the front end of the inlet pipe 1c1, the end of the inlet pipe 1c1 is connected to the front end of the return pipe 1c2, and the end of the return pipe 1c2 is connected to the outlet channel. During drainage, hot water can be injected into the inlet pipe 1c1, and the hot water returns through the return pipe 1c2 to form a circulation loop. The circulating hot water can be used to heat the liquid accumulated in the bone marrow cavity and improve its fluidity. It should be pointed out that if the end of the water inlet pipe 1c1 is directly connected to the front end of the water return pipe 1c2 as a whole, the length of the groove section 1 cannot be trimmed, and the factory needs to produce a variety of specifications of perfusion and drainage systems with different lengths of the groove section 1 to meet the use requirements under different conditions. As a preferred structure, in actual application, the end of the water inlet pipe 1c1 can be connected to the front end of the water return pipe 1c2 through a hollow U-shaped elbow 5, and the U-shaped elbow 5 is detachably connected to the end of the water inlet pipe 1c1 and the front end of the water return pipe 1c2. For example, plug connectors 5a can be provided at both ends of the aforementioned U-shaped elbow 5, and the plug connectors 5a at both ends of the U-shaped elbow 5 can be inserted into the water inlet pipe 1c1 and the water return pipe 1c2 respectively, so that the U-shaped elbow 5 can be detachably connected to the water inlet pipe 1c1 and the water return pipe 1c2. The advantage of this design is that medical personnel can trim the length of the groove section 1 as needed during clinical use. First, the length of the groove section 1 is cut to a suitable size, and then the U-shaped elbow 5 is connected to the end of the water inlet pipe 1c1 and the front end of the water return pipe 1c2.

[0058] Example 2

[0059] The main difference between this embodiment and embodiment 1 is that the heating method is different. Fig. 9 As shown, in this embodiment, the heating lumen 1c is arranged at the center of the bracket 1d of the groove section 1 and its front end is closed (the structure of the front end of the heating lumen 1c being closed is not shown in the figure), and the perfusion lumen 1b is arranged in a rib 1d1 of the bracket 1d, and a heating wire 4 is arranged in the heating lumen 1c, and the lead wire of the external power supply of the heating wire 4 extends outward from the heating channel of the bifurcation section 3. It should be pointed out that the key difference between this embodiment and Example 1 is that the heating is achieved by arranging the heating wire 4 in the heating lumen 1c. Although the positions of the heating lumen 1c and the perfusion lumen 1b in this embodiment are also different from those in Example 1, this is not the key point. In order to simplify the description, other structures similar to Example 1 in this embodiment are not described here.

[0060] Example 3

[0061] The difference between this embodiment and embodiment 1 mainly lies in the structural form of the heating pipeline and the location of the perfusion lumen 1b. Fig.10 As shown, in this embodiment, the perfusion lumen 1b is arranged in a rib 1d1 of the bracket 1d, and an arc-shaped sheet is arranged in the gap between the two groups of ribs 1d1. The two ends of the arc-shaped sheet are respectively connected to the side walls of the ribs 1d1 located on both sides thereof. The cavity surrounded by the arc-shaped sheet and the ribs 1d1 constitutes the water inlet pipeline 1c1 and the water return pipeline 1c2 of the heating lumen 1c. Fig.10 The number of the water inlet pipeline 1c1 and the water return pipeline 1c2 are both one.

[0062] Example 4

[0063] The main difference between this embodiment and embodiment 3 is that the position of the perfusion lumen 1b is different. Fig.11 As shown, in this embodiment, the perfusion lumen 1b is disposed at the center of the stent 1d.

[0064] Example 5

[0065] The difference between this embodiment and embodiment 1 mainly lies in the structural form and the location of the heating pipeline and the location of the perfusion lumen 1b. Fig.12 As shown, in this embodiment, a cylindrical central axis is arranged at the center of the bracket 1d, the perfusion tube cavity 1b is arranged at the center of the central axis, and there are two water inlet pipes 1c1 and two water return pipes 1c2, and both are arranged in the central axis. Different from Embodiments 1-4, the cross-sectional shape of the water inlet pipe 1c1 and the water return pipe 1c2 in this embodiment is circular.

[0066] Example 6

[0067] The difference between this embodiment and embodiment 5 is mainly the number of heating pipelines and the shape of the central axis. Fig.13 As shown, in this embodiment, the number of the water inlet pipe 1c1 and the water return pipe 1c2 are both one. Since one water inlet pipe 1c1 and one water return pipe 1c2 are omitted, the central axis can be made into a semi-cylindrical shape.

[0068] Example 7

[0069] The main difference between this embodiment and embodiment 4 is that the shape of the heating pipeline is different. Fig.14As shown, in this embodiment, the heating tube cavity 1c includes a water inlet pipe 1c1 and a water return pipe 1c2. The water inlet pipe 1c1 and the water return pipe 1c2 are both round tubes arranged in the gap between a group of ribs 1d1. The round tube is fixedly connected to the side walls of the ribs 1d1 on both sides thereof (for example, it can be fixedly connected by ultrasonic welding or bonding). Like Example 4, the perfusion tube cavity 1b in this embodiment is also arranged at the center of the bracket 1d.

[0070] Example 8

[0071] The main difference between this embodiment and embodiment 7 is that the position of the perfusion lumen 1b is different. Fig.15 As shown, in this embodiment, the perfusion lumen 1b is not arranged at the center of the stent 1d, but is arranged in a rib 1d1.

[0072] It should be pointed out that, in addition to the structural forms and positions shown in Examples 1-8, those skilled in the art should understand that in the perfusion and drainage system involved in the present invention, the heating pipeline and the perfusion lumen 1b can also adopt other structural forms, and they can also be arranged in other different positions as needed. To simplify the description, they are not listed one by one here.

[0073] Finally, in the above embodiments 1-8, a functional coating may be applied to the inner wall of the drainage groove 1a and / or the perfusion lumen 1b and / or the heating lumen 1c as required, and the functional coating may be one or more of a developing coating, a drug active agent coating, a sustained-release drug coating, a conductive coating, and a magnetic coating. For example, a developing coating may be applied to the inner wall of the heating lumen 1c, a drug active agent coating (the drug active agent may be, for example, a luminescent agent, an antibody antigen reaction reagent, a color developing agent, etc.) may be applied to the inner wall of the drainage groove 1a, and a sustained-release drug coating (the sustained-release drug may be, for example, an antibiotic, hormone, growth factor, analgesic, etc. with sustained-release efficacy) may be applied to the inner wall of the perfusion lumen 1b, etc. Of course, a conductive coating or a magnetic coating may also be applied to the inner wall of the drainage groove 1a, so that the bone marrow cavity may be stimulated by electric current or stimulated by introducing electric current to cause temperature changes, or stimulated by magnetic field. It should be noted that the materials used in the above functional coatings are all existing materials in the prior art. Those skilled in the art should be aware that the present invention does not involve improvements to the material components used in the above functional coatings.

[0074] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention may also be implemented in other ways. Any obvious replacement without departing from the concept of the present technical solution is within the protection scope of the present invention.

[0075] In order to make it easier for ordinary technicians in the field to understand the improvements of the present invention over the prior art, some drawings and descriptions of the present invention have been simplified, and for the sake of clarity, some other elements are omitted in this application document. Ordinary technicians in the field should realize that these omitted elements may also constitute the content of the present invention.

Claims

1. A perfusion and drainage system for a bone marrow cavity, characterized in that: It comprises a groove section (1), a circular pipe section (2) and a bifurcated section (3); The groove section (1) is provided with a drainage groove (1a), a perfusion lumen (1b) and a heating lumen (1c), wherein the drainage groove (1a), the perfusion lumen (1b) and the heating lumen (1c) are extended along the length direction of the groove section (1); The bifurcated section (3) is provided with a perfusion channel, a heating channel and a drainage channel which do not interfere with each other; the perfusion channel is connected to the perfusion lumen (1b) of the groove section (1); the heating channel is connected to the heating lumen of the groove section (1) to form a heating pipeline for heating the stagnant liquid in the bone marrow cavity to improve its fluidity; the perfusion channel, the heating channel and the drainage channel are divided into multiple channels after being led out of the bifurcated section (3); the drainage channel is a single channel; the input end of the drainage channel is connected to the drainage groove (1a) of the groove section (1); and the output end of the drainage channel is connected to the circular tube section (2); A sensor (9) for monitoring physical and / or chemical changes in the bone marrow cavity is provided in the groove section (1); A functional coating is coated on the inner wall of the drainage groove (1a) and / or the perfusion lumen (1b) and / or the heating lumen (1c), and the functional coating is one or more of a developing coating, a pharmaceutically active agent coating, a sustained-release drug coating, a conductive coating, and a magnetic conductive coating.

2. The perfusion and drainage system for the bone marrow cavity according to claim 1, characterized in that: The sensor (9) is used to measure the temperature in the bone marrow cavity, pH, pressure, One or more of tumor markers, small molecule RNA, stem cell aging molecular markers, hematopoietic stem cell markers, B cells, and T cells are monitored.

3. The perfusion and drainage system for the bone marrow cavity according to claim 1, characterized in that: A plurality of tie ties (1e) are arranged at intervals in the drainage groove (1a) along its length direction; the tie ties (1e) are made of a stretchable elastic material and use their own elastic force to tie up the sensor (9), thereby fixing the sensor (9) in the drainage groove (1a).

4. The perfusion and drainage system for the bone marrow cavity according to any one of claims 1 to 3, characterized in that: The heating tube cavity (1c) of the groove section (1) comprises a water inlet pipeline (1c1) and a water return pipeline (1c2), and the heating channel of the bifurcated section (3) comprises a water inlet channel and a water outlet channel, the water inlet channel is connected to the front end of the water inlet pipeline (1c1), the end of the water inlet pipeline (1c1) is connected to the front end of the water return pipeline (1c2), and the end of the water return pipeline (1c2) is connected to the water outlet channel.

5. The perfusion and drainage system for the bone marrow cavity according to any one of claims 1 to 3, characterized in that: The front end of the heating tube cavity (1c) is closed, and a heating wire (4) is arranged in the heating tube cavity (1c). The lead wire of the heating wire (4) connected to an external power source extends outward from the heating channel of the branch section (3).

6. The perfusion and drainage system for the bone marrow cavity according to claim 4, characterized in that: The end of the water inlet pipeline (1c1) is connected to the front end of the water return pipeline (1c2) via a hollow U-shaped elbow (5); the U-shaped elbow (5) is detachably connected to the end of the water inlet pipeline (1c1) and the front end of the water return pipeline (1c2); plug connectors (5a) are provided at both ends of the U-shaped elbow (5); the plug connectors (5a) at both ends of the U-shaped elbow (5) are respectively inserted into the water inlet pipeline (1c1) and the water return pipeline (1c2).

7. The perfusion and drainage system for the bone marrow cavity according to any one of claims 1 to 3, characterized in that: The bifurcated section (3) comprises a bifurcated joint (3a) which is in a "Y" shape as a whole. The bifurcated joint (3a) comprises an input end (3a1) and two output ends (3a2). The heating channel and the perfusion channel extend through the input end (3a1) to one of the output ends (3a2) and are led out. The drainage channel extends through the input end (3a1) to the other output end (3a2) and is led out.

8. The perfusion and drainage system for the bone marrow cavity according to claim 7, characterized in that: The input end (3a1) of the bifurcated joint (3a) is connected to the groove section (1), the circular tube section (2) is connected to the output end (3a2) corresponding to the drainage channel, and the output ends (3a2) corresponding to the heating channel and the perfusion channel are connected to a branch pipe (7), wherein a heating pipe connected to the heating channel and a perfusion pipe connected to the perfusion channel are provided in the branch pipe (7).

9. The perfusion and drainage system for the bone marrow cavity according to claim 8, characterized in that: The end of the branch pipe (7) is connected to an adapter (8), and the adapter (8) is provided with a heating port (8a) and a perfusion port (8b). The heating port (8a) is connected to the heating pipeline, and the perfusion port (8b) is connected to the perfusion pipeline. The diameter of the perfusion port (8b) is larger than the diameter of the guide wire, and the guide wire can be inserted from the front end of the perfusion lumen (1b) of the groove section (1) and then pass through the perfusion port (8b).

10. The perfusion and drainage system for the bone marrow cavity according to any one of claims 1 to 3, characterized in that: A sac (6) is provided between the groove section (1) and the fork of the bifurcated section (3). The sac (6) is inflated with air or injected with liquid to expand it so as to prevent the groove section (1) from falling out of the bone marrow cavity. The groove section (1) can be withdrawn from the bone marrow cavity after the gas or liquid in the sac (6) is extracted so as to shrink it.

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