A method and system for integrating repetitive transcranial magnetic stimulation and electrical stimulation

Abstract

The present invention discloses a method and system for integrating repetitive transcranial magnetic stimulation and electrical stimulation. According to the treatment mode, a stimulation signal generator in a navigation mode is selected to send a stimulation signal for the treatment mode, and the stimulation signal is sent to a signal control module; the signal control module converts and conditions the stimulation signal in step S1, and sends the processed stimulation signal to a repetitive transcranial magnetic stimulation device and an electrical stimulation device respectively; the repetitive transcranial magnetic stimulation device and the electrical stimulation device simultaneously receive the stimulation signal processed by the signal control module, and synchronously complete the magnetic stimulation and electrical stimulation of the human brain; after the repetitive transcranial magnetic stimulation device stimulates the human brain, it simultaneously sends a feedback signal to the electrical stimulation device to record the number of stimulations. The doctor's treatment stimulation plan for the patient can be loaded into the navigation signal generator, and a synchronous stimulation signal is uniformly sent to the magnetic stimulation device and the electrical stimulation device to complete the electromagnetic integrated stimulation of the patient.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a method and system for integrating repetitive transcranial magnetic stimulation and electrical stimulation. Background Art

[0002] As non-invasive neuromodulation technologies, repetitive transcranial magnetic stimulation (rTMS or TMS) and transcranial direct current stimulation (tDCS) have gradually gained wide recognition in the fields of neurology, psychiatry, rehabilitation, etc., and have become effective, non-invasive research and diagnosis tools in the field of neuroscience. In recent years, the use of TMS and tDCS to treat consciousness disorders has been one of the hot topics in this field. Existing research results have confirmed that rTMS and tDCS technologies have certain therapeutic effects on patients with brain function diseases, which can improve the level of consciousness and neurobehavioral function.

[0003] Transcranial magnetic stimulation technology achieves the purpose of stimulating biological tissues or neurons by applying a high-intensity changing electromagnetic field to the organism. It is mainly based on the Biot-Savart law, and a changing magnetic field is generated by a changing current, that is, a changing pulse current is applied to the coil of the transcranial magnetic stimulator to generate a changing magnetic field. The strength of the magnetic field and the stimulation time of biological tissues are controlled by changing the pulse frequency and current size of the pulse current. After the induced changing magnetic field acts on human tissues, a weak current will be generated in the human tissues. These weak currents will cause neuronal cells to be excited or inhibited when they reach a certain intensity.

[0004] Transcranial direct current stimulation (tDCS) attaches two electrodes (usually a cathode and an anode) to different areas of the skull, delivering a constant, low-intensity direct current to specific areas within the skull, thereby increasing or decreasing the excitability of neurons in the cerebral cortex, thereby causing functional changes in the brain. It can be used in clinical treatment research for diseases such as Alzheimer's disease, Parkinson's disease, and cognitive impairment.

[0005] The mechanisms of action of rTMS and tDCS are different. rTMS uses a pulsed magnetic field to non-intentionally act on the cerebral cortex, inducing induced currents in the target area of ​​the cerebral cortex (called the stimulation target), affecting the metabolism and excitability of the cerebral cortex, regulating brain function, and achieving the effect of treatment. tDCS uses continuous, constant, and weak currents to act on cortical brain tissue, affecting the resting membrane potential of neurons, causing changes in neuronal excitability, and achieving the purpose of regulating and treating brain function. In terms of the range of action areas, TMS has good focus and can achieve localized stimulation of the cerebral cortex; tDCS can induce excitement or inhibition of brain function over a large range. Previous studies have used rTMS alone or tDCS alone to treat brain function diseases, and their combined use has not been seen. Summary of the invention

[0006] In response to the above-mentioned technical problems in the related art, the present invention proposes a method and system for integrating repetitive transcranial magnetic stimulation and electrical stimulation, which can load the doctor's treatment stimulation plan for the patient into the navigation signal generator, and uniformly send synchronous stimulation signals to the magnetic stimulation device and the electrical stimulation device to complete the integrated electromagnetic stimulation of the patient.

[0007] To achieve the above technical objectives, the technical solution of the present invention is implemented as follows: a method for integrating repetitive transcranial magnetic stimulation and electrical stimulation, comprising the following steps:

[0008] S1: selecting a stimulation signal generator in the navigation mode according to the treatment mode, issuing a stimulation signal for the treatment mode, and sending the stimulation signal to the signal control module;

[0009] S2: The signal control module converts and conditions the stimulation signal in step S1, and sends the processed stimulation signal to the repetitive transcranial magnetic stimulation device and the electrical stimulation device respectively;

[0010] S3: the repetitive transcranial magnetic stimulation device receives the stimulation signal processed by the signal control module, the electrical stimulation device receives the stimulation signal processed by the signal control module, and synchronously completes the magnetic stimulation and electrical stimulation of the human brain;

[0011] S4: After the repetitive transcranial magnetic stimulation device stimulates the human brain, it simultaneously sends a feedback signal to the electrical stimulation device to record the number of stimulations.

[0012] Furthermore, the signal control module in step S2 performs multi-channel enabling processing on the stimulation signal generated by the stimulator and level conversion of the stimulation signal.

[0013] Furthermore, the electrical stimulation device is provided with counting software for receiving the feedback signal.

[0014] Furthermore, the repetitive transcranial magnetic stimulation device is a multi-target synchronous repetitive transcranial magnetic stimulation device.

[0015] According to another aspect of the present invention, a system integrating repetitive transcranial magnetic stimulation and electrical stimulation is provided, the system comprising a stimulation signal generator, a signal control module, a repetitive transcranial magnetic stimulation device and an electrical stimulation device, wherein:

[0016] A stimulation signal generator, used to generate stimulation signals according to a treatment plan input by the control software;

[0017] A signal control module, used for receiving and processing the stimulation signal sent by the stimulation signal generator;

[0018] a repetitive transcranial magnetic stimulation device, used for receiving the stimulation signal from the signal control module and converting the stimulation signal into a magnetic signal;

[0019] The electrical stimulation device is used to receive the stimulation signal from the signal control module and the return signal from the repetitive transcranial magnetic stimulation device, and convert the stimulation signal into an electrical signal.

[0020] Furthermore, the stimulation signal generator is a stimulation signal generator in a navigation mode.

[0021] Furthermore, the signal control module performs multi-channel enabling processing on the stimulation signal and level conversion on the stimulation signal.

[0022] Furthermore, the repetitive transcranial magnetic stimulation device is a multi-target synchronous repetitive transcranial magnetic stimulation device, and the repetitive transcranial magnetic stimulation device generates magnetic stimulation by discharging a coil.

[0023] Furthermore, the electrical stimulation device generates electrical stimulation by discharging the coil, and a counting system is installed in the electrical stimulation device.

[0024] Furthermore, the magnetic signal and the electrical signal complete the stimulation synchronously.

[0025] Beneficial effects of the present invention: The system implements tDCS and rTMS simultaneously, with direct current stimulation continuously targeting certain areas to increase or decrease excitability, while superimposing the pulsed magnetic field of rTMS to regulate excitability, further amplifying the regulatory effect, so as to achieve the purpose of strengthening or weakening the functional connection of the brain network, thereby promoting the regulation of brain functional diseases, solving the problem of electromagnetic integrated stimulation, and combining the respective advantages of electromagnetic stimulation to give full play to the advantages of electromagnetic integrated treatment of brain functional diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 It is a structural diagram of a repetitive transcranial magnetic stimulation and electrical stimulation integrated system according to an embodiment of the present invention. DETAILED DESCRIPTION

[0028] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the present invention.

[0029] like Figure 1 As shown, a method for integrating repetitive transcranial magnetic stimulation and electrical stimulation according to an embodiment of the present invention comprises the following steps:

[0030] S1: selecting a stimulation signal generator in the navigation mode according to the treatment mode, issuing a stimulation signal for the treatment mode, and sending the stimulation signal to the signal control module;

[0031] S2: The signal control module converts and conditions the stimulation signal in step S1, and sends the processed stimulation signal to the repetitive transcranial magnetic stimulation device and the electrical stimulation device respectively;

[0032] S3: the repetitive transcranial magnetic stimulation device receives the stimulation signal processed by the signal control module, the electrical stimulation device receives the stimulation signal processed by the signal control module, and synchronously completes the magnetic stimulation and electrical stimulation of the human brain;

[0033] S4: After the repetitive transcranial magnetic stimulation device stimulates the human brain, it simultaneously sends a feedback signal to the electrical stimulation device to record the number of stimulations.

[0034] In a specific embodiment of the present invention, the signal control module in step S2 performs multi-channel enabling processing and level conversion of the stimulation signal generated by the stimulator.

[0035] In a specific embodiment of the present invention, the electrical stimulation device is provided with counting software for receiving the feedback signal.

[0036] In a specific embodiment of the present invention, the repetitive transcranial magnetic stimulation device is a multi-target synchronous repetitive transcranial magnetic stimulation device.

[0037] According to another aspect of the present invention, a system integrating repetitive transcranial magnetic stimulation and electrical stimulation is provided, the system comprising a stimulation signal generator, a signal control module, a repetitive transcranial magnetic stimulation device and an electrical stimulation device, wherein:

[0038] A stimulation signal generator, used to generate stimulation signals according to a treatment plan input by the control software;

[0039] A signal control module, used for receiving and processing the stimulation signal sent by the stimulation signal generator;

[0040] a repetitive transcranial magnetic stimulation device, used for receiving the stimulation signal from the signal control module and converting the stimulation signal into a magnetic signal;

[0041] The electrical stimulation device is used to receive the stimulation signal from the signal control module and the return signal from the repetitive transcranial magnetic stimulation device, and convert the stimulation signal into an electrical signal.

[0042] In a specific embodiment of the present invention, the stimulation signal generator is a stimulation signal generator in a navigation mode.

[0043] In a specific embodiment of the present invention, the signal control module performs multi-channel enabling processing on the stimulation signal and level conversion of the stimulation signal.

[0044] In a specific embodiment of the present invention, the repetitive transcranial magnetic stimulation device is a multi-target synchronous repetitive transcranial magnetic stimulation device, and the repetitive transcranial magnetic stimulation device generates magnetic stimulation by discharging a coil.

[0045] In a specific embodiment of the present invention, the electrical stimulation device generates electrical stimulation by discharging a coil, and a counting system is installed in the electrical stimulation device.

[0046] In a specific embodiment of the present invention, the magnetic signal and the electrical signal are synchronized to complete the stimulation.

[0047] In order to facilitate understanding of the above technical solutions of the present invention, the above technical solutions of the present invention are described in detail below through specific usage methods.

[0048] During specific use, when the system according to the present invention works, the navigation mode stimulation signal generator first sends out different stimulation control signals according to different treatment modes, and then converts and conditions the stimulation signals through the signal module, and then sends them to the repetitive transcranial magnetic stimulation device and the electrical stimulation device. The repetitive transcranial magnetic stimulation device and the electrical stimulation device complete synchronous stimulation. While completing the magnetic stimulation, the repetitive transcranial magnetic stimulation device transmits the stimulation signal back to the counting system in the electrical stimulation device to record the information of the stimulation signal.

[0049] In summary, by means of the above technical solution of the present invention, by combining TMS and tDCS, it is found that the sequential application of the two does change the changes in cortical excitability caused by the single application of one of them. The system implements tDCS and rTMS simultaneously, direct current stimulation continuously targets certain areas to increase or decrease excitability, and at the same time superimposes the pulsed magnetic field of rTMS to regulate excitability, further amplifying the regulatory effect, so as to achieve the purpose of strengthening or weakening the functional connection of the brain network, thereby promoting the regulation of brain functional diseases.

[0050] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A system integrating repetitive transcranial magnetic stimulation and electrical stimulation, characterized in that: The system includes a stimulation signal generator, which is a stimulation signal generator in navigation mode, used to generate a stimulation signal according to a treatment plan input by the control software, and send the stimulation signal to a signal control module; A signal control module, used to receive and process the stimulation signal sent by the stimulation signal generator, and send the processed stimulation signal to the repetitive transcranial magnetic stimulation device and the electrical stimulation device respectively, to complete the synchronous stimulation of the magnetic signal and the electrical signal; the signal control module performs multi-channel enabling processing and level conversion on the stimulation signal; A repetitive transcranial magnetic stimulation device, configured to receive the first stimulation signal sent by the signal control module and convert the first stimulation signal into a magnetic signal; the repetitive transcranial magnetic stimulation device is a multi-target synchronous repetitive transcranial magnetic stimulation device, and the repetitive transcranial magnetic stimulation device generates magnetic stimulation by discharging a coil; An electrical stimulation device is used for converting the first stimulation signal emitted by the signal control module and the feedback signal emitted by the repetitive transcranial magnetic stimulation device into an electrical signal; the electrical stimulation device generates electrical stimulation by discharging the coil, and a counting system is installed in the electrical stimulation device.

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