Length-controllable liquid crystal segmented copolymer micelle and preparation method thereof

Abstract

The invention provides a two-block polymer nano-micelle, a two-block polymer in the micelle is poly (2-vinylpyridine-b-poly2-(-perfluorooctyl) ethyl methacrylate (namely P2VP-b-PFMA), and the micelleis prepared by dispersing a block copolymer P2VP-b-PFMA, phenyl selenium bromide and 4-dimethylaminopyridine in isopropanol, heating, cooling and preparing. After 4-dimethylaminopyridine is added as acocatalyst in the preparation of the diblock polymer nano-micelle, the size of the formed micelle can be accurately controlled, the particle size distribution of the micelle is more centralized, theexperiment period is short, the steps are simple, the repeatability is good, the production cost is lower, and the industrial production is facilitated.

Description

technical field

[0001] The invention relates to the technical field of surface-modified functional micro-nano structures, in particular to a length-controllable liquid crystal block copolymer micelle and a preparation method thereof. Background technique

[0002] The precise synthesis of multi-level fine structures ubiquitous in biological systems has captured the imagination of materials scientists striving to mimic the complexity, homogeneity, and versatility of naturally occurring systems. In recent years, the prior art has discovered some methods to prepare nanomaterials with fine structure, for example, solid-state aggregation of giant amphiphilic molecules to form ordered morphology; controlled crystallization of nanoparticles to generate superlattice, crystal block copolymerization The epitaxial growth of objects to produce exotic nanostructures; the directional assembly of sheet-like colloidal nanoparticles to construct multidimensional hierarchical structures; the f...

Examples

Embodiment 1

[0026] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 68 -b-PFMA 41 1.00mg, 0.09mg of phenylselenium bromide and 0.009mg of 4-dimethylaminopyridine were dispersed in 10ml of isopropanol to form a solution, and then the solution was heated to 80°C and kept at constant temperature for 30min, then cooled down to room temperature, that is Obtain; After measuring, the polymer nanomicelle average length is a columnar micelle of 337nm, and the dispersion coefficient is 1.000 (such as figure 1 shown in a).

Embodiment 2

[0028] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 400 -b-PFMA 42 Disperse 1.0mg, 0.005mg of phenylselenium bromide and 0.0006mg of 4-dimethylaminopyridine into 10ml of methanol to form a solution, then heat the solution to 80°C for 30min at a constant temperature, and then cool down to room temperature to obtain the product; After measuring, described polymer nanomicelle average length is the columnar micelle of 1600nm, dispersion coefficient is 1.003 (as figure 2 shown in a).

Embodiment 3

[0030] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 262 -b-PFMA 53 0.5mg, 0.0004mg of phenylselenium bromide and 0.0001mg of 4-dimethylaminopyridine were dispersed in 10ml of isopropanol to form a solution, and then the solution was heated to 80°C and kept at constant temperature for 30min, then cooled down to room temperature, that is Obtain; After measuring, the polymer nanomicelle average length is the columnar micelle of 4576nm, and dispersion coefficient is 1.006 (as image 3 shown in a).

technical field

[0001] The invention relates to the technical field of surface-modified functional micro-nano structures, in particular to a length-controllable liquid crystal block copolymer micelle and a preparation method thereof. Background technique

[0002] The precise synthesis of multi-level fine structures ubiquitous in biological systems has captured the imagination of materials scientists striving to mimic the complexity, homogeneity, and versatility of naturally occurring systems. In recent years, the prior art has discovered some methods to prepare nanomaterials with fine structure, for example, solid-state aggregation of giant amphiphilic molecules to form ordered morphology; controlled crystallization of nanoparticles to generate superlattice, crystal block copolymerization The epitaxial growth of objects to produce exotic nanostructures; the directional assembly of sheet-like colloidal nanoparticles to construct multidimensional hierarchical structures; the f...

Examples

Embodiment 1

[0026] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 68 -b-PFMA 41 1.00mg, 0.09mg of phenylselenium bromide and 0.009mg of 4-dimethylaminopyridine were dispersed in 10ml of isopropanol to form a solution, and then the solution was heated to 80°C and kept at constant temperature for 30min, then cooled down to room temperature, that is Obtain; After measuring, the polymer nanomicelle average length is a columnar micelle of 337nm, and the dispersion coefficient is 1.000 (such as figure 1 shown in a).

Embodiment 2

[0028] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 400 -b-PFMA 42 Disperse 1.0mg, 0.005mg of phenylselenium bromide and 0.0006mg of 4-dimethylaminopyridine into 10ml of methanol to form a solution, then heat the solution to 80°C for 30min at a constant temperature, and then cool down to room temperature to obtain the product; After measuring, described polymer nanomicelle average length is the columnar micelle of 1600nm, dispersion coefficient is 1.003 (as figure 2 shown in a).

Embodiment 3

[0030] A preparation method of diblock polymer nano micelles, comprising: weighing block copolymer P2VP according to the above ratio 262 -b-PFMA 53 0.5mg, 0.0004mg of phenylselenium bromide and 0.0001mg of 4-dimethylaminopyridine were dispersed in 10ml of isopropanol to form a solution, and then the solution was heated to 80°C and kept at constant temperature for 30min, then cooled down to room temperature, that is Obtain; After measuring, the polymer nanomicelle average length is the columnar micelle of 4576nm, and dispersion coefficient is 1.006 (as image 3 shown in a).

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