A special animal gavage device for Chinese medicine pills
By designing a special animal gavage apparatus for Chinese medicine pills, the problem of crushing Chinese medicine pills into liquid in experiments was solved, safe and efficient solid drug delivery was achieved, and experimental efficiency and accuracy were improved.
Patent Information
- Application Number
- CN202011640576.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2020-12-31
- Publication Date
- 2025-09-30
- Estimated Expiration
- 2040-12-31
AI Technical Summary
In existing animal experiments on traditional Chinese medicine pills, the oral gavage method requires the pills to be crushed into liquid, which destroys their solid properties. Direct administration is also inconvenient and can easily harm animals, resulting in low experimental efficiency and inaccurate data.
A special animal gavage device for Chinese medicine pills is designed, which includes a gavage head, a connecting tube and a syringe device. It is made of hard transparent material, has a scale, and is combined with a lubricant for safe and painless drug administration.
The work efficiency of the gastric administration of traditional Chinese medicine pills is improved, the damage to the animal's esophagus is reduced, the accuracy of the experiment is ensured, and the digestion and absorption process of the patient taking pills in solid form is restored.
Smart Images
Figure CN112641533B_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of animal experiments, in particular to a special animal gastric gag device for traditional Chinese medicine pills. Background Art
[0002] Traditional Chinese Medicine (TCM) is an integral part of global medicine and a crucial tool for safeguarding the health of the Chinese nation and the world. Pills are one of the four classic TCM dosage forms for disease prevention and treatment, and remain a mainstream form today. The 2015 edition of the Chinese Pharmacopoeia lists 379 pill varieties, accounting for 25.18% of the total. Liuwei Dihuang Wan, a popular pill from the Song Dynasty's "Xiao'er Yaozheng Zhijue," has recently accounted for over 45% of total sales of tonifying TCM in my country, with retail sales reaching 2.057 billion yuan in 2015 alone. Beijing Tong Ren Tang (Group) Co., Ltd., a renowned TCM brand, boasts six of its top ten products, including Niuhuang Qingxin Wan, Angong Niuhuang Wan, Dahuo Luo Wan, Wuji Baifeng Wan, Jufang Zhibao Wan, and Zaizao Wan, all derived from classical Chinese medicines.
[0003] Drug experimental research is a fundamental component of all pharmaceutical work. Any drug experimental research aimed at benefiting human health must undergo animal testing. Animal testing is also an indispensable approach for the basic research and clinical development of traditional Chinese medicine pills. Currently, the most common method for experimental research on traditional Chinese medicine pills is to administer drugs via gavage to mice and rats. However, current gavage techniques utilize a mouse gavage device (typically a commercially available, custom-made 16-gauge gavage needle). This method is limited in that the gavage needle, connected to a syringe barrel, can only be used for gavage of liquid medications. Therefore, the pills must be crushed to prepare a liquid for gavage, which destroys the solid-state nature of traditional Chinese medicine pills and eliminates the need for patients to take the pills in solid form and then digest and absorb them. Furthermore, if direct administration of the drug is desired, forceps or fingers are often used to deliver the drug to the base of the animal's tongue. This is extremely inconvenient, has low efficiency, poor stability, and can easily cause damage to the mice and rats, resulting in poor experimental results and inaccurate experimental data. Summary of the Invention
[0004] The present invention aims to provide a special animal gavage device for Chinese medicine pills, which improves the working efficiency of animal gavage of Chinese medicine pills, reduces damage to the animal's esophagus, and restores the process of patients taking pills in solid form and then digesting and absorbing them into the body.
[0005] To achieve the above object, the present invention is implemented by adopting the following technical solutions:
[0006] A gastric gavage device for animals specifically for administering Chinese medicine pills, comprising a gavage head, a connecting tube, and a syringe device. The connecting tube is made of a hard material. The gavage head is in the shape of a hemispherical shell and has a through hole at its top. The inner cavity of the gavage head communicates with the inner cavity of the connecting tube through the through hole, and the gavage head is fixedly connected to one end of the connecting tube. The syringe device comprises a push rod and a syringe. The other end of the connecting tube is sleeved with the injection tip of the syringe, and the inner cavities of the connecting tube and the syringe are connected.
[0007] It also includes a gavage pusher head, which is located inside the gavage head shell and is fixedly connected to one end of the push rod located inside the injection tube through a connecting rod. The connecting rod passes through the through hole and the inner cavity of the connecting tube in sequence.
[0008] Preferably, the connecting pipe is made of hard transparent material.
[0009] Furthermore, there is a scale along the surface of the connecting pipe body.
[0010] Preferably, the surface of the injection tube is provided with injection tube scales along the tube body.
[0011] Preferably, the gavage head is made of acrylic resin.
[0012] Preferably, the syringe device is transparent throughout.
[0013] Preferably, the outer diameter of the gavage head ranges from 7.5 mm to 0.9 mm, and the inner diameter ranges from 5.5 mm to 6.5 mm.
[0014] Furthermore, the inner diameter of the connecting tube ranges from 2.5 mm to 3.5 mm, and the length ranges from 50 mm to 60 mm.
[0015] Preferably, the gavage pusher head is in the shape of an arc-shaped sheet.
[0016] The present invention has the following beneficial effects:
[0017] The technical solution involved in the present invention can be used together with a safe lubricant with no toxic side effects, causes little damage to the esophagus of mice and rats, can greatly promote the working efficiency of the gastric gavage operation of Chinese medicine pills in animals, can restore the process of patients taking pills in solid form and then digesting and absorbing them into the body, improves experimental accuracy, is easy to use, has a simple structure and low production cost. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] Figure 1 It is a schematic diagram of the structure of the present invention;
[0019] Figure 2 This is a three-dimensional diagram of the gavage head;
[0020] Figure 3 for Figure 1A partial enlarged view of part A.
[0021] In the figure: 1-gavage head, 2-connecting tube, 3-push rod, 4-injection tube, 5-injection tube scale, 6-scale, 7-traditional Chinese medicine pill, 8-through hole, 9-gavage push head, 10-connecting rod. DETAILED DESCRIPTION
[0022] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings.
[0023] like Figure 1 and 2 As shown, a special animal gavage device for Chinese medicine pills includes a gavage head, a connecting tube and a syringe device, and the syringe device is transparent throughout.
[0024] The gavage head 1 is in the shape of a hemispherical shell and has a through hole 8 at its top. The inner cavity of the gavage head 1 is connected with the inner cavity of the connecting tube 2 through the through hole 8, and the gavage head 1 is fixedly connected to one end of the connecting tube 2. The syringe device includes a push rod 3 and an injection tube 4. The other end of the connecting tube 2 is sleeved with the injection end of the injection tube 4, and the inner cavity of the connecting tube 2 is connected with the inner cavity of the injection tube 4.
[0025] In order to be able to push the Chinese medicine pills in time during use, the present invention also includes a gavage pusher head 9, which is located on the inner side of the gavage head 1 shell. The gavage pusher head 9 is fixedly connected to one end of the push rod 3 located in the injection tube 4 through a connecting rod 10. The connecting rod 10 passes through the through hole 8 and the inner cavity of the connecting tube 2 in sequence.
[0026] In order to facilitate controlling the insertion depth of the connecting tube 2 during gavage, the connecting tube 2 is made of a hard transparent material, and a scale 6 is provided along the surface of the connecting tube 2 .
[0027] In order to accurately control the amount of physiological saline or other mixed liquid, the surface of the injection tube 4 is provided with an injection tube scale 5 along the tube body.
[0028] In order to reduce the damage to the esophagus of mice and rats and to facilitate use, the gavage head 1 is made of acrylic resin.
[0029] Specifically, the outer diameter of the gavage head 1 is in the range of 7.5 mm to 0.9 mm, and the inner diameter thereof is in the range of 5.5 mm to 6.5 mm. The inner diameter of the connecting tube 2 is in the range of 2.5 mm to 3.5 mm, and the length thereof is in the range of 50 mm to 60 mm.
[0030] During the specific implementation process, an appropriate amount of physiological saline is injected into the injection tube 4, and the Chinese medicine pill 7 is inserted into the gavage head 1. During gavage, the entry depth is controlled according to the scale 6 of the connecting tube 2. When the gavage head 1 reaches the stomach, the push rod 3 is gently pushed to push the physiological saline into the gavage head 1, and then the Chinese medicine pill 7 is delivered to the stomach.
[0031] Of course, the present invention may have many other embodiments. Without departing from the spirit and essence of the present invention, those skilled in the art may make various corresponding changes and modifications based on the present invention, but these corresponding changes and modifications should all fall within the scope of protection of the claims attached to the present invention.
Claims
1. A special animal gavage device for Chinese medicine pills, characterized by: The device comprises a gavage head, a connecting tube and a syringe device. The connecting tube is made of a hard material. The gavage head is in the shape of a hemispherical shell and has a through hole at its top. The inner cavity of the gavage head is connected to the inner cavity of the connecting tube through the through hole, and the gavage head is fixedly connected to one end of the connecting tube. The syringe device comprises a push rod and an injection tube. The other end of the connecting tube is sleeved with the injection tip of the injection tube, and the inner cavity of the connecting tube is connected to the inner cavity of the injection tube. It also includes a gavage pusher head, which is located inside the gavage head housing and is fixedly connected to one end of the pusher rod located inside the injection tube via a connecting rod, wherein the connecting rod passes through the through hole and the inner cavity of the connecting tube in sequence; Inject an appropriate amount of normal saline into the injection tube, insert the Chinese medicine pill into the gavage head, and control the insertion depth according to the scale of the connecting tube during gavage. When the gavage head reaches the stomach, gently push the normal saline to the gavage head, and then deliver the Chinese medicine pill to the stomach; The outer diameter of the gavage head is in the range of 7.5mm-0.9mm, and the inner diameter is in the range of 5.5mm-6.5mm; The inner diameter of the connecting tube is in the range of 2.5mm-3.5mm, and the length is in the range of 50mm-60mm; The gavage pusher head is in an arc-shaped sheet shape.
2. The animal gavage device for Chinese medicine pills according to claim 1, characterized in that: The connecting tube is made of transparent material.
3. The animal gavage device for Chinese medicine pills according to claim 2, characterized in that: Scales are provided along the surface of the connecting pipe body.
4. The animal gavage device for Chinese medicine pills according to claim 1, characterized in that: The surface of the injection tube is provided with injection tube scales along the tube body.
5. The animal gavage device for Chinese medicine pills according to claim 1, characterized in that: The gavage head is made of acrylic resin.
6. The animal gavage device for Chinese medicine pills according to claim 1, characterized in that: The syringe device is transparent throughout.