Vaginal suppository detection device

Abstract

The present invention relates to a vaginal plug detection device, comprising: an operating body; a light emitting member, arranged in the operating body and used for generating light; a probe, having a first end and a second end arranged oppositely, the first end being matched with one end of the operating body; and a light scattering member, matched with the second end; wherein the operating body has a first light transmission part at one end close to the probe, and the light generated by the light emitting member can be transmitted to the first end of the probe through the first light transmission part; the probe has a second light transmission part connected between the first end and the second end, and the light transmitted to the first end can be transmitted to the second end through the second light transmission part, and the light scattering member is used for scattering the light transmitted to the second end. Through the vaginal plug detection device, a small-volume vaginal plug inside the vagina of an experimental animal or a vaginal plug deep in the vagina can be easily detected, thereby improving the detection efficiency and detection accuracy of the vaginal plug of the experimental animal.

Description

Technical Field

[0001] The invention relates to the technical field of experimental animal pregnancy diagnosis, in particular to a vaginal plug detection device. Background Art

[0002] Laboratory animals are animals used in scientific research, teaching, production, testing and scientific experiments. They are widely used in biomedicine, pharmaceutical research and development, teaching experiments, biological testing and other fields, and play a very important role in life science research. Because the genetic similarity between mice and humans is 99%, and the breeding and raising of mice are relatively cheap, and they reproduce quickly. At present, about 9 out of every 10 experimental animals are mice. The application fields include immunology, oncology, physiology, pathology, embryology and reproduction, and the application in neuroscience is also increasing. Mice have become synonymous with experimental animals.

[0003] In reproductive research, before using mouse fertilized eggs and embryos for various experimental operations, it is necessary to determine whether the male and female mice in the same cage have successfully mated that day. Currently, the methods used to identify whether the mating of mice in the same cage is successful mainly include the mouse vaginal smear method and the mouse vaginal plug examination method.

[0004] However, when using the above method to detect whether there is a vaginal plug in the mouse vagina, there are problems of low detection efficiency and low accuracy. Summary of the invention

[0005] Based on this, it is necessary to provide a vaginal plug detection device that can improve the detection efficiency and detection accuracy in order to address the problems of low detection efficiency and low accuracy when detecting mouse vaginal plugs.

[0006] According to one aspect of the present application, a vaginal plug detection device is provided for detecting whether there is a vaginal plug in the vagina of an experimental animal, the vaginal plug detection device comprising:

[0007] Operation body;

[0008] A light emitting element, disposed in the operating body, for generating light;

[0009] A probe having a first end and a second end arranged opposite to each other, wherein the first end is coupled to one end of the operating body; and

[0010] A light diffuser, connected to the second end;

[0011] Wherein, the end of the operating body close to the probe has a first light transmission part, and the light generated by the light emitting element can be transmitted to the first end of the probe through the first light transmission part;

[0012] The probe has a second light transmission part connected between the first end and the second end. The light transmitted to the first end can be transmitted to the second end through the second light transmission part. The light diffuser is used to diffuse the light transmitted to the second end.

[0013] In one embodiment, the radial dimension of the probe is configured to gradually decrease from the first end to the second end.

[0014] In one embodiment, the diffuser is ellipsoidal.

[0015] In one embodiment, the radial dimension of the operating body is configured to gradually decrease toward the first end, and form a light focusing portion.

[0016] In one embodiment, the light emitting element is disposed in the light focusing portion.

[0017] In one embodiment, the vaginal plug detection device further includes an energy component, which is disposed in the operating body and is used to provide energy for generating light to the light-emitting component.

[0018] In one embodiment, the vaginal plug detection device further includes a control component, which is coupled to the operating body and signal-connected to the energy component.

[0019] In one embodiment, the vaginal plug detection device further includes a cleaning member, and the cleaning member is fixed to an end of the operating body away from the probe.

[0020] In one embodiment, the vaginal plug detection device further comprises a positioning member, the positioning member is detachably connected to an end of the operating body away from the probe, and the cleaning member is fixed to the operating body by means of the positioning member.

[0021] In one embodiment, a positioning opening is formed on one side of the positioning member, the positioning member has a positioning cavity communicated with the positioning opening, the cleaning member is installed in the positioning cavity and at least partially protrudes from the positioning opening.

[0022] The vaginal plug detection device inserts the probe into the vagina of the experimental animal, and disperses the light transmitted to the probe inside the vagina of the experimental animal through the light diffuser, so that the operator can easily observe the vaginal plug with a smaller volume or a vaginal plug that is embedded deeper. In this way, the detection efficiency and detection accuracy of vaginal plugs of experimental animals can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 Schematic diagram of the structure of a vaginal plug detection device in one embodiment of the present application;

[0024] Figure 2 for Figure 1 The detection flow chart of the vaginal plug detection device shown;

[0025] Figure 3 for Figure 1 The detection flow chart of a preferred embodiment of the vaginal plug detection device is shown. DETAILED DESCRIPTION

[0026] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0027] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0028] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0029] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0031] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method.

[0032] In order to facilitate understanding of the technical solution of the present invention, before detailed description, the existing experimental animal vaginal suppository detection method is first described.

[0033] After mating, female mice will produce a mating plug, also known as a vaginal plug, in their vagina. The mouse vaginal plug is formed by the coagulation reaction of the protein in the seminal plasma of male mice in the vagina of female mice. This physiological characteristic provides a direction for accurately checking whether the mating of male and female mice in the same cage is successful.

[0034] At present, the main methods for identifying whether the mating of mice in co-cages is successful are the mouse vaginal smear method and the mouse vaginal plug inspection method. The mouse vaginal smear method has a high accuracy rate, but the operation is cumbersome, and each female mouse in the co-cage needs to make a separate vaginal secretion smear, which is time-consuming and labor-intensive, and the plug inspection results are slow; the mouse vaginal plug inspection method is direct and fast, but it is difficult to detect smaller vaginal plugs or vaginal plugs that are built deeper with the naked eye. In addition, because some black and brown strains of mice have darker fur and strong light absorption, under the illumination of ordinary fluorescent lights in SPF-grade animal rooms, less light reaches the vaginal opening of female mice, which makes it more difficult to inspect mouse vaginal plugs with the naked eye and increases the possibility of missed detection and wrong detection.

[0035] Secondly, when checking the vaginal plug of mice, the mouse's tail needs to be lifted to expose the vaginal opening. However, mice have the physiological characteristic of lifting their tails to urinate, and urine will block the vaginal opening, forming small droplets and contaminating the vaginal opening, which also brings considerable trouble to the detector's plug detection work. Some female mice also have congenital defects, such as vaginal septum. Vaginal septum grows at the vaginal opening of mice, and its morphology is similar to the plug phenomenon of mice after mating, which may confuse the test results.

[0036] Based on this, the present application provides a vaginal plug detection device and detection method, which can better improve the above-mentioned problems.

[0037] The engine cooling system and vehicle of the present application will be described below with reference to the accompanying drawings.

[0038] Figure 1 Schematic diagram of the structure of a vaginal plug detection device in one embodiment of the present application; Figure 2 for Figure 1 The detection flow chart of the vaginal plug detection device shown; Figure 3 for Figure 1 For ease of description, only structures related to the present application are shown in the accompanying drawings.

[0039] Referring to the drawings, at least one embodiment of the present application provides a vaginal plug detection device 100, which is used to detect whether there is a vaginal plug in the vagina of an experimental animal, and includes an operating body 40, a light emitting member 10, a probe 20, and a light diffusing member 30. The probe 20 has a first end and a second end that are arranged opposite to each other, the operating body 40 is connected to the first end of the probe 20, the light diffusing member 30 is connected to the second end of the probe 20, and the light emitting member 10 is arranged in the operating body 40.

[0040] In some embodiments, the operating body 40 is used to provide an operator with a gripping operating space. Specifically, in some embodiments, the operating body 40 may be cylindrical, prismatic, or other shapes, and the present application does not make specific restrictions here. As a preferred embodiment, the operating body 40 may be a cylindrical rod to improve the convenience of use for the operator.

[0041] Furthermore, the operating body 40 may be a hollow cylindrical rod, so as to effectively reduce the weight of the vaginal plug detection device 100 and improve the convenience of use of the vaginal plug detection device 100 .

[0042] Furthermore, the operating body 40 may be a hollow cylindrical rod, and the surface of the rod may be provided with concave and convex parts to improve the operability of the operator. Specifically in some embodiments, the concave and convex parts may be textures processed on the surface of the operating body 40.

[0043] In some embodiments, the longitudinal length of the operating body 40 can be set to 40 mm-60 mm.

[0044] In some embodiments, the operating body 40 has a focusing portion 41, which is disposed at one end of the operating body 40 close to the probe 20. The radial dimension of the focusing portion 41 is configured to gradually decrease from the operating body 40 toward the probe 20. Specifically, the focusing portion 41 may be a conical stage.

[0045] In some embodiments, the light emitting element 10 is disposed in the operating body 40 and can be used to generate light. Specifically, in some embodiments, the light emitting element 10 is disposed in the light focusing portion 41 of the operating body 40. In this way, the light generated by the light emitting element 10 can be more concentrated to improve the lighting effect of the light emitting element 10.

[0046] Specifically in some embodiments, the light emitting element may be an LED light source, which has good lighting effect and low energy consumption. It is understandable that the light emitting element may also be other light sources, and the present application does not make any specific limitation here.

[0047] Furthermore, the vaginal plug detection device 100 also includes an energy component, which is disposed in the operating body 40 and connected to the light-emitting component 10, and is used to provide energy to the light-emitting component 10. Specifically, in some embodiments, the light-emitting component 10 converts electrical energy into light energy, and the energy component can be configured as a battery accordingly. It should be understood that the energy component can also provide energy to the light-emitting component 10 in other energy forms.

[0048] In some embodiments, the vaginal plug detection device 100 further includes a control component, and the control component signal is connected to the energy component to control whether the light-emitting component 10 emits light.

[0049] Furthermore, the control unit can also control the energy intensity provided by the energy unit to the light emitting unit 10. In this way, it is convenient for the operator to adjust the light intensity of the light emitting unit 10 according to the experimental environment.

[0050] Furthermore, the control element is connected to the operating body 40 , so that the control convenience of the light emitting element 10 by the operator can be improved.

[0051] In some embodiments, the operating body 40 has a first light transmission portion at one end close to the probe 20 , and the light generated by the light emitting element 10 can be transmitted to the first end of the probe 20 through the first light transmission portion.

[0052] Specifically in some embodiments, the first light transmission part can be a blind hole opened at one end of the operating body 40 close to the probe 20, with the opening facing the probe 20 and connected to the first end of the probe 20. Further, the shape of the blind hole can be circular, prismatic, or triangular, and the present application does not make specific limitations here. As a preferred embodiment, the shape of the light-emitting hole is selected to be circular, so that the light emitted by the light-emitting element 10 can be gathered to improve the lighting effect.

[0053] In some embodiments, the first end of the probe 20 is detachably connected to the operating body 40. In this way, when the probe 20 is damaged, the probe 20 can be easily disassembled and replaced.

[0054] Specifically, in some embodiments, the first end of the probe 20 is provided with an external thread, and the inner wall of the operating body 40 is provided with an internal thread that can be connected with the probe 20. In this way, the tightness of the connection between the probe 20 and the operating body 40 can be improved. In other embodiments, the first end of the probe 20 is also provided with an internal thread, and the outer wall of the operating body 40 is provided with an external thread that can be connected with the probe 20. In this way, the tightness of the connection between the probe 20 and the operating body 40 can also be improved. In some other embodiments, the probe 20 can also be connected to the operating body 40 by a snap-on method.

[0055] In some embodiments, the probe 20 has a second light-transmitting portion connected between the first end and the second end, and the light transmitted to the first end can be transmitted to the second end through the second light-transmitting portion. In some embodiments, the probe 20 can be made of a transparent material, such as a transparent silicone material. In this way, light can be transmitted from the first end of the probe 20 to the second end.

[0056] In some embodiments, the radial dimension of the probe 20 is configured to gradually decrease from the first end to the second end. In this way, on the one hand, the light emitted by the light-emitting element 10 can be further concentrated, the light utilization rate is improved, the lighting effect is enhanced, and the detection efficiency and accuracy of the vaginal plug are improved; on the other hand, it is convenient for the probe 20 to be inserted into the vagina of the experimental animal, thereby improving the detection efficiency of the vaginal plug.

[0057] Specifically in some embodiments, the axial dimension of the probe 20 may be 20 mm-40 mm.

[0058] In some embodiments, the light diffuser 30 is disposed at the second end of the probe 20, and the light transmitted to the second end can be diffused inside the vagina of the experimental animal through the light diffuser 30, thereby improving the visual brightness, so that a small-volume vaginal plug inside the vagina or a vaginal plug deep in the vagina will not be missed. In this way, the detection efficiency and accuracy of vaginal plugs inside the vagina of the experimental animal are improved.

[0059] Specifically in some embodiments, the diffuser 30 can be ellipsoidal, spherical, or in other shapes. After repeated practice and experiment, the inventor found that the diffuser 30 with an ellipsoidal shape has a better light divergence effect. Therefore, as a preferred embodiment, the diffuser 30 is ellipsoidal.

[0060] In some embodiments, the vaginal plug detection device 100 further includes a cleaning member 60 , and the cleaning member 60 is fixed to an end of the operating body 40 away from the probe 20 , and is used to clean the vaginal opening of the experimental animal.

[0061] In practical application, if there are contaminants at the vaginal opening of the experimental animal, such as urine, etc., it will affect the detection accuracy of the vaginal plug. The cleaning member 60 can be used to wipe the vaginal opening of the experimental animal to clean the contaminants, and then the probe 20 can be inserted into the vagina of the experimental animal. In this way, the influence of the contaminants at the vaginal opening of the experimental animal on the detection accuracy of the vaginal plug can be eliminated.

[0062] In some embodiments, the cleaning member 60 includes at least one of cotton yarn and sponge. More specifically, the cleaning member 60 can be absorbent cotton, gauze, or other similar water-absorbing materials.

[0063] In some embodiments, the vaginal plug detection device 100 further includes a positioning member 70 , which is connected to an end of the operating body 40 away from the probe 20 , and the cleaning member 60 is fixed to the light emitting member 10 via the positioning member 70 .

[0064] Furthermore, the positioning member 70 is detachably connected to the end of the operating body 40 away from the probe 20. Specifically in practical use, the cleaning member 60 contaminated by the plug inspection work of the day can be replaced by removing the positioning member 70 after the inspection work is completed, so as to prepare for the inspection of the next batch of experimental animals.

[0065] Specifically in some embodiments, the positioning member 70 is provided with an external thread, and the inner wall of the operating body 40 is provided with an internal thread that can be connected with the positioning member 70. In this way, the tightness of the connection between the positioning member 70 and the operating body 40 can be improved. In other embodiments, the positioning member 70 is also provided with an internal thread, and the outer wall of the operating body 40 is provided with an external thread that can be connected with the positioning member 70. In this way, the tightness of the connection between the probe 20 and the operating body 40 can also be improved. In some other embodiments, the positioning member 70 can also be connected to the operating body 40 by a snap-on method.

[0066] In some embodiments, the positioning member 70 has a positioning cavity 71, and the opening structure of the positioning cavity 71 on the positioning member 70 forms a positioning opening 711. The cleaning member 60 is installed in the positioning cavity 71, and at least partially protrudes from the positioning opening 711. In this way, the stabilization effect of the cleaning member 60 is improved, and the cleaning effect of the cleaning member 60 is not affected.

[0067] In some embodiments, the positioning opening 711 is disposed at an end of the positioning member 70 away from the operating body 40. In this way, the cleaning convenience when using the vaginal plug detection device 100 is improved.

[0068] Furthermore, there may be only one positioning opening 711 or there may be multiple positioning openings 711 , which is not specifically limited in the present application.

[0069] An embodiment of the present application further provides a detection method of the vaginal plug detection device 100, comprising the following steps:

[0070] Step S310: start the light emitting element 10.

[0071] Step S320: inserting the probe 20 into the vagina of the experimental animal.

[0072] Step S330: Observe whether there is a vaginal plug in the vagina of the experimental animal.

[0073] In some embodiments, after the step of observing whether there is a vaginal plug in the vagina of the experimental animal, the method further comprises the step of:

[0074] Step S340: Produce or slide the probe 20 in the vagina of the experimental animal to identify the vaginal plug.

[0075] Specifically, when testing for vaginal septum in experimental animals with vaginal septum due to congenital defects, the vaginal septum may be mistaken for vaginal plug. To avoid this and improve the detection accuracy of vaginal plug, the probe 20 may be slightly moved or slid after entering the vaginal opening of the mouse. If fleshy tissue is observed at the vaginal opening of the mouse and the probe 20 feels meaty, it is vaginal septum; if the probe 20 feels hard and waxy, it is vaginal plug.

[0076] The vaginal plug detection device 100 can clearly observe vaginal plugs with smaller volumes and vaginal plugs located deep in the vagina through the divergent light of the light-scattering member 30 located at the second end of the probe 20; can clean pollutants at the vaginal opening through the cleaning member 60, and can eliminate the influence of pollutants on the plug detection result; can identify and distinguish the vaginal septum and vaginal plug through the touch of the probe 20 inside the vagina. In this way, the detection efficiency and detection accuracy of vaginal plugs in experimental animals are improved.

[0077] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0078] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A vaginal plug detection device, It is characterized in that include: Operation body; A light emitting element, disposed in the operating body, for generating light; The probe has a first end and a second end that are arranged opposite to each other, wherein the first end is matched with one end of the operating body; as well as A light diffuser, connected to the second end; Wherein, the end of the operating body close to the probe has a first light transmission part, and the light generated by the light emitting element can be transmitted to the first end of the probe through the first light transmission part; The probe has a second light transmission part connected between the first end and the second end. The light transmitted to the first end can be transmitted to the second end through the second light transmission part. The light diffuser is used to diffuse the light transmitted to the second end.

2. The vaginal plug detection device according to claim 1, It is characterized in that The radial dimension of the probe is configured to gradually decrease from the first end to the second end.

3. The vaginal plug detection device according to claim 1, It is characterized in that The light diffuser is in an ellipsoidal shape.

4. The vaginal plug detection device according to claim 1, It is characterized in that The operating body has a light focusing portion, which is arranged at one end of the operating body close to the probe; the radial dimension of the light focusing portion is configured to gradually decrease from the operating body toward the probe.

5. The vaginal plug detection device according to claim 4, It is characterized in that The light emitting element is arranged in the light focusing portion.

6. The vaginal plug detection device according to claim 1, It is characterized in that The vaginal plug detection device also includes an energy component, which is arranged in the operating body and is used to provide energy for generating light to the light-emitting component.

7. The vaginal plug detection device according to claim 6, It is characterized in that The vaginal plug detection device also includes a control component, which is matched with the operating body and is signal-connected to the energy component.

8. The vaginal plug detection device according to claim 1, It is characterized in that The vaginal plug detection device further comprises a cleaning member, which is fixed to an end of the operating body away from the probe.

9. The vaginal plug detection device according to claim 8, It is characterized in that The vaginal plug detection device further comprises a positioning member, which is detachably connected to an end of the operating body away from the probe, and the cleaning member is fixed to the operating body by means of the positioning member.

10. The vaginal plug detection device according to claim 9, It is characterized in that A positioning opening is formed on one side of the positioning member, and the positioning member has a positioning cavity communicated with the positioning opening. The cleaning member is installed in the positioning cavity and at least partially protrudes from the positioning opening.

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