Analysis device

Abstract

The present invention relates to an analysis device, comprising: a sample supply device for supplying samples to an empty reactor; a transfer device for carrying the reactor; a reagent supply device for supplying reagents to the reactor in the transfer device; a reaction device for reacting the reactor containing the reagents and the samples; and a transfer device for transferring the reactor between the transfer device and the reaction device; wherein the transfer device is independently arranged outside the reaction device, and the transfer device and the reaction device have no spatial overlap.

Description

Technical Field

[0001] The present invention relates to the technical field of analytical testing, and particularly to an analytical device. Background Art

[0002] The chemiluminescence immunoassay system utilizes the principles of chemiluminescence and immunoreaction to correlate the light signal with the concentration of the analyte, and analyze the content of the analyte in the sample. Due to its high sensitivity, specificity, wide linear range and other characteristics, it is being increasingly widely used. With the increase in the number of test specimens, clinical laboratories have higher and higher requirements for the volume and test throughput of the chemiluminescence immunoassay system. The chemiluminescence immunoassay system needs to realize functions such as sample transportation, reagent storage, aspiration and discharge of analytical liquids such as samples and reagents, reactor transfer, cleaning and separation, etc., and has extremely high requirements for automatic control.

[0003] The current analytical devices have complex structures, large volumes and high production costs. Summary of the Invention

[0004] Based on this, it is necessary to provide an analytical device for the above technical problems.

[0005] An analytical device includes:

[0006] A sample supply device for supplying a sample to a reactor;

[0007] A transfer device for carrying and transferring a reactor that needs to discharge a reagent;

[0008] A reagent supply device for supplying a reagent to the reactor in the transfer device;

[0009] A reaction device for reacting a reactor containing a reagent and a sample; and

[0010] A transfer device for transferring the reactor between the transfer device and the reaction device; wherein, the transfer device is independently arranged outside the reaction device, and the rotation center of the transfer device is arranged outside the reaction device.

[0011] In one embodiment, the reaction device includes a rotatable reaction disk, the transfer device includes a rotatable middle disk, and the reaction disk and the middle disk rotate independently.

[0012] In one embodiment, the diameter of the middle disk is smaller than the diameter of the reaction disk.

[0013] In one embodiment, in the top view direction, the sample supply device, the reagent supply device and the reaction device are arranged in a clockwise direction along the outer periphery of the transfer device.

[0014] In one embodiment, a cleaning and separation position, an incubation position, and a measurement position are provided on the reaction disc, and the reactor can be carried at the cleaning and separation position, the incubation position, and the measurement position.

[0015] In one embodiment, a number of reaction positions arranged in a ring are provided on the reaction disc. The innermost ring is the cleaning and separation position, the outermost ring is the measurement position, and the incubation position is between the cleaning and separation position and the measurement position. At least one ring of incubation positions is provided.

[0016] In one embodiment, the cleaning and separation position, the incubation position, and the measurement position are arranged along the radius direction of the reaction disc.

[0017] In one embodiment, the transfer trajectory of the transfer device at least covers the cleaning and separation position, the incubation position, and the measurement position.

[0018] In one embodiment, the transfer trajectory of the transfer device extends along a radius of the reaction disc and at least covers all the reaction positions along the radius on the reaction disc.

[0019] In one embodiment, at least two groups of reagent supply devices are provided, and the two groups of reagent supply devices alternately discharge reagents to the reactor on the transfer device.

[0020] In one embodiment, the reagent supply device includes a reagent disc and a reagent discharging unit. The reagent disc is used to carry reagents, and the reagent discharging unit is used to suck the reagents in the reagent disc and discharge the reagents to the reactor.

[0021] In one embodiment, the diameter of the middle turntable is smaller than the diameter of the reagent disc.

[0022] In one embodiment, a supply disc is further included. A temporary storage tank for loading the reactor is provided on the supply disc. The supply disc can rotate independently to drive the temporary storage tank to transfer at different stations, and the sample supply device is used to discharge samples to the reactor on the supply disc.

[0023] In one embodiment, the transfer trajectory of the transfer device at least covers the supply disc, the transfer device, and the reaction device.

[0024] In one embodiment, the transfer device includes a rotatable middle turntable, and the centers of the middle turntable and the supply disc are respectively located on both sides of the transfer trajectory of the transfer device.

[0025] In one embodiment, it further includes a dilution transportation device for temporarily storing the reactor, and the dilution transportation device is arranged between the reaction device and the transfer device; after the reactor receives the sample provided by the sample supply device on the supply tray, the reactor receives the diluent provided by the reagent supply device in the transfer device, and after dilution, the reactor is transferred to the dilution transportation device.

[0026] Advantageous effects: The reaction device and the transfer device are independently arranged without spatial overlap, which not only avoids problems such as complex structure, high cost, and large occupied area caused by the nested arrangement of the transfer device and the reaction device, but also solves the limitation of the structure and size of the transfer device by the reaction device, and more flexibly, efficiently, and reasonably arranges the position of the transfer device. Brief Description of the Drawings

[0027] Figure 1 Structural schematic diagram of the analysis device in an embodiment of the present application;

[0028] Figure 2 Step diagram of immunoassay in an embodiment of the present application;

[0029] Figure 3 Structural schematic diagram of the transfer device included in the analysis device in an embodiment of the present application;

[0030] Figure 4 Structural schematic diagram of the reaction site on the reaction device in an embodiment of the present application;

[0031] Figure 5 Structural schematic diagram of the transfer device in an embodiment of the present application;

[0032] Figure 6 Transfer trajectory diagram of the transfer device in an embodiment of the present application;

[0033] Figure 7 Period length diagram of the analysis device in an embodiment of the present application;

[0034] Figure 8 Structural schematic diagram of the dilution device in an embodiment of the present application;

[0035] Figure 9 Execution action diagram of the grasping unit in a certain period in an embodiment of the present application;

[0036] Figure 10 Execution action diagram of the grasping unit of the transfer device in a certain period in an embodiment of the present application;

[0037] Figure 11 For Figure 10 Execution action diagram of the shown embodiment in multiple test items.

[0038] Reference numerals: 11, first station; 12, second station; 13, third station; 14, fourth station; 15, fifth station; 16, sixth station; 100, reagent supply device; 110, reagent storage unit; 111, first reagent tray; 112, second reagent tray; 120, reagent discharging unit; 121, first reagent discharging element; 122, second reagent discharging element; 200, sample supply device; 300, reactor supply device; 310, bin structure; 320, supply chute; 400, reaction device; 410, reaction tray; 420, reaction position; 421, cleaning and separation position; 422, incubation position; 423, measurement position; 430, measurement assembly; 500, transfer device; 510, transfer drive; 520, transfer turntable; 530, temporary storage position; 600, transfer device; 611, first grasping unit; 612, second grasping unit; 621, first grasping drive; 622, second grasping drive; 630, guide rail; 631, cleaning and separation alignment position; 632, incubation alignment position; 633, measurement alignment position; 634, discarding alignment position; 635, relay alignment position; 636, transfer alignment position; 700, supply unit; 710, supply tray; 720, temporary storage tank; 800, mixing unit; 810, vibrating member; 820, vibration holes; 830, mixing drive; 900, dilution and transportation device. Detailed implementation manners

[0039] For the convenience of understanding the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Preferred embodiments of the present invention are shown in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0040] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there can also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. On the contrary, when an element is referred to as being "directly on" another element, there is no intermediate element. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0041] Figure 1FIG. 0 is a schematic structural diagram of an analysis device in an embodiment of the present application. The analysis device includes a reagent supply device 100, a sample supply device 200, a reactor supply device 300, and a reaction device 400. During operation, the sample provided by the sample supply device 200 is added to the reactor provided by the reactor supply device 300, and the reagent provided by the reagent supply device 100 is also added to the reactor provided by the reactor supply device 300. At this time, the reactor contains a mixture of the sample and the reagent. Subsequently, the mixture of the sample and the reagent is transferred to the reaction device 400 for reaction. Due to similar functions and structures, both the sample supply device 200 and the reagent supply device 100 suck and add liquid to the reactor, and the sample supply device 200 and the reagent supply device 100 can be combined into a supply device or collectively referred to as a supply device, that is, the supply device includes the sample supply device 200 and the reagent supply device 100. As Figure 1 shown, the sample supply device 200, the reagent supply device 100, and the reaction device 400 are arranged around the transfer device 500, that is, the transfer device 500 is arranged in the middle position, playing the role of transferring the reactor. By arranging the transfer device 500 in the middle position, the transfer device 500 is relatively close to other structures, which can shorten the overall transfer time of the reactor and improve work efficiency. Further, in the top view direction, the sample supply device 200, the reagent supply device 100, and the reaction device 400 are arranged counterclockwise along the outer periphery of the transfer device 500, which can enable each mechanism to work orderly, reduce interference in space, and improve work efficiency.

[0042] Specifically, the reactor supply device 300 can provide a clean and empty reactor, and the sample supply device 200 can add a sample to the empty reactor. The analysis device in an embodiment further includes a supply unit 700, and the supply unit 700 is used to receive the reactor provided by the reactor supply device 300, and the sample supply device 200 adds a sample to the empty reactor on the supply unit 700. The analysis device in an embodiment further includes a transfer device 500 and a transfer device 600, and the working path of the transfer device 600 at least covers the supply unit 700, the transfer device 500, and the reaction device 400. The transfer device 600 transfers the reactor added with the sample from the supply unit 700 to the transfer device 500, and receives the reagent provided by the reagent supply device 100 at the transfer device 500, that is, the reagent supply device 100 can add the reagent to the reactor added with the sample on the transfer device 500. At this time, the reactor contains a mixture of the sample and the reagent. The transfer device 600 is further used to transfer the reactor containing the mixture of the sample and the reagent to the reaction device 400 for reaction, and the reaction process may include one or more of incubation, cleaning, and measurement.

[0043] For example, the above analysis device can be an immunoassay device, which is a device for quantitatively or qualitatively determining target substances to be measured, such as antigens and antibodies contained in a blood sample. Taking the one-step method as an example, the overall operation of the immunoassay device will be described. Figure 2 It is a step diagram of immunoassay in an embodiment, as Figure 2 shown, the immunoassay generally completes the following steps:

[0044] S1. Provide a reactor;

[0045] S2. Add a sample and a reagent into the reactor;

[0046] S3. Mix the sample and the reagent in the reactor;

[0047] S4. Incubate the mixed sample and reagent;

[0048] S5. Wash and separate the incubated sample and reagent;

[0049] S6. Add a signal reagent into the reactor for signal incubation;

[0050] S7. Measure the luminescence amount.

[0051] Specifically, in S1, a reactor is provided by a reactor supply device 300 first.

[0052] In S2, the reagent and the sample are respectively added into the reactor through a reagent supply device 100 and a sample supply device 200. The order of adding the reagent and the sample is not limited. The reagent and the sample can be added sequentially, or the sample and the reagent can be added sequentially. For example, it can be through Figure 1 the device shown that the sample is first provided by the sample supply device 200, the sample is added into the reactor, then the reagent is provided by the reagent supply device 100, and then the reagent is added into the reactor. The sample can be a blood sample. According to different analysis items, the reagent usually includes multiple components, such as magnetic particles, enzyme labels, diluents, dissociating agents, etc. According to different reaction modes, multiple reagent components required for one analysis item can be added into the reactor at one time, or can be added into the reactor in multiple steps respectively.

[0053] In S3, the reactor is shaken to mix the reagent and the sample in the reactor. Of course, in some tests, the mixing step is not required, and in this case, step S3 can be skipped.

[0054] In S4, the mixture of the sample and the reagent in the reactor is incubated, and the incubation time is usually 5 to 60 minutes. The incubation refers to the process of antigen-antibody binding reaction or the process of biotin-avidin binding reaction under a constant temperature environment.

[0055] In S5, washing and separation refers to the process of capturing the magnetic particles after the binding reaction by magnetic force, while removing the unbound labeled antibodies and other unreacted or unbound components.

[0056] In S6, after washing and separation, a signal reagent is continuously added to the reactor for signal incubation for 1 to 6 minutes. Signal incubation refers to the process of adding a signal reagent to the reactor after washing and separation and reacting for a period of time in a constant temperature environment to enhance the signal. Due to the different types of signal reagents, some luminescence systems do not require signal incubation and can directly proceed to the measurement step S7 after adding the signal reagent. There can be one or more signal reagents. Some signal reagents can also include a first component reagent and a second component reagent.

[0057] In S7, the signal reagent reacts with the original mixture in the reactor to produce the luminescence amount of the reactant. Among them, the signal reagent is usually a kind of general reagent, and a general reagent refers to a signal reagent that can be used commonly in different analysis items. Through the above steps, the content of the analyte contained in the sample is quantitatively or qualitatively determined.

[0058] Take Figure 1 the illustrated embodiment as an example. Step S1 is completed by the reactor supply device 300. Step S2 is completed by the reagent supply device 100, the sample supply device 200, the supply unit 700, and the transfer device 500. Step S3 is completed by the mixing unit 800. Steps S4 - S6 are completed by the reaction device 400. The washing and separation assembly

[0059] The reactor supply device 300 is used to store and provide reactors. The reactor supply device 300 can include a tray structure or a bin structure 310. Among them, the tray structure is that the reactors are neatly arranged on a tray; the bin structure 310 is that the reactors are randomly placed in the bin. Since the reactors are neatly arranged in the tray in the tray structure, the tray structure occupies a relatively large space volume. In order to reduce the occupied volume of the reactor supply device 300 and make the overall structure compact, preferably the bin structure 310 is adopted. In one of the embodiments, as Figure 1 shown, the reactor supply device 300 includes a bin structure 310, a sorting structure, and a supply chute 320. The reactors are randomly placed in the bin structure 310, and the sorting structure sorts the randomly placed reactors in the bin so that the reactors pass through the supply chute 320 one by one and are discharged to the supply unit 700. The supply unit 700 is used to cache the reactors.

[0060] Such as Figure 1As shown, in one embodiment, the supply unit 700 includes a supply tray 710 and a supply driving member that drives the supply tray 710 to rotate around the central axis of the supply tray 710. A plurality of temporarily storing grooves 720 for temporarily storing reactors are provided on the outer periphery of the supply tray 710 at circumferentially spaced intervals. The supply driving member drives the supply tray 710 to rotate so that an empty temporarily storing groove 720 is aligned with the supply chute 320 of the reactor supply device 300. After the reactor is transferred from the supply chute 320 to the temporarily storing groove 720, the supply driving member drives the supply tray 710 to rotate so that the next empty temporarily storing groove 720 is aligned with the supply chute 320 of the reactor supply device 300. Among them, at least three temporarily storing grooves 720 are provided. At a certain moment, at least one temporarily storing groove 720 is used to receive the reactor provided by the reactor supply device 300, at least one reactor in the temporarily storing groove 720 receives the sample provided by the sample supply device 200, and the reactor in at least one temporarily storing groove 720 is transferred to the transfer device 600 by the transfer device 600.

[0061] In one embodiment, as Figure 1 shown, the analysis device includes a supply unit 700, a reactor supply device 300, a sample supply device 200, and a transfer device 500 disposed circumferentially of the supply tray 710 in the supply unit 700. The analysis device further includes a transfer device 600 that can transfer the reactor between the supply unit 700 and the transfer device 500. Among them, after the supply unit 700 receives the reactor provided by the reactor supply device 300, the supply tray 710 rotates by an angle and receives the sample provided by the sample supply device 200 so that the sample is added to the reactor; then the supply tray 710 continues to rotate. After the supply tray 710 rotates by a certain angle, the transfer device 600 transfers the reactor containing the sample to the transfer device 500.

[0062] The transfer device 500 is used to carry and transfer the reactor that needs to discharge the reagent. Further, the transfer device 500 is also used to carry and transfer the reactor that needs to be mixed after discharging the reagent. Figure 3 At least a schematic structural diagram of the transfer device 500 included in the analysis device is shown. As Figure 3 shown, the transfer device 500 includes a transfer driving member 510 and a transfer turntable 520 connected to the transfer driving member 510. The transfer turntable 520 is used to carry the reactor. The transfer driving member 510 drives the transfer turntable 520 to rotate around the central axis of the transfer turntable 520 so that the reactor on the transfer turntable 520 moves to different positions. A plurality of temporarily storing positions 530 for temporarily storing reactors are provided on the outer periphery of the transfer turntable 520 at circumferentially spaced intervals. Here, the temporarily storing position 530 can be understood as a groove structure opened on the transfer turntable 520, or can be understood as a fixture fixedly installed on the transfer turntable 520 for clamping the reactor. In one embodiment, a plurality of temporarily storing positions 530 are arranged in a ring on the transfer turntable 520.

[0063] In one embodiment, there are at least four temporary storage positions 530. At a certain moment, at least one temporary storage position 530 is used to receive the reactor transferred by the transfer device 600 from the supply unit 700. The reactor in at least one temporary storage position 530 is used to receive the reagent provided by the reagent supply device 100. The reactor in at least one temporary storage position 530 is used to mix the reagent and the sample, and the reactor in at least one temporary storage position 530 is transferred by the transfer device 600 to the reaction device 400. In one embodiment, as Figure 1 shown, the analysis device includes a transfer device 500, and a supply unit 700, a reagent supply device 100, and a mixing unit 800 arranged circumferentially on the middle turntable 520 of the transfer device 500; the analysis device further includes a reaction device 400 arranged on the outer periphery of the transfer device 500, and a transfer device 600 capable of transferring the reactor between the transfer device 500 and the reaction device 400. After the transfer device 500 receives the reactor containing the sample transferred from the supply unit 700, the middle turntable 520 rotates by an angle and continues to receive the reagent provided by the reagent supply device 100 so that the reagent is added to the reactor containing the sample; then the middle turntable 520 continues to rotate, and the mixing unit 800 mixes the reagent and the sample in the reactor; then the middle turntable 520 continues to rotate, and the transfer device 600 transfers the mixed reactor to the reaction device 400. In order to improve the working efficiency of the middle turntable 520 so that multiple reactors can be temporarily stored on the middle turntable 520, the number of temporary storage positions 530 on the middle turntable 520 can be more than four. At the same time, in order to prevent the middle turntable 520 from having a large volume resulting in a large overall equipment volume, the number of temporary storage positions 530 on the middle turntable 520 is at most eight.

[0064] In one embodiment, the number of temporary storage positions 530 on the middle turntable 520 is 3 - 8. If in one embodiment, the number of temporary storage positions 530 on the middle turntable 520 is less than 3, it is difficult to process multiple tasks in parallel, such as receiving the reactor in and out of the middle turntable 520, receiving the reagent provided by the reagent supply device 100, and mixing the reagent and the sample in the reactor in parallel. If in one embodiment, the number of temporary storage positions 530 in the middle turntable 520 is too many, such as more than 8, it will cause the middle turntable 520 to occupy a large space volume, and it will also cause the reactor to stay on the middle turntable 520 for a long time, reducing the test efficiency.

[0065] In one embodiment, as Figure 3As shown, the mixing unit 800 is disposed below the middle turntable 520. The rotation of the middle turntable 520 enables the reactors in the temporary storage positions 530 on the middle turntable 520 to correspond to the mixing unit 800 in sequence. The mixing unit 800 can vibrate the reactors to mix the reagents and samples in the reactors. For example, the mixing assembly may include a vibrating member 810, a mixing driving member 830 for driving the vibrating member 810 to vibrate, and a lifting driving member. Vibration holes 820 may be provided on the vibrating member 810. The lifting driving member drives the vibrating member 810 and the driving vibrating member 810 to lift, so that the reactor can be inserted into the vibration holes 820. The mixing driving member 830 drives the vibrating member 810 to oscillate eccentrically, so that the reagents and samples in the reactor are mixed evenly due to the oscillation.

[0066] In one embodiment, as Figure 3 shown, when the middle turntable 520 rotates, the temporary storage positions 530 on the middle turntable 520 move synchronously with the middle turntable 520, and each temporary storage position 530 can move to position a, position b, position c, and position d in sequence. Position a may be a transfer position, where the reactor enters and exits the middle turntable 520. Position d may be a mixing position, where the reactor mixes the samples and reagents in the reactor. Position b may be a reagent discharging position, where the reactor receives reagents. Position c may also be a reagent discharging position. When looking down at the middle turntable 520, positions a, b, c, and d are arranged in sequence in the clockwise direction. Among them, the reactor enters and exits the middle turntable 520 at position a. Combining Figure 1 , the reagent supply device 100 discharges reagents to the reactors on the middle turntable 520 at position c, and the mixing unit 800 mixes the reagents and samples in the reactors at position d. The multiple reactors on the middle turntable 520 can be taken away by the transfer device 600 from the middle turntable 520 only after moving to position a in sequence, that is, the transfer device 600 only picks up and places the reactors at position a, which can shorten the length of the transfer trajectory of the transfer device 600, and only one transfer device 600 can be used to pick up and place the reactors, so the number of transfer devices 600 can also be reduced.

[0067] As Figure 1 shown, the transfer trajectory of the transfer device 600 passes through position a. And the center of the middle turntable 520 and position c are on the same side of the transfer trajectory of the transfer device 600. This layout can reduce the space volume occupied by the middle turntable 520 and avoid the space interference between the transfer device 600 and the reagent supply device 100.

[0068] As Figure 1As shown, when the analysis device includes two reagent supply devices 100, the middle turntable 520 can receive the reagents provided by the two reagent supply devices 100 at position b and position c respectively; in some embodiments, the middle turntable 520 can also receive the reagents provided by the two reagent supply devices 100 at position c successively. Preferably, the middle turntable 520 can also receive the reagents provided by the two reagent supply devices 100 at position c successively, which can further reduce the size of the middle turntable 520 and the space occupied by the reagent supply device 100, improve the flexibility and efficiency of the reagent supply device 100, and increase the processing task capacity per unit area of the transfer device 500 and the reagent supply device 100.

[0069] As Figure 1 shown, the middle turntable 520 of the reaction device 400 and the transfer device 500 are independently arranged. Specifically, the transfer device 500 is arranged outside the reaction device 400, and the rotation center of the transfer device 500 is arranged outside the reaction device 400. That is to say, there is no spatial overlap between the transfer device 500 and the reaction device 400 in the top view direction. Further, the diameter of the middle turntable 520 is smaller than the diameter of the reagent disc. This not only avoids problems such as complex structure, high cost, and large occupied area caused by the nested arrangement of the middle turntable 520 and the reaction device 400, but also solves the limitations of the reaction disc 410 of the reaction device 400 on the structure, size, spatial position, and distribution of the temporary storage positions of the middle turntable 520, and can more flexibly, efficiently, and reasonably layout the position of the middle turntable 520 and the temporary storage positions thereon. Among them, the nested arrangement of the middle turntable 520 and the reaction device 400 means that the middle turntable 520 and the reaction device 400 are coaxially arranged, and the reaction device 400 is nested inside the middle turntable 520. In one embodiment, as Figure 1 shown, the reagent supply device 100 includes a reagent storage unit 110 and a reagent discharging unit 120; the reagent storage unit 110 is used for storing reagents, and the reagent discharging unit 120 is used for sucking and discharging the reagents stored in the reagent storage unit 110 to the reactors on the transfer device 500.

[0070] In some embodiments, the reagent storage unit 110 can be a bin structure, that is, a fixed reagent bin, or can be a Figure 1 disc structure as shown, that is, a rotatable reagent disc for storing reagents. Since the middle turntable 520 is used for temporarily storing reactors, and each reactor stays on the middle turntable for a short time, but the reagent disc stores some reagents for a long time. In order to meet the requirements of reagent storage and ensure the small size of the whole machine, the diameter of the middle turntable 520 is set to be smaller than the diameter of the reagent disc.

[0071] The following will be introduced with the disc structure Figure 1The reagent storage unit 110 shown. A number of reagent positions for placing reagent containers are provided on the reagent storage unit 110. The disk-shaped reagent storage unit 110 can be driven by a drive unit under the control of a control center to rotate around the central axis of the reagent storage unit 110, so that the reagent positions on the reagent storage unit 110 can be sequentially rotated to positions where they can be accessed by the reagent discharging unit 120.

[0072] In one embodiment, when the reagent includes a magnetic particle reagent component, since the magnetic particle reagent component will settle naturally, the reagent storage unit 110 may include a mixing structure, and the mixing structure can rotate or vibrate the magnetic particle reagent component container at the reagent position, so as to mix the magnetic particle reagent component in the reagent container.

[0073] In one embodiment, the reagent storage unit 110 may include a refrigerator. When long-term preservation of the reagent is required, the refrigerator can provide a stable low-temperature environment for the reagent in the reagent container, thereby extending the preservation time of the reagent.

[0074] In one embodiment, the reagent storage unit 110 may include a barcode scanner, and the barcode scanner is used to identify the barcode information on the reagent container to identify and distinguish reagents for different analysis items. In order to make the overall machine structure compact and reduce costs, the barcode scanner can adopt a fixed design, for example, it is fixedly arranged relative to the whole machine.

[0075] In a traditional analysis device, usually one reagent storage unit 110 is provided. In order to increase the number of reagent containers accommodated in the reagent storage unit 110, that is, the number of reagent positions, it is necessary to increase the size of the reagent storage unit 110. However, this large-sized reagent storage unit 110 not only occupies a large space area, is inconvenient for the layout of the whole machine, is not conducive to production and manufacturing, but also has high requirements for motion control, that is, any reagent position needs to be positioned to a position where it can be accessed by the reagent discharging unit 120 in a very short time. Therefore, the whole machine cannot operate at high speed.

[0076] For this reason, in one embodiment of the present application, as Figure 1 shown, the analysis device includes at least two independently driven reagent supply devices 100. The reagent storage units 110 in the two reagent supply devices 100 are respectively the first reagent disk 111 and the second reagent disk 112, and the first reagent disk 111 and the second reagent disk 112 are each driven to rotate by an independent drive unit. By independently setting and driving the two reagent supply devices 100, not only is the size of each reagent disk small, which is conducive to the layout of the whole machine and the motion control of the reagent disk, but also the reagent storage quantity of the whole machine is effectively expanded. In addition, the reliability of the operation of the whole machine is improved. When one of the reagent supply devices 100 fails, the other reagent supply device 100 can still be used.

[0077] In an application scenario, it is necessary to load 3 TSH (thyroid stimulating hormone) reagent containers, each containing 100 tests. The 3 TSH reagent containers can all be loaded on the first reagent tray 111; or the 3 TSH reagent containers can all be loaded on the second reagent tray 112; or 1 TSH reagent container can be loaded on the first reagent tray 111 and the other 2 TSH reagent containers can be loaded on the second reagent tray 112; or 1 TSH reagent container can be loaded on the second reagent tray 112 and the other 2 TSH reagent containers can be loaded on the first reagent tray 111. That is to say, the first reagent tray 111 and the second reagent tray 112 can respectively store the reagent components required for a test item. In this way, the two reagent trays can alternately output reagents, shortening the time occupied by reagent extraction and improving work efficiency.

[0078] In one embodiment, in order to fully consider usage requirements, costs, and layouts, 15 - 50 reagent positions are set on each reagent tray. For example, both the first reagent tray 111 and the second reagent tray 112 are provided with 25 reagent positions.

[0079] In one embodiment, as Figure 1 shown, the reagent discharging unit 120 is used for sucking and discharging reagents. For example, the reagent discharging unit 120 sucks reagents from the reagent containers in the reagent storage unit 110 and then discharges the reagents into the reactor in the transfer device 500. As Figure 1As shown, when the test throughput is high, in order to improve the reagent aspiration and discharge efficiency, the reagent discharge units 120 correspond one-to-one with the reagent storage units 110, and the two reagent discharge units 120 are also independently controlled, and alternately discharge reagents into the reactors in the transfer device 500 independently; when the test throughput is not high, one reagent discharge unit 120 can also be provided. Generally, the reagent discharge unit 120 includes a metal needle, a pipetting drive mechanism, a syringe or a liquid injection pump, a valve, a fluid pipeline, etc. In order to complete the reagent aspiration and discharge actions, the reagent discharge unit 120 can perform horizontal movement and vertical movement. The horizontal movement usually has several movement forms such as rotation, X-direction, Y-direction or a combination of several movement forms. As a preferred embodiment, the reagent discharge unit 120 can perform horizontal linear movement and vertical movement, and the horizontal linear movement trajectory is on the line connecting the center of the reagent storage unit 110 and the position c of the middle turntable 520. In particular, two reagent discharge units 120 and two reagent storage units 110 are provided, and the reagent discharge units 120 correspond one-to-one with the reagent storage units 110. The horizontal linear movement trajectories of the two reagent discharge units 120 intersect at the position c of the middle turntable 520 along the radial directions of their respective corresponding reagent storage units 110. The two reagent discharge units 120 alternately discharge reagents into the reactors at the position c of the transfer device 500 independently. This not only minimizes the movement stroke of the reagent discharge unit 120 and improves the efficiency of the processing task, but also makes the overall layout of the machine more reasonable and compact, and reduces the spatial interference of various moving components.

[0080] As Figure 1 shown, the reaction device 400 is used to incubate, wash and separate, and measure the reactants in the reactor. The reaction device 400 includes a reaction disk 410 and a reaction drive member that drives the reaction disk 410 to rotate around its central axis. A number of reaction positions 420 are provided on the reaction disk 410, and the reaction positions 420 can be structures such as holes, grooves, brackets or bases for fixing the reactor. As Figure 4 shown, Figure 4 is a schematic structural diagram of the reaction positions 420 on the reaction device 400 in one embodiment. These reaction positions 420 at least include a washing and separating position 421, an incubation position 422, and a measuring position 423. These reaction positions 420 are arranged in a ring on the reaction disk 410. The inner ring is the washing and separating position 421; the outer ring is the measuring position 423; between the inner ring and the outer ring is the incubation position 422, and several circles of incubation positions 422 are provided. The reactors arranged at the incubation position 422 perform the incubation process, the reactors arranged at the washing and separating position 421 perform the washing and separating process, and the reactors arranged at the measuring position 423 perform the measuring process or prepare for measurement.

[0081] In one of the embodiments, as Figure 4As shown, the reaction sites 420 on the reaction disk 410 are arranged in a group along the radial direction of the reaction disk 410. Each group includes a cleaning and separation site 421, an incubation site 422, and a measurement site 423, and several groups are arranged along the circumferential direction of the reaction disk 410.

[0082] In one embodiment, combined with Figure 1 , the transfer trajectory of the transfer device 600 extends along a radius of the reaction disk 410 and at least covers all the reaction sites along this radius direction on the reaction disk 410. Furthermore, when the reaction disk 410 rotates circumferentially, all the reaction sites 420 on the reaction disk 410 can be covered by the transfer trajectory of the transfer device 600, realizing the problem of picking and placing the reactors on different circles of reaction sites 420, making the overall layout of the machine compact and occupying a small space volume.

[0083] In one embodiment, as Figure 1 shown, the transfer device 500 includes a rotatable transfer disk 520. The centers of the transfer disk 520 and the supply disk 710 are respectively located on both sides of the transfer trajectory of the transfer device 600. With this setting, the transfer disk 520 and the supply disk 710 respectively occupy the spaces on both sides of the transfer device 600, not only shortening the movement stroke of the transfer device 600, but also making the overall layout of the machine compact and occupying a small space volume.

[0084] In one embodiment, as Figure 1 shown, the reaction device 400 includes a temperature control component. The temperature control component includes elements such as a heat preservation pot, a heat insulation device, a heater, a temperature sensor, and a temperature control circuit, providing a constant temperature incubation environment for the reaction device 400 and reducing heat dissipation.

[0085] In one embodiment, the reaction device 400 further includes a cleaning and separation component. As Figure 4As shown, when the reactor at the cleaning and separation position 421 is transferred to the position where the cleaning and separation assembly is located, the cleaning and separation assembly starts to clean and separate the reactor to remove the unbound components in the reactants. The cleaning and separation assembly includes a magnetic assembly and a flushing assembly. Among them, the magnetic assembly provides a magnetic force to collect the magnetic particles in the reactor on the inner wall of the reactor. Due to factors such as the response time, moving distance, and resistance in the magnetic force, it takes a certain amount of time for the magnetic particles to be collected on the inner wall of the reactor, usually ranging from several seconds to dozens of seconds. In this way, before each aspiration of the waste liquid (including unbound components), the reactor needs to be under the magnetic force for a period of time. In this embodiment, the magnetic assembly can be directly installed or fixed near the cleaning and separation position 421, making the magnetic assembly closer to the reaction position 420, reducing the collection time of the magnetic particles, and improving the cleaning and separation efficiency. The flushing assembly is arranged above the cleaning and separation position 421. The flushing assembly includes a liquid suction needle and a liquid suction pipe connected to the liquid suction needle. The liquid suction needle is driven by a liquid suction driving member to enter and exit the reactor at the cleaning and separation position 421 to aspirate the unbound components in the reactor. In one embodiment, the flushing assembly further includes a liquid injection needle and a liquid injection pipe connected to the liquid injection needle. The liquid injection needle is used to inject a cleaning buffer solution into the reactor.

[0086] Generally, each cleaning and separation step includes a process of one liquid suction and one injection of a cleaning buffer solution; generally, three to four cleaning and separation steps are completed. In one embodiment, in order to improve the effect of cleaning and separating the reactor and reduce the reaction residues in the reactor, combined with Figure 4 , a mixer can be provided at the cleaning and separation position 421. The mixer is used to evenly redistribute the magnetic particles in the reactor again after injecting the cleaning buffer solution. The flushing assembly is arranged above the cleaning and separation position 421, and can directly clean and separate the reactor at the cleaning and separation position 421. In this way, there is no need to set up an independent cleaning and separation rotating device, avoiding the transfer of the reactor between the independent cleaning and separation assembly and the reaction device 400. It has the advantages of a simple overall structure and high operation efficiency.

[0087] In one embodiment, the reaction device 400 further includes a measurement component 430, which is disposed on the heat-insulated pot and measures the signals inside the reactor at the measurement position 423. The signals are electrical signals, fluorescence signals, weak chemiluminescence signals, etc. generated after adding signal reagents into the reactor. In one embodiment, the measurement component 430 includes a photomultiplier tube (PMT) for detecting weak light or other sensitive photoelectric induction devices, which can convert the measured optical signals into electrical signals and transmit them to the control center. In addition, in order to improve the measurement efficiency and ensure the measurement consistency, the measurement component 430 may further include optical structures such as optical signal collection and calibration. The measurement component 430 is connected or mounted to the reaction device 400 in a general manner. For example, it is directly mounted and fixed on the reaction device 400 or connected and mounted to the reaction device 400 through an optical fiber. In this way, the signals inside the reactor at the outermost reaction position 420 can be directly measured, avoiding the setting of an independent measurement unit, eliminating the transfer of the reactor between the reaction device 400 and the measurement component 430, and making the overall mechanism of the machine more compact, the cost lower, the control process simpler and more efficient, and the processing efficiency and reliability higher.

[0088] In one embodiment, as Figure 1 shown, an analysis device includes a transfer device 600, which moves the reactor from a first position to a second position along a first direction. The first position is at least one of a supply unit 700, a transfer device 500, and a reaction device 400, and the second position is at least one of a supply unit 700, a transfer device 500, and a reaction device 400. In other embodiments, the first position may also be a structure outside the supply unit 700, the transfer device 500, and the reaction device 400, and the second position may also be a structure outside the supply unit 700, the transfer device 500, and the reaction device 400.

[0089] Figure 5 FIG. is a schematic structural diagram of the transfer device 600 in an embodiment. The transfer device 600 includes a guide rail 630 and a grasping unit moving along the guide rail 630. The spatial path through which the grasping unit moves along the guide rail 630 is the transfer trajectory of the transfer device 600. The number of grasping units can be selected according to actual situations. In order to improve the comprehensive working ability of the transfer device 600, preferably, at least two grasping units are provided, namely a first grasping unit 611 and a second grasping unit 612. As Figure 5As shown, the transfer device 600 is provided with one guide rail 630. A first grasping unit 611 and a first grasping driving member 621 for driving the first grasping unit 611 to slide along the guide rail 630 are provided on the guide rail 630 of the transfer device 600, and a second grasping unit 612 and a second grasping driving member 622 for driving the second grasping unit 612 to slide along the guide rail 630 are provided. The first driving member and the second driving member are independently arranged. Therefore, the movements of the first grasping unit 611 and the second grasping unit 612 are independent of each other. Among them, the guide rail 630 can extend in a first direction, and the first direction generally extends along the horizontal direction. The first grasping unit 611 and the second grasping unit 612 are arranged in sequence along the extending direction of the guide rail 630. In this way, only one guide rail 630 needs to be set to enable the two grasping units to move, and the transfer trajectory of the transfer device 600 is on a straight line. This not only reduces the number of guide rails, but also is beneficial to the spatial layout of the whole machine, prevents spatial interference of multiple transfer devices, solves the problem of large space occupation to avoid interference, and thus reduces the volume of the device while improving the device throughput, making the device more miniaturized. Further, since the running trajectory of the transfer device is on a straight line, the transfer operations of the grasping units are all completed on this straight line trajectory, shortening the total travel of the transfer operations and improving the transfer operation efficiency of the transfer device. In the traditional implementation, usually a corresponding transfer device is set for each transfer operation, or one transfer device is shared for 1 to 2 transfer operations. Since there are usually many transfer operations and they are not on the same trajectory, these setting methods increase the number and spatial distribution of transfer devices. For example, to achieve high-throughput testing, more than 3 transfer devices with a scattered layout are required, which not only makes the whole machine structure complex and large in size, but also inconvenient to control. In the embodiment of the present application, all transfer operations can be completed only by setting one transfer device, which greatly saves the cost of the device, makes the device structure compact, convenient to control, and does not cause interference of different transfer devices in time and space.

[0090] In one embodiment, as Figure 5 shown, the first grasping unit 611 and the second grasping unit 612 of the grasping unit have the same structure, and both include a frame body, a lifting block and a clamping jaw. The frame body is slidably connected to the guide rail 630. For example, the frame body can slide relative to the guide rail 630 along the horizontal direction. The lifting block is slidably connected to the frame body in the vertical direction, and the clamping jaw is arranged on the lifting block. The clamping jaw can lift with the lifting block to clamp the reactor.

[0091] Figure 6The transfer trajectory diagram of the transfer device 600 in an embodiment. An analysis device includes a transfer device 600, and the transfer device 600 includes a first grasping unit 611 and a second grasping unit 612. The straight lines where the moving trajectories of the first grasping unit (611) and the second grasping unit (612) are located coincide. The grasping unit of the transfer device 600 can pick and place reactors at the cleaning and separation alignment 631, incubation alignment 632, measurement alignment 633, discard alignment 634, relay alignment 635, and transfer alignment 636 along the guide rail 630. In combination with Figure 1 In the shown embodiment, the reaction positions 420 on the reaction device 400 at least include a cleaning and separation position 421, an incubation position 422, and a measurement position 423. When the cleaning and separation position 421 corresponds to the cleaning and separation alignment 631 of the transfer device 600, the grasping unit can pick and place the reactor at the cleaning and separation position 421. When the incubation position 422 corresponds to the incubation alignment 632 of the transfer device 600, the grasping unit can pick and place the reactor at the incubation position 422. When the measurement position 423 corresponds to the measurement alignment 633 of the transfer device 600, the grasping unit can pick and place the reactor at the measurement position 423. In combination with Figure 3 In the shown embodiment, the temporary storage position 530 on the transfer device 500 can at least move to position a, and position a can be a transfer position. When the transfer position corresponds to the transfer alignment 636, the grasping unit can pick and place the reactor at the transfer position. As Figure 1 shown, a relay position can be set between the transfer device 500 and the reaction device 400. The relay position can correspond to the relay alignment 635. The first grasping unit 611 can grasp the reactor at the cleaning and separation alignment 631 and place the reactor on the relay position at the relay alignment 635. Then, the second grasping unit 612 grasps the reactor on the relay position at the relay alignment 635 and then moves the reactor to the transfer alignment 636. In combination with Figure 3 In the shown embodiment, the temporary storage position 530 on the transfer device 500 can move to positions b, c, and d. Position d can be a mixing position, position b can be a reagent discharging position, and position c can also be a reagent discharging position. In combination with Figure 1 In the shown embodiment, a discard position can be set between the reaction device 400 and the transfer device 500. When the discard position corresponds to the discard alignment 634, the grasping unit can pick and place the reactor at the discard position, or the grasping unit can discard the reactor to the discard position.

[0092] In one of the embodiments, in combination with Figure 6 , the straight lines where the moving trajectories of the first grasping unit (611) and the second grasping unit (612) are located coincide, and at least one section of the transfer trajectory of the first grasping unit 611 and the transfer trajectory of the second grasping unit 612 overlap. For example, in Figure 6Among them, the moving trajectories of the first grasping unit 611 and the second grasping unit 612 overlap at the incubation alignment 632, the measurement alignment 633, the discard alignment 634, and the relay alignment 635. For example, the first grasping unit 611 can grasp the reactor from the cleaning and separation alignment 631 and then place the reactor on the relay alignment 635. The second grasping unit 612 can move the reactor placed on the relay alignment 635 to the transfer alignment 636. In combination with Figure 6 , the sorting of the cleaning and separation alignment 631, the incubation alignment 632, the measurement alignment 633, the discard alignment 634, the relay alignment 635, and the transfer alignment 636 does not necessarily follow the Figure 6 shown order and can be rearranged as needed.

[0093] As Figure 1 shown, when the analysis device is working, each sub-device works in an orderly manner according to the working cycle. The working cycle, or simply the cycle, is the shortest time interval that can be cyclically reproduced during the working process of the execution object, and it usually has a fixed time length. For example, the aspiration and discharge steps, the mixing steps, the cleaning and separation steps, and the measurement steps all take time and are executed serially or in parallel in a controlled order. The specific meaning of parallel is that multiple task operations can be carried out simultaneously; it can also be that when the prior task operation has started and not ended, the subsequent task operation starts. Since the same component usually can only execute one task at a time, therefore, the same component usually performs serial actions or tasks within one cycle; different components can usually execute tasks simultaneously, so different components can usually perform actions or tasks in parallel within the same cycle.

[0094] To improve work efficiency, for a device with a speed bottleneck, it can be achieved by increasing the number of devices. For example Figure 1 shown, there are two reagent trays, namely the first reagent tray 111 and the second reagent tray 112. Another example is that it can also be achieved by extending the working cycle of the device. When there is only one reagent tray, the working cycle length required by one reagent tray may be twice the working cycle length of the two reagent trays working together.

[0095] In one of the embodiments, as Figure 1 shown, the analysis device includes two groups of reagent supply devices 100, a transfer device 500, and a transfer device 600. One group of reagent supply devices 100 includes a first reagent tray 111 and a first reagent discharging element 121, and the other group of reagent supply devices 100 includes a second reagent tray 112 and a second reagent discharging element 122, where the first reagent discharging element 121 and the second reagent discharging element 122 are both reagent discharging units 120.

[0096] As Figure 7 shown, Figure 7It is a period length diagram of an analysis device in an embodiment. The transfer device 500 and the transfer unit 600 operate in the first period T1, and the first row of reagent elements 121 and the second row of reagent elements 122 operate in the second period T2. The time length of the second period T2 is twice the time length of the first period T1. The first row of reagent elements 121 and the second row of reagent elements 122 operating in the second period T2 stagger by a time length of the first period T1 and alternately discharge reagents to the reactor at the same temporary storage position 530 of the transfer device 500. As Figure 7 shown, when starting continuous operation, the transfer unit 600 transfers one reactor into the transfer device 500 every first period T1. The transfer device 500 drives the reactor to rotate and advance one position every first period T1. The first row of reagent elements 121 sucks reagents from the first reagent tray 111 and discharges the reagents to the reactor on the transfer device 500 every second period T2. For example, for the convenience of understanding, sucking reagents corresponds to section A in the second period T2, and discharging reagents corresponds to section B in the second period T2. The second row of reagent elements 122 sucks reagents from the second reagent tray 112 and discharges the reagents to the reactor on the transfer device 500 every second period T2. Similarly, sucking reagents corresponds to section A in the second period T2, and discharging reagents corresponds to section B in the second period T2. The same action sequences of the first row of reagent elements 121 and the second row of reagent elements 122 are staggered by a first period T1, that is, when the first row of reagent elements 121 sucks reagents, the second row of reagent elements 122 discharges reagents; when the first row of reagent elements 121 discharges reagents, the second row of reagent elements 122 sucks reagents. Specifically, the first row of reagent elements 121 and the second row of reagent elements 122 can discharge reagents to the reactors at the same position of the transfer device 500. That is to say, the transfer device 500 transfers one of the reactors to a specific position to receive the reagents discharged by the first row of reagent elements 121 in the Nth first period, and the transfer device 500 transfers another reactor to this specific position and receives the reagents discharged by the second row of reagent elements 122 in the (N + 1)th first period. As Figure 1 shown, this specific position can be position c. In Figure 1In this case, the movement trajectories of the first row of reagent elements 121 and the second row of reagent elements 122 can both cover position c, that is, they coincide or intersect at position c. Such a setting makes the area covered by the first row of reagent elements 121 and the second row of reagent elements 122 small, making the overall machine structure more compact. In the above embodiments, the working cycle of the reagent storage unit 110 is the same as that of the first row of reagent elements 121 and the second row of reagent elements 122, and is twice the working cycle of the transfer device 500 and the transfer device 600. The action sequences between the two groups of reagent storage units 110 are staggered and parallel, with a difference of one first cycle T1. In this way, the analysis device only includes two groups of reagent storage units 110, one group of transfer devices 500 and one group of transfer devices 600, which not only reduces the occupied space of the device, but also effectively improves the working efficiency of the analysis device.

[0097] An embodiment of the present application further provides a dilution device, as Figure 8 shown, Figure 8 is a schematic structural diagram of a dilution device in an embodiment. The dilution device includes a reagent supply device 100, a sample supply device 200, a reactor supply device 300, a transfer device 500, a transfer device 600, a supply unit 700, and a dilution transport device 900. Among them, the reagent supply device 100, the sample supply device 200, the reactor supply device 300, the transfer device 500, the transfer device 600, and the supply unit 700 have the same structure as those in the above embodiments. The dilution transport device 900 is arranged between the reaction device 400 and the transfer device 500. The transportation distance of the reactor containing the diluted sample can be reduced. At least one carrying position is arranged on the dilution transport device 900 for carrying the reactor containing the diluted sample, and it can move linearly back and forth between the movement trajectories of the transfer device 600 and the sample supply device 200. Preferably, at least two carrying positions are arranged on the dilution transport device 900 for carrying the reactors containing the diluted sample, which can be used alternately to improve the efficiency of automatic sample dilution.

[0098] As Figure 8 shown, a first working position 11 and a second working position 12 are arranged on the supply unit 700 of the dilution device. The first working position 11 is used for the first reactor to receive the sample and the second reactor to receive the diluted sample, and the second working position 12 is used for the transfer device 600 to transfer the first reactor and the second reactor out of the supply unit 700. A fourth working position 14, a fifth working position 15, and a sixth working position 16 are arranged on the transfer device 500. The fourth working position 14 is used for the transfer device 600 to move the first reactor and the second reactor into and out of the transfer device 500. The fifth working position 15 is used for the first reactor to receive the diluent and the second reactor to receive the reagent. The sixth working position 16 is respectively used for mixing the reactants in the first reactor and the second reactor.

[0099] As Figure 8As shown in the figure, the supply unit 700 includes a supply tray 710. A temporary storage tank 720 for accommodating the reactor is provided on the supply tray 710. The supply tray 710 can rotate to drive the temporary storage tank 720 to move cyclically between the first station 11 and the second station 12; the transfer device 500 includes a middle turntable 520. A temporary storage position 530 for accommodating the reactor is provided on the middle turntable 520. The middle turntable 520 can rotate to drive the temporary storage position 530 to move cyclically between the fourth station 14, the fifth station 15 and the sixth station 16. Specifically, the transfer device 600 is used to transfer the reactor between the supply unit 700 and the transfer device 500, and the transfer device 600 can also transfer the reactor between the transfer device 500 and the dilution transportation device 900. The reagent supply device 100 is used to add diluent to the reactor. The sample supply device 200 is not only used to discharge the sample, but also used to transfer the diluted sample between different reactors. For example, the sample supply device 200 includes a movable suction needle, through which the sample can be sucked and discharged, and the diluted sample can also be sucked and discharged. The diluent for a certain item can be a component of the reagent for this item or a kind of general diluent. The diluent is stored in the reagent supply device 100.

[0100] A dilution method can be completed by a dilution device and also by the analysis device in the above embodiment. The dilution method includes the following steps:

[0101] S101. Add a sample to the first reactor at the first station 11 of the supply unit 700.

[0102] The first reactor can be provided to the supply unit 700 by the reactor supply device 300 first, and then the first reactor is moved to the first station 11 of the supply unit 700. The sample can be added to the first reactor at the first station 11 by the sample supply device 200.

[0103] S102. Transfer the first reactor to the fifth station 15 of the transfer device 500, and the first station 11 of the supply unit 700 receives the second reactor.

[0104] The supply unit 700 rotates to rotate the first reactor out of the first station 11. When the supply unit 700 rotates, it drives the second reactor into the first station 11. The reactor on the supply unit 700 can be transferred to the transfer device 500 by the transfer device 600, and the transfer device 500 rotates to transfer the first reactor to the fifth station 15.

[0105] S103. Add diluent to the first reactor at the fifth station 15 to obtain a diluted sample.

[0106] The diluent can be added to the first reactor at the fifth station 15 by the reagent supply device 100 to obtain a diluted sample.

[0107] S104. Mix the diluted sample in the first reactor.

[0108] A mixing unit 800 can be set up to mix the diluted sample in the first reactor at the fifth station 15. Alternatively, the transfer device 500 can be rotated to move the first reactor to other stations for mixing.

[0109] S105. Transfer the first reactor from the transfer device 500 to the dilution transport device 900.

[0110] The first reactor can be transferred from the transfer device 500 to the dilution transport device 900 through the transfer device 600.

[0111] S106. Transfer a part of the diluted sample in the first reactor to the second reactor.

[0112] A part of the diluted sample in the first reactor on the dilution transport device 900 is aspirated by the sample supply device 200 and then discharged into the second reactor on the transfer device 500.

[0113] S107. Transfer the second reactor to the fifth station 15 of the transfer device 500 and continue to add reagents to the second reactor.

[0114] The second reactor can be transferred to the fifth station 15 of the transfer device 500 through the transfer device 600, and reagents continue to be added to the second reactor.

[0115] S108. Mix the mixture in the second reactor.

[0116] The mixture in the second reactor at the fifth station 15 can be mixed. Alternatively, the transfer device 500 can be rotated to move the second reactor to other stations for mixing.

[0117] In the above embodiments, by temporarily storing the reactor containing the dilution in the dilution transportation device 900, and then transferring the mixture in the reactor on the dilution transportation device 900 to the reactor on the supply unit 700 through the sample supply device 200. Therefore, it is not necessary to temporarily store the diluted reactor back to the supply unit 700, which can effectively reduce the workload of the supply unit 700 and improve the operation efficiency and stability of the entire device. Further, the dilution transportation device 900 is independently arranged between the reaction device 400 and the transfer device 500, only carrying the transportation of the reactor containing the diluted sample, and moving linearly between the trajectories of the transfer device 600 and the sample supply device 200, without being restricted by other dilution processes and operations such as sample addition, reagent addition, and mixing, which can maximize the efficiency of the dilution device to automatically dilute the sample.

[0118] In some embodiments, the supply disk 710 rotates to drive the temporary storage tank 720 to circulate and move between the first station 11 and the second station 12. The middle turntable 520 drives the temporary storage position 530 to circulate and rotate between the fourth station 14 and the fifth station 15. The supply disk 710 and the middle turntable 520 cooperate to rotate, transferring the reactors in an orderly manner, improving the work efficiency.

[0119] In one embodiment, the reactor can receive the diluent or reagent at the fifth station 15 and perform the mixing operation at the fifth station 15. In one embodiment, the reactor receives the diluent or reagent at the fifth station 15 and performs the mixing operation at the sixth station 16.

[0120] In one of the embodiments, it further includes the step of discarding the first reactor after transferring a part of the diluted sample in the first reactor to the second reactor.

[0121] In one of the embodiments, a sample analysis method is provided, including the following steps:

[0122] S210: Add the sample and the first reagent to the reactor and mix well.

[0123] S220: Incubate the reactor containing the sample and the first reagent at the incubation position 422 of the reaction disk 410 for the first time.

[0124] S230: Transfer the reactor after the first incubation to the cleaning and separation position 421 of the reaction disk 410 for the first cleaning and separation.

[0125] S240: Transfer the reactor to the middle turntable 520, add the second reagent and mix well.

[0126] S250: Transfer the reactor added with the second reagent to the incubation position 422 of the reaction disk 410 for the second incubation.

[0127] S260. Transfer the reactor after the second incubation to the cleaning and separation position 421 of the reaction plate 410 for the second cleaning and separation.

[0128] S270. Add a signal reagent to the reactor.

[0129] S280. Transfer the reactor added with the signal reagent to the measurement position 423 of the reaction plate 410 for measurement.

[0130] In one embodiment, it further includes the step of transferring the reactor after measurement to the discard position to discard the reactor.

[0131] Specifically, in step S210, it further includes the following steps:

[0132] S211. Provide a reactor and add a sample to the reactor.

[0133] S212. Transfer the reactor containing the sample to the middle turntable 520 and add a first reagent;

[0134] S213. Shake the reactor to mix the sample and the first reagent in the reactor.

[0135] Specifically, in step S220, it further includes the following steps:

[0136] S221. Transfer the reactor containing the mixed sample and the first reagent from the middle turntable 520 to the incubation position 422 of the reaction plate 410;

[0137] S222. The reactor containing the sample and the first reagent rotates with the reaction plate 410 and undergoes the first incubation. The incubation time can be set according to specific test items, generally 3 minutes to 60 minutes.

[0138] In step S230, the reactor rotates with the reaction plate 410, and the reactor is subjected to the first cleaning and separation by the cleaning and separation assembly.

[0139] In one of the embodiments, a sample analysis device is provided, which can complete the above sample analysis method. As Figure 1 shown, the sample analysis device at least includes a supply device, a mixing unit 800, a reaction device 400, a transfer device 600, a cleaning and separation assembly, and a signal reagent adding assembly. The supply device includes a sample supply device 200 and a reagent supply device 100. Among them, the sample supply device 200 in the supply device is used to add a sample to the reactor, and the reagent supply device 100 is used to add a reagent to the reactor. The following embodiments introduce the steps of completing the sample analysis method through the sample analysis device.

[0140] In step S210, a reactor is provided to the supply tray 710 through the reactor supply device 300. The supply tray 710 can rotate around the center of the supply tray 710. When the reactor rotates to the station corresponding to the sample supply device 200, the sample supply device 200 provides a sample into the reactor. When the supply tray 710 rotates the reactor to the working range of the transfer device 600, the transfer device 600 transfers the reactor from the supply tray 710 to the middle turntable 520. A temporary storage position 530 for carrying the reactor is provided on the middle turntable 520, and the middle turntable 520 can also rotate around the central axis of the middle turntable 520. The middle turntable 520 rotates the reactor to the position corresponding to the reagent supply device 100, and the first reagent is supplied into the reactor through the reagent supply device 100. The middle turntable 520 rotates the reactor to the position of the mixing unit 800, and the mixing unit 800 mixes the sample and the first reagent in the reactor. Then the middle turntable 520 rotates the reactor to the working range of the transfer device 600, and the reactor is transferred to the reaction device 400 through the transfer device 600.

[0141] In step S220, the reaction device 400 includes a reaction tray 410. Reaction positions 420 for carrying the reactor are provided on the reaction tray 410. The reaction positions 420 are arranged in a ring on the reaction tray 410. According to the different functions of the reaction positions 420, the reaction positions 420 can be divided into incubation positions 422 for incubation, cleaning and separation positions 421 for cleaning and separation, and measurement positions 423 for measurement. The transfer device 600 can transfer the reactor among the incubation positions 422, the cleaning and separation positions 421, and the measurement positions 423. During the first incubation, the reactor undergoes the first incubation at the incubation position 422.

[0142] In step S230, the reaction device 400 includes a cleaning and separation assembly. After the first incubation is completed, the reactor is transferred from the incubation position 422 to the cleaning and separation position 421 through the transfer device 600, and the reactor at the cleaning and separation position 421 is subjected to the first cleaning and separation through the cleaning and separation assembly.

[0143] In step S240, the transfer device 600 transfers the reactor to the middle turntable 520. The middle turntable 520 rotates the reactor to the station corresponding to the reagent supply device 100, and the second reagent is added to the reactor through the reagent supply device 100. The middle turntable 520 continues to rotate the reactor to the position corresponding to the mixing unit 800, and the mixture in the reactor is mixed through the mixing unit 800. The middle turntable 520 continues to rotate the reactor to the working range of the transfer device 600.

[0144] In step S250, the transfer device 600 transfers the reactor added with the second reagent to the incubation position 422 of the reactor for the second incubation.

[0145] In step S260, the transfer device 600 transfers the reactor after the second incubation to the cleaning and separation position 421 of the reaction plate 410 for the second cleaning and separation by the cleaning and separation assembly.

[0146] In step S270, the reaction device 400 includes a signal reagent adding assembly, and a signal reagent is added to the reactor through the signal reagent adding assembly.

[0147] In step S280, the reactor is transferred to the measurement position 423 through the transfer device 600 for measurement.

[0148] In some embodiments, the reactor after measurement is transferred to the discard position through the transfer device 600 to discard the reactor.

[0149] In the sample analysis method in the above embodiments, the reactor needs to be transferred multiple times. The above sample analysis method can be implemented in a sample analysis device. When the sample analysis device performs sample analysis, multiple groups of tests are usually carried out, and multiple groups of tests all require the transfer of the reactor. In order to improve work efficiency and enable the sample analysis device to make full use of working time, a reactor transfer method is provided:

[0150] The transfer device completes at least 5 transfer operations. Each transfer operation transfers a reactor between two different operation stations. There are at least two mutually exclusive transfer operations in the transfer operations. The mutually exclusive transfer operations do not exist simultaneously in the same working cycle and the beats overlap in different working cycles.

[0151] The beat is the time period occupied when each transfer operation is executed within a working cycle. The length of each beat may be the same or different. Multiple beats in a cycle may be continuous or intermittent, and the order of multiple beats is fixed. If the transfer operation corresponding to a certain beat does not exist in a certain working cycle, then the beat is idle. Beat overlap means that the time periods within the cycle occupied when the transfer operations are executed in different working cycles at least partially overlap, which can be the overlap of partial execution time periods or complete overlap.

[0152] The operation stations at least include a supply alignment position for removing an empty reactor or a reactor with added sample, a transfer alignment position for moving in a reactor that needs to be added with reagent or moving out a reactor with added reagent, an incubation alignment position for moving in a reactor that needs to be incubated or moving out a reactor that has been incubated for a period of time or incubated, and a cleaning alignment position for moving in a reactor that needs to be cleaned and separated or a reactor that has been cleaned and separated.

[0153] In some embodiments, when multiple groups of tests are performed in parallel, the following transfer operations may be required:

[0154] The first transfer operation: Move the empty or sample - emptied reactor from the supply tray 710 to the middle turntable 520;

[0155] The second transfer operation: Move the reactor to be incubated from the middle turntable 520 to the incubation position 422 of the reaction tray 410;

[0156] The third transfer operation: Move the reactor to be cleaned and separated from the incubation position 422 of the reaction tray 410 to the cleaning and separation position 421 of the reaction tray 410;

[0157] The fourth transfer operation: Move the reactor to which the second reagent needs to be added from the incubation position 422 of the reaction tray 410 to the middle turntable 520;

[0158] The fifth transfer operation: Move the reactor to which the second reagent needs to be added from the cleaning and separation position 421 of the reaction tray 410 to the middle turntable 520;

[0159] The sixth transfer operation: Move the reactor to be measured from the cleaning and separation position 421 of the reaction tray 410 to the measurement position 423 of the reaction tray 410;

[0160] The seventh transfer operation: Move the reactor containing the diluted sample from the middle turntable 520 to the dilution transport device 900;

[0161] The eighth transfer operation: Move the reactor after measurement from the measurement position 423 of the reaction tray 410 to the discard position.

[0162] In the above - mentioned embodiment, a transfer device 600 including a first grasping unit 611 and a second grasping unit 612 is provided. The fifth transfer operation moves the reactor to which the second reagent needs to be added from the cleaning and separation position 421 of the reaction tray 410 to the middle turntable 520. If it is only completed by the first grasping unit 611, not only is the movement stroke large, but when the first grasping unit 611 performs the operation, the second grasping unit 612 also needs to avoid, and the two cannot work in parallel, affecting the working efficiency of the transfer device 600. Therefore, the fifth transfer operation is decomposed into two relay - capable sub - operations: the fifth A transfer operation and the fifth B transfer operation. The fifth A transfer operation first needs to transfer the reactor to the relay alignment position 635 by the first grasping unit 611 and place the reactor at the relay position. The fifth B transfer operation is for the second grasping unit 612 to grasp the reactor from the relay position to the transfer alignment position 636. As Figure 6 shown, the second grasping unit 612 is responsible for the first transfer operation, the second transfer operation, the fourth transfer operation, the fifth B transfer operation, the seventh transfer operation, and the eighth transfer operation, and the first grasping unit 611 is responsible for the third transfer operation, the fifth A transfer operation, and the sixth transfer operation.

[0163] In one embodiment, in a two-step test, the following transfer operations need to be performed sequentially:

[0164] The first transfer operation, the second transfer operation, the third transfer operation, the fifth transfer operation, the second transfer operation, the third transfer operation, the sixth transfer operation, and the eighth transfer operation. Therefore, the first transfer operation, the second transfer operation, the third transfer operation, the fifth transfer operation, the second transfer operation, the third transfer operation, the sixth transfer operation, and the eighth transfer operation are sequentially completed by the following grasping units: the second grasping unit 612, the second grasping unit 612, the first grasping unit 611, the first grasping unit 611, and the second grasping unit 612, the second grasping unit 612, the first grasping unit 611, the first grasping unit 611, the second grasping unit 612.

[0165] For the reactor transfer operation of the same functional station, the grasping unit first moves the reactor in the station out and then moves another reactor in. This can improve the usage efficiency of the functional station. Figure 9 The execution action diagram of the grasping unit in a certain cycle in one embodiment is shown. In other embodiments, the execution actions may be different from Figure 9 the state shown. As Figure 9 shown, the first transfer operation: move the empty or sample-drained reactor from the supply tray 710 to the middle turntable 520; the fourth transfer operation: move the reactor that needs to add the second reagent from the incubation position 422 of the reaction tray 410 to the middle turntable 520; the fifth B transfer operation: the second grasping unit 612 grabs the reactor from the relay position to the middle turntable 520. Since all three move from other positions to the middle turntable 520, and the middle turntable 520 can only receive reactors moved in from one position at a time, the first transfer operation, the fourth transfer operation, and the fifth B transfer operation are mutually exclusive.

[0166] Again, as Figure 9 shown, the second transfer operation: move the reactor that needs to be incubated from the middle turntable 520 to the incubation position 422 of the reaction tray 410; the seventh transfer operation: move the reactor containing the diluted sample from the middle turntable 520 to the dilution transport device 900. Since both move the reactor out of the middle turntable 520 to other positions, and the middle turntable 520 can only move the reactor out to one other position at a time, the second transfer operation and the seventh transfer operation are mutually exclusive.

[0167] Again, as Figure 9As shown, the sixth transfer operation: transfer the reactor to be measured from the cleaning and separation position 421 of the reaction disk 410 to the measurement position 423 of the reaction disk 410; the fifth A transfer operation: transfer the reactor to which the second reagent needs to be added from the cleaning and separation position 421 of the reaction disk 410 to the relay position. Since both transfer the reactor from the cleaning and separation position 421 of the reaction disk 410 to other positions (including different positions of the reaction disk 410 itself), and only one reactor can be removed from the cleaning and separation position 421 of the reaction disk 410 to another position at a time, the sixth transfer operation and the fifth A transfer operation are also mutually exclusive.

[0168] There is a same work station among the above mutually exclusive transfer operations.

[0169] Among them, the Figure 9 specific work content of the transfer operation above is only an example. In other embodiments, the specific work corresponding to the transfer operation may not be the content listed in the above embodiments.

[0170] For another example, Figure 10 is the execution action diagram of the grasping unit in a certain cycle when the transfer device 600 has only one grasping unit. Figure 11 is Figure 10 the execution action diagram of the shown embodiment when multiple tests are carried out in parallel. Figure 10 The first transfer operation, the fourth transfer operation and the fifth transfer operation in Figure 10 are mutually exclusive. Of course, the same type of transfer operation is also mutually exclusive. For example, the first transfer operation and the first transfer operation are mutually exclusive. Mutually exclusive transfer operations cannot be executed simultaneously in the same cycle. Among them,

[0171] Now, taking the Figure 10 and Figure 11 shown embodiments as an example, introduce the specific steps of the reactor transfer method:

[0172] As Figure 10 shown, each cycle T includes three consecutive beats, namely beat 1, beat 2 and beat 3. The first transfer operation, the fourth transfer operation and the fifth transfer operation can only be completed in beat 1 of a certain cycle respectively. The third transfer operation can only be completed in beat 2 of each cycle. The second transfer operation can only be completed in beat 3 of each cycle.

[0173] In one of the embodiments, as Figure 11As shown, taking the first to eighth test items in the Mth to Nth cycles as an example, the reactor transfer method with multiple tests in parallel will be described. It should be noted that the first to eighth test items are only identifiers of the test items and do not necessarily represent the actual start order of the tests. These items may be the same test item, or different test items, or partially the same test items. The reactor transfer method includes the parallel first test item, second test item, third test item, fourth test item, fifth test item, sixth test item, seventh test item, and eighth test item. Each test item includes three consecutive beats in each cycle. Each test item includes a number of consecutive transfer operations, where:

[0174] The first test item includes at least the consecutive first transfer operation, second transfer operation, and third transfer operation. The first transfer operation can only be completed in beat 1 of a certain cycle, the second transfer operation can only be completed in beat 3 of each cycle, and the third transfer operation can only be completed in beat 2 of each cycle;

[0175] The second test item includes at least the consecutive fifth transfer operation and second transfer operation. The fifth transfer operation can only be completed in beat 1 of a certain cycle, and the second transfer operation can only be completed in beat 3 of each cycle;

[0176] The third test item includes at least the consecutive fourth transfer operation and second transfer operation. The fourth transfer operation can only be completed in beat 1 of each cycle;

[0177] The fourth test item includes at least the third transfer operation. The third transfer operation can only be completed in beat 2 of each cycle;

[0178] The fifth test item includes at least the second transfer operation. The second transfer operation can only be completed in beat 3 of each cycle;

[0179] The sixth test item includes at least the third transfer operation. The third transfer operation can only be completed in beat 2 of each cycle;

[0180] The seventh test item includes at least the third transfer operation. The third transfer operation can only be completed in beat 2 of each cycle;

[0181] The eighth test item includes at least the first transfer operation. The first transfer operation can only be completed in beat 1 of a certain cycle.

[0182] As Figure 10 shown, the first transfer operation, fourth transfer operation, and fifth transfer operation are mutually exclusive.

[0183] The following takes the first test item and the second test item as examples for illustration. When the first test item and the second test item are executed simultaneously, it is judged whether there is a transfer operation exclusive to the first test item in each cycle of the first test item for the second test item. If there is no exclusive transfer operation in the corresponding cycle, the first test item and the second test item are executed simultaneously. If there is an exclusive transfer operation in the corresponding cycle, when the first test item is executed, it is successively judged to start executing the second test item one cycle later until there is no transfer operation exclusive to the first test item for the second test item in each cycle of the first test item, and then the second test item starts to be executed. Specifically, when the first test item and the second test item are executed simultaneously, in the Mth cycle of the first test item, the second test item has a fifth transfer operation, and the first test item has a first transfer operation. Also, since the fifth transfer operation and the first transfer operation are exclusive, at this time, the situation of starting to execute the second test item one cycle later is judged, as Figure 11 shown. When starting to execute the second test item one cycle later, in the Mth cycle, (M + 1)th cycle, (M + 2)th cycle... Nth cycle of the first test item, there is no transfer operation exclusive to the first test item for the second test item in the corresponding cycle. Therefore, the second test item can be executed one cycle later relative to the first test item.

[0184] The subsequent test items are executed in the same way. That is to say, the reactor transfer method described ultimately aims to ensure that the exclusive transfer operations in these test items do not exist simultaneously in the same working cycle, where the beats in different working cycles overlap. And there are the following two situations where the exclusive transfer operations in these test items do not exist simultaneously in the same working cycle:

[0185] The first situation is: when judging that the Xth test item and the Yth test item are executed simultaneously, it is judged whether there is a transfer operation exclusive to the Xth test item for the Yth test item in each cycle of the Xth test item. If there is no exclusive transfer operation in the corresponding cycle, the Xth test item and the Yth test item are executed in parallel;

[0186] The second case is as follows: If there are mutually exclusive transfer operations in the corresponding period, when the Xth test item is executed, it is sequentially determined that the Yth test item starts to be executed one cycle later each time, until there are no transfer operations mutually exclusive with the Xth test item in the Yth test item in each cycle of the Xth test item, and then the Yth test item starts to be executed. According to the above embodiments, the mutually exclusive transfer operations can share the same beat in different cycles and do not exist simultaneously in the same cycle. On the one hand, there is no need to separately set beats for the mutually exclusive transfer operations in the same cycle, which shortens the cycle time and improves the test throughput. On the other hand, for the mutually exclusive transfer operations, they can be implemented by setting them in different cycles. Therefore, once each test item starts to be executed, it will not be interrupted due to encountering mutually exclusive transfer operations in the middle, and thus can be executed coherently.

[0187] According to the above embodiments, in other embodiments, the first test item, the second test item, the third test item, etc. that are sequentially performed can also be set. In this case, the reactor transfer method at least includes the first test item and the second test item that are successively performed. The first test item includes at least three transfer operations, the second test item includes at least three transfer operations, and there are at least mutually exclusive transfer operations in the first test item and the second test item. The reactor transfer method includes the following steps:

[0188] In each execution cycle of the first test item, sort the beats of the transfer operations of the first test item in the execution order, where the beat is the time period required for each transfer operation;

[0189] In each execution cycle of the first test item, sequentially determine that when the second test item starts to be executed one execution cycle later each time, whether there are mutually exclusive transfer operations between the first test item and the second test item in each beat of the first test item. If there are no mutually exclusive transfer operations between the first test item and the second test item in the same beat, start to execute the second test item.

[0190] In one of the embodiments, the beats of the mutually exclusive transfer operations partially overlap, and the beat is the time period required for each transfer operation. For example, in one of the embodiments, as Figure 10 shown, the beat of the first transfer operation starts to be executed at the first second and ends at the fifth second; the beat of the fourth transfer operation starts to be executed at the second second and ends at the seventh second. Then this group of mutually exclusive transfer operations overlaps between the second second and the fifth second.

[0191] In one of the embodiments, the beats of the mutually exclusive transfer operations completely overlap, and the beat is the time period required for each transfer operation. For example, in one of the embodiments, as Figure 10As shown, the beat of the first transfer operation starts at the first second and is completed at the fifth second; the beat of the fourth transfer operation starts at the first second and is completed at the fifth second. Then the beats of this group of mutually exclusive transfer operations are completely overlapped.

[0192] In one embodiment, there is at least the same operation station for the mutually exclusive transfer operations. For example, for the reactor transfer operations of the same functional station, one transfer operation is to move a reactor into the station by a grasping unit, and the mutually exclusive transfer operation is to move another reactor into the station by the grasping unit. Since the station can only receive the entry of one reactor at the same time, these two transfer operations are mutually exclusive.

[0193] In some embodiments, the above-mentioned transfer operations can be completed by a transfer device. The transfer device 600 may include a first grasping unit 611 and a second grasping unit 612; in some embodiments, the transfer device 600 may also include a grasping unit. When the transfer device 600 includes the first grasping unit 611 and the second grasping unit 612, at least a part of the transfer trajectories of the first grasping unit 611 and the second grasping unit 612 overlaps. Among them, the overlapping transfer trajectories cover at least two stations. For example, as Figure 6 shown, the incubation alignment 632, the measurement alignment 633, the discard alignment 634 and the relay alignment 635 are overlapped, and the transfer trajectories of the corresponding overlapping parts cover the incubation position 422, the measurement position 423, the discard position and the relay position.

[0194] In one embodiment, the covered stations at least include the relay position. The reactor is grasped to the relay position by the first grasping unit 611, and then the reactor is transferred from the relay position to other positions by the second grasping unit 612, so as to realize the transfer of the reactor on both sides of the relay position.

[0195] In one embodiment, the covered stations further include the incubation position 422 and the measurement position 423. In one embodiment, the covered stations further include the incubation position 422 or the measurement position 423.

[0196] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope recorded in this specification.

[0197] The above-described embodiments merely represent several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation on the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the present invention patent shall be subject to the appended claims.

Claims

1. An analysis device, characterized in that: include: A sample supply device (200), used for providing a sample to the reactor; A transfer device (500) is used to carry and transport the reactor that needs to discharge reagents; A reagent supply device (100) for supplying reagents to the reactor in the transfer device (500); A reaction device (400) for reacting a reactor containing reagents and samples; and A transfer device (600) for transferring the reactor between the transfer device (500) and the reaction device (400); wherein the transfer device (500) is independently arranged outside the reaction device (400), and the rotation center of the transfer device (500) is arranged outside the reaction device (400); The transfer device (500) comprises a rotatable transfer disk (520), the outer circumference of which is provided with a plurality of temporary storage positions (530) for temporarily storing reactors and which are distributed at intervals in the circumferential direction. The analysis device further comprises a mixing unit (800), which is provided below the transfer disk (520). The rotation of the transfer disk (520) enables the reactors in the temporary storage positions (530) to correspond to the mixing units (800) in sequence. In the clockwise direction, the middle turntable (520) has positions a, b, c and d arranged in sequence. The reactor enters and exits the middle turntable (520) at position a. The transfer trajectory of the transfer device (600) passes through position a, and the center of the middle turntable (520) and position c are on the same side of the transfer trajectory of the transfer device (600).

2. The analysis device according to claim 1, characterized in that The reaction device (400) comprises a rotatable reaction disk (410), and the reaction disk (410) and the middle turntable (520) rotate independently.

3. The analysis device according to claim 2, characterized in that The diameter of the middle turntable (520) is smaller than the diameter of the reaction disk (410).

4. The analysis device according to claim 2, characterized in that In a top-view direction, the sample supply device (200), the reagent supply device (100), and the reaction device (400) are arranged in a clockwise direction on the periphery of the transfer device (500).

5. The analysis device according to claim 2, characterized in that The reaction disk (410) is provided with a cleaning and separation position (421), an incubation position (422) and a measurement position (423), and the reactor can be carried on the cleaning and separation position (421), the incubation position (422) and the measurement position (423).

6. The analysis device according to claim 5, characterized in that The reaction disk (410) is provided with a plurality of reaction positions (420) arranged in a ring shape, the innermost circle is a cleaning and separation position (421), the outermost circle is a measurement position (423), and between the cleaning and separation position (421) and the measurement position (423) is an incubation position (422), and the incubation position (422) is provided in at least one circle.

7. The analysis device according to claim 5, characterized in that The cleaning and separation position (421), the incubation position (422) and the measurement position (423) are arranged along the radial direction of the reaction disk (410).

8. The analysis device according to claim 5, characterized in that The transfer track of the transfer device (600) at least covers the cleaning and separation position (421), the incubation position (422) and the measurement position (423).

9. The analysis device according to claim 8, characterized in that The transfer track of the transfer device (600) extends along a radius of the reaction disk (410), and at least covers all reaction positions on the reaction disk (410) along the radius.

10. The analysis device according to claim 1, characterized in that At least two groups of the reagent supply devices (100) are provided, and the two groups of the reagent supply devices (100) discharge reagents alternately to the reactor on the transfer device (500).

11. The analysis device according to claim 2, characterized in that The reagent supply device (100) comprises a reagent tray and a reagent discharge unit (120), wherein the reagent tray is used to carry the reagent, and the reagent discharge unit (120) is used to absorb the reagent in the reagent tray and discharge the reagent into the reactor.

12. The analysis device according to claim 1, characterized in that It also includes a supply tray (710), on which a temporary storage tank (720) for loading a reactor is disposed. The supply tray (710) can rotate independently to drive the temporary storage tank (720) to transfer between different workstations. The sample supply device (200) is used to discharge the sample to the reactor on the supply tray (710).

13. The analysis device according to claim 12, characterized in that The transfer track of the transfer device (600) at least covers the supply tray (710), the transfer device (500) and the reaction device (400).

14. The analysis device according to claim 13, characterized in that The transfer device (500) comprises a rotatable transfer disk (520), and the center of the transfer disk (520) and the center of the supply disk (710) are respectively located on both sides of the transfer track of the transfer device (600).

15. The analysis device according to claim 12, characterized in that It also includes a dilution and transportation device (900) for temporarily storing the reactor, and the dilution and transportation device (900) is arranged between the reaction device (400) and the transfer device (500); after the reactor receives the sample provided by the sample supply device (200) at the supply plate (710), the reactor receives the diluent provided by the reagent supply device (100) at the transfer device (500), and after dilution, the reactor is transferred to the dilution and transportation device (900).

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