Systems for closed transfer of fluids

Abstract

A system for closed transfer of fluids, the system comprising a syringe adapter, the syringe adapter comprising: a housing having a first end and a second end, the first end of the housing being configured to be secured to a first container; a cannula having a first end and a second end, the second end of the cannula being positioned in the housing; and a sealing device, the sealing device being positioned within the housing and movable within the housing, the sealing device comprising a septum. The system comprises a second component having a septum and a locking mechanism. The second component is configured to be received by the syringe adapter so that the septum of the sealing device engages the septum of the second component. The locking mechanism comprises a biasing member and an engagement member positioned on the biasing member, the engagement member being configured to engage a portion of the housing of the syringe adapter when the second component is received by the syringe adapter to secure the second component to the syringe adapter.

Description

[0001] This application is a divisional application of the Chinese patent application with Chinese application number 201810041987.X, application date January 17, 2018, and name “SYSTEM FOR CLOSED TRANSFER OF FLUID”.

[0002] CROSS-REFERENCE TO RELATED APPLICATIONS

[0003] This application claims priority to U.S. Provisional Application Serial No. 62 / 447,046, filed on January 17, 2017, the entire contents of which are incorporated herein by reference. Technical Field

[0004] The present disclosure generally relates to systems for closed transfer of fluids. More specifically, the present disclosure relates to a system for providing a leak-proof seal during transfer of a fluid from a first container to a second container. Background Art

[0005] Healthcare providers who reassemble, transport, and administer hazardous drugs (e.g., cancer treatments) can put healthcare providers at risk of exposure to these drugs, and significant hazards exist in the healthcare environment. For example, nurses caring for cancer patients are at risk of exposure to chemotherapy drugs and their toxicity. Accidental exposure to chemotherapy can affect the nervous system, damage the reproductive system, and increase the risk of developing blood cancer in the future. In order to reduce the risk of healthcare providers being exposed to toxic drugs, the closed transfer of these drugs becomes important.

[0006] Some drugs must be dissolved or diluted before administration, which involves transferring a solvent from a container through a needle into a sealed vial containing the drug in powder or fluid form. If there is any pressure differential between the interior of the vial and the surrounding environment, the drug may be inadvertently released into the environment as a gas or by aerosolization during withdrawal of the needle from the vial and while the needle is inside the vial. Summary of the invention

[0007] In one aspect, a system for closed transfer of fluids includes a syringe adapter, the syringe adapter including: a housing having a first end and a second end, the first end of the housing being configured to be secured to a first container; a cannula having a first end and a second end, the second end of the cannula being located within the housing; and a sealing device located within the housing and movable within the housing, the sealing device including a septum. The system includes a second component having a septum and a locking mechanism. The second component is configured to be received by the syringe adapter so that the septum of the sealing device engages the septum of the second component. The locking mechanism includes a biasing member and an engagement member positioned on the biasing member, the engagement member being configured to engage a portion of the housing of the syringe adapter when the second component is received by the syringe adapter to secure the second component to the syringe adapter.

[0008] The biasing member of the locking mechanism may be a cantilevered arm, and the engaging member may be a protrusion extending radially outward from the second component, the protrusion being configured to engage a portion of the housing to bias the protrusion radially inwardly via the cantilevered arm during insertion of the second component into the syringe adapter. The protrusion is configured to return to a non-biased position when the second component has been fully inserted into the syringe adapter to secure the second component to the syringe adapter. The sealing device may include a collet having a first end and a second end, at least a portion of the collet being received within the housing. The collet may include a body and a locking member connected to the body, the body defining a passageway for receiving a septum of the sealing device. The collet may be movable from a first position to a second position, in which the locking member is open to receive a mating connector, in which radial outward movement of the locking member is constrained. The second component may include a collet interface surface configured to receive and engage a locking member of the collet. The locking member may be arcuate and resilient, the locking member being connected to the body via a plurality of arms. The second component may be a patient connector having a first end and a second end, the patient connector having a body defining a passageway, the second end of the patient connector being configured to be secured to a patient intravenous line.

[0009] In another aspect, a system for closed transfer of fluids includes a syringe adapter, the syringe adapter including: a housing having a first end and a second end, the first end of the housing being configured to be secured to a first container; a cannula having a first end and a second end, the second end of the cannula being located within the housing; and a sealing device located within the housing and movable within the housing, the sealing device including a septum. The system includes a second component having a septum and a connecting member, the second component being configured to be received by the syringe adapter so that the septum of the sealing device engages the septum of the second component. The connecting member is configured to engage a portion of the housing of the syringe adapter when the second component is received by the syringe adapter to secure the second component to the syringe adapter.

[0010] The connecting member may be a protrusion extending radially outward from the second component, the protrusion being received by a recessed portion of the housing of the syringe adapter when the second component is received by the syringe adapter to secure the second component to the syringe adapter. The protrusion may be hemispherical. The protrusion may be a plurality of hemispherical spaced apart protrusions. The sealing device may be a collet having a first end and a second end, at least a portion of the collet being received within the housing, the collet comprising a body and a locking member connected to the body. The body of the collet defines a passageway for receiving a diaphragm of the sealing device. The collet is movable from a first position to a second position, in which the locking member is open to receive a mating connector, in which radial outward movement of the locking member is constrained. The second component may be a collet interface surface, the collet interface surface being configured to receive and engage a locking member of the collet. The locking member may be arcuate and resilient, the locking member being connected to the body via a plurality of arms. The second component may be a patient connector having a first end and a second end, the patient connector having a body defining a passageway, the second end of the patient connector being configured to be secured to a patient intravenous line. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The above and other features and advantages of the present disclosure and the manner in which they are obtained will become more apparent, and the disclosure itself will be better understood, by referring to the following description of various aspects of the present disclosure in conjunction with the accompanying drawings, in which:

[0012] Figure 1 is a cross-sectional view of a syringe adapter according to one aspect of the present invention.

[0013] Figure 2 is a cross-sectional view of a syringe adapter according to one aspect of the present invention.

[0014] Figure 3is a perspective view of a collet according to one aspect of the present invention.

[0015] Figure 4 yes Figure 3 Cross-sectional view of a collet.

[0016] Figure 5 is a front view of a system for closed transfer of fluids according to one aspect of the present invention.

[0017] Figure 6 yes Figure 5 A cross-sectional view of the system.

[0018] Fig. 7A is a front view of a first diaphragm according to one aspect of the present invention.

[0019] Figure 7B yes Fig. 7A A cross-sectional view of the first diaphragm.

[0020] Fig. 8A is a front view of a first diaphragm according to one aspect of the present invention.

[0021] Figure 8B yes Fig. 8A A cross-sectional view of the first diaphragm.

[0022] Fig.9A is a front view of a first diaphragm according to one aspect of the present invention.

[0023] Fig. 9B yes Fig.9A A cross-sectional view of the first diaphragm.

[0024] Fig. 10A is a front view of a first diaphragm according to one aspect of the present invention.

[0025] Fig. 10B yes Fig. 10A A cross-sectional view of the first diaphragm.

[0026] Fig.11A is a front view of a first diaphragm according to one aspect of the present invention.

[0027] Fig. 11B yes Fig.11A A cross-sectional view of the first diaphragm.

[0028] Fig. 12A is a front view of a first diaphragm according to one aspect of the present invention.

[0029] Fig. 12B yes Fig. 12A A cross-sectional view of the first diaphragm.

[0030] Fig.13Ais a front view of a first diaphragm according to one aspect of the present invention.

[0031] Fig. 13B yes Fig.13A A cross-sectional view of the first diaphragm.

[0032] Fig.14A is a front view of a second diaphragm according to an aspect of the present invention.

[0033] Fig. 14B yes Fig.14A A cross-sectional view of the second diaphragm.

[0034] Fig.15A is a front view of a second diaphragm according to an aspect of the present invention.

[0035] Fig. 15B yes Fig.15A A cross-sectional view of the second diaphragm.

[0036] Fig.16A is a front view of a second diaphragm according to an aspect of the present invention.

[0037] Fig. 16B yes Fig.16A A cross-sectional view of the second diaphragm.

[0038] Fig.17A is a front view of a second diaphragm according to an aspect of the present invention.

[0039] Fig. 17B yes Fig.17A A cross-sectional view of the second diaphragm.

[0040] Fig.18A is a front view of a second diaphragm according to an aspect of the present invention.

[0041] Fig.18B yes Fig.18A A cross-sectional view of the second diaphragm.

[0042] Fig.19A is a front view of a second diaphragm according to an aspect of the present invention.

[0043] Fig.19B yes Fig.19A A cross-sectional view of the second diaphragm.

[0044] Fig. 20 is a front view of a system for closed transfer of fluids according to one aspect of the present invention.

[0045] Fig.21 yes Fig. 20 A cross-sectional view of the system shown.

[0046] Fig. 22is a cross-sectional view of a syringe adapter according to one aspect of the present invention.

[0047] Fig.23 is a cross-sectional view of a syringe adapter according to one aspect of the present invention.

[0048] Fig.24 is a front view of a syringe adapter according to one aspect of the present invention.

[0049] Fig.25 is a front view of a system for closed transfer of fluids according to one aspect of the present invention.

[0050] Fig.26 yes Fig.25 A cross-sectional view of the system.

[0051] Fig. 27 yes Fig.25 A cross-sectional view of a system showing a patient connector secured to a syringe adapter.

[0052] Fig.28 According to one aspect of the present invention Fig.25 Top view of the patient connector.

[0053] Fig.29 yes Fig.25 An enlarged cross-sectional view of the system showing the patient connector secured to the syringe adapter.

[0054] Fig.30 is a perspective view of a system for closed transfer of fluids according to one aspect of the present invention.

[0055] Fig.31 yes Fig.30 A cross-sectional view of the system.

[0056] Fig.32 yes Fig.30 A cross-sectional view of a system showing a patient connector secured to a syringe adapter with the locking mechanism in an unlocked position.

[0057] Fig.33 yes Fig.30 A perspective view of a system showing a patient connector secured to a syringe adapter with the locking mechanism in a locked position.

[0058] Fig.34 yes Fig.30 A cross-sectional view of a system showing a patient connector secured to a syringe adapter with the locking mechanism in a locked position.

[0059] Fig.35 According to one aspect of the present invention Fig.30 Exploded perspective view of the system.

[0060] Like reference numerals refer to like parts throughout the several views.The examples set out herein illustrate some exemplary aspects of the disclosure, and these examples are not to be construed as limiting the scope of the disclosure in any way. DETAILED DESCRIPTION

[0061] The following description is provided to enable those skilled in the art to realize and use the described aspects considered for implementing the present invention. However, various modifications, equivalents, variations, and alternatives will be apparent to those skilled in the art. Any and all such modifications, variations, equivalents, and alternatives all fall within the spirit and scope of the present invention.

[0062] Hereinafter, for descriptive purposes, the terms "upper", "lower", "right", "left", "vertical", "horizontal", "top", "bottom", "lateral", "longitudinal", and their derivatives shall relate to the present invention as it is oriented in the accompanying drawings. However, it should be understood that the present invention may assume various alternative variations unless expressly specified to the contrary. It should also be understood that the specific devices shown in the drawings and described in the following specification are merely exemplary aspects of the present invention. Therefore, specific dimensions and other physical characteristics related to the various aspects disclosed herein should not be considered limiting.

[0063] refer to Figure 1 , shows a syringe adapter 12 according to one aspect of the present invention. The syringe adapter 12 is a component of a system for closed transfer of fluids. In particular, the syringe adapter 12 is configured to connect a syringe (not shown) to another medical device or fluid container. The medical device may be, for example, a patient line, a vial adapter, a fluid container, or an infusion adapter. In other examples, the container may be a medical vial, a syringe barrel, an IV bag, or a similar container for receiving a fluid to be administered to a patient. The syringe adapter 12 may be used to facilitate closed transfer of fluids between a syringe and a medical device or a fluid container. The syringe adapter 12 is similar to the syringe adapter shown and described in U.S. Patent Application Publication No. 2015 / 0297454, and operates in a similar manner, the entire contents of which are incorporated herein by reference.

[0064] Reference again Figure 1, syringe adapter 12 includes a housing 16 having a first end 18 and a second end 20 and defining an interior space 22. The first end 18 of the housing 16 of the syringe adapter 12 includes a syringe attachment 24, such as a female Luer connector, defining a passage 26. Although the female Luer connector is shown as being used to connect to a corresponding male Luer connector of a syringe (not shown), other suitable connection devices may be used to connect to a syringe, a container, or any other medical device. A cannula 28 having a distal end 30 is secured to the syringe attachment 24 and is in fluid communication with the passage 26 of the syringe attachment 24. The syringe adapter 12 also includes a sealing device positioned within the housing 16 of the syringe adapter 12. The sealing device includes a cartridge 32 that receives a first septum 34. The cartridge 32 is configured to move within the interior space 22 of the housing 16 of the syringe adapter 12, as discussed in more detail below. The housing 16 of the syringe adapter 12 may include a structure that enhances the user's grip on the syringe adapter 12. Additional or alternative gripping structures and surfaces may be provided to assist a user in gripping the body of syringe adapter 12 .

[0065] Syringe adapter 12 includes a first connection interface 36 intermediate first end 18 and second end 20 of housing 16 of syringe adapter 12, first connection interface 36 including a locking member 38 received within a transverse opening 40 in housing 16 of syringe adapter 12. Locking member 38 is configured to move between a closed position and an open position. Locking member 38 also includes a cantilever spring 46 extending in the longitudinal direction of syringe adapter 12. Locking member 38 is configured to engage a cam surface extending radially outward from housing 16 of syringe adapter 12. In particular, locking member 38 is configured to be disposed in a closed position in which a portion of locking member 38 adjacent to a central opening of locking member 38 is located within interior space 22 of syringe adapter 12 when no external force is applied to locking member 38. When locking member 38 is moved to the open position, cantilever spring 46 engages the cam surface to generate a biasing force that pushes locking member 38 back to the closed position, in which the central opening of locking member 38 is aligned with interior space 22 of syringe adapter 12 or does not interfere with or obstruct an object to be inserted into interior space 22. Thus, when locking member 38 is moved to the open position, locking member 38 will be pushed back to the closed position when the external force acting on locking member 38 is released. Although locking member 38 is shown as having a cantilever spring 46, any other suitable biasing member may be provided, including but not limited to a compression spring, an extension spring, an elastomeric material, etc.

[0066] Reference Figures 1 to 3, the collet 32 ​​includes a body 52 having a first end 54 and a second end 56. The body 52 defines a passage 58 extending through the body 52. ​​The body 52 is generally cylindrical, but collets of other suitable shapes may be used. The collet 32 ​​also includes a locking member 60 connected to the body 52 of the collet 32. The collet 32 ​​can move from a first position to a second position, in which the locking member 60 is opened to receive a mating connector (e.g., a patient connector), in which the radially outward movement of the locking member 60 is restricted. The locking member 60 is connected to the body 52 via a plurality of arms 62. Since the locking member 60 is connected to the body 52 via the plurality of arms 62, the locking member 60 is arcuate and resilient. More specifically, the plurality of arms 62 are flexible and allow the locking member 60 to expand radially outward or radially inward. In one aspect, locking member 60 is configured to expand radially outward when a mating connector (e.g., a patient connector) is inserted into locking member 60, and then move radially inward as collet 32 ​​transitions from the first position to the second position. Alternatively, locking member 60 may not move radially inward or outward when a mating connector is inserted into locking member 60, and may then move radially inward as collet 32 ​​transitions from the first position to the second position. Second end 20 of housing 16 of syringe adapter 12 defines an annular recess 64 adjacent interior space 22 that receives locking member 60 when collet 32 ​​is in the first position. Annular recess 64 of housing 16 provides space for locking member 60 to expand radially outward. When collet 32 ​​transitions from the first position to the second position, collet 32 ​​moves axially toward first end 18 of syringe adapter 12, and locking member 60 is biased radially inward due to engagement of locking member 60 with housing 16 of syringe adapter 12.

[0067] like Figure 3 As shown, the locking member 60 of the collet 32 ​​defines a pair of openings 66 extending in a direction perpendicular to the longitudinal axis of the collet 32. The openings 66 divide the locking member 60 into two arcuate portions, each of which is connected to the body 52 of the collet 32 ​​by two arms 62. However, other suitable arrangements and shapes for the collet 32 ​​and the locking member 60 may be used. The locking member 60 of the collet 32 ​​protrudes radially inwardly and radially outwardly relative to the plurality of arms 62.

[0068] Refer again Figure 1 and Figure 3, body 52 of collet 32 ​​includes second connection interface 70 that is configured to mate with and lock with first connection interface 36 of syringe adapter 12. Second connection interface 70 is defined by body 52 of collet 32. First end 54 of collet 32 ​​is configured to be received within interior space 22 of syringe adapter 12 when locking member 38 of first connection interface 36 is in an open position, and is restricted from moving within interior space 22 of syringe adapter 12 when locking member 38 is in a closed position. When second connection interface 70 is fully mated to first connection interface 36, locking member 38 of first connection interface 36 is configured to be in a closed position to lock longitudinal and lateral movement of first connection interface 36 relative to second connection interface 70, but still allow rotational movement of first connection interface 36 relative to second connection interface 70.

[0069] refer to Figure 1 The passage 58 of the body 52 of the collet 32 ​​includes a first counterbore 68 , a second counterbore 74 positioned opposite the first counterbore 68 , and an intermediate portion 76 located between the first counterbore 68 and the second counterbore 74 .

[0070] refer to Figure 3 The body of the collet 32 ​​also includes a plurality of ribs 78 located intermediate the first end 54 and the second end 56. The ribs 78 extend longitudinally, although other suitable configurations may be employed. A plurality of recesses 80 are located between adjacent ribs 78.

[0071] refer to Figures 2 to 6 In one aspect of the invention, the passage 58 of the body of the collet 32 ​​includes a narrowed portion 79 configured to compress a portion of the first diaphragm 34. In one aspect, the intermediate portion 76 of the passage 58 of the body 52 of the collet 32 ​​includes the narrowed portion 79. The narrowed portion 79 of the passage 58 has a smaller diameter than the remainder of the intermediate portion 76 of the passage 58.

[0072] Reference Figure 2 and Figure 6, the first diaphragm 34 includes a body 82 having a first end 84 and a second end 86. The first end 84 and the second end 86 of the body 82 of the first diaphragm 34 include a first head portion 88 and a second head portion 90, respectively. The body 82 of the first diaphragm 34 defines a passage 92 extending from the first end 84 of the body 82 toward the second end 86. The passage 92 terminates at a location between the first end 84 and the second end 86 of the body 82. The body 82 of the first diaphragm 34 also defines an annular recess 87 located between the first end 84 and the second end 86. The body 82 of the first diaphragm 34 is received by and secured to the passage 58 of the collet 32. The first head portion 88 of the first diaphragm 34 engages with the first counterbore 68 of the collet 32. The second head portion 90 extends beyond the passage 58 of the body 52 of the collet 32, wherein the second head portion 90 engages with the body 52 of the collet 32. The annular recess 87 of the first member 34 is received by the intermediate portion 76 of the collet 32 ​​, wherein the narrowed portion 79 engages and compresses the annular recess 87 of the first member 34 .

[0073] The second head portion 90 defines a convex surface, but other suitable septum arrangements may be provided, as discussed in more detail below. When the collet 32 ​​is in the first position, the cannula 28 is received within the passage 92 of the first septum 34, wherein the distal end 30 of the cannula 28 is positioned within the passage 92. When the collet 32 ​​is transitioned from the first position to the second position, the distal end 30 of the cannula 28 is configured to pierce the first septum 34 and extend through the first septum 34. The first septum 34 is configured to engage and seal against the intermediate portion of the cannula 28 during use of the syringe adapter 12 to maintain a sealed and leak-free connection with a mating component.

[0074] After first septum 34 is engaged with a corresponding septum (e.g., second septum 94 from a patient connector 96, a vial adapter, or an IV bag lancet) during use, collet 32 ​​is configured to move toward first end 18 of syringe adapter 12 and transition from a first position to a second position such that distal end 30 of cannula 28 pierces first septum 34 to place syringe adapter 12 in fluid communication with a corresponding device secured to syringe adapter 12. When collet 32 ​​is returned to the first position, first septum 34 may be disengaged from a corresponding septum, thereby positioning distal end 30 of cannula 28 within passages 58, 92 of collet 32 ​​and first septum 34. Such an arrangement shields distal end 30 of cannula 28 from accidental needle sticks and also prevents any fluid leakage during fluid delivery when syringe adapter 12 is in use.

[0075] Reference Figure 5 and Figure 6, the patient connector 96 includes a body 102 having a first end 104 and a second end 106 and defining a passage 108 therethrough. The first end 104 of the patient connector 96 also includes a cartridge interface 110. The cartridge interface 110 is defined by a portion of the body 102 of the patient connector 96 that is recessed relative to the first end 104 of the body 102 of the patient connector 96. The first end 104 of the body 102 of the patient connector 96 also includes a septum seat 112 that receives the second septum 94. As discussed above in conjunction with the syringe adapter 12, the second septum 94 of the patient connector 96 is configured to engage the first septum 34 of the syringe adapter 12 and provide a substantially leak-free connection with the syringe adapter 12 during fluid transfer. The second end 106 of the patient connector 96 includes an intravenous (IV) line attachment, such as a male Luer connector, although any other suitable connection device may be used.

[0076] Reference Figure 2 and Figure 6 As described above, the narrowed portion 79 of the passageway of the body 52 of the collet 32 ​​compresses the first diaphragm 34. In particular, the narrowed portion 79 compresses the annular recessed portion 89 of the first diaphragm 34. During use of the syringe adapter 10, back pressure acting on the first diaphragm 34 may potentially cause the first diaphragm 34 to disengage from the collet 32. The narrowed portion 79 acts as an anti-back pressure feature by applying additional compression between the collet 32 ​​and the first diaphragm 34.

[0077] Reference Figure 7A-13B , other aspects of the first diaphragm 34 are shown. In particular, various shapes, configurations, and cavities may be used for the first diaphragm 34. Figure 7A-13B The geometry shown in the figure can be pushed or pulled into a mating component and retained without the need for a secondary assembly process or a multi-piece housing. The passage 92 of the first diaphragm can include a variety of shapes, lengths, widths, and configurations. Moreover, as shown in FIGS. 12-13B , the first end 84 of the first diaphragm 34 may not include a head portion or radial protrusion.

[0078] Reference Figures 14A-19B , other aspects of the second diaphragm 94 are shown. In particular, various shapes and configurations may be used for the second diaphragm 94. Fig.17A and 17B As shown, the second diaphragm 94 may include an annular recess 98 .

[0079] Reference Figure 21-24 , shows a syringe adapter 120 and a patient connector 122 according to another aspect of the present invention. The syringe adapter 120 is similar to Figure 1 The syringe adapter 12 shown here and operates in a similar manner. However, Figure 21-24The syringe adapter 120 and patient connector 122 of the present invention include different connection arrangements. In particular, instead of providing the first connection interface 36 and the second connection interface 70, the patient connector 122 includes a locking mechanism 124 having a biasing member 126 and an engagement member 128 positioned on the biasing member 126. The engagement member 128 is configured to engage a portion of the housing 16 of the syringe adapter 120 when the patient connector 122 is received by the syringe adapter 120 to secure the patient connector 122 to the syringe adapter 120. Although the locking mechanism 124 is shown as being connected to the patient connector 122, the locking mechanism 124 can be provided on any suitable component of a system for closed transfer of fluids, including but not limited to a vial adapter, an infusion adapter, etc.

[0080] Biasing member 126 of locking mechanism 124 is a cantilevered arm, but other suitable biasing means may also be used. Engagement member 128 is a protrusion extending radially outward from patient connector 122, but other suitable protrusions may also be used. Engagement member 128 is configured to engage a portion of housing 16 of syringe adapter 120 to bias engagement member 128 radially inwardly via the cantilevered arm during insertion of patient connector 122 into syringe adapter 120. Engagement member 128 is also configured to return to a non-biased position when patient connector 122 has been fully inserted into syringe adapter 120 to secure patient connector 122 to syringe adapter 120. Thus, after patient connector 122 is inserted into housing 16 of syringe adapter 120, biasing member 126 is radially inwardly deflected by engagement of engagement member 128 with housing 16 of syringe adapter 120. Once fully inserted, biasing member 126 returns to the non-biased position, wherein engagement member 128 retains patient connector 122 in syringe adapter 120 and collet 32 ​​engages with collet interface 110 of patient connector 122. To remove patient connector 122, the user applies an axial force to patient connector 122 in a direction away from syringe adapter 120, causing biasing member 126 to be deflected radially inwardly again by engagement of engagement member 128 with housing 16 of syringe adapter 120 until engagement member 128 is axially displaced beyond housing 16 of syringe adapter 120. Collet 32 ​​will also be released from patient connector 122 in the same manner as discussed above with respect to syringe adapter 12.

[0081] Reference Fig.21 and Fig.23, syringe adapter 120 may further include a collet drive member 132 configured to bias collet 32 ​​toward second end 20 of syringe adapter 120 to retain collet 32 ​​in the first position. Syringe adapter 120 operates in the same manner as discussed above with respect to syringe adapter 12, but collet drive member 132 requires a user to overcome the biasing force of collet drive member 132 to move collet 32 ​​from the first position to the second position when syringe adapter 120 is mated with a mating connector, such as patient connector 122. Collet drive member 132 may be a spring, although other suitable biasing means may be used. Furthermore, as described above, collet drive member 132 may be a spring, although other suitable biasing means may be used. Figure 21-23 As shown, the collet 32 ​​may not include the first counterbore 68 , with the first end 54 of the collet defining a planar surface 134 .

[0082] Reference Figure 25-29 , shows a syringe adapter 150 and a patient connector 152 according to another aspect of the present invention. The syringe adapter 150 is similar to Figure 1 The syringe adapter 12 shown in FIG. 1 and operates in a similar manner. However, Figure 25-29 The syringe adapter 150 and patient connector 152 of the present invention include different connection arrangements. In particular, instead of providing the first connection interface 36 and the second connection interface 70, the patient connector 152 includes a connection member 154. The connection member 154 is configured to engage a portion of the housing 16 of the syringe adapter 150 when the patient connector 152 is received by the syringe adapter 150 to secure the patient connector 152 to the syringe adapter 150. Although the connection member 154 is shown with the patient connector 152, the connection member 154 can be provided on any suitable component of the system for closed transfer of fluids, including but not limited to a vial adapter, an infusion adapter, etc.

[0083] Connecting member 154 is a protrusion extending radially outward from patient connector 152. Connecting member 154 is received by recessed portion 156 of housing 16 of syringe adapter 150 when patient connector 152 is received by syringe adapter 150 to secure patient connector 152 to syringe adapter 150. Connecting member 154 is hemispherical, but other suitable shapes and configurations may also be used. Fig.28 As shown, three equally spaced connection members 154 are provided on patient connector 152, although one or more connection members 154 may be provided. When patient connector 152 is inserted into housing 16 of syringe adapter 150, second septum 94 of patient connector 152 engages first septum 34 of collet 32 ​​and moves collet 32 ​​to the second position, as described above with respect to syringe adapter 12. However, as Fig. 27 and 29As shown, when collet 32 ​​is transitioned to the second position, the one or more connecting members 154 engage housing 16 of syringe adapter 150 and are received within recessed portion 156 of housing 16 to further secure patient connector 152 to syringe adapter 150. To remove patient connector 152, the user applies an axial force to patient connector 152 in a direction away from syringe adapter 150 such that the one or more connecting members 154 are freed from recessed portion 156 of housing 16 of syringe adapter 150. Collet 32 ​​will also be released from patient connector 152 in the same manner as discussed above.

[0084] refer to Figure 30-35 , shows a syringe adapter 170 and a patient connector 172 according to another aspect of the present invention. The syringe adapter 170 is similar to Figure 1 The syringe adapter 12 shown in FIG. 1 and operates in a similar manner. However, Figure 25-29 The syringe adapter 170 includes a different connection arrangement. The syringe adapter 170 includes a Fig.31 and 32 ) and locked position (shown in Fig.33 and 34 1 and 1 . The collet 32 ​​includes a locking mechanism 174 that moves between the locked and unlocked positions. The collet 32 ​​includes a locking interface 176 that is configured to engage the locking mechanism 174 when the collet 32 ​​is in the second position and when the locking mechanism 174 is in the locked position. The locking mechanism 174 is disengaged from the locking interface 176 when the collet 32 ​​is in the second position and when the locking mechanism 174 is in the unlocked position. The locking mechanism 174 can be manually moved between the locked position and the unlocked position by a user, although other suitable arrangements can also be used.

[0085] The locking mechanism 174 has a first end 178 and a second end 180 and defines an opening 182 that is configured to receive the collet 32. When the locking mechanism 174 is in the unlocked position, the first end 178 of the locking mechanism 174 protrudes from the housing 16 and the second end 180 of the locking mechanism 174 is received within the housing 16. When the locking mechanism 174 is in the locked position, the first end 178 of the locking mechanism 174 is received within the housing 16 and the second end 180 of the locking mechanism 174 protrudes from the housing 16. The second end 180 of the locking mechanism includes an indicator 184. The indicator 184 can be a colored portion of the locking mechanism 174 that is different from other portions of the locking mechanism 174. The colored portion can be a primary color, such as red. Locking mechanism 174 is received within lateral opening 40 of housing 16 of syringe adapter 170 and retained within housing 16 via a retaining portion 186 of locking mechanism 174 positioned intermediate first end 178 and second end 180 of locking mechanism 174 that engages housing 16 .

[0086] like Fig.32 As shown, when patient connector 172 is received within syringe adapter 170 and collet 32 ​​is moved to the second position, collet 32 ​​is received by opening 182 of locking mechanism 174. To maintain collet 32 ​​and patient connector 172 in the second position, locking mechanism 174 is transitioned to the locked position such that locking mechanism 174 engages locking interface 176 of collet 32, and indicator 184 provides an indication of the locked state of syringe adapter 170.

[0087] Although the present disclosure has been described as having an exemplary design, the present disclosure can be further modified within the spirit and scope of the present disclosure. Therefore, the present application is intended to cover any variation, use, or adaptive modification of the use of its basic principle of the present disclosure. In addition, the present application is intended to cover the following deviations related to the present disclosure, which are known or generally practiced in the field to which the present disclosure belongs, and which fall within the scope of the appended claims.

Claims

1. A system for closed transfer of a fluid, the system comprising: A syringe adapter, the syringe adapter comprising: a housing having a first end and a second end, the first end of the housing being configured to be secured to a first container; a sleeve having a first end and a second end, the second end of the sleeve being positioned within the housing; a sealing device located within the housing and movable within the housing, the sealing device comprising a diaphragm; and a second component including a septum and an engagement member having a plurality of projections, the second component being configured to be received by the syringe adapter such that the septum of the sealing device engages the septum of the second component, the plurality of projections of the engagement member being configured to engage a portion of a housing of the syringe adapter when the second component is received by the syringe adapter to secure the second component to the syringe adapter.

2. The system according to claim 1, wherein: The plurality of protrusions extend radially outward from the second member.

3. The system according to claim 1, wherein: The sealing device includes a collet having a first end and a second end, at least a portion of the collet being received within the housing, the collet including a body and a locking member connected to the body, the body defining a passageway for receiving a septum of the sealing device, the collet being movable from a first position in which the locking member is open to receive a mating connector to a second position in which the locking member is restrained from radially outward movement.

4. The system according to claim 3, wherein: The plurality of protrusions extend radially outward from the second member.

5. The system according to claim 4, wherein: The second component includes a collet interface surface configured to receive and engage a locking member of the collet.

6. The system according to claim 1, wherein: The second component includes a patient connector having a first end and a second end, the patient connector having a body defining a passageway, the second end of the patient connector being configured to be secured to a patient intravenous line.

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