An infrared composite deep electrode and monitoring system

Abstract

The embodiment of the present application provides an infrared composite deep electrode and monitoring system, which includes: a deep electrode for implantation in human tissue, including a tube body, an electrode wire partially disposed in the tube body, and an electrode point disposed on the tube body and connected to the electrode wire; an infrared probe disposed on the deep electrode, an infrared connecting wire partially disposed in the tube body, and the infrared probe is connected to the infrared connecting wire; wherein the infrared probe includes a near-infrared probe and / or a mid-infrared probe, and the tube body and / or the electrode point are configured not to block the infrared light emitted by the infrared probe. The present application can obtain information on the spatial and temporal activity changes of neural units in the brain through EEG signals and near-infrared imaging data, and assist researchers in predicting the required thermal coagulation time and monitoring the degree of thermal coagulation through infrared imaging data, and can also regulate the electrical activity of brain neuron cells.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of medical device technology, and in particular to an infrared composite deep electrode and a monitoring system. Background Art

[0002] At present, the infrared probes of infrared imaging products are only distributed on the surface of the scalp. The collected signals are the synchronous sum of the postsynaptic potentials of a large number of nerve tissues. However, due to the complexity of human tissues and the thickness of the scalp varies from person to person, the data obtained needs to be corrected by software, and there is inevitably a certain deviation. Infrared light can penetrate the scalp and skull to enter the cerebral cortex area 2-3cm deep under the scalp. The depth of signal collection is limited, and the electrical activity of a single neuron is very small and cannot be recorded on the scalp. In addition, it does not have the function of regulating nerve cell activity. Summary of the invention

[0003] In order to solve the technical problems in the above-mentioned background technology, the present application provides an infrared composite deep electrode.

[0004] In the first aspect of the present application, an infrared composite deep electrode is provided, comprising: a deep electrode for implantation in human tissue, comprising a tube body, an electrode wire partially disposed in the tube body, and an electrode point disposed on the tube body and connected to the electrode wire; an infrared probe disposed on the deep electrode, an infrared connecting wire partially disposed inside the tube body, the infrared probe being connected to the infrared connecting wire; wherein the infrared probe comprises a near-infrared probe and / or a mid-infrared probe, and the tube body and / or the electrode point are configured so as not to block the infrared light emitted by the infrared probe.

[0005] It can be seen from the above technical scheme that the deep electrode includes a tube body, an electrode wire partially arranged in the tube body, and an electrode point arranged on the tube body and connected to the electrode wire, which can be implanted into human tissue through surgery. A near-infrared probe is arranged on the deep electrode, which can image the inside of the human tissue when the deep electrode is implanted into the human tissue (for example, in the cranial cavity). A mid-infrared probe is arranged on the deep electrode, which can regulate the electrical activity of neuronal cells when the deep electrode is implanted into the human tissue. The length of the deep electrode can also be selected according to the depth to be detected, thereby avoiding the detection depth limitation of the infrared signal and improving the signal sensitivity and spatial resolution. At the same time, when the infrared composite deep electrode is implanted into the human tissue, it only needs to bear the same trauma as the original deep electrode, which improves the safety of the operation.

[0006] In a possible implementation, the infrared probes are distributed on the deep electrode in a single row or in multiple rows along the extension direction of the deep electrode.

[0007] In a possible implementation, the electrode point includes an annular electrode point, and the annular electrode point is sleeved on the outer surface of the tube body.

[0008] In a possible implementation, the electrode point further includes a plugging electrode point, and the plugging electrode point is arranged at an end of one end of the tube body.

[0009] In a possible implementation, a sealing plug is provided at the end of the other end of the tube body, and the electrode wire and the infrared connection wire pass through the sealing plug.

[0010] In a possible implementation, the diameter of the tube is 0.5 to 3 mm, and the diameter of the annular electrode point is 0.5 to 3 mm; when the number of the electrode points is greater than or equal to two, the distance between two adjacent electrode points is 2 to 10 mm.

[0011] In a possible implementation, the tube body is made of one of polyurethane materials, silicone materials or polyimide materials; and / or the electrode points and the electrode wires are made of one of platinum-iridium alloy, stainless steel or nickel-chromium alloy; and / or the infrared probe is an avalanche diode or a photodiode.

[0012] In a possible implementation, an electrode wire sleeve is provided at the end of the electrode wire located outside the tube body, and an infrared connection wire sleeve is provided at the end of the infrared connection wire located outside the tube body.

[0013] In a second aspect of the present application, a monitoring system is provided, which includes the above-mentioned infrared composite deep electrode and also includes a multimodal brain-computer interface subsystem, wherein the multimodal brain-computer interface subsystem is connected to the electrode wires and / or infrared connecting wires in the infrared composite deep electrode.

[0014] It can be seen from the above technical scheme that by connecting the electrode wires and / or infrared connecting wires in the infrared composite deep electrode to the multimodal brain-computer interface subsystem, it is possible to obtain multimodal brain imaging information while the deep electrode collects deep EEG signals and local thermocoagulation in the brain, thereby forming multimodal brain function information data, which has important guiding significance in clinical research.

[0015] It should be understood that the contents described in the Summary of the Invention are not intended to limit the key or important features of the embodiments of the present application, nor are they intended to limit the scope of the present application. Other features of the present application will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The above and other features, advantages and aspects of the embodiments of the present application will become more apparent with reference to the following detailed description in conjunction with the accompanying drawings. In the accompanying drawings, the same or similar reference numerals represent the same or similar elements, wherein:

[0017] Figure 1 A schematic structural diagram of an infrared composite deep electrode according to an embodiment of the present application is shown.

[0018] Figure 2 A schematic structural diagram of an infrared composite deep electrode according to another embodiment of the present application is shown.

[0019] Figure 3a A schematic diagram showing an installation method of an infrared probe according to an embodiment of the present application is shown.

[0020] Figure 3b A schematic diagram showing another installation method of an infrared probe according to an embodiment of the present application is shown.

[0021] Figure 3c A schematic diagram showing another installation method of the infrared probe according to an embodiment of the present application is shown.

[0022] Figure 3d A schematic diagram showing another installation method of the infrared probe according to an embodiment of the present application is shown.

[0023] Figure 3e A schematic diagram showing another installation method of the infrared probe according to an embodiment of the present application is shown.

[0024] Figure 4 A schematic structural diagram of a monitoring system according to an embodiment of the present application is shown.

[0025] in,

[0026] 100, deep electrode; 110, tube body; 120, electrode wire; 130, electrode point; 131, ring electrode point; 132, plug electrode point; 140, electrode wire sleeve;

[0027] 210, infrared probe; 220, infrared connecting line; 230, infrared connecting line casing;

[0028] 300. Multimodal brain-computer interface subsystem. DETAILED DESCRIPTION

[0029] Before describing the various embodiments of the present application, the technical terms involved below are first explained.

[0030] Near-infrared spectroscopy (NIRS) is a newly emerged non-invasive optical imaging technology that uses the changes in the content of oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb) in the local cortex during brain activity to obtain information about brain function. Oxygenated hemoglobin and deoxygenated hemoglobin have very little absorption of the near-infrared band (650-950nm). This characteristic allows near-infrared light to penetrate the scalp and skull and enter the cerebral cortex area 2-3cm deep under the scalp. When the activity of a local area of ​​the cerebral cortex increases, blood flow increases, causing an increase in the content of oxygenated hemoglobin and a decrease in the content of deoxygenated hemoglobin. Oxygenated hemoglobin and deoxygenated hemoglobin have different spectral absorption characteristics. By using two or more different wavelengths of near-infrared light to be incident from a certain point on the cerebral scalp and detecting the changes in the outgoing light from a position several centimeters away from the incident point (2 to 5 cm is internationally recognized as the optimal distance), the changes in the content of oxygenated hemoglobin and deoxygenated hemoglobin can be inversely calculated, thereby obtaining the characteristics of brain function activation.

[0031] At present, the infrared probes of infrared imaging products are only distributed on the surface of the scalp. The collected signals are the synchronous sum of the postsynaptic potentials of a large number of nerve tissues. However, due to the complexity of human tissues and the thickness of the scalp varies from person to person, the data obtained needs to be corrected by software, and there is inevitably a certain deviation. In addition, infrared light can penetrate the scalp and skull to enter the cerebral cortex area 2-3cm deep under the scalp, which limits the depth of signal collection. In addition, the electrical activity of a single neuron is very small and cannot be recorded on the scalp.

[0032] In order to solve the above problems, an embodiment of the present application provides an infrared composite deep electrode.

[0033] The detection device provided in the embodiments of the present application can be applied to the monitoring of the brain, the monitoring of the spinal cord and the monitoring of other tissues in the body. When monitoring the brain, it can be achieved by monitoring the EEG signals; when monitoring the spinal cord, it can be achieved by monitoring the spinal cord electrical signals; when monitoring other tissues in the body, it can be achieved by monitoring the electrical signals.

[0034] See also Figure 1 and Figure 2 The infrared composite deep electrode comprises a deep electrode 100 for implantation in the skull, an infrared probe 210 disposed on the deep electrode 100, and an infrared connection line 220 partially disposed inside the tube body, and the infrared probe 210 is connected to the infrared connection line 220. The deep electrode 100 comprises a tube body 110, an electrode line 120 partially disposed inside the tube body 110, and an electrode point 130 disposed on the tube body 110 and connected to the electrode line 120. The tube body 110 and / or the electrode point 130 are configured not to block the infrared light emitted by the infrared probe 210.

[0035] When monitoring the human brain, the tube body 110 of the deep electrode 100 can be surgically implanted into the skull. For example, it is usually implanted in an operating room under general anesthesia through a skull burr hole or during an intracranial brain surgery. The skull burr hole implantation can use a stereotactic frame or a frameless stereotactic technique. Of course, when the deep electrode 100 is implanted into other tissues of the human body, a semi-rigid stylet or pusher can be placed in the hollow part of the tube body 110, and the tube body 110 can be inserted therewith. After the tube body 110 is inserted, the stylet or pusher is removed, and the tube body 110 is left in the human tissue.

[0036] After the deep electrode 100 is implanted in the skull, the EEG signal can be detected through the electrode point 130 on the deep electrode 100, and the infrared probe 210 on the deep electrode 100 can be used to image the skull using infrared spectroscopy technology, so as to study the infrared imaging data corresponding to the changed area according to the change of the EEG signal, so as to obtain the activity change information of the neural units in the brain in space and time. When the lesion is overheated, the EEG signal and infrared imaging data can help researchers predict the time required for heat coagulation and monitor the degree of heat coagulation through infrared imaging data.

[0037] In the embodiment of the present application, the deep electrode 100 is implanted into human tissue by surgery. By setting an infrared probe 210 on the deep electrode 100, the inside of the human tissue can be imaged when the deep electrode 100 is implanted into the human tissue (for example, in the cranial cavity). At the same time, the electrode point 130 on the deep electrode 100 is used to monitor the EEG signal. The length of the deep electrode 100 can also be selected according to the depth to be detected, thereby avoiding the detection depth limitation of the infrared signal and improving the signal sensitivity and spatial resolution. In addition, when the infrared composite deep electrode is implanted into the human tissue, it only needs to bear the same trauma as the original deep electrode 100, which improves the safety of the operation.

[0038] After the deep electrode 100 is implanted in the skull, it is also necessary to ensure the imaging effect of the infrared probe 210, that is, the tube body 110 and / or the electrode point 130 do not block the infrared light emitted by the infrared probe 210. This will be described in detail below in conjunction with specific embodiments.

[0039] First of all, it should be noted that the infrared probe 210 includes a near-infrared probe and / or a mid-infrared probe. Both near-infrared light and mid-infrared light in infrared light can directly act on nerve tissue, thereby activating or inhibiting the release of action potentials on neurons, thereby regulating brain function. The mechanism of action of near-infrared neural stimulation is generally believed to be photothermal effect, that is, infrared light is absorbed by water and generates heat, and the sudden change in temperature generates transmembrane capacitance current on the cell or activates thermosensitive ion channels, thereby affecting the electrical activity of nerve cells. The photothermal effect of mid-infrared light is weaker than that of near-infrared light, and it is difficult to regulate nerve cell activity by photothermal effect. The principle of regulating nerve cell activity by mid-infrared light is that the generation of action potentials depends on the activity of ion channel proteins on the cell membrane (including channel opening, closing, ion screening and permeability, etc.), especially voltage-gated sodium channels and potassium channels, and the vibration frequency of chemical bonds inside these biomacromolecules is in the mid-infrared range. The function of regulating channels can be achieved by forming resonance with the key chemical bonds of ion channels through mid-infrared light of a specific frequency, thereby affecting the electrical activity of neurons.

[0040] See also Figure 1 and Figure 2 The electrode point 130 includes an annular electrode point 131 and / or a plugging electrode point 132. The plugging electrode point 132 is arranged at the end of one end of the tube body 110, and the annular electrode point 131 is sleeved on the outer surface of the tube body 110. It should be noted that, in the case where there is only one electrode point 130, the electrode point 130 may include only one plugging electrode point 132 or one annular electrode point 131. When only one plugging electrode point 132 is included, the plugging electrode point 132 needs to be arranged at the end of one end of the tube body 110 to block the tube body 110. When only one annular electrode point 131 is included, a plugging electrode point needs to be arranged at the end of one end of the tube body 110.

[0041] For example, the diameter of the tube body 110 may be 0.5-3 mm, and the diameter of the annular electrode point 131 may be 0.5-3 mm. When the number of the electrode points 130 is greater than or equal to two, the interval between two adjacent electrode points 130 is 2-10 mm.

[0042] The infrared probes 210 may be arranged in a single row or in multiple rows along the extension direction of the deep electrode 100. Figure 1 and Figure 2 Only one row of infrared probes 210 is shown exemplarily, and the number of rows of infrared probes 210 can be set as needed.

[0043] In order to prevent the tube body 100 from blocking the infrared light emitted by the infrared probe 210. In a possible implementation, see Figure 1 and Figure 3a , the infrared probe 210 can be disposed on the outer surface of the tube body 110. In another possible implementation, see Figure 1 and Figure 3b The infrared probe 210 can be embedded in the wall of the tube body 110 so that the side of the infrared probe 210 that emits infrared light is exposed.

[0044] In the above two implementations, there is no requirement on the material of the tube body 110. The tube body 110 can be made of a transparent material or a non-transparent material. Figure 1 and Figure 3c The infrared probe 210 may also be disposed on the inner wall of the tube body 110 .

[0045] In this embodiment, the number of electrode points 130 and infrared probes 210 in the same row is the same, and they are staggered along the extension direction of the deep electrode on the outer surface of the tube body 110. In addition, the distance between each infrared probe 210 and the adjacent electrode point 130 in the same row is equal.

[0046] In order to make the electrode point 130 not block the infrared light emitted by the infrared probe 210. In a possible implementation, see Figure 2 and Figure 3d , the infrared probe 210 can be arranged on the outer surface of the electrode point 130. In another possible implementation, see Figure 2 and Figure 3e The infrared probe 210 can be embedded in the side wall of the electrode point 130 so that the infrared probe 210 emitting infrared light is exposed.

[0047] Since the electrode wire 120 and the infrared connection wire 130 are arranged in the tube body 110, a sealing plug can be arranged at the other end of the tube body 110 to fix the electrode wire 120 and the infrared connection wire 220, so that the electrode wire 120 and the infrared connection wire 220 pass through the sealing plug. An electrode wire sleeve 140 is arranged at the end of the electrode wire 120 located outside the tube body 110, and an infrared connection wire sleeve 230 is arranged at the end of the infrared connection wire 220 located outside the tube body 110. The electrode wire sleeve 140 and the infrared connection wire sleeve 230 can facilitate the connection of the electrode wire 120 and the infrared connection wire 220 to an external imaging device.

[0048] In the embodiment of the present application, the tube body 110 can be made of one of polyurethane materials, silicone materials or polyimide materials; the electrode points 120 and the electrode wires 130 can both be made of one of platinum-iridium alloy, stainless steel or nickel-chromium alloy; the infrared probe 210 can be an avalanche diode or a photodiode.

[0049] On the other hand, see Figure 4The embodiment of the present application also provides a monitoring system, which includes the above-mentioned infrared composite deep electrode and a multimodal brain-computer interface subsystem 300, and the multimodal brain-computer interface subsystem 300 is connected to the electrode wire 120 and / or the infrared connection wire 220 in the infrared composite deep electrode. Further, the multimodal brain-computer interface subsystem 300 can also be connected to the electrode wire sleeve 140 and / or the infrared connection wire sleeve 230 in the infrared composite deep electrode.

[0050] When in use, the interface of the electrode wire sleeve 140 and the interface of the infrared connection wire sleeve 230 are connected to the multimodal brain-computer interface subsystem 300 at the same time, or the interface of the electrode wire sleeve 140 can be connected to the multimodal brain-computer interface subsystem 300 alone, and the interface of the infrared connection wire sleeve 230 can be connected to the multimodal brain-computer interface subsystem 300 alone for use.

[0051] The multimodal brain-computer interface subsystem 300 can monitor EEG signals and infrared imaging information in real time. Users can monitor EEG signals and near-infrared imaging data through the human-computer exchange interface of the multimodal brain-computer interface subsystem 300, and perform related operations such as thermocoagulation when necessary.

[0052] In the embodiment of the present application, by connecting the electrode wires and / or infrared connecting wires in the infrared composite deep electrode to the multimodal brain-computer interface subsystem, it is possible to obtain multimodal brain imaging information while the deep electrode collects deep EEG signals and local thermocoagulation in the brain, thereby forming multimodal brain function information data, which has important guiding significance in clinical research.

[0053] The above description is only a preferred embodiment of the present application and an explanation of the technical principles used. Those skilled in the art should understand that the scope of application involved in the present application is not limited to the technical solution formed by a specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the aforementioned application concept. For example, the above features are replaced with (but not limited to) technical features with similar functions applied in the present application.

Claims

1. An infrared composite deep electrode, characterized in that: include: A deep electrode for implantation in human tissue, comprising a tube body, an electrode wire partially disposed in the tube body, and an electrode point disposed on the tube body and connected to the electrode wire; An infrared probe disposed on the deep electrode and an infrared connecting line partially disposed inside the tube body, wherein the infrared probe is connected to the infrared connecting line; Wherein, the infrared probe includes a near-infrared probe and / or a mid-infrared probe, and the infrared probe is an avalanche diode or a photodiode, which is used to emit infrared light to regulate the electrical activity of neuronal cells, and the tube body and / or the electrode point are configured not to block the infrared light emitted by the infrared probe; The electrode points and the infrared probes are staggeredly distributed on the tube body along the extension direction of the deep electrode, or the infrared probes are arranged on the electrode points; The electrode points are used to detect brain electrical signals.

2. The infrared composite deep electrode according to claim 1, characterized in that: The infrared probes are distributed on the deep electrode in a single row or in multiple rows along the extension direction thereof.

3. The infrared composite deep electrode according to claim 1, characterized in that: The electrode points include annular electrode points, and the annular electrode points are sleeved on the outer surface of the tube body.

4. The infrared composite deep electrode according to claim 3, characterized in that: The electrode points also include a plugging electrode point, and the plugging electrode point is arranged at the end of one end of the tube body.

5. The infrared composite deep electrode according to claim 3 or 4, characterized in that: A sealing plug is provided at the other end of the tube body, and the electrode wire and the infrared connection wire pass through the sealing plug.

6. The infrared composite deep electrode according to claim 3 or 4, characterized in that: The diameter of the tube body is 0.5-3 mm, and the diameter of the annular electrode point is 0.5-3 mm; when the number of the electrode points is greater than or equal to two, the distance between two adjacent electrode points is 2-10 mm.

7. The infrared composite deep electrode according to claim 1, characterized in that: The tube body is made of one of polyurethane material, silicone material or polyimide material; and / or, The electrode points and the electrode wires are both made of platinum-iridium alloy, stainless steel or nickel-chromium alloy.

8. The infrared composite deep electrode according to claim 1, characterized in that: An electrode wire sleeve is provided at the end of the electrode wire located outside the tube body, and an infrared connection wire sleeve is provided at the end of the infrared connection wire located outside the tube body.

9. A monitoring system, characterized in that: It comprises the infrared composite deep electrode as described in any one of claims 1 to 8, and a multimodal brain-computer interface subsystem, wherein the multimodal brain-computer interface subsystem is connected to the electrode wires and / or infrared connecting wires in the infrared composite deep electrode.

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