A riboflavin-based blood virus inactivation system

Abstract

The invention discloses a riboflavin method blood virus inactivation system, which includes a box shell, a temperature control system, a swing system and a control system. A frame is fixedly arranged in the box shell, a circulation channel is formed between the outer wall of the frame and the inner wall of the box shell, and a plurality of intervally arranged ultraviolet lamp boards are arranged in the frame and along its height direction. The upper and lower surfaces of the ultraviolet lamp board (3) are both provided with a plurality of lamp beads, and the left and right side walls of the frame are respectively provided with an air outlet and an air inlet connected to the cavity; the temperature control system includes a fan I, a fan II, a refrigeration system, an evaporator, an air inlet temperature sensor and an air outlet temperature sensor, the fan I is fixedly arranged on the outer side of the air outlet, and the fan II is fixedly arranged on the top of the circulation air duct; the swing system includes a power unit, a swing frame and a movable blood bag bracket. The beneficial effects of the invention are: compact structure, prevention of lamp bead burning, improved blood quality, uniform illumination, large preparation volume, and improved manufacturing efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of medical instruments, in particular to a riboflavin method blood virus inactivation system. Background Art

[0002] Blood pathogen inactivation is an important means to ensure blood safety. Blood pathogen inactivation refers to the destruction of the structure of viral proteins or viral nucleic acids by physical or chemical means, so that the viruses that may exist in the blood lose their ability to infect, cause disease and reproduce. Common methods of blood inactivation technology include Pasteur disinfection, organic solvent / detergent mixture (S / D) method, membrane filtration method, methylene blue photochemical method, psoralen photochemical method, riboflavin photochemical method, etc. Among them, the methylene blue method is widely used in China. This method requires methylene blue to reach a sufficient amount, but methylene blue has residual toxicity and the loss of plasma protein after treatment is large. Riboflavin photochemical method is a new and safer pathogen inactivation method with the characteristics of wide inactivation spectrum, safe additives, and better application prospects. The riboflavin virus inactivation method is to first add a certain amount of riboflavin to blood or blood products, and then place it in an ultraviolet light irradiation environment. After absorbing photon energy, the viral nucleic acid is destroyed, so that the pathogen loses its replication activity, thereby achieving the purpose of virus inactivation.

[0003] Although the existing inactivation cabinet can kill viruses in the blood, it still has the following defects: 1. The ultraviolet lamp will release a lot of heat when working, which will increase the temperature in the inactivation cabinet, and then heat the blood in the blood bag, thereby reducing the quality of the blood. 2. The blood bag is stationary, and the virus in the middle of the blood bag is not irradiated by ultraviolet light, resulting in uneven blood irradiation and incomplete virus inactivation. 3. The existing inactivation equipment can only perform inactivation once, and there is a defect of small preparation volume. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a riboflavin method blood virus inactivation system which has a compact structure, large preparation volume, improved manufacturing efficiency, prevents lamp bead burnout, improves blood quality, has uniform illumination, and is simple to operate.

[0005] The object of the present invention is achieved by the following technical scheme: a riboflavin method blood virus inactivation system, which includes a box shell, a temperature control system, a swing system and a control system, a frame is fixedly arranged in the box shell, a circulation channel is formed between the outer wall of the frame and the inner wall of the box shell, a plurality of spaced ultraviolet lamp boards are arranged in the frame and along its height direction, a horizontally arranged cavity is opened in the ultraviolet lamp board, a plurality of lamp beads are arranged on the upper and lower surfaces of the ultraviolet lamp board, and an air outlet and an air inlet connected to the cavity are respectively opened on the left and right side walls of the frame;

[0006] The temperature control system includes a fan I, a fan II, a refrigeration system, an evaporator, an air inlet temperature sensor and an air outlet temperature sensor. The evaporator is arranged in the circulation channel and is located on the right side of the frame. The refrigeration system is arranged below the box shell and is connected to the evaporator through a pipeline. The fan I is fixedly arranged on the outside of the air outlet, and the fan II is fixedly arranged on the top of the circulation air duct. The air outlet temperature sensor and the air inlet temperature sensor are respectively arranged on the left and right outer walls of the frame.

[0007] The swing system includes a power unit, a swing frame and a movable blood bag bracket. The power unit and the swing frame are both arranged in the frame. The swing frame is arranged at the rear side of the ultraviolet lamp board. A plurality of movable blood bag brackets are arranged on the swing frame. The movable blood bag brackets are arranged in the area formed by two adjacent ultraviolet lamp boards. The power unit is fixed on the bottom wall of the box shell. A driving mechanism for driving the swing frame to perform left and right reciprocating linear motion is arranged between the output shaft of the power unit and the swing frame.

[0008] The control system is electrically connected to an air inlet temperature sensor, an air outlet temperature sensor, a lamp bead, a fan I, a fan II, a power unit, and a refrigeration system.

[0009] A plurality of windows corresponding to the movable blood bag brackets are provided on the front end surface of the box shell, and a door is provided outside each window.

[0010] The power unit is arranged in the middle of the bottom of the swing frame, and the power unit is a motor.

[0011] Each movable blood bag bracket includes a bracket and two slide rails. The two slide rails are arranged toward the window and are respectively fixed on the left and right sides of the swing frame. The bracket is slidably installed between the two slide rails. A plurality of blood bags are placed on the top surface of the bracket.

[0012] A crossbeam fixed in the swing frame is arranged above the rear side of each movable blood bag bracket, and a light intensity sensor is arranged on each crossbeam, and the light intensity sensor is electrically connected to the control system.

[0013] The driving mechanism includes a slider, a guide rail, a channel steel, a connecting rod and a rolling bearing. The guide rail is horizontally arranged and fixed on the bottom wall of the box shell, the slider is fixed on the bottom surface of the swing frame, the slider is slidably installed on the guide rail, the channel steel is vertically arranged, one end of the connecting rod is fixed on the output shaft of the power unit, and the other end is rotatably installed with a rolling bearing, which is arranged in the channel steel and tangent to an inner side wall of the channel steel.

[0014] A plurality of heat dissipation teeth I are arranged on the inner wall of the ultraviolet lamp board cavity, and a plurality of heat dissipation teeth II are arranged on the front and rear outer walls of the ultraviolet lamp board.

[0015] The ultraviolet lamp panel comprises a lamp panel base, which is an aluminum plate or a copper plate with good thermal conductivity. An insulating layer, a conductive copper film and a circuit protection film are sequentially fixed on the upper and lower surfaces of the lamp panel base.

[0016] The lamp beads include lamp beads I and lamp beads II, which are distributed in a rectangular array, and lamp beads II penetrate the circuit protection film and are fixed on the conductive copper film, and lamp beads I are arranged on the outside of lamp beads II, and lamp beads I are arranged on the conductive copper film, and two groups of terminal heads are arranged on the conductive copper film, and both groups of terminal heads are electrically connected to the control system; the outside of the ultraviolet lamp board is provided with quartz glass covering the outside of lamp beads I and lamp beads II.

[0017] The box shell is provided with a display screen, a switch button and an alarm.

[0018] The invention has the following advantages: the invention has a compact structure, can prevent lamp beads from burning out, can improve blood quality, has uniform illumination, can produce a large amount, and can improve manufacturing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a structural schematic diagram of the present invention;

[0020] Figure 2 for Figure 1 Left view of

[0021] Figure 3 It is a structural schematic diagram of the ultraviolet lamp board;

[0022] Figure 4 for Figure 3 The main view;

[0023] Figure 5 for Figure 3 A top view of

[0024] Figure 6 for Figure 3 Left view of

[0025] Figure 7 for Figure 5 A partial enlarged view of part I;

[0026] Figure 8 for Figure 7 AA section view;

[0027] Fig. 9 is a wiring diagram of a conductive copper film;

[0028] Fig.10 It is the structural diagram of the swing system;

[0029] Fig.11 for Fig.10 Left view of

[0030] Fig.12 for Fig.11 A magnified view of part II;

[0031] In the figure, 1-box shell, 2-frame, 3-ultraviolet lamp board, 4-air outlet, 5-air inlet, 6-fan I, 7-fan II, 8-refrigeration system, 9-evaporator, 10-air inlet temperature sensor, 11-air outlet temperature sensor, 12-power unit, 13-swing frame, 14-window, 15-bracket, 16-slide rail, 17-blood bag, 18-beam, 19-light intensity sensor, 20-slider, 21-guide rail, 22-channel steel, 23-connecting rod, 24-rolling bearing, 25-heat dissipation tooth I, 26-heat dissipation tooth II, 27-insulating layer, 28-conductive copper film, 29-circuit protection film, 30-lamp bead I, 31-lamp bead II, 32-connection head, 33-quartz glass, 34-display screen, 35-switch button, 36-alarm, 37-door. DETAILED DESCRIPTION

[0032] The present invention is further described below in conjunction with the accompanying drawings, and the protection scope of the present invention is not limited to the following:

[0033] like Figures 1 to 12 As shown, a riboflavin method blood virus inactivation system comprises a box shell 1, a temperature control system, a swing system and a control system. A frame 2 is fixedly arranged in the box shell 1, a circulation channel is formed between the outer wall of the frame 2 and the inner wall of the box shell 1, a plurality of spaced ultraviolet lamp panels 3 are arranged in the frame 2 and along its height direction, a horizontally arranged cavity is provided in the ultraviolet lamp panel 3, a plurality of lamp beads are provided on the upper and lower surfaces of the ultraviolet lamp panel 3, and an air outlet 4 and an air inlet 5 communicating with the cavity are respectively provided on the left and right side walls of the frame 2. The lamp beads include lamp beads I30 and lamp beads II31, which are distributed in a rectangular array, and the lamp beads II31 penetrate the circuit protection film 29 and are fixed on the conductive copper film 28. The lamp beads I30 are arranged on the outside of the lamp beads II31, and the lamp beads I30 are arranged on the conductive copper film 28. The conductive copper film 28 is provided with two groups of terminal heads 32, and the two groups of terminal heads 32 are electrically connected to the control system; the outside of the ultraviolet lamp board 3 is provided with quartz glass 33 covered on the outside of the lamp beads I30 and the lamp beads II31, and the layers are installed to form an irradiation environment. When the system is not working, turn on the lamp beads I30 to sterilize the environment inside the box shell.

[0034] The temperature control system includes a fan I6, a fan II7, a refrigeration system 8, an evaporator 9, an air inlet temperature sensor 10 and an air outlet temperature sensor 11. The evaporator 9 is arranged in the circulation channel and is located on the right side of the rack 2 and on the side of the air inlet 5. The refrigeration system 8 is arranged below the box shell 1 and is connected to the evaporator 9 through a pipeline. The fan I6 is fixedly arranged on the outside of the air outlet 4, and the fan II7 is fixedly arranged on the top of the circulation air duct. The air outlet temperature sensor 11 and the air inlet temperature sensor 10 are respectively arranged on the left and right outer walls of the rack 2.

[0035] The swing system includes a power unit 12, a swing frame 13 and a movable blood bag bracket. The power unit 12 is arranged in the middle of the bottom of the swing frame 13, and the power unit 12 is a motor. The power unit 12 and the swing frame 13 are both arranged in the frame 2, the swing frame 13 is arranged on the rear side of the ultraviolet lamp board 3, and a plurality of movable blood bag brackets are arranged on the swing frame 13, and the movable blood bag brackets are arranged in the area formed by two adjacent ultraviolet lamp boards 3. The power unit 12 is fixedly arranged on the bottom wall of the box shell 1, and a driving mechanism for driving the swing frame 13 to do left and right reciprocating linear motion is arranged between the output shaft of the power unit 12 and the swing frame 13; the driving mechanism includes a slider 20, a guide rail 21, a channel steel 22, a connecting rod 23 and a rolling bearing 24, the guide rail 21 is horizontally arranged and fixedly arranged on the bottom wall of the box shell 1, the slider 20 is fixedly arranged on the bottom surface of the swing frame 13, the slider 20 is slidably installed on the guide rail 21, the channel steel 22 is vertically arranged, one end of the connecting rod 23 is fixedly arranged on the output shaft of the power unit 12, and the other end is rotatably installed with a rolling bearing 24, and the rolling bearing 24 is arranged in the channel steel 22 and tangent to an inner side wall of the channel steel 22. Each movable blood bag bracket includes a bracket 15 and two slide rails 16. The two slide rails 16 are arranged toward the window 14 and are respectively fixed on the left and right sides of the swing frame 13. The bracket 15 is slidably installed between the two slide rails 16. A plurality of blood bags 17 are placed on the top surface of the bracket 15. A crossbeam 18 fixed in the swing frame 13 is arranged above the rear side of each movable blood bag bracket. A light intensity sensor 19 is arranged on each crossbeam 18. The light intensity sensor 19 is electrically connected to the control system. The light intensity sensor 19 is used to detect the light intensity of the ultraviolet light, and adjusts the light intensity of the lamp beads through the control system to always maintain it within the effective light intensity range.

[0036] The control system is electrically connected to the air inlet temperature sensor 10, the air outlet temperature sensor 11, the lamp beads, the fan I6, the fan II7, the power unit 12, and the refrigeration system 8. The control system can control the start or shutdown of the power unit 12, the fan I6, the fan II7, and the refrigeration system 8. The control system reflects the temperature of the irradiated area after calculation based on the detected temperature, and controls the fan I6, the fan II7, the refrigeration system 8, and the evaporator 9 in real time to adjust the temperature thereof so that the temperature is maintained within the set range, thereby avoiding the deterioration of the blood quality due to the increase in temperature and protecting the lamp beads and other components, thereby improving the quality of the blood and facilitating the operation of the operator, and having the characteristics of a high degree of automation.

[0037] A plurality of windows 14 corresponding to the movable blood bag brackets are provided on the front end surface of the box shell 1, and a door 37 is provided outside each window 14 for placing and taking out the blood bag.

[0038] The inner wall of the cavity of the ultraviolet lamp board 3 is provided with a plurality of heat dissipation teeth I25, and the front and rear outer walls of the ultraviolet lamp board 3 are provided with a plurality of heat dissipation teeth II26, and the heat dissipation teeth II26 increase the heat dissipation area of ​​the ultraviolet lamp board 3. The ultraviolet lamp board 3 includes a lamp board base, and the lamp board base is an aluminum plate or a copper plate with good thermal conductivity. The upper and lower surfaces of the lamp board base are sequentially fixed with an insulating layer 27, a conductive copper film 28 and a circuit protection film 29, preferably an insulating layer 27 with good thermal conductivity, and a copper film is covered on the insulating layer 27, and the copper film is engraved or corroded to make it appear Fig. 9 The conductive copper film 28 is formed in the same direction, and then the lamp beads are welded to the corresponding positions of the conductive copper film 28, and finally covered with a layer of circuit protection film 29 to make a UV lamp board 3 that is conducive to heat dissipation and has a regular arrangement.

[0039] The box housing 1 is provided with a display screen 34 , a switch button 35 and an alarm 36 .

[0040] The working process of the present invention is as follows:

[0041] S1. Open one of the doors 37 to expose the window 14. The operator drags the bracket 15 of the movable blood bag bracket corresponding to the window 14 forward along the slide rail 16. After the bracket 15 passes through the window 14, the operator places the blood bag 17 on the top surface of the bracket 15, and then pushes the bracket 15 backward to allow the blood bag 17 to enter the irradiation station. Finally, the door 37 is closed to complete the placement of the blood bag 17.

[0042] S2, repeat the operation of step S1 to place the blood bag 17 on each bracket 15;

[0043] S3, energize one of the groups of terminal heads 32, the current is transmitted to the conductive copper film 28, the conductive copper film 28 transmits the current to the lamp bead II31, the lamp bead II31 emits ultraviolet light, at this time, the lower lamp bead II31 of the ultraviolet lamp board 3 above the blood bag 17 irradiates the top surface of the blood bag 17, and at the same time, the upper lamp bead II31 of the ultraviolet lamp board 3 below the blood bag 17 irradiates the bottom surface of the blood bag 17, thereby starting the virus inactivation;

[0044] S4. During the inactivation process, the power unit 12 is turned on, and the power unit 12 drives the connecting rod 23 to rotate. When the connecting rod 23 rotates half a circle, the connecting rod 23 drives the channel steel 22 to move to the right. When the connecting rod 23 rotates another half a circle, the connecting rod 23 drives the channel steel 22 to move to the left, thereby driving the slider 20 on the swing frame 13 to make reciprocating left and right movements on the guide rail 21, so as to achieve the purpose of shaking the blood, so that the blood is fully and evenly illuminated, and the purpose of inactivating the virus more thoroughly is achieved. In addition, the contact area between the blood and the ultraviolet light is increased, thereby shortening the inactivation time and improving the inactivation efficiency;

[0045] S5. During the inactivation process, a large amount of heat is generated on the lamp bead II31 and the conductive copper film 28. The heat is transferred to the heat dissipation teeth I25 through the insulating layer 27. The temperature around the ultraviolet lamp board 3 increases, and then the temperature in the circulation channel increases. When the air inlet temperature sensor 10 and the air outlet temperature sensor 11 detect that the temperature of the circulation channel exceeds the set temperature, the temperature sensor sends an electrical signal to the control system. After the control system receives the electrical signal, the control system controls the refrigeration system 8, the fan I6 and the fan II7 to start. The fan I6 discharges the heat in the inner cavity of the ultraviolet lamp board 3 into the circulation channel. Fan II7 then discharges the heat to the vicinity of the evaporator 9, the refrigeration system 8 cools the evaporator 9, and the fan I6 draws the low-temperature gas around the evaporator 9 into the cavity of the ultraviolet lamp board 3, thereby achieving the purpose of cooling the ultraviolet lamp board 3, and then cooling the lamp bead II31, avoiding the lamp bead II31 from burning due to overhigh temperature; when the temperature drops to within the set temperature range, the control system controls the refrigeration system 8, fan II7, and fan I6 to turn off, so that the surface temperature of the blood bag 17 is always within the set range, avoiding the deterioration of blood quality due to increased temperature, that is, improving the quality of blood.

[0046] In addition, the blood in a plurality of blood bags 17 can be inactivated, which greatly increases the preparation volume and the manufacturing efficiency compared with the traditional single-piece inactivation method.

[0047] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A riboflavin method blood virus inactivation system, characterized in that: It comprises a box shell (1), a temperature adjustment system, a swing system and a control system. A frame (2) is fixedly arranged in the box shell (1). A circulation channel is formed between the outer wall of the frame (2) and the inner wall of the box shell (1). A plurality of ultraviolet lamp panels (3) are arranged at intervals in the frame (2) and along its height direction. A horizontal cavity is provided in the ultraviolet lamp panel (3). A plurality of lamp beads are provided on the upper and lower surfaces of the ultraviolet lamp panel (3). An air outlet (4) and an air inlet (5) communicating with the cavity are respectively provided on the left and right side walls of the frame (2). The temperature control system comprises a fan I (6), a fan II (7), a refrigeration system (8), an evaporator (9), an air inlet temperature sensor (10) and an air outlet temperature sensor (11); the evaporator (9) is arranged in the circulation channel and is located on the right side of the frame (2) and on the air inlet side; the refrigeration system (8) is arranged below the box shell (1) and is connected to the evaporator (9) via a pipeline; the fan I (6) is fixedly arranged on the outside of the air outlet (4); the fan II (7) is fixedly arranged on the top of the circulation air duct; the air outlet temperature sensor (11) and the air inlet temperature sensor (10) are respectively arranged on the left and right outer side walls of the frame (2); The swing system comprises a power unit (12), a swing frame (13) and a movable blood bag bracket. The power unit (12) and the swing frame (13) are both arranged in the frame (2). The swing frame (13) is arranged on the rear side of the ultraviolet lamp board (3). A plurality of movable blood bag brackets are arranged on the swing frame (13). The movable blood bag brackets are arranged in the area formed by two adjacent ultraviolet lamp boards (3). The power unit (12) is fixed on the bottom wall of the box shell (1). A driving mechanism for driving the swing frame (13) to perform left and right reciprocating linear motion is arranged between the output shaft of the power unit (12) and the swing frame (13). The control system is electrically connected to an air inlet temperature sensor (10), an air outlet temperature sensor (11), a lamp bead, a fan I (6), a fan II (7), a power unit (12), and a refrigeration system (8); Each movable blood bag bracket comprises a bracket (15) and two slide rails (16), the two slide rails (16) are both arranged toward the window (14) and are respectively fixed to the left and right sides of the swing frame (13), the bracket (15) is slidably installed between the two slide rails (16), and a plurality of blood bags (17) are placed on the top surface of the bracket (15); The driving mechanism comprises a slider (20), a guide rail (21), a channel steel (22), a connecting rod (23) and a rolling bearing (24); the guide rail (21) is horizontally arranged and fixedly mounted on the bottom wall of the box shell (1); the slider (20) is fixedly mounted on the bottom surface of the swing frame (13); the slider (20) is slidably mounted on the guide rail (21); the channel steel (22) is vertically arranged; one end of the connecting rod (23) is fixedly mounted on the output shaft of the power unit (12); and the other end is rotatably mounted with a rolling bearing (24); the rolling bearing (24) is arranged in the channel steel (22) and is tangent to an inner side wall of the channel steel (22); A plurality of heat dissipation teeth I (25) are arranged on the inner wall of the cavity of the ultraviolet lamp board (3), and a plurality of heat dissipation teeth II (26) are arranged on the front and rear outer walls of the ultraviolet lamp board (3); The ultraviolet lamp panel (3) comprises a lamp panel base, the lamp panel base is an aluminum plate or a copper plate with good thermal conductivity, and an insulating layer (27), a conductive copper film (28) and a circuit protection film (29) are sequentially fixed on the upper and lower surfaces of the lamp panel base; The lamp beads include lamp beads I (30) and lamp beads II (31), the lamp beads II (31) are distributed in a rectangular array, and the lamp beads II (31) penetrate the circuit protection film (29) and are fixed on the conductive copper film (28), the lamp beads I (30) are arranged on the outside of the lamp beads II (31), and the lamp beads I (30) are arranged on the conductive copper film (28), and the conductive copper film (28) is provided with two groups of wiring heads (32), and the two groups of wiring heads (32) are electrically connected to the control system; the outside of the ultraviolet lamp board (3) is provided with quartz glass (33) covering the outside of the lamp beads I (30) and the lamp beads II (31).

2. A riboflavin blood virus inactivation system according to claim 1, characterized in that: A plurality of windows (14) corresponding to the movable blood bag brackets are provided on the front end surface of the box shell (1), and a door (37) is provided outside each window (14).

3. The riboflavin blood virus inactivation system according to claim 1, characterized in that: The power unit (12) is arranged in the middle of the bottom of the swing frame (13), and the power unit (12) is a motor.

4. The riboflavin blood virus inactivation system according to claim 1, characterized in that: A crossbeam (18) fixed in the swing frame (13) is arranged above the rear side of each movable blood bag bracket, and a light intensity sensor (19) is arranged on each crossbeam (18), and the light intensity sensor (19) is electrically connected to the control system.

5. The riboflavin blood virus inactivation system according to claim 1, characterized in that: The box housing (1) is provided with a display screen (34), a switch button (35) and an alarm (36).

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