Compositions containing vitamin B12

Abstract

The object of the present invention is to provide a 12 and can inhibit the production of vitamin B12 by light exposure. 12 By making the composition containing vitamin B 12 The composition contains polyoxyethylene sorbitan fatty acid ester and is set to be relative to vitamin B 12 1 part by weight of polyoxyethylene sorbitan fatty acid ester is less than 10 parts by weight, so that even if it is exposed to light under harsh conditions, it can inhibit the growth of vitamin B 12 The decomposition of vitamin B 12 The photostabilization effect of the same type.

Description

Technical Field

[0001] The present invention relates to a compound containing vitamin B 12 and can inhibit the production of vitamin B12 due to light exposure. 12 The composition of the decomposition of the class. Background Art

[0002] Vitamin B 12 Vitamin B is a type of water-soluble vitamin and is an essential nutrient for maintaining life. 12 Vitamin B 12 It is effective in preventing or improving symptoms such as deficiency, megaloblastic anemia, broad tapeworm disease, pernicious anemia, malabsorption syndrome, eye fatigue, nutritional anemia, pregnancy anemia, neuralgia, and improving rough skin, and can be used in food, oral care products, pharmaceuticals, cosmetics, etc. On the other hand, it is known that vitamin B 12 The type is easily decomposed by light exposure, and contains vitamin B 12 In terms of the practical application of products such as vitamin B 12 It is essential that the class be photostable.

[0003] In the past, vitamin B 12 Various reports have been made on the technology of photo-stable preparations. For example, Patent Document 1 discloses a method of preparing a preparation containing vitamin B12. 12 and butanol preparations can 12 In addition, Patent Document 2 discloses a method for preparing a soluble fiber containing vitamin B1 12 The vitamin composition of the vitamin stabilizer having a specific phenylpropylene carbonyl structure can 12 In addition, Patent Document 3 discloses that the 12 Add cyclodextrin or its derivatives to make vitamin B 12 Achieve photostabilization.

[0004] Thus, in the past, although the pursuit of vitamin B 12 However, in recent years, the demand for product diversification and quality improvement has increased. In order to meet such demands, it is expected to develop a new type of vitamin B 12 New technology for photostabilization of this class.

[0005] Prior art literature

[0006] Patent Literature

[0007] Patent Document 1: International Publication No. 2008 / 113483

[0008] Patent Document 2: Japanese Patent Application Laid-Open No. 2007-125018

[0009] Patent Document 3: Japanese Patent Application Laid-Open No. 4-49239 Summary of the Invention

[0010] Problems to be solved by the invention

[0011] The object of the present invention is to provide a 12 and can inhibit the production of vitamin B12 by light exposure. 12 The composition of the decomposition of the class.

[0012] The present inventors have conducted intensive research to solve the above problems and have found that by adding vitamin B 12 The composition contains polyoxyethylene sorbitan fatty acid ester and is set to be relative to vitamin B 12 1 part by weight of polyoxyethylene sorbitan fatty acid ester is less than 10 parts by weight, so that even if it is exposed to light under harsh conditions, it can inhibit the growth of vitamin B 12 Decomposition of vitamin B 12 The present invention has been completed through further research based on the above findings.

[0013] That is, the present invention provides the following disclosed aspects of the invention.

[0014] Item 1. A kind of vitamin B 12 A composition of the type, characterized in that

[0015] Vitamin B 12 Compositions containing vitamin B 12 and polyoxyethylene sorbitan fatty acid esters, and relative to vitamin B 12 For 1 part by weight of the compound, the amount of polyoxyethylene sorbitan fatty acid ester is less than 10 parts by weight.

[0016] Item 2. The vitamin B-containing composition according to Item 1. 12 A composition of the type wherein

[0017] Vitamin B 12 The composition also contains vitamin E.

[0018] Item 3. The vitamin B-containing composition according to Item 2 12 A composition of the type wherein

[0019] Compared to vitamin B 12 1 part by weight of vitamins and 0.00125 to 1000 parts by weight of vitamin E.

[0020] Item 4. The vitamin B-containing composition according to any one of Items 1 to 3. 12 A composition of the type wherein

[0021] Vitamin B 12 The composition of this type is an aqueous composition.

[0022] Effects of the Invention

[0023] According to the present invention, it is possible to inhibit the degradation of vitamin B12 caused by light exposure. 12 The decomposition of vitamin B 12 Storage stability of various products of this type. DETAILED DESCRIPTION

[0024] 1. Contains Vitamin B 12 Composition of classes

[0025] Vitamin B-containing 12 The composition is characterized in that it contains vitamin B 12 and polyoxyethylene sorbitan fatty acid esters, and relative to vitamin B 12 1 part by weight of the vitamin B-containing compound of the present invention, and 10 parts by weight of the polyoxyethylene sorbitan fatty acid ester. 12 The composition of the class is described in detail.

[0026] [Vitamin B 12 kind]

[0027] Vitamin B 12 Vitamin B 12 (cyanocobalamin), its derivatives, and their salts. Regarding vitamin B used in the present invention 12 The type of vitamin B is not particularly limited as long as it can be incorporated into food and beverages, oral care products, pharmaceuticals, cosmetics and other products. 12 Derivatives of vitamin B include methylcobalamin, hydroxocobalamin, adenosylcobalamin, and hydrocobalamin. 12 and salts of their derivatives, for example, carboxylates such as acetate, trifluoroacetate, butyrate, palmitate, stearate, fumarate, maleate, succinate, malonate, lactate, tartrate, and citrate; organic sulfonates such as methanesulfonate, toluenesulfonate, and p-toluenesulfonate; inorganic acid salts such as hydrochloride, sulfate, nitrate, and phosphate; organic amine salts such as methylamine, triethylamine, and triethanolamine; alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium and magnesium; ammonium salts, etc.

[0028] These B vitamins 12 One type of class may be used alone, or two or more types may be used in combination.

[0029] These B vitamins 12 Among the class, cyanocobalamin is preferably mentioned.

[0030] About the vitamin B-containing 12 Vitamin B in the composition 12 The concentration of vitamin B 12 The shape of the composition, product form, etc. may be appropriately set, and for example, it can be 0.0001 to 0.2 wt %, preferably 0.0002 to 0.02 wt %, and more preferably 0.0002 to 0.002 wt %.

[0031] [Polyoxyethylene sorbitan fatty acid ester]

[0032] In order to obtain vitamin B 12 The photostabilization of the present invention contains vitamin B 12 The composition of vitamin B 12 The polyoxyethylene sorbitan fatty acid ester is contained in an amount of 10 parts by weight or less to 1 part by weight.

[0033] Polyoxyethylene sorbitan fatty acid esters are compounds formed by the condensation of ethylene oxide with a sorbitan fatty acid ester, which is a monoester, diester, or triester of a fatty acid and sorbitan. The number of carbon atoms in the fatty acid constituting the polyoxyethylene sorbitan fatty acid esters ranges from 8 to 30, preferably from 10 to 22, and more preferably from 12 to 18. Furthermore, the average number of moles of ethylene oxide added to the polyoxyethylene sorbitan fatty acid esters ranges from 6 to 160, preferably from 6 to 60, and more preferably from 6 to 30. Specific examples of polyoxyethylene sorbitan fatty acid esters include polysorbate 20 (polyoxyethylene (20) sorbitan monopalmitate), polysorbate 40 (polyoxyethylene (20) sorbitan monolaurate), polysorbate 60 (polyoxyethylene (20) sorbitan monostearate), polysorbate 65 (polyoxyethylene (20) sorbitan tristearate), polysorbate 80 (polyoxyethylene (20) sorbitan monooleate), polysorbate 85 (polyoxyethylene (20) sorbitan trioleate), PEG-6 sorbitan stearate, PEG-20 sorbitan isostearate, PEG-6 sorbitan oleate, and polysorbate 85.

[0034] These polyoxyethylene sorbitan fatty acid esters may be used alone or in combination of two or more.

[0035] Among these polyoxyethylene sorbitan fatty acid esters, vitamin B 12 From the viewpoint of photostabilization of the type, preferably, polysorbate 80 is used.

[0036] In the present invention, vitamin B 12 In the composition of this class, as vitamin B 12 The ratio of the two when they coexist with polyoxyethylene sorbitan fatty acid esters relative to vitamin B 12 The amount of polyoxyethylene sorbitan fatty acid ester may be 10 parts by weight or less based on 100 parts by weight of the compound, preferably 1 to 10 parts by weight, more preferably 2.5 to 10 parts by weight.

[0037] In addition, regarding the vitamin B-containing 12 The concentration of the polyoxyethylene sorbitan fatty acid ester in the composition can be appropriately set within the range satisfying the above ratio, and is, for example, 0.001 to 0.1% by weight, preferably 0.0025 to 0.1% by weight, and more preferably 0.005 to 0.1% by weight.

[0038] [Vitamin E]

[0039] In the present invention, vitamin B 12 In the composition of the class, in addition to vitamin B 12 In addition to vitamins and polyoxyethylene sorbitan fatty acid esters, vitamin E may also be contained. By further containing vitamin E, the effect of vitamin B12 can be more effectively achieved. 12 Photostabilization of the class.

[0040] Vitamin E refers to vitamin E (tocopherol, tocotrienol) and derivatives thereof. About the kind of vitamin E used in the present invention, with being able to be incorporated into products such as food and beverage, oral care products, pharmaceuticals, cosmetics as limit, there is no particular restriction. For example, tocopherol and tocotrienol can be any one of α-, β-, γ- and δ-, in addition, can also be any one of d body or dl body. In addition, for example, as derivatives of vitamin E, tocopherol organic acid esters such as tocopherol acetate, tocopherol succinate, tocopherol linoleate, tocopherol linolenate, tocopherol nicotinate, tocopherol (linoleic acid / oleic acid) ester etc. can be listed.

[0041] These vitamin E compounds may be used alone or in combination of two or more.

[0042] Among these vitamin E types, vitamin B 12 From the viewpoint of photostabilization of the type, preferably, a tocopherol derivative is used, and more preferably, tocopherol acetate is used.

[0043] In the case of the vitamin B 12 In the case of a composition containing vitamin E, as a vitamin B 12 The ratio of vitamin B to vitamin E can be exemplified by: 12 For 1 part by weight of vitamins, the amount of vitamin E is 0.00125 to 1000 parts by weight, preferably 0.025 to 250 parts by weight, and more preferably 2.5 to 250 parts by weight.

[0044] In addition, when the vitamin B-containing 12 In the case of a composition containing vitamin E, as a composition containing vitamin B 12 The concentration of vitamin E in the composition of the vitamin E compound is, for example, 0.00025 to 0.1% by weight, preferably 0.0005 to 0.05% by weight, and more preferably 0.0005 to 0.005% by weight.

[0045] [Chelating agent]

[0046] Vitamin B-containing 12 The composition may further contain a chelating agent. The type of chelating agent used in the present invention is not particularly limited, as long as it can be incorporated into products such as food and beverages, oral care products, pharmaceuticals, and cosmetics. Examples thereof include edetic acid, citric acid, succinic acid, and salts thereof. Examples of salt forms include alkali metal salts such as sodium salts and potassium salts. These chelating agents may be used alone or in combination of two or more.

[0047] Among these chelating agents, preferably, edetic acid and its salts are used, and more preferably, sodium edetate is used.

[0048] In addition, when the vitamin B-containing 12 In the case of compositions containing chelating agents, vitamin B 12 The concentration of the chelating agent in the composition is not particularly limited, and may be, for example, 0.001 to 0.3 wt %, preferably 0.005 to 0.1 wt %, and more preferably 0.01 to 0.1 wt %.

[0049] [Polyol]

[0050] Vitamin B-containing 12 The composition of the present invention may further contain a polyol. Examples of the polyol used in the present invention include ethylene glycol, 1,3-butylene glycol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, and glycerol. These polyols may be used alone or in combination of two or more.

[0051] Among these polyols, preferably, propylene glycol is used.

[0052] In addition, when the vitamin B-containing 12 In the case of compositions containing polyols, vitamin B 12 The concentration of the polyol in the composition is not particularly limited, and may be, for example, 0.01 to 10% by weight, preferably 0.1 to 5% by weight, and more preferably 0.1 to 1% by weight.

[0053] [Other ingredients]

[0054] In the present invention, vitamin B 12 In addition to the above ingredients, the composition may also contain vitamin B 12 The shape and product form of the composition contain various pharmacological ingredients, food raw materials, additives and other ingredients. Such ingredients can be obtained by 12 The shape of the composition and the product form of the composition can be appropriately selected to use the ingredients, for example, water, pharmacological ingredients, cooling agents, surfactants (except polyoxyethylene sorbitan fatty acid esters), oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, water-soluble polymers, metal soaps, monovalent lower alcohols, pH regulators, buffers, antioxidants, UV inhibitors, preservatives, fragrances, powders, thickeners, pigments, etc. These ingredients can be used alone or in combination of two or more. The concentration of these ingredients can be appropriately set according to the type of ingredients used, the shape of the composition and the product form, etc.

[0055] [Contains vitamin B 12 The shape of the composition and product form, etc.]

[0056] Vitamin B-containing 12 The composition can be any of an aqueous composition or a non-aqueous composition. 12 Although vitamin B12 has a tendency to be easily decomposed by light exposure in an aqueous composition, according to the present invention, the degradation of vitamin B12 caused by light exposure can be effectively suppressed even in an aqueous composition. 12 In view of the effects of the present invention, as the vitamin B-containing 12 Preferred examples of such compositions include aqueous compositions.

[0057] An aqueous composition is a composition containing water. Specifically, the concentration of water in the aqueous composition is 50% by weight or greater, preferably 50 to 99.99% by weight, and more preferably 50 to 99.8% by weight. Examples of the form of the aqueous composition include liquid, gel, and paste.

[0058] Contains vitamin B12 When the composition is an aqueous composition, the pH thereof is, for example, 4.0 to 8.0, preferably 5.0 to 7.7, and more preferably 5.5 to 7.0.

[0059] In addition, a non-aqueous composition refers to a composition that does not substantially contain water except for water inevitably contained due to moisture absorption of the ingredients. Examples of the form of the non-aqueous composition include powder, granules, tablets, pills, and ointments.

[0060] About the vitamin B-containing 12 The product form of the composition is not particularly limited, and examples thereof include food and beverages, oral care products, pharmaceuticals, and cosmetics.

[0061] Examples of food and beverages include beverages such as soft drinks, alcoholic beverages, nutritional drinks, coffee, tea, milk, fruit juice drinks, and soft drinks; supplements such as tablets, granules, powders, gels, granules, suspensions, syrups, and capsules (soft capsules and hard capsules); side dishes such as cheese, wieners, sausages, ham, and processed seafood; and desserts such as ice cream, cookies, cakes, jellies, puddings, candies, chewing gum, yogurt, gummy candies, chocolates, and biscuits.

[0062] Examples of oral care products include dentifrices such as toothpaste, powder dentifrice, and liquid dentifrice; tooth pastes; mouthwashes such as mouthwash and gargle; oral pastes, oral sprays, orally disintegrating films, gels, lozenges, tablets, chewable tablets, and oral ointments.

[0063] Examples of pharmaceuticals include pharmaceuticals for oral administration such as powders, granules, tablets, capsules, pills, and liquids; pharmaceuticals for subcutaneous, intravascular, or intraperitoneal administration such as infusions and injections; pharmaceuticals for application to the skin or mucous membranes such as liquid preparations (including lotions, sprays, aerosols, and emulsions), water-soluble ointments, oily ointments, creams, foams, gels, patches, eye drops, and eyewashes.

[0064] Examples of the cosmetics include basic cosmetics such as ointments, creams, emulsions, lotions, lotions, masks, and gels; and color cosmetics such as foundations, eye shadows, lipsticks, and blushers.

[0065] Example

[0066] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.

[0067] Test Example 1

[0068] An aqueous composition of the composition shown in Table 1 was prepared. 500 ml of the resulting aqueous composition was filled into a 500 ml transparent container (made of polyethylene terephthalate) and allowed to stand for 35 days in a room exposed to direct sunlight during the day (10 cm from a south window). After standing for 35 days, the appearance of the aqueous composition was visually observed, and the storage stability of cyanocobalamin was determined according to the following criteria. It should be noted that since cyanocobalamin exhibits a pink hue and fades when decomposed, in this test, the greater the fading, the more cyanocobalamin decomposition has progressed.

[0069] Storage stability of cyanocobalamin

[0070] ◎: The color tone is the same as that immediately after production.

[0071] ○: Slight discoloration was observed compared to immediately after production, but within the acceptable range.

[0072] ×: Significant discoloration was observed compared to immediately after production, which is unacceptable.

[0073] XX: The color faded significantly and became almost colorless.

[0074] The results are shown in Table 1. The results showed that even when cyanocobalamin and polysorbate 80 coexisted in an aqueous composition, the decomposition of cyanocobalamin due to light exposure could not be suppressed when the amount of polysorbate 80 exceeded 10 parts by weight relative to 1 part by weight of cyanocobalamin. In contrast, when polysorbate 80 coexists with cyanocobalamin in an aqueous composition and the amount of polysorbate 80 is 10 parts by weight or less relative to 1 part by weight of cyanocobalamin, it was confirmed that the decomposition of cyanocobalamin due to light exposure can be suppressed. Furthermore, it was clarified that when an aqueous composition contains cyanocobalamin and 10 parts by weight or less of polysorbate 80 relative to 1 part by weight of cyanocobalamin, and also contains tocopherol acetate, the decomposition of cyanocobalamin due to light exposure can be particularly effectively suppressed.

[0075] [Table 1]

[0076]

[0077] Recipe Example

[0078] Aqueous compositions were prepared having the compositions shown in Table 2. The storage stability of cyanocobalamin was evaluated for the obtained aqueous compositions by the same method as in Test Example 1. The results showed that the decomposition of cyanocobalamin due to light exposure was effectively suppressed in all the aqueous compositions.

[0079] [Table 2]

[0080]

Claims

1. Use of polysorbate 80 for photostabilization of cyanocobalamin, wherein: A cyanocobalamin-containing composition is obtained by adding 10 parts by weight or less of polysorbate 80 to 1 part by weight of cyanocobalamin.

2. Use of a composition containing polysorbate 80 and vitamin E for photostabilization of cyanocobalamin, wherein: A cyanocobalamin-containing composition is obtained by adding 10 parts by weight or less of polysorbate 80 and 0.00125 to 1000 parts by weight of vitamin E to 1 part by weight of cyanocobalamin.

3. The use according to claim 1 or 2, wherein The cyanocobalamin-containing composition further comprises a chelating agent.

4. The use according to claim 1 or 2, wherein The cyanocobalamin-containing composition further comprises a polyol.

5. The use according to claim 1 or 2, wherein The cyanocobalamin-containing composition is an aqueous composition.

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