Electrode attachment position determination method, device, and computer-readable storage medium

Abstract

The present disclosure provides a method, device, and computer-readable storage medium for determining electrode attachment positions. The method includes: determining a three-dimensional head model of a target user and a target treatment area within the three-dimensional head model of the target user; determining resizing parameters so that the resulting three-dimensional head model matches a standard three-dimensional head model, and resizing the target treatment area according to the determined resizing parameters; determining the degree of match between the resizing target treatment area and the optimal treatment area corresponding to an available electrode attachment scheme in a standard template library; and performing an inverse resizing transformation on the attachment area determined by the available electrode attachment scheme with the highest degree of match to obtain the attachment area of ​​the electrode element on the three-dimensional head model. This method helps reduce computational complexity.

Description

Technical Field

[0001] The present disclosure belongs to the field of medical equipment, and particularly relates to a method and device for determining an electrode attachment position, and a computer-readable storage medium. Background Art

[0002] This section is intended to provide a background or context for the embodiments of the present disclosure. No admission is made that the description herein is prior art by virtue of its inclusion in this section.

[0003] Tumor Therapeutic Fields (TTFIELD) uses alternating current (AC) electric fields to inhibit tumor cell proliferation. To achieve the best treatment outcome for cancer patients (i.e., target users), the electric field intensity distribution in the tumor area is typically simulated based on a 3D model of the patient's head (including the skull and underlying brain tissue), the tumor area, and candidate electrode placement locations. This method is inherently complex and computationally intensive. Summary of the Invention

[0004] The present disclosure provides a method and device for determining an electrode attachment position, and a computer-readable storage medium.

[0005] The present disclosure provides the following solution: a method for determining an electrode attachment position, comprising:

[0006] determining a three-dimensional head model of a target user and a target treatment area in the three-dimensional head model of the target user;

[0007] Determining resizing parameters so that a three-dimensional head model obtained by resizing the target user's head according to the resizing parameters matches a standard three-dimensional head model, and resizing the target treatment area according to the determined resizing parameters;

[0008] Determining a degree of match between the target treatment area after the size transformation and an optimal treatment area corresponding to an electrode attachment scheme available in a standard template library, wherein the standard template library pre-stores a correspondence between electrode element attachment schemes and optimal treatment areas, and the electrode attachment scheme indicates an attachment area of ​​the electrode element in the standard three-dimensional head model;

[0009] The attachment area determined by an available electrode attachment solution with the highest matching degree is subjected to an inverse transformation of the size transformation to obtain the attachment area of ​​the electrode element on the three-dimensional head model of the target user.

[0010] The following scheme is provided in an embodiment of the present disclosure: an electrode attachment position determination device, comprising: at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the aforementioned electrode attachment position determination method.

[0011] The following solution is provided in an embodiment of the present disclosure: a computer-readable storage medium storing a program, which, when executed by a processor, causes the processor to execute the aforementioned electrode attachment position determination method.

[0012] After establishing a standard template library, the target treatment area of ​​the target user is mapped to a standard 3D head model using a simple spatial transformation. The degree of match between the transformed tumor area and the optimal treatment area corresponding to each electrode attachment scheme is calculated to determine an electrode attachment scheme. This electrode attachment scheme is then mapped to the 3D head model of the target user to determine the electrode attachment scheme for the target user's scalp. This entire calculation process does not require computer simulation of the spatial distribution of the electric field intensity inside the target user's skull, making the computational effort very low. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 4 is a flow chart of a method for determining an electrode attachment position according to an embodiment of the present disclosure.

[0014] Figure 2 This is a diagram showing the effects of some steps in the method for determining the electrode attachment position according to an embodiment of the present disclosure.

[0015] Figure 3 This is a diagram showing the effects of some steps in the method for determining the electrode attachment position according to an embodiment of the present disclosure.

[0016] Figure 4 This is a diagram showing the effects of some steps in the method for determining the electrode attachment position according to an embodiment of the present disclosure.

[0017] Figure 5 Schematic diagram of the structure of an electrode attachment position determination device according to an embodiment of the present disclosure. DETAILED DESCRIPTION

[0018] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in the present disclosure may be combined with each other. The present disclosure will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0019] Figure 1This is a flow chart of a method for determining electrode attachment positions according to an embodiment of the present disclosure. This method is used to determine the attachment area of ​​an electrode element on the head of a target user (e.g., a head tumor patient). From a device perspective, the execution body of this process can be one or more electronic devices or computing modules within these electronic devices; from a program perspective, the execution body of this process can be the program installed on these electronic devices.

[0020] Figure 1 The process may include the following steps 101 to 104.

[0021] Step 101: Determine a three-dimensional head model of a target user and a target treatment area in the three-dimensional head model of the target user.

[0022] The target treatment area is, for example, a tumor area. The tumor area may be concentrated in one location or dispersed across multiple locations. The target treatment area may also be any other area requiring electric field stimulation, not limited to the tumor area. An alternating electric field is applied to the target treatment area via the electrode elements.

[0023] Step 102: Determine size transformation parameters so that the target user's head 3D model, obtained after the size transformation according to the size transformation parameters, matches the standard head 3D model, and transform the target treatment area according to the determined size transformation parameters.

[0024] Sizing parameters refer to the scale factor, direction, and center point of stretching or compression.

[0025] In the embodiment of the present disclosure, a standard head 3D model is set. Figure 2 The target user's head size is relatively small, and the target user's head 3D model and the target treatment area are stretched in the three coordinate axis directions in the three-dimensional rectangular coordinate system, so that the stretched target user's head 3D model is as consistent as possible with the standard head 3D model. Figure 2 In addition to the target treatment area, areas of different grayscale represent the optimal treatment areas corresponding to different electrode attachment schemes.

[0026] The present disclosure does not limit how to evaluate whether two 3D head models are compatible. For example, the difference in volume between the two 3D head models can be determined to be sufficiently small, the difference in surface area between the two 3D head models to be sufficiently small, or the difference in diameter of the minimum enclosing cylinders between the two 3D head models to be sufficiently small. For another example, the top of the head, forehead, back of the forehead, earlobe, or the intersection of the ear and scalp in a standard 3D head model can be selected as the transformation termination reference points. The size transformation parameters obtained when the corresponding points of the target user's 3D head model partially or completely overlap with these transformation reference points are the determined size transformation parameters.

[0027] Step 103: Determine the degree of match between the target treatment area after size transformation and the optimal treatment area corresponding to the electrode attachment scheme available in the standard template library, wherein the standard template library pre-stores the correspondence between the electrode element attachment scheme and the optimal treatment area, and the electrode attachment scheme indicates the attachment area of ​​the electrode element in the standard head three-dimensional model.

[0028] Once the shape, size, and number of electrode elements are determined, the range of adjustment available for their attachment area on the head is limited. For example, the electrode elements can only move and rotate within a relatively small range. Consequently, the number of electrode attachment solutions in the standard template library is also relatively limited.

[0029] Each electrode attachment scheme produces a different distribution of electric field strength within the target user's skull. Therefore, for each electrode attachment scheme, a spatial region (referred to herein as the optimal treatment region) where the therapeutic effect is sufficiently good can be determined. Within this spatial region, the AC electric field strength is sufficiently high.

[0030] The larger the overlapping volume between the target treatment area after the target user's size is transformed and the optimal treatment area corresponding to a certain electrode attachment scheme, the better the treatment effect of this electrode attachment scheme on the target user.

[0031] This disclosure does not limit the algorithm for evaluating the degree of match between the target treatment area after size transformation and the optimal treatment area corresponding to an electrode attachment scheme. For example, the degree of match can be evaluated based on the volume of the overlapping area between the two or the volume of the overlapping area of ​​the minimum enclosing sphere between the two.

[0032] In the case that the target user's head and scalp are intact, all electrode attachment schemes in the standard template library are available.

[0033] In the case where the target user's head or scalp has an avoidance area, the target treatment area and the avoidance area will be resized according to the determined size transformation parameters, and the attachment area of ​​the electrode element indicated by the electrode attachment scheme available in the standard template library in the standard head three-dimensional model does not overlap with the avoidance area after size transformation.

[0034] For example, if the target user's head has areas of skull bone loss, surgical incisions, or scalp damage, these areas must be avoided by the electrode element attachment area. If an electrode attachment plan specifies an electrode element attachment area that overlaps with these avoidance areas, the plan is unsuitable. Such electrode attachment plans can be eliminated before or after the matching calculation.

[0035] In some embodiments, the electrode attachment plan indicates the attachment areas of all electrode elements in the standard 3D head model. For example, a tumor electric field therapy device has two pairs of electrode elements, and the attachment areas of these two pairs of electrode elements on the standard 3D head model constitute an electrode attachment plan.

[0036] Step 104: Perform an inverse transformation of the size transformation on the attachment area determined by an available electrode attachment solution with the highest matching degree, so as to obtain the attachment area of ​​the electrode element on the three-dimensional head model of the target user.

[0037] For example, the attachment area determined by an available electrode attachment solution with the highest matching degree is subjected to the inverse transformation of the size transformation, and the orientation of the electrode element after the inverse transformation is used as the attachment orientation of the electrode element on the three-dimensional head model.

[0038] Here, the inverse transformation is defined as performing a size transformation on a three-dimensional model and then performing an inverse transformation of the size transformation to restore the three-dimensional model to its original state.

[0039] A single electrode element may be a whole electrode element, or may be divided into a plurality of sub-electrode elements connected in parallel, which is not limited in the present disclosure. Figure 3 In the example shown, an electrode element is composed of nine parallel sub-electrode elements. The attachment area of ​​an electrode element can be determined by the cross positioning method, that is, the position of the center coordinates of the electrode element on the target user's scalp and the rotation angle of the electrode element are determined.

[0040] After determining the attachment position of the electrode element on the target user's head, the size of the electrode element actually attached to the target user's head may be equal to or different from the size of the electrode element in the standard template library, which is not particularly limited in this disclosure.

[0041] After establishing a standard template library, the target treatment area of ​​the target user is mapped to a standard 3D head model through a simple spatial transformation. The degree of match between the transformed tumor area and the optimal treatment area corresponding to each electrode attachment scheme is calculated to determine an electrode attachment scheme. This electrode attachment scheme is then mapped to the 3D head model of the target user to determine the electrode attachment scheme for the target user's scalp. This entire calculation process does not require computer simulation of the spatial distribution of the electric field intensity inside the target user's skull, significantly reducing the computational complexity compared to existing technologies.

[0042] Optionally, the method also includes the step of establishing the standard template library, including: simulating the electric field intensity distribution within the standard head three-dimensional model according to each electrode element attachment scheme on the standard head three-dimensional model; and determining the optimal treatment area corresponding to the electrode element attachment scheme according to the electric field intensity distribution.

[0043] For example, an area with an electric field strength greater than a set threshold is selected as the optimal treatment area. The optimal treatment area can be an entire area or divided into multiple areas.

[0044] In some embodiments, the tumor electric field treatment device is equipped with two pairs of electrode elements. The optimal treatment area can then be determined by comprehensively analyzing the electric field distribution generated by each pair of electrode elements.

[0045] After the electrode attachment plan is determined, a report can be output to instruct medical personnel on how to attach the electrode elements.

[0046] In some embodiments, the method further includes: generating a 3D printing file based on the three-dimensional head model of the target user and the attachment area of ​​the electrode element on the three-dimensional head model of the target user, the 3D printing file being used to make a carrier in the electrode wearing device corresponding to the target user, the carrier being used to carry the electrode element, and the area where the electrode element on the carrier is located facing the attachment area of ​​the target user.

[0047] refer to Figure 4 The electrode configuration device comprises a carrier 1, to which an electrode element 2 is fixed. Carrier 1 is provided with positioning points 3 for determining the device's placement on the target user's head. The center positioning point 3 coincides with the target user's eyebrows, and the two side positioning points 3 are located above the tops of the target user's ears. The target user can achieve optimal therapeutic effects by wearing the electrode device themselves.

[0048] In some embodiments, determining a three-dimensional head model of a target user and a target treatment area in the three-dimensional head model includes: obtaining a magnetic resonance image (MRI) of the target user's head, identifying a tumor area in the magnetic resonance image, and providing the identified tumor area to a reviewer for the reviewer to confirm the tumor area; establishing a three-dimensional head model of the target user based on the magnetic resonance image of the target user's head and the tumor area therein, and determining the tumor area in the three-dimensional head model of the target user.

[0049] The examiner is, for example, a medical staff. Since the method has the steps of constructing a three-dimensional head model of the target user and the target treatment area, the examiner has the opportunity to participate in the electrode attachment position determination method.

[0050] refer to Figure 5An embodiment of the present disclosure also provides an electrode attachment position determination device, comprising: at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the aforementioned electrode attachment position determination method.

[0051] An embodiment of the present disclosure further provides a computer-readable storage medium storing a program. When the program is executed by a processor, the processor executes the aforementioned electrode attachment position determination method.

[0052] Each embodiment of this disclosure is described in a progressive manner. Similar portions between embodiments can be referenced to each other. Each embodiment focuses on the differences from other embodiments. The descriptions of the device and computer-readable storage medium embodiments are simplified because they are generally similar to the method embodiments. For relevant portions, reference can be made to the descriptions of the method embodiments.

[0053] The device and computer-readable storage medium provided in the embodiments of the present disclosure correspond one-to-one to the method. Therefore, the device and computer-readable storage medium also have similar beneficial technical effects to their corresponding methods. Since the beneficial technical effects of the method have been described in detail above, the beneficial technical effects of the device and computer-readable storage medium will not be repeated here.

[0054] Those skilled in the art will appreciate that embodiments of the present disclosure may be provided as methods, systems, or computer program products. Therefore, the present disclosure may take the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Furthermore, the present disclosure may take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to magnetic disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0055] The present disclosure is described with reference to the flowcharts and / or block diagrams of the methods, apparatuses, and computer program products according to the embodiments of the present disclosure. It should be understood that each process and / or block in the flowchart and / or block diagram, as well as the combination of processes and / or blocks in the flowchart and / or block diagram, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing device to produce a machine, so that the instructions executed by the processor of the computer or other programmable data processing device generate instructions for implementing the processes in the flowchart and / or block diagram. Figure 1 a process or multiple processes and / or boxes Figure 1 A device that provides the functions specified in a block or multiple blocks.

[0056] These computer program instructions may also be stored in a computer readable memory that can direct a computer or other programmable data processing device to work in a specific manner, so that the instructions stored in the computer readable memory produce an article of manufacture comprising an instruction device, which implements the process Figure 1 a process or multiple processes and / or boxes Figure 1 The function specified in one or more boxes.

[0057] These computer program instructions can also be loaded onto a computer or other programmable data processing device so that a series of operational steps are executed on the computer or other programmable device to produce a computer-implemented process, thereby providing the instructions executed on the computer or other programmable device for implementing the process. Figure 1 a process or multiple processes and / or boxes Figure 1 A step that specifies a function in one or more boxes.

[0058] In a typical configuration, a computing device includes one or more processors (CPUs), input / output interfaces, network interfaces, and memory.

[0059] Memory may include non-permanent storage in a computer-readable medium, random access memory (RAM) and / or non-volatile memory in the form of read-only memory (ROM) or flash RAM. Memory is an example of a computer-readable medium.

[0060] Computer-readable media include permanent and non-permanent, removable and non-removable media that can be used to store information by any method or technology. The information can be computer-readable instructions, data structures, program modules, or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disc read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or any other non-transmission media that can be used to store information that can be accessed by a computing device. In addition, although the operations of the disclosed method are described in a specific order in the accompanying drawings, this does not require or imply that these operations must be performed in this specific order, or that all shown operations must be performed to achieve the desired result. Additionally or alternatively, certain steps can be omitted, multiple steps can be combined into one step, and / or one step can be decomposed into multiple steps.

[0061] Although the spirit and principles of the present disclosure have been described with reference to several specific embodiments, it should be understood that the present disclosure is not limited to the specific embodiments disclosed, and the division into various aspects does not mean that the features in these aspects cannot be combined to benefit. Such division is only for the convenience of expression. The present disclosure is intended to cover various modifications and equivalent arrangements included in the spirit and scope of the appended claims.

Claims

1. A method for determining an electrode attachment position, characterized in that: include: determining a three-dimensional head model of a target user and a target treatment area in the three-dimensional head model of the target user; Determining resizing parameters so that the target user's three-dimensional head model, obtained after resizing according to the resizing parameters, matches the standard three-dimensional head model, and resizing the target treatment area according to the determined resizing parameters; the resizing parameters refer to a scale factor, direction, and center point of stretching or compression, and the resizing parameters are determined when the corresponding point of the target user's three-dimensional head model partially or completely overlaps with the transformation reference point; Determining a degree of match between the target treatment area after the size transformation and an optimal treatment area corresponding to an electrode attachment scheme available in a standard template library, wherein the standard template library pre-stores a correspondence between electrode element attachment schemes and optimal treatment areas, and the electrode attachment scheme indicates an attachment area of ​​the electrode element in the standard three-dimensional head model; The attachment area determined by an available electrode attachment solution with the highest matching degree is subjected to an inverse transformation of the size transformation to obtain the attachment area of ​​the electrode element on the three-dimensional head model of the target user.

2. The method according to claim 1, characterized in that The target treatment area is a tumor area, and the electrode element is used to apply an alternating electric field to the tumor area.

3. The method according to claim 1, characterized in that In the case that the target user's head and scalp are intact, all electrode attachment schemes in the standard template library are available.

4. The method according to claim 1, wherein In the case where the target user's head or scalp has an avoidance area, the target treatment area and the avoidance area will be resized according to the determined size transformation parameters, and the attachment area of ​​the electrode element indicated by the electrode attachment scheme available in the standard template library in the standard head three-dimensional model does not overlap with the avoidance area after size transformation.

5. The method according to claim 1, wherein Performing an inverse transformation of the size transformation on the attachment area determined by an available electrode attachment solution with the highest matching degree to obtain the attachment area of ​​the electrode element on the three-dimensional head model includes: The attachment area determined by an available electrode attachment solution with the highest matching degree is subjected to an inverse transformation of the size transformation, and the orientation of the electrode element after the inverse transformation is used as the attachment orientation of the electrode element on the three-dimensional head model.

6. The method according to claim 1, wherein The method further comprises the step of establishing the standard template library, comprising: Simulating the electric field intensity distribution in the standard head three-dimensional model according to each electrode element attachment scheme on the standard head three-dimensional model; An optimal treatment area corresponding to the electrode element attachment scheme is determined according to the electric field intensity distribution.

7. The method according to claim 1, characterized in that The method also includes: generating a 3D printing file based on the three-dimensional head model of the target user and the attachment area of ​​the electrode element on the three-dimensional head model, the 3D printing file being used to produce a carrier in the electrode wearing device corresponding to the target user, the carrier being used to carry the electrode element, and the area where the electrode element on the carrier is located facing the attachment area of ​​the target user.

8. The method according to claim 1, characterized in that Determining a three-dimensional head model of a target user and a target treatment area in the three-dimensional head model includes: Acquiring a magnetic resonance image of the target user's head, identifying a tumor region in the magnetic resonance image, and providing the identified tumor region to a reviewer for confirmation by the reviewer; A three-dimensional head model of the target user is established according to the magnetic resonance image of the target user's head.

9. The method according to claim 1, characterized in that The electrode attachment plan indicates the attachment areas of all electrode elements in the standard three-dimensional head model.

10. An electrode attachment position determination device, characterized in that: include: at least one processor; and a memory communicatively connected to at least one processor; wherein the memory stores instructions executable by at least one processor, and the instructions are executed by at least one processor to enable the at least one processor to perform the method according to any one of claims 1 to 9.

11. A computer-readable storage medium, characterized in that The computer-readable storage medium stores a program, and when the program is executed by a processor, causes the processor to perform the method according to any one of claims 1 to 9.

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