Sweat sensor

Abstract

The present disclosure provides a sweat sensor, comprising: a sweat collection unit, the sweat collection unit contacts the body surface, and is suitable for in-situ collection and storage of sweat on the body surface; a signal acquisition unit, the signal acquisition unit is connected to the sweat collection unit, and is suitable for detecting a sufficient amount of sweat stored in the sweat collection unit; and a sweat control unit, which is arranged between the sweat collection unit and the signal acquisition unit, and is suitable for controlling the sufficient amount of sweat stored in the sweat collection unit, so that the components to be detected in the sufficient amount of sweat react fully with the signal acquisition unit. The sweat sensor of the embodiment of the present invention collects sweat and stores it until it is sufficient before detection, so that the reaction required for detection occurs fully, and it is avoided that insufficient sweat starts detection too early, resulting in insufficient reaction and failure to obtain accurate detection results.

Description

Technical Field

[0001] The present invention relates to the technical field of sensors, and in particular to a sweat sensor. Background Art

[0002] Wearable sensing technology can continuously monitor an individual's health status and is essential for achieving personalized medicine. Sensors combined with wearable sensing technology can monitor analytes in sweat in a non-invasive manner, thereby dynamically monitoring an individual's physiological health status. Human sweat is rich in a large number of potential markers related to health and disease. Compared with conventional blood and urine tests, it has the advantages of non-invasiveness and real-time continuous monitoring. Therefore, the research on in-situ sweat sensors has become an important branch of the development of wearable health electronic devices.

[0003] The continuous measurement of biomarkers in secreted sweat, such as electrolytes, metabolites, and proteins, using in situ sweat sensors is a promising research direction. However, due to the instability of sweat secretion and the low concentration of substances such as secreted sweat proteins, a large number of comparative studies are needed to directly correlate the concentrations of biomarkers based on sweat and gold standard plasma.

[0004] The successful commercialization of in situ sweat sensors requires maintaining the stability of the analytes detected during long-term and continuous exposure to sweat, and ensuring the stability of target disease-specific analytes, such as metabolites, proteins, etc., in complex sweat buffers. Over time, the pH and activity of target disease-specific analytes will also change. In addition, due to the relatively low concentration of small molecule metabolites (hormones, amino acids, peptides) in sweat, and the extremely low concentration of sweat secretion of small molecular weight proteins, protein biomarker analysis from a single sweat sample requires the collection and storage of the sweat to be tested until it meets the required amount for detection. Summary of the invention

[0005] Based on at least one of the above-mentioned and other technical problems in the prior art, the present invention provides a sweat sensor that collects sweat and stores a sufficient amount before testing, so that the required reaction during testing can fully occur, thereby improving the detection accuracy.

[0006] An embodiment of the present invention provides a sweat sensor, comprising: a sweat collecting unit, which contacts a body surface and is suitable for in-situ collection and storage of sweat on the body surface; a signal acquisition unit, which is connected to the sweat collecting unit and is suitable for detecting a sufficient amount of sweat stored in the sweat collecting unit; and a sweat control unit, which is arranged between the sweat collecting unit and the signal acquisition unit and is suitable for controlling the sufficient amount of sweat stored in the sweat collecting unit so that the components to be detected in the sufficient amount of sweat fully react with the signal acquisition unit.

[0007] In one possible implementation, the sweat control unit includes: a water-soluble layer configured to block the sweat from directly reacting with the signal acquisition unit until a sufficient amount of sweat dissolves the water-soluble layer.

[0008] In one possible implementation, the sweat collection unit includes: a first gel layer, one side of the first gel layer contacts the body surface, and the other side is connected to the signal acquisition unit, a through hole is provided in the thickness direction of the first gel layer, the through hole and the signal acquisition unit form a groove, and the groove is suitable for storing the sweat to a sufficient amount.

[0009] In one possible implementation, the first gel layer includes: an excretion promoter suitable for promoting the excretion of sweat; and conductive ions, so that the first gel layer has conductivity.

[0010] In one possible implementation, the signal acquisition unit includes: a flexible substrate having an inner side facing the body surface; a first electrode disposed on the inner side of the flexible substrate, and after the first electrode is electrically connected to the sufficient amount of sweat, it fully reacts with the component to be detected in the sufficient amount of sweat to produce a potential change; a second electrode disposed on the inner side of the flexible substrate, electrically connected to the sweat, and providing a standard potential for comparison with the potential change of the first electrode; a third electrode disposed on the inner side of the flexible substrate, and the third electrode is electrically connected to the sweat; after the first electrode is electrically connected to the sufficient amount of sweat, the first electrode is electrically connected to the third electrode to form a detection circuit.

[0011] In a possible implementation, the surface of the first electrode has a detection modification layer corresponding to the component to be detected in sweat, and the detection modification layer fully reacts with the component to be detected in the sufficient amount of sweat.

[0012] In a possible implementation, the outer surface of the detection modification layer is covered with a second gel layer, and the second gel layer is used to protect the stability of the detection function of the detection modification layer.

[0013] In one possible implementation, the second gel layer includes room temperature ions.

[0014] In a possible implementation, the detection modification layer is distributed discontinuously and includes modifications that can react with multiple components to be detected in the sweat simultaneously.

[0015] In a possible implementation, the third electrode is electrically connected to the sweat collecting unit, and the third electrode can electrically stimulate the body surface contacted by the sweat collecting unit to accelerate perspiration.

[0016] According to the sweat sensor of the above embodiment of the present invention, sweat is collected and stored until a sufficient amount is detected, so that the reaction required for the detection occurs fully, avoiding premature detection of insufficient sweat, resulting in insufficient reaction and inability to obtain accurate detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a top view of a sweat sensor according to an embodiment of the present invention;

[0018] Figure 2 for Figure 1 A cross-sectional view of the sweat sensor along line AA shown; and

[0019] Figure 3 FIG. 4 is a side cross-sectional view of a first electrode according to an embodiment of the present invention.

[0020] [Description of symbols in the accompanying drawings]

[0021] 1-body surface;

[0022] 2- Sweat collection unit;

[0023] 21- diversion trough;

[0024] 3- Sweat control unit;

[0025] 4-Signal acquisition unit;

[0026] 41- flexible substrate;

[0027] 42- a first electrode;

[0028] 421-detection modification layer;

[0029] 422 - second gel layer;

[0030] 43- second electrode;

[0031] 44- a third electrode;

[0032] 45-insulating part;

[0033] 5-Flexible circuit;

[0034] 6- flow guide;

[0035] 7-Liquid storage part. DETAILED DESCRIPTION

[0036] The invention discloses a sweat sensor, which collects sweat to be tested and stores it until a sufficient amount is reached before testing, so that a reaction required for testing occurs fully, thereby improving the testing accuracy.

[0037] Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. However, it should be understood that these descriptions are exemplary only and are not intended to limit the scope of the present disclosure. In the following detailed description, for ease of explanation, many specific details are set forth to provide a comprehensive understanding of the embodiments of the present disclosure. However, it is apparent that one or more embodiments may also be implemented without these specific details. In addition, in the following description, descriptions of known structures and technologies are omitted to avoid unnecessary confusion of the concepts of the present disclosure.

[0038] The terms used herein are only for describing specific embodiments and are not intended to limit the present disclosure. The terms "comprise", "include", etc. used herein indicate the existence of the features, steps, operations and / or components, but do not exclude the existence or addition of one or more other features, steps, operations or components.

[0039] All terms (including technical and scientific terms) used herein have the meanings commonly understood by those skilled in the art, unless otherwise defined. It should be noted that the terms used herein should be interpreted as having a meaning consistent with the context of this specification, and should not be interpreted in an idealized or overly rigid manner.

[0040] According to the overall inventive concept of the present disclosure, there is provided a sweat sensor, comprising: a sweat collecting unit, the sweat collecting unit contacts a body surface and is suitable for in-situ collection and storage of sweat on the body surface; a signal acquisition unit, the signal acquisition unit is connected to the sweat collecting unit and is suitable for detecting a sufficient amount of sweat stored in the sweat collecting unit; and a sweat control unit, arranged between the sweat collecting unit and the signal acquisition unit, and is suitable for controlling the sufficient amount of sweat stored in the sweat collecting unit so that a component to be detected in the sufficient amount of sweat fully reacts with the signal acquisition unit.

[0041] Figure 1 FIG. 4 is a top view of a sweat sensor according to an embodiment of the present invention.

[0042] like Figure 1 As shown, in one embodiment, the sweat sensor is electrically connected to the flexible circuit 5, and the flexible circuit 5 stimulates the body surface 1 through sweat sensing to promote the accelerated discharge of sweat from the body surface 1. The flexible circuit 5 also receives the detection signal collected by the sweat sensor and analyzes the detection signal to obtain detection data. In some embodiments, the flexible circuit 5 includes a wireless transmission device, which can send the detection data to a terminal device, such as a computer, a mobile phone, etc. in real time.

[0043] Figure 2 for Figure 1 A cross-sectional view of the sweat sensor along line AA is shown.

[0044] like Figure 2As shown, the sweat sensor of the embodiment of the present invention includes: a sweat collecting unit 2, which is in contact with the body surface 1 and is suitable for in-situ collection and storage of sweat on the body surface 1; a signal acquisition unit 4, which is connected to the sweat collecting unit 2 and is suitable for detecting a sufficient amount of sweat stored in the sweat collecting unit 2; and a sweat control unit 3, which is arranged between the sweat collecting unit 2 and the signal acquisition unit 4 and is suitable for controlling the sufficient amount of sweat stored in the sweat collecting unit 2 so that the components to be detected in the sufficient amount of sweat fully react with the signal acquisition unit 4.

[0045] In some embodiments of the present invention, the sweat control unit 3 includes: a water-soluble layer, which is configured to block sweat from directly reacting with the signal acquisition unit 4 until a sufficient amount of sweat dissolves the water-soluble layer. In some embodiments, the water-soluble layer is made of a membrane material that is gradually soluble in water, and the water-soluble layer can be designed according to the amount of sweat required for detection. When the water-soluble layer is not dissolved, it continues to block sweat from directly contacting and reacting with the signal acquisition unit 4. During the dissolution of the water-soluble layer, sweat gradually accumulates to a sufficient amount. The amount of the substance to be tested in the sufficient amount of sweat is large and can meet the detection requirements. After a sufficient amount of sweat dissolves the water-soluble layer, the sweat contacts the signal acquisition unit 4 and reacts fully to generate an electrochemical or optical signal as a detection signal.

[0046] In some embodiments of the present invention, a guide portion 6 and a liquid storage portion 7 connected to the guide portion 6 are further provided between the sweat collection unit 2 and the sweat control unit 3. In some embodiments, one end of the guide portion 6 is provided between the water-soluble layer and the flexible substrate 41, and after the water-soluble layer is dissolved, the excess sweat is guided out of the sweat collection unit 2 by capillary action. The other end of the guide portion 6 is connected to the liquid storage portion 7, and the liquid storage portion 7 stores the excess sweat guided out by the guide portion 6. In some embodiments, the surface of the guide portion 6 is modified with micrometer patterns and grooves, so that it has a capillary hydrophilic effect, which is conducive to sweat diversion.

[0047] In some embodiments of the present invention, the sweat collection unit 2 includes: a first gel layer, one side of the first gel layer contacts the body surface 1, and the other side is connected to the signal acquisition unit 4, a through hole is provided in the thickness direction of the first gel layer, the through hole and the signal acquisition unit 4 form a groove, and the groove is suitable for storing sweat to a sufficient amount.

[0048] In some embodiments of the present invention, the first gel layer comprises: an excretion promoter to promote the excretion of sweat; and conductive ions to make the first gel layer conductive. In some embodiments, the first gel layer is electrically connected to the flexible circuit 5. The flexible circuit 5 applies an electric current to the first gel layer, and the electric current drives the excretion promoter to penetrate into the skin on the body surface, stimulates the subcutaneous sweat glands to accelerate the secretion of sweat, and speeds up the in-situ collection speed of the sweat collection unit 2 for the sweat on the body surface 1, so that the sweat is accelerated to accumulate to a sufficient amount.

[0049] In some embodiments of the present invention, the excretion promoting agent is a drug that can induce sweat secretion, such as pilocarpine and acetylcholine.

[0050] In some embodiments of the present invention, the conductive ions may be ionic liquids, such as room temperature ionic liquids, so that the water in the first gel layer is not easily lost, thereby enabling the sweat sensor to be worn for a long time.

[0051] In some embodiments of the present invention, the surface of the first gel layer in contact with sweat is designed as a curved surface, which is conducive to the flow of sweat into the sweat collecting unit 2.

[0052] In some embodiments of the present invention, the surface of the first gel layer in contact with sweat has a guide groove 21, and the guide groove 21 guides the sweat discharged from the body surface 1 to flow into the sweat collection unit 2. The guide groove 21 can be directly prepared on the surface of the first gel layer in contact with sweat, or can be realized by placing a thin layer of plastic or a guiding polymer pattern on the surface of the first gel layer in contact with sweat.

[0053] Continue to refer Figure 2 As shown, in some embodiments, the signal acquisition unit 4 includes: a flexible substrate 41, having an inner side facing the body surface 1; a first electrode 42, arranged on the inner side of the flexible substrate 41, after the first electrode 42 is electrically connected to a sufficient amount of sweat, it fully reacts with the component to be detected in the sufficient amount of sweat to produce a potential change; a second electrode 43, arranged on the inner side of the flexible substrate 41, electrically connected to the sweat, and providing a standard potential for comparison with the potential change of the first electrode 42; a third electrode 44, arranged on the inner side of the flexible substrate 41, the third electrode 44 is electrically connected to the sweat; when the first electrode 42 is electrically connected to the sufficient amount of sweat, the first electrode 42 is electrically connected to the third electrode 44 to form a detection circuit.

[0054] In some embodiments of the present invention, the material of the flexible substrate 41 has a certain degree of flexibility, is bendable, can withstand the high temperature generated when preparing the first electrode 42, the second electrode 43 and the third electrode 44, and can be cut and processed. In some embodiments, the material of the flexible substrate 41 can be polyimide (PI), polydimethylsiloxane (PDMS), plastic thin layer material polyethylene terephthalate (PET), polycarbonate (PC), etc.

[0055] In some embodiments of the present invention, when the substance to be tested is detected, the first electrode 42 is a working electrode, the second electrode 43 is a reference electrode, and the third electrode 44 is a counter electrode. Sufficient sweat dissolves the sweat control unit 3, so that the sufficient sweat is connected to the first electrode 42 and the second electrode 43 at the same time, forming a detection circuit. An insulating portion 45 is provided between the first electrode 42 and the second electrode 43, and the second electrode 43 does not react with the substance to be tested and does not change its position. In some embodiments, the first electrode 42, the second electrode 43, and the third electrode 44 can all be prepared by sputtering or evaporation of a material with stable properties, such as precious metals such as gold and platinum and stable non-metals, and can also be prepared by printing with carbon paste.

[0056] Continue to refer Figure 2 As shown, in some embodiments, the surface of the first electrode 42 has a detection modification layer 421 corresponding to the component to be detected in sweat, and the detection modification layer 421 fully reacts with the component to be detected in a sufficient amount of sweat.

[0057] In some embodiments of the present invention, the detection modification layer 421 is a biological modification layer, which is a fixed layer of biological substances that can specifically identify the substances to be tested in sweat. The biological modification layer can use antibodies or aptamers that specifically recognize the substances to be tested and steroid hormones. In some embodiments, the biological modification layer can specifically recognize proteins to be tested in sweat, such as microalbumin (MA), interleukin 6 (IL-6), retinol-binding protein (RBP) and cortisol (COR). During detection, the protein to be detected in the sweat binds to the corresponding aptamer or antibody on the surface of the first electrode 42, causing the impedance of the first electrode surface to change. The impedance change triggers the flexible circuit 5 to collect the impedance change signal. The flexible circuit 5 performs electrochemical impedance spectroscopy (EIS) detection on the signal. The impedance value of the first electrode surface measured before the reaction is the baseline step impedance value. The difference between the baseline step impedance value and the first electrode surface impedance value measured after the reaction is the total impedance change rate (zmod). The concentration data of the protein to be detected in sweat can be obtained through the total impedance change rate (zmod). In other embodiments, the detection modification layer 421 can also be other biosensitive active substances, which respond to the active ingredients in sweat to achieve the detection of the substance to be detected in sweat, and is not limited to the recognition of proteins in sweat.

[0058] In some embodiments of the present invention, the detection modification layer 421 is intermittently distributed and includes a modifier that can react with multiple sweat components to be detected at the same time. In some embodiments, the detection modification layer 421 is intermittently distributed in strips or dot arrays, and different strips or dot arrays are modified with different biosensitive active substances to achieve simultaneous detection of multiple substances to be detected.

[0059] Figure 3 FIG. 4 is a side cross-sectional view of a first electrode according to an embodiment of the present invention.

[0060] like Figure 3 As shown, in some embodiments of the present invention, the outer surface of the detection modification layer 421 is covered with a second gel layer 422 , and the second gel layer 422 is used to protect the stability of the detection function of the detection modification layer 421 .

[0061] In some embodiments of the present invention, the second gel layer 422 includes room temperature ions. Room temperature ions can protect the biological stability of the detection modification layer 421. In some embodiments, the room temperature ions are contained in room temperature ionic liquids (IL) or room temperature ionic gels. Since the collection, storage and detection time of sweat is long, room temperature ionic liquids and room temperature ionic gels can effectively improve the activity and stability of biological sensitive active substances at room temperature for a long time. The room temperature ionic liquids that can be selected include: 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid, N,N-neopentyl glycol (N-methylimidazolium) bromide ionic liquid, 1-vinyl-3-ethylimidazolium hexafluorophosphate ionic liquid, 1-aminopropyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide ionic liquid, 1-sulfonic acid butyl-2-methyl-3-hexadecylimidazolium hydrogen sulfate ionic liquid, 1-butyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid, 1-butyl-3-methylimidazolium dicyanamide ionic liquid, 1-allyl-3-methylimidazolium chloride ionic liquid, 1-ethyl-2,3-dimethylimidazolium tetrafluoroborate ionic liquid, etc. Room temperature ionic liquid gel is formed by cross-linking ionic liquids. High ionic conductivity gel can be prepared by using 1-ethyl-trimethylimidazolium bis(trifluoromethanesulfonyl) chemical cross-linking vinyl monomers and other methods, and porous ionic liquid hydrogel can be prepared by inorganic salt-induced ionic liquids. The gel makes the sweat sensor easy to store and carry, maintains the activity of biological substances on the sweat sensor, and prevents the volatilization of sweat.

[0062] In some embodiments of the present invention, a nano-modification layer is further provided between the first electrode 42 and the detection modification layer 421, which can improve the sensitivity of the first electrode 42. In some embodiments, the nano-modification layer can be used to modify the first electrode 42 using gold nanoparticles or deposited platinum black nanoparticles, or can be used to modify the first electrode 42 using carbon nanotubes.

[0063] In some embodiments of the present invention, the surface of the second electrode 43 is modified with Ag / AgCl to ensure the stability of the standard potential provided by the second electrode during detection. Ag / AgCl can be prepared by printing with commercially available Ag / AgCl paste, or the silver layer can be modified first and then the surface of the silver layer is chlorinated to form an Ag / AgCl layer.

[0064] Continue to refer Figure 2 As shown, in some embodiments of the present invention, the third electrode 44 is electrically connected to the sweat collecting unit 2, and the third electrode 44 can electrically stimulate the body surface 1 contacted by the sweat collecting unit 2 to accelerate perspiration.

[0065] In some embodiments of the present invention, the third electrode 44 is connected to the first gel layer of the flexible circuit 5 and the sweat collection unit 2. Before the detection of the substance to be tested begins, the flexible circuit 5 electrically stimulates the body surface 1 through the third electrode 44 and the first gel layer to promote the discharge of sweat. In some embodiments, the flexible circuit 5 promotes the introduction of the excretion-promoting agent into the skin of the body surface 1 through the pores through the third electrode 44, induces the secretion of sweat, and further accelerates the discharge of sweat.

[0066] According to an embodiment of the present invention, the method for preparing a sweat sensor may specifically include steps S1-S12.

[0067] In step S1, a flexible substrate 41, a first electrode 42, a second electrode 43 and a third electrode 44 are prepared. Specifically, a 100-300 micron thick polyimide PI material is used as the material of the flexible substrate 41, and a 100-300 nanometer thick electrode is formed on the substrate by MEMS sputtering or evaporation process.

[0068] In step S2, a silver layer with a thickness of 100-300 nm is plated on the third electrode 44, and then the silver layer is chlorinated with FeCl3. Specifically, a 0.1M FeCl3 solution is injected on the evaporated Ag electrode for 1 minute to form an Ag / AgCl layer.

[0069] In step S3, a nano-modified layer is modified on the surface of the first electrode 42. Specifically, 40-60 nm gold nanoparticles are modified on the surface of the first electrode 42 to form a nano-modified layer.

[0070] In step S4, the biomodification layer is modified on the nanomodification layer. Specifically, the gold nanoparticles are functionalized with thiol groups by carbodiimide hydrochloride / N-hydroxysuccinimide (EDC / NHS), and the d-IL-6 aptamer of the biomaterial 100 μg / ml is diluted in 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid at room temperature, and then fixed on the surface of the first electrode 42 modified with the nanoparticles.

[0071] In step S4, the sweat control unit 3 is assembled. Specifically, a water-soluble layer with a thickness of 0.5 to 2 mm is attached around the first electrode 42 to completely cover the first electrode 42. After the guide part 6 is bonded to the liquid storage part 7, the other end of the guide part 6 is adhered to one side of the water-soluble layer.

[0072] In step S5, the sweat collection unit 2 and the third electrode 44 are connected. Specifically, the first gel layer is attached to the third electrode 44. Specifically, the first gel layer is prepared with 1-8% agar, 0.01-4% excretion promoter, and 1-butyl-3-methylimidazolium hexafluorophosphate ionic liquid.

[0073] According to the sweat sensor of the present invention, sweat is collected and stored until a sufficient amount is reached before detection. The content of the substance to be tested in the sufficient amount of sweat is relatively high, which satisfies the sufficient occurrence of the reaction required for the detection, thereby avoiding insufficient content of the substance to be tested at the beginning of the detection, resulting in insufficient reaction and inability to obtain accurate detection results.

[0074] The ordinal numbers used in the specification and claims, such as "first", "second", "third", etc., to modify the corresponding elements, do not themselves mean that the elements have any ordinal numbers, nor do they represent the order of one element and another element, or the order in the manufacturing method. The use of these ordinal numbers is only used to clearly distinguish a component with a certain name from another component with the same name.

[0075] The specific embodiments described above further illustrate the purpose, technical solutions and beneficial effects of the present disclosure. It should be understood that the above description is only a specific embodiment of the present disclosure and is not intended to limit the present disclosure. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present disclosure should be included in the protection scope of the present disclosure.

Claims

1. A sweat sensor, comprising: A sweat collection unit (2), the sweat collection unit (2) being in contact with the body surface (1) and being suitable for in-situ collection and storage of sweat on the body surface (1); a signal collection unit (4), the signal collection unit (4) being in communication with the sweat collection unit (2) and being adapted to detect a sufficient amount of sweat stored in the sweat collection unit (2); as well as A sweat control unit (3) is arranged between the sweat collection unit (2) and the signal collection unit (4), and is adapted to control a sufficient amount of sweat stored in the sweat collection unit (2) so that components to be detected in the sufficient amount of sweat react fully with the signal collection unit (4); Wherein, the signal acquisition unit (4) comprises: A flexible substrate (41) having an inner side facing the body surface (1); A first electrode (42) is arranged on the inner side of the flexible substrate (41); after the first electrode (42) is electrically connected to the sufficient amount of sweat, it fully reacts with the component to be detected in the sufficient amount of sweat to generate a potential change; a second electrode (43), arranged on the inner side of the flexible substrate (41), electrically connected to the sweat, and providing a standard potential for comparison with the potential change of the first electrode (42); a third electrode (44), arranged on the inner side of the flexible substrate (41), the third electrode (44) being electrically connected to the sweat; After the first electrode (42) is electrically connected to the sufficient amount of sweat, the first electrode (42) is electrically connected to the third electrode (44) to form a detection circuit; The surface of the first electrode (42) has a detection modification layer (421) corresponding to the component to be detected in the sweat, and the detection modification layer (421) fully reacts with the component to be detected in the sufficient amount of sweat; The outer surface of the detection modification layer (421) is covered with a second gel layer (422), and the second gel layer (422) is used to protect the stability of the detection function of the detection modification layer (421); Wherein, the second gel layer (422) includes room temperature ions; Wherein, the detection modification layer (421) is distributed intermittently and includes a modification material that can react with a plurality of components to be detected in the sweat at the same time; The third electrode (44) is electrically connected to the sweat collection unit (2), and the third electrode (44) can electrically stimulate the body surface (1) in contact with the sweat collection unit (2), thereby accelerating perspiration.

2. The sweat sensor according to claim 1, wherein: The sweat control unit (3) comprises: The water-soluble layer is configured to prevent the sweat from directly reacting with the signal acquisition unit (4) until a sufficient amount of sweat dissolves the water-soluble layer.

3. The sweat sensor according to claim 1, wherein: The sweat collection unit (2) comprises: A first gel layer, one side of the first gel layer contacts the body surface (1), and the other side is connected to the signal acquisition unit (4), a through hole is provided in the thickness direction of the first gel layer, the through hole and the signal acquisition unit (4) form a groove, and the groove is suitable for storing the sweat to a sufficient amount.

4. The sweat sensor according to claim 3, wherein: The first gel layer comprises: an excretion promoting agent, adapted to promote the excretion of the sweat; and Conductive ions make the first gel layer conductive.

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