A preheating treatment device suitable for glass slides

Abstract

The present invention discloses a preheating treatment device suitable for glass slides, comprising a main body and a plurality of heating tanks for placing the glass slides. The main body is provided with a plurality of recesses, each heating tank being configured to be movably embedded in each recess, and each recess being provided with a temperature regulating structure for heating or cooling the corresponding heating tank. The present invention can simultaneously perform good and stable preheating treatment on multiple glass slides, which is beneficial to improving the preheating treatment efficiency of the glass slides. Moreover, by movably embedding the heating tanks in the recesses of the main body, the heating tanks can be removed from or embedded in the main body as needed, which is beneficial to transferring the heating tanks and the glass slides therein together according to experimental requirements, thereby improving the convenience of the transfer operation of the glass slides.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical experimental equipment, and in particular to a preheating treatment device suitable for glass slides. Background Art

[0002] FISH (fluorescence in situ hybridization) is a method used in the biomedical field to inhibit the chromosome localization of genes or sequences, and it plays a significant role in the qualitative and quantitative integration and expression of genes. During the experiment, the slides carrying the samples need to be preheated in order to provide sufficient reaction temperature for each item of FISH pretreatment. Existing slide heating technologies mostly achieve slide preheating by laying them flat or in a louver style, or by tilting them on a drying rod. Although the flat-laying slide baking machine can heat the slides evenly, the thin glass slides themselves make it difficult to place and remove the slides, resulting in low efficiency. The louver and drying rod styles are not only difficult to place and inefficient, but are also prone to tilting the slides due to external vibrations when placed unstably, and the drying rod may also be heated unevenly. Summary of the Invention

[0003] In view of the shortcomings of the existing technology, the present invention provides a preheating treatment device suitable for glass slides. By arranging multiple heating slots on the main body, multiple carrier slides can be preheated stably and evenly at the same time, thereby improving the efficiency of the preheating treatment of the glass slides.

[0004] To achieve the above object, the present invention is achieved through the following technical solutions:

[0005] A preheating treatment device suitable for glass slides includes a main body and several heating tanks for placing glass slides. The main body is provided with several recesses. Each heating tank is configured to be able to be movably embedded in each recess in an adaptive manner. Each recess is provided with a temperature regulating structure for heating or cooling the corresponding heating tank.

[0006] Furthermore, the heating tank is configured to hold water so as to perform a water bath insulation treatment on the glass slide placed in the heating tank at a preset temperature.

[0007] Furthermore, a plurality of side ribs for fixing the glass slide are arranged around the side walls of the heating tank, and a plurality of raising protrusions for raising the glass slide are arranged on the bottom surface of the heating tank.

[0008] Furthermore, avoidance spaces are formed on both sides of the heating tank to facilitate taking and placing slides in the heating tank.

[0009] Furthermore, lifting ears are provided on both sides of the heating tank to facilitate taking the heating tank out of the recess of the main body.

[0010] Furthermore, the main body includes a shell, in which a radiator is provided, and a plurality of heat conduction adapters are connected to the back of the radiator, each heat conduction adapter is stacked with a thermal insulation pad, a first window is opened in the thermal insulation pad, a Peltier element is embedded in the first window, the bottom of the Peltier element is in close contact with the heat conduction adapter, a heating block is stacked on each thermal insulation pad, the top of the Peltier element is in close contact with the bottom of the heating block, and a receiving groove is formed on the heating block that is adapted to the shape of the heating tank to form a recess for movably embedding the heating tank. The radiator, the heat conduction adapter, the thermal insulation pad, the Peltier element and the heating block cooperate with each other to form a temperature regulation structure for heating or cooling the corresponding heating tank.

[0011] Furthermore, the top of the thermal insulation pad is slightly higher than the top of the Peltier element, and a downwardly extending protrusion is formed on the bottom of the heating block. The size of the protrusion is adapted to the size of the first window of the thermal insulation pad, so that when the heating block is stacked and fixed on the thermal insulation pad, the protrusion on the bottom of the heating block can be adapted to be embedded in the first window of the thermal insulation pad and tightly attached to the top of the Peltier element.

[0012] Furthermore, a second window is provided on the thermal insulation pad, a temperature control switch element is embedded in the second window, and a temperature sensor used in conjunction with the temperature control switch element is embedded in the heating block.

[0013] Furthermore, the temperature sensor is a temperature sensor with a thermistor structure, and the thermal insulation pad is a thermal insulation pad made of EPDM foam rubber.

[0014] Furthermore, it also includes a heat insulation cover, which is arranged on the back of the radiator and has a plurality of openings corresponding to the accommodating grooves of each heating block. The top of the heat insulation cover is flush with the top of the heating groove embedded in the heating block.

[0015] The above technical solution has the following advantages or beneficial effects:

[0016] In the preheating treatment device suitable for glass slides described in the present invention, a plurality of recesses are provided on the main body, and each heating tank can be respectively adapted to be embedded in each recess, and each recess is correspondingly provided with a temperature regulating structure that can heat or cool the heating tank, thereby forming a plurality of preheating treatment stations on the main body, which can simultaneously perform good and stable preheating treatment on a plurality of glass slides, which is beneficial to improving the preheating treatment efficiency of the glass slides, and by movably embedding the heating tank in the recess of the main body, the heating tank can be removed from or embedded in the main body as needed, which is beneficial to transferring the heating tank and the glass slides inside it together according to experimental requirements, thereby improving the convenience of the transfer operation of the glass slides. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the three-dimensional structure of an embodiment of the present invention.

[0018] Figure 2 It is a schematic diagram of the partial structure behind the hidden heat shield of an embodiment of the present invention.

[0019] Figure 3 It is a schematic diagram of the partial structure decomposition behind the hidden heat shield of an embodiment of the present invention.

[0020] Figure 4 This is a schematic diagram of the partial structure exploded from another angle behind the hidden heat shield of an embodiment of the present invention.

[0021] Description of labels:

[0022] 1. Main body, 2. Heating tank, 11. Radiator, 12. Heat conduction adapter, 13. Thermal insulation pad, 14. Peltier element, 15. Heating block, 16. Temperature control switch element, 17. Temperature sensor, 18. Thermal shield, 21. Side ribs, 22. Raised protrusion, 23. Avoidance space, 24. Lifting ear, 131. First window, 132. Second window, 151. Accommodating groove, 152. Protrusion. DETAILED DESCRIPTION

[0023] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0024] In the description of the present invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as limiting the present invention.

[0025] Please refer to the attached Figure 1 To the attached Figure 4An embodiment of the present invention provides a preheating treatment device suitable for glass slides, which is installed in an automated glass slide processing system and includes a main body 1 and a plurality of heating tanks 2 for placing glass slides. The main body 1 is provided with a plurality of recesses, and each heating tank 2 is configured to be able to be movably embedded in each recess in an adaptive manner, and each recess is provided with a temperature regulating structure for heating or cooling the corresponding heating tank 2. It can also be understood that in this embodiment, the preheating treatment device can be directly installed in an automated slide processing system. During the FISH pretreatment process, the temperature of the corresponding heating tank 2 can be controlled by the temperature regulating structures in the preheating treatment device, and then the heating tank 2 movably embedded in the recesses of the main body is used to preheat and keep the slides placed in the heating tank 2 warm, so as to provide sufficient reaction temperature for each item of FISH pretreatment. In addition, a plurality of recesses are provided on the main body 1, and each heating tank 2 can be respectively adapted to be embedded in each recess. Each recess is correspondingly provided with a temperature regulating structure that can heat or cool the heating tank 2, thereby forming a plurality of preheating treatment stations on the main body 1, which can simultaneously perform good and stable preheating treatment on multiple slides, thereby improving the preheating treatment efficiency of the slides. In addition, by movably embedding the heating tank 2 in the recess of the main body 1, the heating tank 2 can be removed from the main body 1 or embedded as needed, which is conducive to transferring the heating tank 2 and the slides therein together according to the experimental requirements, thereby improving the convenience of the slide transfer operation.

[0026] In this embodiment, preferably, 3*4 heating stations, totaling 12, are provided on the main body 1, so that the preheating treatment device can preheat 12 glass slides at the same time. However, those skilled in the art should immediately understand that in other embodiments, other numbers of heating stations can also be provided on the main body 1, and are not limited to the specific implementation method disclosed in this embodiment.

[0027] Please refer to the attached Figure 1 To the attached Figure 2 In one preferred embodiment, the heating tank 2 is configured to hold water, so that the glass slides placed in the heating tank 2 are kept warm in a water bath at a preset temperature. It is understood that in this embodiment, the water bath heating method allows the glass slides placed in the heating tank 2 to be heated evenly and stably, eliminating the drawbacks of existing heating technologies such as difficulty in placing the glass slides and uneven heating.

[0028] Please refer to the attached Figure 3In one preferred embodiment, a plurality of side ribs 21 for fixing the glass slides are provided around the side walls of the heating tank 2, and a plurality of raised protrusions 22 for raising the glass slides are provided on the bottom surface of the heating tank 2. It can be understood that in this embodiment, the side ribs 21 can well fix the glass slides placed in the heating tank 2. At the same time, the raised protrusions 22 on the bottom surface of the heating tank 2 can, on the one hand, prevent the glass slides from directly contacting the bottom surface of the heating tank 2, thereby facilitating improved heating uniformity. On the other hand, the raised protrusions 22 can separate the glass slides from the bottom surface of the heating tank 2, which helps to reduce the difficulty of removing the glass slides from the heating tank 2.

[0029] Please refer to the attached Figure 3 In one preferred embodiment, escape spaces 23 are formed on both sides of the interior of the heating tank 2 to facilitate taking and placing glass slides in the heating tank 2. It is understandable that by forming the escape spaces 23 on both sides of the interior of the heating tank 2, when taking and placing the glass slides, the operator's fingers can be inserted into the escape spaces 23, and the glass slides in the heating tank 2 can be quickly and stably grasped, which is conducive to reducing the difficulty of taking and placing the glass slides in the heating tank 2 and improving its taking and placing efficiency.

[0030] Please refer to the attached Figure 3 In one preferred embodiment, the heating tank 2 is provided with lifting ears 24 on both sides thereof for facilitating the removal of the heating tank 2 from the recess of the main body 1. It is understood that by providing the lifting ears 24 on both sides of the heating tank 2, the heating tank 2 can be quickly and conveniently removed from or inserted into the recess of the main body 1, thereby improving the convenience of taking the heating tank 2 out and placing it, and also providing a certain degree of scalding protection.

[0031] In one of the preferred embodiments, during the FISH pretreatment process, the heating tank 2 can not only be used to preheat the slides, but also serve as an experimental site for certain experimental steps of the FISH pretreatment. The corresponding materials can be directly added or pumped into the heating tank 2 through external auxiliary equipment to conduct experiments, thereby helping to reduce the number of transfers of the preheated slides and improve operational efficiency.

[0032] Please refer to the attached Figure 1 To the attached Figure 4In one preferred embodiment, the main body 1 includes a shell, in which a heat sink 11 is provided. The back of the heat sink 11 is connected to a plurality of aluminum heat conduction adapters 12. A thermal insulation pad 13 is stacked on each heat conduction adapter 12. A first window 131 is opened in the thermal insulation pad 13. A Peltier element 14 (specific model is preferably THC1-19912) is embedded in the first window 131. The bottom of the Peltier element 14 is in close contact with the heat conduction adapter 12. An aluminum heating block 15 is stacked on each thermal insulation pad 13. The top of the Peltier element 14 is in close contact with the bottom of the heating block 15. The heating block 15 is formed with an accommodating groove 151 that is compatible with the shape of the heating tank 2 to form a recess for movably embedding the heating tank 2. The heat sink 11, the heat conduction adapter 12, the thermal insulation pad 13, the Peltier element 14 and the heating block 15 cooperate with each other to form a temperature regulation structure for heating or cooling the corresponding heating tank 2. It will be appreciated that, in this embodiment, the Peltier element 14 in the temperature regulation structure can produce a Peltier effect. When heating is required, the hot end of the Peltier element 14 can release heat as needed, thereby heating the heating block 15, thereby heating the heating tank 2 through heat conduction between the heating block 15 and the heating tank 2. Simultaneously, when cooling is required, the cold end of the Peltier element 14 can absorb heat as needed, which is then released through a heat sink connected to the heat conduction adapter 12, thereby cooling the heating block 15, thereby cooling the heating tank 2 through heat conduction between the heating block 15 and the heating tank 2. Furthermore, in this embodiment, the principles and implementation methods of the heating and cooling effects of the Peltier element 14 are common knowledge to those skilled in the art and will not be elaborated upon here.

[0033] Please refer to the attached Figure 2 To the attached Figure 4 In one preferred embodiment, the top of the thermal insulation pad 13 is slightly higher than the top of the Peltier element 14. The bottom of the heating block 15 is formed with a downwardly extending protrusion 152. The size of the protrusion 152 is adapted to the size of the first window 131 of the thermal insulation pad 13. When the heating block 15 is stacked and fixed on the thermal insulation pad 13, the protrusion 152 on the bottom of the heating block 15 can be adapted to be embedded in the first window 131 of the thermal insulation pad 13 and tightly abut against the top of the Peltier element 14. In this embodiment, the protrusion 152 is preferably located near the middle of the bottom of the heating block 15, so that the protrusion 152 in the middle position can tightly cooperate with the top of the Peltier element 14 to achieve heating or cooling of the middle section of the heating block 15.

[0034] Please refer to the attached Figure 3In one preferred embodiment, the thermal insulation pad 13 further includes a second window 132, embedded within which is a temperature-controlled switch element 16 (preferably a KSD9700). Furthermore, the heating block 15 includes a temperature sensor 17 (preferably a thermistor B3950, 10KΩ, 1%) embedded therein for use with the temperature-controlled switch element 16. It will be appreciated that the temperature sensor 17 provides real-time feedback on the temperature of the heating block 15. When the temperature reaches a predetermined level, the temperature-controlled switch element 16 controls the Peltier element 14 to stop heating.

[0035] Please refer to the attached Figure 3 In one preferred embodiment, the temperature sensor 17 is a temperature sensor with a thermistor structure, and the thermal insulation pad 13 is a thermal insulation pad made of EPDM foam rubber.

[0036] Please refer to the attached Figure 1 To the attached Figure 2 In one preferred embodiment, a heat shield 18 made of silicone material is further included. The heat shield 18 is positioned over the back of the radiator 11 and has a plurality of openings corresponding to the receiving recesses 151 of the heating blocks 15. The top of the heat shield 18 is flush with the top of the heating slots 2 embedded in the heating blocks 15. It is understood that the shielding effect of the heat shield 18 can reduce the impact of external air flow on the internal temperature.

[0037] The embodiments described above are only used to illustrate the technical solutions of the present invention, rather than to limit them. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. These modifications or replacements do not deviate from the spirit and scope of the technical solutions of the embodiments of the present invention. Therefore, all other embodiments obtained by those skilled in the art without making any creative work shall fall within the scope of protection of the present invention.

Claims

1. A preheating device for a glass slide, characterized in that: The device comprises a main body (1) and a plurality of heating tanks (2) for placing glass slides, wherein the main body (1) is provided with a plurality of recesses, each heating tank (2) is configured to be adaptively and movably embedded in each recess, and each recess is provided with a temperature regulating structure for heating or cooling the corresponding heating tank (2); A plurality of side ribs (21) for fixing the glass slide are provided around the side wall of the heating tank (2), and a plurality of raising protrusions (22) for raising the glass slide are provided on the bottom surface of the heating tank (2); Both sides of the interior of the heating tank (2) are formed with avoidance spaces (23) for facilitating the taking and placing of slides in the heating tank (2); The main body (1) includes a shell, a heat sink (11) is provided in the shell, a plurality of heat conduction adapters (12) are connected to the back of the heat sink (11), a heat insulation pad (13) is stacked on each heat conduction adapter (12), a first window (131) is opened in the heat insulation pad (13), a Peltier element (14) is embedded in the first window (131), the bottom of the Peltier element (14) is in close contact with the heat conduction adapter (12), and a heat insulation pad (13) is stacked on each heat insulation pad (13). The heating block (15) is provided with a top of the Peltier element (14) in close contact with the bottom of the heating block (15). The heating block (15) is provided with an accommodating groove (151) adapted to the outer shape of the heating tank (2) to form a recess for movably embedding the heating tank (2). The heat sink (11), the heat conduction adapter (12), the thermal insulation pad (13), the Peltier element (14) and the heating block (15) cooperate with each other to form a temperature regulating structure for heating or cooling the corresponding heating tank (2).

2. The preheating device for glass slides according to claim 1, characterized in that: The heating tank (2) is configured to hold water so as to perform a water bath insulation treatment on the glass slide placed in the heating tank (2) at a preset temperature.

3. The preheating treatment device for glass slides according to claim 2, characterized in that: Lifting ears (24) are provided on both sides of the heating tank (2) for facilitating removal of the heating tank (2) from the recess of the main body (1).

4. The preheating treatment device for slides according to claim 1, characterized in that: The top of the thermal insulation pad (13) is slightly higher than the top of the Peltier element (14), and the bottom of the heating block (15) is formed with a protrusion (152) protruding downward, and the size of the protrusion (152) is adapted to the size of the first window (131) of the thermal insulation pad (13), so that when the heating block (15) is stacked and fixed on the thermal insulation pad (13), the protrusion (152) on the bottom of the heating block (15) can be adapted to be embedded in the first window (131) of the thermal insulation pad (13) and tightly attached to the top of the Peltier element (14).

5. The preheating treatment device for slides according to claim 1, characterized in that: A second window (132) is further provided on the heat insulating pad (13), a temperature control switch element (16) is embedded in the second window (132), and a temperature sensor (17) used in conjunction with the temperature control switch element (16) is embedded in the heating block (15).

6. The preheating treatment device for glass slides according to claim 5, characterized in that: The temperature sensor (17) is a temperature sensor with a thermistor structure, and the thermal insulation pad (13) is a thermal insulation pad made of EPDM foam rubber.

7. The preheating treatment device for slides according to claim 1, characterized in that: The heat shield (18) is provided on the back of the radiator (11), and a plurality of openings are provided on the heat shield (18) that are respectively arranged to correspond to the receiving grooves (151) of each heating block (15). The top of the heat shield (18) is flush with the top of the heating groove (2) embedded in the heating block (15).

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