Extraction column placement device

Abstract

The present invention provides an extraction column placement device, which comprises a movable column frame, a sliding column pressure plate located above the movable column frame, a pull rod support plate fixed below the movable column frame, and a liquid adding column whose two ends are respectively fixed on the movable column frame and the pull rod support plate; a dripping plug is installed at the outlet end of the liquid adding column, the dripping plug has a linear gap that is kept sealed under normal conditions, and the dripping plug is also provided with a radial flange that can open the linear gap, and the lower side of the radial flange is in corresponding contact with the pull rod support plate; the inlet end of the liquid adding column is sealed and connected to the lower side of the sliding column pressure plate through a sealing element, and the sliding column pressure plate can controllably apply force downward to the inlet end of the liquid adding column, so that a relative movement trend is generated between the radial flange of the dripping plug at the outlet end of the liquid adding column and the pull rod support plate. The present application can quickly switch the sealing and flow states of the outlet ends of all liquid adding columns without cross contamination problems.

Description

Technical Field

[0001] The invention relates to an extraction column placement device capable of limiting the outflow of reagents, in particular to a simple, fast and convenient sample pre-treatment technology in laboratory applications. Background Art

[0002] Extraction is a unit operation that uses the difference in the distribution coefficient of the solvent between two immiscible phases to purify or concentrate them. Since the appropriate extractant and process can be selected according to the separation object and requirements, it has the characteristics of high selectivity, good separation effect and strong adaptability. Solvent extraction is usually carried out at room temperature or low temperature, with low energy consumption. It is particularly suitable for the separation of heat-sensitive substances and is easy to achieve large-scale continuous production. In recent years, extraction has been increasingly widely used in industrial processes such as atomic energy, hydrometallurgy, petroleum, chemical industry, medicine and environmental protection, as well as high-tech fields such as bioengineering and new materials. Extraction equipment has also been continuously developed and updated with the widespread application of extraction in industry.

[0003] Solid phase extraction is a sample pretreatment technology that has been developed since the mid-1980s. Solid phase extraction uses solid adsorbents to adsorb target compounds in liquid samples, separate them from the sample matrix and interfering compounds, and then elute with eluent or heat desorb to achieve the purpose of separating and enriching target compounds. Compared with traditional liquid-liquid extraction, solid phase extraction does not require a large amount of immiscible solvents, and no emulsification will occur during the treatment process. It can improve the recovery rate of analytes, significantly reduce the amount of solvents, simplify the sample treatment process, and reduce the cost. It reduces the sample pretreatment process, is simple to operate, saves time and effort. As a sample pretreatment technology, solid phase extraction has been increasingly widely used in laboratories, and is widely used in the fields of medicine, food, environment, commodity inspection, and chemical industry.

[0004] As a simple, fast and convenient sample pretreatment technology, it has only been invented for more than ten years. Due to its unique balance method and sampling ideas, it has attracted widespread attention from domestic and foreign scholars in recent years and has developed rapidly. This solid phase extraction column has various forms, and different applications and requirements. The existing 5ml solid column is easy to dry up during use, and it will leak during movement. The pipeline is messy, the number of solenoid valves is large, and the density of the solid adsorbent is different, which is easy to cause cross contamination during the extraction process. Summary of the invention

[0005] Therefore, an object of the present invention is to provide an extraction column placement device that can limit the outflow of reagents to solve at least one of the above-mentioned technical problems existing in the prior art.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] An extraction column placement device, characterized in that it comprises a movable column frame, a sliding column pressing plate located above the movable column frame, a pull rod supporting plate fixed below the movable column frame, and a liquid adding column with two ends respectively fixed to the movable column frame and the pull rod supporting plate;

[0008] The outlet end of the liquid adding column is provided with a dripping plug, the dripping plug having a linear gap which is kept sealed under normal conditions, and the dripping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is in corresponding contact with the pull rod support plate;

[0009] The inlet end of the liquid adding column is sealed and connected to the lower side of the slide column pressure plate through a sealing element. The slide column pressure plate can apply a controllable downward force to the inlet end of the liquid adding column, so that a relative movement tendency is generated between the radial flange of the drip plug at the outlet end of the liquid adding column and the pull rod support plate.

[0010] The extraction column placement device, wherein: the inlet end of the liquid-adding column is provided with a column adapter, the column adapter is cylindrical, and matches the shape of the inlet end of the liquid-adding column to form a sealed connection; a sliding plunger is sealedly connected to the column adapter, and the sliding plunger can form a sealed connection with the gun head.

[0011] The extraction column placement device, wherein: the drip plug has a tube body, one end of the tube body is open and can be sealed and sleeved on the outlet end of the liquid adding column, the other end of the tube body is integrally formed with a sealing sheet, and the linear gap is formed on the sealing sheet, and the radial flange is integrally formed on the relatively outer side of the tube body.

[0012] The extraction column placement device, wherein: the drip plug is made of silicone rubber.

[0013] The extraction column placement device, wherein: the drip plug has two radial flanges, and the two radial flanges are rectangular when viewed from above.

[0014] The extraction column placement device, wherein: a plurality of upper stepped holes are formed on the movable column frame, each of which can be used for the upper end of a liquid adding column to be inserted and fixed, and a plurality of lower stepped holes are formed on the pull rod support plate, each of which can be used for a drip plug sleeved on the outlet end of the liquid adding column to be inserted, and the two radial flanges of the drip plug are in contact with the step surface of the lower stepped hole.

[0015] The extraction column placement device, wherein: the sliding column pressure plate is connected to the movable column frame through a pressure plate screw.

[0016] The extraction column placement device, wherein: the sliding column pressure plate is provided with a bell mouth corresponding to the open end of each liquid adding column, and the open end of the liquid adding column, the column adapter, the sliding plunger and the lower surface of the bell mouth form a sealing connection in sequence.

[0017] The extraction column placement device, wherein: the movable column frame is provided with a plurality of upper countersunk holes from top to bottom, and the pull rod support plate is provided with a plurality of lower countersunk holes from bottom to top, and the upper screws inserted into the upper countersunk holes and the lower screws inserted into the lower countersunk holes are respectively connected to the two ends of a sliding column pull rod through threads, thereby connecting the movable column frame and the pull rod support plate together.

[0018] The extraction column placement device, wherein: a sliding column stopper is installed at each end of the movable column frame.

[0019] The advantages of the present invention are:

[0020] 1. The liquid-adding column of the present invention can solve the problems of easy drying of the small column during use, leakage during movement, messy pipelines, a large number of solenoid valves, different densities of solid adsorbents, and easy cross contamination during the extraction process.

[0021] 2. The movable column rack of the present invention is designed to facilitate smooth sliding under the action of external force and reduce friction. The two ends are designed to be as parallel as possible to the slide rod, so that the arc size is the same as the diameter of the slide rod to ensure a smooth sliding process. In addition, in order not to increase additional friction and facilitate installation, the contact surface between the movable column rack and the slide rod is minimized while ensuring a smooth sliding process. The lower end of the movable column rack except the contact surface is specially processed into a certain contraction angle as a guide during the installation process, and it slides into the equipment along the angle to facilitate better installation and reduce the corresponding friction. The material is acid-resistant PP material, which facilitates the rapid movement of the entire column rack in the equipment. This device is designed to adopt a floating installation method and can be installed without any tools. The purpose is to meet the requirements of simple operation and convenient replacement of the movable column rack 1, which can effectively avoid maintenance and greatly improve the sample processing efficiency.

[0022] 3. The present invention assembles multiple liquid-adding columns together, which greatly improves the sample processing efficiency, is simple to operate, convenient to replace, has high experimental accuracy, and reduces the labor intensity of experimenters. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a stereogram of the present invention.

[0024] Figure 2 It is a cross-sectional assembly diagram of the liquid adding column component of the present invention.

[0025] Figure 3 A diagram of a single 5 ml liquid addition column assembly of the present invention.

[0026] Figure 4 It is an assembly diagram of the pull rod of the present invention.

[0027] Figure 5 , Figure 6 They are respectively a longitudinal sectional view and a bottom view of the drip plug of the present invention.

[0028] Explanation of the reference numerals: 1-movable column frame; 2-sliding column block; 3-sliding column pull rod; 4-pull rod support plate; 5-upper screw; 6-lower screw; 7-liquid adding column; 8-column adapter; 9-sliding column plug; 10-sliding column pressure plate; 11-drip plug; 12-pressure plate screw; 13-sealing sheet; 14-linear gap; 15-radial flange; 16-step surface; 17-bell mouth. DETAILED DESCRIPTION

[0029] The present invention will be further described below in conjunction with the accompanying drawings and specific implementation methods.

[0030] The present invention provides an extraction column placement device capable of limiting the outflow of reagents, such as Figure 1 , Figure 2 , Figure 4 As shown, there is a movable column frame 1, a sliding column pressure plate 10 located above the movable column frame 1, a pull rod support plate 4 located below the movable column frame 1, a liquid adding column 7 with two ends respectively fixed on the movable column frame 1 and the pull rod support plate 4, and a sliding column pull rod 3 connecting the movable column frame 1 and the pull rod support plate 4.

[0031] Among them, Figure 3 As shown, the present application provides a column adapter 8 at the inlet end of the liquid adding column 7 (represented by the 5ml liquid adding column 7), and the column adapter 8 is cylindrical and matches the shape of the inlet end of the liquid adding column 7 to form a sealed connection; a sliding plunger 9 is sealedly connected to the column adapter 8, and the sliding plunger 9 can form a sealed connection with the gun head;

[0032] Wherein, a dripping plug 11 is installed at the outlet end of the liquid adding column 7. Figure 5 , Figure 6 As shown, the drip plug 11 has a tube body, one end of which is open and can be sealingly sleeved on the outlet end of the liquid-adding column 7, and the other end of the tube body is integrally formed with a sealing sheet 13, and a linear gap 14 is formed on the sealing sheet 13. The linear gap 14 can normally maintain the sealing of the outlet end of the liquid-adding column 7 under normal pressure. In addition, a radial flange 15 (of course including a circle of radial flanges) is integrally formed on the relatively outer side of the tube body. The drip plug 11 is made of elastic material as a whole. When the two radial flanges 15 are subjected to axial force, the sealing sheet 13 will be deformed, and the linear gap 14 will deform accordingly and no longer maintain the sealing of the outlet end of the liquid-adding column 7.

[0033] Please refer to Figure 1 , Figure 2 The movable column frame 1 is formed with a plurality of upper stepped holes, each of which can be used for the upper end of a liquid adding column 7 to be inserted and fixed, and the pull rod support plate 4 is formed with a plurality of lower stepped holes, each of which can be used for a dripping plug 11 sleeved on the outlet end of the liquid adding column 7 to be placed, and the radial flange 15 of the dripping plug 11 is in contact with the step surface 16 of the lower stepped hole;

[0034] A slide column pressure plate 10 is also provided on the mobile column frame 1, and the slide column pressure plate 10 is connected to the mobile column frame 1 through a pressure plate screw 12. The slide column pressure plate 10 is provided with a bell mouth 17 corresponding to the open end of each liquid adding column 7, and the open end of the liquid adding column 7, the column adapter 8, the slide plunger 9 and the lower surface of the bell mouth 17 are sealed in sequence;

[0035] Please refer to Figure 1 , Figure 4 The movable column frame 1 is provided with a plurality of upper countersunk holes from top to bottom, and the pull rod support plate 4 is provided with a plurality of lower countersunk holes from bottom to top. The upper screws 5 inserted into the upper countersunk holes and the lower screws 6 inserted into the lower countersunk holes are respectively connected with the two ends of the sliding column pull rod 3 by threads, so that the movable column frame 1 and the pull rod support plate 4 are connected together; by adjusting the falling depth of the upper screws 5 and the lower screws 6, the distance between the movable column frame 1 and the pull rod support plate 4 can be made consistent with the length of the liquid adding column 7, and the radial flange 15 of the drip plug 11 does not have a relative force with the step surface 16 of the lower stepped hole under normal conditions, and the linear gap 14 of the sealing sheet 13 of the drip plug 11 is in a sealed state, and the liquid in the liquid adding column 7 will not flow out.

[0036] Once the module brings the gun head to apply external force to the sliding plunger 9 at the sliding column pressure plate 10, the sliding plunger 9 is first sealed with the gun head, and then the external force given by the module causes the column adapter 8 to squeeze the liquid adding column 7, and the liquid adding column 7 moves downward as a whole. Then, the radial flange 15 of the drip plug 11 is blocked by the step surface 16 of the lower stepped hole, which will cause the sealing sheet 13 to deform, and the linear gap 14 will deform accordingly and no longer remain sealed, and the liquid in the liquid adding column 7 will flow out from the outlet end.

[0037] It can be seen that by adopting the above structure, the present application can quickly switch the sealing and flow states of the outlet ends of all liquid-adding columns 7, and there are no pipelines or valves at the outlet ends of the liquid-adding columns 7, which can avoid cross-contamination caused during movement, as well as problems such as too many pipelines hindering operation and aesthetics.

[0038] like Figure 1As shown, a sliding column block 2 is installed at each end of the movable column frame 1, so as to keep the entire device intact while being able to move as a whole, so that the entire device cannot move independently during operation, and can only slide to the collection bottle, elution tank, waste liquid tank, etc. driven by external power.

[0039] Among them, in order to facilitate smooth sliding under the action of external force and reduce friction, the movable column rack 1 is designed to be parallel to the slide rod at both ends as much as possible during design, so that the arc size is the same as the diameter of the slide rod to ensure a smooth sliding process. In addition, in order not to increase additional friction and facilitate installation, the contact surface between the movable column rack 1 and the slide rod is minimized while ensuring a smooth sliding process. The lower end of the movable column rack 1 except the contact surface is specially processed into a certain contraction angle as a guide during the installation process, and it slides into the equipment along the angle to facilitate better installation and reduce the corresponding friction. The material is acid-resistant PP material, which facilitates the rapid movement of the entire column rack in the equipment. This device is designed with a floating installation method and can be installed without any tools. The purpose is to meet the requirements of simple operation and convenient replacement of the movable column rack 1, which can effectively avoid maintenance and greatly improve the sample processing efficiency.

[0040] Moreover, the material of the drip plug 11 is preferably silicone rubber, which has good elasticity and can realize multiple opening and closing actions. The two radial flanges 15 are preferably rectangular when viewed from above to ensure left-right anti-rotation.

[0041] The above description is only illustrative rather than restrictive of the present invention. Those skilled in the art will understand that many modifications, changes or equivalents may be made without departing from the spirit and scope defined by the claims, but all will fall within the scope of protection of the present invention.

Claims

1. An extraction column placement device, characterized in that: It has a mobile column frame, a sliding column pressing plate located above the mobile column frame, a pull rod supporting plate fixed below the mobile column frame, and a liquid adding column with two ends respectively fixed to the mobile column frame and the pull rod supporting plate; The inlet end of the liquid adding column is provided with a column adapter, which is cylindrical and matches the shape of the inlet end of the liquid adding column to form a sealed connection; a sliding plunger is sealedly connected to the column adapter, and the sliding plunger can form a sealed connection with the gun head; The outlet end of the liquid adding column is provided with a dripping plug, the dripping plug having a linear gap which is kept sealed under normal conditions, and the dripping plug is also provided with a radial flange which can open the linear gap, and the lower side of the radial flange is in corresponding contact with the pull rod support plate; wherein the dripping plug has a tube body, one end of which is open so as to be able to be sealed and sleeved on the outlet end of the liquid adding column, the other end of the tube body is integrally formed with a sealing sheet, and the linear gap is formed on the sealing sheet, and two radial flanges are integrally formed on the opposite outer sides of the tube body, and the two radial flanges are rectangular in top view; The inlet end of the liquid adding column is sealed and connected to the lower side of the slide column pressure plate through a sealing element, and the slide column pressure plate can controllably apply force downward to the inlet end of the liquid adding column, so that a relative movement trend is generated between the radial flange of the drip plug at the outlet end of the liquid adding column and the pull rod support plate; The movable column frame is formed with a plurality of upper stepped holes, each of which can be used for the upper end of a liquid adding column to be inserted and fixed, and the pull rod support plate is formed with a plurality of lower stepped holes, each of which can be used for a dripping plug sleeved on the outlet end of the liquid adding column to be inserted, and the two radial flanges of the dripping plug are in contact with the step surface of the lower stepped hole; The slide column pressure plate is provided with a bell mouth corresponding to the open end of each liquid adding column, and the open end of the liquid adding column, the column adapter, the slide plunger and the lower surface of the bell mouth are sealed in sequence; The movable column frame is provided with a plurality of upper countersunk holes from top to bottom, and the pull rod support plate is provided with a plurality of lower countersunk holes from bottom to top. The upper screws inserted into the upper countersunk holes and the lower screws inserted into the lower countersunk holes are respectively connected to the two ends of a sliding column pull rod through threads, thereby connecting the movable column frame and the pull rod support plate together.

2. The extraction column placement device according to claim 1, characterized in that: The dripping plug is made of silicone rubber.

3. The extraction column placement device according to claim 1, characterized in that: The slide column pressure plate is connected to the movable column frame through a pressure plate screw.

4. The extraction column placement device according to claim 1, characterized in that: A sliding column stopper is respectively installed at the two ends of the movable column frame.

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