A nitrogen filling structure for a liquid vial filling machine

Abstract

The present invention discloses a nitrogen filling structure for a liquid vial filling machine, comprising a pre-filling nitrogen filling module, a filling station, a post-filling nitrogen filling module, an S-shaped post-filling nitrogen curtain protection module, a plugging station, a rubber plug nitrogen replacement module, and a plugging nitrogen replacement module, which are sequentially arranged on a machine frame from front to back. The pre-filling and post-filling nitrogen filling modules are each arranged on a filling needle rack and an independent lifting mechanism; the pre-filling and post-filling nitrogen filling modules have the same structure and include a nitrogen filling needle rack, a nitrogen pipe, a nitrogen distribution pipe, several nitrogen filling needles, and several nitrogen hoses; the post-filling nitrogen curtain protection module is arranged above a post-filling vial conveyor belt and includes a nitrogen curtain charging trough, a nitrogen curtain baffle, a nitrogen curtain flow equalizing plate, and two nitrogen curtain gas storage tank side walls; the rubber plug nitrogen replacement module includes a rubber plug nitrogen curtain charging trough and a rubber plug nitrogen curtain gas storage trough, which are arranged inside an upper plug channel; and the plugging nitrogen replacement module includes a gas storage chamber, an upper plugging nitrogen curtain flow equalizing plate, and a lower plugging nitrogen curtain flow equalizing plate. The invention can effectively reduce the residual oxygen content in the vial.

Description

Technical Field

[0001] The invention relates to a nitrogen filling structure of a liquid syringe bottle filling machine. Background Art

[0002] For many types of injections that use nitrogen filling technology, measuring the residual oxygen content has become crucial, and it has also become an important quality indicator for consistency evaluation of injections. Therefore, many pharmaceutical companies have put forward higher requirements for the residual oxygen content index of injections, especially for easily oxidized preparations such as fat emulsions and amino acids. The residual oxygen content is the main factor affecting the shelf life of their products. If the residual oxygen content in the injection does not meet the internal control standard, the product may be affected by the residual oxygen and the stability of the product may be affected. In severe cases, it may even deteriorate. Studies have found that by controlling the proportion of gas components in the package, the oxidation reaction with oxygen as the substrate can be significantly inhibited, thereby effectively extending the shelf life of the product or improving the storage quality. The effect of nitrogen protection depends on the concentration of residual oxygen in the injection package. For injections packaged in vials, there are still the following problems in achieving a lower residual oxygen content index for vials by nitrogen filling:

[0003] 1. The diversity of filling volumes makes the layout of the nitrogen filling device difficult;

[0004] 2. How to reduce the impact of the isolator's Class A laminar airflow on the residual oxygen content of vials after nitrogen replacement before and after filling;

[0005] 3. How to evenly distribute nitrogen to the vials at each workstation during pre-filling and post-filling? Ensuring uniform nitrogen filling volume for a single-head needle is very difficult.

[0006] 4. How to ensure the uniformity of airflow and the stability of nitrogen pressure at all locations within the nitrogen curtain before plugging;

[0007] 5. The complexity of the mechanical structure, space limitations, and variety of specifications of the top-type plugging station make it difficult to implement a nitrogen protection structure at the plugging station;

[0008] 6. The nitrogen replacement in the bottom hole of the upper plug and the nitrogen protection of the plug before plugging are challenges to the residual oxygen content index that are easily overlooked. Summary of the Invention

[0009] The purpose of the present invention is to overcome the defects of the prior art and provide a nitrogen filling structure for a liquid vial filling machine, which can effectively reduce the residual oxygen content in the vial, ensure the quality of the medicine and extend the shelf life of the medicine.

[0010] The object of the present invention is achieved as follows: a nitrogen filling structure of a liquid penicillin bottle filling machine includes a pre-filling nitrogen filling module, a filling station, a post-filling nitrogen filling module, an S-shaped post-filling nitrogen curtain protection module and a plugging station, which are arranged on the frame from front to back; a plug nitrogen replacement module is arranged on the upper plug channel next to the plugging station; the plugging station is provided with a plugging nitrogen replacement module; wherein,

[0011] The nitrogen filling module before filling is integrated on the filling needle holder and rises and falls synchronously with the filling curve;

[0012] The post-filling nitrogen filling module is installed on an independent lifting mechanism; the post-filling nitrogen filling module has the same structure as the pre-filling nitrogen filling module and includes a nitrogen filling needle rack, a nitrogen pipe, a nitrogen distribution pipe, a plurality of nitrogen filling needles and a plurality of nitrogen hoses; wherein, the lifting mechanism is arranged on the frame; the nitrogen filling needle rack includes a needle rack connecting rod fixed on the lifting mechanism and a rectangular needle rack plate connected to the front end of the needle rack connecting rod, and a plurality of grooves are provided at intervals on the front end surface of the needle rack plate, and the spacing of the plurality of grooves is adapted to the spacing of the vials on the vial conveyor belt and is just aligned with the vials on the vial conveyor belt; the nitrogen pipe passes through Arranged on the needle holder connecting rod, one end of the nitrogen pipe is connected to the nitrogen storage tank; the nitrogen distribution pipe is fixed to the rear of the top surface of the needle holder plate, and a plurality of nitrogen distribution holes are provided on the nitrogen distribution pipe at intervals along the length direction. Both ends of the nitrogen distribution pipe are connected to the other end of the nitrogen pipe through a hose tee; a plurality of nitrogen charging needles are respectively embedded in a plurality of grooves on the needle holder plate through a bracket; one end of a plurality of nitrogen hoses is connected to the upper ends of the plurality of nitrogen charging needles in a one-to-one manner, and the other ends of the plurality of nitrogen hoses are connected to the plurality of nitrogen distribution holes on the nitrogen distribution pipe in a one-to-one manner;

[0013] The post-filling nitrogen curtain protection module is arranged above the post-filling cillin bottle conveyor belt and includes a nitrogen curtain aeration tank, a nitrogen curtain baffle, a nitrogen curtain flow equalizing plate and two nitrogen curtain gas storage tank side walls; wherein, the nitrogen curtain aeration tank is in an inverted U shape and includes a nitrogen curtain top plate and two aeration tank side walls connected to the two side ends of the nitrogen curtain top plate; a plurality of nitrogen curtain air inlets are arranged on the nitrogen curtain top plate at intervals along the conveying path of the cillin bottle; the nitrogen curtain baffle is horizontally arranged at the middle of the height of the nitrogen curtain aeration tank, and the nitrogen curtain baffle is arranged at the middle of the height of the nitrogen curtain aeration tank. Ventilation gaps are left between both sides of the plate and the side walls of the two aeration tanks; the nitrogen curtain equalizing plate is connected across the bottom surfaces of the two aeration tank side walls, and multiple air discharge holes are provided on the nitrogen curtain equalizing plate at intervals along the conveying path of the cillin bottle; the two nitrogen curtain gas storage tank side walls are symmetrically connected to the two side ends of the nitrogen curtain equalizing plate, and together with the nitrogen curtain equalizing plate, form an inverted U-shaped nitrogen curtain gas storage tank. The two gas storage tank side walls are both inwardly inclined arc curved panels, so that the bottle mouth of the cillin bottle is located in the nitrogen curtain gas storage tank;

[0014] The plug nitrogen replacement module includes a plug nitrogen curtain inflation tank and a plug nitrogen curtain air storage tank provided on the inner side of the upper plug channel; wherein, the center of the upper plug channel is provided with an air permeable groove aligned with the bottom groove of the plug along the upper plug path; the plug nitrogen curtain inflation tank has the same structure as the nitrogen curtain inflation tank; the plug nitrogen curtain air storage tank includes an air storage tank top plate, a U-shaped groove plate and a vertical baffle; the air storage tank top plate is fixed to the bottom surface of the plug nitrogen curtain inflation tank, and the center of the air storage tank top plate is provided with an air inlet groove along the upper plug path; the width of the U-shaped groove plate is equal to the sum of the width of the plug nitrogen curtain inflation tank and the width of the upper plug channel, the top end of the inner side wall of the U-shaped groove plate is connected to the inner end of the air storage tank top plate, and the top end of the outer side wall of the U-shaped groove plate is connected to the outer end of the upper plug channel; the vertical baffle is connected to the outer end of the air storage tank top plate, and a ventilation gap is left between the bottom end of the vertical baffle and the bottom plate of the U-shaped groove plate;

[0015] The plugging nitrogen replacement module includes a gas storage chamber with a rectangular cross section, an upper plugging nitrogen curtain flow equalizing plate and a lower plugging nitrogen curtain flow equalizing plate; the gas storage chamber is divided into an upper shielding nitrogen curtain gas storage chamber and a lower needle-shaped nitrogen curtain gas storage chamber by a transverse partition at the middle of the height of the gas storage chamber; a shielding nitrogen curtain air inlet is provided on the top plate of the shielding nitrogen curtain gas storage chamber, and a ring-shaped shielding nitrogen curtain air jet is provided in the middle of the outer side wall of the shielding nitrogen curtain gas storage chamber; the inner side wall of the needle-shaped nitrogen curtain gas storage chamber A needle-shaped nitrogen curtain air inlet is opened on the upper part, and a row of needle-shaped nitrogen curtain air jets is opened in the middle of the outer side wall of the needle-shaped nitrogen curtain gas storage chamber; the upper pressure plug nitrogen curtain flow equalizing plate and the lower pressure plug nitrogen curtain flow equalizing plate are vertically connected to the middle of the top surface and the middle of the bottom surface of the diaphragm in a one-to-one correspondence; a ventilation gap is left between the top end of the upper pressure plug nitrogen curtain flow equalizing plate and the top plate of the shielding nitrogen curtain gas storage chamber; a ventilation gap is also left between the bottom end of the lower pressure plug nitrogen curtain flow equalizing plate and the bottom plate of the needle-shaped nitrogen curtain gas storage chamber.

[0016] In the above-mentioned nitrogen filling structure of the liquid syringe bottle filling machine, the number of the grooves on the needle holder plate is eight.

[0017] The nitrogen filling structure of the liquid syringe bottle filling machine of the present invention has the following characteristics:.

[0018] 1) Nitrogen filling before and after filling is used to replace the air in the vial with nitrogen. Post-filling nitrogen curtain protection before plugging, needle-shaped nitrogen curtain protection and shielding nitrogen curtain protection at the plugging station, as well as nitrogen replacement modules for the rubber stopper located on the upper plugging channel are also used. These modules fully cover the main process of vial filling and plugging, as well as the entire bottle transportation channel, effectively ensuring drug quality and extending the shelf life of the drugs.

[0019] 2) Unique nitrogen distribution device for nitrogen filling before and after filling, and unique "maze-type" nitrogen diversion structure designed inside the nitrogen curtain, thus ensuring uniform and stable nitrogen distribution in each section;

[0020] 3) The Coanda effect principle is applied to nitrogen curtain protection, effectively weakening the impact of the isolator's Class A laminar flow on the residual oxygen content of the filled vials after nitrogen replacement, and directing the external laminar flow to other areas, thereby shielding the interference of the external laminar flow;

[0021] 4) According to the particularity of nitrogen demand in each work section, especially the nitrogen replacement of empty bottles before filling, the replacement of liquid headspace after filling, and the trace replacement of residual oxygen in the groove at the bottom of the stopper, the demand for nitrogen flow and medium pressure are different. Each work station can be designed with an independent nitrogen pressure and flow regulating device to accommodate the different nitrogen demand requirements of each work station. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a top view of the liquid vial filling machine of the present invention;

[0023] Figure 2 It is a structural schematic diagram of a post-filling nitrogen filling module in the nitrogen filling structure of the liquid vial filling machine of the present invention;

[0024] Figure 3 It is a cross-sectional view of a post-filling nitrogen curtain protection module in the nitrogen filling structure of the liquid vial filling machine of the present invention;

[0025] Figure 4 It is a cross-sectional view of a stopper nitrogen replacement module in the nitrogen filling structure of the liquid vial filling machine of the present invention;

[0026] Figure 5 It is a cross-sectional view of the plug nitrogen replacement module in the nitrogen filling structure of the liquid penicillin bottle filling machine of the present invention. DETAILED DESCRIPTION

[0027] The present invention will be further described below with reference to the accompanying drawings.

[0028] See also Figures 1 to 5 The nitrogen filling structure of the liquid vial filling machine of the present invention includes a pre-filling nitrogen filling module 1, a filling station 10, a post-filling nitrogen filling module 2, an S-shaped post-filling nitrogen curtain protection module 3, and a plugging station 20, which are sequentially arranged on the frame from front to back; a rubber plug nitrogen replacement module 5 is provided on the upper plug channel 2A next to the plugging station 20; and a plugging nitrogen replacement module 4 is provided at the plugging station 20.

[0029] The nitrogen filling module 1 before filling is integrated into the filling needle holder and rises and falls synchronously with the filling curve to replace the empty vials 30 with nitrogen before filling;

[0030] The post-filling nitrogen filling module 3 is installed on an independent lifting mechanism 21 to accommodate different bottle types and different filling liquid level height requirements; the post-filling nitrogen filling module 2 has the same structure as the pre-filling nitrogen filling module 1 and includes a nitrogen filling needle rack, a nitrogen pipe 23, a nitrogen distribution pipe 24, eight nitrogen filling needles 25, eight nitrogen hoses 26 and a hose tee 27; wherein, the nitrogen filling needle rack includes a needle rack connecting rod 221 fixed to the lifting mechanism 21 and a rectangular needle rack plate 222 connected to the front end of the needle rack connecting rod 221, and a plurality of grooves are provided at intervals on the front end surface of the needle rack plate 222, and the spacing of the plurality of grooves is adapted to the spacing of the vials on the vial conveyor belt and is exactly aligned with the vials on the vial conveyor belt. 30; The nitrogen pipe 23 is passed through the needle holder connecting rod 221, and one end of the nitrogen pipe 23 is connected to the nitrogen storage tank; the nitrogen distribution pipe 24 is fixed to the rear portion of the top surface of the needle holder plate 222, and eight nitrogen distribution holes are provided on the nitrogen distribution pipe 24 at intervals along the length direction. The two ends of the nitrogen distribution pipe 24 are connected to the other end of the nitrogen pipe 23 through a hose tee 27; the eight nitrogen filling needles 25 are each embedded in the eight grooves on the needle holder plate 222 through a bracket; one end of the eight nitrogen hoses 26 is connected to the upper ends of the several nitrogen filling needles 25 in a one-to-one manner, and the other ends of the eight nitrogen hoses 26 are connected to the eight nitrogen distribution holes on the nitrogen distribution pipe 24 in a one-to-one manner.

[0031] The post-filling nitrogen filling module 2 and the pre-filling nitrogen filling module 1 operate as follows: Medical high-purity nitrogen 40 enters the nitrogen distribution pipe 24 via the nitrogen pipe 23 and the hose tee 27. It is then delivered to eight nitrogen filling needles 25 via eight nitrogen hoses 26. The eight nitrogen filling needles 25 inject nitrogen into eight corresponding vials 30, replacing the air in the empty vials and the air at the top of the liquid level in the filled vials, ensuring a uniform and stable residual oxygen level in each vial 30. The diameter of the hose tee 27 should be larger than that of the nitrogen hose 26 to ensure an adequate nitrogen supply.

[0032] The post-filling nitrogen curtain protection module 3 is arranged above the post-filling penicillin bottle conveyor belt and includes a nitrogen curtain gas filling tank 32, a nitrogen curtain baffle 33, a nitrogen curtain flow equalizing plate 34 and two nitrogen curtain gas storage tank side walls 35; wherein the nitrogen curtain gas filling tank 32 is in an inverted U shape and includes a nitrogen curtain top plate 321 and two gas filling tank side walls 322 connected to the two side ends of the nitrogen curtain top plate 321; a plurality of nitrogen curtain air inlets 31 are spaced apart on the nitrogen curtain top plate 321 along the conveying path of the penicillin bottle 30; the nitrogen curtain baffle 33 is horizontally arranged at the middle of the height of the nitrogen curtain gas filling tank 32, and the two sides of the nitrogen curtain baffle 33 are connected to the nitrogen curtain baffle 33. A ventilation gap is left between the two aeration tank side walls 322; a nitrogen curtain equalizing plate 34 is connected between the bottom surfaces of the two aeration tank side walls 322, and a plurality of exhaust holes are provided on the nitrogen curtain equalizing plate 34 at intervals along the conveying path of the cillin bottle, with each exhaust hole having three holes; the nitrogen curtain gas storage tank side walls 35 are symmetrically connected to the two side ends of the nitrogen curtain equalizing plate 34, and together with the nitrogen curtain equalizing plate 34, form an inverted U-shaped nitrogen curtain gas storage tank. The two gas storage tank side walls 35 are both inwardly inclined arc curved panels and have a "Coanda effect", so that the bottle mouth of the cillin bottle 30 is located within the nitrogen curtain gas storage tank;

[0033] The working principle of the post-filling nitrogen curtain protection module 3 is as follows: after the vial 30 is filled with the drug solution 3A, it is transported to the bottom of the post-filling nitrogen curtain protection module 3; the medical high-purity nitrogen 40 enters the nitrogen curtain charging tank 32 from the nitrogen curtain air inlet 31, then encounters the nitrogen curtain baffle 33 and is guided to the ventilation gap between the two sides of the nitrogen curtain baffle 33 and the charging tank sidewall 322 to the lower part of the nitrogen curtain charging tank 32, and is filled into the vial 30 through the air outlet on the nitrogen curtain flow equalizing plate 34. The air 3B at the top of the liquid surface in the vial 30 is completely replaced with high-purity nitrogen 40. At the same time, the external laminar flow encounters the gas storage tank sidewall 35 and is guided away from the vial 30 by the concave curved surface of the gas storage tank sidewall 35, thereby isolating the external laminar flow from affecting the nitrogen filling effect of the vial 30.

[0034] The plug nitrogen replacement module 5 includes a plug nitrogen curtain charging tank 52 and a plug nitrogen curtain gas storage tank 54 provided on the inner side of the upper plug channel 2A; wherein, the center of the upper plug channel 2A is provided with a breathable groove aligned with the bottom groove of the plug 50 along the upper plug path; the plug nitrogen curtain charging tank 52 has the same structure as the nitrogen curtain charging tank 32, and a nitrogen inlet 51 is provided on the top plate of the plug nitrogen curtain charging tank 52; a plug nitrogen curtain baffle 53 is provided in the plug nitrogen curtain charging tank 52; the plug nitrogen curtain gas storage tank 54 includes a gas storage tank top plate 541, a U-shaped groove plate 542 and a vertical baffle 543; the gas storage tank top plate 541 is fixed Fixed on the bottom surface of the nitrogen curtain charging groove 52 of the rubber plug, the center of the gas storage tank top plate 541 is provided with an air inlet groove along the upper plug path; the width of the U-shaped groove plate 542 is equal to the sum of the width of the nitrogen curtain charging groove 52 of the rubber plug and the width of the upper plug channel 2A, so that the top end of the inner wall of the U-shaped groove plate 542 is connected to the inner end of the gas storage tank top plate 541, and the top end of the outer wall of the U-shaped groove plate 542 is connected to the outer end of the upper plug channel 2A; the vertical baffle plate 543 is connected to the outer end of the gas storage tank top plate 541, and a ventilation gap is left between the bottom end of the vertical baffle plate 543 and the bottom plate of the U-shaped groove plate 542.

[0035] Considering that there is oxygen in the bottom groove of the stopper 50 in the upper stopper channel 2A before entering the stoppering station 20, which will affect the residual oxygen content index of the vial 30, it is necessary to replace the air in the bottom groove of the stopper 50 with nitrogen in the upper stopper channel 2A and shield it.

[0036] The working principle of the plug nitrogen replacement module 5 is as follows: high-purity nitrogen 40 enters the plug nitrogen curtain charging tank 52 through the plug nitrogen inlet 51, diffuses to the surrounding area on the surface of the plug nitrogen curtain charging tank 52 after passing through the plug nitrogen curtain baffle 53, and then enters the plug nitrogen curtain gas storage tank 54 through the air inlet groove provided on the gas storage tank top plate 541, and enters the bottom of the upper plug channel 2A through the vertical baffle 543. Finally, it slowly overflows through the air permeability groove on the upper plug channel 2A, replacing the residual oxygen in the bottom groove of the plug 50. The specially designed plug nitrogen replacement module 5 here prevents the oxygen hidden in the bottom groove of the plug 50 from being introduced into the vial 30, effectively reducing the residual oxygen content in the vial.

[0037] The plugging nitrogen replacement module 4 includes a gas storage chamber with a rectangular cross section, an upper plugging nitrogen curtain flow equalizing plate and a lower plugging nitrogen curtain flow equalizing plate; wherein, the gas storage chamber is divided into an upper shielding nitrogen curtain gas storage chamber 42 and a lower needle-shaped nitrogen curtain gas storage chamber 44 by a transverse partition 45 at the middle of the height of the gas storage chamber; a shielding nitrogen curtain air inlet 41 is provided on the top plate of the shielding nitrogen curtain gas storage chamber 42, and a ring-shaped shielding nitrogen curtain air injection port 420 is provided in the middle of the outer wall of the shielding nitrogen curtain gas storage chamber 42; the inner wall of the needle-shaped nitrogen curtain gas storage chamber 44 A needle-shaped nitrogen curtain air inlet 43 is provided at the upper part, and a row of needle-shaped nitrogen curtain air injection ports 440 are provided in the middle of the outer side wall of the needle-shaped nitrogen curtain gas storage chamber; the upper pressure plug nitrogen curtain flow equalizing plate 46 and the lower pressure plug nitrogen curtain flow equalizing plate 47 are vertically connected to the middle of the top surface and the middle of the bottom surface of the diaphragm 45 in a one-to-one correspondence, and a ventilation gap is left between the top end of the upper pressure plug nitrogen curtain flow equalizing plate 46 and the top plate of the shielding nitrogen curtain gas storage chamber 42, and a ventilation gap is also left between the bottom end of the lower pressure plug nitrogen curtain flow equalizing plate 47 and the bottom plate of the needle-shaped nitrogen curtain gas storage chamber 44.

[0038] After being filled with the medicinal liquid 3A, the vial 30 is transferred to the plugging station 20 by a star wheel under the continuous protection of the post-filling nitrogen charging module 2 and the post-filling nitrogen curtain protection module 3. To replace the outside air unintentionally introduced during this process, pressure-regulated high-purity nitrogen 40 is introduced into the shielding nitrogen curtain air inlet 41 and the needle-shaped nitrogen curtain air inlet 43. After passing through the upper plugging nitrogen curtain equalizing plate 46 and the lower plugging nitrogen curtain equalizing plate 47, the high-purity nitrogen 40 is diffused around its surface, so that the gas source is evenly distributed throughout the shielding nitrogen curtain gas storage chamber 42 and the needle-shaped nitrogen curtain gas storage chamber 44. The gas is then injected into the vial 30 above the liquid level of the medicinal liquid 3A through the needle-shaped nitrogen curtain air jet 440. The medicinal liquid 3A in the vial 30 can be continuously protected by the nitrogen 40 throughout the entire plugging process. At the same time, an annular shielding nitrogen curtain air jet 420 is designed above the bottle mouth of the vial 30 to shield the negative interference of the external laminar air on the plugging process during the entire plugging process, thereby ensuring the quality of the medicine.

[0039] The above embodiments are only used to illustrate the present invention, rather than to limit the present invention. Those skilled in the art may make various changes or modifications without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions should also fall within the scope of the present invention and should be defined by the claims.

Claims

1. A nitrogen filling structure for a liquid vial filling machine, comprising a pre-filling nitrogen filling module, a filling station, a post-filling nitrogen filling module, an S-shaped post-filling nitrogen curtain protection module, and a plugging station, which are sequentially arranged on a frame from front to back; a plugging nitrogen replacement module is arranged on the upper plugging channel next to the plugging station; the plugging nitrogen replacement module is arranged at the plugging station; and the plugging nitrogen replacement module is provided; characterized in that: The nitrogen filling module before filling is integrated on the filling needle holder and rises and falls synchronously with the filling curve; The post-filling nitrogen filling module is installed on an independent lifting mechanism; the post-filling nitrogen filling module has the same structure as the pre-filling nitrogen filling module and includes a nitrogen filling needle rack, a nitrogen pipe, a nitrogen distribution pipe, a plurality of nitrogen filling needles and a plurality of nitrogen hoses; wherein, the lifting mechanism is arranged on the frame; the nitrogen filling needle rack includes a needle rack connecting rod fixed on the lifting mechanism and a rectangular needle rack plate connected to the front end of the needle rack connecting rod, and a plurality of grooves are provided at intervals on the front end surface of the needle rack plate, and the spacing of the plurality of grooves is adapted to the spacing of the vials on the vial conveyor belt and is just aligned with the vials on the vial conveyor belt; the nitrogen pipe passes through Arranged on the needle holder connecting rod, one end of the nitrogen pipe is connected to the nitrogen storage tank; the nitrogen distribution pipe is fixed to the rear of the top surface of the needle holder plate, and a plurality of nitrogen distribution holes are provided on the nitrogen distribution pipe at intervals along the length direction. Both ends of the nitrogen distribution pipe are connected to the other end of the nitrogen pipe through a hose tee; a plurality of nitrogen charging needles are respectively embedded in a plurality of grooves on the needle holder plate through a bracket; one end of a plurality of nitrogen hoses is connected to the upper ends of the plurality of nitrogen charging needles in a one-to-one manner, and the other ends of the plurality of nitrogen hoses are connected to the plurality of nitrogen distribution holes on the nitrogen distribution pipe in a one-to-one manner; The post-filling nitrogen curtain protection module is arranged above the post-filling cillin bottle conveyor belt and includes a nitrogen curtain aeration tank, a nitrogen curtain baffle, a nitrogen curtain flow equalizing plate and two nitrogen curtain gas storage tank side walls; wherein, the nitrogen curtain aeration tank is in an inverted U shape and includes a nitrogen curtain top plate and two aeration tank side walls connected to the two side ends of the nitrogen curtain top plate; a plurality of nitrogen curtain air inlets are arranged on the nitrogen curtain top plate at intervals along the conveying path of the cillin bottle; the nitrogen curtain baffle is horizontally arranged at the middle of the height of the nitrogen curtain aeration tank, and the nitrogen curtain baffle is arranged at the middle of the height of the nitrogen curtain aeration tank. Ventilation gaps are left between both sides of the plate and the side walls of the two aeration tanks; the nitrogen curtain equalizing plate is connected across the bottom surfaces of the two aeration tank side walls, and multiple air discharge holes are provided on the nitrogen curtain equalizing plate at intervals along the conveying path of the cillin bottle; the two nitrogen curtain gas storage tank side walls are symmetrically connected to the two side ends of the nitrogen curtain equalizing plate, and together with the nitrogen curtain equalizing plate, form an inverted U-shaped nitrogen curtain gas storage tank. The two gas storage tank side walls are both inwardly inclined arc curved panels, so that the bottle mouth of the cillin bottle is located in the nitrogen curtain gas storage tank; The plug nitrogen replacement module includes a plug nitrogen curtain inflation tank and a plug nitrogen curtain air storage tank provided on the inner side of the upper plug channel; wherein, the center of the upper plug channel is provided with an air permeable groove aligned with the bottom groove of the plug along the upper plug path; the plug nitrogen curtain inflation tank has the same structure as the nitrogen curtain inflation tank; the plug nitrogen curtain air storage tank includes an air storage tank top plate, a U-shaped groove plate and a vertical baffle; the air storage tank top plate is fixed to the bottom surface of the plug nitrogen curtain inflation tank, and the center of the air storage tank top plate is provided with an air inlet groove along the upper plug path; the width of the U-shaped groove plate is equal to the sum of the width of the plug nitrogen curtain inflation tank and the width of the upper plug channel, the top end of the inner side wall of the U-shaped groove plate is connected to the inner end of the air storage tank top plate, and the top end of the outer side wall of the U-shaped groove plate is connected to the outer end of the upper plug channel; the vertical baffle is connected to the outer end of the air storage tank top plate, and a ventilation gap is left between the bottom end of the vertical baffle and the bottom plate of the U-shaped groove plate; The plugging nitrogen replacement module includes a gas storage chamber with a rectangular cross section, an upper plugging nitrogen curtain flow equalizing plate and a lower plugging nitrogen curtain flow equalizing plate; the gas storage chamber is divided into an upper shielding nitrogen curtain gas storage chamber and a lower needle-shaped nitrogen curtain gas storage chamber by a transverse partition at the middle of the height of the gas storage chamber; a shielding nitrogen curtain air inlet is provided on the top plate of the shielding nitrogen curtain gas storage chamber, and a ring-shaped shielding nitrogen curtain air jet is provided in the middle of the outer side wall of the shielding nitrogen curtain gas storage chamber; the inner side wall of the needle-shaped nitrogen curtain gas storage chamber A needle-shaped nitrogen curtain air inlet is opened on the upper part, and a row of needle-shaped nitrogen curtain air jets is opened in the middle of the outer side wall of the needle-shaped nitrogen curtain gas storage chamber; the upper pressure plug nitrogen curtain flow equalizing plate and the lower pressure plug nitrogen curtain flow equalizing plate are vertically connected to the middle of the top surface and the middle of the bottom surface of the diaphragm in a one-to-one correspondence; a ventilation gap is left between the top end of the upper pressure plug nitrogen curtain flow equalizing plate and the top plate of the shielding nitrogen curtain gas storage chamber; a ventilation gap is also left between the bottom end of the lower pressure plug nitrogen curtain flow equalizing plate and the bottom plate of the needle-shaped nitrogen curtain gas storage chamber.

2. The nitrogen filling structure of the liquid vial filling machine according to claim 1, characterized in that: The number of the grooves on the needle holder plate is eight.

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