Multi-point monitoring device for each plate layer of freeze dryer and freeze dryer containing the same

Abstract

The present invention belongs to the technical field of freeze dryer equipment and devices, and relates to a multi-point monitoring device for each plate layer of a freeze dryer and a freeze dryer containing the same. The terminal is connected to a first detection probe for detecting a partition layer and a second detection probe for detecting the temperature inside a freeze-dried bottle; and a microprocessor chip is provided inside the terminal for controlling the first detection probe to start detection and the second detection probe to start detection respectively; and also includes a refrigeration system, a first refrigeration unit is provided inside the freeze dryer, and a second refrigeration unit is provided on a partition in each partition layer. The first refrigeration unit is used for refrigeration work inside the freeze dryer, and the second refrigeration unit is used for the freeze-dried bottles placed on the partitions in each partition layer. The first refrigeration unit and the second refrigeration unit are respectively connected to the refrigeration system with electrical signals.

Description

Technical Field

[0001] The present invention belongs to the technical field of freeze dryer equipment and relates to a freeze dryer monitoring device and a freeze dryer thereof, and more specifically to a multi-point monitoring device for each plate layer of a freeze dryer and a freeze dryer comprising the same. Background Art

[0002] The basic principle of freeze-drying is based on the three states of water. Water exists in solid, liquid, and gas, and these three states can both transition and coexist. When water is at the triple point, water, ice, and water vapor can coexist and maintain equilibrium. Based on the principle that decreasing pressure lowers the boiling point, as long as the pressure is below the triple point, the water in the material can sublime directly from water to water vapor, bypassing the liquid phase. Based on this principle, the wet material is first frozen below its freezing point, converting the water content into solid ice. Then, under a suitable vacuum environment, the ice is directly converted into vapor and removed. The water vapor is then condensed using a water vapor condenser in the vacuum system, thereby drying the material. This vacuum freezing method involves the physical transformation and movement of water, a process that occurs at low temperature and low pressure. Therefore, the basic principle of freeze-drying is the heat and mass transfer mechanism under low temperature and low pressure. The freeze-drying process consists of three steps: pre-freezing to prepare the sample for the subsequent sublimation process, vacuuming, and finally drying. The first drying stage is sublimation drying, followed by the second drying stage: desorption drying. In laboratory or large-scale production operations, the principle of sublimation is used under high vacuum to remove moisture from pre-frozen sample materials by directly sublimating them into water vapor without melting the ice, thereby achieving freeze-drying. Vacuum freeze-drying technology is widely used in biomedicine, biotechnology, pharmaceutical preparations, biological products, food, blood products, and many other fields.

[0003] Existing freeze dryers all use a unified container module. Freeze drying of samples is monitored within the corresponding chambers within the container module. However, due to the different styles of freeze-dried vials placed inside, the temperature inside and outside the vials often differs, resulting in inconsistent or insufficient freeze-drying results. To fully monitor the temperature of both the chambers inside and outside the vials, obtain corresponding indoor and internal temperature data, and adjust and control the temperature within the freeze dryer based on this data, a multi-point monitoring device for each plate layer of the freeze dryer and a freeze dryer containing the same are being introduced. Summary of the Invention

[0004] In order to overcome the above-mentioned shortcomings, the present invention aims to provide a technical solution that can solve the above-mentioned problems.

[0005] According to the first aspect of the present invention, the present invention provides a multi-point monitoring device for each plate layer of a freeze dryer, including a terminal and a partition layer inside the freeze dryer, wherein the partition layer contains a plurality of freeze-dried bottles for placing samples; the characteristic is that: the terminal is connected to a first detection probe for detecting the partition layer and a second detection probe for detecting the temperature inside the freeze-dried bottle; and a microprocessor chip is provided inside the terminal for controlling the first detection probe to start detection and the second detection probe to start detection respectively.

[0006] Furthermore, there is at least one partition layer in the freeze dryer.

[0007] Furthermore, the freeze-drying bottle is provided with a first rubber stopper, the first rubber stopper is provided with an opening, and the second detection probe can extend into the interior of the first rubber stopper along the opening.

[0008] Furthermore, the opening is provided in the middle of the first rubber stopper.

[0009] Furthermore, the terminal is provided with a detection display screen, on which are distributed a plurality of displays for visually observing the data in each partition layer and each freeze-drying bottle.

[0010] According to the second aspect of the present invention, the present invention provides a freeze dryer, which includes a multi-point monitoring device for each plate layer of the freeze dryer; wherein, it also includes a refrigeration system, a first refrigeration unit is provided inside the freeze dryer, and a second refrigeration unit is provided on the partition in each partition layer. The first refrigeration unit is used for refrigeration inside the freeze dryer, and the second refrigeration unit is used for the freeze-dried bottles placed on the partition in each partition layer. The first refrigeration unit and the second refrigeration unit are respectively connected to the refrigeration system electrical signals.

[0011] Furthermore, the first refrigeration unit is configured as a refrigeration pipe or a refrigeration box; and the second refrigeration unit is configured as a semiconductor refrigeration plate.

[0012] Furthermore, the partition layer in the freeze dryer is connected to the freeze dryer in a drawer-type movable manner; and an array of inner groove positions for placing freeze-dried bottles is arranged on the partition layer, and the second refrigeration unit is distributed among the inner groove positions on the partition layer, and performs freeze-drying work for the freeze-dried bottles placed in the inner groove positions.

[0013] Furthermore, a clamping piece for clamping the first detection probe is provided on the inner wall of the freeze dryer.

[0014] Furthermore, a second rubber plug for inserting the first detection probe and the second detection probe is provided on the wall of the freeze dryer, and an opening is also provided on the second rubber plug.

[0015] The beneficial effects of the present invention are:

[0016] (1) The multi-point monitoring device for each plate layer of the freeze dryer and the freeze dryer including the same according to the present invention can realize dual detection of the chamber of the freeze dryer body and the sample inside the freeze-dried bottle, thereby ensuring the accuracy of the sample detection and minimizing the error to the maximum extent;

[0017] (2) The multi-point monitoring device for each plate layer of the freeze dryer and the freeze dryer containing the same according to the present invention can be distributed to perform detection, and the whole process monitoring can be achieved by detecting the stability of the temperature between the plate layers during the freeze drying process and the temperature below the sample liquid surface at the end of the subsequent freeze drying process;

[0018] (3) The present invention ensures the sealing of the indoor cooling environment and the internal cooling environment of the sample through the rubber plug design, thereby achieving the accuracy of the detection probe;

[0019] (4) The multi-point monitoring device for each plate layer of the freeze dryer and the freeze dryer containing the same according to the present invention can achieve a large-scale freeze-drying effect inside the freeze dryer and a targeted freeze-drying effect on the freeze-drying bottles;

[0020] (5) The present invention can adjust the temperature of the bottle by the first control unit and the second control unit respectively, so that the temperature inside and outside the bottle can be kept stable.

[0021] Additional aspects and advantages of the present invention will be set forth in part in the description which follows and, in part, will be obvious from the description which follows, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0023] Figure 2 Schematic diagram of the structure of the freeze-drying bottle placed on the partition.

[0024] Figure 3 Schematic diagram of the clamping structure.

[0025] The accompanying drawings in the figure are marked as follows: terminal-1, partition layer-2, freeze-dried bottle-3, first detection probe-4, second detection probe-5, microprocessor chip-6, first rubber stopper-7, display screen-8, refrigeration system-9, first refrigeration unit-10, second refrigeration unit-11, inner groove position-12, clamping part-13, second rubber stopper-14. DETAILED DESCRIPTION

[0026] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0027] See also Figures 1 to 3 , a multi-point monitoring device for each plate layer of the freeze dryer, including a terminal 1 and a partition layer 2 inside the freeze dryer, wherein the partition layer 2 contains a plurality of freeze-dried bottles 3 for placing samples; it is characterized in that: the terminal 1 is connected to a first detection probe 4 for detecting the partition layer 2 and a second detection probe 5 for detecting the temperature inside the freeze-dried bottle 3; and a microprocessor core is provided inside the terminal 1 for controlling the first detection probe 4 to start the detection and the second detection probe 5 to start the detection respectively; the detection inside the freeze dryer is mainly to realize the detection inside the freeze dryer chamber and the detection inside the freeze-dried bottle 3, and is mainly implemented by controlling the connection between the first detection probe 4 and the second detection probe 5 through the terminal 1, the first detection probe 4 is a multi-probe corresponding to the number of partition layers, and the second detection probe 5 is a multi-probe corresponding to the number of freeze-dried bottles, and the temperature detection data is transmitted to the terminal 1 so that It is displayed that the operator can control the internal temperature according to the data obtained. At the same time, the opening of the first detection probe 4 and the second detection probe 5 can realize synchronous start-up detection or distributed start-up detection through the microprocessor chip 6. Two detection methods can be performed according to actual conditions. When the synchronous start-up detection is performed, the temperature inside the partition layer 2 and the temperature inside the freeze-drying bottle 3 can be observed at any time, which plays a role of real-time synchronous detection. At the same time, it can be completed to check whether the ambient temperature provided by the freeze-drying bottle 3 is consistent with that provided outside the bottle, or whether there is a temperature deviation, so as to facilitate subsequent inspection and timely maintenance of problems; when the first detection probe 4 and the second detection probe 5 are opened and closed in sequence, the stability of the temperature between the plate layers during the freeze-drying process and the temperature inside the freeze-drying bottle 3 at the end of the subsequent freeze-drying can be detected, thereby realizing all-round monitoring of the intermediate process and the final process.

[0028] The partition layer 2 in the freeze dryer has only one layer, and can also be set to multiple layers according to actual conditions, so as to simultaneously place and test large quantities of materials at multiple levels and improve the detection efficiency.

[0029] A first rubber stopper 7 is provided on the freeze-drying bottle 3, and an opening is provided on the first rubber stopper 7. The second detection probe 5 can be inserted into the first rubber stopper 7 along the opening; the first rubber stopper 7 facilitates the insertion and extension of the second detection probe 5. The second rubber stopper 14 itself is made of rubber. Therefore, when the second detection probe 5 is inserted, the sealing of the inside of the freeze-drying bottle 3 can be ensured.

[0030] The opening is provided in the middle of the first rubber stopper 7 , which can prevent the second detection probe 5 from being crushed when the freeze-drying bottle 3 is capped.

[0031] The terminal 1 is provided with a detection display screen 8, on which are distributed multiple data displays for visually observing each partition layer 2 and each freeze-drying bottle 3. The display screen 8 realizes the data display of the first detection probe 4 and the second detection that are turned on, so as to visually observe the internal temperature calibration.

[0032] The freeze dryer includes a multi-point monitoring device for each plate layer of the freeze dryer; wherein, it also includes a refrigeration system 9, a first refrigeration unit 10 is provided inside the freeze dryer, and a second refrigeration unit 11 is provided on the partition in each partition layer 2. The first refrigeration unit 10 is used for refrigeration inside the freeze dryer, and the second refrigeration unit 11 is used for the freeze-dried bottles 3 placed on the partition in each partition layer 2. The first refrigeration unit 10 and the second refrigeration unit 11 are respectively connected to the refrigeration system 9 with electrical signals, and the refrigeration system 9 is connected to the first refrigeration unit 10 and the second refrigeration unit 11 to realize separate control, and the first refrigeration unit 10 can be controlled according to the actual situation. The first refrigeration unit 10 or the second refrigeration unit 11 is turned on or off, or different temperatures are set for each of them. During the freeze-drying and temperature detection operation, if there is a difference between the temperature inside and outside the freeze-dried bottle 3 or the difference is large, the refrigeration system 9 can control the first refrigeration unit 10 and the second refrigeration unit 11 to adjust the refrigeration degree respectively, so that the temperature inside and outside the bottle remains stable and stable, thereby achieving calibration; thereby preventing the freeze-dried bottle 3 from being damaged or even broken due to the temperature difference inside and outside the freeze-dried bottle 3, affecting the subsequent use of the freeze-dried bottle 3, and the freeze-drying effect of the sample in the freeze-dried bottle 3 is better and more stable.

[0033] The first refrigeration unit 10 is configured as a refrigeration tube or refrigeration box; achieving a large-scale internal refrigeration effect; the second refrigeration unit 11 is configured as a semiconductor refrigeration plate and placed in the inner groove position 12, which can achieve a targeted freeze-drying effect on the freeze-drying bottle 3 on the partition layer 2.

[0034] The partition layer 2 in the freeze dryer is connected to the freeze dryer in a drawer-type movable manner; and an array of inner groove positions 12 for placing freeze-dried bottles 3 is arranged on the partition layer 2, and the second refrigeration unit 11 is distributed in the inner groove positions 12 on the partition layer 2, and performs freeze-drying work for the freeze-dried bottles 3 placed in the inner groove positions 12; through the drawer-type movable connection, the partition layer 2 can be easily extended and retracted, and at the same time, the inner groove positions 12 on the partition layer 2 are used to cooperate with the freeze-dried bottles 3 for placement, which can ensure that the freeze-dried bottles 3 are firmly fixed when the partition layer 2 moves, avoiding the freeze-dried bottles 3 on the partition layer 2 from falling off and colliding, and because the second refrigeration unit 11 is placed in the inner groove positions 12, the second refrigeration unit 11 can achieve targeted freeze-drying of the freeze-dried bottles 3 on the inner groove positions 12.

[0035] A clamping member 13 for clamping the first detection probe 4 is provided on the inner wall of the freeze dryer; Figure 3 As known from the embodiment, the clamping member 13 can be configured as a cavity in the middle for accommodating the first detection probe 4 and arc-shaped pieces at both ends, and at the same time have a certain elasticity, thereby ensuring fixed clamping of the first detection probe 4 and avoiding messy placement of the first detection probe 4.

[0036] A second rubber plug 14 for inserting the first detection probe 4 and the second detection probe 5 is provided on the wall of the freeze dryer, and the second rubber plug 14 is also provided with an opening; the first detection probe 4 and the second detection probe 5 are extended into the interior of the freeze dryer through the second rubber plug 14, and the first detection probe 4 is fixedly clamped by the clamping part 13 inside the freeze dryer, and the second detection probe 5 is inserted into the first rubber plug 7 on the bottle cap of the freeze-drying bottle 3. The implementation steps can be used to install or unscrew the bottle cap and the freeze-drying bottle 3 according to the implementation steps.

[0037] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention is disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technician familiar with this profession can make some changes or modifications to equivalent embodiments of equivalent changes by using the technical content disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modifications, equivalent changes and modifications made to the above embodiments according to the technology of the present invention are all within the scope of the technical solution of the present invention without departing from the content of the technical solution of the present invention.

Claims

1. A freeze dryer, characterized in that: including a refrigeration system (9); A multi-point monitoring device for each plate layer of a freeze dryer, comprising a terminal (1) and a partition layer (2) located inside the freeze dryer, wherein the partition layer (2) in the freeze dryer has at least one layer, and the partition layer (2) accommodates a plurality of freeze-dried bottles (3) for placing samples; the terminal (1) is characterized in that: a first detection probe (4) for detecting the partition layer (2) and a second detection probe (5) for detecting the temperature inside the freeze-dried bottle (3) are connected; and a microprocessor chip (6) for controlling the first detection probe (4) and the second detection probe (5) to start detection is provided inside the terminal (1); The freeze-drying bottle (3) is provided with a first rubber stopper (7), the first rubber stopper (7) is provided with an opening, and the second detection probe (5) can extend into the interior of the first rubber stopper (7) along the opening; A first refrigeration unit (10) is provided inside the freeze dryer, and a second refrigeration unit (11) is provided on a partition in each partition layer (2). The first refrigeration unit (10) is used for refrigeration inside the freeze dryer, and the second refrigeration unit (11) is used for refrigeration of the freeze-dried bottles (3) placed on the partition in each partition layer (2). The first refrigeration unit (10) and the second refrigeration unit (11) are respectively connected to the refrigeration system (9) via electrical signals. The partition layer (2) in the freeze dryer is connected to the freeze dryer in a drawer-type movable manner; and inner groove positions (12) for placing freeze-dried bottles (3) are arranged in an array on the partitions in the partition layer (2); the second refrigeration unit (11) is distributed among the inner groove positions (12) on the partitions, and performs freeze-drying work for the freeze-dried bottles (3) placed in the inner groove positions (12).

2. The freeze dryer according to claim 1, characterized in that: The opening is arranged in the middle of the first rubber plug (7).

3. The freeze dryer according to claim 1, characterized in that: The terminal (1) is provided with a detection display screen (8), and a plurality of data displays for visually observing each partition layer (2) and each freeze-drying bottle (3) are distributed on the detection display screen (8).

4. The freeze dryer according to claim 1, wherein: The first refrigeration unit (10) is configured as a refrigeration pipe or a refrigeration box; the second refrigeration unit (11) is configured as a semiconductor refrigeration plate.

5. The freeze dryer according to claim 1, characterized in that: A clamping piece (13) for clamping the first detection probe (4) is provided on the inner wall of the freeze dryer.

6. The freeze dryer according to claim 5, characterized in that: A second rubber plug (14) for the first detection probe (4) and the second detection probe (5) to extend into is provided on the freeze dryer wall, and an opening is also provided on the second rubber plug (14).

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