Biopsy sampling device

Abstract

The present invention discloses a biopsy sampling device, in which a negative pressure tube and a cutting piece are movably arranged on a sampling main body. When it is necessary to operate on a lesion tissue, a part of the lesion tissue is aspirated through the suction port of the negative pressure tube, and the cutting piece moves on the sampling main body to close the sampling opening, so as to separate the tissue. The cutting piece can be operated repeatedly, and the fragmented samples collected can be continuously obtained through the negative pressure tube. Larger tissue samples can be drawn out of the sampling main body together with the negative pressure tube, shortening the sampling time and expanding the scope of use of the device.

Description

Technical Field

[0001] The present invention relates to the technical field of biopsy sampling, and particularly to a biopsy sampling device. Background Art

[0002] Tumors are diseases that seriously endanger human health and life. Since some tumors do not have typical imaging features, diagnosis is relatively difficult, and correct diagnosis requires a combination of clinical, pathological, etc. Among them, the puncture biopsy technique is the main way to obtain a pathological diagnosis. At present, endoscopic examination, as an auxiliary diagnostic method, has been widely used in clinical practice. A biopsy sampling device is a special surgical instrument for the puncture biopsy technique. The biopsy sampling device enters the patient's body through the channel of the endoscope to clamp the tissue of the lesion site, and then performs pathological analysis on the clamped tissue to confirm the disease.

[0003] Existing biopsy sampling devices generally include biopsy puncture needles, biopsy sampling forceps, etc. Taking the biopsy sampling forceps as an example, it adjusts the position of the endoscope and uses the biopsy sampling forceps to cut a part of the lesion tissue once. Each operation requires removing the biopsy sampling forceps to obtain the collected sample. For example, the invention patent CN201820287517.7 discloses a flexible ureteroscope biopsy forceps, which includes a flexible tube, a handle, a push rod, and a front-end biopsy forceps; the flexible tube is installed on the right side of the handle; the handle and the flexible tube are provided with axially circular holes in the center, and a slideway is installed in the circular hole; the push rod is installed on the slideway and moves axially along the slideway; the front-end biopsy forceps are installed at the right end of the push rod and include a puncture needle and a hook forceps; the puncture needle includes a needle tip and a biopsy tissue storage groove, and the needle tip is on the right side of the biopsy tissue storage groove. It has the advantages of simple instrument manufacturing process, operability under direct vision, and good safety, etc. However, each biopsy requires removing the biopsy sampling forceps, and only one sample can be collected. The size of the sample is also limited by the size of the biopsy tissue storage groove, and for some tissues, incomplete cutting may occur, which may cause the dissemination and implantation of tumor cells; moreover, the method of using the hook forceps to cut the tissue will cause great damage to the integrity of the sample tissue, and the cutting edges of the remaining tissue often tear and break, affecting the vision of subsequent operations. For the biopsy sampling of larger lesion tissues or multiple lesion tissues, repeated operations are required, and the working efficiency is relatively low.

[0004] To solve the problem that the biopsy forceps need to be taken out for each biopsy sampling so that continuous biopsies can be performed. For example, the invention patent CN201922084987.0 discloses an endoscopic biopsy forceps that can clamp multiple pieces of pathological tissues, including a forceps body and forceps teeth. The forceps body is communicated with a catheter. Mounting seats are arranged on both sides of the forceps body. Each forceps tooth is hinged to the mounting seat through a hinge, and each hinge is connected to a wire. The wire sequentially passes through the forceps body and the catheter. An opening is also arranged at the upper end of the forceps body, and a filter screen is arranged at the connection of the opening and the forceps body. By pulling the wire to drive the forceps teeth to close, a piece of pathological tissue can be clamped. Then, by pulling the wire again to open the forceps teeth, the pathological tissue falls into the filter screen at the opening, realizing that multiple samples can be clamped in one operation to improve work efficiency. However, it is necessary to suck the clamped sample into the filter screen through the catheter, so the inner diameter of the catheter needs to be set larger. Otherwise, the sample tissue will be broken and deformed, affecting pathological diagnosis. Therefore, it is not suitable for the operation environments of some endoscopes with relatively narrow channels (such as ureteroscopes, cystoscopes, etc.).

[0005] The purpose of the present invention is to provide a biopsy sampling device to solve at least one of the above technical problems. Summary of the Invention

[0006] In view of the above analysis, the present invention proposes a biopsy sampling device to solve the deficiencies of the prior art.

[0007] The present invention is mainly realized through the following technical solutions:

[0008] A biopsy sampling device, comprising:

[0009] A housing having an instrument channel that extends from a first end of the housing to a second end of the housing;

[0010] A sampling main body that is cooperatively inserted into the instrument channel and has a receiving space, and a sampling opening is provided on the receiving space;

[0011] A negative pressure tube that is movably arranged on the sampling main body and has a suction part corresponding to the second end. The suction part is arranged in the receiving space, and a suction opening is provided on the suction part beside the sampling opening;

[0012] A cutting piece that is movably installed on the sampling opening to open or close the sampling opening.

[0013] The negative pressure tube and the cutting piece are movably arranged on the sampling main body. When operating on the lesion tissue, a part of the lesion tissue is aspirated through the suction port of the negative pressure tube, and the cutting piece moves on the sampling main body to close the sampling opening, so as to separate the tissue and make the sample tissue fall into the accommodating space. The cutting piece can be operated repeatedly, and the fragmented samples collected can be continuously obtained through the negative pressure tube. Larger tissue samples can be drawn out of the sampling main body together with the negative pressure tube. When adsorbing larger tissues, there is no need to take out the whole biopsy sampling device, and only need to reinsert the negative pressure tube, which shortens the sampling time and expands the use range of the device.

[0014] Further, it further includes a driving member installed on the cutting piece.

[0015] Further, the cutting piece is installed on the negative pressure tube.

[0016] Further, a guiding groove is provided on the sampling main body near the sampling opening, and the cutting piece is slidably installed on the guiding groove.

[0017] Further, the sampling main body includes a hollow sleeve. One end of the hollow sleeve is provided with a sealing plate, and the other end is provided with an open part. An opening is provided on one side of the hollow sleeve to form a sampling opening cooperating with the cutting piece at least at the second end.

[0018] Further, the opening extends from the sealing plate to the open part, so as to form a sampling opening at the second end and a collection opening at the first end.

[0019] Further, a positioning seat is provided on the cutting piece, and the negative pressure tube is installed on the positioning seat.

[0020] Further, the suction port is a flared port.

[0021] Further, a pressure regulator is installed on the negative pressure tube.

[0022] Further, there is a gap between the cutting piece and the sealing plate.

[0023] The beneficial effects of the technical solution of the present invention compared with the prior art are:

[0024] The biopsy sampling device provided by the present invention uses a cutting piece for cutting. The surface of the cut sample is relatively flat, which will not cause visual interference to subsequent operations. After cutting, the cutting piece is used to seal the sampling opening to ensure the integrity of the sample and prevent sample fragments from falling off from the sampling opening during the transportation of the sample by the negative pressure tube, resulting in the dissemination and implantation of tumor cells. For larger lesion tissues, the sample tissue does not need to pass through the negative pressure tube, which reduces the requirement for the inner diameter size of the negative pressure tube and expands the application range of the device. It is particularly suitable for biopsy operations in the use environments such as ureteroscopes and cystoscopes. For multiple fragmented lesion tissues, by adjusting the cutting piece, the sample is continuously sucked from inside the negative pressure tube to the outside of the body without removing the biopsy sampling device, shortening the sampling time and improving work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0026] Figure 1 FIG. 1 is a schematic structural diagram (1) of Embodiment 1 of the biopsy sampling device provided by the embodiment of the present invention;

[0027] Figure 2 FIG. 2 Figure 1 is a schematic diagram of the state of the biopsy sampling device and the cut lesion tissue;

[0028] Figure 3 FIG. 3 Figure 1 is a schematic structural diagram of the cutting piece;

[0029] Figure 4 FIG. 4 is a schematic structural diagram of Embodiment 2 of the biopsy sampling device provided by the embodiment of the present invention;

[0030] Figure 5 FIG. 5 Figure 4 is a schematic structural diagram of the negative pressure tube and the cutting piece in FIG. 4.

[0031] The reference numerals are as follows:

[0032] 1. housing, 1a. instrument channel, 1b. first end, 1c. second end, 2. sampling main body, 2a. accommodating space, 2b. sampling opening, 2c. guiding groove, 2d. collecting opening, 21. hollow sleeve, 21a. open part, 22. sealing plate, 3. negative pressure tube, 31. suction part, 31a. suction port, 4. cutting piece, 5. driving member, 6. positioning seat, 7. lesion tissue. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0033] To enable those skilled in the art to better understand the present invention and thus more clearly define the scope of protection of the present invention, the present invention will be described in detail below with respect to certain specific embodiments of the present invention. It should be noted that the following are only some specific embodiments of the concept of the present invention and only a part of the embodiments of the present invention. The specific and direct descriptions of the relevant structures are only for the convenience of understanding the present invention, and each specific feature does not of course and directly limit the scope of implementation of the present invention. Routine selections and substitutions made by those skilled in the art under the guidance of the concept of the present invention shall be regarded as being within the scope of protection required by the present invention.

[0034] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0035] Embodiment 1

[0036] For a relatively large lesion tissue 7, in order to avoid the limitation of the inner diameter of the negative pressure tube 3 affecting its scope of use, it is impossible to directly extract through the negative pressure tube 3. Therefore, the vacuum negative pressure adsorption effect of the negative pressure tube 3 is selected to suck the sample tissue and take it out of the body.

[0037] Please refer to Figure 1 As shown, the biopsy sampling device provided by the present invention is particularly suitable for use in the operating environments of cystoscopes and ureteroscopes (for ureteroscopes, the diameter of the lesion tissue 7 ≤ 1.5 mm).

[0038] The biopsy sampling device includes: a housing 1, a sampling main body 2, a negative pressure tube 3, a cutting piece 4 and a driving member 5. The housing 1 has an instrument channel 1a, and the instrument channel 1a extends from the first end 1b of the housing 1 to the second end 1c of the housing 1. The sampling main body 2 is cooperatively disposed in the instrument channel 1a and has a receiving space 2a, and a sampling opening 2b is provided on the receiving space 2a.

[0039] The negative pressure tube 3 is movably disposed on the sampling main body 2 and can continuously perform sampling operations. By extracting the negative pressure tube 3, the sample tissue can be smoothly taken out. There is no need to withdraw the entire biopsy sampling device and re-enter it. For a relatively large lesion tissue 7, only the negative pressure tube 3 needs to be re-inserted to continuously perform the resection operation of the lesion tissue, which will not increase the burden on the patient, improve the surgical stability and shorten the operation time.

[0040] The negative pressure tube 3 has a suction part 31 corresponding to the second end 1c. The suction part 31 is arranged in the accommodation space 2a, and a suction port 31a is provided on the suction part 31 beside the sampling opening 2b. A pressure regulator is installed on the negative pressure tube 3 to control its negative pressure value, that is, the vacuum degree. The pressure regulator is preferably a throttle valve. By hierarchically setting the vacuum degree in the negative pressure tube 3, appropriate vacuum degrees can be selected according to different sample tissues to be obtained (distinguished according to parameters such as sample size and the position of the sample tissue), so as to balance the negative pressure suction efficiency and ensure the integrity of the lesion tissue 7. Among them, the suction part 31 is located at one end of the negative pressure tube 3 for sucking the lesion tissue.

[0041] The cutting piece 4 is movably installed on the sampling opening 2b to open or close the sampling opening 2b. The driving member 5 is installed on the cutting piece 4 to facilitate manual adjustment of the cutting piece 4 outside the body.

[0042] In this embodiment, the shape of the cutting edge of the cutting piece 4 is not limited as long as the cutting operation can be achieved. Preferably, the cutting edge is inclined to facilitate the rapid excision of the lesion tissue 7; as Figure 3 shown, the driving member 5 is rod-shaped or handle-shaped and is detachably connected to the cutting piece 4, which is convenient for replacing the cutting piece 4. Specifically, forms such as pin connection and snap connection are adopted.

[0043] The negative pressure tube 3 and the cutting piece 4 can independently adjust their positions respectively. By adjusting the position of the negative pressure tube 3 in the accommodation space 2a, its relative position to the sampling opening 2b can be seen under the endoscope, and the corresponding negative pressure value can be adjusted (adjusted according to the size of the sample tissue to be extracted), which is convenient for the adsorption operation; by adjusting the position of the cutting piece 4, the size of the sampling opening 2b can be adjusted for different sizes of sample tissues to be extracted.

[0044] Preferably, the sampling main body 2 includes a hollow sleeve 21. One end of the hollow sleeve 21 is provided with a sealing plate 22, and the other end is provided with an open part 21a. An opening is arranged on one side of the hollow sleeve 21 to form at least a sampling opening 2b cooperating with the cutting piece 4 at the second end 1c. The sample tissue is adsorbed by the negative pressure tube 3, and the cutting piece 4 moves to cover the sampling opening 2b at the second end 1c, so that the accommodation space 2a of the sampling main body 2 forms a relatively closed space in the body, enabling the negative pressure tube 3 to smoothly transport the cut sample tissue to the outside of the body, and at the same time, the negative pressure will not be damaged by the uncut tissue in the body.

[0045] In this embodiment, the suction port 31a is disposed opposite to the sealing plate 22, facilitating the suction of more tissues into the accommodation space 2a and preventing the sample tissues cut by the cutting blade 4 from being too small. The hollow sleeve 21 and the sealing plate 22 are integrally formed, and the guiding groove 2c is located between the opening and the sealing plate 22, so that there is a gap between the sealing plate 22 and the cutting blade 4 to avoid damaging the cutting edge. The position of the cutting blade 4 can be observed under the endoscope to avoid accidental tissue damage. The opening extends from the sealing plate 22 to the open portion 21a to form a sampling opening 2b at the second end 1c and a collection opening 2d at the first end 1b. The sampling opening 2b and the collection opening 2d are separated by the cutting blade 4. When the cutting blade 4 closes the sampling opening 2b, only the collection opening 2d of the hollow sleeve 21 is in an open state.

[0046] The design of the sampling body 2 reduces the volume of the sampling body 2. At the same time, the driving member 5 and the negative pressure tube 3 extend from the open portion 21a, making it easier to take out the negative pressure tube 3 and the sample tissues from the collection opening 2d, further ensuring the integrity of the sample tissues and reducing the surgical difficulty. Among them, the accommodation space 2a is an accommodation groove, and the cross-sections of the hollow sleeve 21, the accommodation groove and the sealing plate 22 are approximately semi-circular arcs, ensuring the width of the sampling opening 2b, reducing the volume occupied by the hollow sleeve 21, facilitating the negative pressure tube 3 to more stably suck the lesion tissue 7, and facilitating the cutting blade 4 to perform cutting.

[0047] Among them, the suction port 31a is located at the outer end of the negative pressure tube 3. The negative pressure tube 3 can be cylindrical, the end face of the suction port 31a is in a flared shape, and the inner wall of the negative pressure tube 3 is smooth and non-sticky. For the convenience of moving the negative pressure tube 3, the outer diameter of the negative pressure tube 3 is smaller than the radius of the accommodation space 2a. The shape of the negative pressure tube 3 is not limited to the above structure, and it can also be adapted to the shape of the accommodation space 2a to make the best use of the internal space of the accommodation space 2a and improve the suction efficiency of the negative pressure tube 3.

[0048] In this embodiment, the sampling body 2 is provided with a guiding groove 2c disposed close to the sampling opening 2b, preferably on the two opposite inner side walls of the sampling opening 2b. The cutting blade 4 is slidably mounted on the guiding groove 2c to move along the length direction of the sampling body 2. The guiding groove 2c extends from the open portion 21a to the sealing plate 22, facilitating the installation of the cutting blade 4 and guiding its moving direction, avoiding accidental tissue damage during operation. After cutting, the cutting blade 4 closes the sampling opening 2b to prevent the sample fragments from falling from the sampling opening 2b, ensuring the safety and reliability of the device during use.

[0049] Such as Figure 2As shown in the figure, during use, bring the biopsy sampling device close to the lesion tissue 7. Hold the drive handle at the first end 1b of the housing 1 and move it outward from the instrument channel 1a. Adjust the cutting blade 4 to open the sampling opening 2b to an appropriate length (determined according to the size of the sample tissue to be cut). Cover part of the lesion tissue 7 with the accommodation groove at the sampling opening 2b. Hold the drive handle at the first end 1b of the housing 1 and move it into the instrument channel 1a. Adjust the cutting blade 4 to cut the lesion tissue 7 at the sampling opening 2b. Then close the sampling opening 2b and collect the sample tissue at the collection opening 2d. If re-sampling is required, insert the negative pressure tube 3 into the hollow sleeve 21 for re-sampling. After sampling, take out the housing 1.

[0050] Embodiment 2

[0051] For multiple fragmented lesion tissues 7, they can be directly extracted through the negative pressure tube 3. As Figure 4 、 5 shown, the present invention also provides another biopsy sampling device. The cutting blade 4 is installed on the negative pressure tube 3. The cutting blade 4 and the negative pressure tube 3 can move integrally along the length direction of the sampling main body 2. The negative pressure tube 3 is cylindrical, and the end face of the suction port 31a is flared. The inner wall of the negative pressure tube 3 is smooth and non-sticky. Adjust the negative pressure value of the negative pressure tube 3 (theoretically less than that in Embodiment 1 and adjusted according to the size of the sample tissue to be extracted) to facilitate the transportation of the sample tissue under negative pressure.

[0052] In the biopsy sampling of fragmented lesion tissues, only the stroke of the cutting blade 4 needs to be operated, and it can be continuously operated without taking out the negative pressure tube 3 until enough sample tissues are collected, which can effectively shorten the operation time and improve the operation efficiency and the success rate of pathological diagnosis.

[0053] Preferably, a positioning seat 6 is provided on the cutting blade 4, and the negative pressure tube 3 is installed on the positioning seat 6.

[0054] In this embodiment, the positioning seat 6 is provided on the back side of the cutting blade 3, and a clamping groove is provided on the positioning seat 6. The negative pressure tube 3 is welded to the clamping groove.

[0055] The above are only the preferred embodiments of the present invention. The protection scope of the present invention is not limited to the above embodiments. All technical solutions within the idea of the present invention belong to the protection scope of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and retouches should also be regarded as the protection scope of the present invention.

Claims

1. A biopsy sampling device, characterized in that, Comprising: A housing (1) having an instrument channel (1a) extending from a first end (1b) of the housing (1) to a second end (1c) of the housing (1); A sampling body (2) fitted through the instrument channel (1a) and having an accommodation space (2a) provided with a sampling opening (2b); A negative pressure tube (3) movably disposed on the sampling body (2) and having a suction portion (31) corresponding to the second end (1c), the suction portion (31) being disposed in the accommodation space (2a), and a suction opening (31a) being provided on the suction portion (31) beside the sampling opening (2b); A cutting piece (4) movably mounted on the sampling opening (2b) to open or close the sampling opening (2b); A guiding groove (2c) is provided on the sampling body (2) near the sampling opening (2b), and the cutting piece (4) is slidably mounted on the guiding groove (2c); The sampling body (2) includes a hollow sleeve (21) having a sealing plate (22) at one end and an open end (21a) at the other end, and an opening is provided on one side of the hollow sleeve (21) to form at least at the second end (1c) a sampling opening (2b) cooperating with the cutting piece (4); The opening extends from the sealing plate (22) to the open end (21a) to form a sampling opening (2b) at the second end (1c) and a collection opening (2d) at the first end (1b).

2. The biopsy sampling device according to claim 1, wherein: It further includes a driving member (5) mounted on the cutting piece (4).

3. The biopsy sampling device according to claim 1, characterized in that: The cutting piece (4) is mounted on the negative pressure tube (3).

4. The biopsy sampling device according to claim 3, wherein: A positioning seat (6) is provided on the cutting piece (4), and the negative pressure tube (3) is mounted on the positioning seat (6).

5. The biopsy sampling device according to any one of claims 2-4, characterized in that: The suction opening (31a) is a flared opening.

6. The biopsy sampling device according to claim 1, wherein: A pressure regulator is mounted on the negative pressure tube (3).

7. The biopsy sampling device according to any one of claims 1 to 3, characterized in that: There is a gap between the cutting piece (4) and the sealing plate (22).

Images