A device for making a scald model of experimental mice

Abstract

The present invention provides a device for making a scald model of an experimental mouse; it comprises a base plate, a main machine, a main machine support and fixing frame, and a fixing device; the lower end of the main machine support and fixing frame is movably mounted on the base plate, the main machine is hoisted on the main machine support and fixing frame, and the fixing device is movably arranged on the base plate. The present invention uses a fixing device to fix the experimental mouse on the base plate, and then controls the main machine on the main machine support and fixing frame to enter a working state, so as to realize accurate making of a scald model at a designated part of the experimental mouse. The process does not require excessive manual participation, and the degree of automation is improved. Since the making of the scald model is automated, the consistency of the model making is also high.

Description

Technical Field

[0001] The invention relates to the technical field of basic medical experiments and animal experiments, and in particular to a device for making a scald model of experimental mice. Background Art

[0002] Scald is a common sudden disease in life, which brings great pain to patients, and even causes disfigurement or death in severe cases, and has great psychological trauma to patients. Therefore, it is particularly important to study the pathogenesis of scald and develop therapeutic drugs. Experimental rats and mice are widely used in scald research. The preparation methods of rat and mouse scald models commonly used at present include: solid scald method, liquid scald method, steam scald method, etc. Although these methods can simulate the occurrence of scald well, the homogeneity of the model is poor, and the stability of experimental data cannot be guaranteed. Summary of the invention

[0003] In order to at least solve the technical problems existing in the above-mentioned background technology, the present invention provides a device for making an experimental mouse scald model to solve the problem of uniformity in modeling rat and mouse scald models, thereby reducing experimental errors, improving the accuracy of experimental data, and providing a solid and reliable foundation for the study of the pathogenesis of scalds and the development of therapeutic drugs.

[0004] A device for making a scald model of an experimental mouse comprises a bottom plate, a main machine, a main machine supporting and fixing frame, and a fixing device; the lower end of the main machine supporting and fixing frame is movably mounted on the bottom plate, the main machine is hoisted on the main machine supporting and fixing frame, and the fixing device is movably arranged on the bottom plate.

[0005] Preferably, the device further comprises a breathing mask, wherein the breathing mask is arranged at one end of the base plate and connected to a gas outlet of a gas anesthesia machine.

[0006] Preferably, the breathing mask is made of soft material.

[0007] Preferably, the device further comprises an interaction module, wherein the interaction module is arranged at one end of the base plate and is arranged opposite to the breathing mask.

[0008] Preferably, the interaction module includes an input part and a display part.

[0009] Preferably, the fixing device comprises two front positioning parts, two rear positioning parts, and a first elastic band respectively connecting the two front positioning parts, and a second elastic band respectively connecting the two rear positioning parts;

[0010] Furthermore, the front positioning portion and the rear positioning portion are both made of magnetic materials, and the upper surface of the bottom plate is made of a material that can be attracted by magnets.

[0011] Preferably, the fixing device further comprises a third elastic band, and two ends of the third elastic band are respectively connected to the first elastic band and the second elastic band.

[0012] Preferably, the third elastic band includes a solid portion and a hollow portion, and the hollow portion is located in the middle of the third elastic band and is wrapped by the solid portion.

[0013] Preferably, the host includes a main control chip, a driving motor, a movable shaft, a heating head and a head sleeve; the driving motor is arranged in the head sleeve, the driving motor is connected to the movable shaft, and the movable shaft is connected to the heating head; the main control chip is electrically connected to the driving motor.

[0014] Preferably, the host also includes a pressure sensor, a temperature sensor, a positioning light emitter, and a spring; the pressure sensor, temperature sensor, and positioning light emitter are all electrically connected to the main control chip; the temperature sensor is arranged in the heating head, and the two ends of the spring are respectively connected to the movable shaft and the heating head.

[0015] In the scheme of the present invention, the present invention uses a fixing device to fix the experimental mouse on the bottom plate, and then controls the main machine on the main machine support fixing frame to enter the working state, so as to realize the accurate production of the burn model at the specified part of the experimental mouse. This process does not require much manual participation, and improves the degree of automation. Since the production of the burn model is automated, the consistency of the modeling is also high. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0017] Figure 1 It is a first side view of the structure of a device for making a scald model of an experimental mouse disclosed in an embodiment of the present invention;

[0018] Figure 2 It is a second side view of the structure of a device for making a scald model of an experimental mouse disclosed in an embodiment of the present invention;

[0019] Figure 3 It is a top view of the structure of a device for making a scald model of an experimental mouse disclosed in an embodiment of the present invention;

[0020] Figure 4 is a schematic diagram of the structure of a fixing device disclosed in an embodiment of the present invention;

[0021] Figure 5 is another structural schematic diagram of the fixing device disclosed in the embodiment of the present invention;

[0022] Figure 6 is a schematic structural diagram of a third elastic band (405) disclosed in an embodiment of the present invention;

[0023] Figure 7 is a schematic diagram of the structure of a host (2) disclosed in an embodiment of the present invention;

[0024] Figure 8 It is a schematic diagram of the functional principle of the host (2) disclosed in the embodiment of the present invention. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] The words "first, second, third, etc." or module A, module B, module C and the like in the specification and claims are used only to distinguish similar objects and do not represent a specific ordering of the objects. It is understandable that the specific order or sequence can be interchanged where permitted so that the embodiments of the invention described herein can be implemented in an order other than that illustrated or described herein.

[0027] The term "comprising" as used in the description and claims should not be interpreted as being limited to what is listed thereafter; it does not exclude other elements or steps. Therefore, it should be interpreted as specifying the presence of the features, integers, steps or components mentioned, but does not exclude the presence or addition of one or more other features, integers, steps or components and groups thereof. Therefore, the expression "a device comprising means A and B" should not be limited to a device consisting of components A and B only.

[0028] References to "one embodiment" or "an embodiment" in this specification mean that a particular feature, structure, or characteristic described in conjunction with the embodiment is included in at least one embodiment of the present invention. Therefore, the phrases "in one embodiment" or "in an embodiment" appearing in various places in this specification do not necessarily refer to the same embodiment, but may refer to the same embodiment. In addition, in one or more embodiments, the particular features, structures, or characteristics can be combined in any appropriate manner, as would be apparent to one of ordinary skill in the art from this disclosure.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. In the event of any inconsistency, the meanings described in this specification or derived from the contents recorded in this specification shall prevail. In addition, the terms used herein are only for the purpose of describing the embodiments of the present invention and are not intended to limit the present invention.

[0030] See also Figure 1-3 The present invention provides a device for making a scald model for an experimental mouse. As shown in the figure, a device for making a scald model for an experimental mouse according to an embodiment of the present invention comprises a base plate (1), a main machine (2), a main machine support and fixing frame (3), and a fixing device (4); the lower end of the main machine support and fixing frame (3) is movably mounted on the base plate (1), the main machine (2) is hoisted on the main machine support and fixing frame (3), and the fixing device (4) is movably arranged on the base plate (1).

[0031] In the embodiment of the present invention, as described in the background technology, the existing scald model making methods such as solid scald method, liquid scald method, steam scald method, etc. in the prior art can simulate the occurrence of scald well, but the model making process mainly relies on the subjective judgment and model making experience of the operator, resulting in poor consistency of model making. In view of this, the present invention designs the above-mentioned experimental mouse scald model making device, using a fixing device (4) to fix the experimental mouse on the bottom plate (1), and then controlling the main machine (2) on the main machine support fixing frame (3) to enter the working state, so as to realize the accurate making of the scald model at the specified part of the experimental mouse, and the process does not require too much manual participation, thereby improving the degree of automation. Since the scald model making is automated, the consistency of model making is also high.

[0032] The bottom plate (1) may be provided with a track groove and a plurality of mounting holes (e.g., threaded holes, non-threaded holes) to support the movable mounting of the host support fixing frame (3), that is, the position of the host support fixing frame (3) on the bottom plate (1) may be changed, which is conducive to aligning the host (2) on the host support fixing frame (3) with different parts of the experimental mouse.

[0033] Furthermore, the device also comprises a breathing mask (5), wherein the breathing mask (5) is arranged at one end of the base plate (1), and the breathing mask (5) is connected to the gas outlet of the gas anesthesia machine.

[0034] In the embodiment of the present invention, refer to Figure 1 As shown, a breathing mask (5) is further integrated on the bottom plate (1) to facilitate operators to perform anesthesia on the experimental mice, to prevent the experimental mice from twisting due to thermal stimulation during the scald modeling process, and to ensure the accuracy of the scald modeling.

[0035] Furthermore, the breathing mask (5) is made of soft material.

[0036] In the embodiment of the present invention, the breathing mask (5) can be made of soft materials, such as plastic, rubber, silicone, etc. The breathing mask (5) generally has two openings, the large opening is used to connect with the mouth of the experimental mouse, and the small opening is used to connect with the outlet pipe connected to the outlet of the gas anesthesia machine.

[0037] Furthermore, the device also includes an interaction module (6), which is arranged at one end of the base plate (1) and is arranged opposite to the breathing mask (5).

[0038] Furthermore, the interaction module (6) comprises an input part and a display part.

[0039] In the embodiment of the present invention, refer to Figure 1 , Figure 3 As shown, an interactive module (6) is also provided at the other end of the bottom plate (1), which includes an input part and a display part (not shown in the figure). The input part supports the operator to input relevant parameters for making the scald model, for example, it may include a start / stop button, an emergency stop button, a function switching button, a temperature setting button, an emergency stop button, etc.; the display part is used to display the input / output information corresponding to the above function buttons, and a screen of a type such as TFT, TFD, UFB, STN, OLED and AMOLED may be selected; and the input part and the display part may be provided in an integrated manner, for example, a touch screen is used.

[0040] Furthermore, the fixing device (4) comprises two front positioning parts (401), two rear positioning parts (402), and a first elastic band (403) respectively connected to the two front positioning parts (401), and a second elastic band (404) respectively connected to the two rear positioning parts (402);

[0041] Furthermore, the front positioning portion (401) and the rear positioning portion (402) are both made of magnetic materials, and the upper surface of the bottom plate (1) is made of a material that can be attracted by magnets.

[0042] In the embodiment of the present invention, refer to Figure 4 As shown, the fixing device of the present invention comprises two parts, the front part is used to fix the front limbs, head or incisors of the experimental mouse, and the rear part is used to fix the rear limbs, buttocks and other parts of the experimental mouse. The front and rear parts are used in combination to achieve a relatively stable fixation of the experimental mouse on the base plate (1), and anesthesia treatment can be used to obtain a better fixation effect.

[0043] In addition, the fixing device (4) of the present invention can be connected to the bottom plate (1) by magnetic attraction to achieve fixation, and the magnetic attraction positions of the front positioning part (401) and the rear positioning part (402) can be freely adjusted, so as to facilitate the fixation of experimental mice of different sizes. The magnetically attracted material can be iron, nickel, cobalt, or alloys of the above materials.

[0044] Furthermore, the present invention can also configure the bottom end of the mainframe support and fixing frame (3) to be made of magnetic material, thereby facilitating adjustment of the position of the mainframe support and fixing frame (3) on the bottom plate (1).

[0045] Furthermore, the fixing device (4) further comprises a third elastic band (405), and two ends of the third elastic band (405) are respectively connected to the first elastic band (403) and the second elastic band (404).

[0046] In the embodiment of the present invention, refer to Figure 5 As shown, based on the above-mentioned embodiment, the present invention further adds a third elastic band (405) to the fixing device, which can fix the body (mainly the spine) of the experimental mouse and obtain a better fixing effect.

[0047] Furthermore, the third elastic band (405) comprises a solid portion (4051) and a hollow portion (4052), wherein the hollow portion (4052) is located in the middle of the third elastic band (405) and is wrapped by the solid portion (4051).

[0048] In the embodiment of the present invention, refer to Figure 6 As shown, based on the aforementioned embodiment, the present invention further provides a hollow portion (4052) in the middle of the third elastic band (405). The presence of the hollow portion (4052) allows the body part of the spine of the experimental mouse to enter, thereby reducing the probability of the third elastic band (405) slipping off the experimental mouse, and further enhancing the fixing effect on the experimental mouse.

[0049] In addition, the third elastic band (405) can also be configured to have different elastic properties, for example, the elastic coefficient of the portion of the solid portion (4051) located at the edge of the hollow portion (4052) is the smallest, while the elastic coefficient of the portion of the solid portion (4051) away from the hollow portion (4052) gradually increases. With such a configuration, the solid portion (4051) at the hollow portion (4052) can be made looser, which is beneficial for the spine portion of the experimental mouse to enter. When the experimental mouse enters too much (for example, the experimental mouse is too obese, or struggles and twists, etc.), the outer ring of the solid portion (4051) is tighter, which can prevent the hollow portion (4052) from continuing to move downward, thereby preventing the third elastic band (405) from becoming unfastened and strengthening the fixation effect on the experimental mouse.

[0050] Furthermore, the host (2) comprises a main control chip (201), a driving motor (202), a movable shaft (203), a heating head (204) and a head sleeve (205); the driving motor (202) is arranged in the head sleeve (205), the driving motor (202) is connected to the movable shaft (203), and the movable shaft (203) is connected to the heating head (204); the main control chip (201) is electrically connected to the driving motor (202).

[0051] In the embodiment of the present invention, refer to Figure 7-8 As shown, the present invention uses an electric control method to control the heating head (204) to move to a designated part of the experimental mouse to produce a burn model.

[0052] Furthermore, the host (2) also includes a pressure sensor (206), a temperature sensor (207), a positioning light emitter (208), and a spring; the pressure sensor (206), the temperature sensor (207), and the positioning light emitter (208) are all electrically connected to the main control chip (201); the temperature sensor (207) is arranged in the heating head (204), and the two ends of the spring are respectively connected to the movable shaft (203) and the heating head (204).

[0053] In the embodiment of the present invention, refer to Figure 8 As shown, the movable shaft (203), spring, pressure sensor (206), temperature sensor (207), positioning light emitter (208), and heating head (204) in the present invention are combined into an integral head through a head sleeve (205), and the head moves up and down with the movable shaft (203), thereby achieving contact with the body of the experimental mouse.

[0054] The heating head (204) in the host (2) is filled with electric heating wires, and the temperature can be adjusted according to different experimental requirements; a temperature sensor (207) is provided in the heating head (204) for monitoring the temperature of the heating head (204) and feeding back to the main control chip (201) in real time to control the operation of the heating head (204); a pressure sensor (206) in the host is used to sense the pressure applied by the probe after contacting the animal's body, and feeding back to the main control chip (201) in real time, so that the main control chip (201) can control the temperature according to preset parameters. The working state of the driving motor (202) is adjusted to adjust the pressure exerted by the head on the animal; the positioning light emitter (208) is arranged on the head sleeve (205), and four positioning light emitters (208) can be arranged and distributed perpendicularly to each other. Before the scalding model is formed, the position of the scalding model can be used as a reference for the user according to the position of the infrared projection on the animal's body; the spring arranged at the rear of the heating head (204) can play a buffering role, reduce the impact force on the experimental mouse, and can also make the heating head (204) in close contact with the body part of the experimental mouse, thereby improving the modeling effect.

[0055] The working principle of the present invention is:

[0056] The operator places the experimental mouse (rat or mouse) that has been anesthetized by isoflurane in a prone position on a base plate (1), and then fixes its limbs, head, buttocks and even incisors with a fixing device (4); presses a breathing mask (5) on the head of the experimental mouse, starts the gas anesthesia machine, and the anesthetic gas is transmitted from the outlet pipe to the breathing mask (5) and is inhaled by the experimental mouse to maintain its anesthesia state. Manually push the host support fixing frame (3) to move the host (2) to the specified position. During this process, the operator can observe the relative position relationship between the host (2) and the experimental mouse by locating the light spot irradiated by the light emitter (208) on the experimental mouse to align the target scald position of the experimental mouse; input the temperature and other related parameters for scald modeling on the input part of the interactive module (6), check whether the input parameters are accurate through the display part, and touch the start button after confirmation. At this time, the host (2) starts working, and the heating head (204) gradually reaches the target scald position to achieve scald modeling. After the modeling is completed, the operator can touch the stop button, and the host (2) controls the heating head (204) to rise to the initial position. During the modeling process, the main control chip (201) is also used to monitor the temperature of the heating head (204) through the temperature sensor (207) and adjust it in time according to the preset rules.

[0057] Note that the above are only preferred embodiments of the present invention and the technical principles used. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments, and may also include more other equivalent embodiments without departing from the concept of the present invention, all of which belong to the scope of protection of the present invention.

Claims

1. A device for making a scald model of experimental mice, characterized in that: It comprises a base plate (1), a main machine (2), a main machine supporting and fixing frame (3), and a fixing device (4); the lower end of the main machine supporting and fixing frame (3) is movably mounted on the base plate (1), the main machine (2) is hoisted on the main machine supporting and fixing frame (3), and the fixing device (4) is movably arranged on the base plate (1); The fixing device (4) comprises two front positioning parts (401), two rear positioning parts (402), and a first elastic band (403) respectively connected to the two front positioning parts (401), and a second elastic band (404) respectively connected to the two rear positioning parts (402); Furthermore, the front positioning portion (401) and the rear positioning portion (402) are both made of magnetic materials, and the upper surface of the bottom plate (1) is made of a material that can be attracted by magnets; The fixing device (4) further comprises a third elastic band (405), and two ends of the third elastic band (405) are respectively connected to the first elastic band (403) and the second elastic band (404); The third elastic band (405) comprises a solid portion (4051) and a hollow portion (4052), wherein the hollow portion (4052) is located in the middle of the third elastic band (405) and is wrapped by the solid portion (4051); The elastic coefficient of the portion of the solid portion (4051) of the third elastic band (405) located at the edge of the hollow portion (4052) is the smallest, while the elastic coefficient of the portion of the solid portion (4051) away from the hollow portion (4052) gradually increases; The device further comprises a breathing mask (5), wherein the breathing mask (5) is arranged at one end of the base plate (1), and the breathing mask (5) is connected to the gas outlet of the gas anesthesia machine; The device further comprises an interaction module (6), wherein the interaction module (6) is arranged at one end of the base plate (1) and is arranged opposite to the breathing mask (5).

2. The device for making a scald model for experimental mice according to claim 1, characterized in that: The breathing mask (5) is made of soft material.

3. The device for making a scald model for experimental mice according to claim 2, characterized in that: The interaction module (6) comprises an input part and a display part.

4. The device for making a scald model for experimental mice according to claim 1, characterized in that: The host (2) comprises a main control chip (201), a driving motor (202), a movable shaft (203), a heating head (204) and a head sleeve (205); the driving motor (202) is arranged in the head sleeve (205), the driving motor (202) is connected to the movable shaft (203), and the movable shaft (203) is connected to the heating head (204); the main control chip (201) is electrically connected to the driving motor (202).

5. The device for making a scald model for experimental mice according to claim 4, characterized in that: The host (2) further comprises a pressure sensor (206), a temperature sensor (207), a positioning light emitter (208), and a spring; the pressure sensor (206), the temperature sensor (207), and the positioning light emitter (208) are all electrically connected to the main control chip (201); the temperature sensor (207) is arranged in the heating head (204), and the two ends of the spring are respectively connected to the moving shaft (203) and the heating head (204).

Images