Control method for sample detection in coagulation analyzer and coagulation analyzer

Abstract

The present application discloses a control method for sample detection in a coagulation analyzer and a coagulation analyzer. By configuring the sample rack in the coagulation analyzer into a plurality of wells and configuring the number of pre-heating positions in the pre-heating tray and the number of test positions in the test tray to be greater than the number of wells, when the coagulation analyzer performs detection of the first item, sampling and detection can be performed on the plurality of wells in batches, that is, sample addition, pre-heating, reagent addition, and cup discarding are performed on the reaction cup corresponding to each well in turn. Since the reagent added to the reaction cup is the first reagent, after adding the first reagent to a reaction cup, the first reagent can be continued to be used to add the first reagent to the next reaction cup without cleaning the first reagent needle, thereby reducing the time consumption caused by cleaning the first reagent needle, thereby improving the detection efficiency of the coagulation analyzer for the first sample on the first item.

Description

Technical Field

[0001] The present application relates to the field of coagulation analyzers, and in particular to a control method for sample detection in a coagulation analyzer and a coagulation analyzer. Background Art

[0002] Coagulation analyzer is a routine medical device that detects the content of various components in human blood, quantifies biochemical analysis results, and provides reliable numerical basis for clinical diagnosis of various diseases of patients. For example, the coagulation analyzer preheats the sample and then adds the corresponding reagent. After the reagent and sample fully react, the test results of the corresponding test items are obtained.

[0003] At present, a coagulation analyzer is usually required to perform multiple test items on a sample. In different test items, the reagents added to the sample are different. Therefore, after the coagulation analyzer completes one test item and before the next test item, the reagent needle used to add the reagent needs to be cleaned to avoid impurities in the reagent added to the sample.

[0004] Frequent cleaning of the reagent needle will obviously prolong the detection time, resulting in reduced detection efficiency of the coagulation analyzer for the sample. Summary of the invention

[0005] In view of this, the present application provides a control method for sample detection in a coagulation analyzer and a coagulation analyzer, which are used to solve the technical problem of low detection efficiency caused by frequent cleaning of reagent needles when the coagulation analyzer detects samples in the prior art. As follows:

[0006] The present application provides a control method for sample detection in a coagulation analyzer, wherein the coagulation analyzer comprises a plurality of sample racks, one of the sample racks comprises a plurality of wells, one of the wells is used to place a tube of sample, and the method comprises:

[0007] Controlling a first sample rack in the coagulation analyzer to move from a sample position to a sample suction position corresponding to a sample adding needle, wherein a first sample is placed in a hole of the first sample rack, and the first sample is used to detect a first item;

[0008] For each well in the first sample rack, the following processes are performed in sequence:

[0009] Controlling the sample adding needle in the coagulation analyzer to draw the first sample from the well position and add the first sample into the reaction cup at the sample arrangement position, wherein the number of the reaction cups is consistent with the number of the well positions;

[0010] Controlling the reaction cup to enter a pre-heating position in the pre-heating tray of the coagulation analyzer, so that the sample in the reaction cup enters a pre-heating state; the number of pre-heating positions in the pre-heating tray is greater than the number of holes in the sample rack;

[0011] When the duration of the reaction cup being in the preheating state reaches the preheating duration corresponding to the first item, controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer; the number of test positions in the test tray is greater than the number of holes in the sample rack;

[0012] Controlling a first reagent needle of the coagulation analyzer to add a first reagent corresponding to the first item into the reaction cup;

[0013] When the duration of adding the first reagent to the reaction cup reaches the test duration corresponding to the first item, the reaction cup is controlled to enter the cup discarding position.

[0014] Preferably, the above method further comprises, before controlling the first reagent needle to add the first reagent into the reaction cup corresponding to the first well in the first sample rack:

[0015] Determine whether a second sample in a second sample rack in the coagulation analyzer is used to detect a second item; the second sample rack is a sample rack that is moved to the sample suction position before the first sample rack, and the second item is different from the first item;

[0016] If the second sample in the second sample rack is used to detect the second item, the first reagent needle is cleaned.

[0017] In the above method, preferably, the coagulation analyzer corresponds to a time period for detection control, and the time period is 8.5 seconds;

[0018] Wherein, controlling the first sample rack in the coagulation analyzer to move from the sample position to the preset sample suction position includes:

[0019] At a first time point in a first time period, controlling a first sample rack in the coagulation analyzer to start moving from a sample position to a preset sample suction position, so that the first sample rack reaches the sample suction position at a second time point in a second time period, the second time period being a time period after the first time period;

[0020] Wherein, after controlling the sample adding needle to absorb the first sample from the last well in the first sample rack, the method further comprises:

[0021] At a third time point in a third time period, controlling the first sample rack to move from the sample suction position to the sample position, so that the first sample rack reaches the sample position at a fourth time point in the third time period;

[0022] The fourth time point is smaller than the first time point.

[0023] In the above method, preferably, the step of controlling the sample adding needle in the coagulation analyzer to draw the first sample from the hole and adding the first sample to the reaction cup at the sample arrangement position comprises:

[0024] At a fifth time point in the fourth time period, controlling the sample adding needle of the coagulation analyzer to start drawing the first sample from the well position and adding the first sample to the reaction cup at the sample discharging position, so that the first sample is added completely at a fifth time point in the fifth time period;

[0025] The fifth time period is a time period after the fourth time period, and after a fifth time point in the fifth time period, the sample adding needle can be used to absorb the corresponding first sample from other wells.

[0026] The above method, preferably, further comprises:

[0027] At a fifth time point in the fourth time period, a corresponding pre-heating position is configured for the hole position in the pre-heating tray, so that the pre-heating position starts to wait for the reaction cup corresponding to the hole position to enter from the fifth time point in the fourth time period;

[0028] After the reaction cup corresponding to the well position enters the testing position from the pre-heating position, the pre-heating position waits to be configured as the pre-heating position corresponding to other well positions.

[0029] In the above method, preferably, the cleaning of the first reagent needle comprises:

[0030] At the sixth time point of the sixth time period, the first reagent needle begins to be cleaned, so that the first reagent needle is completely cleaned at the sixth time point of the seventh time period;

[0031] The seventh time period is a time period after the sixth time period.

[0032] In the above method, preferably, when the duration of the reaction cup being in the preheating state reaches the preheating duration corresponding to the first item, before controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer, the method further includes:

[0033] At a seventh time point in the eighth time period, controlling the second reagent needle to add the second reagent corresponding to the first item into the reaction cup;

[0034] When the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the second reagent, the steps of: controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer;

[0035] Wherein, controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer comprises:

[0036] At an eighth time point in a ninth time period, the reaction cup begins to be moved from the pre-heating position to the testing position by using a transfer gripper, so that the reaction cup reaches the testing position at a ninth time point in the ninth time period.

[0037] Preferably, the above method further comprises, before controlling the second reagent needle to add the second reagent corresponding to the first item into the reaction cup corresponding to the first well in the first sample rack:

[0038] Determining whether the second sample in the second sample rack is used to detect a second item;

[0039] If the second sample in the second sample rack is used to detect the second item, the second reagent needle of the coagulation analyzer is started to be cleaned at the seventh time point of the tenth time cycle, so that the second reagent needle is cleaned at the seventh time point of the eighth time cycle, and the eighth time cycle is the time period after the tenth time cycle.

[0040] The above method, preferably, after controlling the first reagent needle of the coagulation analyzer to add the first reagent corresponding to the first item into the reaction cup, the method further comprises:

[0041] At the tenth time point in the eleventh time period, the reaction cup begins to be moved from the test position to the test mixing position by using a transfer gripper, so that the reaction cup reaches the test mixing position at the eleventh time point in the eleventh time period;

[0042] When the duration of the reaction cup being in the test mixing position reaches the mixing time corresponding to the first reagent, at the eleventh time point of the twelfth time period, the reaction cup is moved from the test mixing position to the test position by using a transfer gripper, so that the reaction cup reaches the test position at the twelfth time point of the twelfth time period;

[0043] Wherein, when the duration of the reaction cup being in the test position reaches the test duration corresponding to the first item, controlling the reaction cup to enter the cup discarding position includes:

[0044] At the thirteenth time point in the thirteenth time period, the reaction cup begins to be moved from the testing position to the cup discarding position by using a transfer gripper, so that the reaction cup reaches the cup discarding position at the fourteenth time point in the fourteenth time period.

[0045] The present application also provides a coagulation analyzer, comprising:

[0046] A plurality of sample racks, wherein one of the sample racks comprises a plurality of wells, and one of the wells is used to place a tube of sample;

[0047] Sample needle;

[0048] First reagent needle;

[0049] A plurality of reaction cups, wherein the number of the reaction cups is greater than the number of wells in the sample rack;

[0050] A pre-heating plate comprising a plurality of pre-heating positions, wherein the number of the pre-heating positions is greater than the number of wells in the sample rack;

[0051] A test tray comprising a plurality of test positions, wherein the number of the test positions is greater than the number of wells in the sample rack;

[0052] Lost cup position;

[0053] A controller, used to: control a first sample rack to move from a sample position to a preset sample suction position, wherein a first sample is placed in a hole of the first sample rack, and the first sample is used to detect a first item;

[0054] The controller sequentially executes the following processes for each well in the first sample rack:

[0055] Controlling the sample adding needle to absorb the first sample from the well position and add the first sample into the reaction cup at the sample arrangement position, the number of the reaction cups being consistent with the number of the well positions;

[0056] Controlling the reaction cup to enter a pre-heating position in the pre-heating tray so that the sample in the reaction cup enters a pre-heating state;

[0057] When the duration of the reaction cup being in the preheating state reaches the preheating duration corresponding to the first item, controlling the reaction cup to enter a testing position in the test tray;

[0058] controlling the first reagent needle to add the first reagent corresponding to the first item into the reaction cup;

[0059] When the duration of the reaction cup being in the test position reaches the test duration corresponding to the first item, the reaction cup is controlled to enter the cup discarding position.

[0060] It can be seen from the above technical scheme that in a control method for sample detection in a coagulation analyzer and a coagulation analyzer provided by the present application, by configuring the sample rack in the coagulation analyzer into multiple wells and configuring the number of preheating positions in the preheating tray and the number of test positions in the test tray to be greater than the number of wells, when the coagulation analyzer performs the detection of the first item, the multiple wells can be sampled and detected in batches, that is, the reaction cup corresponding to each well is loaded with samples, preheated, added with reagents, and discarded in turn. Since the reagents added to the reaction cups are all the first reagents, after adding the first reagent to a reaction cup, there is no need to clean the first reagent needle, and the first reagent can be continued to be used to add the first reagent to the next reaction cup, thereby reducing the time consumption generated by cleaning the first reagent needle, thereby improving the detection efficiency of the coagulation analyzer for the first sample on the first item. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0062] Figure 1 A flow chart of a control method for sample detection in a coagulation analyzer provided in Example 1 of the present application;

[0063] Figure 2 Another flow chart of a control method for sample detection in a coagulation analyzer provided in Embodiment 1 of the present application;

[0064] Figure 3 A partial flow chart of a control method for sample detection in a coagulation analyzer provided in Example 1 of the present application;

[0065] Figure 4 and Figure 5 They are respectively another flow chart of a control method for sample detection in a coagulation analyzer provided in Embodiment 1 of the present application;

[0066] Figure 6 A schematic diagram of the structure of a control device for sample detection in a coagulation analyzer provided in Example 2 of the present application;

[0067] Figure 7 A schematic diagram of the structure of a coagulation analyzer provided in Example 3 of the present application;

[0068] Figure 8 as well as Fig. 9 They are respectively some example diagrams of the fully automatic coagulation analyzer in this application;

[0069] Fig.10 This is a flow chart for scheduling and controlling the fully automatic coagulation analyzer for this application. DETAILED DESCRIPTION

[0070] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0071] refer to Figure 1 As shown, it is a flow chart of the control method for sample detection in a coagulation analyzer provided in the first embodiment of the present application, and the method is applicable to the coagulation analyzer. The coagulation analyzer at least includes multiple sample racks, sample adding needles, a first reagent needle, a second reagent needle, multiple reaction cups, a pre-heating tray containing multiple pre-heating positions, a test tray containing multiple test positions, a cup position and a controller, wherein each sample rack contains multiple holes, each hole is used to place a tube of sample, and the number of reaction cups is greater than or equal to the number of holes in the sample rack, the number of pre-heating positions is greater than the number of holes in the sample rack, and the number of test positions is also greater than the number of holes in the sample rack, and the controller is a control chip running the circuit board software of the coagulation analyzer. For example, there are 10 holes in a sample rack, 10 reaction cups, 32 pre-heating positions in the pre-heating tray, and 20 test positions in the temperature measuring tray. The controller schedules and controls the various components in the coagulation analyzer to realize the detection of samples. The technical solution in this embodiment is mainly used to improve the efficiency of sample detection by the coagulation analyzer.

[0072] Specifically, the method in this embodiment may include the following steps:

[0073] Step 101: Control the first sample rack in the coagulation analyzer to move from the sample position to the sample suction position corresponding to the sample adding needle in the coagulation analyzer.

[0074] The wells in the first sample rack are respectively placed with first samples, where the first samples can be blood samples to be tested, and the first samples placed in each well are different. The first samples can be added to the first sample rack manually or by an automatic adding tool by a staff member, and the first samples in the first sample rack are used to test a first item, such as a PT item. For example, a staff member adds blood samples of 10 people to 10 wells in the first sample rack, and the coagulation analyzer performs PT tests on the blood samples of these 10 people.

[0075] It should be noted that there are other sample racks in the coagulation analyzer, such as the second sample rack, the third sample rack, etc. Taking the second sample rack as an example, the second sample rack is arranged in the next sample rack position of the first sample rack, and the holes in the second sample rack can be used to place the first sample or other samples such as the second sample, and the second sample is the same as or different from the first sample. In the case where the second sample is different from the first sample, the second sample in the second sample rack can be used to continue to detect the first item or to detect the second item. In the case where the second sample is the same as the first sample, the second sample in the second sample rack is used to detect the second item. For example, the staff adds the blood samples of 10 people to the 10 holes in the first sample rack, and the staff also adds the blood samples of these 10 people to the 10 holes in the second sample rack, and the coagulation analyzer performs PT and APTT tests on the blood samples of these 10 people.

[0076] It should be noted that the sample position refers to the initial position of the sample rack after the sample is added, and the sample suction position corresponding to the sample adding needle here refers to the position where the sample adding needle can suck the sample in the hole position. For the purpose of distinction, the sample suction position corresponding to the sample adding needle here can be recorded as the first sample suction position. In this embodiment, the first sample rack is controlled to move from the sample position to the first sample suction position.

[0077] Based on this, after the first sample rack is controlled to move from the sample position to the first sample aspiration position, the sample adding needle moved to the first sample aspiration position can absorb the first sample from the empty position of the first sample rack. Therefore, in this embodiment, the following processes are sequentially performed for each well position in the first sample rack:

[0078] Step 102: Control the sample adding needle to absorb the first sample from the hole.

[0079] In this embodiment, the sample adding needle is controlled to move to the first sample aspirating position in advance, so that the sample adding needle can aspirate the first sample in the hole of the first sample rack into the inside of the sample adding needle.

[0080] Step 103: Control the sample adding needle to add the first sample into the reaction cup at the sample discharging position.

[0081] In this embodiment, after the sample adding needle is controlled to absorb the first sample from the hole, the sample adding needle is first controlled to move from the sample aspiration position to the sample discharge position, and the reaction cup is pre-controlled to move to the sample discharge position. Based on this, the sample adding needle is controlled to discharge the first sample inside into the reaction cup.

[0082] It should be noted that the number of available reaction cups in the coagulation analyzer is greater than or equal to the number of wells in the first sample rack. In a preferred embodiment, the number of reaction cups is consistent with the number of wells to avoid wasting time due to insufficient number of reaction cups and the need to wait for reaction cups.

[0083] It should be noted that after the sample adding needle adds the first sample to the reaction cup, the sample adding needle can prepare to absorb the first sample of the next well and add it to the corresponding reaction cup until the first samples in all wells in the first sample rack are added to the corresponding reaction cups.

[0084] Step 104: Control the reaction cup to enter a pre-heating position in the pre-heating tray, so that the sample in the reaction cup enters a pre-heating state.

[0085] In this embodiment, the number of pre-heating positions in the pre-heating plate is greater than the number of holes in the sample rack, so as to avoid the situation where the time is wasted due to the need to wait for the pre-heating positions due to the insufficient number of pre-heating positions.

[0086] It should be noted that, in this embodiment, the timing may be started when the reaction cup enters the pre-heating position to record the duration of the first sample in the reaction cup being in the pre-heating state.

[0087] Step 105: Determine whether the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the first item. If not, continue to execute step 105 until the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the first item, and then execute step 106.

[0088] The pre-warming time of the samples may vary depending on the items being tested. For example, the pre-warming time required for the samples in the PT project is different from that required for the samples in the APTT project.

[0089] Step 106: Control the reaction cup to enter a test position in the test tray.

[0090] The number of test positions in the test tray is greater than the number of holes in the sample rack, so as to avoid the situation where time is wasted due to the need to wait for the test positions due to insufficient number of test positions.

[0091] It should be pointed out that the pre-heating plate reserves a pre-heating position for the first sample when the sample needle starts to absorb the first sample. The reserved pre-heating position waits for the reaction cup to enter, and the pre-heating position will not be released until the reaction cup enters the test position.

[0092] Step 107: Control the first reagent needle to add the first reagent corresponding to the first item into the reaction cup.

[0093] Among them, in this embodiment, the first reagent needle is pre-moved to the sample suction position corresponding to the reagent disk, that is, the second sample suction position, and then the first reagent needle is controlled to suck the first reagent in the required reagent bottle corresponding to the reagent disk into the inside of the first reagent needle, and then the first reagent needle is controlled to move to the sample discharge position. Thus, the first reagent needle is controlled to add the first reagent to the reaction cup at the sample discharge position, so that the pre-heated first sample in the reaction cup reacts with the first reagent.

[0094] It should be noted that, in this embodiment, after the first reagent is added to the reaction cup, it reacts with the pre-heated first sample in the reaction cup. Based on this, this embodiment can obtain the detection result of the first sample on the first item according to the reaction state between the first sample and the first reagent.

[0095] It should be noted that after the first reagent needle adds the first reagent to the reaction cup, the first reagent needle can be prepared to add the first reagent to the next reaction cup until the first reagent is added to the corresponding reaction cups in all wells in the first sample rack. In this process, since the reagents added by the first reagent needle are all the first reagents corresponding to the first project, the first reagent needle does not need to be cleaned and can be used for the next addition of the first reagent.

[0096] Step 108: Determine whether the duration of time the first reagent is added to the reaction cup reaches the test duration corresponding to the first item. When the duration of time the first reagent is added to the reaction cup reaches the test duration corresponding to the first item, execute step 109; otherwise, return to step 108 until the duration of time the first reagent is added to the reaction cup reaches the test duration corresponding to the first item.

[0097] The sample detection items are different, and the reaction time between the corresponding sample and the reagent is different, that is, the test time is different. After the first reagent is added to the reaction cup, the timing starts, and until the recorded duration reaches the corresponding test time of the first item, step 109 can be executed.

[0098] Step 109: Control the reaction cup to enter the cup discarding position.

[0099] Among them, the lost cup position is used to store the reaction cups that have been used and need to be recycled.

[0100] It should be noted that the test position in the test tray is occupied when the reaction cup enters, and the occupied test position will not be released until the reaction cup enters the cup discarding position.

[0101] It should be noted that in this embodiment, the first sample placed in each well in the first sample rack is controlled according to the process from step 102 to step 109, thereby realizing the detection of the first item for the first sample in each well in the form of a batch assembly line.

[0102] It can be seen from the above scheme that in a control method for sample detection in a coagulation analyzer provided in Example 1 of the present application, by configuring the sample rack in the coagulation analyzer into multiple wells and configuring the number of preheating positions in the preheating tray and the number of test positions in the test tray to be greater than the number of wells, when the coagulation analyzer performs the detection of the first item, the multiple wells can be sampled and detected in batches, that is, the reaction cup corresponding to each well is loaded with samples, preheated, added with reagents, and discarded, etc. in turn. Since the reagent added to the reaction cup is the first reagent, after adding the first reagent to a reaction cup, there is no need to clean the first reagent needle and the first reagent can be continued to be used to add the first reagent to the next reaction cup, thereby reducing the time consumption generated by cleaning the first reagent needle, thereby improving the detection efficiency of the coagulation analyzer for the first sample on the first item.

[0103] Based on the above scheme, after step 107, the first reagent is added to the reaction cup. At this time, the method in this embodiment may also include the following steps: Figure 2 As shown in:

[0104] Step 110: Irradiate the reaction cup with target light.

[0105] The target light is a light whose illumination intensity is within a preset intensity range.

[0106] Step 111: collecting the light intensity change value of the reaction cup under the target light until it is determined in step 108 that the duration of adding the first reagent to the reaction cup reaches the test duration corresponding to the first item.

[0107] Specifically, in this embodiment, by collecting images of the reaction cup under the target light and analyzing the collected images, the light intensity change value of the first sample in the reaction cup under the target light under the action of the first reagent can be obtained.

[0108] Step 112: Obtain a detection result of the first sample on the first item according to the light intensity change value.

[0109] Among them, in this embodiment, the light intensity change value can be analyzed according to the preset detection rules, for example, the size judgment of the light intensity change value, the changing trend of the light intensity change value, etc., thereby, based on these analysis results, the detection result of the first sample on the first item is obtained, such as the detection result on the PT item.

[0110] In one implementation, step 107 sequentially controls the first reagent needle to add the first reagent corresponding to the first project to the reaction cup corresponding to each well of the first sample rack. Based on this, before controlling the first reagent needle to add the first reagent to the reaction cup corresponding to the first well of the first sample rack, the method in this embodiment may further include the following steps: Figure 3 As shown in:

[0111] Step 113: Determine whether the second sample in the second sample rack in the coagulation analyzer is used to detect the second item. The second sample rack here is a sample rack that is moved to the sample suction position before the first sample rack, and the second item is different from the first item. If the second sample in the second sample rack is used to detect the second item, then execute step 114.

[0112] Step 114: Clean the first reagent needle.

[0113] For example, if the first reagent needle has been used to absorb the reagent corresponding to the second item (APTT item) before absorbing the reagent corresponding to the first item (PT item), then the first reagent needle should be cleaned before the first reagent needle absorbs the reagent corresponding to the first item to avoid the situation where the reagent corresponding to the second item remains in the first reagent needle and interferes with the reaction between the first sample and the first reagent, resulting in errors in the detection of the first item.

[0114] In a specific implementation, the coagulation analyzer corresponds to a time period for detection and control, and each component in the coagulation analyzer performs an action in each time period. In order to speed up the detection rate of the coagulation analyzer for the sample, the time period can be configured to 8.5 seconds or 9 seconds in this embodiment. The following takes the time period of 9 seconds as an example to illustrate the technical solution in this embodiment. It should be noted that when the time period is 8.5 seconds, the following time points are scaled in the same proportion as 9 and 8.5.

[0115] Based on this, in step 101, when controlling the first sample rack in the coagulation analyzer to move from the sample position to the preset sample suction position, specifically:

[0116] At a first time point in the first time period, the first sample rack in the coagulation analyzer is controlled to start moving from the sample position to the preset sample suction position, so that the first sample rack reaches the sample suction position at a second time point in the second time period. The second time period here is the time period after the first time period.

[0117] It should be noted that the first time period, the second time period, etc. in this embodiment are aliases for specific time periods, which are used to distinguish different time periods for detection and control of the coagulation analyzer.

[0118] For example, in this embodiment, the rack is advanced at the 7th second in the first time period, that is, the first sample rack is moved from the sample position to the sample aspiration position of the sample loading needle, and the rack advancement is completed at the 1.5th second of the next time period, i.e., the second time period. That is to say, at the 1.5th second of the second time period, the first sample rack is at the sample aspiration position corresponding to the sample loading needle.

[0119] In addition, after the sample needle is controlled to absorb the first sample from the last hole in the first sample rack, that is, after the first samples in each hole in the first sample rack are tested, in this embodiment, the first sample rack can be controlled to move from the sample aspiration position to the sample position at the third time point in the third time period, so that the first sample rack reaches the sample position at the fourth time point in the third time period. In this way, other sample racks can be moved to the sample aspiration position corresponding to the sample needle, so that the samples in the sample rack moved to the sample aspiration position can continue to be tested for corresponding items.

[0120] The fourth time point here is smaller than the first time point.

[0121] For example, in this embodiment, the unloading is performed at the 4.5th second in the third time period, that is, the first sample rack is moved from the sample suction position to the sample position, and the unloading takes 2 seconds. The unloading is completed at the 6.5th second in the current time period, that is, the third time period, that is, the first sample rack is at the sample position at the 6.5th second in the third time period. Here, the unloading (retraction) is completed at the 6.5th second before the loading is performed at the 7th second, thereby avoiding the conflict between loading and unloading.

[0122] Based on the above implementation method, in this embodiment, when controlling the sample loading needle to absorb the first sample from the hole position and add the first sample to the reaction cup at the sample arrangement position, at the fifth time point in the fourth time period, the sample loading needle of the coagulation analyzer can be controlled to start absorbing the first sample from the hole position and add the first sample to the reaction cup at the sample arrangement position, so that the first sample is added at the fifth time point in the fifth time period.

[0123] The fifth time period is a time period after the fourth time period, and after a fifth time point in the fifth time period, the sample adding needle can be used to draw the corresponding first sample from other wells.

[0124] For example, in this embodiment, the sample adding needle starts adding samples at the 0th second of the fourth time period, and after 1 to m time periods, the sample adding is completed at the 0th second of the fifth time period, where m is a positive integer greater than or equal to 1.

[0125] Based on the above implementation method, in this embodiment, at the fifth time point in the fourth time period, a corresponding pre-heating position can be configured for the hole position in the pre-heating tray, so that the pre-heating position starts waiting for the reaction cup corresponding to the hole position to enter from the fifth time point in the fourth time period, that is, starting from the time when the sample is added to the reaction cup, one pre-heating position in the pre-heating tray is occupied, waiting for the reaction cup to which the first sample is added to enter.

[0126] After the reaction cup corresponding to the well position enters the test position from the pre-heating position, the pre-heating position waits to be configured as the pre-heating position corresponding to other well positions. In other words, after the reaction cup in the pre-heating position leaves, the pre-heating position is no longer occupied and can be used to place other reaction cups.

[0127] For example, at the 0th second of the fourth time period, the sample adding needle starts adding samples, and a pre-heating position in the pre-heating tray is in an occupied state, waiting for a reaction cup to be added with the first sample, until the reaction cup leaves the pre-heating position. The pre-heating position that the reaction cup has left can be reserved for other reaction cups to occupy.

[0128] In one implementation, in this embodiment, when the first reagent needle is cleaned, the first reagent needle can be cleaned at the sixth time point of the sixth time period, so that the first reagent needle is completely cleaned at the sixth time point of the seventh time period, and the cleaned first reagent needle can be used to add the first reagent to the reaction cup. The seventh time period here is the time period after the sixth time period. Based on this, at the sixth time point of the seventh time period, the first reagent needle can start to add the first reagent to the reaction cup.

[0129] For example, in this embodiment, the first reagent needle starts to be cleaned at the 6th second of the 6th time period, and the cleaning is completed at the 6th second of the 7th time period. The cleaning duration is 1 to n time periods, and n is a positive integer greater than 1 or equal to 1. Afterwards, starting from the 6th second of the 7th time period, the first reagent needle can start to add the first reagent to the reaction cup.

[0130] In one implementation, there is a situation where a plurality of reagents need to be added to the sample for a test item. Based on this, when the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the first item, before the reaction cup is controlled to enter a test position in the test disk of the coagulation analyzer in step 106, the present embodiment may further include the following steps: Figure 4 As shown in:

[0131] Step 115: At the seventh time point of the eighth time period, control the second reagent needle to add the second reagent corresponding to the first item into the reaction cup, so that the second reagent in the reaction cup at the pre-heating position is pre-heated.

[0132] For example, at the 2nd second of the eighth time period, the second reagent needle is controlled to add the second reagent into the reaction cup.

[0133] Step 116: Determine whether the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the second reagent. When the duration of the reaction cup being in the preheating state, that is, the duration of the second reagent being preheated, reaches the preheating time corresponding to the second reagent, execute step 106: control the reaction cup to enter a test position in the test tray of the coagulation analyzer.

[0134] Specifically, when controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer in step 106, the reaction cup can be moved from the preheating position to the test position using a transfer gripper at the eighth time point in the ninth time period, so that the reaction cup reaches the test position at the ninth time point in the ninth time period.

[0135] For example, after controlling the second reagent needle to add the second reagent into the reaction cup at the 2nd second of the eighth time cycle, the second reagent in the reaction cup is in a preheating state until the duration of the preheating of the second reagent reaches the corresponding preheating time. At the 4th second of the ninth time cycle, the reaction cup is moved from the preheating position to the testing position by the transfer gripper until the reaction cup reaches the testing position at the 6th second of the ninth time cycle.

[0136] Based on the above implementation, in step 115, before controlling the second reagent needle to add the second reagent to the reaction cup corresponding to the first hole position in the first sample rack, in this embodiment, it can also be determined whether the second sample in the second sample rack in the coagulation analyzer is used to detect the second item. The second sample rack here is the sample rack that is moved to the sample suction position before the first sample rack, and the second item and the first item, if the second sample in the second sample rack is used to detect the second item, it indicates that other reagents different from the second reagent may remain in the second reagent needle. At this time, the second reagent needle of the coagulation analyzer can be cleaned at the seventh time point of the tenth time period, so that the second reagent needle is cleaned at the seventh time point of the eighth time period, and the eighth time period here is the time period after the tenth time period. In this way, it is avoided that the reagent corresponding to the second item is left in the second reagent needle, interfering with the reaction between the first sample and the second reagent, resulting in errors in the detection of the first item.

[0137] For example, if the second reagent needle has been used to absorb the reagent corresponding to the second item before absorbing the reagent corresponding to the first item, then before the second reagent needle absorbs the reagent corresponding to the first item, the second reagent needle is first cleaned at the 2nd second in the tenth time cycle, and the second reagent needle is cleaned at the 2nd second in the eighth time cycle. Thereafter, at the 2nd second in the eighth time cycle, the second reagent needle is controlled to add the second reagent to the reaction cup. At this time, the reaction cup is in the preheating position, and the second reagent in the reaction cup is in a preheating state. Until the duration of the preheating of the second reagent reaches the corresponding preheating time, at the 4th second in the ninth time cycle, the reaction cup is moved from the preheating position to the test position by the transfer gripper, and the reaction cup reaches the test position at the 6th second in the ninth time cycle.

[0138] In one implementation, in some test items, the sample and the reagent need to be mixed. Therefore, in step 107, after the first reagent needle of the coagulation analyzer is controlled to add the first reagent corresponding to the first item into the reaction cup, the method in this embodiment may further include the following steps: Figure 5 As shown in:

[0139] Step 117: At the tenth time point in the eleventh time period, the reaction cup begins to be moved from the test position to the test mixing position by using the transfer gripper, so that the reaction cup reaches the test mixing position at the eleventh time point in the eleventh time period.

[0140] For example, at the 6th second of the eleventh time period, the reaction cup starts to move from the test position to the test mixing position by using the transfer gripper, and reaches the test mixing position at the 1.5th second of the eleventh period.

[0141] Among them, at the test mixing position, the reaction cup is subjected to a mixing operation, and the sample and reagent in the reaction cup are mixed.

[0142] Step 118: determine whether the duration of the reaction cup being in the test mixing position reaches the mixing time corresponding to the first reagent. If the duration of the reaction cup being in the test mixing position reaches the mixing time corresponding to the first reagent, execute step 119.

[0143] Among them, the mixing time may be different depending on the reagent.

[0144] Step 119: at the eleventh time point of the twelfth time period, the reaction cup is moved from the test mixing position to the test position by using the transfer gripper, so that the reaction cup reaches the test position at the twelfth time point of the twelfth time period.

[0145] For example, at 2.5 seconds of the twelfth time period, the reaction cup is moved from the test mixing position to the test position using the transfer gripper, and the moving time is 1 second. At 3.5 seconds of the twelfth time period, the reaction cup reaches the test position.

[0146] Based on this, when the duration of the reaction cup in the test position reaches the test time corresponding to the first item, at the thirteenth time point in the thirteenth time period in step 109, the transfer gripper is used to move the reaction cup from the test position to the cup discarding position, so that the reaction cup reaches the cup discarding position at the fourteenth time point in the fourteenth time period.

[0147] For example, at the 8th second of the 13th time period, the reaction cup is moved from the test position to the cup discarding position by means of a transfer, and the moving time is 2 seconds, so that the reaction cup reaches the cup discarding position at the 1st second of the 14th time period.

[0148] refer to Figure 6 , is a structural schematic diagram of a control device for sample detection in a coagulation analyzer provided in Example 2 of the present application, and the device is configured on the coagulation analyzer, such as the circuit board software of the coagulation analyzer. The coagulation analyzer at least includes multiple sample racks, sample adding needles, a first reagent needle, a second reagent needle, multiple reaction cups, a pre-heating tray containing multiple pre-heating positions, a test tray containing multiple test positions, a cup dropping position and a controller, wherein each sample rack contains multiple holes, each hole is used to place a tube of sample, and the number of reaction cups is greater than or equal to the number of holes in the sample rack, the number of pre-heating positions is greater than the number of holes in the sample rack, and the number of test positions is also greater than the number of holes in the sample rack, and the controller is a control chip running the circuit board software of the coagulation analyzer. For example, there are 10 holes in a sample rack, 10 reaction cups, 32 pre-heating positions in the pre-heating tray, and 20 test positions in the temperature measuring tray. The controller schedules and controls the various components in the coagulation analyzer to realize the detection of samples. The technical solution in this embodiment is mainly used to improve the efficiency of sample detection by the coagulation analyzer.

[0149] Specifically, the method in this embodiment may include the following units:

[0150] The rack feed control unit 601 is used to control the first sample rack in the coagulation analyzer to move from the sample position to the sample suction position corresponding to the sample injection needle, wherein the first sample is placed in the hole of the first sample rack, and the first sample is used to detect the first item;

[0151] For each well in the first sample rack, the following units are triggered in sequence:

[0152] A sample adding control unit 602, used for controlling the sample adding needle in the coagulation analyzer to draw the first sample from the well position and add the first sample into the reaction cup at the sample arrangement position, wherein the number of the reaction cups is consistent with the number of the well positions;

[0153] A pre-temperature control unit 603 is used to control the reaction cup to enter a pre-temperature position in the pre-temperature tray of the coagulation analyzer, so that the sample in the reaction cup enters a pre-temperature state; the number of pre-temperature positions in the pre-temperature tray is greater than the number of holes in the sample rack;

[0154] The test control unit 604 is used to control the reaction cup to enter a test position in the test tray of the coagulation analyzer when the duration of the reaction cup in the preheating state reaches the preheating time corresponding to the first item; the number of test positions in the test tray is greater than the number of holes in the sample rack;

[0155] A reagent adding unit 605, used for controlling the first reagent needle of the coagulation analyzer to add the first reagent corresponding to the first item into the reaction cup;

[0156] The cup discarding control unit 606 is used to control the reaction cup to enter the cup discarding position when the duration of adding the first reagent to the reaction cup reaches the test duration corresponding to the first item.

[0157] It can be seen from the above technical scheme that in a control device for sample detection in a coagulation analyzer provided in Example 2 of the present application, by configuring the sample rack in the coagulation analyzer into multiple wells and configuring the number of pre-heating positions in the pre-heating tray and the number of test positions in the test tray to be greater than the number of wells, when the coagulation analyzer performs the detection of the first item, the multiple wells can be sampled and detected in batches, that is, the reaction cup corresponding to each well is loaded with samples, pre-heated, added with reagents, and discarded in turn. Since the reagent added to the reaction cup is the first reagent, after adding the first reagent to a reaction cup, there is no need to clean the first reagent needle, and the first reagent can be continued to be used to add the first reagent to the next reaction cup, thereby reducing the time consumption generated by cleaning the first reagent needle, thereby improving the detection efficiency of the coagulation analyzer for the first sample on the first item.

[0158] It should be noted that the specific implementation of each unit in this embodiment can refer to the corresponding content in the previous text and will not be described in detail here.

[0159] refer to Figure 7 , is a schematic diagram of the structure of a coagulation analyzer provided in Example 3 of the present application, and the coagulation analyzer may include the following structure:

[0160] There are multiple sample racks 701 , each of which includes multiple wells 702 , and each well 702 is used to place a tube of sample. In an initial state, the sample racks 701 are all located on the sample positions 703 .

[0161] Sample injection needle 704;

[0162] First reagent needle 705;

[0163] A plurality of reaction cups 706 , wherein the number of the reaction cups 706 is greater than the number of the wells 702 in the sample rack 701 ;

[0164] A pre-heating plate 708 comprising a plurality of pre-heating positions 707 , wherein the number of the pre-heating positions 707 is greater than the number of the wells 702 in the sample rack 701 ;

[0165] A test tray 710 comprising a plurality of test positions 709 , wherein the number of the test positions 709 is greater than the number of the wells 702 in the sample rack 701 ;

[0166] Lost cup position 711;

[0167] The controller 712 is used to control the first sample rack 713 to move from the sample position 703 to a preset sample suction position, wherein a first sample is placed in the hole 702 of the first sample rack 713, and the first sample is used to detect a first item;

[0168] The controller 712 sequentially executes the following processes for each well 703 in the first sample rack 713:

[0169] Control the sample adding needle 704 to absorb the first sample from the well 702 and add the first sample to the reaction cup 706 at the sample arrangement position, and the number of the reaction cup 706 is consistent with the number of the well 702;

[0170] Controlling the reaction cup 706 to enter a pre-heating position 707 in the pre-heating tray 708 so that the sample in the reaction cup 706 enters a pre-heating state;

[0171] When the duration of the reaction cup 706 being in the preheating state reaches the preheating duration corresponding to the first item, controlling the reaction cup 706 to enter a test position 709 in the test tray 710;

[0172] Controlling the first reagent needle 705 to add the first reagent corresponding to the first project into the reaction cup 706;

[0173] When the duration of the reaction cup 706 being in the test position 709 reaches the test duration corresponding to the first item, the reaction cup 706 is controlled to enter the cup discarding position 711 .

[0174] It can be seen from the above technical scheme that in a coagulation analyzer provided in Example 3 of the present application, by configuring the sample rack in the coagulation analyzer into multiple wells and configuring the number of pre-heating positions in the pre-heating tray and the number of test positions in the test tray to be greater than the number of wells, when the coagulation analyzer performs the detection of the first item, the multiple wells can be sampled and tested in batches, that is, the reaction cup corresponding to each well is loaded with samples, pre-heated, added with reagents, and discarded in turn. Since the reagent added to the reaction cup is the first reagent, after adding the first reagent to a reaction cup, there is no need to clean the first reagent needle, and the first reagent can be continued to be used to add the first reagent to the next reaction cup, thereby reducing the time consumption generated by cleaning the first reagent needle, thereby improving the detection efficiency of the coagulation analyzer for the first sample on the first item.

[0175] Taking the fully automatic coagulation analyzer as an example, the coagulation analyzer adopts the principle of optical method. For the detection items based on coagulation method, chromogenic substrate method and immunoturbidimetry method, it collects sample data through the principle of photoelectric sensing and processes the data to obtain the detection results of the measurement items. The coagulation analyzer of the present application is composed of a cup selection system (reaction cup, reaction cup replenishment position), a sample addition system (including a sample addition needle and a diluent placement position), a test system (including a test channel formed by a test position), a cleaning system (cleaning tank), a mixing system (test mixing position), a code reading system (such as a controller, a circuit board), etc. Figure 8 and Fig. 9 The sample loading system can realize the loading of samples and reagents, the test system can realize the testing and data collection of samples, the cleaning system can realize the flushing of the sample loading needle, the mixing system can realize the mixing of samples and reagents in the reaction cup, the code reading system can realize the reading and input of reagent and cleaning liquid information, the operating software system and the auxiliary system can realize the human-computer interactive operation interface and include the functions of specimens, reagents, calibration, quality control, reports and system settings, and realize the analysis of coagulation detection items and the output of test results.

[0176] Based on the technical solution in the previous article, this application proposes a solution for scheduling tasks of fully automatic coagulation analyzer detection projects, such as Fig.10 As shown in , it mainly consists of the following scheduling steps:

[0177] (1) Sample rack scheduling: Arrange the time points for entering and exiting the rack.

[0178] (2) Sample needle scheduling: arrange the time points for sample addition and cleaning of the sample needle.

[0179] (3) Pre-temperature channel scheduling: schedule the time when each pre-temperature channel is occupied.

[0180] (4) Test channel scheduling: schedule the time when each test channel is occupied.

[0181] (5) Reagent needle scheduling: Arrange the time points for adding samples and cleaning each reagent needle.

[0182] (6) Transfer gripper scheduling: Arrange the time point for executing each action of the transfer gripper at the test position.

[0183] (7) Arrangement of task execution process.

[0184] The time point represents the number of seconds when the action is executed in one cycle (starting from 0 seconds). One cycle is based on 9 seconds as the scheduling basis of the software, and the ratio is reduced from 9 seconds to 8.5 seconds. After the time point is scaled by this ratio, the fully automatic coagulation analyzer performs detection items according to each time point.

[0185] To achieve the above functions, this application proposes the following solutions:

[0186] (1) Sample rack scheduling: Arrange the time points for entering and exiting the rack.

[0187] a. Time point for entering the shelf: Entering the shelf at the 7th second, and the execution time is 3.5 seconds.

[0188] b. Time of release: The product is released at 4.5 seconds, and the execution time is 2 seconds.

[0189] c. During the rack cutting action, the sample rack in the guide rail will be unloaded first, starting at 4.5 seconds and ending at 6.5 seconds. Then, the sample rack that needs to be loaded with samples will be loaded at 7 seconds to ensure that there is no conflict between loading and unloading.

[0190] (1) Sample needle scheduling: arrange the time points for sample injection and cleaning of the sample needle.

[0191] a. The time points for adding samples and cleaning the sample needle are both performed at 0 seconds.

[0192] b. Each execution time is N (preset value) cycles.

[0193] c. Only one task can use the sample needle at a time to ensure that the sample needles do not conflict.

[0194] (2) Pre-temperature channel scheduling: schedule the time when each pre-temperature channel is occupied.

[0195] a. There are 32 pre-temperature channels in total.

[0196] b. The start time of occupancy is when the sample needle starts to add sample to the preheating channel.

[0197] c. The end time of occupancy is when the pre-heating plate is transferred to the test plate.

[0198] d. The middle part includes: adding samples with sample needle, pre-warming samples, adding samples with single reagent needle, and pre-warming reagents after adding samples with single reagent needle.

[0199] e. A pre-heating channel can only be occupied by one task at a time to ensure that the pre-heating channels do not conflict.

[0200] (3) Test channel scheduling: schedule the time when each test channel is occupied.

[0201] a. There are 20 test channels in total.

[0202] b. The start time of occupancy is when the pre-heating plate is transferred to the test plate.

[0203] c. The end time of occupation is when the cup is thrown away.

[0204] d. The middle step includes: reagent mixing, double reagent needle addition, reagent pre-warming after double reagent needle addition, and cup discarding.

[0205] e. A test channel can only be occupied by one task at a time to ensure that the test channels do not conflict.

[0206] (4) Reagent needle scheduling: Arrange the time points for adding samples and cleaning each reagent needle.

[0207] a. There are two types of reagent needles: single reagent needle (second reagent needle) and double reagent needle (first reagent needle).

[0208] b. The time points for adding samples and cleaning the single reagent needle are both executed at the 2nd second, and the length of each execution is N cycles.

[0209] c. The time points for adding samples and cleaning the dual reagent needles are both performed at the 6th second, and the length of each execution is N cycles.

[0210] d. Reagent needles do not affect each other, and multiple reagent needles can be executed at the same time.

[0211] e. However, the same reagent needle can only perform one task at a time to ensure that the reagent needles do not conflict.

[0212] (5) Transfer gripper scheduling: Arrange the time point for executing each action of the test position transfer gripper.

[0213] a. The transfer gripper's actions include transferring from the pre-heating plate to the test plate, transferring from the test plate to the test mixing position, transferring from the test mixing position to the test plate, and transferring from the test plate to the cup dropping position.

[0214] b. The time point when the pre-heating disk is transferred to the test disk: it is executed at the 4th second and the execution time is 2 seconds.

[0215] c. The time point when the test plate is transferred to the test mixing position: executed at the 6th second, and the execution time is 1.5 seconds.

[0216] d. The time point when the test mixing position is transferred to the test disk is executed at 2.5 seconds and the execution time is 1 second.

[0217] e. The time point when the test disk is transferred to the cup-dropping position: executed at the 8th second, and the execution time is 2 seconds.

[0218] f. Only one transfer gripper action can be executed at a time to ensure that the transfer grippers do not conflict.

[0219] (6) Arrange the task flow. The following process is required to execute a test for a task:

[0220] a. The sample rack corresponding to the task is loaded into the rack.

[0221] b. If cleaning is required before the sample needle is added, it will be performed during the cycle when the sample needle is put into the rack.

[0222] c. After the rack is loaded, the sample is loaded with the sample needle. At this time, a pre-heating channel is occupied.

[0223] d. After the sample is added with the sample needle, it enters the pre-warming plate to pre-warm the sample.

[0224] e. If all the tasks on the sample rack have been completed, execute the sample rack unloading.

[0225] f. If the sample needle needs to be cleaned after loading, perform the cleanup after the sample needle is loaded.

[0226] g. If a single reagent needle is required for sample addition:

[0227] If a single reagent needle pre-cleaning is required, perform the single reagent needle pre-cleaning cycle before the sample pre-warming is completed.

[0228] After the sample is pre-heated, perform single reagent needle injection, and after injection, perform reagent pre-heating.

[0229] If single reagent needle post-cleaning is required, perform single reagent needle post-cleaning after single reagent needle addition is completed.

[0230] Before the reagent preheating is completed, the task is transferred from the preheating tray to the test tray in advance according to the number of advance transfer cycles. At this time, the preheating channel occupancy ends and a test channel begins to be occupied.

[0231] h. If single reagent needle addition is not required, before the sample preheating is completed, the task is transferred from the preheating plate to the test plate in advance according to the number of advance transfer cycles. At this time, the preheating channel occupancy ends and a test channel begins to be occupied.

[0232] i. If a single reagent injection is required for mixing:

[0233] After the task is transferred to the test disk, the test disk is transferred to the test mixing position.

[0234] After transferring to the test mix position, perform the mix.

[0235] After the mixing is completed, the test mixing position is transferred to the test plate.

[0236] j. If double reagent needle addition is required:

[0237] If dual reagent needle pre-cleaning is required, perform dual reagent needle pre-cleaning one cycle before dual reagent needle injection.

[0238] Perform double reagent needle loading and pre-warm the reagents after loading is completed.

[0239] If double reagent needle post-cleaning is required, perform double reagent needle post-cleaning after double reagent needle addition is completed.

[0240] If dual reagent needle mixing is required:

[0241] After the reagents are pre-warmed, transfer the test plate to the test mixing position.

[0242] After transferring to the test mix position, perform the mix.

[0243] After the mixing is completed, the test mixing position is transferred to the test plate.

[0244] k. Enter the testing cycle.

[0245] l. If the test can be ended early, after the test results come out, the test disk is transferred to the cup-losing position; otherwise, after the maximum test cycle of the project is reached, the test disk is transferred to the cup-losing position.

[0246] m. The cup-throwing operation is completed and the test channel occupation ends.

[0247] Taking a D-Dimer detection project as an example, the specific detection scheduling process is as follows:

[0248] At 7.0 seconds in cycle 0, the sample rack entry begins;

[0249] At 1.5 seconds of the first cycle, the sample rack was loaded into the rack;

[0250] At 0.0 seconds in the second cycle, the sample injection needle starts to inject the sample, the preheating position 1 in the preheating channel begins to be occupied, and the reaction cup reaches the preheating plate;

[0251] At 0.0 seconds in the third cycle, the sample injection is completed and the sample preheating begins. It takes 4 preheating cycles.

[0252] At 4.5 seconds of the third cycle, the sample loading by the sample loading needle is completed, and there is no other sample loading task required, so the sample rack is withdrawn;

[0253] At 6.5 seconds into the third cycle, the sample rack was unloaded;

[0254] At 2.0 seconds into the sixth cycle, the reagent needle at the pre-warming position was pre-cleaned;

[0255] At 0.0 seconds in the 7th cycle, sample pre-warming is completed;

[0256] At 2.0 seconds into the seventh cycle, the single reagent needle was cleaned before completion, and the single reagent needle added DD R1 reagent into the reaction cup;

[0257] At 2.0 seconds into the 8th cycle, the single reagent needle added DD R1 reagent into the reaction cup, and the single reagent needle pre-warming cycle 19 began;

[0258] At 4.0 seconds in the 25th cycle, transfer from the pre-warming plate to the test plate;

[0259] At 6.0 seconds into the 25th cycle, the transfer from the pre-warming plate to the test plate is completed, and the reaction cup reaches the test plate;

[0260] At 6.0 seconds into the 26th cycle, the dual reagent needle was pre-cleaned;

[0261] At 2.0 seconds into the 27th cycle, pre-warming of the single-reagent needle was completed;

[0262] At 6.0 seconds into the 27th cycle, the double reagent needle was cleaned and the double reagent needle began to add DD R2 reagent;

[0263] At 6.0 seconds of the 28th cycle, the double reagent needle completes the addition of DD R2 reagent, and the transfer gripper transfers the reaction cup from the test plate to the test mixing position;

[0264] At 7.5 seconds into the 28th cycle, the reaction cup reaches the test mixing position and mixes for 4 seconds;

[0265] At 2.5 seconds into the 29th cycle, the mixing is completed, and the transfer gripper transfers the reaction cup from the test mixing position to the test plate;

[0266] At 3.5 seconds into the 29th cycle, the reaction cup reaches the test plate and begins the test cycle, with a maximum test cycle of 15 cycles;

[0267] At 3.5 seconds into the 44th cycle, the test cycle ended;

[0268] At 8.0 seconds in the 44th cycle, the transfer gripper transfers the reaction cup from the test plate to the cup discarding position;

[0269] At 1.0 second of the 45th cycle, the reaction cup reaches the cup discarding position and enters the waste cup box, and the D-Dimer detection ends.

[0270] Taking a four-item test project as an example, the specific test scheduling process is as follows:

[0271] At 7.0 seconds in cycle 0, the sample rack entry begins;

[0272] At 1.5 seconds of the first cycle, the sample rack was loaded into the rack;

[0273] At 0.0 seconds in the second cycle, the PT task, the sample loading of the sample loading needle begins, and the pre-heating channel (pre-heating position 1) begins to be occupied;

[0274] At 0.0 seconds in the third cycle, the PT task is completed, the sample loading is completed, and the sample preheating begins. The preheating cycle is 24 cycles.

[0275] At 0.0 seconds in the fourth cycle, in the APTT task, the sample injection needle begins to inject samples, and the pre-heating channel (pre-heating position 2) begins to be occupied;

[0276] At 0.0 seconds in the fifth cycle, the APTT task is completed, the sample is loaded by the sample needle, and the sample preheating begins. It needs to be preheated for 4 cycles;

[0277] At 0.0 seconds in the fifth cycle, in the TT task, the sample loading of the sample loading needle begins, and the pre-heating channel (pre-heating position 3) begins to be occupied;

[0278] At 0.0 seconds in the sixth cycle, the TT task, the sample loading is completed, and the sample preheating begins, which requires 24 cycles of preheating;

[0279] At 0.0 seconds in the sixth cycle, the FIB task, the sample loading of the sample loading needle begins, and the pre-heating channel (pre-heating position 4) begins to be occupied;

[0280] At 0.0 seconds in the 7th cycle, the FIB task, the sample loading of the sample needle is completed, and the sample preheating begins, which requires 24 cycles of preheating;

[0281] At 4.5 seconds of the 7th cycle, all the sample needles have completed the sample loading, and there is no other sample loading task required, so the sample rack is withdrawn;

[0282] At 6.5 seconds in the 7th cycle, the sample rack was unloaded;

[0283] At 2.0 seconds in the 8th cycle, APTT task, the single reagent needle pre-cleaning is completed, and the single reagent needle adds APTT reagent into the reaction cup;

[0284] At 0.0 seconds in the 9th cycle, APTT task, sample pre-warming was completed;

[0285] At 2.0 seconds into the 9th cycle, the APTT task was completed by adding the APTT reagent to the reaction cup with the single reagent needle, and the single reagent needle preheating for 19 cycles was started;

[0286] At 4.0 seconds in the 25th cycle, the PT task is transferred from the pre-warming plate to the test plate (test position 1);

[0287] At 6.0 seconds in the 25th cycle, the PT task, the transfer from the pre-warming tray to the test tray, is completed, and the reaction cup arrives at the test tray (test position 1);

[0288] At 6.0 seconds in the 26th cycle, PT task, the double reagent needle was pre-cleaned;

[0289] At 0.0 seconds in the 27th cycle, the PT task, sample pre-warming was completed;

[0290] At 4.0 seconds in the 27th cycle, the APTT task was transferred from the pre-warming plate to the test plate (test position 2);

[0291] At 6.0 seconds in the 27th cycle, the APTT task was completed by transferring from the pre-warming tray to the test tray, and the reaction cup arrived at the test tray (test position 2);

[0292] At 6.0 seconds in the 27th cycle, PT task, the double reagent needle front cleaning is completed, and the double reagent needle begins to add PT reagent;

[0293] At 4.0 seconds in the 28th cycle, the TT task is transferred from the pre-warming plate to the test plate (test position 3);

[0294] At 6.0 seconds of the 28th cycle, the PT task, the addition of PT reagents to the double reagent needle is completed, and the test cycle begins. The maximum test cycle is 15 cycles;

[0295] At 6.0 seconds in the 28th cycle, the TT task, the transfer from the pre-warming tray to the test tray, is completed, and the reaction cup arrives at the test tray (test position 3);

[0296] At 6.0 seconds in the 28th cycle, APTT task, the double reagent needle was pre-cleaned;

[0297] At 2.0 seconds in the 29th cycle, APTT task, single reagent needle pre-warming was completed;

[0298] At 4.0 seconds in the 29th cycle, the FIB task is transferred from the pre-warming plate to the test plate (test position 4);

[0299] At 6.0 seconds in the 29th cycle, the FIB task,transfer from the pre-heating tray to the test tray is completed, and the reaction cup arrives at the test tray (test position 4);

[0300] At 6.0 seconds in the 29th cycle, APTT task, the double reagent needle front cleaning was completed, and the double reagent needle began to add CaCl2 reagent;

[0301] At 6.0 seconds in the 29th cycle, TT task, the double reagent needle was pre-cleaned;

[0302] At 0.0 seconds in the 30th cycle, TT task, sample pre-warming is completed;

[0303] At 6.0 seconds in the 30th cycle, APTT task, the double reagent needle added CaCl2 reagent and the transfer gripper transferred the reaction cup from the test plate to the test mixing position;

[0304] At 6.0 seconds in the 30th cycle, TT task, the double reagent needle front cleaning is completed, and the double reagent needle begins to add TT reagent;

[0305] At 7.5 seconds in the 30th cycle, the APTT task, the reaction cup reached the test mixing position and mixed for 4 seconds;

[0306] At 0.0 seconds in the 31st cycle, FIB task, sample pre-warming is completed;

[0307] At 2.5 seconds in the 31st cycle, the APTT task, the mixing is completed, and the transfer gripper transfers the reaction cup from the test mixing position to the test plate;

[0308] At 3.5 seconds of the 31st cycle, in the APTT task, the reaction cup reaches the test plate and begins to enter the test cycle, with a maximum test cycle of 15 cycles;

[0309] At 6.0 seconds in the 31st cycle, the TT task, the double reagent needle adding TT reagent is completed, and the transfer gripper transfers the reaction cup from the test plate to the test mixing position;

[0310] At 6.0 seconds in the 31st cycle, FIB task, the double reagent needle began to add FIB reagent;

[0311] At 7.5 seconds in the 31st cycle, in the TT task, the reaction cup reaches the test mixing position and mixes for 4 seconds;

[0312] At 2.5 seconds in the 32nd cycle, the TT task, the mixing is completed, and the transfer gripper transfers the reaction cup from the test mixing position to the test plate;

[0313] At 3.5 seconds of the 32nd cycle, in the TT task, the reaction cup reaches the test plate and begins to enter the test cycle, with a maximum test cycle of 15 cycles;

[0314] At 6.0 seconds in the 32nd cycle, FIB task, the double reagent needle adds FIB reagent and the transfer gripper transfers the reaction cup from the test plate to the test mixing position;

[0315] At 7.5 seconds in the 32nd cycle, FIB task, the reaction cup reaches the test mixing position and mixes for 4 seconds;

[0316] At 2.5 seconds in the 33rd cycle, the FIB task, mixing is completed, and the transfer gripper transfers the reaction cup from the test mixing position to the test plate;

[0317] At 3.5 seconds of the 33rd cycle, in the FIB task, the reaction cup reaches the test plate and begins to enter the test cycle, with a maximum test cycle of 15 cycles;

[0318] At 6.0 seconds in the 43rd cycle, the PT task, the test cycle ends;

[0319] At 8.0 seconds in the 43rd cycle, in the PT task, the transfer gripper transfers the reaction cup from the test tray to the cup discarding position;

[0320] At 1.0 seconds in the 44th cycle, in the PT task, the reaction cup reaches the discarding position and enters the waste cup box, and the task ends;

[0321] At 3.5 seconds of the 46th cycle, the APTT task, the test cycle ended;

[0322] At 8.0 seconds in the 46th cycle, in the APTT task, the transfer gripper transfers the reaction cup from the test tray to the cup discarding position;

[0323] At 1.0 second of the 47th cycle, in the APTT task, the reaction cup reaches the discarding position and enters the waste cup box, and the experiment ends;

[0324] At 3.5 seconds of the 47th cycle, the TT task, the test cycle ended;

[0325] At 8.0 seconds in the 47th cycle, in the TT task, the transfer gripper transfers the reaction cup from the test tray to the cup discarding position;

[0326] At 1.0 seconds in the 48th cycle, in the TT task, the reaction cup reaches the cup discarding position and enters the waste cup box, and the task ends;

[0327] At 6.0 seconds in the 48th cycle, the FIB task,test cycle ends;

[0328] At 8.0 seconds in the 48th cycle, in the FIB task, the transfer gripper transfers the reaction cup from the test plate to the cup discarding position;

[0329] At 1.0 second of the 49th cycle, the FIB task reaction cup reaches the cup discarding position and enters the waste cup box, and the task ends.

[0330] In summary, the coagulation analyzer operating system software in this application can reach a detection speed of 420 tests / hour (PT, APTT, TT, FIB, D-Dimer projects) in one hour through the detection project task scheduling scheme, which improves the test speed of the comprehensive detection project of the coagulation analyzer. Among them, the sample detection of four coagulation items (1 sample simultaneously detects PT, APTT, TT, FIB) can detect 100 samples in one hour, and the sample detection of five coagulation items (1 sample simultaneously detects PT, APTT, TT, FIB, D-Dimer) can detect 80 samples in one hour, which can meet the rapid detection needs of batch samples of clinical testing institutions.

[0331] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0332] Professionals may further appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, computer software, or a combination of the two. In order to clearly illustrate the interchangeability of hardware and software, the composition and steps of each example have been generally described in the above description according to function. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professionals and technicians may use different methods to implement the described functions for each specific application, but such implementation should not be considered to be beyond the scope of this application.

[0333] The steps of the method or algorithm described in conjunction with the embodiments disclosed herein may be implemented directly using hardware, a software module executed by a processor, or a combination of the two. The software module may be placed in a random access memory (RAM), a memory, a read-only memory (ROM), an electrically programmable ROM, an electrically erasable programmable ROM, a register, a hard disk, a removable disk, a CD-ROM, or any other form of storage medium known in the art.

[0334] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A control method for sample detection in a coagulation analyzer, characterized in that: The coagulation analyzer comprises a plurality of sample racks, one of the sample racks comprises a plurality of wells, one of the wells is used to place a tube of sample, and the method comprises: Controlling a first sample rack in the coagulation analyzer to move from a sample position to a sample suction position corresponding to a sample adding needle, wherein a first sample is placed in a hole of the first sample rack, and the first sample is used to detect a first item; For each well in the first sample rack, the following processes are performed in sequence: Controlling the sample adding needle in the coagulation analyzer to draw the first sample from the well position and add the first sample into the reaction cup at the sample arrangement position, wherein the number of the reaction cups is consistent with the number of the well positions; Controlling the reaction cup to enter a pre-heating position in the pre-heating tray of the coagulation analyzer, so that the sample in the reaction cup enters a pre-heating state; the number of pre-heating positions in the pre-heating tray is greater than the number of holes in the sample rack; When the duration of the reaction cup being in the preheating state reaches the preheating duration corresponding to the first item, controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer; the number of test positions in the test tray is greater than the number of holes in the sample rack; Controlling a first reagent needle of the coagulation analyzer to add a first reagent corresponding to the first item into the reaction cup; When the duration of adding the first reagent to the reaction cup reaches the test duration corresponding to the first item, controlling the reaction cup to enter the cup discarding position; Before controlling the first reagent needle to add the first reagent into the reaction cup corresponding to the first well in the first sample rack, the method further includes: Determine whether a second sample in a second sample rack in the coagulation analyzer is used to detect a second item; the second sample rack is a sample rack that is moved to the sample suction position before the first sample rack, and the second item is different from the first item; If the second sample in the second sample rack is used to detect the second item, cleaning the first reagent needle; Wherein, controlling the first sample rack in the coagulation analyzer to move from the sample position to the preset sample suction position includes: At a first time point in a first time period, controlling a first sample rack in the coagulation analyzer to start moving from a sample position to a preset sample suction position, so that the first sample rack reaches the sample suction position at a second time point in a second time period, the second time period being a time period after the first time period; Wherein, after controlling the sample adding needle to absorb the first sample from the last hole in the first sample rack, the method further includes: At a third time point in a third time period, controlling the first sample rack to move from the sample suction position to the sample position, so that the first sample rack reaches the sample position at a fourth time point in the third time period; The fourth time point is smaller than the first time point.

2. The method according to claim 1, characterized in that The coagulation analyzer corresponds to a time period for detection control, and the time period is 8.5 seconds.

3. The method according to claim 2, characterized in that The step of controlling the sample adding needle in the coagulation analyzer to draw the first sample from the hole and adding the first sample into the reaction cup at the sample discharging position comprises: At a fifth time point in the fourth time period, controlling the sample adding needle of the coagulation analyzer to start drawing the first sample from the well position and adding the first sample to the reaction cup at the sample discharging position, so that the first sample is added completely at a fifth time point in the fifth time period; The fifth time period is a time period after the fourth time period, and after a fifth time point in the fifth time period, the sample adding needle can be used to absorb the corresponding first sample from other wells.

4. The method according to claim 3, characterized in that The method further comprises: At a fifth time point in the fourth time period, a corresponding pre-heating position is configured for the hole position in the pre-heating tray, so that the pre-heating position starts to wait for the reaction cup corresponding to the hole position to enter from the fifth time point in the fourth time period; After the reaction cup corresponding to the well position enters the testing position from the pre-heating position, the pre-heating position waits to be configured as the pre-heating position corresponding to other well positions.

5. The method according to claim 2, characterized in that: The step of cleaning the first reagent needle comprises: At the sixth time point of the sixth time period, the first reagent needle begins to be cleaned, so that the first reagent needle is completely cleaned at the sixth time point of the seventh time period; The seventh time period is a time period after the sixth time period.

6. The method according to claim 2, characterized in that When the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the first item, before controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer, the method further includes: At the seventh time point of the eighth time period, controlling the second reagent needle to add the second reagent corresponding to the first item into the reaction cup; When the duration of the reaction cup being in the preheating state reaches the preheating time corresponding to the second reagent, the steps of: controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer; Wherein, controlling the reaction cup to enter a test position in the test tray of the coagulation analyzer comprises: At an eighth time point in a ninth time period, the reaction cup begins to be moved from the pre-heating position to the testing position by using a transfer gripper, so that the reaction cup reaches the testing position at a ninth time point in the ninth time period.

7. The method according to claim 6, characterized in that Before controlling the second reagent needle to add the second reagent corresponding to the first item into the reaction cup corresponding to the first well in the first sample rack, the method further includes: Determining whether the second sample in the second sample rack is used to detect a second item; If the second sample in the second sample rack is used to detect the second item, the second reagent needle of the coagulation analyzer is started to be cleaned at the seventh time point of the tenth time cycle, so that the second reagent needle is cleaned at the seventh time point of the eighth time cycle, and the eighth time cycle is the time period after the tenth time cycle.

8. The method according to claim 2, characterized in that: After controlling the first reagent needle of the coagulation analyzer to add the first reagent corresponding to the first item into the reaction cup, the method further includes: At the tenth time point in the eleventh time period, the reaction cup begins to be moved from the test position to the test mixing position by using a transfer gripper, so that the reaction cup reaches the test mixing position at the eleventh time point in the eleventh time period; When the duration of the reaction cup being in the test mixing position reaches the mixing time corresponding to the first reagent, at the eleventh time point of the twelfth time period, the reaction cup is moved from the test mixing position to the test position by using a transfer gripper, so that the reaction cup reaches the test position at the twelfth time point of the twelfth time period; Wherein, when the duration of the reaction cup being in the test position reaches the test duration corresponding to the first item, controlling the reaction cup to enter the cup discarding position includes: At the thirteenth time point in the thirteenth time period, the reaction cup begins to be moved from the testing position to the cup discarding position by using a transfer gripper, so that the reaction cup reaches the cup discarding position at the fourteenth time point in the fourteenth time period.

9. A coagulation analyzer, characterized in that: The coagulation analyzer adopts the control method for sample detection in a coagulation analyzer according to any one of claims 1 to 8, and the coagulation analyzer comprises: A plurality of sample racks, wherein one of the sample racks comprises a plurality of wells, and one of the wells is used to place a tube of sample; Sample needle; First reagent needle; A plurality of reaction cups, wherein the number of the reaction cups is greater than the number of wells in the sample rack; A pre-heating plate comprising a plurality of pre-heating positions, wherein the number of the pre-heating positions is greater than the number of wells in the sample rack; A test tray comprising a plurality of test positions, wherein the number of the test positions is greater than the number of wells in the sample rack; Lost cup position; A controller, used to: control a first sample rack to move from a sample position to a preset sample suction position, wherein a first sample is placed in a hole of the first sample rack, and the first sample is used to detect a first item; The controller sequentially executes the following processes for each well in the first sample rack: Controlling the sample adding needle to absorb the first sample from the well position and add the first sample into the reaction cup at the sample arrangement position, the number of the reaction cups being consistent with the number of the well positions; Controlling the reaction cup to enter a pre-heating position in the pre-heating tray so that the sample in the reaction cup enters a pre-heating state; When the duration of the reaction cup being in the preheating state reaches the preheating duration corresponding to the first item, controlling the reaction cup to enter a testing position in the test tray; controlling the first reagent needle to add the first reagent corresponding to the first item into the reaction cup; When the duration of the reaction cup being in the test position reaches the test duration corresponding to the first item, the reaction cup is controlled to enter the cup discarding position.

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