A device for mouse experiment and method of using the same

Abstract

The present application discloses a device for mouse experiment and a method of using the device, and relates to the technical field of mouse experiment. The skeleton comprises a first bottom plate, arc-shaped curved sections at both ends of the first bottom plate, and a plastic arc-shaped skeleton, and the two ends of the arc-shaped curved sections and the two ends of the plastic arc-shaped skeleton are connected by mortise and tenon joints; the plastic metal wire is bent as a whole into the same arc as the plastic arc-shaped skeleton, the plastic arc-shaped skeleton and a plurality of plastic metal wires are located in a cover body, and a plurality of external pulling ropes are provided at hook-shaped structures close to the plastic metal wires on both sides of the first bottom plate; the cover body, a plurality of plastic arc-shaped skeletons, a plurality of arc-shaped curved sections of the plastic metal wires and the first bottom plate form a tunnel structure, one end of the tunnel structure is a cover surface, and the other end is a tightening cover, and the cover surface is hingedly connected to the skeleton of the tunnel structure; a closable opening surface is provided on the upper part of one end of the cover body close to the cover surface; the present application realizes that mice are easy to capture, and anesthetic injection and oral operation after capture are convenient, and can adapt to different operation processes.

Description

Technical Field

[0001] The present application relates to the field of mouse experiment technology, and in particular to a device for mouse experiment and a method of using the same. Background Art

[0002] Mice are rodents belonging to the order Rodentia and the family Muridae. They are commonly known as "rats". They reproduce by giving birth to live young and are the fastest-growing mammals with the strongest survival ability. There are about 480 species of mice in the world, and their footprints can be seen both indoors and outdoors.

[0003] Since mice and humans are both mammals, especially mice, which have the same organs and genes as humans, and mice are smaller, any drugs or other experimental operations will quickly show up in mice. Therefore, mice are often used as experimental subjects in various medical experiments.

[0004] In various medical experiments, including oral and dental experiments, first of all, scientific research often requires capturing live mice as experimental subjects, and then injecting them with anesthetics to facilitate the next experimental operation. However, the technology of capturing mice in most mouse oral experimental devices is relatively simple, and it is not convenient to inject anesthetics after capture, which is not convenient for the subsequent oral surgery operation. The purpose of mouse experimental devices is single. Summary of the invention

[0005] The embodiment of the present invention provides a mouse experimental device and a method for using the same, thereby solving the problem that most current mouse oral experimental devices have a relatively simple technique for capturing mice, are inconvenient for anesthetic injection after capture, and are thus inconvenient for subsequent oral surgery, and that the mouse experimental device has a single purpose. The embodiment of the present invention makes it easy to capture mice, and anesthetic injection and oral surgery are convenient after capture. In addition, the experimental device of the present invention has multiple functions and can adapt to different operating processes.

[0006] In a first aspect, an embodiment of the present invention provides a device for mouse experiments, comprising a first bottom plate, a frame, a plastic metal wire, a cover body, a cover surface, and a tightening cover;

[0007] The frame is an arc-shaped structure as a whole, and comprises a first bottom plate, arc-shaped curved sections at both ends of the first bottom plate, and a plastic arc-shaped frame, and both ends of the arc-shaped curved sections and both ends of the plastic arc-shaped frame are connected by mortise and tenon joints;

[0008] The plurality of plastic metal wires are integrally bent into the same curvature as the plastic arc-shaped frame, the plurality of plastic metal wires and at least two plastic arc-shaped frames are arranged transversely, and the plastic arc-shaped frames and the plurality of plastic metal wires are located in the cover body;

[0009] A plurality of connection rings for connecting the plastic metal wire are arranged on both sides of the first bottom plate, and both ends of the plastic metal wire are hook-shaped structures, and the hook-shaped structures are hooked at the connection rings; the plastic metal wire is movably connected inside the cover body and can be pulled inside the cover body; a plurality of external pulling ropes are arranged on both sides of the first bottom plate near the hook-shaped structures of the plastic metal wire;

[0010] The cover body, the plurality of the plastic arc-shaped skeletons, the arc-shaped curved sections of the plurality of the plastic metal wires and the first bottom plate form a tunnel structure, one end of the tunnel structure is a cover surface, and the other end is a tightening cover, the cover surface is hingedly connected to the skeleton of the tunnel structure; a closable opening surface is provided on the upper part of the cover body near the cover surface end.

[0011] In combination with the first aspect, in a possible implementation manner, a second bottom plate is provided at the bottom of the first bottom plate, a supporting leg is provided at the bottom of the second bottom plate, and an area of ​​the second bottom plate is larger than an area of ​​the first bottom plate;

[0012] A protruding structure is provided at the bottom of the first bottom plate, and a groove is provided at a corresponding position of the second bottom plate, and the protruding structure is clamped in the groove.

[0013] In combination with the first aspect, in a possible implementation manner, one end of the tightening cover is connected to the plastic arc-shaped frame, and an internal pulling rope is provided inside the tightening cover.

[0014] In combination with the first aspect, in a possible implementation, a square block is provided on one end of the first bottom plate close to the cover surface, the square block is slidably connected to the first bottom plate, and the square block slides on the first bottom plate along the transverse direction of the first bottom plate.

[0015] In combination with the first aspect, in a possible implementation, it further includes a clamping mechanism, the clamping mechanism as a whole is an inverted "F"-shaped structure, and the inverted "F"-shaped structure includes a vertical support rod and an integrated clamping portion, the clamping portion is used to clamp the first bottom plate, and when in use, the clamping portion is located at a side position of the mouse's oral cavity on the first bottom plate;

[0016] The vertical support rod is provided with lighting lamps and three-arm structures at different heights, the height of the lighting lamp is higher than the height of the three-arm structure, and the lighting lamp and the three-arm structure are connected on the vertical support rod by a cross clamp that can be moved in multiple directions.

[0017] In combination with the first aspect, in a possible implementation, the three-arm structure includes a movable connecting end, an upper arm, a lower arm and an intermediate arm; one end of the upper arm, the lower arm and the intermediate arm are all connected in different directions of the movable connecting end, and one end of the upper arm, the lower arm and the intermediate arm away from the movable connecting end is a free end; the movable connecting end is connected to the vertical support rod through a connecting rod and the cross clamp;

[0018] The upper arm and the lower arm have the same and symmetrical structures, and the length of the middle arm is shorter than that of the upper arm and the lower arm.

[0019] In combination with the first aspect, in a possible implementation, the overall structure of the upper arm is that the movable connection end of the upper arm starts to move away from the middle arm, then moves closer to the middle arm, and finally moves away from the middle arm;

[0020] The upper arm includes a first curved section and a second curved section, the first curved section and the second curved section are integrated and continuous, and the bending directions of the first curved section and the second curved section are opposite; the lower arm and the upper arm have the same structure and are symmetrically arranged on both sides of the middle arm; the middle arm is straight as a whole, and an arc-shaped hook is provided at the free end of the middle arm.

[0021] In combination with the first aspect, in a possible implementation, the movable connection end is a wire loop in different directions, and the length and direction of the wire loop are adjustable.

[0022] In a second aspect, an embodiment of the present invention provides a method for using a mouse experiment device, wherein using the above-mentioned mouse experiment device comprises the following steps:

[0023] Opening the cover of the tunnel structure and tightening the cover to allow the mouse to drill into the tunnel structure;

[0024] Closing the cover, straightening the free end connection of the plastic metal wire, and pulling out the plastic metal wire, thereby disassembling the plastic metal wire;

[0025] The mouse is tied up by the external pulling rope, the opening surface on the cover is opened, and anesthesia is injected into the abdominal cavity of the mouse;

[0026] Open the cover, disassemble the cover body and the plastic arc-shaped frame, change the position of the mouse so that the head of the mouse is close to one end of the cover and the mouse lies on its back, and fix the limbs of the mouse using the external pulling rope on the first bottom plate;

[0027] The lid is half-closed to lift the mouse's head, and surgery is performed on the mouse's oral cavity.

[0028] In combination with the second aspect, in a possible implementation manner, when the tightening cover is tightened, a small hole is left in front of the tightening cover.

[0029] One or more technical solutions provided in the embodiments of the present invention have at least the following technical effects or advantages:

[0030] The mouse experiment device of the present invention utilizes the characteristic that mice love to drill holes, and configures a tunnel structure through a first bottom plate, an arc-shaped curved section, a plastic arc-shaped frame, and a plastic metal wire. The arc-shaped frame and the plastic metal wire support a cover body, and utilize the environment that mice like tunnel structures to facilitate the capture of mice. When the mouse drills into the tunnel structure, the cover is closed. Since the plastic metal wire is movably connected inside the cover body and can be pulled out inside the cover body, the plastic metal wire is pulled out, and then the shape of the cover body changes due to the lack of the supporting effect of the plastic metal wire. Then, the external pulling rope designed at both ends of the first bottom plate is used in combination with the cover body to capture and fix the mouse, so as to prevent the mouse from moving too much when injecting anesthetics to the mouse, and the specific injection of anesthetics is to open the cover body. The closable opening surface at the upper part near the cover end is used to inject anesthetics into mice. After the injection is completed, since the two ends of the arc-shaped curved section and the two ends of the plastic arc-shaped skeleton are connected by mortise and tenon joints, that is, after the functions of capturing the mouse and injecting anesthetics are completed, the plastic arc-shaped skeleton is detachable, and the next step of mouse operation is carried out by disassembling the plastic arc-shaped skeleton and the device behind the cover body, which effectively solves the problem that the technology of capturing mice by the mouse oral experimental device is relatively simple, it is not convenient to inject anesthetics after capturing, and thus it is not convenient for the subsequent oral surgery operation, and the problem that the mouse experimental device has a single purpose, thereby achieving the convenience of capturing mice, and the anesthetic injection and oral operation after capturing are convenient. The experimental device of the present invention has multiple functions and can adapt to different operation processes.

[0031] The method for using the mouse experiment device of the present invention can adapt to structural changes in different steps when used, has various functions, and only one such device is needed from beginning to end to basically complete the entire operation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments of the present invention or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0033] Figure 1 A schematic diagram of the skeleton of the mouse experiment device provided in an embodiment of the present invention;

[0034] Figure 2 A schematic diagram of the structure of a device for mouse experiments provided in an embodiment of the present invention;

[0035] Figure 3 Schematic diagram of the operating structure of the mouse experiment device provided in an embodiment of the present invention Figure 1 ;

[0036] Figure 4 Schematic diagram of the operating structure of the mouse experiment device provided in an embodiment of the present invention Figure 2 ;

[0037] Figure 5 A schematic diagram of the clamping mechanism of the mouse experiment device provided in an embodiment of the present invention, and the lighting lamp and three-arm structure installed therein;

[0038] Figure 6 A diagram showing the usage status of the three-arm structure of the mouse experiment device provided in an embodiment of the present invention.

[0039] Icons: 1-skeleton; 11-plastic arc-shaped skeleton; 12-arc-shaped bending section; 2-cover body; 21-closable opening surface; 3-cover surface; 4-tightening cover; 5-external pulling rope; 6-plastic metal wire; 7-first bottom plate; 8-second bottom plate; 9-square block; 10-clamping mechanism; 101-vertical support rod; 102-clamping part; 16-lighting lamp; 121-upper arm; 122-lower arm; 123-middle arm; 13-cross clamp; 14-movable connecting end; 15-mouse mouth. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] In the description of the embodiments of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present invention and simplifying the description, rather than indicating or implying that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limitations on the present invention. The terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance. In addition, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present invention can be understood according to the specific circumstances.

[0042] Reference Figure 1-6 As shown, an embodiment of the present invention provides a device for mouse experiments, comprising a first bottom plate 7, a frame 1, a plastic metal wire 6, a cover body 2, a cover surface 3 and a tightening cover 4;

[0043] The skeleton 1 is an arc-shaped structure as a whole, and the skeleton 1 includes a first bottom plate 7, arc-shaped curved sections 12 at both ends of the first bottom plate 7, and a plastic arc-shaped skeleton 11, and the two ends of the arc-shaped curved section 12 and the two ends of the plastic arc-shaped skeleton 11 are connected by mortise and tenon joints; in the embodiment of the present invention, a groove is provided on the arc-shaped curved section 12, and a convex structure is provided at both ends of the plastic arc-shaped skeleton 11, and the overall width of the convex structure is greater than the width of other parts of the arc-shaped curved section 12 itself, thereby further ensuring the tightness of the mortise and tenon joint connection; the arc-shaped curved section 12 and the cover body 2 are both made of PVC material; in particular, the cover body 2 is made of transparent PVC material, which makes it easier to observe the state of the mouse inside the cover body 2;

[0044] The plurality of plastic metal wires 6 are bent as a whole into the same curvature as the plastic arc-shaped frame 11. The plastic metal wires 6 here can be iron wires. The plurality of plastic metal wires 6 and at least two plastic arc-shaped frames 11 are arranged transversely. The plastic arc-shaped frames 11 and the plurality of plastic metal wires 6 are located in the cover body 2 and are used to support the cover body 2.

[0045] A plurality of connecting rings for connecting the plastic metal wire 6 are provided on both sides of the first bottom plate 7, and both ends of the plastic metal wire 6 are hook-shaped structures, and the hook-shaped structures are hooked at the connecting rings; the plastic metal wire 6 is movably connected inside the cover body 2, that is, a cavity for the plastic metal wire 6 to pass through is provided inside the cover body 2, and the plastic metal wire 6 can be pulled out of the cavity inside the cover body 2; when the hook of the plastic metal wire 6 plays a supporting role, it is located in the cavity inside the cover body 2, and when no support is needed, the hook of the plastic metal wire 6 can be processed and the plastic metal wire 6 can be pulled out of the cover body 2, and a plurality of external pulling ropes 5 are also provided on both sides of the first bottom plate 7 near the hook-shaped structures of the plastic metal wire 6, and the external pulling ropes 5 can be used later;

[0046] The cover body 2, multiple plastic arc-shaped skeletons 11, multiple arc-shaped bending sections 12 of plastic metal wires 6 and the first bottom plate 7 form a tunnel structure, one end of the tunnel structure is a cover surface 3, and the other end is a tightening cover 4, and the cover surface 3 is hingedly connected to the skeleton 1 of the tunnel structure; the conventional hinge connection method in the prior art, such as zipper connection, can be adopted, when the cover surface 3 is a hard material, the connection between the cover surface 3 and the plastic arc-shaped skeleton 11 and the arc-shaped bending section 12 can be made of PVC material or cloth, which is convenient for zipper connection; in addition, the cover surface is a hard material, and a hinge connection method similar to that of a laptop computer can also be adopted, and the upper port is closed after it is directly covered with the plastic arc-shaped skeleton 11; the specific connection method can be selected according to the specific situation, as long as the cover surface 3 and the cover body 2 can be sealed; a closable opening surface 21 is provided on the upper part of one end of the cover body 2 close to the cover surface 3.

[0047] The embodiment of the present invention utilizes the environment that mice like tunnel structures to facilitate the capture of mice. When the mouse drills into the tunnel structure, the cover 3 is closed. Since the plastic wire 6 is movably connected inside the cavity of the cover body 2 and can be pulled out inside the cavity of the cover body 2, the plastic wire 6 is pulled out, and the shape of the cover body 2 changes due to the lack of the support of the plastic wire 6. Then, the external pulling rope 5 designed at both ends of the first bottom plate 7 is used in combination with the cover body 2 to capture and fix the mouse, so as to prevent the mouse from moving too much when injecting anesthetics to the mouse, and the specific injection of anesthetics is to open the closable opening surface 21 on the upper part of the cover body 2 near the end of the cover 3, and inject the anesthetic into the mouse through the closable opening surface 21. Anesthetic is injected. After the injection is completed, since the two ends of the arc-shaped curved section 12 and the two ends of the plastic arc-shaped frame 11 are connected by mortise and tenon joints, that is, after the function of capturing the mouse and injecting anesthetic is completed, the plastic arc-shaped frame 11 is detachable. The next step of mouse operation is carried out by disassembling the plastic arc-shaped frame 11 and the device behind the cover body 2, which effectively solves the problem that the technology of capturing mice by the mouse oral experimental device is relatively simple, it is not convenient to inject anesthetics after capturing, and thus it is not convenient for the subsequent oral surgery operation, and the problem that the mouse experimental device has a single purpose, thereby achieving the convenience of capturing mice, and the anesthetic injection and oral operation after capturing are convenient. The experimental device of the present invention has multiple functions and can adapt to different operating processes.

[0048] Optionally, a second bottom plate 8 is provided at the bottom of the first bottom plate 7, and supporting legs are provided at the bottom of the second bottom plate 8. The area of ​​the second bottom plate 8 is larger than that of the first bottom plate 7, and the first bottom plate 7 is located in the middle part of the second bottom plate 8. A protruding structure is provided at the bottom of the first bottom plate 7, and a groove is provided at the corresponding position of the second bottom plate 8. The protruding structure is stuck in the groove. This can ensure the stability of the first bottom plate 7 and prevent the mouse from moving around after drilling into the tunnel structure and before being fixed and injected with anesthetics, thereby preventing the first bottom plate 7 from becoming unstable. In addition, the second bottom plate 8 and the supporting legs serve as a mouse operating platform, which is convenient for operation.

[0049] Optionally, one end of the tightening cover 4 is connected to the plastic arc-shaped frame 11, and an internal pulling rope is provided inside the tightening cover 4. The tightening cover 4 is also made of PVC material. When a mouse enters the tunnel structure from one end of the cover surface 3, it is difficult for the mouse to escape due to the protective effect of the tightening cover 4, the cover surface 3 and the cover body 2, thereby facilitating the next step of operation. The tightening cover 4 is very convenient to operate, and the entire tunnel structure is convenient for quickly capturing mice, saving time.

[0050] Optionally, a square block 9 is provided on one end of the first bottom plate 7 near the cover surface 3, and the square block 9 is slidably connected to the first bottom plate 7, and the square block 9 slides on the first bottom plate 7 along the lateral direction of the first bottom plate 7 (the lateral direction here refers to the lateral direction of the tunnel structure). When injecting anesthetics into mice, the square block 9 can be pushed and pulled through the opening where the closable opening surface 21 is located to adjust the intraperitoneal injection site of the mouse, so as to more accurately inject into the intraperitoneal area. The square block 9 and the first bottom plate 7 are slidably connected. For example, the first bottom plate 7 is provided with a long strip groove in the direction in which the square block 9 needs to slide, and the square block 9 is provided with a corresponding long strip protrusion at the position connecting the long strip groove, and the length of the long strip groove is greater than the length of the long strip protrusion, so that the square block 9 can slide freely along the length direction of the long strip groove on the first bottom plate 7, and at the same time, the square block 9 is limited in the length direction of the long strip groove to prevent the square block 9 from changing too much, and at the same time, the height of the square block 9 is limited to be higher than the upper plane of the first bottom plate 7, thereby playing a role in raising the abdominal cavity of the mouse, so as to better find the abdominal injection site when the mouse is lying prone.

[0051] After the anesthetic is injected into the mouse, the body position of the mouse can be adjusted so that the mouse lies on its back with its head close to the position of the cover 3, and the limbs of the mouse are tied up with an external pulling rope 5, and the cover 3 is slightly lifted. The cover 3 can be made of hard material. When the cover 3 is half-lifted, the end away from the closed surface is supported by other tools, so that the head of the mouse is tilted back to prevent it from being swallowed by mistake. At the same time, the square block 9 also has a certain cushioning effect on the back of the mouse, which can adjust the position of the upper body of the mouse, and thus better adjust the position of the mouse's mouth.

[0052] Optionally, it also includes a clamping mechanism 10, which is an inverted "F"-shaped structure as a whole, and the inverted "F"-shaped structure includes a vertical support rod 101 and an integrated clamping portion 102, the clamping portion 102 is used to clamp the first bottom plate 7, when in use, the clamping portion 102 is located at the side of the mouse mouth on the first bottom plate 7; different heights of the vertical support rod 101 are provided with lighting lamps 16 and a three-arm structure, wherein Figure 5 The dotted line indicates the location where the lighting lamp 16 and the three-arm structure are installed; the height of the lighting lamp 16 is higher than the height of the three-arm structure, and the lighting lamp 16 and the three-arm structure are connected on the vertical support rod 101 through a cross clamp 13 that can be moved in multiple directions. The clamping part 102 clamps the entire clamping mechanism 10 on the first bottom plate 7. The multi-directional cross clamp 13 on the vertical support rod 101 of the clamping mechanism 10 can adjust the lighting lamp 16 and the three-arm structure up and down, and can also adjust the angle of the lighting lamp 16 and the three-arm structure. The lighting lamp 16 facilitates the observation of the operation process of the mouse oral surgery. The three-arm structure is used as a tool to pry open the mouse's mouth, making the experimental surgery convenient.

[0053] Optionally, the three-arm structure includes a movable connecting end 14, an upper arm 121, a lower arm 122 and a middle arm 123; one end of the upper arm 121, the lower arm 122 and the middle arm 123 are all connected to the movable connecting end 14 in different directions, and the ends of the upper arm 121, the lower arm 122 and the middle arm 123 away from the movable connecting end 14 are free ends; the movable connecting end 14 is connected to the vertical support rod 101 through a cross clamp 13; the structures of the upper arm 121 and the lower arm 122 are the same and symmetrical, and the length of the middle arm 123 is shorter than that of the upper arm 121 and the lower arm 122. Among them, the upper arm 121 and the lower arm 122 are used as the parts to pry open the mouse's teeth, and the middle arm 123 pulls the corners of the mouse's mouth. The movable connecting end 14 can adjust the positional relationship between the upper arm 121, the lower arm 122 and the middle arm 123, so that the three-arm structure meets the oral requirements of the mouse.

[0054] Optional, continue to refer to Figure 5 As shown, the overall structure of the upper arm 121 is that it starts from the movable connecting end 14 away from the middle arm 123, then approaches the middle arm 123, and finally away from the middle arm 123; the upper arm 121 includes a first curved section and a second curved section, the first curved section and the second curved section are integrated and continuous, and the bending directions of the first curved section and the second curved section are opposite; the lower arm 122 has the same structure as the upper arm 121 and is symmetrically arranged on both sides of the middle arm 123; the middle arm 123 is straight as a whole, and an arc-shaped hook is provided at the free end of the middle arm 123. The first curved section and the second curved section of the upper arm 121 are integrated and continuous, and the bending directions of the first curved section and the second curved section are defined, which is more suitable for the oral cavity of mice, wherein the second curved section is the curved section in contact with the teeth of mice, and the free end of the second curved section is designed to be inclined with an arc, refer to Figure 6 As shown, when the three-arm structure is located at the mouse mouth 15, the mouse's teeth are just located in the groove of the second curved section, and the two sides of the second curved section have a certain limiting function for the mouse's teeth, which is convenient for operation.

[0055] In addition, it should be noted that the above-mentioned cross clamp 13 which can be moved in multiple directions may include a vertical support rod 101 and a movable rod body in a specific structure. The vertical support rod 101 and the movable rod body are cross-intersected. A first movable ring is sleeved and connected to the vertical support rod 101. The first movable ring can rotate on the vertical support rod 101 and move up and down. At the same time, the first movable ring is rotatably connected to the second movable ring. The movable rod body is sleeved in the second movable ring. The movable rod body can achieve up and down angular position changes when the second movable ring rotates. The movable rod body is connected to a three-arm structure. At the same time, the first movable ring can also achieve changes in the surrounding directions during the rotation of the vertical support rod 101. When the first movable ring moves up and down during the vertical support rod 101, the three-arm structure can achieve up and down position changes. In actual operation, Figure 5The three-arm structure in the middle is rotated to the same side as the lighting lamp 16.

[0056] Optionally, the movable connecting end 14 is a wire loop in different directions, and the length and direction of the wire loop are adjustable. It should be noted that the wire loop is designed to be able to manually adjust the angle of the three-arm structure, but when the three-arm structure is located in the mouth of the mouse, the angle will not change due to the force in the mouth of the mouse, or the change is very small and can be ignored.

[0057] The embodiment of the present invention also provides a method for using the mouse experiment device, and using the above-mentioned mouse experiment device includes the following steps:

[0058] Open the cover 3 of the tunnel structure and tighten the tightening cover 4 to allow the mouse to drill into the tunnel structure;

[0059] Close the cover 3, straighten the free end connection of the plastic metal wire 6, and pull out the plastic metal wire 6, so as to remove the plastic metal wire 6;

[0060] The mouse is tied up with an external pulling rope 5, the closable opening surface 21 on the cover body 2 is opened, and an anesthetic is injected into the abdominal cavity of the mouse;

[0061] Open the cover 3, disassemble the cover body 2 and the plastic arc-shaped frame 11, change the position of the mouse so that the head of the mouse is close to one end of the cover 3 and the mouse lies on its back, and use the external pulling rope 5 on the first bottom plate 7 to fix the limbs of the mouse;

[0062] Half-close the lid 3 to lift the mouse's head and perform surgery on the mouse's oral cavity.

[0063] The method for using the mouse experiment device of the embodiment of the present invention can adapt to the structural changes in different steps during use, has various functions, and only one such device is needed from beginning to end to basically complete the entire operation process.

[0064] Optionally, when the tightening cover 4 is tightened, a small hole is left in front of the tightening cover 4 so that the mouse can breathe smoothly.

[0065] Of course, the embodiments of the present invention are about mice, but can also be applied to rats. The size of the device can be adjusted according to actual conditions.

[0066] The various embodiments in this specification are described in a progressive manner, and the same or similar parts between the various embodiments can be referenced to each other. Each embodiment focuses on the differences from other embodiments.

[0067] The above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit the present application. Although the present application has been described in detail with reference to the aforementioned embodiments, a person of ordinary skill in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some or all of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the present application.

Claims

1. A device for mouse experiments, characterized in that: It comprises a first bottom plate (7), a frame (1), a plastic metal wire (6), a cover body (2), a cover surface (3) and a tightening cover (4); The frame (1) is an arc-shaped structure as a whole, and comprises a first bottom plate (7), arc-shaped curved sections (12) at both ends of the first bottom plate (7), and a plastic arc-shaped frame (11), and the two ends of the arc-shaped curved sections (12) and the two ends of the plastic arc-shaped frame (11) are connected by mortise and tenon joints; The plurality of plastic metal wires (6) are bent as a whole to have the same curvature as the plastic arc-shaped frame (11); the plurality of plastic metal wires (6) and at least two plastic arc-shaped frames (11) are arranged transversely; and the plastic arc-shaped frames (11) and the plurality of plastic metal wires (6) are located inside the cover body (2); A plurality of connection rings for connecting the plastic metal wire (6) are provided on both sides of the first bottom plate (7); both ends of the plastic metal wire (6) are hook-shaped structures, and the hook-shaped structures are hooked on the connection rings; the plastic metal wire (6) is movably connected inside the cover body (2) and can be pulled out inside the cover body (2); a plurality of external pulling ropes (5) are provided on both sides of the first bottom plate (7) near the hook-shaped structures of the plastic metal wire (6); The cover body (2), the plurality of the plastic arc-shaped frames (11), the arc-shaped curved sections (12) of the plurality of the plastic metal wires (6) and the first bottom plate (7) form a tunnel structure, one end of the tunnel structure being a cover surface (3) and the other end being a tightening cover (4), the cover surface (3) being hingedly connected to the frame (1) of the tunnel structure; a closable opening surface (21) is provided at the upper portion of one end of the cover body (2) close to the cover surface (3); A second bottom plate (8) is provided at the bottom of the first bottom plate (7), a supporting leg is provided at the bottom of the second bottom plate (8), and the area of ​​the second bottom plate (8) is larger than the area of ​​the first bottom plate (7); A protruding structure is provided at the bottom of the first bottom plate (7), and a groove is provided at a corresponding position of the second bottom plate (8), wherein the protruding structure is locked in the groove; It also comprises a clamping mechanism (10), the clamping mechanism (10) being an inverted "F"-shaped structure as a whole, and the inverted "F"-shaped structure comprising a vertical support rod (101) and an integrated clamping portion (102), the clamping portion (102) being used to clamp the first bottom plate (7), and when in use, the clamping portion (102) is located at a side position of the mouse's oral cavity on the first bottom plate (7); The vertical support rod (101) is provided with lighting lamps (16) and three-arm structures at different heights, the lighting lamp (16) being located at a height higher than the three-arm structure, and the lighting lamp (16) and the three-arm structure are connected on the vertical support rod (101) via a cross clamp (13) that is movable in multiple directions; The three-arm structure comprises a movable connecting end (14), an upper arm (121), a lower arm (122) and an intermediate arm (123); one end of the upper arm (121), the lower arm (122) and the intermediate arm (123) are all connected to the movable connecting end (14) in different directions, and one end of the upper arm (121), the lower arm (122) and the intermediate arm (123) away from the movable connecting end (14) is a free end; the movable connecting end (14) is connected to the vertical support rod (101) via a connecting rod and the cross clamp (13); The upper arm (121) and the lower arm (122) have the same and symmetrical structures, and the length of the middle arm (123) is shorter than the lengths of the upper arm (121) and the lower arm (122).

2. The mouse experiment device according to claim 1, characterized in that: One end of the tightening cover (4) is connected to the plastic arc-shaped frame (11), and an internal pulling rope is provided inside the tightening cover (4).

3. The mouse experiment device according to claim 1, characterized in that: A square block (9) is provided on one end of the first bottom plate (7) close to the cover surface (3); the square block (9) is slidably connected to the first bottom plate (7), and the square block (9) slides on the first bottom plate (7) in the transverse direction of the first bottom plate (7).

4. The mouse experiment device according to claim 1, characterized in that: The three-arm structure comprises a movable connecting end (14), an upper arm (121), a lower arm (122) and an intermediate arm (123); one end of the upper arm (121), the lower arm (122) and the intermediate arm (123) are all connected to the movable connecting end (14) in different directions, and one end of the upper arm (121), the lower arm (122) and the intermediate arm (123) away from the movable connecting end (14) is a free end; the movable connecting end (14) is connected to the vertical support rod (101) via a connecting rod and the cross clamp (13); The upper arm (121) and the lower arm (122) have the same and symmetrical structures, and the length of the middle arm (123) is shorter than the lengths of the upper arm (121) and the lower arm (122).

5. The mouse experiment device according to claim 4, characterized in that: The overall structure of the upper arm (121) is that it starts from the movable connection end (14) and moves away from the middle arm (123), then moves closer to the middle arm (123), and finally moves away from the middle arm (123); The upper arm (121) comprises a first curved section and a second curved section, the first curved section and the second curved section are integrated and continuous, and the first curved section and the second curved section have opposite bending directions; the lower arm (122) and the upper arm (121) have the same structure and are symmetrically arranged on both sides of the middle arm (123); the middle arm (123) is straight as a whole, and a free end of the middle arm (123) is provided with an arc-shaped hook.

6. The mouse experiment device according to claim 4, characterized in that: The movable connection end (14) is a wire loop in different directions, and the length and direction of the wire loop are adjustable.

7. A method for using a device for mouse experiments, characterized in that: Using the mouse experiment device according to claim 1 comprises the following steps: Opening the cover surface (3) of the tunnel structure and tightening the tightening cover (4) so ​​that the mouse can drill into the tunnel structure; Closing the cover (3), straightening the free end connection of the plastic metal wire (6), and pulling out the plastic metal wire (6), thereby removing the plastic metal wire (6); The mouse is tied up with the external pulling rope (5), the closable opening surface (21) on the cover (2) is opened, and an anesthetic is injected into the abdominal cavity of the mouse; The cover (3) is opened, and the cover body (2) and the plastic arc-shaped frame (11) are disassembled, and the position of the mouse is changed so that the head of the mouse is close to one end of the cover (3) and the mouse lies on its back, and the limbs of the mouse are fixed by using the external pulling rope (5) on the first bottom plate (7); The cover (3) is half-closed to lift the head of the mouse, and surgery is performed on the oral cavity of the mouse.

8. The method for using the mouse experiment device according to claim 7, characterized in that: When the tightening cover (4) is tightened, a small hole is left in front of the tightening cover (4).

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