An antibacterial lotion for treating tinea pedis and its preparation method

Abstract

The present invention discloses an antibacterial lotion for treating tinea pedis and a preparation method thereof. The lotion is made from natural phenols with small molecular weight, medium molecular weight, large molecular weight and a water-soluble polymer adjuvant. Preferably, they are eugenol, pine bark extract, tannic acid and poloxamer. The mass of each component is 2-10 parts of eugenol, 5-10 parts of pine bark extract, 5-10 parts of tannic acid, 1-5 parts of poloxamer, and 1-5 parts of water. Tannic acid in the present invention has astringency and bactericidal properties, eugenol has bactericidal properties, and pine bark extract has antibacterial properties. When the three are used in combination, they can effectively treat tinea pedis and reduce the peeling phenomenon after application.

Description

Technical Field

[0001] The present invention relates to an emulsion made of phenols with different molecular weights, and specifically to an antibacterial cream for treating tinea pedis and its preparation method. It belongs to the technical field of treating skin diseases. Background Art

[0002] Tinea pedis (commonly known as athlete's foot) is caused by fungal infection. Clinically, it is commonly caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton floccosum, Trichophyton roseum, etc. Sometimes, Candida infection or other yeast infections may also occur. Its skin lesions often occur unilaterally (i.e., on one foot) first and infect the opposite side after several weeks or months. Blisters mainly appear on the toe pulp and the side of the toes, most commonly between the third and fourth toes, and can also appear on the sole of the foot. They are deep-seated small blisters that can gradually merge into large blisters. The skin lesions of tinea pedis have a characteristic, that is, the boundary is clear and can gradually expand outward. Due to the development of the disease or scratching, erosion, exudation, or even bacterial infection may occur, resulting in pustules, etc.

[0003] Phenolic derivatives are compounds containing phenols, which is a large and complex family of compounds. Due to the high reactivity of their hydroxyl substitutions and their ability to scavenge free radicals, these compounds have the potential for antioxidant activity. Phenolic compounds can be divided into small molecular weight, medium molecular weight, and large molecular weight. Among them, small molecular weight natural phenols include guaiacol, eugenol, etc. Among them, eugenol has an inhibitory effect on pathogenic fungi at a concentration of 1:8000 - 1:16000, and has a strong bactericidal power, and also has a local antiseptic effect.

[0004] Medium molecular weight natural phenols include pine bark extract, grape seed extract, etc. Among them, pine bark extract is an oligomer of anthocyanins, which can accelerate wound healing and has a bactericidal effect. It can inhibit the inflammatory response and promote recovery.

[0005] Large molecular weight natural phenols are represented by tannic acid. Tannic acid is an astringent, which can precipitate proteins and form insoluble complexes with alkaloids, glycosides, heavy metals, etc. It is mainly used locally. Its 11% - 20% ointment is used for exudative ulcers, burns, bedsores, hemorrhoids, eczema, etc. Its 15% - 20% glycerol solution is used for stomatitis, tonsillitis, pharyngitis, etc., and is also used for detoxification.

[0006] Tannic acid belongs to plant polyphenols, is a natural polymer, has the effect of astringing muscle tissue and has a bactericidal effect. Eugenol belongs to small molecular weight phenolic compounds, which can cause skin ulcers but has a bactericidal effect. Pine bark extract belongs to medium molecular weight phenolic compounds, which can effectively inhibit inflammation. The mixed use of small molecular weight, medium molecular weight, and large molecular weight phenolic compounds can effectively treat tinea pedis and reduce the peeling phenomenon after application. Summary of the Invention

[0007] The object of the present invention is to provide an antibacterial lotion for treating tinea pedis and a preparation method thereof. To achieve the above object, the present invention adopts the following technical solutions:

[0008] The antibacterial lotion for treating tinea pedis, the weight parts of its various components are: eugenol 2 - 10 parts, pine bark extract 5 - 10 parts, tannic acid 5 - 10 parts, poloxamer 407 1 - 5 parts, water 10 - 500 parts.

[0009] The production method has the following steps:

[0010] Weigh a quantitative amount of tannic acid and dissolve it in water. Then add poloxamer 407 to the pine bark extract and eugenol, add an appropriate amount of water and heat, and stir evenly; finally, mix with tannic acid to obtain the lotion.

[0011] The advantages and beneficial effects of the present invention are: The lotion prepared by the present invention can effectively treat the occurrence of tinea pedis, and the tannic acid therein can precipitate proteins, has astringent effects, can harden the skin, and thus protect the mucosa. Eugenol has an inhibitory effect on pathogenic fungi, and the pine bark extract has antibacterial properties. The combined use of the three can significantly improve the curative effect and reduce the peeling phenomenon after applying the lotion. Applying it twice a day can effectively treat tinea pedis. Specific embodiments

[0012] The following further describes the products of the present invention in combination with the embodiments of the present invention. The description of the embodiments is only for facilitating the understanding and application of the present invention, rather than a limitation on the protection of the present invention. Unless otherwise specified, the preparation process is carried out under normal temperature and normal pressure; unless otherwise specified, the reagents, methods, and equipment used in the present invention are conventional reagents, methods, and equipment in the technical field; unless otherwise specified, the test conditions adopted in the present invention are conventional test conditions in the technical field; unless otherwise specified, the reagents used in the present invention are all commercially available.

[0013] Example 1

[0014] Tannic acid 3 parts, pine bark extract 3 parts, eugenol 3 parts, poloxamer 407 3 parts, water 100 parts.

[0015] Weigh a quantitative amount of tannic acid and dissolve it in water. Then add poloxamer 407 to the pine bark extract and eugenol, add an appropriate amount of water and heat and stir; finally, mix with tannic acid to obtain the lotion.

[0016] The prepared lotion was used on 20 patients, and after several months, observations and tests were carried out.

[0017] The specific details of other examples are shown in Table 1. Except for the different formulations, the preparation processes are the same as those in Example 1.

[0018] Comparative Example 1

[0019] 4 parts of eugenol, 5 parts of pine bark extract, 3 parts of poloxamer 407, and 80 parts of water.

[0020] Weigh a quantitative amount of eugenol and pine bark extract. After mixing them evenly, add poloxamer 407, and then add an appropriate amount of water and heat with stirring to obtain an emulsion.

[0021] Apply the prepared emulsion to 20 patients and observe and conduct tests after several months.

[0022] The specific other comparative examples are shown in Table 1. The preparation processes are the same as those of Comparative Example 1 except for the different formulations.

[0023] Table 1 Ingredients of Each Example and Comparative Example

[0024]

[0025]

[0026] The present invention has a total of 10 examples. 20 patients with tinea pedis are selected in each group, with half male and half female, and the average age is 35 years. After applying for several months, fungal tests are conducted on the patients. The testing steps are as follows:

[0027] (1) Scrape the skin at the edge of the lesion area, place the collected specimen on a glass slide, add 1 drop of 10% potassium hydroxide solution, and cover with a cover glass;

[0028] (2) Warm slightly, avoid boiling, expel the blisters, gently press and thin it into a cloudy shape, and suck out the overflow liquid;

[0029] (3) Observe whether there are yeast-like spores and fungal hyphae in the specimen smear under a microscope.

[0030] Table 2 Fungal Test Results of Each Example and Comparative Example

[0031]

[0032] As described in Tables 1 and 2, it shows that phenols with small molecular weight, medium molecular weight, and large molecular weight have a synergistic effect, and the effect of treating tinea pedis is obvious. They are all essential components of the present invention; moreover, the combined use of eugenol, pine bark extract, and tannic acid has the best effect.

[0033] The above is only the application implementation mode of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. An antibacterial lotion for treating tinea pedis, characterized in that, Composed of the following substances: small molecule eugenol, medium molecule pine bark extract, large molecule tannic acid, water-soluble polymer; the water-soluble polymer is polyvinylpyrrolidone k30 or polyethylene glycol 400 or poloxamer 407; The mass ratio of the small molecule eugenol, medium molecule pine bark extract, and large molecule tannic acid is 1-2:1-2:1-2; The steps for preparing the antibacterial emulsion are as follows: Weigh a certain amount of tannic acid and dissolve it in water; then add poloxamer 407, or polyvinylpyrrolidone k30, or polyethylene glycol 400 to the pine bark extract and eugenol, add an appropriate amount of water and heat, and stir evenly; finally, mix with tannic acid to obtain the emulsion.

2. The antibacterial lotion for treating tinea pedis according to claim 1, wherein, The composition of the emulsion is: 1 part by total mass of phenols, 0.1-3 parts by mass of water-soluble polymer, and 10-1000 parts by mass of water.

3. An antibacterial lotion for treating tinea pedis according to claim 1, characterized in that, The water-soluble polymer is poloxamer 407.

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