A kind of blue light blocking organic contact lens and preparation method

Abstract

The invention discloses an organic contact lens for preventing blue light and a preparation method thereof. The lens comprises a lens made of silk fibroin as a raw material; the lens is a reaction product of silicon dioxide nanoparticles, acrylamide and silk fibroin; then it is soaked in a hydrofluoric acid solution; the silicon dioxide nanoparticle solution, the acrylamide solution and the silk fibroin solution are mixed and then dripped into a contact lens mold, and air-dried to obtain the lens; then the lens is soaked in a hydrofluoric acid solution; the technical problems such as the scarcity of blue light prevention processing technology for contact lenses, the high cost of existing technology, the increased production and processing cost of contact lenses and the difficulty of promotion in the market are solved.

Description

Technical Field

[0001] The invention belongs to the technical field of contact lenses, and in particular relates to a blue light blocking organic contact lens and a preparation method thereof. Background Art

[0002] With the development of science, contact lenses have attracted more and more consumers with their convenience and aesthetics. However, the basic material of contact lenses is still mainly polymer hydrogel, which means that while contact lenses have not overcome the risk of microplastics posing a threat to the environment, they also have poor air permeability and oxygen permeability, poor biocompatibility, and increase the risk of corneal hypoxia, causing redness, swelling, and pain in the eyes. In addition, with the popularization of electronic products, protection against blue light radiation has gradually become an urgent need for consumers. However, the anti-blue light processing technology for contact lenses on the market is still very scarce, and the existing technology costs are high, which increases the production and processing costs of contact lenses and the difficulty of promotion in the market. Summary of the invention

[0003] The technical problem to be solved by the present invention is: to provide a blue light blocking organic contact lens and a preparation method, so as to solve the technical problems that the blue light blocking processing technology used in contact lenses is still very scarce, the existing technology costs are high, which increases the production and processing costs of contact lenses and the difficulty of promotion in the market.

[0004] The technical solution of the present invention is:

[0005] A blue light protection organic contact lens, the lens having a lens made of silk fibroin as a raw material; the lens is a reaction product of silicon dioxide nanoparticles, acrylamide and silk fibroin; and then soaked in a hydrofluoric acid solution.

[0006] A method for preparing a blue light-proof organic contact lens comprises the steps of uniformly mixing a silicon dioxide nanoparticle solution, an acrylamide solution and a silk fibroin solution, dripping the mixture into a contact lens mold, and air-drying the mixture to obtain a lens; and then soaking the lens in a hydrofluoric acid solution.

[0007] The concentration of the silica nanoparticle solution is 0.1%~10% (g / mL), the concentration of the acrylamide solution is 0.01%~1% (g / mL), and the concentration of the silk fibroin solution is 1%~20% (g / mL); the silica nanoparticle solution, acrylamide solution and silk fibroin solution are mixed in a volume ratio of 1:1:10.

[0008] The particle size of silica nanoparticles is 1~20 nm.

[0009] The silica nanoparticle solution, acrylamide solution and silk fibroin solution are mixed and then dropped into a contact lens mold, and then placed in an environment with a temperature of 25-45°C and a humidity of 10%-50% for air drying; the air-dried lens is sequentially immersed in a hydrofluoric acid solution with a mass fraction of 1-10% and in sterile ultrapure water for 20-120 minutes each; the lens is washed with sterile ultrapure water to obtain a blue light blocking organic lens.

[0010] The glasses include silk fibroin lenses and optical holes left in the lenses after being soaked in hydrofluoric acid; the silk fibroin lenses are porous silk fibroin films doubly induced by acrylamide molecules and silica nanoparticles, and the preparation method is: silica nanoparticles and acrylamide molecules are mixed with silk fibroin solution to induce amorphous silk fibroin to form a crystalline and stable porous silk fibroin film, and then the acrylamide is removed by repeated soaking and rinsing.

[0011] The beneficial effects of the present invention are:

[0012] The main ingredients and functions of the blue light blocking organic contact lenses provided by the present invention are as follows:

[0013] Silk fibroin: An excellent natural polymer fibrous protein that has been widely used in the field of biomedical materials. As a natural biomaterial, silk fibroin has many remarkable excellent properties, such as good biocompatibility, suitable mechanical properties, low immunity and controllable degradation rate. In addition, silk fibroin can achieve a multi-scale structure from water-soluble to water-insoluble during the forming process. At present, silk fibroin scaffolds have been widely used in a variety of tissue engineering, including the repair of cartilage, nerves, blood vessels, etc. In addition, its reliable source and easy access are also a major advantage of its wide application.

[0014] Acrylamide: used as raw material for organic synthesis and raw material for polymer materials. Usually soluble in water, especially has a good effect on the flocculation of protein and starch in water. It has excellent properties such as flocculation, thickening, shear resistance, drag reduction, and dispersibility.

[0015] Silica nanoparticles: a type of inorganic compound nanoparticles with an inert surface, which can be doped into polymers as a template, and then dissolved by soaking in hydrofluoric acid, forming micropores inside the polymer. The present invention applies this effect to contact lenses, greatly improving the oxygen permeability of the lenses.

[0016] In summary, the blue light blocking organic contact lenses provided by the present invention have at least the following beneficial effects:

[0017] High security:The silk protein used to make the lenses comes from nature, has good biocompatibility and is safe for the human body. The porous structure of the lenses makes them highly oxygen permeable, which can prevent eye redness and pain caused by corneal hypoxia and protect the wearer's eye health.

[0018] Versatile The blue light-proof organic contact lens of the present invention can stimulate Rayleigh scattering by manufacturing optical holes of specific sizes, resist blue light, and prevent vision loss caused by radiation from electronic products.

[0019] Environmental friendly :The silk protein that makes up the lens can be degraded in the natural environment and does not pollute the environment.

[0020] It solves the technical problems that the anti-blue light processing technology for contact lenses is still very scarce, the existing technology is expensive, which increases the production and processing costs of contact lenses and the difficulty of promoting them in the market. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a flow chart of the preparation of blue light blocking organic contact lenses in one embodiment of the present invention;

[0022] Figure 2 1 is a schematic diagram of a longitudinal section of a blue light blocking organic contact lens in one embodiment of the present invention. DETAILED DESCRIPTION

[0023] like Figure 1 As shown, the preparation process of the present invention includes the following main steps: mixing a silica nanoparticle solution, an acrylamide reagent and a silk fibroin solution; dropping the mixed solution into a contact lens mold, air-drying and shaping; and soaking in a hydrofluoric acid solution.

[0024] The present invention uses silicon dioxide nanoparticles, acrylamide and silk fibroin to prepare a porous silk fibroin film, thereby obtaining a blue light-proof contact lens with high safety, good oxygen permeability and green environmental protection.

[0025] The invention provides a blue light protection organic contact lens, which has a lens with silk fibroin as a main raw material; the lens is a reaction product of silicon dioxide nanoparticles, acrylamide and silk fibroin; and then is soaked in a hydrofluoric acid solution.

[0026] The lens preparation method comprises: mixing a silicon dioxide nanoparticle solution, an acrylamide solution and a silk fibroin solution, dripping the mixture into a contact lens mold, and air-drying the mixture to obtain the lens.

[0027] The concentration of the silica nanoparticle solution is 0.1%~10% (g / mL), the concentration of the acrylamide solution is 0.01%~1% (g / mL), and the concentration of the silk fibroin solution is 1%~20% (g / mL); the silica nanoparticle solution, the acrylamide solution and the silk fibroin solution are mixed in a volume ratio of 1:1:10.

[0028] The particle size of the silicon dioxide nanoparticles is 1-20 nm.

[0029] Mix the silica nanoparticle solution, acrylamide solution and silk fibroin solution and drip them into the contact lens mold, and place them in an environment with a temperature of 25-45°C and a humidity of 10%-50% for air drying. Soak the air-dried lenses in a hydrofluoric acid solution with a mass fraction of 1-10% and sterile ultrapure water for 20-120 minutes respectively; wash the lenses with sterile ultrapure water to obtain blue light-proof organic lenses;

[0030] The invention mixes a silicon dioxide nanoparticle solution, an acrylamide solution and a silk fibroin solution, drips the mixture into a contact lens mold, and air-dries the mixture to obtain a lens; and then soaks the lens in a hydrofluoric acid solution.

[0031] The blue light-proof organic contact lens provided by the present invention comprises a silk fibroin lens and an optical hole left in the lens after being soaked in hydrofluoric acid. The silk fibroin lens is a porous silk fibroin membrane doubly induced by acrylamide molecules and silica nanoparticles, and the preparation method thereof is as follows: silica nanoparticles and acrylamide molecules are mixed with a silk fibroin solution to induce amorphous silk fibroin to form a crystalline and stable porous silk fibroin membrane, and then acrylamide is removed by repeated soaking and rinsing. The porous structure of the silk fibroin lens gives the contact lens the functions of blue light resistance and high oxygen permeability.

[0032] In the reaction of acrylamide molecules inducing silk fibroin film formation, the silk fibroin concentration is 1% to 20%, the acrylamide concentration is 0.01% to 1%, and the doping concentration of silica nanoparticles is 0.1% to 10%. The particle size of the silica nanoparticles is 1 to 20 nm. The temperature range of the acrylamide molecules inducing silk fibroin film formation is 25 to 45°C. In some embodiments, the humidity range of the acrylamide molecules inducing silk fibroin film formation is 10% to 50%.

[0033] Main reagents :

[0034] Silica nanoparticle solution was purchased from Nanjing Caina Biotechnology Co., Ltd., with a particle size of 1-20 nm, item number MS-50-101. Acrylamide was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd., item number A108465-100g. Silk fibroin was purchased from Suzhou Simet Biotechnology Co., Ltd., item number LPSXKOA001.

[0035] Solution preparation :

[0036] 1% (g / mL) silica nanoparticle solution: The concentration of the purchased silica nanoparticle solution is 5% (g / mL). When used, it is diluted five times to 1% (g / mL) with ultrapure water.

[0037] 0.2% (g / mL) acrylamide solution: Weigh 0.02 g of acrylamide solid particles and add them into 10 mL of ultrapure water to prepare a 0.2% (g / mL) acrylamide solution.

[0038] 4% (g / mL) silk fibroin solution: Weigh 2 g of silk fibroin solid particles and add them into 50 mL of ultrapure water to prepare a 4% (g / mL) silk fibroin solution.

[0039] 4% (w / w) hydrofluoric acid solution: The mass fraction of the purchased hydrofluoric acid solution is 40%. When used, it is diluted 10 times with ultrapure water to obtain a 4% (w / w) hydrofluoric acid solution.

[0040] If not otherwise specified, the reagents used in the following examples are all conventional reagents in the art, which can be obtained commercially or prepared according to conventional methods in the art, and the specifications are laboratory pure. If not otherwise specified, the experimental methods and conditions used in the following examples are all conventional experimental methods and conditions in the art, and reference can be made to relevant experimental manuals, known documents or manufacturer specifications. Unless otherwise defined, the meanings of all technical and scientific terms used herein are the same as those generally understood by those of ordinary skill in the art to which the present invention belongs.

[0041] Example 1. Preparation of blue light blocking silk fibroin contact lenses

[0042] 1. Preparation of porous silk fibroin lenses

[0043] Take 0.1 mL of 1% (g / mL) silica nanoparticle solution, 0.1 mL of 0.2% (g / mL) acrylamide solution and 1 mL of 4% (g / mL) silk fibroin solution, add them to a 5 ml centrifuge tube and mix them evenly. Take 100 μL of the mixed solution and drop it into the contact lens mold. Place it in a ventilated place at 25~45℃ to air dry to obtain a silk fibroin lens containing acrylamide molecules and silica nanoparticles.

[0044] 2. Fabrication of optical holes

[0045] Soak the lenses in 4% (w / w) hydrofluoric acid solution and sterile ultrapure water for 30 minutes respectively, then remove the soaking solution, add sterile ultrapure water to wash for 30 minutes, and finally put the cleaned lenses into sterile saline for storage.

Claims

1. A blue light blocking organic contact lens, characterized in that: The glasses have lenses made of silk fibroin as a raw material; the lenses are the reaction product of silicon dioxide nanoparticles, acrylamide and silk fibroin; then they are soaked in a hydrofluoric acid solution; the silicon dioxide nanoparticle solution, the acrylamide solution and the silk fibroin solution are mixed and then dripped into a contact lens mold, and air-dried to obtain the lenses; then the lenses are soaked in a hydrofluoric acid solution; the concentration of the silicon dioxide nanoparticle solution is 0.1% to 10% g / mL, the concentration of the acrylamide solution is 0.01% to 1% g / mL, the concentration of the silk fibroin solution is 1% to 20 % g / mL; the silica nanoparticle solution, acrylamide solution and silk fibroin solution are mixed in a volume ratio of 1:1:10; the silica nanoparticle solution, acrylamide solution and silk fibroin solution are mixed and then dropped into a contact lens mold, and placed in an environment with a temperature of 25-45°C and a humidity of 10%-50% for air drying; the air-dried lens is sequentially immersed in a hydrofluoric acid solution with a mass fraction of 1-10% and in sterile ultrapure water for 20-120 minutes each; the lens is washed with sterile ultrapure water to obtain a blue light-proof organic lens.

2. The method for preparing a blue light blocking organic contact lens according to claim 1, characterized in that: The particle size of silica nanoparticles is 1~20 nm.

3. The method for preparing a blue light blocking organic contact lens according to claim 1, characterized in that: The glasses include silk fibroin lenses and optical holes left in the lenses after being soaked in hydrofluoric acid; the silk fibroin lenses are porous silk fibroin films doubly induced by acrylamide molecules and silica nanoparticles, and the preparation method is: silica nanoparticles and acrylamide molecules are mixed with silk fibroin solution to induce amorphous silk fibroin to form a crystalline and stable porous silk fibroin film, and then the acrylamide is removed by repeated soaking and rinsing.

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