Blood glucose detection method, device and blood glucose detection equipment

Abstract

The present application is applicable to the field of electrochemical detection technology, and provides a blood glucose detection method, device, blood glucose detection equipment and computer-readable storage medium, the method comprising: when a blood sample to be tested contacts with a biological enzyme on a blood glucose test strip, at a first preset time point after a voltage is applied to a first pair of electrodes, by collecting a hematocrit background current value of the blood sample to be tested, and then at a second preset time point after a voltage is applied to a second pair of electrodes, collecting a blood glucose current value of the blood sample to be tested; and then determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and a compensation coefficient corresponding to the blood glucose test strip, thereby converting the blood glucose concentration according to the compensation coefficient corresponding to the blood glucose test strip, the hematocrit background current value and the blood glucose current value, thereby significantly reducing the interference of the hematocrit on the blood glucose test in the blood, and improving the accuracy of the blood glucose test result.

Description

Technical Field

[0001] The present application belongs to the field of electrochemical detection technology, and in particular, relates to a blood glucose detection method, device, blood glucose detection equipment and computer-readable storage medium. Background Art

[0002] Electrochemical methods were first used in biosensors to detect target substances in the blood, such as glucose. The reaction principle is that the blood to be tested comes into contact with the biological enzyme reagent fixed on the biosensor. Under the applied voltage, the active substance gains and loses electrons on the electrode surface. The gained and lost electrons are conducted along the electrode to generate current. The current is proportional to the concentration of the substance, so the detected current is converted into blood glucose concentration for display.

[0003] However, the current blood sugar detection method is easily interfered by the hematocrit in the blood during the test, which causes large errors in the blood sugar test results. Summary of the invention

[0004] The blood glucose detection method, device, blood glucose detection equipment and computer-readable storage medium provided in the embodiments of the present application can solve the problem that the blood glucose test results are easily interfered by the hematocrit in the blood during the test process, thereby causing large errors.

[0005] In a first aspect, an embodiment of the present application provides a blood sugar detection method, comprising:

[0006] When the blood sample to be tested contacts the biological enzyme on the blood glucose test strip, at a first preset time point after a voltage is applied to the first pair of electrodes, the hematocrit background current value of the blood sample to be tested is collected; at a second preset time point after a voltage is applied to the second pair of electrodes, the blood glucose current value of the blood sample to be tested is collected; and the blood glucose concentration of the blood sample to be tested is determined based on the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip.

[0007] In a second aspect, an embodiment of the present application provides a blood sugar detection device, comprising:

[0008] The first acquisition module is used to collect the hematocrit background current value of the blood sample to be tested at the first preset time point after the voltage is applied to the first pair of electrodes when the blood sample to be tested contacts the biological enzyme on the blood glucose test strip; the second acquisition module is used to collect the blood glucose current value of the blood sample to be tested at the second preset time point after the voltage is applied to the second pair of electrodes; the detection module is used to determine the blood glucose concentration of the blood sample to be tested based on the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip.

[0009] In a third aspect, an embodiment of the present application provides a blood glucose detection device, comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor implements the blood glucose detection method described in any one of the first aspects above when executing the computer program.

[0010] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the blood glucose detection method described in any one of the first aspects above is implemented.

[0011] In a fifth aspect, an embodiment of the present application provides a computer program product. When the computer program product runs on a blood glucose testing device, the blood glucose testing device executes the blood glucose testing method described in any one of the above-mentioned first aspects.

[0012] It can be understood that the beneficial effects of the second to fifth aspects mentioned above can be found in the relevant description of the first aspect mentioned above, and will not be repeated here.

[0013] Compared with the prior art, the embodiments of the present application have the following beneficial effects: when the blood sample to be tested contacts the biological enzyme on the blood glucose test strip, at a first preset time point after a voltage is applied to the first pair of electrodes, the hematocrit background current value of the blood sample to be tested is collected, and then at a second preset time point after a voltage is applied to the second pair of electrodes, the blood glucose current value of the blood sample to be tested is collected, and then the blood glucose concentration of the blood sample to be tested is determined based on the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip. Thus, by converting the blood glucose concentration based on the compensation coefficient corresponding to the blood glucose test strip, the hematocrit background current value and the blood glucose current value, the interference of the hematocrit on the blood glucose test in the blood is significantly reduced, thereby improving the accuracy of the blood glucose test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0015] Figure 1 It is a flow chart of a blood sugar detection method provided in one embodiment of the present application;

[0016] Figure 2 is a flow chart of a blood glucose detection method provided in another embodiment of the present application;

[0017] Figure 3is a structural schematic diagram of a blood sugar detection device provided in one embodiment of the present application;

[0018] Figure 4 It is a structural schematic diagram of a blood glucose detection device provided in one embodiment of the present application. DETAILED DESCRIPTION

[0019] In the following description, specific details such as specific system structures, technologies, etc. are provided for the purpose of illustration rather than limitation, so as to provide a thorough understanding of the embodiments of the present application. However, it should be clear to those skilled in the art that the present application may also be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, devices, circuits, and methods are omitted to prevent unnecessary details from obstructing the description of the present application.

[0020] It should be understood that when used in the present specification and the appended claims, the term "comprising" indicates the presence of described features, wholes, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, wholes, steps, operations, elements, components and / or combinations thereof.

[0021] It should also be understood that the term “and / or” used in the specification and appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0022] As used in the specification and appended claims of this application, the term "if" can be interpreted as "when" or "uponce" or "in response to determining" or "in response to detecting", depending on the context. Similarly, the phrase "if it is determined" or "if [described condition or event] is detected" can be interpreted as meaning "uponce it is determined" or "in response to determining" or "uponce [described condition or event] is detected" or "in response to detecting [described condition or event]", depending on the context.

[0023] In addition, in the description of the present application specification and the appended claims, the terms "first", "second", "third", etc. are only used to distinguish the descriptions and cannot be understood as indicating or implying relative importance.

[0024] References to "one embodiment" or "some embodiments" etc. described in the specification of this application mean that one or more embodiments of the present application include specific features, structures or characteristics described in conjunction with the embodiment. Therefore, the statements "in one embodiment", "in some embodiments", "in some other embodiments", "in some other embodiments", etc. that appear in different places in this specification do not necessarily refer to the same embodiment, but mean "one or more but not all embodiments", unless otherwise specifically emphasized in other ways. The terms "including", "comprising", "having" and their variations all mean "including but not limited to", unless otherwise specifically emphasized in other ways.

[0025] It should be understood that the size of the serial numbers of the steps in this embodiment does not mean the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiment of the present application.

[0026] The blood sugar detection method in the related art is easily interfered by the hematocrit in the blood during the test, thus causing large errors in the blood sugar test results.

[0027] The present application provides a blood glucose detection method, in which a blood sample to be tested contacts with a biological enzyme on a blood glucose test strip, at a first preset time point after a voltage is applied to a first pair of electrodes, a hematocrit background current value of the blood sample to be tested is collected, and then at a second preset time point after a voltage is applied to a second pair of electrodes, a blood glucose current value of the blood sample to be tested is collected; and then, based on the hematocrit background current value, the blood glucose current value and a compensation coefficient corresponding to the blood glucose test strip, the blood glucose concentration of the blood sample to be tested is determined, thereby, by converting the blood glucose concentration based on the compensation coefficient corresponding to the blood glucose test strip, the hematocrit background current value and the blood glucose current value, the interference of the hematocrit on the blood glucose test is significantly reduced, thereby improving the accuracy of the blood glucose test result.

[0028] The blood sugar detection method provided by the present application can be executed by a blood sugar detection device. In order to illustrate the technical solution of the present application, the method takes the blood sugar detection device as an example to illustrate the implementation process of the blood sugar detection method provided by the embodiment of the present application.

[0029] In one embodiment, referring to Figure 1 , a blood glucose detection method is provided, as an example and not as a limitation, such as Figure 1 As shown, the blood sugar detection method may include the following steps:

[0030] Step 101, when the blood sample to be tested contacts the biological enzyme on the blood glucose test strip and a voltage is applied to the first pair of electrodes, the hematocrit background current value of the blood sample to be tested is collected at a first preset time point.

[0031] The blood sample to be tested may be a blood sample that currently needs to undergo blood sugar testing.

[0032] The blood glucose test strip may be a blood glucose test strip coated with a biological enzyme and used in conjunction with a blood glucose testing device. The blood glucose test strip is coated with an ultra-thin conductive layer. As an example, the conductive layer of the blood glucose test strip includes a counter electrode, a power-on electrode, a full blood detection electrode, a hematocrit (Red blood cell specific volume, HCT) working electrode, and a blood glucose working electrode.

[0033] In a possible implementation of the embodiment of the present application, a blood glucose test strip is inserted into a test strip socket of a blood glucose testing device, the counter electrode and the power-on electrode are in a short-circuit state, and the blood glucose testing device is turned on and is in a standby state. The blood sample to be tested is placed in the reaction area of ​​the blood glucose test strip. When the reaction area of ​​the blood glucose test strip is full of blood, a passage is formed between the counter electrode and the full blood detection electrode. At this time, the blood glucose testing device starts timing, and at the same time, the blood sample to be tested contacts the biological enzyme on the blood glucose test strip. After a first preset time interval, a voltage is applied to the first pair of electrodes and timing is performed, that is, a voltage is applied between the counter electrode and the HCT working electrode. At this time, an electrochemical reaction occurs in the reaction area of ​​the blood glucose test strip. From the start of timing to the first preset time point, the current is collected to generate a current value, which is the hematocrit background current value of the blood sample to be tested.

[0034] Among them, the first preset time point can be a time point after the voltage is applied to the first pair of electrodes. The first preset time point can be determined according to the time when the electrochemical reaction fully occurs in the reaction area of ​​the blood glucose test paper. The first preset time point can be set to 1 second, 2 seconds, 3 seconds or 4 seconds after the voltage is applied to the first pair of electrodes, etc., and the embodiments of the present application do not limit this. In one example, the hematocrit background current value of the blood sample to be tested is collected at 5 seconds after the voltage is applied to the first pair of electrodes, and the first preset time point is 5 seconds after the voltage is applied to the first pair of electrodes.

[0035] The first preset time interval may be the time interval between the formation of a path between the pair of electrodes and the full blood detection electrode and the start of applying voltage to the first pair of electrodes. The first preset time interval may be determined based on the actual reaction time between the blood sample to be tested and the biological enzyme on the blood glucose test strip, such as an interval of 1 second, 2 seconds or 3 seconds.

[0036] It should be understood that after the first preset time interval, the first pair of electrodes is started and timing is started, so that the blood sample to be tested can fully react with the biological enzyme on the blood glucose test strip, which can improve the accuracy of collecting the hematocrit background current value.

[0037] It should be understood that the first pair of electrodes may be a pair of electrodes consisting of a counter electrode and a HCT working electrode.

[0038] Step 102, collecting the blood glucose current value of the blood sample to be tested at a second preset time point after the voltage is applied to the second pair of electrodes.

[0039] Among them, the second preset time point can be a time point after the application of voltage to the second pair of electrodes begins. The second preset time point can be determined according to the time for the electrochemical reaction to fully occur in the reaction area of ​​the blood glucose test strip. The second preset time point can be set to 1 second, 2 seconds, 3 seconds or 4 seconds after the application of voltage to the second pair of electrodes begins, etc., and the embodiments of the present application do not limit this. In one example, the blood glucose current value of the blood sample to be tested is collected at the 5th second after the application of voltage to the second pair of electrodes begins, and the second preset time point is the 5th second after the application of voltage to the second pair of electrodes begins.

[0040] The second pair of electrodes may be a pair of electrodes consisting of a counter electrode on a blood glucose test strip and a blood glucose working electrode.

[0041] In a possible implementation of the embodiment of the present application, a blood glucose test strip is inserted into a test strip socket of a blood glucose testing device, the counter electrode and the power-on electrode are in a short-circuit state, and the blood glucose testing device is turned on and is in a standby state. A blood sample to be tested is placed in the reaction area of ​​the blood glucose test strip. When the reaction area of ​​the blood glucose test strip is full of blood, a passage is formed between the counter electrode and the full blood detection electrode. At this time, the blood glucose testing device starts timing, and at the same time, the blood sample to be tested contacts the biological enzyme on the blood glucose test strip. After a first preset time interval, a voltage is applied to the first pair of electrodes and timing is performed, that is, a voltage is applied between the counter electrode and the HCT working electrode. At this time, An electrochemical reaction occurs in the reaction area of ​​the blood glucose test strip, and from the start of timing to the first preset time point, the current is collected to generate a current value, which is the hematocrit background current value of the blood sample to be tested. After a second preset time interval, the voltage applied between the counter electrode and the HCT working electrode is stopped, and then a voltage is applied to the second pair of electrodes and timing is performed, that is, a voltage is applied between the counter electrode and the blood glucose working electrode. At this time, an electrochemical reaction occurs in the reaction area of ​​the blood glucose test strip, and from the start of timing to the second preset time point, the current is collected to generate a current value, which is the blood glucose current value of the blood sample to be tested.

[0042] The second preset time interval may be determined according to actual blood glucose measurement accuracy, such as an interval of 1 second, 2 seconds or 3 seconds.

[0043] Step 103, determining the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip.

[0044] The compensation coefficient may be a calibration coefficient when calculating the blood glucose concentration of the blood sample to be tested. The compensation coefficients of blood glucose test strips from different production batches may be the same or different, and the compensation coefficients of blood glucose test strips from the same production batch may be the same.

[0045] It should be understood that blood glucose test strips from different production batches may, due to process problems, cause differences in the hematocrit background current value and blood glucose current value collected by the same blood glucose testing device. By testing blood glucose test strips from different production batches, compensation coefficients corresponding to each production batch of blood glucose test strips are generated. When a blood glucose testing device uses blood glucose test strips from a certain production batch to perform blood glucose testing, the compensation coefficient written in the blood glucose testing device corresponds to the compensation coefficient of the blood glucose test strips from that production batch.

[0046] As a possible implementation method, since the hematocrit of the blood will affect the blood glucose test results when performing blood glucose testing, in an embodiment of the present application, the compensation coefficient corresponding to the blood glucose test strip can be predetermined and stored in the blood glucose testing device. Then, when performing blood glucose monitoring, the compensation system corresponding to the blood glucose test strip can be used to correct the hematocrit background current value and the blood glucose current value to reduce the impact of the hematocrit of the blood on the blood glucose test results and improve the accuracy of blood glucose testing.

[0047] The blood glucose detection method provided in the embodiment of the present application brings the blood sample to be tested into contact with the biological enzyme on the blood glucose test strip, collects the hematocrit background current value of the blood sample to be tested at a first preset time point after applying voltage to the first pair of electrodes, and then collects the blood glucose current value of the blood sample to be tested at a second preset time point after applying voltage to the second pair of electrodes; and then determines the blood glucose concentration of the blood sample to be tested based on the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip, thereby converting the blood glucose concentration based on the compensation coefficient corresponding to the blood glucose test strip, the hematocrit background current value and the blood glucose current value, thereby significantly reducing the interference of the hematocrit on the blood glucose test in the blood, and improving the accuracy of the blood glucose test result.

[0048] In one embodiment, referring to Figure 2 , another blood sugar detection method is also provided, wherein the compensation coefficient corresponding to the blood sugar test strip includes: a hematocrit compensation coefficient and a blood sugar concentration compensation coefficient. Figure 2 , is a flow chart of another blood glucose detection method provided in an embodiment of the present application, comprising:

[0049] Step 301, when the blood sample to be tested contacts the biological enzyme on the blood glucose test strip and a voltage is applied to the first pair of electrodes, the hematocrit background current value of the blood sample to be tested is collected at a first preset time point.

[0050] Step 302, collecting the blood glucose current value of the blood sample to be tested at a second preset time point after the voltage is applied to the second pair of electrodes.

[0051] The specific implementation process and principle of the above steps 301 and 302 can be referred to the detailed description of the above embodiment, which will not be repeated here.

[0052] Step 303, determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient.

[0053] The compensated hematocrit value may be a hematocrit value calibrated by a hematocrit compensation coefficient.

[0054] The hematocrit compensation coefficient may be a coefficient related to hematocrit in blood glucose detection, and may include a first hematocrit compensation coefficient, a second hematocrit compensation coefficient, a third hematocrit compensation coefficient, and a fourth hematocrit compensation coefficient.

[0055] As a possible implementation, the hematocrit background current value and the blood glucose current value may be input into the hematocrit compensation function, and the compensated hematocrit value may be output. That is, the above step 303 may include:

[0056] The hematocrit background current value and the blood glucose current value are input into the hematocrit compensation function, and the compensated hematocrit value is output, wherein the hematocrit compensation function is:

[0057]

[0058] Among them, HCT comp is the hematocrit value after compensation, I HCT is the background current value of hematocrit, I w is the blood glucose current value, K1 is the first hematocrit compensation coefficient, B1 is the second hematocrit compensation coefficient, K2 is the third hematocrit compensation coefficient, and B2 is the fourth hematocrit compensation coefficient.

[0059] As a possible implementation manner, the first hematocrit compensation coefficient, the second hematocrit compensation coefficient, the third hematocrit compensation coefficient and the fourth hematocrit compensation coefficient may be determined in the following manner:

[0060] Prepare n×m blood glucose test samples with n kinds of blood glucose concentrations and m kinds of hematocrit combinations in advance; obtain the true blood glucose concentration values, hematocrit background current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples, wherein the hematocrit background current test values ​​can be obtained by testing the n×m blood glucose test samples with blood glucose test strips from the same batch as the blood glucose test strips; determine the first hematocrit compensation coefficient and the second hematocrit compensation coefficient according to the first fitting function of the true blood glucose concentration values ​​and the hematocrit background current test values ​​corresponding to the n×m blood glucose test samples; determine the third hematocrit compensation coefficient and the fourth hematocrit compensation coefficient according to the second fitting function of the hematocrit background current test values ​​and the hematocrit values ​​corresponding to the n×m blood glucose test samples.

[0061] The blood glucose test sample may be a blood sample required for blood glucose testing.

[0062] The true value of blood glucose concentration may be a plasma glucose concentration value determined by testing n×m blood glucose test samples using a laboratory standard instrument that achieves a preset accuracy in testing glucose. It should be understood that the accuracy of blood glucose testing using the laboratory standard instrument is relatively high, so the plasma glucose concentration value obtained by testing n×m blood glucose test samples using the laboratory standard instrument may be used as the true value of blood glucose concentration.

[0063] The hematocrit background current test value may be obtained by measuring the blood glucose test sample using a blood glucose measuring device using a blood glucose test strip to obtain the hematocrit background current value.

[0064] The hematocrit value may be a hematocrit value corresponding to a blood glucose test sample, and the hematocrit value is prepared according to test requirements.

[0065] The first fitting function may be a function generated by fitting the true blood glucose concentration values ​​and the hematocrit background current test values ​​corresponding to the n×m blood glucose test samples. As an example, the true blood glucose concentration values ​​and the hematocrit background current test values ​​corresponding to the n×m blood glucose test samples may be input into any fitting function software to generate the first fitting function.

[0066] The second fitting function may be a function generated by fitting the hematocrit background current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples. As an example, the hematocrit background current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples may be input into the fitting function software to generate the second fitting function.

[0067] It should be noted that, in actual use, the fitting function software and the type of fitting function can be selected according to actual needs and specific application scenarios, and this application does not limit this in real time. For example, the fitting function software can be MATLAB, which is a tool that can be used for fitting functions. In MATLAB, the function type can be arbitrarily selected, and the function type can be a linear function, a quadratic function, or a multiple function, etc. If a linear function is selected, a linear function will be output, if a quadratic function is selected, a quadratic function will be output, and if a multiple function is selected, a multiple function will be output. In the embodiment of the present application, the first fitting function and the second fitting function choose to use a linear function, a quadratic function, or a multiple function, which can be determined according to the reaction principle, and this embodiment of the present application does not limit this.

[0068] Furthermore, the first hematocrit compensation coefficient may be the coefficient of the highest-order term of the first fitting function; the second hematocrit compensation coefficient may be the constant term of the first fitting function; the third hematocrit compensation coefficient may be the coefficient of the highest-order term of the second fitting function; and the fourth hematocrit compensation coefficient may be the constant term of the second fitting function.

[0069] As a possible implementation method, n×m blood glucose test samples with n blood glucose concentrations and m hematocrit combinations can be prepared in advance, and the n×m blood glucose test samples are respectively represented by HCT 1-1 , HCT 1-2 , HCT 1-3 ...HCT 1-m , HCT 2-1 , HCT 2-2 , HCT 2-3 ...HCT 2-m , HCT n-1 , HCT n-2 , HCT n-3 ...HCT n-m ; The plasma blood glucose concentration (mg / dL) of the above n×m blood glucose test samples is tested using a laboratory standard instrument and expressed as: C 1-1 , C 1-2 , C 1-3 ……C 1-m , C 2-1 , C 2-2 , C 2-3 ……C 2-m , C n-1 , C n-2 , C n-3 ……C n-m .

[0070] Under normal temperature and humidity conditions, a blood glucose measuring device using blood glucose test strips and blood glucose test strips from the same production batch are used to test n×m blood glucose test samples to obtain hematocrit background current test values. The hematocrit background current test values ​​of n×m blood glucose test samples are expressed as: I HCT1-1 ,I HCT1-2 ,I HCT1-3 ……I HCT1-m ,I HCT2-1 ,I HCT2-2 ,I HCT2-3 ……I HCT2-m ,I HCTn-1 ,I HCTn-2 ,I HCTn-3 ……I HCTn-m .

[0071] As a possible implementation, C 1-1 , C 1-2 , C 1-3 ……C 1-m , C 2-1 , C 2-2 , C 2-3 ……C 2-m , C n-1 , C n-2 , C n-3 ……C n-m is the horizontal axis, I HCT1-1 ,I HCT1-2 ,I HCT1-3 ……I HCT1-m ,I HCT2-1 ,I HCT2-2 ,I HCT2-3 ……I HCT2-m ,I HCTn-1 ,I HCTn-2 ,I HCTn-3 ……I HCTn-m The vertical coordinate is fitted to generate a first fitting function, and the highest-order coefficient of the first fitting function can be determined as the first hematocrit compensation coefficient K1, and the constant term of the first fitting function can be determined as the second hematocrit compensation coefficient B1. The first fitting function can be a linear function, a quadratic function, or more.

[0072] As a possible implementation method, HCT 1-1 , HCT 1-2 , HCT 1-3 ...HCT 1-m , HCT 2-1 , HCT 2-2 , HCT 2-3 ...HCT 2-m , HCT n-1 , HCT n-2, HCT n-3 ...HCT n-m is the horizontal axis, I HCT1-1 ,I HCT1-2 ,I HCT1-3 ……I HCT1-m ,I HCT2-1 ,I HCT2-2 ,I HCT2-3 ……I HCT2-m ,I HCTn-1 ,I HCTn-2 ,I HCTn-3 ……I HCTn-m The ordinate is fitted to generate a second fitting function, the highest-order coefficient of the second fitting function can be determined as the third hematocrit compensation coefficient K2, and the constant term of the second fitting function can be determined as the fourth hematocrit compensation coefficient B2. The second fitting function can be a linear function, a quadratic function, or a multi-time function.

[0073] Step 304, determining the blood glucose concentration of the blood sample to be tested according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient.

[0074] The blood sugar concentration compensation coefficient may be a coefficient related to blood sugar concentration in blood sugar detection. The blood sugar concentration compensation coefficient includes: a first blood sugar concentration compensation coefficient, a second blood sugar concentration compensation coefficient, a third blood sugar concentration compensation coefficient and a fourth blood sugar concentration compensation coefficient.

[0075] As a possible implementation, the compensated hematocrit value and blood glucose current value can be input into the blood glucose concentration compensation function to output the blood glucose concentration of the blood sample to be tested. That is, the above step 304 can include:

[0076] The compensated hematocrit value and blood glucose current value are input into the blood glucose concentration compensation function, and the blood glucose concentration of the blood sample to be tested is output, wherein the blood glucose concentration compensation function is:

[0077]

[0078] Among them, C Glu is the blood glucose concentration of the blood sample to be tested, I w is the blood glucose current value, HCT comp is the compensated hematocrit value, K3 is the first blood glucose concentration compensation coefficient, B3 is the second blood glucose concentration compensation coefficient, K4 is the third blood glucose concentration compensation coefficient, and B4 is the fourth blood glucose concentration compensation coefficient.

[0079] As a possible implementation method, the first blood glucose concentration compensation coefficient, the second blood glucose concentration compensation coefficient, the third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient can be determined in the following manner: pre-prepare n×m blood glucose test samples with n blood glucose concentrations and m hematocrit combinations; obtain the true blood glucose concentration values, blood glucose current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples, wherein the blood glucose current test values ​​are obtained by testing the n×m blood glucose test samples with blood glucose test strips from the same batch as the blood glucose test strips; determine the first blood glucose concentration compensation coefficient and the second blood glucose concentration compensation coefficient based on a third fitting function of the true blood glucose concentration values ​​and the blood glucose current test values ​​corresponding to the n×m blood glucose test samples; determine the third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient based on a fourth fitting function of the blood glucose current test values ​​and the hematocrit values ​​corresponding to the n×m blood glucose test samples.

[0080] The blood glucose current test value may be obtained by measuring the blood glucose test sample using a blood glucose measuring device using a blood glucose test strip.

[0081] The hematocrit value may be a hematocrit value corresponding to a blood glucose test sample, and the hematocrit value is prepared according to test requirements.

[0082] The third fitting function may be a function generated by fitting the true blood glucose concentration values ​​and the blood glucose current test values ​​corresponding to the n×m blood glucose test samples. As an example, the true blood glucose concentration values ​​and the blood glucose current test values ​​corresponding to the n×m blood glucose test samples may be input into any fitting function software to generate the third fitting function.

[0083] The fourth fitting function may be a function generated by fitting the blood glucose current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples. As an example, the blood glucose current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples may be input into the fitting function software to generate the fourth fitting function.

[0084] It should be noted that, in actual use, the fitting function software and the type of fitting function can be selected according to actual needs and specific application scenarios, and this application does not limit this in real time. For example, the fitting function software can be MATLAB, which is a tool that can be used for fitting functions. In MATLAB, the function type can be arbitrarily selected, and the function type can be a linear function, a quadratic function, or a multiple function, etc. If a linear function is selected, a linear function will be output, if a quadratic function is selected, a quadratic function will be output, and if a multiple function is selected, a multiple function will be output. In the embodiment of the present application, the first fitting function and the second fitting function choose to use a linear function, a quadratic function, or a multiple function, which can be determined according to the reaction principle, and this embodiment of the present application does not limit this.

[0085] Furthermore, the first blood glucose concentration compensation coefficient may be the coefficient of the highest-order term of the third fitting function; the second blood glucose concentration compensation coefficient may be the constant term of the third fitting function; the third blood glucose concentration compensation coefficient may be the coefficient of the highest-order term of the fourth fitting function; and the fourth blood glucose concentration compensation coefficient may be the constant term of the fourth fitting function.

[0086] As a possible implementation method, n×m blood glucose test samples with n blood glucose concentrations and m hematocrit combinations can be prepared in advance, and the n×m blood glucose test samples are respectively represented by HCT 1-1 , HCT 1-2 , HCT 1-3 ...HCT 1-m , HCT 2-1 , HCT 2-2 , HCT 2-3 ...HCT 2-m , HCT n-1 , HCT n-2 , HCT n-3 ...HCT n-m ; The plasma blood glucose concentration (mg / dL) of the above n×m blood glucose test samples is tested using a laboratory standard instrument and expressed as: C 1-1 , C 1-2 , C 1-3 ……C 1-m , C 2-1 , C 2-2 , C 2-3 ……C 2-m , C n-1 , C n-2 , C n-3 ……C n-m .

[0087] Under normal temperature and humidity conditions, a blood glucose measuring device using blood glucose test strips and blood glucose test strips from the same production batch are used to test n×m blood glucose test samples to obtain blood glucose current test values. The blood glucose current test values ​​of the n×m blood glucose test samples are expressed as I W1-1 ,I W1-2 ,I W1-3 ……I W1-m ,I W2-1 ,I W2-2 ,I W2-3 ……I W2-m ,I Wn-1 ,I Wn-2 ,I Wn-3 ……I Wn-m .

[0088] As a possible implementation, C 1-1 , C 1-2 , C 1-3 ……C 1-m , C 2-1 , C 2-2 , C 2-3 ……C 2-m , C n-1 , C n-2 , C n-3 ……C n-m is the horizontal axis, I W1-1 ,I W1-2 ,I W1-3 ……I W1-m ,I W2-1 ,I W2-2 ,I W2-3 ……I W2-m ,I Wn-1 ,I Wn-2 ,I Wn-3 ……I Wn-m The vertical coordinate is fitted to generate a third fitting function, and the highest-order coefficient of the third fitting function can be determined as the first blood glucose concentration compensation coefficient K3, and the constant term of the third fitting function can be determined as the second blood glucose concentration compensation coefficient B3. The third fitting function can be a linear function, a quadratic function or a multi-time function.

[0089] As a possible implementation method, HCT 1-1 , HCT 1-2 , HCT 1-3 ...HCT 1-m , HCT 2-1 , HCT 2-2 , HCT 2-3 ...HCT 2-m , HCT n-1 , HCT n-2 , HCTn-3 ...HCT n-m is the horizontal axis, I W1-1 ,I W1-2 ,I W1-3 ……I W1-m ,I W2-1 ,I W2-2 ,I W2-3 ……I W2-m ,I Wn-1 ,I Wn-2 ,I Wn-3 ……I Wn-m The fourth fitting function is generated by fitting the vertical coordinate, and the highest-order coefficient of the fourth fitting function can be determined as the third blood glucose concentration compensation coefficient K4, and the constant term of the fourth fitting function can be determined as the fourth blood glucose concentration compensation coefficient B4. The fourth fitting function can be a linear function, a quadratic function or a multi-time function.

[0090] The blood glucose detection method provided in the embodiment of the present application is to collect the hematocrit background current value of the blood sample to be tested at the first preset time point after the voltage is applied to the first pair of electrodes when the blood sample to be tested contacts the biological enzyme on the blood glucose test paper, and then collect the blood glucose current of the blood sample to be tested at the second preset time point after the voltage is applied to the second pair of electrodes; and then determine the compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; and then determine the blood glucose concentration of the blood sample to be tested according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient. Thus, the effect of hematocrit on blood glucose concentration is quantified by the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient, and the compensated hematocrit value is obtained, and then the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose concentration compensation coefficient to obtain the blood glucose concentration of the blood sample to be tested, thereby further significantly reducing the interference of hematocrit on blood glucose testing in blood and improving the accuracy of blood glucose test results.

[0091] In order to further clearly verify the beneficial effects of the present application, 30 blood glucose test samples with 6 blood glucose concentrations and 5 hematocrit combinations were prepared for experimental testing, that is, n=6, m=5, as follows:

[0092] 30 blood glucose test samples were tested using a standard laboratory instrument. The true values ​​of blood glucose concentrations of the 30 blood glucose test samples obtained by the test are shown in Tables 1 to 4.

[0093] Under normal temperature and humidity conditions, a blood glucose measuring device using blood glucose test strips and blood glucose test strips from the same production batch were used to test 30 blood glucose test samples to obtain the hematocrit background current value I HCT and blood glucose current value I W, see Table 1 and Table 2, where each blood glucose test sample was tested 5 times in parallel:

[0094] Table 1: Hematocrit background current values ​​I corresponding to 30 blood glucose test samples HCT and average table

[0095]

[0096] Table 2: Blood glucose current values ​​I corresponding to 30 blood glucose test samples W and average table

[0097]

[0098] According to the hematocrit background current values ​​corresponding to the 30 blood glucose test samples in Table 1 and the blood glucose current values ​​corresponding to the 30 blood glucose test samples in Table 2, the compensated hematocrit value is calculated using the above-mentioned hematocrit compensation function. The hematocrit compensation coefficient in the hematocrit compensation function is the hematocrit compensation coefficient corresponding to the blood glucose test strips of the production batch, see Table 3:

[0099] Table 3: Compensated hematocrit values ​​corresponding to 30 blood glucose test samples

[0100]

[0101] According to the hematocrit background current values ​​corresponding to the 30 blood glucose test samples in Table 1, the blood glucose current values ​​corresponding to the 30 blood glucose test samples in Table 2, and the compensated hematocrit values ​​corresponding to the 30 blood glucose test samples in Table 3, the blood glucose concentration is calculated by the above-mentioned blood glucose concentration compensation function. The blood glucose concentration compensation coefficient in the blood glucose concentration compensation function is the blood glucose concentration compensation coefficient corresponding to the blood glucose test strips of the production batch, see Table 4:

[0102] Table 4: Blood glucose concentration and average value corresponding to 30 blood glucose test samples

[0103]

[0104] From Table 4, it can be seen that the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose concentration compensation coefficient. The error between the obtained blood glucose concentration and the true value of the blood glucose concentration is within the blood glucose measurement error standard in this field, and the error is small. The blood glucose detection method of the present application improves the accuracy of the blood glucose test results.

[0105] It should be understood that although Figure 1-Figure 2The steps in the flowchart are shown in sequence as indicated by the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified in this document, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover, Figure 1-Figure 2 At least part of the steps may include multiple steps or multiple stages. These steps or stages are not necessarily performed at the same time, but can be performed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed in turn or alternately with other steps or at least part of the steps or stages in other steps.

[0106] In one embodiment, Figure 3 As shown, a blood glucose detection device is provided. The device can adopt a software module or a hardware module, or a combination of the two to become a part of a computer device. The device specifically includes: a first acquisition module 410, a second acquisition module 420 and a detection module 430.

[0107] The first acquisition module 410 is used to collect the hematocrit background current value of the blood sample to be tested at a first preset time point after the blood sample to be tested contacts the biological enzyme on the blood glucose test strip and a voltage is applied to the first pair of electrodes.

[0108] The second acquisition module 420 is used to collect the blood glucose current value of the blood sample to be tested at a second preset time point after the voltage is applied to the second pair of electrodes.

[0109] The detection module 430 is used to determine the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip.

[0110] The blood glucose detection device provided in the embodiment of the present application collects the hematocrit background current value of the blood sample to be tested at a first preset time point after a voltage is applied to a first pair of electrodes by bringing the blood sample to be tested into contact with the biological enzyme on the blood glucose test strip, and then collects the blood glucose current value of the blood sample to be tested at a second preset time point after a voltage is applied to a second pair of electrodes; and then determines the blood glucose concentration of the blood sample to be tested based on the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip, thereby converting the blood glucose concentration based on the compensation coefficient corresponding to the blood glucose test strip, the hematocrit background current value and the blood glucose current value, thereby significantly reducing the interference of the hematocrit on the blood glucose test in the blood, and improving the accuracy of the blood glucose test result.

[0111] In one embodiment, the compensation coefficients corresponding to the blood glucose test strip include: a hematocrit compensation coefficient and a blood glucose concentration compensation coefficient. The detection module 430 is also used to: determine the compensated hematocrit value based on the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; determine the blood glucose concentration of the blood sample to be tested based on the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient.

[0112] In one embodiment, the hematocrit compensation coefficient includes: a first hematocrit compensation coefficient, a second hematocrit compensation coefficient, a third hematocrit compensation coefficient and a fourth hematocrit compensation coefficient. The detection module 430 is further used to: input the hematocrit background current value and the blood glucose current value into the hematocrit compensation function, and output the compensated hematocrit value, wherein the hematocrit compensation function is:

[0113]

[0114] Among them, HCT comp is the hematocrit value after compensation, I HCT is the background current value of hematocrit, I w is the blood glucose current value, K1 is the first hematocrit compensation coefficient, B1 is the second hematocrit compensation coefficient, K2 is the third hematocrit compensation coefficient, and B2 is the fourth hematocrit compensation coefficient.

[0115] In one embodiment, the hematocrit compensation coefficient is determined in the following manner: n×m blood glucose test samples of n blood glucose concentrations and m hematocrit combinations are prepared in advance; the true blood glucose concentration values, hematocrit background current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples are obtained, wherein the hematocrit background current test values ​​are obtained by testing the n×m blood glucose test samples with blood glucose test strips from the same batch as the blood glucose test strips; the first hematocrit compensation coefficient and the second hematocrit compensation coefficient are determined based on a first fitting function of the true blood glucose concentration values ​​and the hematocrit background current test values ​​corresponding to the n×m blood glucose test samples; the third hematocrit compensation coefficient and the fourth hematocrit compensation coefficient are determined based on a second fitting function of the hematocrit background current test values ​​and the hematocrit values ​​corresponding to the n×m blood glucose test samples.

[0116] In one embodiment, the first hematocrit compensation coefficient is the coefficient of the highest-order term of the first fitting function; the second hematocrit compensation coefficient is the constant term of the first fitting function; the third hematocrit compensation coefficient is the coefficient of the highest-order term of the second fitting function; and the fourth hematocrit compensation coefficient is the constant term of the second fitting function.

[0117] In one embodiment, the blood glucose concentration compensation coefficient includes: a first blood glucose concentration compensation coefficient, a second blood glucose concentration compensation coefficient, a third blood glucose concentration compensation coefficient and a fourth blood glucose concentration compensation coefficient. The detection module 430 is further used to: input the compensated hematocrit value and the blood glucose current value into the blood glucose concentration compensation function, and output the blood glucose concentration of the blood sample to be tested, wherein the blood glucose concentration compensation function is:

[0118]

[0119] Among them, C Glu is the blood glucose concentration of the blood sample to be tested, I w is the blood glucose current value, HCT comp is the compensated hematocrit value, K3 is the first blood glucose concentration compensation coefficient, B3 is the second blood glucose concentration compensation coefficient, K4 is the third blood glucose concentration compensation coefficient, and B4 is the fourth blood glucose concentration compensation coefficient.

[0120] In one embodiment, the blood glucose concentration compensation coefficient is determined in the following manner: n×m blood glucose test samples of n blood glucose concentrations and m hematocrit combinations are prepared in advance; the true blood glucose concentration values, blood glucose current test values ​​and hematocrit values ​​corresponding to the n×m blood glucose test samples are obtained, wherein the blood glucose current test values ​​are obtained by testing the n×m blood glucose test samples with blood glucose test strips from the same batch as the blood glucose test strips; the first blood glucose concentration compensation coefficient and the second blood glucose concentration compensation coefficient are determined based on a third fitting function of the true blood glucose concentration values ​​and the blood glucose current test values ​​corresponding to the n×m blood glucose test samples; the third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient are determined based on a fourth fitting function of the blood glucose current test values ​​and the hematocrit values ​​corresponding to the n×m blood glucose test samples.

[0121] In one embodiment, the first blood glucose concentration compensation coefficient is the coefficient of the highest order term of the third fitting function; the second blood glucose concentration compensation coefficient is the constant term of the third fitting function; the third blood glucose concentration compensation coefficient is the coefficient of the highest order term of the fourth fitting function; and the fourth blood glucose concentration compensation coefficient is the constant term of the fourth fitting function.

[0122] The blood glucose detection device provided in the embodiment of the present application, by contacting the blood sample to be tested with the biological enzyme on the blood glucose test paper, collecting the hematocrit background current value of the blood sample to be tested at the first preset time point after applying voltage to the first pair of electrodes, and then collecting the blood glucose current of the blood sample to be tested at the second preset time point after applying voltage to the second pair of electrodes; then determining the compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient; and then determining the blood glucose concentration of the blood sample to be tested according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient. Thus, the effect of hematocrit on blood glucose concentration is quantified by the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient, and the compensated hematocrit value is obtained, and then the blood glucose current value is corrected according to the compensated hematocrit value and the blood glucose concentration compensation coefficient to obtain the blood glucose concentration of the blood sample to be tested, thereby further significantly reducing the interference of hematocrit on blood glucose testing in blood, and improving the accuracy of blood glucose test results.

[0123] For the specific definition of the blood glucose detection device, please refer to the definition of the blood glucose detection method above, which will not be repeated here. Each module in the above-mentioned blood glucose detection device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.

[0124] Figure 4 Schematic diagram of the structure of a blood sugar detection device provided in one embodiment of the present application. Figure 4 As shown, the blood glucose detection device 700 of this embodiment includes: at least one processor 710 ( Figure 4 (only one is shown in the figure) a processor, a memory 720, and a computer program 721 stored in the memory 720 and executable on at least one processor 710, and when the processor 710 executes the computer program 721, the steps in the above-mentioned blood glucose detection method embodiment are implemented.

[0125] The blood glucose detection device 700 may be a device for blood glucose detection such as a desktop computer, a notebook, a blood glucose meter, a PDA, or a cloud server. The blood glucose detection device may include, but is not limited to, a processor 710 and a memory 720. Those skilled in the art will appreciate that Figure 4 It is merely an example of the blood glucose testing device 700 and does not constitute a limitation of the blood glucose testing device 700. It may include more or fewer components than shown in the figure, or a combination of certain components, or different components. For example, it may also include input and output devices, network access devices, etc.

[0126] The processor 710 may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or any conventional processor, etc.

[0127] The memory 720 may be an internal storage unit of the blood glucose detection device 700 in some embodiments, such as a hard disk or memory of the blood glucose detection device 700. The memory 720 may also be an external storage device of the blood glucose detection device 700 in other embodiments, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), etc. equipped on the blood glucose detection device 700. Further, the memory 720 may also include both an internal storage unit and an external storage device of the blood glucose detection device 700. The memory 720 is used to store an operating system, an application program, a boot loader (Boot Loader), data, and other programs, such as program codes of computer programs, etc. The memory 720 may also be used to temporarily store data that has been output or is to be output.

[0128] The technicians in the relevant field can clearly understand that for the convenience and simplicity of description, only the division of the above-mentioned functional units and modules is used as an example for illustration. In practical applications, the above-mentioned function allocation can be completed by different functional units and modules as needed, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above. The functional units and modules in the embodiment can be integrated in a processing unit, or each unit can exist physically separately, or two or more units can be integrated in one unit. The above-mentioned integrated unit can be implemented in the form of hardware or in the form of software functional units. In addition, the specific names of the functional units and modules are only for the convenience of distinguishing each other, and are not used to limit the scope of protection of this application. The specific working process of the units and modules in the above-mentioned system can refer to the corresponding process in the aforementioned method embodiment, which will not be repeated here.

[0129] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0130] Those of ordinary skill in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professional and technical personnel can use different methods to implement the described functions for each specific application, but such implementation should not be considered to be beyond the scope of this application.

[0131] In the embodiments provided in the present application, it should be understood that the disclosed device / blood sugar detection equipment and method can be implemented in other ways. For example, the device / blood sugar detection equipment embodiments described above are merely schematic. For example, the division of the modules or units is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, the indirect coupling or communication connection of the device or unit can be electrical, mechanical or other forms.

[0132] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0133] In addition, each functional unit in each embodiment of the present application may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units.

[0134] If the integrated module / unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the present application implements all or part of the processes in the above-mentioned embodiment method, and can also be completed by instructing the relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium, and the computer program can implement the steps of the above-mentioned various method embodiments when executed by the processor. Among them, the computer program includes computer program code, and the computer program code can be in source code form, object code form, executable file or some intermediate form. The computer-readable medium may include: any entity or device capable of carrying the computer program code, recording medium, U disk, mobile hard disk, disk, optical disk, computer memory, read-only memory (ROM), random access memory (RAM), electric carrier signal, telecommunication signal and software distribution medium. It should be noted that the content contained in the computer-readable medium can be appropriately increased or decreased according to the requirements of legislation and patent practice in the jurisdiction. For example, in some jurisdictions, according to legislation and patent practice, computer-readable media do not include electric carrier signals and telecommunication signals.

[0135] The present application implements all or part of the processes in the above-mentioned embodiment method, and can also be completed through a computer program product. When the computer program product runs on a blood glucose testing device, the blood glucose testing device can implement the steps in the above-mentioned method embodiments when executed.

[0136] The above-described embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application is described in detail with reference to the above-mentioned embodiments, a person skilled in the art should understand that the technical solutions described in the above-mentioned embodiments can still be modified, or some of the technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application, and should be included in the protection scope of the present application.

Claims

1. A blood sugar detection method, characterized in that: include: When the blood sample to be tested contacts the biological enzyme on the blood glucose test strip and a voltage is applied to the first pair of electrodes, a hematocrit background current value of the blood sample to be tested is collected at a first preset time point; At a second preset time point after the voltage is applied to the second pair of electrodes, collecting the blood glucose current value of the blood sample to be tested; Determining a compensated hematocrit value according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient corresponding to the blood glucose test strip; Determining the blood glucose concentration of the blood sample to be tested according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient corresponding to the blood glucose test strip; The hematocrit compensation coefficient includes: a first hematocrit compensation coefficient, a second hematocrit compensation coefficient, a third hematocrit compensation coefficient and a fourth hematocrit compensation coefficient, and the hematocrit value after compensation is determined according to the hematocrit background current value, the blood glucose current value and the hematocrit compensation coefficient corresponding to the blood glucose test strip, including: The hematocrit background current value and the blood glucose current value are input into a hematocrit compensation function, and the compensated hematocrit value is output, wherein the hematocrit compensation function is: Among them, HCT comp is the hematocrit value after compensation, I HCT is the hematocrit background current value, I w is the blood glucose current value, K1 is the first hematocrit compensation coefficient, B1 is the second hematocrit compensation coefficient, K2 is the third hematocrit compensation coefficient, and B2 is the fourth hematocrit compensation coefficient; Wherein, the blood glucose concentration compensation coefficient includes: a first blood glucose concentration compensation coefficient, a second blood glucose concentration compensation coefficient, a third blood glucose concentration compensation coefficient and a fourth blood glucose concentration compensation coefficient, and the blood glucose concentration of the blood sample to be tested is determined according to the compensated hematocrit value, the blood glucose current value and the blood glucose concentration compensation coefficient corresponding to the blood glucose test strip, including: The compensated hematocrit value and the blood glucose current value are input into a blood glucose concentration compensation function, and the blood glucose concentration of the blood sample to be tested is output, wherein the blood glucose concentration compensation function is: Among them, C Glu is the blood glucose concentration of the blood sample to be tested, I w is the blood glucose current value, HCT comp is the compensated hematocrit value, K3 is the first blood glucose concentration compensation coefficient, B3 is the second blood glucose concentration compensation coefficient, K4 is the third blood glucose concentration compensation coefficient, and B4 is the fourth blood glucose concentration compensation coefficient.

2. The blood sugar detection method according to claim 1, characterized in that: The hematocrit compensation factor is determined by: n×m blood glucose test samples with n combinations of blood glucose concentrations and m combinations of hematocrits are prepared in advance; Obtaining the true value of blood glucose concentration, hematocrit background current test value and hematocrit value corresponding to n×m blood glucose test samples, wherein the hematocrit background current test value is obtained by testing n×m blood glucose test samples with blood glucose test strips from the same batch as the blood glucose test strips; determining the first hematocrit compensation coefficient and the second hematocrit compensation coefficient according to a first fitting function of the true blood glucose concentration values ​​and the hematocrit background current test values ​​corresponding to n×m blood glucose test samples; The third hematocrit compensation coefficient and the fourth hematocrit compensation coefficient are determined according to the hematocrit background current test values ​​and the second fitting function of the hematocrit values ​​corresponding to the n×m blood sugar test samples.

3. The blood sugar detection method according to claim 2, characterized in that: The first hematocrit compensation coefficient is the coefficient of the highest-order term of the first fitting function; the second hematocrit compensation coefficient is the constant term of the first fitting function; the third hematocrit compensation coefficient is the coefficient of the highest-order term of the second fitting function; and the fourth hematocrit compensation coefficient is the constant term of the second fitting function.

4. The blood glucose detection method according to any one of claims 1 to 3, characterized in that: The blood glucose concentration compensation coefficient is determined by: n×m blood glucose test samples with n combinations of blood glucose concentrations and m combinations of hematocrits are prepared in advance; Obtaining the true value of blood glucose concentration, blood glucose current test value and hematocrit value corresponding to n×m blood glucose test samples, wherein the blood glucose current test value is obtained by testing n×m blood glucose test samples using blood glucose test strips from the same batch as the blood glucose test strips; determining the first blood glucose concentration compensation coefficient and the second blood glucose concentration compensation coefficient according to a third fitting function of the true blood glucose concentration values ​​and the blood glucose current test values ​​corresponding to the n×m blood glucose test samples; The third blood glucose concentration compensation coefficient and the fourth blood glucose concentration compensation coefficient are determined according to a fourth fitting function of the blood glucose current test values ​​and the hematocrit values ​​corresponding to the n×m blood glucose test samples.

5. The blood sugar detection method according to claim 4, characterized in that: The first blood glucose concentration compensation coefficient is the coefficient of the highest-order term of the third fitting function; the second blood glucose concentration compensation coefficient is the constant term of the third fitting function; the third blood glucose concentration compensation coefficient is the coefficient of the highest-order term of the fourth fitting function; and the fourth blood glucose concentration compensation coefficient is the constant term of the fourth fitting function.

6. A blood sugar detection device, characterized in that: A method for detecting blood sugar according to any one of claims 1 to 5, comprising: A first acquisition module is used to acquire the hematocrit background current value of the blood sample to be tested at a first preset time point after a voltage is applied to a first pair of electrodes when the blood sample to be tested contacts the biological enzyme on the blood glucose test strip; A second acquisition module, used for acquiring the blood glucose current value of the blood sample to be tested at a second preset time point after the voltage is applied to the second pair of electrodes; The detection module is used to determine the blood glucose concentration of the blood sample to be tested according to the hematocrit background current value, the blood glucose current value and the compensation coefficient corresponding to the blood glucose test strip.

7. A blood glucose detection device, comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, characterized in that: When the processor executes the computer program, the method according to any one of claims 1 to 5 is implemented.

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