A method for preparing a nitrate-based three-dimensional gel discoloring dosimeter

Abstract

The application discloses a preparation method of a nitrate-based three-dimensional gel color change dosimeter, and comprises the following steps: dissolving a certain amount of nitrate in water to obtain a mixed solution I; adding a certain amount of a hydroxyl shielding agent to obtain a mixed solution II; adding a certain amount of a gel monomer, uniformly mixing, and heating to a certain temperature to obtain a mixed solution III; forming the gel monomer in the mixed solution III into a gel by a physical cross-linking method to obtain the gel dosimeter IV; adding a certain amount of a color developing agent to the surface of the gel dosimeter after the gel dosimeter is irradiated by high-energy rays for a certain dose, placing for 5 min to 20 min, removing the color developing agent on the surface of the gel, and thus the color change of gradually deepening color with the increase of the dose appears. The gel dosimeter can be used for detecting the treatment level of high-energy rays in clinical radiotherapy, the minimum detection limit is 0.1 Gy, the sensitivity is higher, the response speed is faster, and the gel dosimeter is more suitable for clinical radiotherapy dose detection.

Description

Technical Field

[0001] This invention relates to a three-dimensional gel colorimetric dosimeter, specifically a method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter, belonging to the field of radiotherapy technology. Background Technology

[0002] Radiotherapy, as one of the three major methods of cancer treatment, has advantages such as wide applicability, fewer side effects, and protection of normal tissues and organs, and is widely used in the medical field, especially in cancer treatment. However, due to the limitations of complex manufacturing, cumbersome operation, and the high cost associated with current dosimeters, accurately determining the dose around the tumor remains a challenge.

[0003] Currently, three-dimensional dose verification in clinical practice mostly relies on ionization chamber matrix interpolation to obtain three-dimensional dose distribution information. However, due to limitations in the size of the ionization chamber, this type of dosimeter has low resolution and high manufacturing costs. Radiotherapy doses can also be verified using dedicated human phantoms, but these phantoms are expensive and have a limited number of detectors, limiting their widespread application. Fricke gel dosimeters suffer from issues such as iron ion diffusion. Therefore, there is an urgent need for a new type of dose verification material that exhibits high sensitivity, fast response, significant color changes, ideally allowing for visual observation of dose distribution information through colorimetric changes, good tissue equivalence, and the ability to perform three-dimensional dose verification. Summary of the Invention

[0004] The purpose of this invention is to provide a method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter in order to solve the above-mentioned problems. This gel dosimeter is more accurate, convenient and quick to use in radiotherapy, and has higher sensitivity. It realizes colorimetric visualization and quantification of spatial dose distribution. The color change of the dosimeter under different doses of irradiation is very obvious, and three-dimensional dose verification can be performed.

[0005] This invention achieves the above objective through the following technical solution: a method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter, comprising the following steps:

[0006] A. A certain amount of nitrate is dissolved in water to obtain mixed solution I;

[0007] B. Add a certain amount of hydroxyl shielding agent to mixed solution I, mix well, and obtain mixed solution II;

[0008] C. Add a certain amount of hydrogel monomer to mixed solution II, mix well, and heat to a certain temperature to obtain mixed solution III;

[0009] D. The gel dosimeter IV is obtained by physically cross-linking the hydrogel monomers in mixed solution III to form a gel.

[0010] E. After a certain dose of high-energy radiation has been applied to the surface of the gel dosimeter IV, a certain amount of chromogenic agent is added and left for 5-20 minutes to obtain a color-changing gel. The chromogenic agent on the surface of the gel is then removed, resulting in a color change that gradually deepens with increasing dose.

[0011] Preferably, the nitrate in step A is any one or more of sodium nitrate, potassium nitrate, lithium nitrate, calcium nitrate, strontium nitrate, cesium nitrate, and magnesium nitrate, and the concentration of the nitrate is 0.5 mmol / L to 1000 mmol / L.

[0012] Preferably, the hydroxyl shielding agent in step B is any one or more of sodium formate, isopropanol, methanol, ethanol, tert-butanol, and sodium sulfite, and the concentration of the hydroxyl shielding agent is 0 mmol / L-1000 mmol / L.

[0013] Preferably, in step C, the hydrogel monomer is any one or more of agarose, agar, gelatin, gellan gum, and polyvinyl alcohol, and the heating temperature is 90℃-100℃.

[0014] Preferably, the mass fraction of agarose and agar is 1%-5%, the mass fraction of gelatin and polyvinyl alcohol is 10%-15%, and the mass fraction of gellan gum is 0.05%-0.3%.

[0015] Preferably, in step E, the high-energy rays include any one of X-rays, alpha rays, beta rays, gamma rays, electron beams, heavy ions, and protons.

[0016] Preferably, in step E, the absorbed dose of the color-changing gel is 0.1 Gy-20 Gy.

[0017] Preferably, in step E, the volume ratio of the colorimetric agent placed on the surface of the gel dosimeter to the volume of the gel dosimeter is 3:1 to 1:3.

[0018] Preferably, in step E, the concentration of naphthylethylenediamine hydrochloride in the colorimetric reagent is 1.3 mmol / L-13 mmol / L, sulfonamide is 0.04 mol / L-0.4 mol / L, and phosphoric acid is 3.2 mmol / L-32 mmol / L.

[0019] The beneficial effects of this invention are: the gel dosimeter can reach the therapeutic level for detecting high-energy rays in clinical radiotherapy, with a minimum detection limit of 0.1 Gy, higher sensitivity, faster response speed, and is more suitable for dose detection in clinical radiotherapy;

[0020] This invention proposes a method to reduce nitrate ions to nitrite ions through radiation, which then react with a chromogenic agent to visually change the color of the gel. The intensity of the color formed in the gel is used as a quantitative report of ionizing radiation, enabling dose visualization. This truly allows for real-time observation of the irradiated parts of the human body and the magnitude of the dose received in clinical practice. For clinical dose verification, tissue equivalence of materials must be considered. This project uses hydrogel as the base material, whose composition is very similar to human tissue, resulting in good tissue equivalence. Attached Figure Description

[0021] Figure 1 This is the ultraviolet spectrum of absorbed dose and absorbance of the three-dimensional gel radiotherapy dosimeter using sodium nitrate as the responsive material of this invention after being irradiated with different X-ray doses.

[0022] Figure 2 This is a linear relationship between absorbed dose and absorbance after the three-dimensional gel radiotherapy dosimeter of this invention, which uses sodium nitrate as the responsive material, is irradiated with different X-ray doses.

[0023] Figure 3 The images show the color changes of the three-dimensional gel radiotherapy dosimeter of this invention, which uses sodium nitrate as the responsive material, after being irradiated with doses of 0 Gy, 0.5 Gy, 2.5 Gy, 5 Gy, 7.5 Gy, 10 Gy, 12.5 Gy, and 15 Gy. Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] This invention discloses a method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter.

[0026] The steps include the following:

[0027] A. A certain amount of nitrate is dissolved in water to obtain mixed solution I;

[0028] B. Add a certain amount of hydroxyl shielding agent to mixed solution I, mix well, and obtain mixed solution II;

[0029] C. Add a certain amount of hydrogel monomer to mixed solution II, mix well, and heat to a certain temperature to obtain mixed solution III;

[0030] D. The gel dosimeter IV is obtained by physically cross-linking the hydrogel monomers in mixed solution III to form a gel.

[0031] E. After a certain dose of high-energy radiation has been applied to the surface of the gel dosimeter IV, a certain amount of chromogenic agent is added and left for 5-20 minutes to obtain a color-changing gel. The chromogenic agent on the surface of the gel is then removed, resulting in a color change that gradually deepens with increasing dose.

[0032] In step A, the nitrate is any one or more of sodium nitrate, potassium nitrate, lithium nitrate, calcium nitrate, strontium nitrate, cesium nitrate, and magnesium nitrate, and the concentration of the nitrate is 0.5 mmol / L to 1000 mmol / L.

[0033] The hydroxyl shielding agent in step B is any one or more of sodium formate, isopropanol, methanol, ethanol, tert-butanol, and sodium sulfite, and the concentration of the hydroxyl shielding agent is 0 mmol / L-1000 mmol / L.

[0034] In step C, the hydrogel monomer is any one or more of agarose, agar, gelatin, gellan gum, and polyvinyl alcohol, and the heating temperature is 90℃-100℃.

[0035] The agarose and agar content is 1%-5% by mass, the gelatin and polyvinyl alcohol content is 10%-15% by mass, and the gellan gum content is 0.05%-0.3% by mass.

[0036] In step E, the high-energy rays include any one of X-rays, alpha rays, beta rays, gamma rays, electron beams, heavy ions, and protons.

[0037] In step E, the absorbed dose of the color-changing gel is 0.1 Gy-20 Gy.

[0038] In step E, the volume ratio of the colorimetric reagent placed on the surface of the gel dosimeter to the volume of the gel dosimeter is 3:1 to 1:3.

[0039] In step E, the concentration of naphthylethylenediamine hydrochloride in the colorimetric reagent is 1.3 mmol / L-13 mmol / L, sulfonamide is 0.04 mol / L-0.4 mol / L, and phosphoric acid is 3.2 mmol / L-32 mmol / L.

[0040] Example 1:

[0041] (1) Dissolve 0.00085g of sodium nitrate in 20mL of ultrapure water (i.e., the concentration of sodium nitrate is 0.5mmol / L) to obtain mixed solution I;

[0042] (2) Add 0g of sodium formate (i.e., the concentration of sodium formate is 0mmol / L) to mixed solution I, mix well, and obtain transparent mixed solution II;

[0043] (3) Add 0.202 g of hydrogel monomer agarose (i.e., the mass fraction of agarose is 1%) to mixed solution II, mix well, and heat for a period of time at a temperature of 90°C to obtain mixed solution III;

[0044] (4) The gel dosimeter IV was obtained by physically cross-linking the gel monomer agarose in mixed solution III to form a gel;

[0045] (5) Add a colorimetric reagent with a volume ratio of 1:3 to the gel dosimeter to the surface of the gel dosimeter that has been irradiated with gamma rays, and let it stand for 5 min to 20 min. The colorimetric reagent is 0.007 g of naphthylethylenediamine hydrochloride, 0.13 g of sulfonamide, and 0.3 mL of phosphoric acid in 19.7 mL of ultrapure water (i.e., the concentration of naphthylethylenediamine hydrochloride is 1.3 mmol / L, sulfonamide is 0.04 mol / L, and phosphoric acid is 3.2 mmol / L). As a result, the color changes and gradually deepens with the increase of the dose.

[0046] Example 2:

[0047] (1) Dissolve 0.85g of sodium nitrate in 20mL of ultrapure water (i.e., the concentration of sodium nitrate is 500mmol / L) to obtain mixed solution I;

[0048] (2) Add 0.068g of sodium formate (i.e., the concentration of sodium formate is 5mmol / L) to mixed solution I, mix well, and obtain transparent mixed solution II;

[0049] (3) Add 0.408 g of hydrogel monomer agarose (i.e., the mass fraction of agarose is 2%) to mixed solution II, mix well, and heat for a period of time at a temperature of 95°C to obtain mixed solution III;

[0050] (4) The gel dosimeter IV was obtained by physically cross-linking the gel monomer agarose in mixed solution III to form a gel;

[0051] (5) A colorimetric reagent with a volume ratio of 1:1 was added to the surface of the gel dosimeter irradiated with X-rays. The mixture was left to stand for 5-20 minutes. The colorimetric reagent consisted of 0.007 g of naphthylethylenediamine hydrochloride, 0.13 g of sulfonamide, and 0.3 mL of phosphoric acid in 19.7 mL of ultrapure water (i.e., the concentrations of naphthylethylenediamine hydrochloride were 1.3 mmol / L, sulfonamide was 0.04 mol / L, and phosphoric acid was 3.2 mmol / L). This resulted in a color change where the color gradually deepened with increasing dose. From the figure, we can see that there is a good linear response relationship between the absorbed dose and absorbance of the gel dosimeter (r = 0.99472), and the color gradually deepens with increasing dose.

[0052] Example 3:

[0053] (1) Dissolve 1.7g of sodium nitrate in 20mL of ultrapure water (i.e., the concentration of sodium nitrate is 1000mmol / L) to obtain mixed solution I;

[0054] (2) Add 0.012 g of hydroxyl shielding agent methanol (i.e., methanol concentration of 1000 mmol / L) to mixed solution I, mix well, and obtain transparent mixed solution II;

[0055] (3) Add 0.408 g of hydrogel monomer agarose (i.e., the mass fraction of agarose is 2%) to mixed solution II, mix well, and heat for a period of time at a temperature of 100℃ to obtain mixed solution III;

[0056] (4) The gel dosimeter IV was obtained by physically cross-linking the gel monomer agarose in mixed solution III to form a gel;

[0057] (5) Add a colorimetric reagent with a volume ratio of 3:1 to the gel dosimeter to the surface of the gel dosimeter that has been irradiated by electron beams, and let it stand for 5 min to 20 min. The colorimetric reagent is 0.07 g of naphthylethylenediamine hydrochloride, 1.3 g of sulfonamide, and 3 mL of phosphoric acid in 17 mL of ultrapure water (i.e., the concentration of naphthylethylenediamine hydrochloride is 13 mmol / L, the concentration of sulfonamide is 0.4 mol / L, and the concentration of phosphoric acid is 32 mmol / L).

[0058] Example 4:

[0059] (1) Dissolve 1.7g of sodium nitrate in 20mL of ultrapure water (i.e., the concentration of sodium nitrate is 1000mmol / L) to obtain mixed solution I;

[0060] (2) Add 1.2g of hydroxyl shielding agent isopropanol (i.e., sodium formate concentration of 1000mmol / L) to mixed solution I, mix well, and obtain transparent mixed solution II;

[0061] (3) Add 0.408 g of hydrogel monomer agarose (i.e., the mass fraction of agarose is 2%) to mixed solution II, mix well, and heat for a period of time at a temperature of 100℃ to obtain mixed solution III;

[0062] (4) The gel dosimeter IV was obtained by physically cross-linking the gel monomer agarose in mixed solution III to form a gel;

[0063] (5) Add a colorimetric reagent with a volume ratio of 3:1 to the gel dosimeter to the surface of the gel dosimeter that has been irradiated by proton rays, and let it stand for 5 min to 20 min. The colorimetric reagent is 0.07 g of naphthylethylenediamine hydrochloride, 1.3 g of sulfonamide, and 3 mL of phosphoric acid in 17 mL of ultrapure water (i.e., the concentration of naphthylethylenediamine hydrochloride is 13 mmol / L, the concentration of sulfonamide is 0.4 mol / L, and the concentration of phosphoric acid is 32 mmol / L). As a result, the color changes gradually deepens with the increase of the dose.

[0064] Example 5:

[0065] (1) Dissolve 1.7g of sodium nitrate in 20mL of ultrapure water (i.e., the concentration of sodium nitrate is 1000mmol / L) to obtain mixed solution I;

[0066] (2) Add 1.36g of sodium formate (i.e., the concentration of sodium formate is 1000mmol / L) to mixed solution I, mix well, and obtain transparent mixed solution II;

[0067] (3) Add 1.05g of hydrogel monomer agarose (i.e., the mass fraction of agarose is 5%) to mixed solution II, mix well, and heat for a period of time at a temperature of 100℃ to obtain mixed solution III;

[0068] (4) The gel dosimeter IV was obtained by physically cross-linking the gel monomer agarose in mixed solution III to form a gel;

[0069] (5) Add a colorimetric reagent with a volume ratio of 3:1 to the gel dosimeter to the surface of the gel dosimeter that has been irradiated by β rays, and let it stand for 5 min to 20 min. The colorimetric reagent is 0.07 g of naphthylethylenediamine hydrochloride, 1.3 g of sulfonamide, and 3 mL of phosphoric acid in 17 mL of ultrapure water (i.e., the concentration of naphthylethylenediamine hydrochloride is 13 mmol / L, the concentration of sulfonamide is 0.4 mol / L, and the concentration of phosphoric acid is 32 mmol / L). As a result, the color changes gradually deepens with the increase of the dose.

[0070] Example 6:

[0071] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 1, except that 2.2 g of gelatin (i.e., the mass fraction of gelatin) was added.

[0072] Example 7:

[0073] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that 5g of gelatin (i.e., the mass fraction of gelatin) was added.

[0074] Example 8:

[0075] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 4, except that 5g of polyvinyl alcohol (i.e., the mass fraction of gelatin) was added.

[0076] Example 9:

[0077] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that 5g of polyvinyl alcohol (i.e., the mass fraction of gelatin) was added.

[0078] Example 10:

[0079] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method of Example 1, except that 0.01 g of gellan gum monomer was added (i.e., the mass fraction of gellan gum was 0.05%).

[0080] Example 11:

[0081] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that 0.06 g of gellan gum monomer was added (i.e., the mass fraction of gellan gum was 0.3%).

[0082] Example 12:

[0083] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 4, except that 0.06 g of gellan gum monomer was added (i.e., the mass fraction of gellan gum was 0.3%).

[0084] Example 13:

[0085] The nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that 0.06 g of gellan gum monomer was added (i.e., the mass fraction of gellan gum was 0.3%).

[0086] Example 14:

[0087] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 1, except that the nitrate used was potassium nitrate, and the amount of potassium nitrate added was 0.001 g (i.e., the concentration of potassium nitrate was 0.5 mmol / L).

[0088] Example 15:

[0089] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 6, except that the nitrate was potassium nitrate and the amount of potassium nitrate added was 0.001 g (i.e., the concentration of potassium nitrate was 0.5 mmol / L).

[0090] Example 16:

[0091] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method of Example 10, except that the nitrate was potassium nitrate and the amount of potassium nitrate added was 0.001 g (i.e., the concentration of potassium nitrate was 0.5 mmol / L).

[0092] Example 17:

[0093] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0094] Example 18:

[0095] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 4, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0096] Example 19:

[0097] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0098] Example 20:

[0099] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 7, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0100] Example 21:

[0101] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 8, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0102] Example 22:

[0103] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 9, except that the nitrate was potassium nitrate and the amount of potassium nitrate added was 2.02 g (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0104] Example 23:

[0105] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 11, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0106] Example 24:

[0107] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 12, except that the nitrate was potassium nitrate and the amount of potassium nitrate added was 2.02 g (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0108] Example 25:

[0109] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 13, except that the nitrate was potassium nitrate and 2.02 g of potassium nitrate was added (i.e., the concentration of potassium nitrate was 1000 mmol / L).

[0110] Example 26:

[0111] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that alpha rays were used.

[0112] Example 27:

[0113] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that the radiation used was beta radiation.

[0114] Example 28:

[0115] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 3, except that the radiation used was heavy ion radiation.

[0116] Example 29:

[0117] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was lithium nitrate and the amount of lithium nitrate added was 0.1379 g (i.e., the concentration of lithium nitrate was 1000 mmol / L).

[0118] Example 30:

[0119] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was calcium nitrate and the amount of calcium nitrate added was 3.28 g (i.e., the concentration of calcium nitrate was 1000 mmol / L).

[0120] Example 31:

[0121] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was strontium nitrate and the amount of strontium nitrate added was 4.23 g (i.e., the concentration of strontium nitrate was 1000 mmol / L).

[0122] Example 32:

[0123] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was cesium nitrate and the amount of cesium nitrate added was 3.90 g (i.e., the concentration of cesium nitrate was 1000 mmol / L).

[0124] Example 33:

[0125] A nitrate-based three-dimensional gel colorimetric dosimeter was prepared according to the method in Example 5, except that the nitrate was magnesium nitrate and the amount of magnesium nitrate added was 5.13 g (i.e., the concentration of magnesium nitrate was 1000 mmol / L).

[0126] The three-dimensional gel radiotherapy dosimeter prepared by this invention, which uses sodium nitrate as the responsive material, is simple to prepare. The dosimeter has high sensitivity, can detect doses as low as 0.1 Gy, has a fast response speed, and exhibits significant color changes, thus realizing dose visualization.

[0127] For those skilled in the art,

[0128] This gel dosimeter can reach the therapeutic level for detecting high-energy rays in clinical radiotherapy, with a minimum detection limit of 0.1 Gy, higher sensitivity, and faster response speed, making it more suitable for dose detection in clinical radiotherapy.

[0129] This invention proposes a method to reduce nitrate ions to nitrite ions through radiation, which then react with a chromogenic agent to visually change the color of the gel. The color intensity formed in the gel is used as a quantitative report of ionizing radiation, realizing the visualization of dosage. It truly enables real-time observation of the irradiated parts of the human body and the magnitude of the dose received in clinical practice. When applying it to clinical dose verification, the tissue equivalence of the material must be considered. This project uses hydrogel as the base material, and the composition of the hydrogel is very similar to human tissue, resulting in good tissue equivalence.

[0130] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter, comprising the following steps: A. A certain amount of nitrate is dissolved in water to obtain mixed solution I; B. Add a certain amount of hydroxyl shielding agent to mixed solution I, mix well, and obtain mixed solution II; C. Add a certain amount of hydrogel monomer to mixed solution II, mix well, and heat to a certain temperature to obtain mixed solution III; D. Gel dosimeter IV is obtained by physically cross-linking the hydrogel monomers in mixed solution III to form a gel. E. After a certain dose of high-energy radiation has been applied to the surface of the gel dosimeter IV, a certain amount of chromogenic agent is added and left for 5-20 minutes to obtain a color-changing gel. The chromogenic agent on the surface of the gel is then removed, resulting in a color change that gradually deepens with increasing dose.

2. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step A, the nitrate is any one or more of sodium nitrate, potassium nitrate, lithium nitrate, calcium nitrate, strontium nitrate, cesium nitrate, and magnesium nitrate, and the concentration of the nitrate is 0.5 mmol / L to 1000 mmol / L.

3. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: The hydroxyl shielding agent in step B is any one or more of sodium formate, isopropanol, methanol, ethanol, tert-butanol, and sodium sulfite, and the concentration of the hydroxyl shielding agent is 0 mmol / L-1000 mmol / L.

4. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step C, the hydrogel monomer is any one or more of agarose, agar, gelatin, gellan gum, and polyvinyl alcohol, and the heating temperature is 90℃-100℃.

5. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 4, characterized in that: The agarose and agar content is 1%-5% by mass, the gelatin and polyvinyl alcohol content is 10%-15% by mass, and the gellan gum content is 0.05%-0.3% by mass.

6. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step E, the high-energy rays include any one of X-rays, alpha rays, beta rays, gamma rays, electron beams, heavy ions, and protons.

7. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step E, the absorbed dose of the color-changing gel is 0.1 Gy-20 Gy.

8. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step E, the volume ratio of the colorimetric reagent placed on the surface of the gel dosimeter to the volume of the gel dosimeter is 3:1 to 1:

3.

9. The method for preparing a nitrate-based three-dimensional gel colorimetric dosimeter according to claim 1, characterized in that: In step E, the concentration of naphthylethylenediamine hydrochloride in the colorimetric reagent is 1.3 mmol / L-13 mmol / L, sulfonamide is 0.04 mol / L-0.4 mol / L, and phosphoric acid is 3.2 mmol / L-32 mmol / L.

Images