A device and method for detecting the friability of dexamethasone acetate tablets

Abstract

The present application relates to dexamethasone acetate tablet friability detection technical field, specifically disclose a kind of dexamethasone acetate tablet friability detection device, including support mechanism, the turnover mechanism and electrostatic precipitation mechanism of support mechanism top being equipped, the turnover mechanism includes test box assembly, the electrostatic precipitation mechanism includes electrostatic generation assembly and the cathode assembly and anode assembly of electrostatic generation assembly side insertion;The electrostatic generation assembly includes support plate, the top of support plate is equipped with generator;In the present application, through generator to cathode assembly and anode assembly release positive and negative electrode static electricity, and then make test disc dust gather to the top of anode touch plate quickly, compared with artificial cleaning, cleaning is more thorough, and the tablet is dried and dehumidified, and drying is good, different work units are simultaneously used to realize different work contents, the cooperation between the two and mutual support, the detection of dexamethasone acetate tablet friability is realized, stability is high, and operation is simple.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of dexamethasone acetate tablet friability detection, in particular to a dexamethasone acetate tablet friability detection device and method. BACKGROUND

[0002] Dexamethasone acetate tablets are a kind of drug for treating allergic and autoimmune inflammatory diseases. The tablets may be subjected to internal vibration, friction, collision and other factors during transportation or handling, which may cause the tablets to be broken or fragmented. Therefore, in order to detect the anti-wear and anti-shock capability, the friability of the tablets needs to be detected. In the prior art, a friability detection device is usually used to detect the friability of the tablets. This device can meet the general requirements, but it still has the following shortcomings in actual use:

[0003] In the prior art, the surface of the tablets needs to be manually blown and cleaned before and after detection. When the tablets are small, the tablets are easily blown away, and manual control can easily contaminate the surface of the tablets.

[0004] In the prior art, the inside of the tablet rotating cavity of the detection device needs to be manually cleaned twice before and after detection. The dust of the tablets is difficult to clean at the corners of the rotating cavity, which increases the workload of tablet friability detection.

[0005] Furthermore, the existing tablet friability detection device lacks a drying and dehumidifying device. When the tablets are wet, it not only affects the detection result of the friability, but also contaminates the inside of the detection device, thereby affecting the subsequent normal detection. SUMMARY

[0006] The purpose of the present application is to provide a dexamethasone acetate tablet friability detection device to solve the problems in the background art.

[0007] To achieve the above purpose, the present application provides the following technical scheme: a dexamethasone acetate tablet friability detection device, comprising a support mechanism, a turnover mechanism and an electrostatic dust removal mechanism provided on the top of the support mechanism, the turnover mechanism comprising a test box assembly, the electrostatic dust removal mechanism comprising an electrostatic generator assembly and a cathode assembly and an anode assembly inserted on the side of the electrostatic generator assembly.

[0008] The electrostatic generator assembly comprises a support plate, and a power generator is arranged on the top of the support plate.

[0009] The test box assembly comprises a back plate, a test disc is rotatably connected to the side of the back plate away from the power generator through a bearing, an anode contact plate is arranged on the bottom of the test disc through a plug-in assembly, a cathode contact plate is arranged on the inner wall of the back plate, and a resistance heater is arranged on the inner wall of the back plate.

[0010] The cathode assembly comprises a cathode rod inserted with the generator side, the output end of the cathode rod is inserted into the back plate and provided with a first single-pole double-throw switch, one end of the first single-pole double-throw switch is electrically connected with the cathode contact plate through a conductive wire, and the other end of the first single-pole double-throw switch is electrically connected with the resistance heater through a conductive wire.

[0011] The anode assembly comprises an anode plate inserted with the generator side, the output end of the anode plate is inserted into the back plate and provided with a second single-pole double-throw switch, one end of the second single-pole double-throw switch is electrically connected with the anode contact plate through a conductive wire, and the other end of the second single-pole double-throw switch is electrically connected with the resistance heater through a conductive wire.

[0012] Preferably, the insertion assembly comprises a drop slot, the drop slot is opened in the bottom of the test disc, a sealing plate is inserted into the slot body of the drop slot, the anode contact plate is fixedly connected to the middle of the sealing plate, and an electrode seat is arranged on one side of the sealing plate and is electrically connected with the conductive wire.

[0013] Preferably, the support mechanism comprises a middle support assembly, side support assemblies arranged at the left and right ends of the middle support assembly, and sliding drive assemblies arranged on the side surfaces of the side support assemblies, the turnover mechanism further comprises a turnover assembly arranged on the top of the middle support assembly and a control assembly arranged at the front end of the turnover assembly.

[0014] Preferably, the middle support assembly comprises a middle plate, an electronic weighing plate is arranged on the top of the middle plate, the turnover assembly is fixedly installed on the top of the electronic weighing plate, the side support assembly comprises a side plate, guide rails are symmetrically arranged on the top of the side plate, and a driving plate is arranged on the outer end surface of the side plate.

[0015] Preferably, the sliding drive assembly comprises a drive cylinder fixedly installed on the outer side surface of the driving plate, a connecting plate is arranged at the end of the piston rod of the drive cylinder and on the inner side of the driving plate, the bottom of the support plate is slidably connected with the guide rail, and the side surface of the support plate is fixedly connected with the connecting plate.

[0016] Preferably, the turnover assembly comprises a turnover box in a box structure, a bottom plate is arranged on the bottom of the turnover box, the bottom plate is fixedly installed on the top of the electronic weighing plate, a driving motor is arranged in the middle of the turnover box, and the rotating shaft of the driving motor penetrates through the left and right end walls of the turnover box.

[0017] Preferably, the control assembly comprises a mounting plate engaged with the front end of the turnover box, a touch screen is arranged on the front end of the mounting plate, and the touch screen is electrically connected with the driving motor.

[0018] Preferably, the middle of the test disc is provided with a rotating sleeve which is sleeved with the main shaft of the driving motor, the inner wall of the test disc is uniformly provided with a plurality of dial teeth, and the inner wall of the test disc is provided with a circular arc structure of the turnover arc plate, and the inner wall of the test disc is uniformly provided with a plurality of medicine leakage holes.

[0019] Preferably, the inner wall of the back plate is uniformly provided with a plurality of exhaust holes, the inner wall of the back plate is embedded with a cathode emission ring, the cathode contact plate is connected with the cathode emission ring through a guide strip, the outer side of the cathode rod is wrapped with a first sheath, the outer side of the anode plate is wrapped with a second sheath, and the other side of the second sheath is provided with a drag seat.

[0020] A dexamethasone acetate tablet friability detection method, the method relates to a dexamethasone acetate tablet friability detection device for detecting the friability of dexamethasone acetate tablets, and the method specifically comprises the following steps:

[0021] Step one, preparation, prepare a plurality of dexamethasone acetate tablets to be detected;

[0022] Step two, cleaning and counting, the touch screen controls the main shaft of the driving motor to rotate by 45 degrees, then the sealing plate at the bottom of the test disc is pulled out, the prepared dexamethasone acetate tablets are placed into the test disc from the port of the feeding groove, the sealing plate is inserted back to the original position, the cathode discharge of the generator is started, and the discharge time is controlled to be 10 seconds, the cathode discharge of the generator is turned off, the anode discharge of the generator is started, and the discharge time is controlled to be 12 seconds, then the generator is turned off, the driving motor is rotated by 45 degrees and turned off, the sealing plate is pulled out, the surface of the sealing plate is cleaned by external force, after completion, the sealing plate is inserted back to the original position, and the weight data displayed by the touch screen at this time is recorded;

[0023] Step three, heating and dehumidifying, the touch screen controls the generator to start and respectively input negative current and positive current into the cathode rod and the anode plate, the first single-pole double-throw switch and the second single-pole double-throw switch are connected with the resistance heater, and the resistance heater generates heat when started;

[0024] Step four, rotation counting, the rotation speed and rotation time of the driving motor are set through the touch screen, so that the rotation number is controlled to be 100, then the driving motor is started to drive the test box assembly to rotate, and the rotation is stopped after 100 rotations;

[0025] Step five, cathode power on, start the cathode power of the power generator, and connect the first single pole double throw switch with the corresponding conductive wire of the cathode touch plate, and then connect the cathode rod, cathode touch plate, guide strip and cathode emission ring, discharge the cathode in the test disc, release the static ions to make the dust and debris in the test disc carry anions, and turn off the power generator after 10 seconds of power on;

[0026] Step six, anode power on, start the anode power of the power generator, and connect the second single pole double throw switch with the corresponding conductive wire of the anode touch plate, connect the anode plate and the anode touch plate, make the anode touch plate carry positive ions, and then adsorb all the dust and debris carrying negative ions in the test disc to the anode touch plate, and turn off the power generator after 12 seconds of power on;

[0027] Step seven, secondary cleaning count, 5 seconds after the power generator is turned off, start the driving motor to rotate 45 degrees, turn off the driving motor, pull out the sealing plate from the bottom of the test disc, blow the sealing plate clean and then insert it back to the original position, start the driving motor to rotate back to the original position, and record the weight data displayed by the touch screen at this time.

[0028] Compared with the prior art, the beneficial effects of the present application are:

[0029] 1. In the present application, the dust in the test disc is adsorbed to the top of the anode touch plate, and then the dust carried on the surface of the test disc is quickly cleaned to the top of the anode touch plate, realizing the quick cleaning of the dust on the test disc before and after the experiment, which is more efficient than manual cleaning and avoids contamination of the test disc.

[0030] 2. In the present application, the dust and debris generated by the broken test disc are quickly cleaned, which is more thorough and efficient than manual cleaning.

[0031] 3. In the present application, the detection accuracy is high, the detection quality is good, and the test disc is dried and dehumidified, which is good in drying property, and the dust and debris before and after the test disc detection can be effectively removed, avoiding affecting the detection data, and different working units are used to realize different working contents, which are coordinated and supported with each other, and together realize the detection of the brittleness of dexamethasone acetate tablets, which is high in stability and simple in operation. BRIEF DESCRIPTION OF DRAWINGS

[0032] Figure 1 It is the overall structure of the present application from the axial side view;

[0033] Figure 2 It is the overall structure of the present application from the front view;

[0034] Figure 3 It is Figure 2 the cross-sectional structure of A-A from the axial side view;

[0035] Figure 4 For Figure 2 Structure axial view of section at B-B;

[0036] Figure 5 For Figure 2 Structure axial view of section at C-C;

[0037] Figure 6 For Figure 2 Structure axial view of section at D-D;

[0038] Figure 7 Left view of overall structure of the application;

[0039] Figure 8 For Figure 7 Structure axial view of section at F-F;

[0040] Figure 9 For Figure 8 Enlarged schematic view of partial structure at E;

[0041] Figure 10 Circuit diagram in the application.

[0042] In the figure: 1, intermediate support assembly; 2, side support assembly; 3, sliding drive assembly; 4, turnover assembly; 5, test box assembly; 6, control assembly; 7, static electricity generating assembly; 8, cathode assembly; 9, anode assembly; 101, intermediate plate; 102, electronic weighing plate; 201, side plate; 202, guide rail; 203, drive plate; 301, drive cylinder; 302, connecting plate; 401, turnover box; 402, bottom plate; 403, drive motor; 501, test disc; 502, rotating sleeve; 503, dial teeth; 504, turnover arc plate; 505, dropping groove; 506, sealing plate; 507, anode contact plate; 508, cathode contact plate; 509, guide strip; 510, cathode emission ring; 511, exhaust hole; 512, back plate; 513, medicine leakage hole; 601, mounting plate; 602, touch screen; 701, support plate; 702, power generator; 801, cathode rod; 802, first sheath; 805, first single-pole double-throw switch; 806, conductive wire; 807, resistance heater; 901, anode plate; 902, second sheath; 903, drag seat; 905, second single-pole double-throw switch. DETAILED DESCRIPTION

[0043] With reference to the drawings of the embodiments of the present application, the technical solutions in the embodiments of the present application will be described clearly and completely. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0044] Please refer to Figures 1 to 10 The present application provides a technical solution: a dexamethasone acetate tablet friability detection device, comprising a support mechanism, a turnover mechanism and an electrostatic dust removal mechanism provided on the top of the support mechanism, the support mechanism comprising a middle support assembly 1, side support assemblies 2 provided on the left and right ends of the middle support assembly 1, and sliding drive assemblies 3 provided on the side surfaces of the side support assemblies 2, the turnover mechanism comprising a test box assembly 5, the turnover mechanism further comprising a turnover assembly 4 provided on the top of the middle support assembly 1 and a control assembly 6 provided on the front end of the turnover assembly 4, the test box assembly 5 being symmetrically arranged on the left and right ends of the turnover assembly 4, the electrostatic dust removal mechanism comprising an electrostatic generation assembly 7 slidably fitted on the top of the side support assembly 2, a cathode assembly 8 and an anode assembly 9 insertedly fitted on the side surfaces of the electrostatic generation assembly 7.

[0045] The middle support assembly 1 comprises a middle plate 101, and an electronic weighing plate 102 is provided on the top of the middle plate 101, and the turnover assembly 4 is fixedly installed on the top of the electronic weighing plate 102. Here, the electronic weighing plate 102 is an electronic weighing device, and the electronic weighing plate 102 is electrically connected with the touch screen 602, so that the data measured by the electronic weighing plate 102 can be fed back on the screen of the touch screen 602 in real time.

[0046] The side support assembly 2 comprises a side plate 201, and guide rails 202 are symmetrically provided on the top of the side plate 201, the bottom of the electrostatic generation assembly 7 is slidably fitted with the guide rails 202, and a drive plate 203 is provided on the outer end surface of the side plate 201. Here, the guide rails 202 have a guiding and supporting effect on the electrostatic generation assembly 7.

[0047] The sliding drive assembly 3 comprises a drive cylinder 301 fixedly installed on the outer side surface of the drive plate 203, and a connecting plate 302 is provided on the end of the piston rod of the drive cylinder 301 and on the inner side of the drive plate 203. Here, the drive plate 203 has a supporting effect on the drive cylinder 301.

[0048] The electrostatic generation assembly 7 comprises a support plate 701, and a power generator 702 is provided on the top of the support plate 701, the bottom of the support plate 701 is slidably fitted with the guide rails 202, and the side surface of the support plate 701 is fixedly connected with the connecting plate 302. When working, the drive cylinder 301 is started to drive the piston rod to drive the connecting plate 302 and the support plate 701 to move up and down, so that the support plate 701 moves left and right along the guide rails 202.

[0049] The turnover assembly 4 comprises a turnover box 401 of a box structure, and a bottom plate 402 is arranged at the bottom of the turnover box 401 and fixedly installed on the top of the electronic weighing plate 102. A driving motor 403 is arranged in the middle of the turnover box 401, and the rotating shaft of the driving motor 403 is in penetrating fit with the left and right end walls of the turnover box 401. Here, the driving motor 403 plays a role of rotary driving relative to the test box assembly 5.

[0050] The control assembly 6 comprises a mounting plate 601 which is buckled with the front end of the turnover box 401, and a touch screen 602 is arranged at the front end of the mounting plate 601 and electrically connected with the driving motor 403. The on-off, rotation speed and working time of the driving motor 403 are controlled through the touch screen 602, so as to realize the control of the rotation number of the driving motor 403.

[0051] The test box assembly 5 comprises a back plate 512, and a test disc 501 is rotatably connected to the side of the back plate 512 away from the power generator 702 through a bearing. The back plate 512 does not rotate in actual use. A plurality of exhaust holes 511 are uniformly arranged on the inner wall of the back plate 512, and the exhaust holes 511 are used for discharging water vapor in the medicine, especially the dust impurities in the water vapor, so as to effectively improve the cleaning and drying degree of the medicine. A rotating sleeve 502 is arranged in the middle of the test disc 501, and the rotating sleeve 502 is in sleeved fit with the main shaft of the driving motor 403. A plurality of dial teeth 503 are uniformly arranged on the inner circle of the test disc 501. An arc-shaped turnover arc plate 504 is led from the rotating sleeve 502 to the inner wall of the test disc 501, and a plurality of medicine leakage holes 513 are uniformly arranged in the turnover arc plate 504. The output end of the driving motor 403 drives the turnover arc plate 504 to rotate. When the turnover arc plate 504 rotates, the test disc 501 is driven to rotate around the back plate 512 through the clamping of the dial teeth 503, so as to stir the tablets in the test disc 501 and test the friability of the tablets in the test disc 501 through the dial teeth 503. The tablets carried by the dial teeth 503 and the turnover arc plate 504 are discharged along the medicine leakage holes 513, so as to avoid the damage of the tablets caused by being carried too high. A resistance heater 807 is arranged on the lower part of the inner wall of the back plate 512. The resistance heater 807 generates heat when working, so as to heat and dehumidify the tablets in the test disc 501, and avoid the reduction of the detection accuracy of the friability of the tablets caused by moisture.

[0052] The bottom of the test disc 501 is provided with an anode contact plate 507 through a plug-in assembly, the plug-in assembly comprises a drop slot 505 which is opened in the bottom of the test disc 501, and a sealing plate 506 is inserted into the slot body of the drop slot 505, the sealing plate 506 can be pulled out or inserted along the drop slot 505 to realize the feeding and discharging of the tablets in the test disc 501, the anode contact plate 507 is fixedly connected to the middle of the sealing plate 506, the anode contact plate 507 is mainly used for releasing positive electricity, so as to adsorb and recover the dust impurities with negative ions adsorbed in the test disc 501, one side of the sealing plate 506 is provided with an electrode seat which is electrically connected with the conductive wire 806, so as to ensure that when the sealing plate 506 is inserted into the drop slot 505 and the sealing plate 506 is rotated to the bottom of the test disc 501, the positive current from the outside can be transmitted to the anode contact plate 507 through the electrode seat to emit positive electricity.

[0053] The inner wall of the back plate 512 is provided with a cathode contact plate 508, and a cathode emission ring 510 is embedded in the inner wall of the back plate 512 in a ring shape, the cathode contact plate 508 and the cathode emission ring 510 are connected through a guide strip 509, in working, the driving motor 403 drives the test disc 501 to rotate, so that the tablets in the test disc 501 are turned over at a set rotating speed and rotating number, the tablets in the test disc 501 rub against each other during the turning over process, and before and after the rotation is completed, the turning over assembly 4, the test box assembly 5 and the control assembly 6 as a whole will display a certain value on the touch screen 602 through the electronic weighing plate 102, and the friability of the tablets can be determined by comparing the values of the two.

[0054] The cathode assembly 8 comprises a cathode rod 801 which is plugged with the side of the power generator 702, the outer side of the cathode rod 801 is wrapped with a first sheath 802, the output end of the cathode rod 801 is inserted into the inside of the back plate 512 and is provided with a first single-pole double-throw switch 805, the first single-pole double-throw switch 805 functions as a control switch, one end of the first single-pole double-throw switch 805 is electrically connected with the cathode contact plate 508 through the conductive wire 806, the other end of the first single-pole double-throw switch 805 is electrically connected with the resistance heater 807 through the conductive wire 806, when the conductive wire 806 corresponding to the first single-pole double-throw switch 805 and the cathode contact plate 508 is in communication, the cathode contact plate 508 is connected through the guide strip 509 and emits cathode ions to the cathode emission ring 510, so that the impurities and dust in the test disc 501 or the broken tablets carry negative ions, which is convenient for recycling and cleaning in the later stage, when the conductive wire 806 corresponding to the other end of the first single-pole double-throw switch 805 and the resistance heater 807 is in communication, the resistance heater 807 is provided with current by the anode assembly 9 to generate heat.

[0055] The anode assembly 9 comprises an anode plate 901 which is inserted into the side of the power generator 702, the outer side of the anode plate 901 is wrapped with a second sheath 902, the other side of the second sheath 902 is provided with a socket 903, the output end of the anode plate 901 is inserted into the back plate 512 and is provided with a second single-pole double-throw switch 905, one end of the second single-pole double-throw switch 905 is electrically connected with the anode contact plate 507 through the conductive wire 806, the other end of the second single-pole double-throw switch 905 is electrically connected with the resistance heater 807 through the conductive wire 806, similarly, when the second single-pole double-throw switch 905 is in communication with the conductive wire 806 corresponding to the anode contact plate 507, the top of the sealing plate 506 carries positive electricity, then the impurities dust or broken tablets in the test disc 501 which carry negative ions can be adsorbed and fixed, and then it is convenient for recycling and cleaning in the later period; when the second single-pole double-throw switch 905 is in communication with the conductive wire 806 corresponding to the other end of the resistance heater 807, the resistance heater 807 is provided with current to generate heat in cooperation with the cathode rod 801.

[0056] In use, first prepare a certain amount of dexamethasone acetate tablets, for example, prepare 20 dexamethasone acetate tablets to be detected, then the touch screen 602 first controls the driving cylinder 301 to start and drive the connecting plate 302 to move to the appropriate position, the connecting plate 302 moves synchronously to drive the supporting plate 701 to move to the appropriate position, and the corresponding power generator 702 moves to the appropriate position to supply power.

[0057] Then the touch screen 602 controls the driving motor 403 to start and rotate 45 degrees, at this time the rotating sleeve 502 drives the turnover arc plate 504 to rotate 45 degrees, and the turnover arc plate 504 drives the test disc 501 to rotate 45 degrees around the back plate 512 to reach the appropriate position through the end and the dial gear 503, thereby facilitating the removal of the sealing plate 506, then the sealing plate 506 is pulled out along the feeding groove 505, the dexamethasone acetate tablets to be detected are put into the test disc 501 along the feeding groove 505, and the sealing plate 506 is inserted back, then the touch screen 602 controls the driving motor 403 to reverse 45 degrees to restore to the original position.

[0058] The touch screen 602 controls the power generator 702 to start the cathode discharge, the power generator 702 inputs negative current to the cathode rod 801, and the touch screen 602 controls the first single-pole double-throw switch 805 to be in communication with the conductive wire 806 corresponding to the cathode contact plate 508, at this time the negative current in the cathode rod 801 flows into the cathode contact plate 508 along the conductive wire 806, and flows into the cathode emission ring 510 along the cathode contact plate 508 and the guide strip 509, and emits negative ions into the test disc 501 by means of the cathode emission ring 510, thereby making the dust impurities in the test disc 501 and the impurities attached to the surface of the tablets carry negative ions, specifically after being turned on for 10 seconds, the touch screen 602 controls the power generator 702 to stop inputting negative current to the cathode rod 801.

[0059] Then, the touch screen 602 controls the generator 702 to supply positive current to the anode plate 901, and the touch screen 602 controls the second single-pole double-throw switch 905 to connect with the corresponding conductive line 806 of the anode contact plate 507. At this time, the positive current in the anode plate 901 flows to the anode contact plate 507 through the electrode seat. The anode contact plate 507 performs anode discharge and adsorbs and fixes the dust and impurities with anions inside the test plate 501, thereby ensuring that the dust and impurities are adsorbed on the surface of the sealing plate 506. Specifically, after 12 seconds of activation, the touch screen 602 controls the generator 702 to stop supplying positive current to the anode plate 901.

[0060] After completing this task, the touch screen 602 restarts the drive motor 403 to rotate forward. The drive motor 403 drives the test tray 501 to rotate 45 degrees through the rotating sleeve 502, and then pulls out the sealing plate 506 along the feeding slot 505. As the tablets in the test tray 501 fall to the bottom of the test tray 501 through the leakage hole 513 under their own gravity, the tablets will not be lost. The external force is used to remove the dust and impurities attached to the surface of the sealing plate 506 after it is pulled out, which further improves the stability and efficiency of the friability test of dexamethasone acetate tablets, ensures an absolutely clean and dust-free environment inside the test tray 501, and avoids unnecessary impact on subsequent tests.

[0061] After the inside of the test disc 501 is cleaned, the sealing plate 506 is inserted back. At this time, the touch screen 602 controls the drive motor 403 to start and drive the test disc 501 to rotate through the rotating sleeve 502. Specifically, it rotates 100 times. When the test disc 501 rotates, the tablets inside the test disc 501 are lifted and broken by the cooperation of the flipping arc plate 504 and the dial tooth 503, which further improves the detection and adjustment of the brittleness of dexamethasone acetate tablets. When the tablets rotate with the test disc 501, they fall along the leakage hole 513 under their own gravity, thus ensuring that the tablets are always in the lower half of the test disc 501.

[0062] When the test disc 501 rotates, the touch screen 602 controls the generator 702 to start, and the generator 702 supplies corresponding positive and negative currents to the cathode rod 801 and the anode plate 901, and the touch screen 602 controls the first single-pole double-throw switch 805 and the second single-pole double-throw switch 905 to be connected to the resistance heater 807, at this time, the resistance heater 807 is connected to the current to start working and generate heat, which heats and dries the tablets in the test disc 501, further ensuring that the moisture in the tablets is quickly evaporated into water vapor, which carries the broken tablet powder in the test disc 501 when moving to the top of the test disc 501, and is eventually discharged along the exhaust hole 511, so that the resistance heater 807 not only effectively realizes the drying and dehumidifying effect of the tablets in the test disc 501, but also absorbs and discharges the powder generated after the tablets are broken, and effectively avoids the influence of the tablet powder adsorbed to the inner wall of the test disc 501 on the subsequent work.

[0063] When the test disc 501 completes the rotation work, the touch screen 602 controls the driving motor 403 to stop working and return to the original position, at this time, the touch screen 602 controls the generator 702 to supply negative current to the cathode rod 801, and stops supplying power to the anode plate 901, the touch screen 602 controls the first single-pole double-throw switch 805 to be connected to the cathode plate 508, as known from the above, the negative current in the cathode rod 801 flows into the cathode emission ring 510 along the cathode plate 508 and the guide strip 509, and emits anions into the test disc 501 by the cathode emission ring 510, which adsorbs the tablet powder or dust debris in the test disc 501, carries the anions, and after completion, the touch screen 602 controls the generator 702 to stop supplying negative current to the cathode rod 801, and the generator 702 supplies positive current to the anode plate 901, and the touch screen 602 controls the second single-pole double-throw switch 905 to be connected to the anode plate 507, then the positive current in the anode plate 901 flows through the electrode seat to the anode plate 507, so that the top of the sealing plate 506 has positive electricity, which adsorbs the dust debris with anions in the test disc 501 to the top of the sealing plate 506, after adsorption, the touch screen 602 controls the generator 702 to stop working, the driving motor 403 starts to drive the test disc 501 to rotate by 45 degrees, the sealing plate 506 is pulled out and the sealing plate 506 is removed by external force, after completion, the tablet falls to the bottom of the test disc 501 under the action of gravity, and the weight of the tablet is measured by the electronic weighing plate 102, and the friability of the tablet is obtained.

[0064] Especially, in the process of dust and debris adsorption and impurity removal of the tablets, the resistance heater 807 does not work, at this time, the influence of water vapor generated by heating of the tablets on the generation and adsorption of anions is effectively avoided, thereby reducing the efficiency and stability of the dust and debris impurity removal in the tablets, and the problem of inconvenient extraction of the sealing plate 506 in the test disc 501 due to excessive temperature is avoided, so the two circuits work with the same power generation unit generator 702, but different working units realize different working contents in actual work, and at the same time, they are coordinated and mutually supported, and together realize the detection of the brittleness of dexamethasone acetate tablets, the detection precision is higher, and the detection quality is better.

[0065] The device has high detection precision and good detection quality, can dry and dehumidify the tablets, has good dryness, can effectively remove dust and debris before and after tablet detection, avoids affecting the detection data, realizes different working contents with different working units, and is coordinated and mutually supported, together realizes the detection of the brittleness of dexamethasone acetate tablets, has high stability, and is simple to operate.

[0066] Second embodiment

[0067] The application also relates to a dexamethasone acetate tablet brittleness detection method, which is used for detecting the brittleness of dexamethasone acetate tablets and comprises the following steps:

[0068] Step one, material preparation, 20 dexamethasone acetate tablets to be detected are prepared;

[0069] Step two, cleaning and counting, the main shaft of the driving motor 403 is controlled to rotate by 45 degrees through the touch screen 602, the sealing plate 506 is extracted from the bottom of the test disc 501, the prepared dexamethasone acetate tablets are placed into the test disc 501 from the port of the feeding groove 505, the sealing plate 506 is inserted back to the original position, the driving motor 403 is controlled to rotate reversely by 45 degrees to the original position, the cathode discharge of the power generator 702 is started, the discharge time is controlled to be 10 seconds, the cathode discharge of the power generator 702 is turned off, the anode discharge of the power generator 702 is started, the discharge time is controlled to be 12 seconds, then the power generator 702 is turned off, the driving motor 403 is started to rotate by 45 degrees and then turned off, the sealing plate 506 is extracted, the surface of the sealing plate 506 is cleaned by external force, after the cleaning, the sealing plate 506 is inserted back to the original position, and the weight data displayed by the touch screen 602 at this time is recorded;

[0070] Step three, heating and dehumidification, the power generator 702 is started and negative current and positive current are respectively input into the cathode rod 801 and the anode plate 901 through the touch screen 602, the first single-pole double-throw switch 805 and the second single-pole double-throw switch 905 are connected with the resistance heater 807, and the resistance heater 807 generates heat when being started;

[0071] Step four, rotation count, set the rotation speed and rotation time of the driving motor 403 through the touch screen 602, so that the rotation count is controlled at 100, start the driving motor 403 to drive the test box assembly 5 to rotate, and stop rotating after rotating 100 times;

[0072] Step five, cathode power-on, start the cathode power-on of the generator 702, and then connect the cathode rod 801, the cathode contact plate 508, the guide strip 509 and the cathode emission ring 510, discharge the cathode in the test disc 501 to release the static ions, so that the dust and debris in the test disc 501 carry anions, and turn off the generator 702 after 10 seconds of power-on;

[0073] Step six, anode power-on, start the anode power-on of the generator 702, and then connect the anode plate 901 and the anode contact plate 507, so that the anode contact plate 507 carries positive ions, and then adsorb the dust and debris carrying anions in the test disc 501 to the anode contact plate 507, and turn off the generator 702 after 12 seconds of power-on;

[0074] Step seven, secondary cleaning count, 5 seconds after the generator 702 is turned off in step six, start the driving motor 403 to rotate 45 degrees, turn off the driving motor 403, pull out the sealing plate 506 from the bottom of the test disc 501, blow the sealing plate 506 clean and then insert it back to the original position, start the driving motor 403 to rotate back to the original position, and record the weight data displayed by the touch screen 602 at this time.

[0075] Although the embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A dexamethasone acetate tablet friability testing device, characterized by: Including support mechanism, the turnover mechanism that the top of support mechanism is equipped with and the electrostatic dust removal mechanism, the turnover mechanism includes test box subassembly, the electrostatic dust removal mechanism includes electrostatic generation subassembly and the cathode subassembly and anode subassembly that electrostatic generation subassembly side is inserted with, The electrostatic generation subassembly includes support plate, and the top of support plate is equipped with power generator; The test box subassembly includes backboard, and the side away from power generator of backboard is rotatably connected with test disc through bearing, and the bottom of test disc is equipped with anode contact plate through plug-in assembly, and the inner wall of backboard upper portion is equipped with cathode contact plate, and the inner wall of backboard lower portion is equipped with resistance heater; The cathode subassembly includes cathode rod that is inserted with the side of power generator, and the output end of cathode rod is inserted into the inside of backboard and is equipped with first single-pole double-throw switch, and one end of first single-pole double-throw switch is electrically connected with cathode contact plate through conducting wire, and the other end of first single-pole double-throw switch is electrically connected with resistance heater through conducting wire; The anode subassembly includes anode plate that is inserted with the side of power generator, and the output end of anode plate is inserted into the inside of backboard and is equipped with second single-pole double-throw switch, and one end of second single-pole double-throw switch is electrically connected with anode contact plate through conducting wire, and the other end of second single-pole double-throw switch is electrically connected with resistance heater through conducting wire; The plug-in assembly includes drop slot, and the drop slot is opened in the bottom of test disc, and the slot body of drop slot is inserted with sealing plate, and anode contact plate is fixedly connected to the middle of sealing plate, and one side of sealing plate is equipped with electrode seat that is electrically connected with conducting wire; The middle of test disc is equipped with rotating sleeve, and the inner ring of test disc is uniformly distributed with multiple groups of dial teeth, and the inner wall of test disc is led to turnover arc plate of circular arc structure from rotating sleeve, and the inside of turnover arc plate is uniformly arrayed with multiple groups of medicine leakage holes; The inner wall of backboard is uniformly arrayed with multiple groups of exhaust holes, and backboard inner wall is ring-shapedly embedded with cathode emission ring, and cathode contact plate and cathode emission ring middle are connected through guide strip, and the outside of cathode rod is wrapped with first sheath, and the outside of anode plate is wrapped with second sheath, and the other side of second sheath is equipped with drag seat.

2. The apparatus for detecting friability of dexamethasone acetate tablets according to claim 1, characterized by: The support mechanism includes middle support assembly, side support assembly that is equipped with on the left and right two ends of middle support assembly and sliding drive assembly that is equipped with on the side of side support assembly, and the turnover mechanism further includes turnover assembly that is equipped with on the top of middle support assembly and control assembly that is equipped with on the front end of turnover assembly.

3. The apparatus for detecting the friability of dexamethasone acetate tablets according to claim 2, characterized by: The middle support assembly includes middle plate, and the top of middle plate is equipped with electronic weighing plate, and the top of electronic weighing plate is fixedly installed with turnover assembly, and the top of side plate is symmetrically equipped with guide rail, and the outer side end surface of side plate is equipped with driving plate.

4. The apparatus for detecting the friability of dexamethasone acetate tablets according to claim 3, characterized by: The sliding drive assembly includes driving cylinder that is fixedly installed on the outer side surface of driving plate, and connecting plate is equipped on the end of driving cylinder piston rod and on the inner side of driving plate, and the bottom of support plate is slidably matched with guide rail, and the side of support plate is fixedly connected with connecting plate.

5. The apparatus for detecting the friability of dexamethasone acetate tablets according to claim 3, characterized by: The turnover assembly comprises a turnover box of a box structure, and a bottom plate is arranged at the bottom of the turnover box and fixedly installed at the top of the electronic weighing plate.

6. A device for detecting the friability of dexamethasone acetate tablets according to claim 5, characterized in that: The control assembly comprises an installation plate engaged with the front end of the turnover box, and a touch screen is arranged at the front end of the installation plate and electrically connected with the driving motor.

7. A device for detecting the friability of dexamethasone acetate tablets according to claim 5, characterized in that: The rotating sleeve is sleeved with the main shaft of the driving motor.

8. A method for detecting friability of dexamethasone acetate tablets, the method involving the use of a dexamethasone acetate tablet friability detection device as claimed in claim 6 for detecting friability of dexamethasone acetate tablets, characterized in that: The method specifically comprises the following steps: Step one, preparation, prepare multiple dexamethasone acetate tablets to be detected; Step two, cleaning and counting, the touch screen controls the main shaft of the driving motor to rotate by 45 degrees, then the sealing plate at the bottom of the test disc is pulled out, the prepared dexamethasone acetate tablets are placed into the test disc from the feeding groove port, the sealing plate is inserted back to the original position, the cathode discharge of the generator is started, the discharge time is controlled for 10 seconds, the anode discharge of the generator is started, the discharge time is controlled for 12 seconds, then the generator is stopped, the driving motor is started to rotate by 45 degrees and stopped, the sealing plate is pulled out, the surface of the sealing plate is cleaned by external force, then the sealing plate is inserted back to the original position, and the weight data displayed by the touch screen at this time is recorded; Step three, heating and dehumidifying, the generator is started and negative current and positive current are respectively input into the cathode rod and the anode plate, the first single-pole double-throw switch and the second single-pole double-throw switch are both connected with the resistance heater, and the resistance heater generates heat when started; Step four, rotating and counting, the rotating speed and rotating time of the driving motor are set through the touch screen, so that the rotating number is controlled within 100, then the driving motor is started to rotate, and the test box assembly is rotated by the main shaft, and the rotation is stopped after 100 rotations; Step five, cathode electrification, the cathode electrification of the generator is started, the first single-pole double-throw switch is connected with the conductive wire corresponding to the cathode contact plate, then the cathode rod, the cathode contact plate, the guide strip and the cathode emission ring are connected, the test disc is discharged by the cathode, the dust and debris in the test disc are all carried by the negative ions, the generator is stopped after 10 seconds of electrification; Step six, anode electrification, the anode electrification of the generator is started, the second single-pole double-throw switch is connected with the conductive wire corresponding to the anode contact plate, the anode plate and the anode contact plate are connected, the anode contact plate carries the positive ion static electricity, then the dust and debris in the test disc carrying the negative ions are all adsorbed on the anode contact plate, and the generator is stopped after 12 seconds of electrification; Step seven, secondary cleaning and counting, 5 seconds after the generator is stopped, the driving motor is started to rotate by 45 degrees, the driving motor is stopped, the sealing plate is pulled out from the bottom of the test disc, the sealing plate is blown clean and then inserted back to the original position, the driving motor is started to rotate back to the original position, and the weight data displayed by the touch screen at this time is recorded.

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