Sealed box for plastic ampoule

Abstract

The present invention relates to the field of medicines, and in particular to a sealed box for plastic ampoules, comprising a plurality of back panels and a plurality of ampoule chambers, wherein the back panels are of an integrated structure, folds are provided at the connection between adjacent back panels, the ampoule chambers are rectangular concave chambers with fixed eaves provided at their edges, an indicator tube and a colorimetric card are provided on the front surface of the ampoule chambers, the outer surface of the ampoule chambers and the front surface of the back panels are covered with aluminum foil, the fixed eaves are detachably fixedly connected to the back panel by a sealing strip, and the back panel and the ampoule chambers are combined into a sealed box; the present invention utilizes the airtightness of the aluminum foil to isolate the sealed box from oxygen, thereby creating an anaerobic storage environment for the ampoules, and preventing oxygen from penetrating into the medicines through the plastic bottles of the ampoules and causing the medicines to oxidize and expire; by comparing the indicator and the colorimetric card, the time when the ampoule bottles are taken out is judged, and the shelf life of the medicines is auxiliary inferred; and by providing an antioxidant coating on the front surface of the back panel, unused medicines can be put back into the sealed box and an anaerobic storage environment can be recreated.

Description

Technical Field

[0001] The invention relates to the field of medicines, in particular to a sealing box for plastic ampoules. Background Art

[0002] Currently, ampoules are mainly divided into glass ampoules and plastic ampoules. Glass ampoules are prone to produce glass shards during the process of breaking the nipple, while plastic ampoules can avoid this problem. However, plastic ampoules have a relatively high oxygen permeability due to their own material properties. After oxygen penetrates through the bottle body of the plastic ampoule and enters the bottle, it will come into contact with the medicine in the bottle. For some medicines, it will be oxidized and expire. Currently, plastic ampoules are generally stored in paper or plastic storage boxes. For the problem of oxygen permeability of plastic ampoules, existing packaging technology has not made targeted designs to solve this problem.

[0003] Regarding the oxygen permeability of plastics, an article published in the journal "China Plastics" entitled "Research on the Pressure Difference Method for Testing the Oxygen Permeability of Plastic Pipes" (Article Number: 1001-9278(2021)01-0073-05) shows that plastic materials with different structures all have a certain degree of oxygen permeability.

[0004] As for the permeation of oxygen in ampoules, an oxygen indicator needs to be added to the dark sealed box to observe the specific oxygen permeation situation. For this, Chinese invention patent CN106841187B (publication date: 2019-06-04) discloses a rapid liquid oxygen indicator and its preparation method and application. This oxygen indicator includes Reactive Black 5, Klebsiella pneumoniae strain KL1, liquid culture medium and distilled water. It can be used for oxygen detection in sealed food storage environments, medical oxygen-free environments, anaerobic bacteria culture environments and other oxygen-free operating environments to detect the presence of oxygen and determine the oxygen concentration.

[0005] To prevent the oxidation of drugs, Chinese invention patent CN110371356A (publication date: 2019-10-25) discloses a vacuum packaging machine for easily oxidized drugs. This packaging machine is equipped with a sealing device inside the body. By sucking out the air in the packaging bag, the drugs are stored in a vacuum state, avoiding oxidation and deterioration of the drugs. This invention provides an anti-oxidation solution, that is, placing the drugs in a vacuum environment and completely isolating them from the air. This is also the most common solution, but the mechanism includes many components and is very complex. Once the vacuum-packed drugs are taken out, they are immediately exposed to oxygen and need to be used up as soon as possible. If they are used up all at once, it will cause waste.

[0006] In view of the above problems, the present invention provides a sealing box for plastic ampoules to improve the storage environment of plastic ampoules, making the storage and transportation of medicines more convenient. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a sealing box for plastic ampoules, which can isolate the ampoule from external oxygen, prevent oxygen from penetrating into the medicine through the plastic bottle body of the ampoule, avoid oxidation and expiration of the medicine, and at the same time record the time when the medicine is taken out to assist in judging the shelf life of the medicine.

[0008] The present invention provides the following technical solution: a sealed box for plastic ampoules, comprising a plurality of back panels and a plurality of ampoule chambers; the plurality of back panels are rectangular thin sheets; the plurality of back panels are of an integrated structure, and a fold is provided at the connection between adjacent back panels; the edges of the plurality of ampoule chambers are provided with rectangular fixed eaves, and the size of the fixed eaves is consistent with that of the back panels; the ampoule chambers are plastic thin sheets with an outer surface covered with aluminum foil; the back panel is a plastic thin sheet with a front surface covered with aluminum foil; the fixed eaves are fixedly connected to the front surface of the back panel; each back panel is fixedly connected to each ampoule chamber to form a sealed box.

[0009] As an embodiment of the present invention, a bone-fitting sealing strip is provided at the fixed connection between the front surface of the backboard and the fixed eaves; the backboard and the ampoule chamber are detachably fixedly connected via the bone-fitting sealing strip.

[0010] As an embodiment of the present invention, an indicator tube is further provided on the front surface of the ampoule chamber; the indicator tube is a vertically arranged transparent closed pipe with an inner diameter of 0.5-0.8 mm and a wall thickness of 0.1 mm; an oxygen indicator is injected into the indicator tube.

[0011] As an embodiment of the present invention, the outer side of the indicator tube is made of polyvinyl chloride, and the inner side is a waterproof and breathable membrane made of ePTFE expanded polytetrafluoroethylene.

[0012] As an embodiment of the present invention, a colorimetric card is further provided on the side of the indicator tube.

[0013] As an embodiment of the present invention, a hoop is further provided on the rear side of the sealing box; the hoop is fixedly connected to the rear surface of the back plate; the hoop is an elastic curling strip.

[0014] As an embodiment of the present invention, a buckle is provided on the rear surface of the back plate; the sealing box located on the outermost circle is detachably fixedly connected to the hoop through the buckle.

[0015] As an embodiment of the present invention, the front surface of the back plate is further provided with an antioxidant coating; the antioxidant coating material is tea polyphenols.

[0016] As an embodiment of the present invention, the fold is provided with a plurality of spindle-shaped tear-assisting notches along the axial direction; and notches are provided at the upper and lower ends of the fold.

[0017] As an embodiment of the present invention, an easy-to-tear label is provided on the upper end of the fixed eaves; and an anti-slip strip is provided on the surface of the easy-to-tear label.

[0018] The beneficial effects of the present invention are as follows:

[0019] 1. The present invention covers the front surface of the back plate and the outer surface of the ampoule chamber with aluminum foil, utilizing the airtightness of the aluminum foil to isolate the sealed box from external oxygen, thereby creating an oxygen-free storage environment for the ampoule, and preventing oxygen from penetrating through the plastic bottle of the ampoule into the medicine and causing the medicine to oxidize and expire.

[0020] 2. The present invention sets an indicator tube on the front surface of the ampoule chamber, injects an oxygen indicator into the indicator tube, and sets a colorimetric card on the side of the indicator tube. By comparing the color of the oxygen indicator with the colorimetric card, the time when the ampoule is taken out can be displayed, and the shelf life of the drug can be inferred.

[0021] 3. The present invention provides an antioxidant coating on the front surface of the back panel and a bone-fitting sealing strip between the front surface of the back panel and the fixed eaves, so that the back panel and the ampoule bin are detachable, and unused medicines can be put back into the sealed box for storage. The antioxidant coating consumes the oxygen filled in the sealed box, re-creating an anaerobic storage environment to continue to store the medicines. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the specific embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0023] Figure 1 This is a schematic diagram of the front side of the sealing box of the present invention;

[0024] Figure 2 This is a schematic diagram of the rear side of the sealing box of the present invention;

[0025] Figure 3 is a schematic diagram of the front side of the back plate of the present invention;

[0026] Figure 4 is a schematic diagram of the rear side of the back plate of the present invention;

[0027] Figure 5 Schematic diagram of the front side of the ampoule chamber of the present invention;

[0028] Figure 6 Schematic diagram of the rear side of the ampoule chamber of the present invention;

[0029] Figure 7 This is a schematic diagram of the connection of the sealing box of the present invention;

[0030] Figure 8 A schematic diagram of a hoop of the present invention;

[0031] Figure 9 This is a schematic diagram of the curling of the final assembly of the present invention;

[0032] Figure 10 It is a schematic diagram of the stretching of the final assembly of the present invention.

[0033] In the figure: sealing box 1, hoop 2, back plate 11, fold 111, buckle 112, antioxidant coating 113, ampoule chamber 12, fixed eaves 121, indicator tube 122, easy-tear label 123, colorimetric card 124, bone sealing strip 13. DETAILED DESCRIPTION

[0034] In order to better understand the above technical solution, the above technical solution will be described in detail below with reference to the accompanying drawings and specific implementation methods.

[0035] Reference Figure 1-10 The present invention discloses a sealed box for plastic ampoules, comprising a plurality of back panels 11 and a plurality of ampoule chambers 12; the plurality of back panels 11 are rectangular thin sheets; the plurality of back panels 11 are of an integrated structure, and a fold 111 is provided at the connection between adjacent back panels 11; the edges of the plurality of ampoule chambers 12 are provided with rectangular fixed eaves 121, and the size of the fixed eaves 121 is consistent with that of the back panels 11; the shape of the ampoule chamber 12 can be designed to fit the specific ampoule, which can minimize the volume and reduce the shaking of the ampoule in the ampoule chamber 12. For plastic ampoules with low storage requirements, the shape of the ampoule chamber 12 can be designed to be rectangular, which is convenient for processing and manufacturing;

[0036] The ampoule bin 12 is a plastic sheet covered with aluminum foil on the outer surface; the back panel 11 is a plastic sheet covered with aluminum foil on the front surface; the aluminum foil is airtight and can isolate external oxygen to prevent it from entering the ampoule bin 12, causing oxygen to penetrate into the ampoule and deteriorate the medicine; the materials of the ampoule bin 12 and the back panel 11 are not fixed, and any material that meets the conditions of isolating oxygen, being non-toxic and inexpensive can be used as the material of the ampoule bin 12 and the back panel 11. For medicines that need to be stored in the dark, the packaging material must also be opaque; the fixed eaves 121 is fixedly connected to the front surface of the back panel 11; each of the back panels 11 is fixedly connected to each of the ampoule bins 12 to form a sealed box 1, and the ampoules are sealed and stored in an oxygen-free environment in the sealed box 1.

[0037] Reference Figure 1 、 2A bone-fitting sealing strip 13 is provided at the fixed connection between the front surface of the back plate 11 and the fixed eaves 121; the back plate 11 and the ampoule bin 12 are detachably fixedly connected through the bone-fitting sealing strip 13; the bone-fitting sealing strip 13 can maintain the airtightness of the sealed box 1. If the ampoule taken out of the sealed box 1 is not used up at one time, it can be put back into the sealed box 1 for storage, and the back plate 11 and the ampoule bin 12 can still be sealed and fitted together through the bone-fitting sealing strip 13;

[0038] The width and cross-sectional structure of the bone-fitting sealing strip 13 should be adapted to the size of the sealing box 1. If the sealing box 1 is larger, the width of the bone-fitting sealing strip should also be increased, and the complexity of the cross-section should also be increased to ensure the firmness of the fit between the back panel 11 and the ampoule chamber 12.

[0039] Reference Figure 5 , an indicator tube 122 is further provided on the front surface of the ampoule bin 12; the indicator tube 122 is a vertically arranged transparent closed pipe, the inner diameter of the indicator tube 122 is 0.5-0.8 mm, and the wall thickness is 0.1 mm; if the capacity of the indicator tube 122 is too large or too small, it will cause too much filling of the oxygen indicator to cause waste or too little oxygen indicator to cause the color to be difficult to see clearly, and the wall thickness of the indicator tube 122 will also have a certain effect on the observation of the color of the oxygen indicator; on the rectangular ampoule bin 12, the shape of the indicator tube 122 is a long strip, and for some ampoule bins 12 of special shapes, the shape of the indicator tube 122 can also be designed accordingly. For example, if the curvature of the surface of the ampoule bin 12 changes complexly, the indicator tube 122 can be designed to be circular and placed in a relatively flat area, or even the indicator tube 122 can be arranged on the back plate 11. The design of the indicator tube 122 needs to facilitate the observation of the color of the oxygen indicator;

[0040] An oxygen indicator is injected into the indicator tube 122. When the sealed box 1 is opened and the ampoule is taken out, the oxygen indicator comes into contact with oxygen and begins to change color. The time when the ampoule has been taken out can be inferred based on the change in color of the oxygen indicator, and then it can be judged whether the medicine in the ampoule has expired. The oxygen indicator can also reflect whether the sealed box 1 is completely sealed. Different medicines have different shelf lives when exposed to oxygen. The selection and configuration of the oxygen indicator need to be targeted at the specific medicine, and the time span of its color change should be roughly the same as the shelf life of the medicine.

[0041] Reference Figure 5The outer side of the indicator tube 122 is made of polyvinyl chloride, and the inner side is a waterproof and breathable membrane made of ePTFE expanded polytetrafluoroethylene; the polyvinyl chloride material on the outer side of the indicator tube 122 is transparent, non-toxic and oxygen-isolating, which makes it convenient to observe the color change of the oxygen indicator and prevents the oxygen indicator from contacting the oxygen outside the sealed box 1. Other transparent, non-toxic and oxygen-isolating materials can also be used as the material of the indicator tube 122; the indicator tube 122 is bonded to the ampoule chamber 12 by oxygen-isolating glue; a colorimetric card 124 is also provided on the side of the indicator tube 122. For different types of oxygen indicators, the color provided by the colorimetric card 124 needs to be adjusted accordingly; by comparing the color of the oxygen indicator with the colorimetric card, the drug removal time and shelf life can be inferred more conveniently and accurately.

[0042] Reference Figure 8-10 , a hoop 2 is further provided on the rear side of the sealed box 1; the hoop 2 is fixedly connected to the rear surface of the back plate 11; the hoop 2 is an elastic curling strip; when the sealed box 1 is in a general storage state, the hoop 2 is in a curled state, and multiple sealed boxes 1 are constrained by the hoop 2 to form a polygonal cylinder; when the sealed box 1 is taken out, the hoop 2 can be straightened and kept in a straight state, which is convenient for taking out the outermost sealed box 1. After taking out, the hoop 2 can be lightly folded to restore the hoop 2 to a bent state, and multiple sealed boxes 1 surround the cylinder again, reducing the occupied space and facilitating storage and transportation; a buckle 112 is provided on the rear surface of the back plate 11; the sealed box 1 located at the outermost circle is detachably fixedly connected to the hoop 2 by the buckle 112; the used ampoule and its corresponding sealed box 1 can be removed from the hoop 2 to reduce the overall volume.

[0043] Reference Figure 3 , the front surface of the back plate 11 is also provided with an antioxidant coating 113; when the unused ampoule of medicine in the bottle is put back into the sealed box 1, the sealed box 1 is filled with oxygen because it has been opened. At this time, the antioxidant coating can consume the oxygen in the sealed box 1 to prevent oxygen from oxidizing the medicine; the material of the antioxidant coating 113 is tea polyphenols, which is inexpensive and a naturally extracted material with no toxicity; in addition to tea polyphenols, other antioxidants can also be used as materials for the antioxidant coating, such as natural antioxidant phytic acid, synthetic antioxidants BHA, BHT, PG, etc.

[0044] Reference Figure 7The fold 111 is provided with a plurality of spindle-shaped tear-aiding notches along the axial direction; notches are provided at the upper and lower ends of the fold 111; the adjacent back panels 11 can be torn along the fold 111, and the notches and tear-aiding notches make the fold 111 have high tensile strength and easy to shear, which can prevent the back panel 11 from being torn when the back panel 11 is torn off, resulting in a reduction in the airtightness of the sealed box 1; an easy-tear label 123 is provided at the upper end of the fixed eaves 121; the back panel 11 and the ampoule chamber 12 can be more conveniently disassembled by pulling the easy-tear label 123; an anti-slip strip is provided on the surface of the easy-tear label 123; the anti-slip strip can increase the friction when the easy-tear label 123 is pulled.

[0045] During use, the hoop 2 is first straightened, and the outermost ampoule compartment 12 is removed from the back plate 11 by pulling the tear-off label 123, and the ampoule in the sealed box 1 is taken out for use. When the sealed box 1 is opened, oxygen enters the ampoule compartment 12 and contacts the oxygen indicator through the waterproof and breathable membrane. The color of the oxygen indicator begins to change over time and can be observed through the transparent indicator tube 122. By comparing with the color chart, the length of time the ampoule has been taken out can be inferred, and then the shelf life of the medicine in the ampoule can be judged.

[0046] If the medicine in the ampoule has not been used up at one time and has not expired, the ampoule can be put back into the sealed box 1, and the edges of the fixed eaves 121 and the back plate 11 can be pinched to reseal the bone sealing strip 13. At this time, the sealed box 1 is filled with oxygen, and the antioxidant coating 113 can consume the oxygen in the sealed box 1 to prevent the medicine in the ampoule from being oxidized by oxygen and deteriorating. At the same time, since the sealed box 1 is restored to an oxygen-free environment, the color change of the oxygen indicator also stops.

[0047] When the medicine in the ampoule is completely used up or expired, the ampoule and the corresponding sealed box 1 can be removed from the hoop 2 and discarded, and the hoop 2 can be gently folded to restore it to a curled state. The hoop 2 drives the remaining multiple sealed boxes 1 to form a column, which reduces the floor space and is convenient for storage and transportation.

[0048] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the foregoing embodiments. The foregoing embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A sealed box for plastic ampoules, characterized in that: The invention comprises a plurality of back plates (11) and a plurality of ampoule chambers (12); the plurality of back plates (11) are rectangular thin sheets; the plurality of back plates (11) are an integrated structure, and a fold (111) is provided at the connection between adjacent back plates (11); the edges of the plurality of ampoule chambers (12) are provided with rectangular fixed eaves (121), and the size of the fixed eaves (121) is consistent with that of the back plates (11); the ampoule chambers (12) are plastic thin sheets with an outer surface covered with aluminum foil; the back plate (11) is a plastic thin sheet with an aluminum foil covered on the front surface; the fixed eaves (121) are fixedly connected to the front surface of the back plate (11); each back plate (11) is fixedly connected to each ampoule chamber (12) to form a sealed box (1); The front surface of the ampoule chamber (12) is further provided with an indicator tube (122); the indicator tube (122) is a vertically arranged transparent closed pipe, the inner diameter of the indicator tube (122) is 0.5-0.8 mm, and the wall thickness is 0.1 mm; an oxygen indicator is injected into the indicator tube (122); The front surface of the back plate (11) is further provided with an antioxidant coating (113); the material of the antioxidant coating (113) is tea polyphenols; A bone-fitting sealing strip (13) is provided at the fixed connection between the front surface of the backboard (11) and the fixed eaves (121); the backboard (11) and the ampoule chamber (12) are detachably fixedly connected via the bone-fitting sealing strip (13); A hoop (2) is further provided on the rear side of the sealing box (1); the hoop (2) is fixedly connected to the rear surface of the back plate (11); the hoop (2) is an elastic curling strip; A buckle (112) is provided on the rear surface of the back plate (11); the sealing box (1) located at the outermost circle is detachably fixedly connected to the hoop (2) via the buckle (112).

2. The sealed box for plastic ampoules according to claim 1, characterized in that: The outer side of the indicator tube (122) is made of polyvinyl chloride, and the inner side is a waterproof and breathable membrane made of ePTFE expanded polytetrafluoroethylene.

3. The sealed box for plastic ampoules according to claim 1, characterized in that: A colorimetric card (124) is also provided on the side of the indicator tube (122).

4. The sealing box for plastic ampoules according to claim 1, characterized in that: The fold (111) is provided with a plurality of spindle-shaped tear-assisting notches along the axial direction; and notches are provided at the upper and lower ends of the fold (111).

5. The sealing box for plastic ampoules according to claim 1, characterized in that: An easy-to-tear label (123) is provided at the upper end of the fixed eaves (121); and an anti-slip strip is provided on the surface of the easy-to-tear label (123).

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