Modular simultaneous diagnostic polymerase chain reaction system

Abstract

The present invention relates to a modular simultaneous diagnosis polymerase chain reaction system, and more particularly, to a modular simultaneous diagnosis polymerase chain reaction system in which a plurality of placement grooves for placing biochips are formed on an upper surface of a main body case, a plurality of heating and cooling modules and a plurality of light source modules are provided in the main body case in correspondence with the placement grooves, a plurality of cover members including detection modules corresponding to the placement grooves are provided on the upper surface of the main body case in a manner rotatable up and down, and a plurality of the heating and cooling modules, the light source modules, and the detection modules are integrally controlled by a control module provided in the main body case, so that polymerase chain reaction tests on samples accommodated in the biochips can be simultaneously performed, a plurality of polymerase chain reaction operations become simple, maintenance costs are reduced, and product prices can be reduced by omitting repeated components.

Description

[0001] Cross-referencing

[0002] This application claims priority to Korean Patent Application 10-2021-0069619, filed on May 30, 2021, the entire contents of which are incorporated herein by reference. Technical Field

[0003] The present invention relates to a polymerase chain reaction (PCR) device, and more specifically, to a modular simultaneous diagnostic polymerase chain reaction system comprising multiple polymerase chain reaction modules disposed within a single device, which can be controlled by a single control module. Background Technology

[0004] Polymerase chain reaction (PCR) is a technique that uses repeated heating and cooling of a sample solution containing nucleic acid molecules to amplify the target nucleic acid in an exponential manner by repeatedly replicating sites with specific base sequences. It is a technique that can detect target genes by replicating trace amounts of nucleic acid.

[0005] This polymerase chain reaction (PCR) method repeatedly involves DNA denaturation, annealing, and DNA synthesis steps. The denaturing step involves heating a sample solution containing double-stranded template DNA at a specific temperature, such as approximately 95°C, for 5 seconds to separate the double-stranded DNA into single-stranded DNA. The annealing step, following the denaturation step, involves injecting primers with sequences complementary to the specific base sequence to be amplified into the sample solution and cooling them together with the single-stranded DNA at a specific temperature, such as 50°C, for 5 seconds. This allows the primers to hybridize with the specific base sequence of the single-stranded DNA to form a partial DNA-primer complex. The DNA synthesis step… Step (1) is a step following the annealing step, where the sample solution is held at the activation temperature of deoxyribonucleic acid polymerase, for example, 72°C, for 5 seconds, thereby allowing the deoxyribonucleic acid polymerase to form double-stranded deoxyribonucleic acid based on the primers of a partial deoxyribonucleic acid-primer complex. Furthermore, the target nucleic acid can be detected by detecting the fluorescence produced by the fluorescent dye binding to it.

[0006] Figure 1 This is a simplified structural diagram of a prior art polymerase chain reaction (PCR) device. Figure 2 yes Figure 1 The diagram shows the operational status of the polymerase chain reaction apparatus.

[0007] As shown in the figure, the existing polymerase chain reaction device 100 mainly includes a main shell 110, a polymerase chain reaction module 120, a control module 130, and a biochip 140.

[0008] The aforementioned main body shell 110 forms the appearance of the polymerase chain reaction device 100, is hexahedral in shape, and has a space of a predetermined size inside. The aforementioned polymerase chain reaction module 120 heats and cools the reactants contained in the biochip 140, is cuboid in shape, and is configured to be slidable into the interior of the main body shell 110 through an opening formed on the front surface of the main body shell 110 for storage.

[0009] The control module 130 is disposed inside the main body shell 110 and is electrically connected to the polymerase chain reaction module 120. It controls the polymerase chain reaction module 120 to perform a predetermined polymerase chain reaction process.

[0010] The biochip 140 has multiple chambers for containing reactants containing samples and reagents. The placement groove 122 formed on the upper surface of the polymerase chain reaction module 120 is disposed inside the main body shell 110 together with the polymerase chain reaction module 120.

[0011] Furthermore, the polymerase chain reaction module 120 includes a heating and cooling module 150 for heating and cooling the biochip 140 placed in the placement slot 122, and a light source module 160 for irradiating the side of the biochip 140 with light of a predetermined wavelength. The heating and cooling module 150 includes a heating plate 151, a heat sink 153, and a cooling fan 155, while the light source module 160 includes multiple light-emitting diodes (LEDs) 161 and a filter 163.

[0012] Furthermore, inside the main housing 110, a detection module 170 is disposed above the placement slot 122 to detect fluorescence emitted from the biochip 140 placed in the placement slot 122 of the polymerase chain reaction module 120. The detection module 170 includes an image sensor 171 and a filter 173.

[0013] Furthermore, a display panel 180 is provided on the upper surface of the main housing 110 in a manner that allows it to rotate up and down. The control module 130 includes a control unit 131 and a power supply unit 133. Unspecified reference numeral 135 indicates a blower.

[0014] As described above, in the existing polymerase chain reaction (PCR) apparatus 100, a PCR module 120 is disposed inside the main housing 110. Since the control module 130 cannot control the PCR module 120 and the display panel 180, it is impossible to simultaneously perform PCR testing on multiple samples. Furthermore, the existing display panel 180 has a structure that allows it to rotate vertically on the upper surface of the main housing 110, resulting in difficulties in using large-area panels and a weak structure. Additionally, in the existing structure, the control module 130 is fixed inside the main housing 110, making maintenance and replacement difficult.

[0015] In other words, in order to perform polymerase chain reaction (PCR) tests on multiple samples simultaneously using existing PCR devices, multiple PCR devices 100 need to be prepared, which increases the equipment purchase cost. Furthermore, since multiple PCR devices 100 need to be used for PCR tests, the operation becomes more complex and maintenance costs increase. Summary of the Invention

[0016] Technical issues

[0017] The present invention addresses the problems of the prior art. The main objective of the present invention is to provide a modular simultaneous diagnostic polymerase chain reaction (PCR) system that can simultaneously perform PCR tests on multiple samples using a single PCR system.

[0018] Furthermore, the object of the present invention is to provide a modular simultaneous diagnostic polymerase chain reaction (PCR) system as follows: multiple PCR modules are arranged in a main body shell, and multiple heating and cooling modules, multiple light source modules, multiple detection modules and multiple display panels constituting the multiple PCR modules are integrated and controlled by a control module arranged inside the main body shell. Multiple samples can be tested by PCR simultaneously. Since a single PCR device is used, the operation is simple and the maintenance cost can be reduced. By omitting repetitive components, the product price can be greatly reduced.

[0019] Furthermore, the present invention aims to provide a modular simultaneous diagnostic polymerase chain reaction system that achieves structural stability and allows for the application of a large-area panel by providing a display device on the front surface of a polymerase chain reaction apparatus.

[0020] Problem-solving methods

[0021] One means for achieving this objective of the invention, the modular simultaneous diagnostic polymerase chain reaction system of the invention, is characterized by comprising:

[0022] The main outer shell constitutes the exterior appearance and forms the internal space of a specified size;

[0023] Multiple biochips are placed in multiple placement slots, which are recessed on the upper surface of the main body shell.

[0024] Multiple heating and cooling modules are disposed inside the main body shell at the lower part of the multiple placement slots, for heating or cooling the biochip;

[0025] Multiple light source modules are disposed inside the main body shell in such a way that they are located on the sides of the multiple placement slots, for irradiating light onto the sides of the biochip.

[0026] Multiple cover components are rotatably mounted on the upper surface of the main body shell, including a detection module positioned above the placement slot to measure fluorescence emitted from the biochip; and

[0027] A control module is located inside the main body shell and is electrically connected to the multiple heating and cooling modules, light source module and detection module to control them.

[0028] In this invention, a display panel is also provided on the front surface of the main body shell. The display panel is arranged in a way that allows it to rotate up and down and is electrically connected to the control module.

[0029] A height difference of a predetermined height is formed in the center of the upper surface of the main body shell to form a stepped shape. Centered on the height difference, a lower upper plate is provided in front and an upper upper plate is provided in the rear. The aforementioned multiple cover components are provided on the lower upper plate and the upper upper plate in a manner that allows them to rotate up and down.

[0030] An opening of a predetermined size is formed on the front panel of the main body shell, allowing the connecting rod component that rotatably supports the display panel to enter and exit the interior of the main body shell. An opening of a predetermined size is formed on the rear panel of the main body shell, allowing the control module to slide forward or backward for storage.

[0031] The upper plate of the main body shell has multiple openings corresponding to the multiple placement slots. A placement plate with a central through hole is provided at the lower part of the openings to form the placement slots. A support plate for supporting the heating and cooling module is fixedly provided at the lower part of the placement plate. A hinge component for supporting the cover component is vertically provided on the upper rear surface of the support plate in a way that allows it to rotate up and down. Horizontal fixing shafts for fixing the cover component are provided on the upper left and right sides of the support plate. The light source module is provided on the placement plate in a way that it is located on the side of the placement slot.

[0032] The above-mentioned cover member includes: a housing that forms an internal space of a specified size and has a through-hole corresponding to the above-mentioned placement groove formed on the bottom surface; and a handle in a "C" shape, which is provided on the front surface and the left and right sides of the above-mentioned housing. A setting groove is formed at the rear end of the above-mentioned housing, and the above-mentioned rotating member is provided in the above-mentioned setting groove.

[0033] The above-mentioned detection module is provided inside the above-mentioned cover member in a manner located above the above-mentioned placement groove, and a light-emitting diode display portion for transmitting light to the upper surface of the above-mentioned cover member is provided in front of the above-mentioned placement groove.

[0034] The above-mentioned light-emitting diode display portion includes: a light-emitting diode substrate on which a plurality of light-emitting diodes are horizontally arranged; a light guide plate formed of a transparent material and having at least 4 reflecting surfaces, so that the light emitted from the above-mentioned light-emitting diode substrate can be transmitted upward through the plurality of reflecting surfaces; and a base that fixes the above-mentioned light-emitting diode substrate and the light guide plate to the bottom surface of the above-mentioned cover member by supporting them.

[0035] Central grooves are formed on the inner side surfaces at both ends of the above-mentioned handle, and a rotating shaft protruding from the outer side surface of the above-mentioned cover member is inserted into the above-mentioned central grooves. The above-mentioned handle is provided in a rotatable manner with the above-mentioned central grooves as the center, and a guide groove is formed for the horizontal fixing shaft provided on the upper surface of the above-mentioned support plate and protruding toward the upper surface of the above-mentioned main body housing to be inserted and moved. The above-mentioned guide groove is formed to be downwardly open when the above-mentioned handle rotates upward and stands vertically, and when the above-mentioned handle rotates downward and lies horizontally, it functions to fix the above-mentioned horizontal fixing shaft so that it cannot be detached.

[0036] A hinge that enables the above-mentioned display panel to rotate up and down is provided at the upper end of the front surface of the above-mentioned main body housing. The above-mentioned link member includes: two fixing blocks that are fixedly separated at a specified interval on the bottom plate of the above-mentioned main body housing; two lower link members that are provided in a vertically rotatable manner on a lower horizontal fixing shaft that horizontally penetrates the two above-mentioned fixing blocks; two upper link members that are provided in a vertically rotatable manner on an intermediate horizontal fixing shaft that horizontally penetrates the upper ends of the two above-mentioned lower link members; and two fixing brackets that are provided in a vertically rotatable manner on an upper horizontal fixing shaft that horizontally penetrates the upper ends of the two above-mentioned upper link members and are fixed to the rear surface of the above-mentioned display panel.

[0037] The above-mentioned plurality of heating and cooling modules, plurality of light source modules, plurality of detection modules, and plurality of display panels are controlled by the above-mentioned one control module.

[0038] Effects of the Invention

[0039] The present invention has the following advantages: According to the modular simultaneous diagnostic polymerase chain reaction (PCR) system, multiple placement slots for placing biochips are formed on the upper surface of a main body shell. Inside the main body shell, multiple heating and cooling modules and multiple light source modules are arranged corresponding to the placement slots. On the upper surface of the main body shell, multiple cover components including detection modules corresponding to the placement slots are arranged in a rotatable manner. The multiple heating and cooling modules, multiple light source modules and multiple detection modules are integrated and controlled by a control module located inside the main body shell. Thus, polymerase chain reaction (PCR) tests can be performed simultaneously on samples containing multiple biochips, simplifying the operation of multiple PCRs, reducing maintenance costs, and reducing product price by omitting repetitive components. Attached Figure Description

[0040] Figure 1 This is a simplified structural diagram of a portable polymerase chain reaction device in the prior art.

[0041] Figure 2 It is shown Figure 1 The diagram shows the structural configuration of an existing portable polymerase chain reaction device in use.

[0042] Figure 3 This is a simplified structural diagram illustrating the modular simultaneous diagnostic polymerase chain reaction system of the present invention.

[0043] Figure 4 It is shown Figure 3 The diagram shows the operational status of the modular simultaneous diagnostic polymerase chain reaction system.

[0044] Figure 5 and Figure 6 This is a perspective view illustrating a preferred embodiment of the modular simultaneous diagnostic polymerase chain reaction system of the present invention.

[0045] Figure 7 It is shown in Figure 5 The diagram shows a three-dimensional view of a portion of the cap component in a modular simultaneous diagnostic polymerase chain reaction system, with the display panel rotating.

[0046] Figure 8 It is shown in Figure 6 The diagram shows a three-dimensional representation of the state of the separation control module in a modular simultaneous diagnostic polymerase chain reaction system.

[0047] Figure 9 This is a perspective view showing a preferred embodiment of the main body shell of the present invention.

[0048] Figure 10 This is a perspective view illustrating a preferred embodiment of the heating and cooling module of the present invention.

[0049] Figure 11 It is shown in Figure 10 The diagram shows a three-dimensional view of the heating and cooling module with a mounting plate on its upper part.

[0050] Figure 12 This is a perspective view showing the internal structure of the cover component of the present invention.

[0051] Figure 13 It is shown Figure 12 A perspective view of the handle of the cover component shown.

[0052] Figure 14 and Figure 15 This is a perspective view showing an example of the light-emitting diode display section of the present invention.

[0053] Figure 16 This is a perspective view showing a preferred embodiment of the connecting rod component for supporting the display panel of the present invention. Detailed Implementation

[0054] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. These embodiments are exemplary and do not limit the invention in any way.

[0055] Figure 3 This is a simplified structural diagram of the modular simultaneous diagnostic polymerase chain reaction system of the present invention. Figure 4 It is shown Figure 3 The diagram shows the usage status of the modular simultaneous diagnostic polymerase chain reaction system.

[0056] As shown in the figure, the modular simultaneous diagnostic polymerase chain reaction system 1 of the present invention includes: a main shell 10, which constitutes the appearance and forms an internal space of a specified size; and a plurality of biochips 40, which are placed in a plurality of placement slots 12, the plurality of placement slots 12 being formed on the upper surface of the main shell 10.

[0057] Furthermore, inside the main body shell 10, a plurality of heating and cooling modules 50 are disposed at the lower part of the plurality of placement slots 12 in a manner corresponding to the plurality of placement slots 12, and a plurality of light source modules 60 are disposed on the side of the placement slots 12 in a manner corresponding to the placement slots 12.

[0058] Furthermore, on the upper surface of the main body shell 10, a plurality of cover components 20 are disposed on the upper part of the plurality of placement slots 12 in a manner corresponding to and rotatable up and down. Inside the cover components 20, detection modules 70 are disposed on the upper part of the plurality of placement slots 12 in a manner corresponding to the plurality of placement slots 12.

[0059] Furthermore, a control module 30 is provided inside the main body shell 10. The control module 30 is electrically connected to and controls the plurality of heating and cooling modules 50, light source module 60 and detection module 70.

[0060] In addition, a display panel 80 electrically connected to the control module 30 is provided on the front surface of the main housing 10 in a manner that allows it to rotate up and down.

[0061] Specifically, the aforementioned main body shell 10 has a hexahedral structure formed of plastic and metal materials, including: a lower plate forming the bottom surface; two side plates forming two side surfaces; an upper plate 11 forming the upper surface; a front plate forming the front surface; and a rear plate forming the rear surface.

[0062] Preferably, a height difference portion of a predetermined height is formed at the center of the upper plate 11 to form a stepped shape, and a lower upper plate 11a is provided at the front and an upper plate 11b is provided at the rear, with the height difference portion as the center.

[0063] An opening of a specified size is formed on the upper plate 11, which corresponds to the plurality of placement slots 12, allowing the biochip 40 to pass through. The heating and cooling module 50 is provided on the lower side of the opening.

[0064] The aforementioned heating and cooling module 50 includes a heating plate 51, a heat sink 53, and a cooling fan 55. The heating plate 51 is formed from a flat plate of a specified thickness, thus forming the bottom surface of the placement slot 12. When a predetermined power supply is provided, the heating plate 51 generates heat or cold air to heat and cool the biochip 40 located on it. A heat sink 53 is provided at the lower part of the heating plate 51, and multiple heat dissipation pins are formed on the heat sink 53. Furthermore, the cooling fan 55 is vertically disposed behind the heat sink 53.

[0065] The aforementioned biochip 40 is formed from a substrate having dimensions suitable for placement in the placement slot 12, and is made of a transparent material with good light transmittance. Internally, it has multiple chambers for accommodating reactants including reagents and samples. Preferably, the bottom surface of the biochip 40 can be formed from a thin sealing film with excellent thermal conductivity.

[0066] The aforementioned light source module 60 is disposed on the side of the aforementioned placement slot 12, and the irradiated light passes through multiple chambers by irradiating the side of the biochip 40 placed in the aforementioned placement slot 12. The aforementioned filter 63 can allow only light of a specific wavelength to pass through.

[0067] The cover component 20 is used to cover the placement groove 12 formed on the upper surface of the main body shell 10. When the biochip 40 is inserted into or removed from the placement groove 12, it rotates upward to open. When the biochip 40 in the placement groove 12 is subjected to a polymerase chain reaction process, it rotates downward to close the upper part of the placement groove 12.

[0068] The cover component 20 includes: a housing 21 having dimensions that can completely cover the placement slot 12; and a hinge component 25 that supports the housing 21 in a manner that allows it to rotate up and down relative to the main housing 10.

[0069] Furthermore, the detection module 70 is disposed inside the cover component 20. In order to detect the fluorescence emitted from the biochip 40, the detection module 70 is positioned above the placement slot 12 when the cover component 20 is rotated toward the upper surface of the main body shell 10.

[0070] The aforementioned display panel 80 is used to display the process or results of the polymerase chain reaction and is mounted on the front surface of the main housing 10 in a manner that allows it to rotate back and forth. Furthermore, the aforementioned control module 30 is disposed inside the main housing 10 and is electrically connected to the plurality of heating and cooling modules 50, the plurality of light source modules 60, the plurality of detection modules 70, and the display panel 80.

[0071] As described above, in the modular simultaneous diagnostic polymerase chain reaction system 1 of the present invention, multiple placement slots 12 are formed separately so that multiple biochips 40 can be placed on the upper surface of a main body shell 10. Inside the main body shell 10, multiple heating and cooling modules 50 are provided at the lower part of the multiple placement slots 12 in a manner corresponding to the multiple placement slots 12. Multiple light source modules 60 are provided on the sides of the multiple placement slots 12. On the upper surface of the main body shell 10, multiple cover members 20 are provided in a manner corresponding to the multiple placement slots 12 and rotatable up and down. Inside the cover members 20, detection modules 70 are provided at the upper part of the multiple placement slots 12 in a manner corresponding to the multiple placement slots 12. A control module 30 provided inside the main body shell 10 is used to integrate and control the multiple heating and cooling modules 50, the multiple light source modules 60 and the multiple detection modules 70.

[0072] Figure 5 and Figure 6 This is a perspective view illustrating a preferred embodiment of the modular simultaneous diagnostic polymerase chain reaction system of the present invention. Figure 7 It is shown in Figure 5 The diagram shows a three-dimensional representation of a modular simultaneous diagnostic polymerase chain reaction (PCR) system, depicting a portion of the cap assembly being separated and the display panel being rotated. Figure 8It is shown in Figure 6 The diagram shows a three-dimensional representation of the state of the separation control module in a modular simultaneous diagnostic polymerase chain reaction system.

[0073] As shown in the figure, the modular simultaneous diagnostic polymerase chain reaction system 1 of this embodiment includes: a hexahedral-shaped main body shell 10; a plurality of cover components 20, which are disposed at predetermined intervals on the upper surface of the main body shell 10; and a display panel 80, which is disposed on the front surface of the main body shell 10.

[0074] The upper surface of the main body shell 10 is divided into a lower upper plate 11a and an upper upper plate 11b, centered on the height difference in the center. Two cover components 20 are provided on the lower upper plate 11a and the upper upper plate 11b respectively. In this case, a handle 23 is provided on the front surface of each cover component 20.

[0075] like Figure 6 As shown, an opening of a predetermined size is formed on the rear surface of the main housing 10, and a rear cover 16 is detachably provided in the opening. In this case, a connector for connecting various cables is formed in the rear cover 16. Therefore, when the rear cover 16 is separated, the control module 30 provided in the main housing 10 can be easily separated. In this case, a guide rail 18 for guiding the control module 30 is provided inside the main housing 10.

[0076] like Figure 7 As shown, a plurality of placement slots 12 are formed on the upper surface 11 of the main housing 10 to accommodate the biochip 40. Furthermore, a hinge member 25 is vertically disposed behind the placement slot 12, supporting the cover member 20 in a manner that allows it to rotate vertically. Locking members 45 are vertically disposed on the left and right sides of the placement slot 12, and the locking members 45 include a horizontal fixing shaft 44 that uses the handle 23 to fix the cover member 20 to the main housing 10.

[0077] Figure 9 A preferred embodiment of the main housing 10 of the present invention is shown. An opening 14 is formed on the front surface of the main housing 10, allowing the connecting rod member 85, which rotatably supports the display panel 80, to enter and exit. Furthermore, four through portions 15 for forming placement grooves 12 are formed on the upper surface of the main housing 10, and four through holes 19 for mounting four hinge members 25 are formed behind the through portions 15. In addition, a plurality of ventilation openings are formed in the height difference portion 13 formed in the center of the upper plate 11.

[0078] then, Figure 10It is a perspective view showing a preferred embodiment of the heating and cooling module 50 of the present invention. As shown in the figure, the above-mentioned heating and cooling module 50 includes a support plate 56 coupled to the lower part of the upper plate 11 of the main body housing 10. A through-hole for arranging a heat dissipation block 53 and a heat dissipation fan 55 is formed in the center of the support plate 56, and coupling brackets 58 for coupling with the upper plate 11 are vertically arranged on the upper surfaces of the left and right sides.

[0079] In addition, a heating plate 51 with a specified size is horizontally arranged on the upper surface of the heat dissipation block 53 arranged on the support plate 56. And a power connection part and a printed circuit board are arranged on one side of the heating plate 51. In addition, the heat dissipation fan 55 is vertically arranged behind the heat dissipation block 53.

[0080] Next, Figure 11 It is a perspective view showing a state in which a placement plate 59 is arranged on the upper part of the heating and cooling module 50 of the present invention. The placement plate 59 is formed of a plastic material, and a through-hole is formed in the center so that the biochip 40 can pass through. In addition, locking components 45 are arranged on the left and right sides of the placement plate 59, and a horizontal fixing shaft 44 for fixing the cover component 20 is formed in the locking component 45. And setting grooves 66 for arranging a light source module 60 are horizontally formed on the left and right sides of the placement groove 12. At the same time, a hinge component 25 for supporting the cover component 20 in a vertically rotatable manner is vertically arranged on the upper surface of the rear end of the support plate 56.

[0081] Next, Figure 12 It is a perspective view showing the internal structure of the cover component of the present invention. As shown in the figure, the cover component 20 includes: a housing 21 forming an internal space with a specified size; and a handle 23 in a "C" shape surrounding a part of the front surface and the side surface of the housing 21 and arranged in a vertically rotatable manner. A through-hole 22 is formed at the bottom of the housing 21 corresponding to the placement groove 12, and an image sensor 71 and a filter 73 (not shown) are arranged above the through-hole 22. In addition, a light-emitting diode display part 90 is vertically arranged in front of the through-hole 22. The reference numeral 26 not described indicates a setting groove where the hinge component 25 is arranged.

[0082] As Figure 13As shown, the above-mentioned handle 23 is in a "C" shape, and central grooves 126 are formed on the inner sides of both ends. A rotary shaft protruding from the outer side of the above-mentioned cover member 20 is inserted into the central grooves 126, and the handle 23 is arranged to be rotatable about the central grooves 126. Also, a guiding groove 128 is formed outside the central grooves 126, and a horizontal fixing shaft 44 of a locking member 45 provided on the upper surface of the above-mentioned support plate 56 is inserted into the guiding groove 128. A part 128a of the guiding groove 128 is open when the handle 23 is rotated upward and erected vertically, so that the horizontal fixing shaft 44 can be disengaged downward, and the horizontal fixing shaft 44 is fixed and cannot be disengaged when the handle 23 is rotated downward. In addition, the reference numeral 127 (not shown) denotes a guiding groove, and a separate guiding pin for guiding the smooth rotation of the above-mentioned handle 23 is inserted into the guiding groove.

[0083] Figure 14 and Figure 15 is a perspective view showing an example of a light-emitting diode display unit 90 of the present invention. As shown in the figure, the above-mentioned light-emitting diode display unit 90 is used to transmit the working state of the polymerase chain reaction module to the upper surface of the cover member 20, and includes: a light-emitting diode substrate 91, connected to a printed circuit board provided inside the above-mentioned cover member 20, on which a plurality of light-emitting diodes are arranged; a light guide plate 93 for transmitting the light emitted from the above-mentioned light-emitting diode substrate 91 upward; and a base 95 for fixing the lower ends of the above-mentioned light-emitting diode substrate 91 and the light guide plate 93 by combining them and fixing them to the bottom surface of the above-mentioned cover member 20. In particular, the above-mentioned light guide plate 93 is formed of a transparent material and has at least 4 reflecting surfaces inclined at an angle of 45°, so that the light incident horizontally from the lower end is reflected upward and vertically emitted from the upper surface of the above-mentioned cover member 20.

[0084] Figure 16 is a perspective view showing a preferred embodiment of a link member 84 for supporting a display panel of the present invention. As shown in the figure, the above-mentioned link member 85 includes: two fixing blocks 851, fixed at a predetermined interval at the bottom of the above-mentioned main body housing 10; two lower link members 853, arranged to be rotatable up and down about a lower horizontal fixing shaft 852 horizontally penetrating the two fixing blocks 851; two upper link members 855, arranged to be rotatable up and down about an intermediate horizontal fixing shaft 854 horizontally penetrating the upper ends of the two lower link members 853; and two fixing brackets 857, arranged to be rotatable up and down about an upper end horizontal fixing shaft 856 horizontally penetrating the upper ends of the two upper link members 855 and fixed to the rear surface of the above-mentioned display panel 80.

[0085] Also, a front cover plate 858 of a predetermined size is provided on the front surface of the above-mentioned upper link member 855 to block the opening.

[0086] As described above, in the modular simultaneous diagnostic polymerase chain reaction system 1 of the present invention, since a plurality of placement slots 12 are provided on the upper surface of the main housing 10, biochips 40 can be placed in the plurality of placement slots 12 after the plurality of cover members 20 are rotated upward and opened. Furthermore, when placing the biochip 40, the cover members 20 are rotated downward. In this case, when the handle 23 of the cover member 20 is rotated downward, the cover member 20 is fixed by the locking member 45.

[0087] Next, the control module 30, located inside the main housing 10, controls multiple heating and cooling modules 50, multiple light source modules 60, and multiple detection modules 70 to perform polymerase chain reaction (PCR) processes on the multiple biochips 40. Furthermore, the process and results of each PCR process are displayed on the display panel 80.

[0088] The preferred embodiments of the present invention have been described in detail above, but the scope of the present invention is not limited thereto, and various modifications and improvements made by those skilled in the art using the basic concepts of the present invention as defined in the appended claims also fall within the scope of the present invention.

Claims

1. A modular simultaneous diagnostic polymerase chain reaction system, comprising: The main outer shell constitutes the exterior appearance and forms an internal space of specified dimensions; Multiple placement slots are recessed on the upper surface of the main body shell to accommodate multiple biochips; Multiple heating and cooling modules are disposed inside the main body housing at the lower part of the multiple placement slots for heating or cooling the biochip; multiple light source modules are disposed inside the main body housing at the sides of the multiple placement slots for irradiating light onto the sides of the biochip; and multiple cover components are disposed on the upper surface of the main body housing in a way that allows them to rotate up and down to cover the multiple placement slots. The modular simultaneous diagnostic polymerase chain reaction system is characterized in that… A stepped section with a predetermined height difference is formed at the center of the upper surface of the main body shell. Centered on this height difference, a lower upper plate is located at the front, and an upper upper plate is located at the rear. A display panel is also provided on the front surface of the main body shell. The display panel is rotatable and displays the working status of the polymerase chain reaction (PCR) module. A control module is located inside the main body shell for controlling the PCR module. The aforementioned cover components include: The shell is provided on the lower and upper plates of the main body shell in a manner that allows it to rotate up and down, forming an internal space of a specified size, and a through part corresponding to the placement groove is formed on the bottom surface. A rotating component is located at the rear of the aforementioned housing, enabling the aforementioned housing to rotate up and down; The handle surrounds a portion of the front surface and two sides of the aforementioned housing, allowing the housing to rotate up and down about the aforementioned rotating component. A detection module is disposed above the aforementioned through-hole to measure the fluorescence emitted from the biochip placed in the aforementioned placement slot; and A light-emitting diode display unit is vertically disposed in front of the aforementioned through-hole, and transmits the operating status of the polymerase chain reaction module to the upper surface of the aforementioned cover component via light. The aforementioned control module is configured to be retracted by sliding forward and backward through an opening formed in the rear panel of the main body housing, and is electrically connected to control the aforementioned multiple heating and cooling modules, light source module, detection module, LED display unit, and display panel. The aforementioned light-emitting diode display unit includes: a light-emitting diode substrate having a plurality of light-emitting diodes arranged horizontally; a light guide plate formed of a transparent material having at least four reflective surfaces to transmit light emitted from the light-emitting diode substrate upward through the plurality of reflective surfaces; and a base for fixing the light-emitting diode substrate and the light guide plate to the bottom surface of the aforementioned cover member by supporting them.

2. The modular simultaneous diagnostic polymerase chain reaction system according to claim 1, characterized in that, An opening of a predetermined size is formed on the front panel of the main body housing, allowing the connecting rod component that supports the display panel in a rotatable manner to enter and exit the interior of the main body housing.

3. The modular simultaneous diagnostic polymerase chain reaction system according to claim 1, characterized in that, The upper plate of the main body shell has multiple openings corresponding to the multiple placement slots. A placement plate with a central through hole is provided at the lower part of the openings to form the placement slots. A support plate for supporting the heating and cooling module is fixedly provided at the lower part of the placement plate. A rotating component for supporting the cover component is vertically provided on the upper rear surface of the support plate in a way that allows it to rotate up and down. Horizontal fixing shafts for fixing the cover component are provided on the upper left and right sides of the support plate. The light source module is provided on the placement plate in a way that it is located on the side of the placement slot.

4. The modular simultaneous diagnostic polymerase chain reaction system according to claim 3, characterized in that, A central groove is formed on the inner side of both ends of the handle. A rotating shaft protruding from the outer side of the cover component is inserted into the central groove. The handle is rotatable with the central groove as the center. A guide groove is formed so that a horizontal fixed shaft provided on the upper surface of the support plate and protruding toward the upper surface of the main body shell is inserted and moved. The guide groove is formed to open downward when the handle is rotated upward and vertically upright, and to lock the horizontal fixed shaft so that it cannot be disengaged when the handle is rotated downward and horizontally laid down.

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