Temperature Measurement Method, Device, Circuit and Blood Glucose Meter Device for Blood Glucose Detection

Abstract

The present invention discloses a temperature measurement method, device, circuit and blood glucose meter device for blood glucose detection. The method includes: obtaining the sensor temperatures of two temperature sensors deployed on the heat conduction path of the blood glucose meter device; judging whether the heat exchange reaches a steady state according to the change trend of the obtained sensor temperatures; when the heat exchange reaches a steady state, inputting the obtained sensor temperatures into a pre-established steady-state heat transfer model to obtain the ambient temperature; when the heat exchange does not reach a steady state, inputting the obtained sensor temperatures into a pre-established unsteady-state heat transfer model to predict the sensor temperatures when the heat exchange reaches a steady state, and inputting the predicted sensor temperatures at the steady state into the steady-state heat transfer model to predict and obtain the ambient temperature; thus, a reliable ambient temperature can be obtained, and the measurement accuracy of the blood glucose value caused by the temperature measurement error of the ambient temperature can be reduced.

Description

Technical Field

[0001] The present invention relates to the field of blood glucose detection, and particularly to a temperature measurement method, device, circuit and blood glucose meter device for blood glucose detection. Background Art

[0002] The blood glucose meter device product mainly consists of a main board and test strips. The main board is composed of an MCU, a charging chip, a battery, and a temperature sensor. The working principle is that a chemical reaction occurs between the blood drop point on the test strip and the blood, and the MCU detects the value after the chemical reaction, and calculates the blood glucose value of the blood through the algorithm of the software. Currently, the accuracy of the blood glucose values measured by the blood glucose meter device products on the market is about 15%. One of the reasons for the low accuracy is limited by the temperature value required for the reaction between the blood drop point and the blood in the algorithm. The algorithm requires accurate ambient temperature information to correct the result, and this temperature value is currently mainly obtained through a temperature sensor. Generally, the temperature sensor is placed beside the test strip port, and the temperature sensor is easily affected by the heat conducted by the heat-generating device through the PCB. Especially for some high-end blood glucose meter devices with complex functions and large heat generation during operation, the heat is conducted to the temperature measurement sensor through the PCB board, resulting in the measured ambient temperature being 2°C to 4°C higher than the actual temperature. Therefore, due to the temperature measurement error, the accuracy of the blood glucose values measured by the blood glucose meter device products on the market is not high. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a temperature measurement method, device, circuit and blood glucose meter device for blood glucose detection in view of the above-mentioned defects of the prior art.

[0004] The technical solution adopted by the present invention to solve its technical problems is as follows:

[0005] On the one hand, a temperature measurement method for blood glucose detection is constructed, and the method includes:

[0006] Obtain the sensor temperatures of two temperature sensors deployed on the heat conduction path of the blood glucose meter device;

[0007] Judge whether the heat exchange reaches a steady state according to the change trend of the obtained sensor temperatures;

[0008] When the heat exchange reaches a steady state, input the obtained sensor temperatures into a pre-established steady-state heat transfer model to obtain the ambient temperature;

[0009] When the heat exchange does not reach a steady state, input the obtained sensor temperatures into a pre-established unsteady-state heat transfer model to predict the sensor temperatures when the heat exchange reaches a steady state, and input the predicted sensor temperatures at the steady state into the steady-state heat transfer model to predict and obtain the ambient temperature.

[0010] Preferably, among the two temperature sensors, one temperature sensor is arranged close to the heat source, and the other temperature sensor is arranged close to the test strip port.

[0011] Preferably, the steady-state heat transfer model is the following calculation formula:

[0012] T amb = T BGM - C * (T Inside - T BGM );

[0013] Wherein, T amb is the ambient temperature, T BGM is the sensor temperature of the temperature sensor arranged close to the test strip port, T Inside is the sensor temperature of the temperature sensor arranged close to the heat source, and C is a constant.

[0014] Preferably, the unsteady-state heat transfer model is the following calculation formula:

[0015]

[0016] Wherein, T0 is the sensor temperature obtained for the first time, T n is the currently obtained sensor temperature, T ∞ is the predicted sensor temperature when the heat exchange reaches the steady state, Δt is the time difference between T0 and T n , and β is a constant. The β corresponding to the two sensors can be the same or different.

[0017] Preferably, the method further includes: processing the continuously obtained ambient temperature by means of moving average to obtain the ambient temperature participating in the calculation of blood glucose concentration.

[0018] Preferably, the method further includes: for the two sensor temperatures newly obtained each time, if it is determined that the data fluctuation is caused by the ambient temperature, the window of the moving average is reduced.

[0019] Preferably, the method further includes: for the two sensor temperatures newly obtained each time, if the change rates of the two sensor temperatures are the same, it is considered that the data fluctuation is caused by the ambient temperature.

[0020] On the other hand, a temperature measuring device for blood glucose detection is constructed, including a processor and a memory. The memory stores a computer program, and when the computer program is executed by the processor, the steps of the method described in any one of the preceding items are implemented.

[0021] In a third aspect, a blood glucose detection circuit is constructed, which includes a controller and two temperature sensors arranged by a heat source and by a test strip port. The controller is configured to execute the steps of the method described in any of the previous items to obtain the ambient temperature in real time, and calculate the blood glucose concentration based on the ambient temperature obtained in real time.

[0022] In a fourth aspect, a blood glucose meter device is constructed, which includes a device body provided with a test strip port and a circuit board arranged inside the device body. The blood glucose detection circuit described above is arranged on the circuit board.

[0023] The temperature measurement method, device, circuit and blood glucose meter device for blood glucose detection of the present invention have the following beneficial effects: Before calculating blood glucose, the present invention does not directly use the data of the temperatures of the two sensors as the ambient temperature to participate in blood glucose calculation, but takes into account the influence of heat conduction on temperature. When the heat exchange reaches a steady state, the obtained sensor temperatures are input into a pre-established steady-state heat transfer model to obtain the ambient temperature; when the heat exchange does not reach a steady state, the obtained sensor temperatures are input into a pre-established unsteady-state heat transfer model to predict the sensor temperatures when the heat exchange reaches a steady state, and the predicted sensor temperatures at steady state are input into the steady-state heat transfer model to predict and obtain the ambient temperature. In this way, a reliable ambient temperature can be obtained, reducing the inaccuracy of blood glucose value measurement caused by the temperature measurement error of the ambient temperature. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained according to the provided drawings:

[0025] Figure 1 is a flowchart of Embodiment 1 of the temperature measurement method for blood glucose detection of the present invention;

[0026] Figure 2 is a schematic internal view of the blood glucose meter device;

[0027] Figure 3 is a schematic deployment view of two temperature sensors;

[0028] Figure 4 is a graph showing the change of temperature with time when the blood glucose meter device is heating up and cooling down;

[0029] Figure 5 is a flowchart of Embodiment 2 of the temperature measurement method for blood glucose detection of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0030] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Typical embodiments of the present invention are shown in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the disclosure of the present invention more thorough and comprehensive.

[0031] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there can also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which the present invention belongs. The terms used in the description of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0032] The general idea of the present invention is as follows: Obtain the sensor temperatures of two temperature sensors deployed on the heat conduction path of the blood glucose meter device; judge whether the heat exchange reaches a steady state according to the change trend of the obtained sensor temperatures; when the heat exchange reaches a steady state, input the obtained sensor temperatures into a pre-established steady-state heat transfer model to obtain the ambient temperature; when the heat exchange does not reach a steady state, input the obtained sensor temperatures into a pre-established unsteady-state heat transfer model to predict the sensor temperatures when the heat exchange reaches a steady state, and input the predicted sensor temperatures at the steady state into the steady-state heat transfer model to predict and obtain the ambient temperature; calculate the blood glucose concentration based on the obtained ambient temperature.

[0033] To better understand the above technical solution, the above technical solution will be described in detail below in conjunction with the specification drawings and specific implementation manners. It should be understood that the embodiments of the present invention and the specific features in the embodiments are detailed descriptions of the technical solution of the present application, rather than limitations on the technical solution of the present application. Without conflict, the technical features in the embodiments of the present invention and the embodiments can be combined with each other.

[0034] Embodiment 1

[0035] Reference Figure 1 , the temperature measurement method for blood glucose detection in this embodiment includes:

[0036] S1: Obtain the sensor temperatures of two temperature sensors deployed on the heat conduction path of the blood glucose meter device.

[0037] Reference Figure 2, the blood glucose meter device has a test strip port. Inside the blood glucose meter device, there are many circuit structures, such as a blood glucose module 3, a WiFi module 4, a Bluetooth module 5, a 4G module 6, a CPU 7, a battery management chip 8, a touch screen 9, a battery 10, an LCD screen backlight 11, etc. The execution subject of the method in this embodiment is the processor of the CPU. The heat in the blood glucose meter device is mainly generated by the battery 10, the CPU 7, the 4G module 6, the WiFi module 4, the LCD screen backlight 11, etc., and diffuses from the middle and lower part to the top (the test strip port is set at the top) in a conduction manner.

[0038] Existing blood glucose meter devices generally only have one temperature sensor 2 set near the test strip port, such as a thermistor, and directly use the temperature of this sensor 2 as the ambient temperature to participate in blood glucose calculation. In the present invention, the ambient temperature during the heat exchange between the device and the outside is deduced by deploying two temperature sensors 2 and 12 on the heat conduction path of the blood glucose meter device. One of the temperature sensors 12 is close to the heat source (specifically, a position with more heat can be selected according to experience) and is easily affected by the heat source. The other temperature sensor 2 is the same as in the prior art and is set near the test strip port for the purpose of easily detecting the ambient temperature. When the circuit board in the blood glucose meter device generates heat, the two temperature sensors 2 and 12 have a certain thermal resistance relationship, and there is a good heat insulation design between the two temperature sensors 2 and 12. As Figure 3 shown, the two temperature sensors 2 and 12 are separated by a partition, and the partition forms two cavities, and the temperature sensors 2 and 12 are distributed in the two cavities.

[0039] It can be understood that the measurement process of the blood glucose meter is continuous, so the temperature sensor will sample periodically to obtain sampling data. Each time a new sensor temperature is obtained, a round of the method steps of the present invention needs to be executed. In order to be able to quickly respond to the ambient temperature, the sampling frequency of the sensor can be increased, but too high a frequency may cause waste of resources and introduce some unnecessary interferences. Considering that the ambient temperature does not change suddenly but changes continuously with time due to heat transfer, the sampling period can be adjusted between 2 s and 1 min according to needs. In this embodiment, a sampling period of 5 s is adopted.

[0040] S2: Judge whether the heat exchange reaches a steady state according to the change trend of the acquired sensor temperature;

[0041] The heat exchange reaching a steady state means that the heat generated inside the device is equal to the heat diffused to the outside. At this time, the temperatures of each test point inside the device do not change with time. The non-steady state means that a stable heat transfer relationship has not been established between the inside of the device and the outside, and the temperatures of each point will change with time, as Figure 4 shown. In the figure, T amb is the ambient temperature, T BGMis the sensor temperature of the temperature sensor set by the test strip port, T Inside is the sensor temperature of the temperature sensor set by the heat source.

[0042] Specifically, the change trend of the sensor temperature can be represented by the rate of change of the sensor temperature over time. A threshold range [k1, -k1] can be set. If the rate of change is within the threshold range, it is considered that the exchange has reached a steady state; otherwise, it is considered that the exchange is in an unsteady state.

[0043] S3: When the heat exchange reaches a steady state, input the obtained sensor temperature into the pre-established steady-state heat transfer model to obtain the ambient temperature;

[0044] The heat transfer inside the blood glucose meter device mainly occurs in a conduction manner. Among them, the steady-state heat transfer model is the following calculation formula:

[0045] T amb =T BGM -C*(T Inside -T BGM ) (1);

[0046] Among them, T amb is the ambient temperature, T BGM is the sensor temperature of the temperature sensor set by the test strip port, T Inside is the sensor temperature of the temperature sensor set by the heat source, and C is a constant. After the product structure is finalized, the constant C can be measured through multiple experiments. For example, before the device is put into use, place it in a temperature chamber (set to 5°C, 17°C, 25°C, 33°C, 45°C in sequence), let the device keep heating until the heat exchange reaches a stable state, and use a temperature measurement device to monitor the ambient temperature at the blood dripping point in real time. The temperatures actually collected by the two temperature sensors 2 and 12 will be about 3°C higher than the ambient temperature. The value of C can be simulated using the above calculation formula (1) and written into the memory of the CPU of the device. After the device is put into use later, the processor of the device CPU will substitute T BGM and T Inside into the above calculation formula (1) to calculate T amb . The ambient temperature predicted by the above calculation formula (1) is very close to the real ambient temperature, and the accuracy is within ±1°C.

[0047] S4: When the heat exchange has not reached a steady state, input the obtained sensor temperature into the pre-established unsteady-state heat transfer model to predict the sensor temperature when the heat exchange reaches a steady state, and input the predicted sensor temperature at the steady state into the steady-state heat transfer model to predict the ambient temperature;

[0048] Among them, the unsteady-state heat transfer model is the following calculation formula:

[0049]

[0050] Among them, T0 is the sensor temperature obtained for the first time, T n is the currently obtained sensor temperature, T ∞ is the sensor temperature when the predicted heat exchange reaches a steady state, and Δt is the time difference between T0 and T n . β is a constant related to the structure and materials of the blood glucose meter. The β values corresponding to the two sensors can be the same or different, and β can also be determined through experiments. For example, in a temperature chamber, control the heating state of the device to increase or decrease the internal temperature of the machine. The temperatures actually collected by the two temperature sensors 2 and 12 are rising or falling, and use a temperature measuring device to monitor the temperature of the blood dripping point in real time. The value of β can be simulated using the above calculation formula (2) and written into the memory of the CPU of the device. After the subsequent device is put into use, the processor of the device CPU will substitute T BGM and T Inside into the above calculation formula (2) to calculate T amb . The ambient temperature predicted by the above calculation formula (2) is very close to the actual ambient temperature, with an accuracy within ±1°C.

[0051] It can be understood that substituting the sensor temperatures obtained from the two temperature sensors 2 and 12 into the above calculation formula (2) respectively gives:

[0052]

[0053]

[0054] Among them, T s_BGM and T s_Inside are the sensor temperatures of sensors 2 and 12 when the predicted heat exchange reaches a steady state; T BGM0 and T Inside0 are the sensor temperatures of sensors 2 and 12 obtained for the first time; T BGMn and T Insiden are the currently obtained sensor temperatures of sensors 2 and 12; β BGM and β Inside correspond to sensors 2 and 12 respectively and are determined through pre-experiments. Δt is the time difference between T BGM0 and T BGMn , and is also the time difference between T Inside0 and T Insiden .

[0055] After obtaining T s_BGM and T s_Inside , substituting them into calculation formula (1) gives:

[0056] T amb = TS_BGM -C*(T S_Inside -T S_BGM );

[0057] Based on the obtained ambient temperature, the blood glucose concentration can be calculated. Using the ambient temperature to participate in the calculation of the blood glucose concentration is the prior art and is not the focus of the present invention, so it will not be elaborated here.

[0058] Embodiment 2

[0059] Theoretically, the calculated ambient temperature can be directly used for the calculation of the blood glucose concentration. In this embodiment, based on the theory that the ambient temperature does not mutate, in this embodiment, referring to Figure 5 , the method further includes:

[0060] S5: Process the periodically calculated ambient temperature by means of moving average to obtain the sensor temperature for subsequent calculation.

[0061] For example, assuming that the window of the moving average is 5 sampling periods in length, then the ambient temperatures calculated by steps S3 / S4 for the 1st - 5th are accumulated and averaged to obtain the first ambient temperature for blood glucose concentration calculation, and the ambient temperatures calculated by steps S3 / S4 for the 2nd - 6th are accumulated and averaged to obtain the second ambient temperature for blood glucose concentration calculation, and so on.

[0062] The change of the ambient temperature or the change of the internal heat generation will cause data fluctuations and affect the prediction result. Before performing the smoothing filtering process, it is necessary to distinguish the change state.

[0063] Furthermore, step S5 further includes: before the moving average, for the two sensor temperatures newly obtained in step S1, compare the change rates of the two sensor temperatures. If the change rates of the two sensor temperatures are the same, such as rising or falling at the same rate, it is determined that the data fluctuation is caused by the ambient temperature, and then the window of the moving average is reduced to quickly respond to the change of the external temperature..

[0064] Among them, the change rate of the sensor temperature is obtained by dividing the difference between the current sensor temperature and the previous sensor temperature by the time difference between them (i.e., the time length of the sampling period).

[0065] If the data change is not caused by the ambient temperature, generally the change rate of the sensor temperature of the sensor close to the heat source is larger than the change rate of the sensor temperature of the sensor close to the test strip port, then it is considered that the fluctuation is caused by the change of the internal heat generation. At this time, the ambient temperature has not changed significantly, and the window size of the moving average remains unchanged, that is, a larger window is still used to smooth the ambient temperature calculated by steps S3 / S4.

[0066] Embodiment 3

[0067] This embodiment discloses a temperature device for blood glucose detection, including a processor and a memory. For example, the blood glucose detection device can be a CPU. The memory stores a computer program, and when the computer program is executed by the processor, it realizes the steps of the method in Embodiment 1 or Embodiment 2. The specific implementation process can refer to the description of the above method embodiments and will not be elaborated here.

[0068] Embodiment 4

[0069] This embodiment discloses a blood glucose detection circuit, including a controller and two temperature sensors arranged near the heat source and near the test strip port. For example, the controller can be a CPU. The controller is used to execute the steps of the method in Embodiment 1 or Embodiment 2 to obtain the ambient temperature in real time and calculate the blood glucose concentration based on the ambient temperature obtained in real time. The specific implementation process can refer to the description of the above method embodiments and will not be elaborated here.

[0070] Embodiment 5

[0071] This embodiment discloses a blood glucose meter device, including a device body with a test strip port and a circuit board arranged inside the device body. The blood glucose detection circuit described in Embodiment 3 is arranged on the circuit board.

[0072] In summary, the temperature measurement method, device, circuit, and blood glucose meter device for blood glucose detection of the present invention have the following beneficial effects: Before calculating blood glucose, the present invention does not directly use the temperature data of the two sensors as the ambient temperature to participate in blood glucose calculation, but takes into account the influence of heat conduction on temperature. When the heat exchange reaches a steady state, the sensor temperature obtained is input into a pre-established steady-state heat transfer model to obtain the ambient temperature; when the heat exchange does not reach a steady state, the sensor temperature obtained is input into a pre-established unsteady-state heat transfer model to predict the sensor temperature when the heat exchange reaches a steady state, and the predicted steady-state sensor temperature is input into the steady-state heat transfer model to predict and obtain the ambient temperature. In this way, a reliable ambient temperature can be obtained, reducing the inaccuracy of blood glucose value measurement caused by the temperature measurement error of the ambient temperature.

[0073] The embodiments of the present invention have been described above in conjunction with the accompanying drawings. However, the present invention is not limited to the above specific embodiments. The above specific embodiments are merely illustrative and not restrictive. Under the inspiration of the present invention, those of ordinary skill in the art can also make many forms without departing from the spirit and scope protected by the claims of the present invention. These all fall within the protection scope of the present invention.

Claims

1. A temperature measurement method for blood glucose detection, characterized in that, The method includes: Obtaining the sensor temperatures of two temperature sensors deployed on the heat conduction path of the blood glucose meter device. Among the two temperature sensors, one temperature sensor is arranged close to the heat source, and the other temperature sensor is arranged close to the test strip port; Judging whether the heat exchange reaches a steady state according to the change trend of the obtained sensor temperatures; the change trend of the sensor temperatures is represented by the change rate of the sensor temperatures over time. If the change rate is within the threshold range, it is considered that the exchange reaches a steady state, otherwise it is considered that the exchange is in an unsteady state; When the heat exchange reaches a steady state, input the obtained sensor temperatures into a pre-established steady-state heat transfer model to obtain the ambient temperature; When the heat exchange does not reach a steady state, input the obtained sensor temperatures into a pre-established unsteady-state heat transfer model to predict the sensor temperatures when the heat exchange reaches a steady state, and input the predicted sensor temperatures at the steady state into the steady-state heat transfer model to predict the ambient temperature.

2. The temperature measurement method for blood glucose detection according to claim 1, wherein The steady-state heat transfer model is the following calculation formula: T amb = T BGM - C * (T Inside - T BGM ); Among them, T amb is the ambient temperature, T BGM is the sensor temperature of the temperature sensor set near the test strip opening, T Inside is the sensor temperature of the temperature sensor set near the heat source, and C is a constant.

3. The temperature measurement method for blood glucose detection according to claim 1, wherein The unsteady-state heat transfer model is the following calculation formula: Among them, T0 is the sensor temperature obtained for the first time, T n is the currently obtained sensor temperature, T ∞ is the sensor temperature when the predicted heat exchange reaches a steady state, Δt is the time difference between T0 and T n and β is a constant. The β values corresponding to the two sensors can be the same or different.

4. The temperature measurement method for blood glucose detection according to claim 1, characterized in that, The method further includes: processing the continuously obtained ambient temperatures in a moving average manner to obtain the ambient temperature participating in the calculation of the blood glucose concentration.

5. The temperature measurement method for blood glucose detection according to claim 4, wherein The method further includes: For each newly obtained temperatures of the two sensors, if it is judged that the data fluctuation is caused by the ambient temperature, then reduce the window of the moving average.

6. The temperature measurement method for blood glucose detection according to claim 5, characterized in that, The method further includes: for each newly obtained temperatures of the two sensors, if the change rates of the two sensor temperatures are the same, it is considered that the data fluctuation is caused by the ambient temperature.

7. A temperature measuring device for blood glucose detection, characterized in that, It includes a processor and a memory. The memory stores a computer program. When the computer program is executed by the processor, the steps of the method according to any one of claims 1-6 are implemented.

8. A blood glucose detection circuit, characterized in that, It includes a controller and two temperature sensors arranged close to the heat source and close to the test strip port. The controller is used to execute the steps of the method according to any one of claims 1-6 to obtain the ambient temperature in real time, and calculate the blood glucose concentration based on the ambient temperature obtained in real time.

9. A blood glucose meter device, characterized in that, It includes a device body provided with a test strip port and a circuit board arranged in the device body. The blood glucose detection circuit according to claim 8 is arranged on the circuit board.

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