A water temperature and flow detection device for water bath sterilization of large infusion products

Abstract

The present invention discloses a water bath sterilization water distribution temperature and flow detection device for large infusion products, which belongs to the field of medicine bottle sterilization technology. It comprises: a sterilizer, wherein a sterilization cavity is provided in the sterilizer; a sterilization rack, wherein the sterilization rack is slidably arranged in the sterilization cavity; a water distribution system, which is arranged above the sterilization cavity and is used to spray and sterilize the products on the sterilization rack; a circulating water constant pressure system, wherein the circulating water constant pressure system is arranged above the sterilizer and is connected to the water distribution system; a temperature uniformity device, wherein the temperature uniformity device is arranged on the circulating water constant pressure system; a water distribution temperature and flow detection system, wherein the water distribution temperature and flow detection system is installed in the sterilization rack and is located below the water distribution system, and is used to detect the flow and temperature of water in the sterilization cavity. By using multiple water collectors and multiple ultrasonic flowmeters under the same measurement conditions, the water flow and temperature changes of multiple medicines flowing through the container surface per unit time can be accurately obtained.

Description

Technical Field

[0001] The present invention relates to the technical field of medicine bottle sterilization, and more particularly to a water temperature and flow detection device for water bath sterilization of large infusion products. Background Art

[0002] Infusion is one of the most widely used and important clinical treatments. Medication enters the bloodstream directly through the veins, making its sterility crucial for safe use. Sterility in large-volume infusions is typically achieved through microbial sterilization, with autoclaving being the dominant sterilization method in the industry.

[0003] The most commonly used autoclave sterilization method is to sterilize medicine bottles with "superheated water" heated by steam or other media under a certain pressure to kill microorganisms. This method has been widely adopted by the pharmaceutical industry due to its temperature uniformity, controllability, and economical medium. The method of using "superheated water" to kill microorganisms is called water bath sterilization.

[0004] Water bath sterilization has an advantage over other sterilization methods due to its temperature uniformity. However, in the actual sterilization process of medicine bottles, this temperature uniformity is also relative. Medicine bottles sterilized with "superheated water" in the same sterilizer will also exhibit different physical and chemical properties due to temperature differences. The fundamental reason for these different properties is mainly reflected in the uneven amount of water and uneven water temperature showered on the medicine bottles.

[0005] This temperature difference has a particularly significant impact on the sterilization quality of heat-sensitive medicine bottles. The Chinese patent application number for "A Water Bath Sterilization Temperature and Pressure Uniform Water Distribution System," CN202011372941.X, only examines the uniform temperature and pressure distribution of water during water bath sterilization, without examining the flow rate and temperature of the water reaching the bottles at different locations.

[0006] At present, the temperature uniformity of each point in the water bath sterilizer is generally tested in China by using dense probes, usually one probe per cubic meter. This measurement is relatively rough and cannot be precise enough to measure the location of each medicine bottle. Summary of the Invention

[0007] The purpose of the present invention is to provide a water temperature and flow detection device for water bath sterilization of large infusion products, in order to solve the technical problems existing in the background technology.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] A water temperature and flow detection device for water bath sterilization of large infusion products, characterized by comprising:

[0010] A sterilizer, wherein a sterilization cavity is provided in the sterilizer;

[0011] A sterilization rack, the sterilization rack being slidably disposed in the sterilization cavity;

[0012] A water distribution system is provided above the sterilization chamber and is used to spray and sterilize the products on the sterilization rack;

[0013] A circulating water constant pressure system, which is arranged above the sterilizer and connected to the water distribution system;

[0014] A temperature uniformity device, which is arranged on the circulating water constant pressure system;

[0015] The water distribution temperature and flow detection system is installed in the sterilization rack and located below the water distribution system, and is used to detect the flow and temperature of water in the sterilization chamber.

[0016] In some embodiments, the water distribution temperature and flow detection system includes:

[0017] A measuring water platform, which is installed on the sterilization rack;

[0018] A measuring platform, wherein the measuring platform is slidably connected to the measuring horizontal platform;

[0019] Water collection and temperature measuring devices, a plurality of which are arranged on the measuring platform; and located below the water distribution system.

[0020] In some embodiments, the water collection and temperature measuring device comprises:

[0021] A pillar, wherein a hollow mounting cavity is provided in the pillar;

[0022] an open funnel, the open funnel being arranged in the mounting cavity;

[0023] a liquid collecting pipe, the liquid collecting pipe being arranged in the installation cavity, and the top of the liquid collecting pipe being sealedly connected to the lower part of the open funnel;

[0024] A reducing pipe is arranged in the installation cavity, and the top of the reducing pipe is sealedly connected to the lower part of the collecting pipe;

[0025] A water flow conduit, the water flow conduit being sealedly connected to the lower portion of the variable diameter pipe;

[0026] an ultrasonic flow meter connected to the water flow conduit;

[0027] a temperature probe, one end of which is disposed in the collecting pipe and the other end of which is disposed outside the support;

[0028] A control box, the control box being communicatively connected to the temperature probe and the ultrasonic flow meter respectively;

[0029] Among them, the bottom diameter of the open funnel is greater than the bottom diameter of the collecting pipe and greater than the bottom diameter of the reducing pipe.

[0030] In some embodiments, the measuring platform is slidably connected to the measuring horizontal platform through a control component, and the control component includes a servo motor, a synchronous belt, a movable balance guide rod, and a synchronous belt cluster wheel. One end of the synchronous belt is sleeved on the driving wheel of the servo motor, and the other end of the synchronous belt is sleeved on the synchronous belt cluster wheel installed on the measuring horizontal platform. The movable balance guide rod is set on the measuring horizontal platform, and the measuring platform is slidably sleeved on the movable balance guide rod; the synchronous belt is fixedly connected to the measuring platform.

[0031] In some embodiments, the diameter of the open funnel is the same as the largest cross-section of the vial.

[0032] Furthermore, the water bath sterilization temperature and pressure uniform water distribution system also includes: a heating heat exchange device and a cooling heat exchange device respectively connected to the temperature uniform device.

[0033] Furthermore, the water distribution system includes: a constant pressure pipe in the cabinet, which is connected to the water outlet of the circulating water constant pressure system; a diversion pipe, and multiple diversion pipes are connected to the constant pressure pipe in the cabinet at equal intervals; a water distribution tray: multiple water distribution trays are arranged on the top of the sterilization chamber, and each water distribution tray is provided with a water storage chamber, and a plurality of first leakage holes are provided at the bottom of the water storage chamber, and each water distribution tray corresponds to a diversion pipe; a retaining ring, which is arranged at the bottom of the water storage chamber, and the diversion pipe is arranged in the retaining ring.

[0034] Furthermore, the diverter pipe is U-shaped, the middle part of the diverter pipe is connected to the constant pressure pipe in the cabinet, each water distribution tray is provided with two retaining rings, the two ends of the U-shaped diverter pipe are respectively arranged in the retaining rings, and flow regulating discs are respectively provided at the two ends of the diverter pipe.

[0035] Furthermore, the circulating water constant pressure system includes: a balancing pipe, the inlet of the balancing pipe is connected to the water outlet of the temperature uniformization device; a constant pressure tank, the water inlet of the constant pressure tank is connected to the outlet of the balancing pipe; a constant pressure pipe outside the cabinet, the water outlet of the constant pressure tank is connected to the constant pressure pipe outside the cabinet, and the constant pressure pipe outside the cabinet is connected to the constant pressure pipe inside the cabinet through a connecting pipe, and the connecting pipe is sealed and fixed on the side wall of the sterilizer.

[0036] Furthermore, the balancing pipe and the constant pressure tank are each provided with two parts, and are symmetrically arranged on both sides of the temperature uniform device; the diameter of the balancing pipe is arranged from large to small from the end far away from the constant pressure tank to the end close to the constant pressure tank.

[0037] Furthermore, the temperature uniformization device includes: a temperature controller, which is respectively arranged on the constant pressure tank; a temperature balancing device, which is arranged on the balancing pipe; and a mixing pipe, the water outlet end of the mixing pipe is respectively connected to the water inlet of the two balancing pipes.

[0038] Furthermore, the heating and heat exchange device includes a heating heat exchanger and a first water pump, the water inlet of the first water pump is connected to the bottom of the sterilizer, the water outlet of the first water pump is connected to the water inlet of the heating heat exchanger, and the water outlet of the heating heat exchanger is connected to the water inlet of the mixing pipe.

[0039] Furthermore, the refrigeration and heat exchange device includes a refrigeration and heat exchanger and a second water pump, the water inlet of the second water pump is connected to the bottom of the sterilizer, the water outlet of the second water pump is connected to the water inlet of the refrigeration and heat exchanger, and the water outlet of the refrigeration and heat exchanger is connected to the water inlet of the mixing pipe.

[0040] Furthermore, the sterilization rack includes: a plurality of stacked sterilization boxes, a placement cavity is provided in the sterilization boxes, the bottom of the sterilization box has a hollow interlayer, the top wall of the hollow interlayer is provided with a plurality of penetrating second leakage holes, the bottom wall of the hollow interlayer is provided with a plurality of penetrating third leakage holes, and the aperture of the second leakage hole is larger than the aperture of the third leakage hole.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] The present invention provides a water bath sterilization water distribution temperature and flow detection device for large infusion products. After the circulating water is processed by a heating heat exchanger and a cooling heat exchanger, it passes through a temperature equalization device to achieve relatively uniform water temperature at the same time. After passing through a balancing pipe with a gradually decreasing diameter, the flow rate at the minimum pipe diameter is guaranteed, so that the water pressure in the constant pressure tank is at a constant pressure. After the pressure is balanced again by a secondary constant pressure pipe (inside and outside the cabinet), the water pressure flowing into the shunt pipe is balanced. Then, through fine adjustment of the flow regulating disc at the water outlet end of the shunt pipe, the water flow into the water distribution pan of each shunt pipe is ensured to be equal at the same time. At the same time, the water temperature difference in each constant pressure tank can be adjusted by the temperature balancing device. Ultimately, the flow rate and temperature of the circulating water flowing into the water distribution pan are uniform at the same time.

[0043] The circulating water flowing into the water distribution tray is then used to shower-heat (cool) the regularly arranged medicine bottles loaded in the sterilization box through the first water leakage holes with the same aperture evenly distributed on the water distribution tray. The circulating water flowing through the surface of the medicine bottles then flows through the larger second water leakage holes in the upper layer of the sterilization box to form a water distribution level in the interlayer of the sterilization box, and is shower-heated (cooled) to the medicine bottles in the next layer through the smaller third water leakage holes in the bottom layer of the sterilization box. Ultimately, a batch of medicine bottles can be heated (cooled) more uniformly in the same time period, and the sterility level, physical and chemical properties of the products can be consistent.

[0044] The circulating water in a water bath sterilizer is pumped through a designed pipeline, heated (cooled) by a heat exchanger, and then flows through various pipes and devices into a water distribution tray. The circulating water in the water distribution tray then flows through holes of uniform diameter evenly distributed on the water distribution tray to shower heat (cool) the regularly arranged drugs loaded in the sterilization box. During measurement, the sterilization process is followed to ensure that the circulating water in the cabinet reaches a certain temperature and the pump frequency is maintained at a fixed level for a period of time to avoid detection errors caused by changes in the flow rate and temperature of the circulating water in the cabinet.

[0045] The cross-sectional shape and position of the water collection and temperature detector align with the position of the medicines within the cabinet, ensuring that the amount of water flowing through the medicines at any given time is consistent with the amount flowing into the water collection and temperature detector. Water flowing into the water collector passes through an open funnel, converges at a reducer, and flows through a Class A temperature probe for timely temperature measurement. The sterilizer's circulating water, having undergone temperature measurement, then passes through a water conduit and an ultrasonic flowmeter for water volume measurement per unit time. After the programmed collection time has expired, the system moves one medicine bottle apart to measure the water flow rate and temperature flowing through the second row of medicine bottles. This reciprocating movement continues until all the medicine bottles have been tested.

[0046] In this way, the water flow rate and temperature change of multiple medicine bottles flowing through the container surface per unit time can be accurately obtained under the same measurement conditions through multiple water collectors and multiple ultrasonic flow meters.

[0047] The purpose of the water flow rate and temperature measurement methods for water bath sterilization equipment is to detect differences in water flow and temperature along the outer surfaces of individual medicine bottles and indicate these differences so that engineers can adjust these water distribution points. Ultimately, this ensures consistent sterility levels, physical, and chemical properties across the entire batch of medicines. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 It is a schematic diagram of a water temperature and flow detection device for water bath sterilization of large infusion products of the present invention.

[0049] Figure 2 It is a structural schematic diagram of the sterilization chamber of the present invention.

[0050] Figure 3 It is a connection diagram of the water distribution system and the circulating water constant pressure system of the present invention.

[0051] Figure 4 It is a schematic diagram of the connection between the water distribution tray and the retaining ring of the present invention.

[0052] Figure 5 It is a schematic diagram of the connection between the water distribution tray and the diversion pipe of the present invention.

[0053] Figure 6It is a schematic diagram of the connection between the flow regulating disc and the shunt pipe of the present invention.

[0054] Figure 7 It is a structural schematic diagram of the sterilization box of the present invention.

[0055] Figure 8 It is a structural schematic diagram of the water distribution temperature and flow detection system of the present invention.

[0056] Figure 9 It is a structural schematic diagram of the water collection and temperature measuring device of the present invention.

[0057] Markings in the figure: 1-sterilizer, 2-heating heat exchanger, 3-constant pressure tank, 4-balancing pipe, 5-constant pressure pipe outside the cabinet, 6-first water pump, 7-refrigeration heat exchanger, 8-water distribution tray, 9-diverter pipe, 10-temperature controller, 11-temperature balancing device, 12-mixing pipe, 13-flow regulating disc, 14-retaining ring, 15-sterilization chamber, 16-sterilization rack, 17-medicine bottle, 18-constant pressure pipe in the cabinet, 19-circulating water pipe in the cabinet, 20-second water pump, 21-first leakage hole, 22-sterilization box, 23-second leakage Water hole, 24-third leakage hole, 25-hollow interlayer, 26-water distribution temperature and flow detection system, 27-water collection temperature detector, 28-data line, 29-water flow conduit, 30-ultrasonic flowmeter, 31-servo motor, 32-servo motor driving wheel, 33-synchronous belt, 34-synchronous belt cluster wheel, 35-position sensor, 36-measuring platform, 37-movable balance guide rod, 38-measuring water platform, 39-control box, 40-open leak head, 41-liquid collecting pipe, 42-temperature probe, 43-variable pipe. DETAILED DESCRIPTION

[0058] In order to make the purpose, technical solutions and advantages of the present application clearer, the technical solutions in the embodiments of the present application will be described in more detail below in conjunction with the drawings in the preferred embodiments of the present application. In the drawings, the same or similar reference numerals throughout represent the same or similar parts or parts with the same or similar functions. The described embodiments are part of the embodiments of the present application, not all of the embodiments. The embodiments described below with reference to the drawings are exemplary and are intended to be used to explain the present application, and should not be understood as limitations on the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0059] The embodiments of the present application are described in detail below with reference to the accompanying drawings.

[0060] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they may refer to a fixed connection, an indirect connection via an intermediate medium, internal communication between two components, or an interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on the specific circumstances.

[0061] In the description of this application, it should be understood that the terms "upper", "lower", "front", "back", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are orientations or positional relationships based on the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on this application.

[0062] In addition, the terms "comprises" and "having" and any variations thereof are intended to cover a non-exclusive inclusion, for example, a process, method, system, product or display that includes a series of steps or elements is not necessarily limited to those steps or elements expressly listed but may include other steps or elements not expressly listed or inherent to such process, method, product or display.

[0063] The following will be combined Figure 1-9 , a water temperature and flow detection device for a large infusion product water bath sterilization cloth involved in the embodiment of the present application is described in detail. It is worth noting that the following embodiments are only used to explain the present application and do not constitute a limitation of the present application.

[0064] Embodiment 1:

[0065] like Figure 1-9 As shown, a water distribution temperature and flow detection device for water bath sterilization of large infusion products includes: a sterilizer 1, a sterilization chamber 15 is provided in the sterilizer 1; a sterilization rack 16, the sterilization rack 16 is slidably arranged in the sterilization chamber 15; a water distribution system, arranged above the sterilization chamber 15, for spraying and sterilizing the products on the sterilization rack 16; a circulating water constant pressure system, the circulating water constant pressure system is arranged above the sterilizer 1 and connected to the water distribution system; a temperature uniformity device, the temperature uniformity device is arranged on the circulating water constant pressure system; a water distribution temperature and flow detection system 26, the water distribution temperature and flow detection system 26 is installed in the sterilization rack 16 and is located below the water distribution system, for detecting the flow and temperature of water in the sterilization chamber 15.

[0066] In some embodiments, the water distribution temperature and flow detection system 26 includes: a measuring platform 38 mounted on the sterilization rack 16; a measuring platform 36 slidably connected to the measuring platform 38; and water collection and temperature sensors 27, multiple of which are mounted on the measuring platform 36 and located below the water distribution system. A position sensor 35 is provided on one side of the measuring platform 38.

[0067] The water collection and temperature measuring device 27 includes: a pillar, a hollow installation cavity is provided in the pillar; an open funnel, the open funnel is arranged in the installation cavity; a collecting pipe 41, the collecting pipe 41 is arranged in the installation cavity, and the top of the collecting pipe 41 is sealed and connected to the bottom of the open funnel; a reducing pipe 43, the reducing pipe 43 is arranged in the installation cavity, and the top of the reducing pipe 43 is sealed and connected to the bottom of the collecting pipe 41; a water flow conduit 29, the water flow conduit 29 is sealed and connected to the bottom of the reducing pipe 43; an ultrasonic flowmeter 30, the ultrasonic flowmeter 30 is connected to the water flow conduit 29; a temperature probe 42, one end of the temperature probe 42 is arranged in the collecting pipe 41, and the other end of the temperature probe 42 is arranged outside the pillar; a control box 39, the control box 39 is respectively communicated with the temperature probe 42 and the ultrasonic flowmeter 30; wherein, the bottom diameter of the open funnel is greater than the bottom diameter of the collecting pipe 41 and the bottom diameter of the reducing pipe 43.

[0068] In some embodiments, the measuring platform 36 is slidably connected to the measuring horizontal platform 38 through a control component, and the control component includes a servo motor 31, a synchronous belt 33, a movable balance guide rod 37, and a synchronous belt 33 driving wheel. One end of the synchronous belt 33 is sleeved on the driving wheel of the servo motor 31, and the other end of the synchronous belt 33 is sleeved on the synchronous belt 33 driving wheel installed on the measuring horizontal platform 38. The movable balance guide rod 37 is set on the measuring horizontal platform 38, and the measuring platform 36 is slidably sleeved on the movable balance guide rod 37; the synchronous belt 33 is fixedly connected to the measuring platform 36.

[0069] In some embodiments, the diameter of the open funnel is the same as the largest cross-section of the vial 17.

[0070] like Figure 1-3As shown, in this embodiment, the water distribution system includes: a constant pressure pipe 18 in the cabinet, a diversion pipe 9, a water distribution pan 8, and a retaining ring 14. The constant pressure pipe 18 in the cabinet is connected to the water outlet of the circulating water constant pressure system; multiple diversion pipes 9 are connected to the constant pressure pipe 18 in the cabinet at equal intervals; multiple water distribution pans 8 are arranged at the top of the sterilization chamber 15, and each water distribution pan 8 has a water storage chamber. The bottom of the water storage chamber is provided with a plurality of first water leakage holes 21 with a diameter of approximately 2 mm. Each water distribution pan 8 corresponds to a diversion pipe 9; the retaining ring 14 is arranged at the bottom of the water storage chamber, and the diversion pipe 9 is arranged within the retaining ring 14. The function of the retaining ring 14 is to prevent the circulating water from affecting the water level of the water distribution pan 8. There are two retaining rings 14 with a height of 15-20 mm and a diameter of 30 mm at the geometric center of the water distribution tray 8. The retaining rings 14 are connected to the water distribution tray 8 by welding. The water distribution tray 8 is connected to the inner wall of the sterilization chamber 15 through a bracket. Preferably, the diverter pipe 9 is U-shaped, and the middle part of the diverter pipe 9 is connected to the constant pressure pipe 18 in the cabinet. Two retaining rings 14 are provided on each water distribution tray 8, and the two ends of the U-shaped diverter pipe 9 are respectively arranged in the retaining rings 14, and flow regulating discs 13 are respectively provided at both ends of the diverter pipe 9.

[0071] The relative rotation of the two flow regulating discs 13 can adjust the flux of the shunt pipe 9. The water outlet of the shunt pipe 9 extends 5 mm into the retaining ring 14. The upper end of the shunt pipe 9 is connected to the constant pressure pipe 18 in the cabinet; the shunt pipes 9 are evenly distributed on the constant pressure pipe 18 in the cabinet, and the diameter of the constant pressure pipe 18 in the cabinet is more than twice the diameter of the shunt pipe 9; the upper end of the constant pressure pipe 18 in the cabinet is connected to the constant pressure pipe 5 outside the cabinet through the sterilization cavity 15. The diameter of the constant pressure pipe 5 outside the cabinet is approximately twice the diameter of the constant pressure pipe 18 in the cabinet, and the length is equivalent to that of the constant pressure pipe 18 in the cabinet; the connection between the constant pressure pipe 18 in the cabinet and the constant pressure pipe 5 outside the cabinet is the geometric center of the constant pressure pipe 5 outside the cabinet.

[0072] like Figure 7 As shown, in this embodiment, the sterilization rack 16 includes: a plurality of stacked sterilization boxes 22, each of which has a placement cavity. The bottom of the sterilization box 22 has a hollow interlayer 25. The top wall of the hollow interlayer 25 is provided with a plurality of second leakage holes 23 extending therethrough. The bottom wall of the hollow interlayer 25 is provided with a plurality of third leakage holes 24 extending therethrough. The diameter of the second leakage holes 23 is larger than that of the third leakage holes 24. The height of the hollow interlayer 25 is approximately 8-12 mm, the diameter of the third leakage holes 24 is approximately 2 mm, and the diameter of the second leakage holes 23 is approximately 6-8 mm.

[0073] like Figure 4-6As shown, in this embodiment, the circulating water constant pressure system includes: a balancing pipe 4, the inlet of which is connected to the water outlet of the temperature uniform device; a constant pressure tank 3, the water inlet of which is connected to the outlet of the balancing pipe 4; an external constant pressure pipe 5, the outlet of which is connected to the external constant pressure pipe 5, the external constant pressure pipe 5 is connected to the internal constant pressure pipe 18 via a connecting pipe, and the connecting pipe is sealed and fixed on the side wall of the sterilizer 1. The pipe diameter of the connecting pipe is equivalent to the diameter of the external constant pressure pipe 5. The balancing pipe 4 and the constant pressure tank 3 are both provided with two parts, and are symmetrically arranged on both sides of the temperature uniform device; the diameter of the balancing pipe 4 is arranged from large to small from the end away from the constant pressure tank 3 to the end close to the constant pressure tank 3.

[0074] The diameter of the constant pressure tank 3 is about 3-6 times that of the constant pressure pipe 5 outside the cabinet, and the height is about 4-5 times the diameter of the constant pressure pipe 5 outside the cabinet; a temperature controller 10 is installed on the constant pressure tank 3; the upper end of the constant pressure tank 3 is connected to the balance pipe 4, and the balance pipe 4 is composed of three sections of pipes with successively smaller diameters, and the constant pressure tank 3 is connected to the end with the smallest diameter of the balance pipe 4; the advantage of the three-section design from large to small is that the gas in the circulating water is collected at the large pipe and then buffered by the middle pipe, and the possibility of gas appearing in the circulating water flowing into the small pipe is reduced. At the same time, according to the fluid flow formula, the flow rate in the pipe is reduced. The flow rate Q = S*V; Q (flow rate in the pipeline, in cubic meters per second); S (effective cross-sectional area of ​​the pipeline, in square meters); V (flow velocity of the medium through the pipeline, in meters per second); From the formula, it can be seen that the pipe diameter gradually becomes smaller. When the total circulating water volume is constant, the diameter of the circulating pipeline becomes smaller and the flow rate per unit cross-sectional area increases. The benefit is that: the water pressure is constant (stable output of the circulating pump), and when the flow rate from the mixing water pipe 12 to the balancing pipes 4 on both sides is inconsistent, the flow rate through the small diameter of the balancing pipe 4 per unit time is also relatively consistent.

[0075] In this embodiment, the temperature uniformization device includes: a temperature controller 10, each of which is mounted on the constant pressure tank 3; a temperature balancing device 11, each of which is mounted on the balancing pipe 4; and a mixing pipe 12, the outlet of which is connected to the water inlets of the two balancing pipes 4. The heating and heat exchange device includes a heating heat exchanger 2 and a first water pump 6. The inlet of the first water pump 6 is connected to the bottom of the sterilizer 1, and the outlet of the first water pump 6 is connected to the water inlet of the heating heat exchanger 2. The outlet of the heating heat exchanger 2 is connected to the water inlet of the mixing pipe 12. The cooling and heat exchange device includes a cooling and heat exchanger 7 and a second water pump 20. The inlet of the second water pump 20 is connected to the bottom of the sterilizer 1, preferably to the lowest point of the bottom of the sterilizer 1. The outlet of the second water pump 20 is connected to the water inlet of the cooling and heat exchanger 7. The outlet of the cooling and heat exchanger 7 is connected to the water inlet of the mixing pipe 12.

[0076] The temperature balancing device 11 is wound around the middle section of the balancing pipe 4 and is a double-wound cold (heat) exchange device. The maximum diameter end of the balancing pipe 4 is connected to the mixing pipe 12. The diameter of the mixing pipe 12 is twice the maximum diameter of the balancing pipe 4. The point where the maximum diameter end of the balancing pipe 4 connects to the mixing pipe 12 is located at 1 / 2 of the geometric dimension of the internal mixing pipe 12. The other end of the mixing pipe 12 is connected to the cabinet water circulation pipe through a diameter reducer. The other end of the cabinet water circulation pipe is connected to the cabinet water heat exchanger. The cabinet water pipe is connected to the water inlet of the cooling heat exchanger 7 and the heating heat exchanger 2 respectively. The medium end of the cooling heat exchanger 7 is connected to cooling water, and the medium end of the heating heat exchanger 2 is connected to steam. The water outlets of the cooling heat exchanger 7 and the heating heat exchanger 2 are connected to the water inlet of the mixing pipe 12 through pipes.

[0077] When the sterilizer 1 is in the heating stage: the circulating water in the cabinet is pumped out along the direction of the arrow through the first water pump 6 and the second water pump 20 and enters the cooling heat exchanger 7 and the heating heat exchanger 2 along the circulating water pipe 19 in the cabinet respectively. The steam valve at the medium end of the heating heat exchanger 2 is opened, and the circulating water in the cabinet is heated by steam; the cooling water valve at the medium end of the cooling heat exchanger 7 is in a closed state. The cooling heat exchanger 7 is used as a bypass of the heating heat exchanger 2 in the heating stage to balance the water temperature, thereby avoiding the rapid heating of the circulating water in the cabinet, causing the pressure in the sterilization chamber 15 to rise rapidly, which puts too much pressure on the medicine bottle 17, resulting in uneven internal and external pressure of the medicine bottle 17 and deformation.

[0078] The circulating water in the cabinet that flows through the cooling heat exchanger 7 and the heating heat exchanger 2 is mixed in the mixing pipe 12 to make the water temperature relatively uniform. The mixed circulating water then flows into the balancing pipe 4 in the direction of the arrow and then into the constant pressure tank 3. The diameter of the balancing pipe 4 is from large to small to ensure that the water flow and pressure flowing into the constant pressure tank 3 are relatively uniform; a temperature controller 10 is installed on the constant pressure tank 3. The temperature controller 10 detects the temperature difference of the circulating water in multiple constant pressure tanks 3 and opens the temperature balancing device 11 set in the middle section of the balancing pipe 4 to add steam to fine-tune the temperature, so that the temperature of the circulating water in multiple constant pressure tanks 3 is similar; the circulating water with similar temperature and pressure passes through the constant pressure tank 3 into the constant pressure pipe 5 outside the cabinet for the second time, and then flows into the constant pressure pipe 18 inside the cabinet for the third time, and then flows into the water distribution tray 8 through the diversion pipe 9. The slight flow difference of multiple water distribution trays 8 is achieved by the flow regulating disc 13 set at the outlet end of the water distribution pipe.

[0079] After the circulating water flowing into the water distribution tray 8 is blocked by the retaining ring 14, it flows into the water storage chamber of the water distribution tray 8 to form an equal water level surface, the purpose of which is to ensure that each first leakage hole 21 of the water distribution tray 8 is evenly distributed and the amount of water flowing out is consistent; the function of the retaining ring 14 is to prevent the influence of the circulating water on the equal water level surface of the water distribution tray 8; the heated circulating water showers the medicine bottles 17 stored in the sterilization box 22 through the first leakage holes 21 evenly distributed on the water distribution tray 8, ensuring that each medicine bottle 17 is showered with circulating water with consistent temperature and flow at the same time; the circulating water flowing through the surface of the first layer of medicine bottles 17 then passes through the second leakage holes 23 at the upper end of the sterilization box 22 to form an equal liquid level surface in the hollow interlayer 25, and then showers the medicine bottles 17 of the next layer through the third leakage holes 24 on the lower layer of the sterilization box 22.

[0080] The principle of the sterilization and heat preservation stage is the same as that of the heating stage;

[0081] During the sterilization and cooling stage, the cooling water valve at the medium end of the heating heat exchanger 2 is opened, and the circulating water in the cabinet is cooled by the cooling water; the steam valve at the medium end of the heating heat exchanger is in a closed state, and the heating heat exchanger 2 is used as a bypass of the refrigeration heat exchanger 7 during the cooling stage to balance the water temperature, thereby preventing the circulating water in the cabinet from cooling rapidly and causing the pressure inside and outside the medicine bottle 17 to be uneven and deformed; at the same time, the temperature controller 10 detects the temperature difference of the circulating water in multiple constant pressure tanks 3 and fine-tunes the temperature by adding cooling water through the temperature balancing device 11 set in the middle section of the balancing pipe 4, so that the temperature of the circulating water in multiple constant pressure tanks 3 is similar. When the temperature is lower than 100°C, the temperature balancing device 11 stops working, and the rest of the work process is the same as the heating stage.

[0082] During the measurement phase, the measuring platform 36 is fixed with water collection and temperature measuring devices 27 whose number and position are consistent with the medicine bottles 17. The measuring platform 36 is level with the measuring water platform 38, and the measuring water platform 38 is level with the sterilization box 22 in the sterilization cabinet.

[0083] The control box 39 controls the servo motor 31 to drive the driving wheel of the servo motor 31, which in turn drives the measuring platform 36 via the timing belt 33. The measuring platform 36 slides on the movable balance guide rod 37 via the internal linear bearing. When the measuring platform 36 reaches the position sensor 35, the control box 39 sends a command to the servo motor 31, causing the measuring platform 36 to move to the physical position of the first row of medicine bottles 17.

[0084] The circulating water in the sterilizer flows out of the holes in the water distribution tray 8 in the water distribution system. When it flows through the water collection and thermometer 27, it is collected by the open funnel 40 of the water collection and thermometer 27 and then converges at the liquid collection pipe 41 inside the water collection and thermometer 27. Because the bottom diameter of the open funnel is greater than the bottom diameter of the liquid collection pipe 41, which is greater than the bottom diameter of the reducing pipe 43, the circulating water converges at the collecting pipe 41. The Class A temperature probe 42 placed at this position timely collects the temperature of the circulating water in the cabinet, and the temperature data is transmitted to the control box 39 via the data line 28. The circulating water in the cabinet then flows through the reducing pipe 43 inside the water collection and thermometer 27 again, and then flows through the water flow conduit 29 to the ultrasonic flowmeter 30. The flow rate data of the circulating water in the cabinet is transmitted to the control box 39 via the data line of the ultrasonic flowmeter 30. Since the bottom diameter of the liquid collecting pipe 41 is greater than the bottom diameter of the reducing pipe 43 , the air in the reducing pipe 43 and the water flow conduit 29 can be exhausted, thereby ensuring the accuracy of the measurement.

[0085] It should be noted that a certain amount of equilibration time is required when measuring data at the first row of medicine bottles 17 to avoid measurement errors caused by the temperature of the water collection thermometer 27 itself affecting the circulating water in the cabinet. Simultaneously, the control box 39 begins timing after the measurement platform 36 reaches the measurement position, calculating the time required for the circulating water in the cabinet to flow from the water collection thermometer 27 to the ultrasonic flowmeter 30. After collecting data from the Class A temperature probe 42 and the ultrasonic flowmeter 30, the control box 39 collects data at a rate of once per second until the data before and after each water collection thermometer 27 is essentially stable. It then controls the measurement platform 36 to move to the next row of medicine bottles 17 until data collection for the last row of medicine bottles 17 is complete.

[0086] After data collection is complete, the control box 39 outputs the temperature and water volume data for each row of each code water collection and temperature sensor 27, completing the water flow and temperature testing of the water bath sterilizer. Based on the data discrepancies, technicians identify areas that need adjustment and repeat the test until the flow and temperature at each point are essentially consistent.

[0087] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A water temperature and flow detection device for water bath sterilization of large infusion products, characterized in that: include: A sterilizer, wherein a sterilization cavity is provided in the sterilizer; A sterilization rack, the sterilization rack being slidably disposed in the sterilization cavity; A water distribution system is provided above the sterilization chamber and is used to spray and sterilize the products on the sterilization rack; A circulating water constant pressure system, which is arranged above the sterilizer and connected to the water distribution system; A temperature uniformity device, which is arranged on the circulating water constant pressure system; A water distribution temperature and flow detection system is installed in the sterilization rack and located below the water distribution system, and is used to detect the flow and temperature of water in the sterilization chamber; The water distribution temperature and flow detection system includes: A measuring water platform, which is installed on the sterilization rack; A measuring platform, wherein the measuring platform is slidably connected to the measuring horizontal platform; Water collection and temperature measuring devices, multiple of which are arranged on the measuring platform and located below the water distribution system; The water collection and temperature measuring device comprises: A pillar, wherein a hollow mounting cavity is provided in the pillar; an open funnel, the open funnel being arranged in the mounting cavity; a liquid collecting pipe, the liquid collecting pipe being arranged in the installation cavity, and the top of the liquid collecting pipe being sealedly connected to the lower part of the open funnel; A reducing pipe is arranged in the installation cavity, and the top of the reducing pipe is sealedly connected to the lower part of the collecting pipe; A water flow conduit, the water flow conduit being sealedly connected to the lower portion of the variable diameter pipe; an ultrasonic flow meter connected to the water flow conduit; a temperature probe, one end of which is disposed in the collecting pipe and the other end of which is disposed outside the support; A control box, the control box being communicatively connected to the temperature probe and the ultrasonic flow meter respectively; Among them, the bottom diameter of the open funnel is greater than the bottom diameter of the collecting pipe and greater than the bottom diameter of the reducing pipe; The measuring platform is slidably connected to the measuring horizontal platform through a control component, and the control component includes a servo motor, a synchronous belt, a mobile balance guide rod, and a synchronous belt cluster wheel. One end of the synchronous belt is sleeved on the output end of the servo motor, and the other end of the synchronous belt is sleeved on the synchronous belt cluster wheel installed on the measuring horizontal platform. The mobile balance guide rod is provided on the measuring horizontal platform, and the measuring platform is slidably sleeved on the mobile balance guide rod; the synchronous belt is fixedly connected to the measuring platform; The water bath sterilization temperature and pressure uniform water distribution system further comprises: a heating heat exchange device and a cooling heat exchange device respectively connected to the temperature uniform device; The water distribution system includes: A constant pressure pipe in the cabinet, which is connected to the water outlet of the circulating water constant pressure system; A plurality of shunt pipes are connected to the constant pressure pipe in the cabinet at equal intervals; Water distribution tray: multiple water distribution trays are arranged on the top of the sterilization chamber, and each water distribution tray is provided with a water storage cavity, and a plurality of first water leakage holes are provided at the bottom of the water storage cavity. Each water distribution tray corresponds to a diversion pipe; A retaining ring, the retaining ring is arranged at the bottom of the water storage chamber, and the diverter pipe is arranged in the retaining ring; The shunt pipe is U-shaped, the middle part of the shunt pipe is connected to the constant pressure pipe in the cabinet, each water distribution tray is provided with two retaining rings, the two ends of the U-shaped shunt pipe are respectively arranged in the retaining rings, and the two ends of the shunt pipe are respectively provided with flow regulating discs; The circulating water constant pressure system comprises: a balancing pipe, the inlet of which is connected to the water outlet of the temperature uniforming device; A constant pressure tank, wherein the water inlet of the constant pressure tank is connected to the outlet of the balance pipe; The constant pressure pipe outside the cabinet, the water outlet of the constant pressure tank is connected to the constant pressure pipe outside the cabinet, and the constant pressure pipe outside the cabinet is connected to the constant pressure pipe inside the cabinet through a connecting pipe, and the connecting pipe is sealed and fixed on the side wall of the sterilizer.

2. The water temperature and flow rate detection device for water bath sterilization of large infusion products according to claim 1 is characterized in that: The diameter of the open funnel is the same as the maximum cross-section of the vial.

3. The water temperature and flow rate detection device for water bath sterilization of large infusion products according to claim 1 is characterized in that: The heating and heat exchange device includes a heating heat exchanger and a first water pump. The water inlet of the first water pump is connected to the bottom of the sterilizer, the water outlet of the first water pump is connected to the water inlet of the heating heat exchanger, and the water outlet of the heating heat exchanger is connected to the water inlet of the mixing pipe.

4. The water temperature and flow rate detection device for water bath sterilization of large infusion products according to claim 1 is characterized in that: The sterilization rack includes: a plurality of stacked sterilization boxes, each of which is provided with a placement cavity, a bottom of the sterilization box having a hollow interlayer, a top wall of the hollow interlayer having a plurality of penetrating second water leakage holes, a bottom wall of the hollow interlayer having a plurality of penetrating third water leakage holes, and a diameter of the second water leakage holes being larger than a diameter of the third water leakage holes.

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