A production device for extracting heparin sodium using pig small intestinal mucosa

Abstract

The invention discloses a production device for extracting sodium heparin by utilizing pig small intestinal mucosa, comprising a feeding roller, a sleeve rod and a base, wherein the sleeve rod comprises an upper sleeve rod and a lower sleeve rod connected to the lower part of the upper sleeve rod, a deep hole 1 cooperating with the upper sleeve rod is provided on the upper part of the base, a deep hole 2 cooperating with the lower sleeve rod is provided at the bottom of the deep hole 1, the deep hole 2 passes through the lower side surface of the base, the upper sleeve rod and the lower sleeve rod are respectively located in the deep hole 1 and the deep hole 2, and an annular scraper is arranged on the outer wall of the upper sleeve rod. The invention can scrape off the mucosa in a long section of the small intestine, and at the same time does not affect the subsequent production of the small intestine as casing during the processing.

Description

Technical Field

[0001] The invention belongs to the technical field of sodium heparin extraction devices, and in particular relates to a production device for extracting sodium heparin by utilizing pig small intestinal mucosa. Background Art

[0002] Heparin sodium can interfere with many links of the blood coagulation process and has an anticoagulant effect both in vivo and in vitro. Its mechanism of action is relatively complex. It mainly binds to antithrombin III and enhances the latter's inhibitory effect on activated II, IX, X, XI and XII coagulation factors. Its consequences involve preventing platelet aggregation and destruction, hindering the formation of coagulation activating enzymes, preventing prothrombin from turning into thrombin, inhibiting thrombin, and thus hindering fibrinogen from turning into fibrin, thereby exerting an anticoagulant effect.

[0003] At present, sodium heparin is mainly extracted from the small intestinal mucosa of pigs and sheep and cattle lungs. Studies have shown that the content of sodium heparin is the highest in the small intestinal mucosa of pigs. Crude sodium heparin is a traditional export product of my country and occupies an important position in the world. Extracting sodium heparin requires multiple steps, and the small intestinal mucosa is usually obtained by manually scraping the outer wall of the small intestine. The inconvenience of scraping the small intestinal mucosa is a technical difficulty in this field. The Chinese invention with the existing publication number CN107629147A proposes a sodium heparin extraction device, including a ring knife seat, a ring scraper, an intestinal guide tube, and a guide tube. The intestinal head, pressure tank and end cover are provided on the ring knife holder, an inflatable ring scraper is installed on one end of the ring knife holder, and an intestinal guide tube is installed on the other end. The intestinal guide tube is equipped with a pressure tank connected to the inner cavity of the ring scraper; the intestinal guide head is distributed with a number of water spray channels connected to the water supply pipe, but the small intestine has good contractility, and this method is not thorough in scraping the mucosa in the small intestine. In addition to making sodium heparin, the small intestine is also a natural sausage casing. If the diameter of the ring scraper is increased to improve the scraping effect, it is very likely to cause the contractility of the small intestine to fail, affecting the later production of the casing. Summary of the invention

[0004] In view of the above problems, the present invention proposes a production device for extracting sodium heparin using pig small intestinal mucosa, which can scrape the mucosa in the small intestine without affecting the subsequent casing processing.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is as follows: it includes a sleeve rod and a base, the sleeve rod includes an upper sleeve rod and a lower sleeve rod connected to the lower part of the upper sleeve rod, the upper part of the base is provided with a deep hole 1 that cooperates with the upper sleeve rod, the bottom of the deep hole 1 is provided with a deep hole 2 that cooperates with the lower sleeve rod, the deep hole 2 runs through the lower side surface of the base, the upper sleeve rod and the lower sleeve rod are respectively located in the deep hole 1 and the deep hole 2, and the outer wall of the upper sleeve rod is provided with an annular scraper.

[0006] Furthermore, the upper and lower parts of the upper sleeve rod are hemispherical, the bottom surface of the deep hole 1 is provided with an arc surface matching with the lower part of the upper sleeve rod, and the opening of the upper part of the deep hole 1 is provided with an arc chamfer to prevent the casing from being damaged.

[0007] Furthermore, the length of the lower sleeve rod is greater than the length of the second deep hole, and a connecting plate is provided below the base, on which two rollers are provided on both sides of the lower sleeve rod, and two mutually meshing gears are provided on the rear side of the connecting plate, and the rollers on both sides of the lower sleeve rod are respectively connected to the gears through bearings, and the gears are connected to a reduction motor to automatically pull the casing downward.

[0008] Furthermore, the roller includes an axle body and a support block. The axle body is sleeved on the bearing. The outer wall of the axle body is provided with multiple circular holes. Springs are provided in the circular holes. The support block is movably connected in the circular holes and abuts against the springs. A track is sleeved on the side of the support block away from the spring.

[0009] Furthermore, the lower part of the connecting plate is connected to a bottom plate, and a collecting device is arranged on the bottom plate.

[0010] Furthermore, a slide groove is provided on the upper side of the bottom plate, and the collecting device includes a baffle slidably connected to the slide groove and a round tube fixed on the baffle. A notch is provided on the upper part of the round tube and is located at the lower part of the lower sleeve rod to achieve automatic shrinkage of the small intestine after scraping the inner mucosa.

[0011] Furthermore, an annular groove is provided on the inner wall of the deep hole 1, and a fitting device is arranged in the annular groove around the annular scraper. The fitting device includes a fitting wall, a fracture is vertically arranged on the fitting wall, threaded interfaces are arranged on both sides of the fitting wall, and adjustment bolts connected to the threaded interfaces are passed through both sides of the base.

[0012] Furthermore, a sealing ring is provided on the outer wall of the lower sleeve rod to prevent the scraped small intestinal mucosa from leaking downwards.

[0013] Furthermore, there are two annular scrapers, and the outer diameter of the annular scraper located at the lower part is slightly larger than that of the annular scraper located at the upper part. Through two-stage scraping, the mucosa in the small intestine can be scraped more thoroughly, and it is not easy to cause small intestine rupture due to the blade scraping too much small intestinal mucosa.

[0014] Compared with the prior art, the present invention has the following beneficial effects: the present invention can scrape off the mucosa of a long section of the small intestine and can automatically shrink the small intestine, which is very convenient, and at the same time does not affect the subsequent production of the small intestine as a casing during the processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention,

[0016] Figure 2 It is a schematic diagram of the cross-sectional structure of the present invention,

[0017] Figure 3 Schematic diagram of the gear connection structure of the present invention.

[0018] Figure 4 is a schematic diagram of the three-dimensional structure of the bonding device.

[0019] Figure 5 for Figure 2 Enlarged view of part A in the middle.

[0020] Figure 6 It is a schematic diagram of the cross-sectional structure of the roller.

[0021] In the figure: 1-base, 2-upper sleeve rod, 3-lower sleeve rod, 4-deep hole one, 5-deep hole two, 6-annular scraper, 7-connecting plate, 8-roller, 9-gear, 10-bearing, 11-reduction motor, 12-fitting wall, 13-fracture, 14-threaded interface, 15-adjusting bolt, 16-sealing ring, 17-bottom plate, 18-slide groove, 19-baffle, 20-round tube, 21-notch, 22-circular chamfer, 23-arc surface, 24-base cover, 25-axis body, 26-support block, 27-spring, 28-track. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 As shown, it includes a sleeve rod and a base 1, the sleeve rod includes an upper sleeve rod 2 and a lower sleeve rod 3 integrally connected to the lower part of the upper sleeve rod 2, a deep hole 1 4 cooperating with the upper sleeve rod 2 is opened on the upper part of the base 1, a deep hole 2 5 cooperating with the lower sleeve rod 3 is opened at the bottom of the deep hole 1 4, the deep hole 2 5 passes through the lower side of the base 1, the upper sleeve rod 2 and the lower sleeve rod 3 are respectively located in the deep hole 1 4 and the deep hole 2 5, the outer wall of the upper sleeve rod 2 is provided with an annular scraper 6, the annular scraper 6 is a triangular cross-section, one side of which is in contact with the outer wall of the upper sleeve rod 2 and the angle corresponding to this side is provided with a circular chamfer 22;

[0024] In the present embodiment; the upper and lower portions of the upper sleeve rod 2 are hemispherical, and the bottom surface of the deep hole 4 is provided with an arcuate surface 23 that cooperates with the lower portion of the upper sleeve rod 2;

[0025] In this embodiment, the length of the lower sleeve rod 3 is greater than the length of the deep hole 2 5, and a connecting plate 7 is welded and fixed below the base 1. Two rollers 8 located on both sides of the lower sleeve rod 3 are provided on the connecting plate 7. Two mutually meshing gears 9 are provided on the rear side of the connecting plate 7. The rollers 8 located on both sides of the lower sleeve rod 3 are connected to the gears 9 respectively through the bearings 10 provided therethrough. The bearings 10 are connected to the rollers 8 and the gears 9 through flat keys, and the gears 9 are fixedly connected to the driving shaft of the reduction motor 11.

[0026] In this embodiment, the roller 8 includes a shaft body 25 and a support block 26. The shaft body 25 is key-connected with the bearing 10. Six circular holes are opened on the outer wall of the shaft body 25. Springs 27 are arranged in the circular holes. The support block 26 includes a cylinder inserted into the circular holes and abutting against the springs. A support surface is welded at one end of the cylinder away from the spring. The support surface is in an arc shape. A track 28 is sleeved on the support surface. The track 28 is made of silicone.

[0027] In this embodiment, the lower part of the connecting plate 7 is fixedly connected to a bottom plate 17, a collecting device is arranged on the bottom plate 17, a chute 18 is provided on the upper side of the bottom plate 17, the collecting device comprises a baffle 19 slidably connected to the chute 18 and a round tube 20 vertically fixed on the baffle 19, the round tube 20 vertically corresponds to the lower sleeve rod 3, and a notch 21 located at the lower part of the lower sleeve rod 3 is provided on the upper part of the round tube 20;

[0028] In this embodiment; an annular groove is provided on the inner wall of the deep hole 4, and a base cover 24 is obtained by horizontally cutting the upper part of the annular groove, and the base cover 24 is connected to the base 1 by four screws, and a fitting device located around the annular scraper 6 is provided in the annular groove, and the fitting device includes a fitting wall 12, and a fracture 13 is vertically provided on the fitting wall 12, and threaded interfaces 14 are provided on both sides of the fitting wall 12, and two threaded holes corresponding to the threaded interfaces 14 are provided on both sides of the base 1, and adjusting bolts 15 threadedly connected to the threaded interfaces 14 and the threaded holes are provided on both sides of the base 1;

[0029] In the present embodiment; the outer wall of the lower sleeve rod 3 is provided with a sealing groove, and a sealing ring 16 is provided in the sealing groove, and the sealing ring 16 is a rubber ring;

[0030] In this embodiment, there are two annular scrapers 6, and the outer diameter of the annular scraper 6 located at the lower part is slightly larger than the annular scraper 6 located at the upper part;

[0031] When the present invention is working, the sleeve rod is inserted into the small intestine along the upper part of the upper sleeve rod 2, and one end of the small intestine with the sleeve rod inserted is inserted into the deep hole 1 4 and the deep hole 2 5 provided on the base 1 along the lower part of the lower sleeve rod 3. At this time, the small intestine sleeved on the bottom of the lower sleeve rod 3 is in contact with the two rollers 8 provided on the connecting plate 7. The collecting device is clamped on the bottom plate 17 through the slide groove 18 fixed on the bottom plate 17. At this time, the notch 21 on the upper part of the round tube 20 is facing the bottom of the lower sleeve rod 3. The adjusting bolt 15 provided on the side of the base 1 is adjusted. The fitting wall 12 applies appropriate pressure to the outer wall of the small intestine, and the reduction motor 11 is started. The reduction motor 11 drives the mutually meshing gears 9 to rotate, and the gears 9 drive the roller 8 to rotate. The roller 8 rotates in the direction of the lower sleeve rod 3. The roller 8 rubs the outer wall of the small intestine, so that the small intestine shrinks downward on the circular tube 20. At this time, the outer wall of the small intestine is scraped off the inner mucosa of the small intestine by the annular scraper 6, and the sealing ring 16 ensures that the scraped inner mucosa does not leak downward, and the scraped inner mucosa can be collected through the other end of the small intestine.

[0032] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A production device for extracting heparin sodium using pig small intestinal mucosa, characterized in that: It comprises a sleeve rod and a base, wherein the sleeve rod comprises an upper sleeve rod and a lower sleeve rod connected to the lower part of the upper sleeve rod, a deep hole 1 cooperating with the upper sleeve rod is opened on the upper part of the base, a deep hole 2 cooperating with the lower sleeve rod is opened at the bottom of the deep hole 1, the deep hole 2 passes through the lower side surface of the base, the upper sleeve rod and the lower sleeve rod are respectively located in the deep hole 1 and the deep hole 2, and an annular scraper is arranged on the outer wall of the upper sleeve rod; The length of the lower sleeve rod is greater than the length of the second deep hole, a connecting plate is provided below the base, two rollers are provided on the connecting plate and are located on both sides of the lower sleeve rod, two mutually meshing gears are provided on the rear side of the connecting plate, the rollers on both sides of the lower sleeve rod are connected to the gears respectively through bearings, and the gears are connected to a reduction motor; The lower part of the connecting plate is connected to a bottom plate, and a collecting device is arranged on the bottom plate; A chute is provided on the upper side of the bottom plate, and the collecting device comprises a baffle slidably connected to the chute and a round tube fixed on the baffle, and a notch is provided on the upper part of the round tube and is located at the lower part of the lower sleeve rod; The outer wall of the lower sleeve rod is provided with a sealing ring.

2. The production device for extracting heparin sodium using pig small intestinal mucosa according to claim 1, characterized in that: The upper and lower parts of the upper sleeve rod are hemispherical, the bottom surface of the deep hole 1 is provided with an arc surface matching with the lower part of the upper sleeve rod, and the opening of the upper part of the deep hole 1 is provided with an arc chamfer.

3. The production device for extracting heparin sodium using pig small intestinal mucosa according to claim 1, characterized in that: The roller includes an axle body and a support block. The axle body is sleeved on a bearing. A plurality of circular holes are opened on the outer wall of the axle body. Springs are arranged in the circular holes. The support block is movably connected in the circular holes and abuts against the springs. A track is sleeved on the side of the support block away from the spring.

4. The production device for extracting heparin sodium using pig small intestinal mucosa according to claim 1, characterized in that: An annular groove is provided on the inner wall of the deep hole 1, and a fitting device is arranged in the annular groove around the annular scraper. The fitting device includes a fitting wall, a fracture is vertically arranged on the fitting wall, threaded interfaces are arranged on both sides of the fitting wall, and adjusting bolts connected to the threaded interfaces are passed through both sides of the base.

5. The production device for extracting heparin sodium by using pig small intestinal mucosa according to claim 1, characterized in that: There are two annular scrapers, and the outer diameter of the annular scraper located at the lower part is slightly larger than that of the annular scraper located at the upper part.

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