A kind of synthesis method of 1,2,4-trifluorobenzene

By using 2,4-dichlorofluorobenzene as raw material and carrying out bromination, fluorination and Grignard hydrolysis reactions under the catalysis of Lewis acid, we successfully solved the problem of expensive raw materials and high cost of preparing 1,2,4-trifluorobenzene in the existing technology. The low-cost and efficient preparation of 1,2,4-trifluorobenzene has been achieved to solve the problems of low yield and serious safety hazards, which is suitable for industrial production.

CN115850018BActive Publication Date: 2024-10-18FUXIN RUIGUANG FLUORINE CHEM
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Patent Information

Application Number
CN202211669613.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-25
Publication Date
2024-10-18
Estimated Expiration
2042-12-25

AI Technical Summary

Technical Problem

Existing preparation methods for 1,2,4-trifluorobenzene have problems such as expensive raw materials, low yield, high safety hazards, and difficult wastewater treatment, which limit its industrial production and application.

Method used

Using 2,4-dichlorofluorobenzene as raw material, it reacts with bromination reagent under the catalysis of Lewis acid to generate 2,4-dichloro-5-fluorobromobenzene. After fluorination reaction and magnesium reaction, it generates Grignard reagent and then hydrolyzes. 1,2,4-trifluorobenzene is obtained. This method simplifies process steps, reduces equipment requirements, reduces waste generation, and improves safety and efficiency.

Benefits of technology

The low-cost, high-yield preparation of 1,2,4-trifluorobenzene is achieved, which reduces production costs, simplifies the process, improves safety and environmental protection, and is suitable for industrial production.

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Abstract

The invention provides a method for synthesizing 1,2,4-trifluorobenzene, and belongs to the field of fine chemicals. 2,4-dichlorofluorobenzene is used as a raw material, and reacts with a brominating agent under Lewis acid catalysis to generate 2,4-dichloro-5-fluorobromobenzene, which is synthesized by fluorination reaction to synthesize 2,4,5-trifluorobromobenzene and 2,4,5-trifluorochlorobenzene, and reacts with magnesium to generate a Grignard reagent, and then hydrolyzes to obtain 1,2,4-trifluorobenzene. The synthetic method uses cheap industrial chemicals as raw materials and reaction reagents, has the advantages of simple process, less three wastes, energy saving and high efficiency, and is a green and environmentally friendly synthetic method.
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