Double-layer medical membrane and its preparation method

Abstract

The present invention discloses a double-layer medical membrane and a method for making the same. The double-layer medical membrane includes a hydrophilic material layer and a hydrophobic material layer disposed on the hydrophilic material layer. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers and the hydrophilic particles includes a hydrophilic polymer. The method for making the double-layer medical membrane includes the following steps: using an electrospinning liquid to form a hydrophilic material layer by electrostatic spinning or using a hydrophilic solution to form a hydrophilic material layer; and obtaining a double-layer medical membrane including a hydrophilic material layer. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers or the hydrophilic particles includes a hydrophilic polymer. The double-layer medical membrane of the present invention has an anti-adhesion effect.

Description

Technical Field

[0001] The invention relates to a double-layer medical film and a preparation method thereof, in particular to a double-layer medical film with anti-adhesion effect and a preparation method thereof. Background Art

[0002] After surgery, the patient will have various wounds in the body. During the healing process, the wound may ooze body fluids or blood. Once the wound comes into contact with other organs, it may cause adhesion. In order to avoid adhesion, the doctor will cover the wound with an anti-adhesion film after surgery to reduce the chance of adhesion.

[0003] The existing anti-adhesive films are all single-layer structures, and the components forming the anti-adhesive films are usually polylactic acid or carboxymethylcellulose. However, no matter whether the anti-adhesive films are made of polylactic acid or carboxymethylcellulose, they still have some defects and are not conducive to use.

[0004] Polylactic acid itself is a hydrophobic substance, so the anti-adhesive film made of polylactic acid has the problem of not being easy to adhere to the wound. Doctors still need to suture to fix the anti-adhesive film to the wound.

[0005] Although carboxymethyl cellulose anti-adhesive films are easier to adhere to wounds, carboxymethyl cellulose will swell after absorbing water and easily adhere to gloves or instruments. Therefore, when using carboxymethyl cellulose anti-adhesive films, Tyvek paper is usually used in combination. Tyvek paper is placed on the anti-stick film to facilitate doctors to perform sutures or other treatment steps.

[0006] Based on the above content, it can be seen that no matter whether it is anti-adhesive films made of polylactic acid or carboxymethyl cellulose, there are some problems in their use and they still need to be improved. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a double-layer medical membrane and a preparation method thereof in view of the deficiencies of the prior art.

[0008] In order to solve the above technical problems, one of the technical solutions adopted by the present invention is to provide a double-layer medical membrane. The double-layer medical membrane includes a hydrophilic material layer and a hydrophobic material layer. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers and the hydrophilic particles includes a hydrophilic polymer. The hydrophobic material layer is arranged on the hydrophilic material layer.

[0009] Preferably, the hydrophilic polymer is selected from the group consisting of hyaluronic acid, carboxymethyl cellulose, collagen, gelatin, alginate and chitosan.

[0010] Preferably, the molecular weight of the hydrophilic polymer is 2000 g / mol to 2000000 g / mol.

[0011] Preferably, the material of the hydrophilic fiber further includes an excipient, and the weight ratio of the hydrophilic polymer in the hydrophilic fiber to the excipient is 1:30 to 5:1.

[0012] Preferably, the hydrophobic material layer is formed by a hydrophobic fiber, and the diameter of the hydrophobic fiber is 200 nanometers to 3000 nanometers.

[0013] Preferably, the hydrophobic material layer is formed by electrospinning.

[0014] Preferably, the tensile strength of the double-layer medical film is 1.1 MPa to 5.2 MPa.

[0015] In order to solve the above technical problems, another technical solution adopted by the present invention is to provide a method for preparing a double-layer medical membrane. The method for preparing the double-layer medical membrane includes: using an electrospinning liquid to form a hydrophilic material layer by electrostatic spinning; preparing a double-layer medical membrane including a hydrophilic material layer. The hydrophilic material layer includes hydrophilic fibers, and the material of the hydrophilic fibers includes a hydrophilic polymer. The double-layer medical membrane also includes a hydrophobic material layer disposed on the hydrophilic material layer.

[0016] Preferably, the material of the hydrophilic fiber also includes an excipient, and the electrospinning solution includes: 5 to 75 weight percent alcohol, 25 to 95 weight percent water, 0.5 to 5 weight percent hydrophilic polymer and 2 to 15 weight percent excipient.

[0017] In order to solve the above technical problems, another technical solution adopted by the present invention is to provide a method for preparing a double-layer medical membrane. The method for preparing the double-layer medical membrane includes: using a hydrophilic solution to form a hydrophilic material layer to prepare a double-layer medical membrane including a hydrophilic material layer. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers and the hydrophilic particles includes a hydrophilic polymer. The double-layer medical membrane also includes a hydrophobic material layer disposed on the hydrophilic material layer.

[0018] One of the beneficial effects of the present invention is that the double-layer medical membrane and its preparation method provided by the present invention can solve the problem of the inconvenience of using the previous single-layer medical membrane through the technical solutions of "the hydrophilic material layer is formed by hydrophilic fibers, hydrophilic particles or their combination" and "the hydrophobic material layer is arranged on the hydrophilic material layer".

[0019] To further understand the features and technical contents of the present invention, please refer to the following detailed description and drawings of the present invention. However, the drawings provided are only for reference and description and are not intended to limit the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the use of the double-layer medical membrane of the present invention.

[0021] Figure 2 It is a cross-sectional schematic diagram of the double-layer medical membrane of the present invention.

[0022] Figure 3 for Figure 2 An enlarged schematic diagram of part III.

[0023] Figure 4 It is a schematic diagram of an electrospinning device for implementing the method for manufacturing a double-layer medical membrane of the present invention.

[0024] Figure 5 for Figure 2 An enlarged schematic diagram of part V.

[0025] Figure 6 The figure is a flow chart of a method for preparing a double-layer medical membrane according to one embodiment of the present invention.

[0026] Figure 7 The present invention is a flow chart of a method for preparing a double-layer medical membrane according to another embodiment of the present invention.

[0027] Figure 8 The present invention is a flowchart of a method for preparing a double-layer medical membrane according to another embodiment of the present invention. DETAILED DESCRIPTION

[0028] The following is an explanation of the embodiments of the "double-layer medical membrane and its preparation method" disclosed in the present invention through specific examples. Those skilled in the art can understand the advantages and effects of the present invention from the contents disclosed in this specification. The present invention can be implemented or applied through other different specific embodiments, and the details in this specification can also be modified and changed in various ways based on different viewpoints and applications without departing from the concept of the present invention. In addition, the drawings of the present invention are only simple schematic illustrations and are not depicted according to actual sizes. It is stated in advance. The following embodiments will further describe the relevant technical contents of the present invention in detail, but the disclosed contents are not intended to limit the scope of protection of the present invention. In addition, the term "or" used in this article may include any one or more combinations of the associated listed items depending on the actual situation.

[0029] Please refer to the combined Figure 1 and Figure 2 As shown, the double-layer medical membrane of the present invention comprises a hydrophilic material layer 1 and a hydrophobic material layer 2 which are stacked, and the hydrophilic material layer 1 and the hydrophobic material layer 2 are directly bonded. The hydrophilic material layer 1 can contact the wound A and has good adhesion. The hydrophobic material layer 2 can prevent the wound A from adhering to the surrounding organs, and the hydrophobic material layer 2 is not easy to adhere to the medical device T or medical consumables. Therefore, the double-layer medical membrane of the present invention has good convenience in use.

[0030] For ease of use, the total thickness of the double-layer medical membrane is 10 microns to 100 microns. Among them, the thickness of the hydrophilic material layer 1 is 5 microns to 50 microns, and the thickness of the hydrophobic material layer 2 is 5 microns to 90 microns. Preferably, the thickness of the hydrophobic material layer 2 is greater than the thickness of the hydrophilic material layer 1. More preferably, the thickness ratio of the hydrophobic material layer 2 to the hydrophilic material layer 1 is 2:1 to 6:1. In this way, the double-layer medical membrane of the present invention can have the effect of being easy to take.

[0031] The hydrophilic material layer 1 of the present invention can be formed by electrospinning or coating, but the present invention is not limited thereto. The hydrophilic material layer 1 includes hydrophilic fibers, hydrophilic particles or a combination thereof.

[0032] In some embodiments, the hydrophilic material layer 1 is formed by one or more hydrophilic fibers 11 (eg Figure 3 As shown). The material of the hydrophilic fiber 11 includes a hydrophilic polymer. The hydrophilic polymer is a polymer that is compatible with the human body. For example, the hydrophilic polymer can be hyaluronic acid, collagen, gelatin, alginate, chitosan or a combination thereof. In addition, the molecular weight of the hydrophilic polymer is 2000 g / mol to 2000000 g / mol. Preferably, the molecular weight of the hydrophilic polymer is 6000 g / mol to 200000 g / mol.

[0033] In some embodiments, the material of the hydrophilic fiber 11 may also be an excipient. The excipient can be attached to the hydrophilic polymer to enhance the structural properties of the hydrophilic material layer 1. For example, the excipient can be polyvinylalcohol (PVA), polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), carboxymethyl cellulose (carboxymethyl cellulose), stearic acid, starch or a combination thereof. In addition, the molecular weight of the excipient is 1000 g / mol to 2000000 g / mol. Preferably, the molecular weight of the excipient is 100000 g / mol to 600000 g / mol. For example, when the excipient is polyvinyl alcohol, the molecular weight of the polyvinyl alcohol is less than or equal to 2000000 g / mol; when the excipient is polyethylene glycol, the molecular weight of the polyethylene glycol is less than or equal to 1000000 g / mol.

[0034] In other embodiments, the hydrophilic material layer 1 is formed by a plurality of hydrophilic particles, preferably, the particle size of the hydrophilic particles ranges from 30 microns to 200 microns. The material of the hydrophilic particles includes a hydrophilic polymer. The hydrophilic polymer is a polymer that is compatible with the human body. For example, the hydrophilic polymer can be hyaluronic acid, collagen, gelatin, alginate, chitosan or a combination thereof. In addition, the molecular weight of the hydrophilic polymer is 2000 g / mol to 2000000 g / mol. Preferably, the molecular weight of the hydrophilic polymer is 6000 g / mol to 200000 g / mol.

[0035] The present invention forms a hydrophilic material layer including hydrophilic fibers and a hydrophilic material layer including hydrophilic particles by coating, and measures the contact angles of the two hydrophilic material layers, and the measurement results are shown in Table 1. According to the results in Table 1, it can be seen that the hydrophilic material layer including hydrophilic particles has better hydrophilicity.

[0036] Table 1

[0037] Hydrophilic material layer Water contact angle Hydrophilic material layer including hydrophilic fibers 66 to 78 degrees Hydrophilic material layer including hydrophilic particles 59 to 64 degrees

[0038] In some embodiments, the hydrophilic material layer 1 is formed by hydrophilic fibers and hydrophilic particles. The materials of the hydrophilic fibers and the hydrophilic particles are as described above and will not be described in detail herein.

[0039] When the hydrophilic material layer 1 is formed of hydrophilic fibers 11, the hydrophilic material layer 1 can be formed by electrospinning or coating. In an exemplary embodiment, the hydrophilic material layer 1 is formed by electrospinning using an electrospinning device 3.

[0040] See also Figure 4 As shown, the electrospinning device 3 mainly includes a spinneret 31, a high voltage power supply 32 and a collecting plate 33. The spinneret 31 includes a liquid storage tank 311 and a nozzle 312, the first nozzle 312 is in fluid communication with the bottom of the first liquid storage tank 311, and the positive and negative electrodes of the high voltage power supply 32 are electrically connected to the nozzle 312 and the collecting plate 33, respectively.

[0041] When in use, the electrospinning liquid L is first placed in the liquid storage tank 311, and then the high voltage power supply 32 generates an electric field of a predetermined strength between the spinneret 31 and the collecting plate 33. After the electrospinning liquid L is ejected from the nozzle 312, it solidifies to form hydrophilic fibers 11 and deposits on the collecting plate 33. By controlling the movement of the spinneret 31, the hydrophilic fibers 11 can be closely stacked, entangled or interwoven in a specific direction to form a hydrophilic material layer 1 with uniform thickness.

[0042] The main components of the electrospinning liquid L include a solid component and a solvent, and the solvent is used to disperse the solid component. In the electrospinning liquid L used to form the hydrophilic material layer, the solid component includes a hydrophilic polymer and an excipient, and the solvent is an aqueous solvent that is non-cytotoxic and meets the medical material standards, such as a mixture of water and alcohol, wherein the weight ratio of water to alcohol can be 1:9 to 9:1.

[0043] In a preferred embodiment, the electrospinning liquid L used to form the hydrophilic material layer 1 includes 5 to 75 weight percent alcohol, 25 to 95 weight percent water, 0.5 to 5 weight percent hydrophilic polymer, and 2 to 15 weight percent excipient. However, the present invention is not limited thereto.

[0044] In addition, the parameters that can be adjusted by the electrospinning device 3 include: the concentration of the electrospinning liquid L, the spinning temperature, the electric field strength, the collection distance (or the deposition distance), the collection time and other parameters. In this embodiment, the spinning temperature can be 5°C to 95°C, and preferably 10°C to 90°C, the voltage strength is 5 to 60 kilovolts (KV), and preferably 10 to 25 kilovolts, the ejection speed of the electrospinning liquid L is 0.1 to 10 cc / min, and there is a collection distance of 15 to 90 cm between the nozzle 31 and the collection plate 33. However, these details are only used to describe the feasible implementation scheme of electrospinning and are not used to limit the present invention.

[0045] The material of the hydrophilic fiber 11 includes the aforementioned hydrophilic polymer and excipient (ie, the solid component in the electrospinning solution). The weight ratio of the hydrophilic polymer to the excipient is 1:30 to 5:1, preferably, the weight ratio of the hydrophilic polymer to the excipient is 1:10 to 3:1.

[0046] See also Figure 5As shown, the hydrophobic material layer 2 of the present invention can also be formed by one or more hydrophobic fibers 21. However, the present invention is not limited to this. Microscopically, the hydrophobic material layer 2 is a porous structure. The diameter of the hydrophobic fibers 21 is 200 nanometers to 3000 nanometers, so that the hydrophobic material layer 2 has a suitable structural strength as a substrate. However, the structure of the hydrophobic material layer 2 is not limited to this, and the hydrophobic material layer 2 can also be a solid layer body, or a layer body of other structures.

[0047] The hydrophobic material layer 2 can be formed by electrospinning, coating or extrusion. In a preferred embodiment, the hydrophobic material layer 2 is formed by electrospinning, and the formation method is similar to the above, the difference is that the electrospinning liquid L used to form the hydrophobic material layer 2 is different from the electrospinning liquid L used to form the hydrophilic material layer 1.

[0048] The electrospinning liquid L for forming the hydrophobic material layer 2 includes a solid component and a solvent, and the solid component includes a hydrophobic polymer.

[0049] The material of the hydrophobic material layer 2 includes a hydrophobic polymer, which may be polylactic acid (PLA), polycaprolactone (PCL), poly(lactic-co-glycolic acid, PLGA), polyhydroxyalkanoates (PHA), polyglycolic acid (PGA) or a combination thereof.

[0050] In a preferred embodiment, the hydrophobic polymer is polylactic acid, and the hydrophobic polymer includes both D-type polylactic acid and L-type polylactic acid. It is worth noting that when the hydrophobic polymer is polylactic acid, the electrospinning liquid L must contain both D-type polylactic acid and L-type polylactic acid, otherwise the polylactic acid cannot form a uniform dispersion. In some embodiments, the weight ratio of D-type polylactic acid to L-type polylactic acid is 1:9 to 9:1. Preferably, the weight ratio of D-type polylactic acid to L-type polylactic acid is 5:5 to 8:2. More preferably, the content of D-type polylactic acid is higher than that of L-type polylactic acid.

[0051] The solvent is a non-cytotoxic organic solvent. For example, the solvent can be one of acetone, butanone, ethylene glycol, hexafluoroisopropanol (HFIP) and isopropanol and one of deacetylated chitosan (DAC), N,N-dimethylformamide (DMF), dimethylacetamide (DMAC), dimethyl sulfoxide (DMSO) and diethyl ether. In a preferred embodiment, the organic solvent is a mixture of acetone and dimethylacetamide, and the weight ratio of acetone to dimethylacetamide is 1:9 to 9:1.

[0052] In a preferred embodiment, the electrospinning solution L used to form the hydrophobic material layer 2 includes 99 weight percent of butanone and 0.5 to 15 weight percent of the hydrophobic polymer. However, the present invention is not limited thereto.

[0053] It should be noted that the formation of hydrophobic fibers by electrospinning does not affect the crystallinity of the hydrophobic polymer. Therefore, the hydrophobic material layer 2 formed by electrospinning in the present invention has better tensile strength than the hydrophobic material layer 2 formed by hot pressing.

[0054] In a preferred embodiment, the hydrophilic material layer 1 and the hydrophobic material layer 2 are both formed by electrospinning. Microscopically, there is a transition region between the hydrophilic material layer 1 and the hydrophobic material layer 2. In the transition region, the hydrophilic fibers 11 and the hydrophobic fibers 22 are interwoven in a thickness direction, so that there is sufficient bonding force between the hydrophilic material layer 1 and the hydrophobic material layer 2. Therefore, the double-layer medical membrane of the present invention can have good elasticity and extension properties.

[0055] The single-layer polylactic acid anti-adhesive film currently available on the market is made by extrusion, and the tensile strength measured according to the ASTM D882 test standard is 0.3MPa. The double-layer medical film of the present invention, which is formed by electrospinning with a hydrophilic material layer 1 and a hydrophobic material layer 2, has a tensile strength of 2.58MPa measured according to the ASTM D882 test standard.

[0056] The method for preparing the double-layer medical membrane of the present invention comprises the following steps: forming a hydrophilic material layer; preparing a double-layer medical membrane including the hydrophilic material layer. The hydrophilic material layer comprises hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers or hydrophilic particles comprises hydrophilic polymers. The double-layer medical membrane also comprises a hydrophobic material layer, and the hydrophobic material layer is disposed on the hydrophilic material layer.

[0057] It is worth noting that there is no specific order for forming the hydrophilic material layer 1 and the hydrophobic material layer 2. That is, the hydrophobic material layer 2 may be formed first, and then the hydrophilic material layer 1 may be formed on the hydrophobic material layer 2; or, the hydrophilic material layer 1 may be formed first, and then the hydrophobic material layer 2 may be formed on the hydrophilic material layer 1.

[0058] See also Figure 6As shown, the method for preparing a double-layer medical membrane in one embodiment of the present invention includes the following steps: first, prepare a first electrospinning liquid and a second electrospinning liquid, the first electrospinning liquid is used to form a hydrophilic material layer 1, and the second electrospinning liquid is used to form a hydrophobic material layer 2 (step S1). Use the first electrospinning liquid to spray it on the collection plate 33 in an electrostatic spinning manner (step S2a). Dry and solidify the first electrospinning liquid to form a hydrophilic material layer 1 (step S3a). Use the second electrospinning liquid to spray it on the hydrophilic material layer 1 in an electrostatic spinning manner (step S4a). Dry and solidify the second electrospinning liquid to form a hydrophobic material layer 2 on the hydrophilic material layer 1, and obtain a double-layer medical membrane (step S5a).

[0059] See also Figure 7 As shown, in another embodiment of the present invention for preparing a double-layer medical membrane, a first electrospinning liquid and a second electrospinning liquid are first prepared, the first electrospinning liquid is used to form a hydrophilic material layer 1, and the second electrospinning liquid is used to form a hydrophobic material layer 2 (step S1). The second electrospinning liquid is used to spray on the collecting plate 33 by electrostatic spinning (step S2b). The second electrospinning liquid is dried and solidified to form a hydrophobic material layer 2 (step S3b). The first electrospinning liquid is used to spray on the hydrophobic material layer 2 by electrostatic spinning (step S4b). The first electrospinning liquid is dried and solidified to form a hydrophilic material layer 1 on the hydrophobic material layer 2, and a double-layer medical membrane is obtained (step S5b).

[0060] The double-layer medical membrane prepared according to the above-mentioned method for preparing the double-layer medical membrane can have good elasticity and extension properties. In addition, there is a transition region between the hydrophilic material layer 1 and the hydrophobic material layer 2. In the transition region, the hydrophilic fibers 11 and the hydrophobic fibers 22 are interwoven with each other in the thickness direction, so that the hydrophilic material layer 1 and the hydrophobic material layer 2 have sufficient bonding force.

[0061] See also Figure 8 As shown, in another embodiment of the present invention for preparing a double-layer medical membrane, a hydrophilic solution is first prepared, and the hydrophilic solution is used to form a hydrophilic material layer 1 (step S1c). The hydrophilic material layer 1 includes hydrophilic fibers, hydrophilic particles or a combination thereof, and the material of the hydrophilic fibers and the hydrophilic particles includes a hydrophilic polymer. The hydrophilic material layer 1 is formed using a hydrophilic solution (step S2c), and the formation method of the hydrophilic material layer 1 can be but is not limited to coating. Then, a double-layer medical membrane including the hydrophilic material layer 1 is prepared (step S3c). In step S3c, the hydrophilic material layer 1 can be formed on the hydrophobic material layer 2, or the hydrophilic material layer 1 can be formed first, and then the hydrophobic material layer 2 is arranged on the hydrophilic material layer 1.

[0062] [Beneficial Effects of Embodiments]

[0063] One of the beneficial effects of the present invention is that the double-layer medical membrane and its preparation method provided by the present invention can solve the problem of the inconvenience of using the previous single-layer medical membrane through the technical solution of "the hydrophilic material layer 1 is formed by hydrophilic fibers 11, hydrophilic particles or their combination" and "the hydrophobic material layer 2 is arranged on the hydrophilic material layer 1".

[0064] Furthermore, by adopting the technical solution that "the hydrophilic material layer 1 is formed by electrospinning", the tensile strength of the double-layer medical membrane can be improved.

[0065] Furthermore, by means of the technical solution that "the hydrophilic material layer 1 includes hydrophilic particles", the hydrophilic property of the hydrophilic material layer 1 in the double-layer medical membrane can be improved.

[0066] Furthermore, through the technical solution of "the hydrophobic material layer 2 is formed by a hydrophobic fiber 21, and the diameter of the hydrophobic fiber 21 is 200 nanometers to 3000 nanometers", the structural strength and tensile strength of the double-layer medical membrane can be improved.

[0067] The contents disclosed above are only preferred feasible embodiments of the present invention, and are not intended to limit the protection scope of the claims of the present invention. Therefore, all equivalent technical changes made using the contents of the present invention description and drawings are included in the protection scope of the claims of the present invention.

Claims

1. A double-layer medical membrane, characterized in that: The double-layer medical membrane comprises: a hydrophilic material layer, the hydrophilic material layer comprising hydrophilic particles and hydrophilic fibers, the material of the hydrophilic fibers and the hydrophilic particles comprising a hydrophilic polymer; and a hydrophobic material layer disposed on the hydrophilic material layer, wherein the hydrophobic material layer is formed by a hydrophobic fiber, the diameter of the hydrophobic fiber is 200 nanometers to 3000 nanometers, and the thickness of the hydrophobic material layer is 5 micrometers to 90 micrometers; Wherein, the hydrophobic material layer comprises a hydrophobic polymer, and the thickness ratio of the hydrophobic material layer to the hydrophilic material layer is 2:1 to 6:1; The hydrophobic polymer includes both D-type polylactic acid and L-type polylactic acid, and the content of the D-type polylactic acid is higher than that of the L-type polylactic acid.

2. The double-layer medical membrane according to claim 1, characterized in that: The hydrophilic polymer is selected from the group consisting of hyaluronic acid, carboxymethyl cellulose, collagen, gelatin, alginate and chitosan.

3. The double-layer medical membrane according to claim 1, characterized in that: The molecular weight of the hydrophilic polymer is 2000 g / mol to 2000000 g / mol.

4. The double-layer medical membrane according to claim 1, characterized in that: The material of the hydrophilic fiber also includes an excipient, and the weight ratio of the hydrophilic polymer in the hydrophilic fiber to the excipient is 1:30 to 5:

1.

5. The double-layer medical membrane according to claim 1, characterized in that: The hydrophobic material layer is formed by electrostatic spinning.

6. The double-layer medical membrane according to claim 1, characterized in that: The tensile strength of the double-layer medical membrane is 1.1 MPa to 5.2 MPa.

7. A method for preparing a double-layer medical membrane, characterized in that: The preparation method comprises: Using an electrospinning liquid to form a hydrophilic material layer by electrostatic spinning, the hydrophilic material layer includes hydrophilic particles and hydrophilic fibers, the material of the hydrophilic particles and the hydrophilic fibers includes a hydrophilic polymer, and the particle size of the hydrophilic particles is 30 microns to 200 microns; and Using a hydrophobic fiber to provide a hydrophobic material layer on the hydrophilic material layer by electrospinning, the diameter of the hydrophobic fiber is 200 nanometers to 3000 nanometers, and the thickness of the hydrophobic material layer is 5 micrometers to 90 micrometers; Wherein, the thickness ratio of the hydrophobic material layer to the hydrophilic material layer is 2:1 to 6:1; The hydrophobic material layer includes a hydrophobic polymer, and the hydrophobic polymer includes both D-type polylactic acid and L-type polylactic acid, and the content of the D-type polylactic acid is higher than that of the L-type polylactic acid.

8. A method for preparing a double-layer medical membrane, characterized in that: The preparation method comprises: Using a hydrophilic solution to form a hydrophilic material layer by coating, the hydrophilic material layer includes hydrophilic particles and hydrophilic fibers, and the material of the hydrophilic fibers and the hydrophilic particles includes a hydrophilic polymer; and Using a hydrophobic fiber to provide a hydrophobic material layer on the hydrophilic material layer in a coating manner, wherein the diameter of the hydrophobic fiber is 200 nanometers to 3000 nanometers, and the thickness of the hydrophobic material layer is 5 micrometers to 90 micrometers; Wherein, the thickness ratio of the hydrophobic material layer to the hydrophilic material layer is 2:1 to 6:1; The hydrophobic material layer includes a hydrophobic polymer, and the hydrophobic polymer includes both D-type polylactic acid and L-type polylactic acid, and the content of the D-type polylactic acid is higher than that of the L-type polylactic acid.

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