A cutting device for tissue blocks during stem cell culture

Abstract

The present invention relates to a cutting device for tissue blocks during stem cell culture, which includes at least two groups of blade assemblies. Each blade assembly includes two blades hinged to each other. At least two groups of blade assemblies are hinged on the same pin shaft and can slide on the pin shaft. One blade of at least two groups of blades is slidably connected through a sliding shaft, and the other blade is slidably connected through another sliding shaft. The outermost two blades are respectively provided with screw connection parts, and threaded holes are provided on the screw connection parts. The thread spiral directions of the two threaded holes are opposite. Elastic members are installed on the pin shaft and the sliding shaft, and both ends are abutted against the two groups of blade assemblies. Two handle connecting pieces are respectively installed on the two sliding shafts. A first handle and a second handle are respectively fixed on the two handle connecting pieces. The two ends of a double-headed screw are respectively screwed into the two threaded holes. The above components are all made of 316 stainless steel. The present invention can quickly complete the adjustment of the spacing between multiple groups of blade assemblies, and the spacing is equal, which can meet the requirements of sampling different tissues.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a cutting device for tissue blocks during stem cell culture. Background Art

[0002] When taking stem cell samples from biological tissues, it is usually necessary to shear the biological tissues to obtain specific-sized tissue fragments that meet the operation requirements.

[0003] In the prior art, the patent application number CN201922499135.8, titled "A multi-scissor-head tissue scissor", discloses the following content: It includes five mutually parallel scissor heads and two scissor handles. The five scissor heads are all hinged through a rotating shaft. Each scissor head includes two paired scissor blades. The ends of the five pairs of scissor blades are respectively connected through a detachable connection mechanism. The end of the middle scissor blade is fixedly connected to the scissor handle.

[0004] However, through analysis, it is found that the above technical solution has the following deficiencies:

[0005] The spacing between the multi-scissor heads is fixedly set and cannot be adjusted. When sampling different tissues, the problem of being unable to adjust the spacing between the multi-scissor heads results in its inability to meet the sampling requirements of different tissues. Summary of the Invention

[0006] In view of this, the purpose of the present invention is to provide a cutting device for tissue blocks during stem cell culture to solve the above problems.

[0007] The technical solution of the present invention is as follows:

[0008] A cutting device for tissue blocks during stem cell culture, characterized in that it includes:

[0009] At least two groups of blade assemblies, at least two groups of the blade assemblies are arranged side by side at intervals and are slidably installed on the same pin shaft; each group of the blade assemblies includes two blades hinged through a pin shaft. Each blade includes a cutting part and a connecting part extending obliquely backward from the cutting part. A pin hole is provided at the connection between the cutting part and the connecting part. The blade is installed on the pin shaft through the pin hole and can rotate and slide on the pin shaft; a sliding connection hole is provided on the connecting part; the two outermost blades are respectively provided with a lead screw connection part, and a threaded hole is provided on the lead screw connection part. The thread spiral directions of the two threaded holes are opposite;

[0010] Sliding connection shafts, there are two sliding connection shafts in total, which are respectively installed in a plurality of coaxial sliding connection holes; the blades can slide on the sliding connection shafts;

[0011] Elastic members, the elastic members are sleeved on the pin shaft and the sliding connection shafts, and their two ends are respectively abutted against two groups of blade assemblies;

[0012] Handle connecting pieces, there are two handle connecting pieces in total, which are fixedly connected to the two sliding shafts respectively;

[0013] The first handle, which is fixedly connected to one of the handle connecting pieces;

[0014] The second handle, which is fixedly connected to the other handle connecting piece;

[0015] And a double-headed lead screw, the threads on both sides of the double-headed lead screw are respectively adapted to the threads of the two lead screw connecting parts; both ends of the double-headed lead screw are screwed to two threaded holes;

[0016] The blade, the pin shaft, the sliding shaft, the elastic member, the handle connecting piece, the first handle, the second handle and the double-headed lead screw are all made of 316 stainless steel.

[0017] As a further improvement of the present invention, the elastic member is a flat-end wave spring.

[0018] As a further improvement of the present invention, the surfaces of the first handle and the second handle are set as matte surfaces.

[0019] As a further improvement of the present invention, the cutting edge of the cutting part is set as a serrated structure.

[0020] As a further improvement of the present invention, scale marks are arranged circumferentially on the outer surface of one of the lead screw connecting parts.

[0021] As a further improvement of the present invention, one end of the double-headed lead screw connected to the lead screw connecting part provided with scale marks is fixedly connected with an adjusting knob, and a pointer is arranged on the adjusting knob.

[0022] As a further improvement of the present invention, the sliding hole is an elliptical structure, and a first connecting key is arranged thereon.

[0023] As a further improvement of the present invention, the cross-section of the sliding shaft is an elliptical structure the same as that of the sliding hole, and a key groove adapted to the first connecting key is arranged axially thereon; first bolt holes coaxial with it are arranged on both end faces of the sliding shaft; the sliding shaft is slidably connected in the sliding hole by means of the first connecting key and the key groove.

[0024] As a further improvement of the present invention, the handle connecting member includes a handle connecting portion and a shaft connecting portion; there are two shaft connecting portions, which are respectively fixedly connected to both ends of the handle connecting portion; an installation groove is provided on the shaft connecting portion, and the installation groove is an elliptical structure identical to the sliding hole, and a second connecting key adapted to the key groove is provided in the installation groove; a second bolt hole coaxial with the installation groove is provided on the shaft connecting portion; the sliding shaft is fixedly connected to the handle connecting member by inserting both ends thereof into the installation groove; the first handle and the second handle are respectively fixedly connected to the two handle connecting portions.

[0025] As a further improvement of the present invention, it further includes a screw, and the screw is screwed to the first bolt hole and the second bolt hole on the same side.

[0026] It can be seen from the above technical solutions that, compared with the prior art, the present invention has the following advantages:

[0027] 1. By setting the double-headed lead screw and the elastic member, the distance between multiple groups of blade assemblies can be quickly adjusted, and the distance between each adjacent two groups of blade assemblies is ensured to be equal, which can meet the working requirements of sampling different tissues;

[0028] 2. The whole scissors are made of 316 stainless steel and can be directly sterilized with strong acid or treated by high temperature and high pressure;

[0029] 3. The present invention can perform shearing and sampling on biological tissues at one time, effectively reducing the tissue processing time, improving the sampling efficiency, and ensuring the acquisition amount of subsequent stem cells;

[0030] 4. The design of the serrated structure at the blade edge can effectively prevent the tissue from sliding relative to the scissors during sampling, ensuring the sampling quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 is a perspective view of the present invention in the closed state;

[0032] Figure 2 is a perspective view of the present invention after being opened and adjusted;

[0033] Figure 3 is an exploded view of the present invention;

[0034] Figure 4 is a front view of the blade;

[0035] Figure 5 is Figure 1 an enlarged view of part A of

[0036] Figure 6 is Figure 3 an enlarged view of part B of

[0037] Figure 7 is Figure 3Enlarged view at C

[0038] Markings in the figure:

[0039] 1. Pin shaft 2. Blade 3. Cutting part 4. Connecting part

[0040] 5. Pin hole 6. Sliding hole 7. Lead screw connecting part 8. Threaded hole

[0041] 9. Sliding shaft 10. Elastic part 11. Handle connecting part 12. First handle

[0042] 13. Second handle 14. Double - headed lead screw 15. Blade edge 16. Serrated structure

[0043] 17. Scale mark 18. Adjusting knob 19. Pointer 20. First connecting key

[0044] 21. Keyway 22. First bolt hole 23. Handle connecting part 24. Shaft connecting part

[0045] 25. Installation groove 26. Second connecting key 27. Second bolt hole 28. Screw Detailed implementation mode

[0046] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and do not limit the present invention.

[0047] It should be understood that the orientation or positional relationship indicated by terms such as "upper end face, top end, left and right ends, left side, right side" is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present invention.

[0048] The present invention provides a cutting device for tissue blocks during stem cell culture, including a blade assembly, a sliding shaft 9, an elastic part 10, a handle connecting part 11, a first handle 12, a second handle 13, a double - headed lead screw 14 and a screw 28.

[0049] As Figure 4As shown in the figure, the blade 2 is composed of a cutting part 3 and a connecting part 4. The cutting part 3 is used for shearing biological tissues, and the connecting part 4 is used to connect the sliding shaft 9. On one side of the cutting part 3, there is a cutting edge 15, and the cutting edge 15 is set as a serrated structure 16. The design of the serrated structure 16 can effectively prevent the sliding of biological tissues at the cutting edge 15 during shearing sampling, thereby ensuring the sampling quality. The connecting part 4 and the cutting part 3 are integrally formed. The cutting part 3 extends backward at an angle of 25° with the horizontal to form the connecting part 4. At the connecting position between the cutting part 3 and the connecting part 4, there is a pin hole 5 for hinging and connecting the pin shaft 1.

[0050] As Figure 1 shown in the figure, in this embodiment, there are a total of 12 blades 2, and every two blades form a set of blade assemblies, with a total of 6 sets of blade assemblies. In each set, the two blades 2 are hinged in a way that the cutting edges 15 face each other. The axes of the pin holes 5 of each blade 2 in the 6 sets of blade assemblies coincide. The 6 sets of blades 2 are arranged parallel to each other at intervals, and the distance between each adjacent two sets of blade assemblies is equal. The two blades 2 in each set are hinged by inserting the pin shaft 1 into the pin hole 5. The 6 sets of blade assemblies are installed on the same pin shaft 1 and can slide on this pin shaft 1.

[0051] As Figure 7 shown in the figure, on the connecting part 4 of each blade 2, there is a sliding hole 6. The shape of the sliding hole 6 is a non-circular structure, which is set as an elliptical structure in this embodiment. Along the central direction of the sliding hole 6, there are two first connecting keys 20, and the two first connecting keys 20 are respectively located at both ends of the major axis of the elliptical structure.

[0052] As Figure 6 shown in the figure, the cross-section of the sliding shaft 9 is the same elliptical structure as the sliding hole 6. Along the axial direction of the sliding shaft 9, there are two key grooves 21 penetrating the front and rear end faces, which are respectively located at both ends of the major axis of the elliptical structure. The structure of the key grooves 21 is the same as the shape and size of the first connecting keys 20. As Figure 2 shown in the figure, each set of blade assemblies includes a blade 2 with the connecting part 4 upward and a blade 2 with the connecting part 4 downward. The 6 blades 2 with the connecting part 4 upward in the 6 sets of blade assemblies are connected by inserting the sliding shaft 9 into the sliding holes 6 in the same way, and the other 6 blades 2 with the connecting part 4 downward are connected by inserting the sliding shaft 9 into the sliding holes 6 in the same way. There are a total of two sliding shafts 9. The blades 2 can slide on the sliding shafts 9 they are connected to and cannot rotate. The design of the elliptical structure of the sliding hole 6 and the first connecting keys 20, and the design of the elliptical structure of the sliding shaft 9 and the key grooves 21 can effectively prevent relative rotation between the sliding shaft 9 and the blade 2 and ensure that the blade 2 can slide on the sliding shaft 9.

[0053] As Figure 3As shown, on the two outermost blades 2 at the front and back, there is respectively provided a lead screw connection part 7. The lead screw connection part 7 is of a plate - type structure, on which there is a threaded hole 8 for connecting the double - headed lead screw 14. The thread spiral directions of the threaded holes 8 of the two blades 2 are opposite. After installation, the axes of the two threaded holes 8 are in a coincident state.

[0054] As Figure 5 shown, the elastic member 10 is a flat - end wave spring, and its number is 15, with 5 in a group and a total of three groups. The three groups of flat - end wave springs are sleeved on the pin shaft 1 and the two sliding shafts 9. The two ends of each flat - end wave spring respectively abut against the end faces of two adjacent blades 2 in the two groups of blade assemblies, providing tension for the above - mentioned two blades 2. The advantage of selecting the flat - end wave spring is that it can provide a precisely controllable force value requirement. Under the same conditions, its spring stiffness output is greater than that of an ordinary spring, effectively saving axial space.

[0055] As Figure 3 shown, the threads on both sides of the double - headed lead screw 14 are respectively adapted to the threads of the two lead screw connection parts 7. The double - headed lead screw 14 is installed in the two lead screw connection parts 7, and its two ends are respectively screwed to the two threaded holes 8. The lead pitches of the threads on both sides of the double - headed lead screw 14 are both 1 mm, that is, when the double - headed lead screw 14 rotates one week, the moving distance of the blade 2 is 1 mm. By rotating the double - headed lead screw 14, the distance between the two outermost blades 2 can be adjusted. Through the elastic member 10, the distances between the six - group blade assemblies can be evenly divided, ensuring that the sizes of the tissue blocks obtained during shearing are the same. The distance adjustment range of the present invention is 2 - 10 mm. Through the design of the three - group springs, the tension received by each group of blade assemblies is distributed in a triangular shape, ensuring the force uniformity and further improving the structural stability.

[0056] As Figure 2 shown, there are two handle connection parts 11 in total, which are respectively fixedly connected to the two sliding shafts 9; As Figure 6 shown, each handle connection part 11 includes a handle connection part 23 and two shaft connection parts 24. The handle connection part 23 is of a columnar structure, and the shaft connection part 24 is of a plate - type structure; The two shaft connection parts 24 are respectively fixedly connected to the two end parts of the handle connection part 23; There is an installation groove 25 on the shaft connection part 24. The installation groove 25 is an elliptical structure the same as the sliding hole 6, and a second connection key 26 adapted to the key groove 21 is arranged in the installation groove 25; Each sliding shaft 9 is fixedly connected to the handle connection part 11 by inserting the two ends thereof into the installation groove 25.

[0057] The first connection key 20 can slide in the key groove 21, and the second connection key 26 is inserted into the key groove 21.

[0058] As Figure 2As shown, the surfaces of the first handle 12 and the second handle 13 are both frosted surfaces. The first handle 12 and the second handle 13 are respectively installed on two handle connection parts 23 by welding. The setting of the frosted surface can effectively enhance the gripping force of the operator and facilitate the operation of the operator.

[0059] In order to improve the connection stability between the handle connecting piece 11 and the sliding shaft 9, the following improvements are made:

[0060] Both ends of the sliding shaft 9 are provided with first bolts coaxial with it; the mounting groove 25 is provided with second bolt holes 27 penetrating through its inner and outer end faces. The second bolt holes 27 are coaxially arranged with the mounting groove 25, and the diameters of the first bolt holes 22 and the second bolt holes 27 are the same. After the installation of the handle connecting piece 11 and the sliding shaft 9 is completed, the second bolt holes 27 and the first bolt holes 22 are sequentially screwed by the screw 28, thereby improving the connection stability between the handle connecting piece 11 and the sliding shaft 9.

[0061] In order to facilitate the adjustment of the distance between the blade assemblies, the following improvements are made:

[0062] As Figure 7 shown, a scale mark 17 is axially arranged on the screw connection part 7 of the outermost front blade 2, and it is arranged with the axis of the threaded hole 8 as the center; the end of the double-headed screw 14 screwed with the threaded hole 8 is fixedly connected with an adjustment knob 18, and a pointer 19 is arranged on the adjustment knob 18. This design helps the operator to more clearly obtain the feed distance during adjustment and improves the accuracy of adjustment.

[0063] All components such as the blade 2, the pin shaft 1, the sliding shaft 9, the elastic member 10, the handle connecting piece 11, the first handle 12, the second handle 13, the double-headed screw 14, the screw 28, the adjustment knob 18 and the pointer 19 in the present invention are made of 316 stainless steel. Selecting 316 stainless steel material can ensure that the present invention can be directly sterilized with strong acid or treated with high temperature and high pressure, reused, ensure the safety of the sampling environment, improve the sampling quality, and save the use cost at the same time.

[0064] The above-described embodiments are only descriptions of the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the design spirit of the present invention, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention shall fall within the protection scope determined by the claims of the present invention.

Claims

1. A cutting device for tissue blocks during stem cell culture, characterized in that, Including: At least two groups of blade assemblies, the at least two groups of blade assemblies are arranged side by side at intervals and are slidably mounted on the same pin shaft (1); each group of blade assemblies includes two blades (2) hinged by the pin shaft (1), each blade (2) includes a cutting part (3) and a connecting part (4) formed by the cutting part (3) extending obliquely backward, a pin hole (5) is provided at the connection between the cutting part (3) and the connecting part (4), and the blade (2) is mounted on the pin shaft (1) through the pin hole (5) and can rotate and slide on the pin shaft (1); a sliding connection hole (6) is provided on the connecting part (4); the two outermost blades (2) are respectively provided with screw connection parts (7), a threaded hole (8) is provided on the screw connection part (7), and the thread spiral directions of the two threaded holes (8) are opposite; Sliding connection shafts (9), there are two sliding connection shafts (9) in total, which are respectively installed in a plurality of sliding connection holes (6) on the same axis; the blade (2) can slide on the sliding connection shaft (9); Elastic members (10), the elastic members (10) are sleeved on the pin shaft (1) and the sliding connection shafts (9), and both ends thereof are respectively abutted against two groups of blade assemblies; Handle connection members (11), there are two handle connection members (11) in total, which are respectively fixedly connected to the two sliding connection shafts (9); A first handle (12), the first handle (12) is fixedly connected to one handle connection member (11); A second handle (13), the second handle (13) is fixedly connected to the other handle connection member (11); And a double-headed screw (14), the threads on both sides of the double-headed screw (14) are respectively arranged to be adapted to the threads of the two screw connection parts (7); both ends of the double-headed screw (14) are respectively screwed into the two threaded holes (8); The blade (2), the pin shaft (1), the sliding connection shaft (9), the elastic member (10), the handle connection member (11), the first handle (12), the second handle (13) and the double-headed screw (14) are all made of stainless steel.

2. The cutting device according to claim 1, characterized in that: The elastic member (10) is a corrugated spring.

3. The cutting device according to claim 1, characterized in that: The surfaces of the first handle (12) and the second handle (13) are set as matte surfaces.

4. The cutting device according to claim 1, characterized in that: The cutting edge (15) of the cutting part (3) is set as a serrated structure (16).

5. The cutting device according to claim 1, characterized in that: A scale mark (17) is arranged on the outer surface of one screw connection part (7) along the circumferential direction.

6. The cutting device according to claim 5, characterized in that: One end of the double-headed screw (14) connected to the screw connection part (7) provided with the scale mark (17) is fixedly connected with an adjusting knob (18), and a pointer (19) is provided on the adjusting knob (18).

7. The cutting device according to claim 1, wherein: The sliding connection hole (6) is an elliptical structure, and a first connection key (20) is provided thereon.

8. The cutting device according to claim 7, characterized in that: The cross-section of the sliding connection shaft (9) is an elliptical structure the same as that of the sliding connection hole (6), and a key groove (21) adapted to the first connection key (20) is arranged thereon along the axial direction; first bolt holes (22) coaxial with it are arranged on both end faces of the sliding connection shaft (9); the sliding connection shaft (9) is slidably connected in the sliding connection hole (6) by means of the connection between the first connection key (20) and the key groove (21).

9. The cutting device according to claim 8, characterized in that: The handle connecting member (11) includes a handle connecting portion (23) and a shaft connecting portion (24); there are two shaft connecting portions (24), which are respectively fixedly connected to both ends of the handle connecting portion (23); an installation groove (25) is provided on the shaft connecting portion (24), and the installation groove (25) is an elliptical structure the same as the sliding hole (6), and a second connecting key (26) adapted to the key groove (21) is provided in the installation groove (25); a second bolt hole (27) coaxial with the installation groove (25) is provided on the shaft connecting portion (24); the sliding shaft (9) is fixedly connected to the handle connecting member (11) by inserting the installation grooves (25) at both ends thereof; the first handle (12) and the second handle (13) are respectively fixedly connected to the two handle connecting portions (23).

10. The cutting device according to claim 9, characterized in that: It further includes a screw (28), and the screw (28) is screwed into the first bolt hole (22) and the second bolt hole (27) on the same side.

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