Dual-modality optical scanning endoscopic probe integrated with hpv sampling function

Abstract

The application discloses a dual-mode optical scanning endoscope probe integrated with HPV sampling function, which comprises a probe body and a combined swab sampling structure, wherein the combined swab sampling structure comprises a swab sampling structure and a sample returning structure, the swab sampling structure comprises a fixing part, a sampling layer and a connecting unit, the sampling layer is a flocked swab layer fixed on the outer surface of the fixing part, and the connecting unit is used for fixing the fixing part on the probe body. The fixing part with the flocked swab layer is fixed on the end face of the outer sheath by the connecting unit, and the fixing is firm and reliable. In use, the optimal sampling position can be scanned and determined by the OCT probe, and since the flocked swab layer is integrated on the probe, the cell sample at the optimal sampling position can be directly obtained, that is, the high-precision sampling for HPV pathological detection is completed by directly using the OCT scanning technology, the discomfort caused by the sampling brush is avoided, the precision of the sampling position is ensured, the missed detection rate of the HPV pathological detection is reduced as much as possible, and the application has important popularization value.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of OCT detection, and in particular to a dual-mode optical scanning endoscope probe integrated with HPV sampling function. BACKGROUND

[0002] The screening of cervical cancer mainly adopts a "three-step" method: the first step is to perform a cervical cytology test (TCT) and / or HPV virus detection; the second step is to perform a colposcopy; and the third step is to perform a cervical pathological biopsy. Among them, the three steps are generally performed separately, the sample brush is used to obtain the sample in the first step, the sample brush has a conical structure, which brings a great discomfort to the user; the sample brush can only sample at a limited position, and the sampling accuracy is low, and there is a high missed detection rate; the colposcopy in the second step is to more accurately determine the lesion position, and lay a foundation for the biopsy sampling in the third step. Figure 1

[0003] OCT is a high-resolution non-invasive optical imaging technology, its basic principle is low-coherence interferometry, which uses low-coherence near-infrared light to irradiate biological tissues, and obtains two-dimensional cross-sectional images or three-dimensional reconstruction images with micrometer resolution of biological tissues by interference measurement of scattered light signals. In OCT, the image contrast is generated by the mismatch of the optical refractive index of the tissue structure, and no exogenous contrast agent is needed, and the imaging depth in the tissue is about 2-3mm. OCT is very suitable for surface applications, such as retinal imaging. With the development of OCT probe catheter technology in recent years, OCT has been more and more applied to the field of endoscopy, including cardiovascular, digestive tract, lung, throat and cervical endoscopy.

[0004] ​In recent years, OCT has rapidly developed in the field of cervical detection, and the applicant has also improved the OCT endoscopic probe for several generations. Specifically as follows: In order to apply OCT to cervical detection and improve the imaging effect, the applicant proposes an optical scanning probe (publication number: CN212261344U), which realizes the cell-level imaging of in vivo cervical tissue for the first time. However, since OCT scanning and colposcopy are independent, they are usually performed simultaneously during detection, and the sampling position is usually determined by the naked eye or colposcopy. However, due to the long distance between the observer and the cervical surface, and the obstruction of the speculum and other equipment, it is often difficult to accurately determine the OCT sampling position and observe the surface features of the sampling point. Therefore, the applicant proposes a dual-mode optical scanning endoscopic probe integrating OCT and electronic endoscopy (publication number: CN217338538U), that is, the LED lamp and endoscope are integrated on the probe tube of the endoscopic probe, which ensures accurate determination of the sampling position and sampling point of OCT, but the probe tube is more troublesome to disinfect and sterilize. Therefore, the applicant further proposes a dual-mode optical scanning endoscopic probe with an outer sheath (publication number: CN115299885A), which is a disposable sterile consumable and is easy to replace.

[0005] At present, the optical scanning probe for gynecological detection has been improved for several generations, and the operation is more convenient. It can also ensure cell-level imaging of the cervical surface, and has gradually replaced colposcopy in the second step of cervical cancer detection. However, although the OCT endoscopic scanning has many advantages, there is no related report on its use in the first step of cervical cancer detection, namely cervical cytology examination (TCT) and / or HPV virus detection. The main reasons are as follows: first, the size of the front end of the OCT probe is small and it integrates the OCT optical window, the endoscope window and the LED lamp window. It is one of the design difficulties to integrate the swab sampling structure on the probe and ensure the normal use of the probe. In addition, after sampling, the sample needs to be stored in a reagent tube with reagent. How to contactlessly remove the HPV sampling structure from the probe and place it in the reagent tube is another design difficulty of integrating HPV sampling on the OCT probe. SUMMARY

[0006] Therefore, the present application provides a dual-mode optical scanning endoscopic probe integrating HPV sampling function, which directly obtains the cervical tissue sample at the best sampling position by means of OCT scanning technology, and greatly reduces the missed detection rate in cervical cancer screening.

[0007] To achieve the above-mentioned purpose, the present application adopts the following technical solutions:

[0008] The dual-mode optical scanning endoscope probe integrating HPV sampling function comprises a probe body, and further comprises a combined swab sampling structure, the combined swab sampling structure comprises a swab sampling structure integrated on a probe tube or an outer sheath of the probe body, and a sample withdrawal structure for withdrawing the swab sampling structure from the probe tube or the outer sheath, the swab sampling structure comprises

[0009] a fixing member attached to an end of the probe tube or the outer sheath of the probe body;

[0010] a sampling layer, which is a flocked swab layer fixed to an outer surface of the fixing member; and

[0011] a connecting unit for fixing the fixing member to the end of the probe tube or the outer sheath.

[0012] In the present application, the fixing member with the flocked swab layer is fixed to the end face of the outer sheath by the connecting unit, and the installation is firm and reliable; in use, the optimal collection position can be scanned and determined by the OCT probe, and since the flocked swab layer is integrated on the probe, the cell sample at the optimal collection position can be directly obtained, that is, the high-precision sampling for HPV pathological detection is completed by directly using the OCT scanning technology, which not only avoids the discomfort caused by the sampling brush, but also ensures the precision of the sampling position, reduces the missed detection rate of HPV pathological detection as much as possible, and has important popularization value.

[0013] In a preferred embodiment of the present application, the connecting unit comprises a ring-shaped sleeve fixed to the edge of the fixing member. More preferably, the sample withdrawal structure comprises a sampling tube and a sample withdrawal member for dropping the fixing member into the sampling tube, the sample withdrawal member has a first through hole through which the probe tube or the outer sheath passes and a second through hole in communication with the first through hole, and the diameter of the second through hole is smaller than the outer diameter of the probe tube or the outer sheath. During sample withdrawal, the probe tube and the swab sampling structure at the end thereof are first inserted into the sampling tube through the first through hole (i.e. the avoiding port), and the ring-shaped sleeve is subjected to a reverse force through the second through hole with a smaller diameter, so that the ring-shaped sleeve falls off from the probe tube under the action of the reverse force during the upward movement of the probe tube, and directly falls into the sampling tube with the reagent, realizing contactless sample withdrawal of the swab sampling structure, reducing the probability of sample contamination, and further improving the reliability of the detection result.

[0014] In another preferred embodiment of the present application, the fixing member is a plurality of fixing members, the fixing member comprises a swab part and a fixing part which are integrally formed, the connecting unit comprises a plurality of mounting grooves which are formed at the edge of the end face of the probe tube or the outer sheath, the swab part is clamped in the mounting groove one by one, and the fixing part is attached to the probe tube or the outer sheath. More preferably, the sample removal structure comprises a sampling tube and a sample removal member which makes the fixing member fall into the sampling tube, the sample removal member has a first through hole through which the probe tube or the outer sheath passes, and the hole of the first through hole is communicated with a second through hole corresponding to the fixing part one by one. The second through hole and the first through hole are clearance holes, so that the fixing member on the probe tube or the outer sheath smoothly enters the sampling tube. When the sample is removed, the fixing part and the second through hole are misaligned by appropriately rotating the probe tube, and the fixing part is detached from the outer sheath under the block of the sample removal member and falls into the sampling tube below, thereby realizing non-contact sample removal of the swab sampling structure, reducing the probability of contamination, and improving the reliability of the detection result.

[0015] In another preferred embodiment of the present application, the end face of the probe tube or the outer sheath is provided with a mounting groove, and the fixing member is arranged in the mounting groove; the connecting unit comprises at least one pair of arc-shaped limiting grooves formed on the boss of the end face and at least one pair of limiting pieces fixed at the edge of the fixing member, and the arc-shaped limiting groove is communicated with the mounting groove so that the limiting piece moves in the corresponding arc-shaped limiting groove. More preferably, the fixing member is provided with at least one pair of dismounting holes; the sample removal structure comprises a sampling member having a receiving groove, and the bottom wall of the sampling member is provided with a dismounting column corresponding to the dismounting hole one by one. In this scheme, the dismounting column is inserted into the dismounting hole of the swab sampling structure, and then the sampling member is rotated to move the limiting piece of the fixing member out of the arc-shaped limiting groove, so that the fixing piece is detached from the outer sheath and falls onto the dismounting column.

[0016] More preferably, the end of the dismounting column can adopt a stepped structure, and the larger diameter step surface can be abutted against the surface of the fixing piece, and the small head of the dismounting column is inserted into the dismounting hole, so as to ensure that the dismounting column is inserted in place.

[0017] Compared with the prior art, the fixing member with the flocked swab layer is integrated on the end face of the outer sheath (of course, the probe tube) of the endoscope probe, which is firmly and reliably installed and successfully avoids the LED lamp window, the optical scanning window and the endoscope window on the probe body, thereby ensuring the normal use of the dual-mode endoscope probe. In the TCT and HPV detection sampling, the OCT technology is used to determine the optimal sampling position and synchronously obtain the sample at the position, thereby improving the accuracy of the cervical cancer TCT detection and HPV virus detection and reducing missed diagnosis. The flocked swab layer is integrated on the end face of the probe body, thereby reducing the discomfort. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 is a schematic diagram of the existing sampling brush for HPV sampling.

[0019] Figure 2 is a schematic diagram of the structure of the first embodiment of the present application.

[0020] Figure 3 is a schematic diagram of the sampling structure of the first embodiment. Figure 2 is an enlarged view of part A in figure 9.

[0021] Figure 4 is a schematic diagram of the sampling structure of the first embodiment.

[0022] Figure 5 is a diagram of the relationship between the sampling structure and the outer sheath (the limiting sheet is located at the arc-shaped inlet and outlet).

[0023] Figure 6 is a diagram of the relationship between the sampling structure and the outer sheath (the limiting sheet is located at the arc-shaped limiting slot).

[0024] Figure 7 is a diagram of the use state of the sampling structure of the first embodiment.

[0025] Figure 8 is a schematic diagram of the structure of the second embodiment of the present application. Figure 7 is an enlarged view of part B in figure 9.

[0026] Figure 9 is a schematic diagram of the structure of the second embodiment of the present application.

[0027] Figure 10 is an enlarged view of part C in figure 9.

[0028] Figure 11 is a side view of the sampling structure in figure 9. Figure 10

[0029] is a schematic diagram of the sampling structure of the second embodiment. Figure 12

[0030] is a top view of the sampling cover in figure 9. Figure 13 Figure 12 is a diagram of the use state of the sampling structure of the second embodiment (the probe body is inserted into the sampling tube from the first perforation).

[0031] Figure 14 is a diagram of the use state of the sampling structure (the probe body is rotated to the second perforation, and the annular sleeve is blocked during the upward movement of the probe body).

[0032] Figure 15 is a schematic diagram of the third embodiment of the present application.

[0033] Figure 16 is a schematic diagram of the third embodiment of the present application.

[0034] Figure 17 Figure 16 ​​Enlarged view of the middle D portion.

[0035] Figure 18 is Figure 17 Side view of the middle swab sampling structure.

[0036] Figure 19 is a schematic diagram of the sample withdrawal structure in the third embodiment of the present application.

[0037] Figure 20 is Figure 19 Top view of the sample withdrawal structure.

[0038] Figure 21 is a use state diagram of the sample withdrawal structure in the third embodiment of the present application.

[0039] Figure 22 is a sample withdrawal state diagram of the third embodiment (the fixed portion is misaligned with the second perforation). DETAILED DESCRIPTION

[0040] The embodiments of the present application will be described in detail below with reference to the accompanying drawings, which are implemented on the premise of the technical solutions of the present application, and give detailed implementation modes and specific operation processes, but the protection scope of the present application is not limited to the following embodiments.

[0041] It should be noted that the probe body in the following embodiments is a dual-mode optical scanning endoscopic probe (such as CN217338538U and CN115299885A), and the present application makes more detailed description of the integrated dual-mode optical scanning endoscopic probe based on CN115299885A.

[0042] Embodiment I The present application provides an integrated dual-mode optical scanning endoscopic probe, which comprises a probe body and a combined sampling structure, the combined sampling structure comprising a swab sampling structure integrated on the probe body and a sample withdrawal structure for removing the swab sampling structure from the probe body. The present application integrates the swab sampling structure on the probe body, so that the biopsy sample can be obtained at the same time as the OCT scanning, only one operation is needed, and the operation steps of the existing sampling are simplified; in addition, after the scanning and sampling are completed, the swab layer can be stored without contact, reducing the external environment.

[0043] Specifically, in combination with Figure 2It can be seen that the probe body includes a probe seat 101, a probe tube 102 and an optical assembly, the mirror 103, the collimating mirror 104 and the galvanometer 105 of the optical assembly are installed in the probe seat 101, and the optical fiber 106 is arranged on the probe seat 101; the lens 107 and the endoscope assembly of the optical assembly are arranged in the probe tube 102, the light path of the lens 107 is an eccentric light path, so as to facilitate the installation of the endoscope assembly (including an LED lamp and a camera); the outer sheath 108 is sleeved on the probe tube 102, the outer sheath 108 and the probe tube 102 are detachably connected, and the contactless replacement of the outer sheath 108 can be realized; the end faces of the probe tube 102 and the outer sheath 108 are both inclined surface structures.

[0044] In combination Figures 3-6 It can be seen that the swab sampling structure 200 includes a fixing piece, a sampling layer and a connecting unit, the fixing piece is a fixing sheet 201 attached to the end face of the outer sheath 108, and the fixing sheet 201 is provided with through holes corresponding to the LED lamp window 109, the optical scanning window 110 and the endoscope window 111 of the end face of the outer sheath 108, so as to ensure the normal use of the probe body.

[0045] The sampling layer is a flocked swab layer fixed to the outer surface of the fixing sheet 201, and tightly adheres to the end face (i.e. the inclined surface) of the outer sheath through the fixing sheet; the connecting unit fixes the fixing sheet 201 with the flocked swab layer to the end face of the outer sheath 108, so as to ensure the reliable connection of the fixing sheet 201 and the outer sheath 108.

[0046] In combination Figure 5 It can be seen that the end face of the outer sheath 108 is provided with a mounting groove, the fixing sheet 201 is embedded in the mounting groove and the outer surface thereof is flush with the boss 108.1 of the end face of the outer sheath 108; the connecting unit includes a pair of arc-shaped limiting grooves 202 spaced apart on the boss 108.1 and a pair of limiting sheets 203 (semi-circular structure) fixed at the edges of the fixing sheet 201, the arc-shaped limiting grooves 202 are communicated with the mounting groove and have arc-shaped entrances and exits 204 with the same structure as the limiting sheets 203, the positions of the limiting sheets 203 and the arc-shaped entrances and exits 204 correspond to each other, the limiting sheets 203 are aligned with the arc-shaped entrances and exits 204, and then the fixing sheet 201 is rotated to make the limiting sheets 203 clamped in the arc-shaped limiting grooves 202 (as shown in Figure 6

[0047] In combination Figure 4 , 7 ​As shown in Figure 8, the fixing plate 201 has a pair of disassembly holes 301; the sample removal structure 300 includes a sampling component (i.e., a sampling cover 302) with a receiving groove. The bottom wall of the sampling cover 302 is provided with disassembly posts 303 corresponding to the disassembly holes 301. The disassembly posts 303 are vertically arranged inside the sampling cover 302. The end of the disassembly post 303 is a stepped structure. The larger diameter step surface rests on the surface of the fixing plate 201, and the smaller diameter step head is inserted into the disassembly hole 301 to ensure that the disassembly post 303 is inserted in place.

[0048] When in use, the outer sheath 108 with the swab sampling structure (a disposable sterile consumable) is installed on the probe tube 102 of the probe body. Then, the scanning is performed according to the conventional operation of OCT to determine the optimal sampling position. Since the swab sampling structure is integrated into the scanning end face of the OCT probe through the outer sheath 108, the sample at the optimal sampling position can be obtained at the same time as the optimal sampling position is determined, which improves the accuracy.

[0049] After the inspection, remove the swab sampling structure from the outer sheath 108 of the probe body: align the sampling cap 302 with the end face of the outer sheath 108, and insert the disassembly pins 303 into the disassembly holes 301 on the fixing plate 201 one by one, as follows: Figures 7-8 As shown; after the disassembly column 303 is inserted into place, place the probe tube 102 in a vertical position with the end facing down, and then rotate the sampling cover 302 counterclockwise to unscrew the limiting piece 203 at the edge of the fixing piece 201 out of the arc-shaped limiting groove 202, so that the fixing piece 201 falls from the outer sheath 108 into the disassembly column 303 of the sampling cover 302; then, screw the sampling cover 302 upside down onto the reagent tube, and the sampling unit after sampling will automatically fall into the reagent tube, realizing non-contact sampling.

[0050] Implementation Method Two: The integrated dual-modal optical scanning endoscope probe described in this implementation method

[0051] The integrated dual-modal optical scanning endoscope probe described in this embodiment differs from that in Embodiment 1 in that the connecting unit and the sample removal structure are structurally different. Specifically: as follows: Figures 9-11 As shown, the connecting unit in this embodiment includes an annular sleeve 205 fixed at the edge of the fixing piece 201, the direction of the annular sleeve 205 being consistent with the direction of the outer sheath 108; the fixing piece 201 with a flocked swab layer is fixed to the end of the outer sheath 108 through the annular sleeve 205, and the fixing piece 201 is attached to the end face of the outer sheath 108; the three through holes on the fixing piece 201 correspond one-to-one with the LED light window 109, the optical scanning window 110 and the endoscope window 111 of the probe body, ensuring the normal use of the probe.

[0052] Combination Figure 12 , 13It can be seen that the sample returning structure in the embodiment includes a sampling tube 304.1 (the sampling tube 304.1 can adopt an existing HPV sample storage tube which is internally encapsulated with a storage reagent) and a sample returning element (i.e. a sample returning cover 305.1) for dropping the swab sampling structure into the sampling tube 304.1, and the sample returning cover 305.1 and the sampling tube 304.1 are screw-connected or snap-connected; the sample returning cover 305.1 is provided with a first perforation 306.1 (i.e. a swab avoiding port) for allowing the probe tube 102 to pass through and a second perforation 307.1 which is in communication with the first perforation 306.1, and the diameter of the second perforation 307.1 is smaller than the diameter of the probe tube 102, so that the probe tube 102 can rotate around the swab avoiding port and be attached to the hole edge of the second perforation 307.1, so as to facilitate the contactless taking of the swab sampling structure.

[0053] The swab sampling structure and the outer sheath 108 in the embodiment are disposable sterile consumables, and the swab sampling structure and the outer sheath 108 are an integrated finished product connected together when leaving the factory; the sample returning structure is also a disposable sterile consumable, and the sample returning structure is separately encapsulated when leaving the factory.

[0054] In use, the outer sheath 108 (a disposable sterile consumable) with the swab sampling structure is installed on the probe tube 102 of the probe body, and then the OCT is scanned according to the conventional operation and the optimal sampling position is determined. Since the swab sampling structure is integrated on the scanning end surface of the OCT probe through the outer sheath 108, the sample at the position can be obtained at the same time when the optimal sampling position is determined, so that the accuracy is improved.

[0055] After the examination is completed, the probe tube 102 of the probe body is taken out from the body, and the swab sampling structure is taken out by the sample returning structure and placed in the sampling tube 304.1: the probe tube 102 is passed through the swab avoiding port from top to bottom so that the swab sampling structure is completely located in the sampling tube 304.1 (which has a reagent for storing the sample) inside, as shown in Figure 14 ; the probe body is rotated so as to move from the swab avoiding port to the second perforation 307.1, and the swab sampling structure on the outer sheath 108 is ensured to be located in the sampling tube 304.1, as shown in Figure 15 ; the probe tube 102 is lifted upward, the hole edge of the second perforation 307.1 gives the annular sleeve 205 a downward reverse force, the annular sleeve 205 is detached from the outer sheath 108 under the action of the reverse force, so that the fixing sheet 201 with the flocked swab layer falls into the sampling tube 304.1, then the sample returning cover 305.1 is removed and a sterile sealing cover is screwed on the sampling tube 304.1, so that the contactless sampling of the swab sample is realized.

[0056] Embodiment three: the integrated dual-mode optical scanning endoscopic probe

[0057] The integrated dual-mode optical scanning endoscope probe of the embodiment differs from the first embodiment in that the structure of the fixing member, the connecting unit and the sample removal structure is different. Specifically:

[0058] As shown in Figures 16-18 The connecting unit includes three (of course, it can also be four, five or more) mounting grooves arranged at the edge of the end face of the outer sheath 108; the fixing member corresponds to three (of course, it can also be four, five or more), each fixing member has a swab part 308.1 with a flocked swab layer and a fixing part 308.2 extending along the length direction of the outer sheath 108, the swab part 308.1 is clamped in the mounting groove and the fixing part is attached to the outer sheath 108, thereby achieving effective fixation of the fixing member on the outer sheath 108.

[0059] In combination Figures 19-20 It can be seen that the sample removal structure in the embodiment includes a sampling tube 304.2 (the sampling tube 304.2 can adopt an existing commercially available HPV sample storage tube, which is encapsulated with a storage reagent) and a sample removal member (i.e. a sample removal cover 305.2) that allows the swab sampling structure to fall into the sampling tube 304.2, and the sample removal cover 305.2 and the sampling tube 304.2 are screw-connected or snap-connected; the sample removal cover 305.1 is provided with a first perforation 306.2 (i.e. a swab avoiding port) for allowing the probe tube 102 to pass through and a plurality of second perforations 307.2 in communication with the first perforation 306.2, the positions of the second perforations 307.2 correspond to the three fixing parts one by one and ensure that the fixing parts 308 can pass through the second perforations 307.2, so as to ensure contactless sample removal.

[0060] In use, the outer sheath 108 with the swab sampling structure (a disposable sterile consumable) is installed on the probe tube 102 of the probe body, and then the OCT routine operation is performed for scanning and determining the optimal sampling position. Since the swab sampling structure is integrated on the scanning end face of the OCT probe through the outer sheath 108, the sample at the position can be obtained at the same time as the optimal sampling position is determined, thereby improving the accuracy.

[0061] After the examination is completed, the probe tube 102 is taken out of the body, and the swab sampling structure is taken out by the sample removal structure and placed in the sampling tube 304.2: the sterile sample removal cover 305.2 is screwed on the sampling tube 304.2, the probe tube 102 is aligned with the first perforation 306.2, and the fixing part 308.2 is aligned with the second perforation 307.2, so as to ensure that the swab sampling structure enters the inside of the sampling tube 304.2, as shown in Figure 21 Then, the probe tube 102 is rotated by a certain angle to misalign the fixing part 308.2 with the second perforation 307.2, as shown in Figure 22; the first perforation 306.2 exerts an upward force on the fixed part 308.2, the swab sampling structure is separated from the outer sheath 108 under the action of the counterforce, the fixed part with the flocked swab layer falls into the sampling tube 304.2 below the sample cover 305.2, then the sample cover 305.2 is removed and a sterile sealing cover is screwed on the sampling tube 304.2, thus realizing contactless sampling.

[0062] In actual processing, the outer sheath 108 is a disposable sterile consumable, and the swab sampling structure is also a disposable sterile consumable. In order to avoid touching the swab sampling structure by hand as much as possible, the swab sampling structure is pre-installed on the outer sheath 108 before leaving the factory, and only the outer sheath 108 needs to be installed on the probe tube 102 when used; the sample withdrawal structure is also a disposable sterile consumable, which can be sterilized and packaged separately when leaving the factory.

[0063] In summary, the fixed part with the flocked swab layer is fixed at the entire end face or the edge of the end face of the outer sheath 108, which is firm and reliable in installation, and can avoid the LED light window, optical scanning window and endoscope window on the probe body, ensuring the normal use of the probe body. In TCT and HPV detection sampling, the OCT technology is used to determine the optimal sampling position and synchronously obtain the sample at the position, which improves the accuracy of cervical cancer TCT detection and HPV virus detection, reduces missed diagnosis, integrates the flocked swab layer on the end face of the probe body, reduces discomfort, and overcomes the technical defects of the existing sampling brush, such as high missed detection rate and strong discomfort.

[0064] Finally, it should be emphasized that the above only describes the preferred embodiments of the present application and is not intended to limit the present application. Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments without creative labor, or replace some technical features with equivalent ones. Thus, any modification, equivalent replacement, improvement, etc. within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A dual modality optical scanning endoscopy probe integrated with HPV sampling function, comprising a probe body; characterized in that: Also included is a combined swab sampling structure, which includes a swab sampling structure integrated on a probe tube or outer sheath of a probe body, and a sampling withdrawal structure for dropping off the swab sampling structure from the probe tube or outer sheath, the swab sampling structure including a fixing member attached to an end surface of the probe tube or outer sheath of the probe body; a sampling layer, which is a flocked swab layer fixed to an outer surface of the fixing member; and a connecting unit for fixing the fixing member to the end of the probe tube or outer sheath; wherein an installation groove is formed on the end surface of the probe tube or outer sheath, and the fixing member is arranged in the installation groove; the connecting unit includes at least one pair of arc-shaped limiting grooves formed on the bosses of the end surface and at least one pair of limiting pieces fixed at the edges of the fixing member, the arc-shaped limiting grooves being in communication with the installation groove so that the limiting pieces move in the corresponding arc-shaped limiting grooves, respectively; at least one pair of dismounting holes are formed on the fixing member; the sampling withdrawal structure includes a sampling member with a receiving groove, and a dismounting column is arranged on the bottom wall of the sampling member corresponding to the dismounting holes.

2. The dual modality optical scanning endoscopic probe integrated with HPV sampling function of claim 1, wherein: The connecting unit is replaced by a ring-shaped sleeve fixed at the edges of the fixing member; the sampling withdrawal structure includes a sampling tube and a sampling withdrawal member for dropping the fixing member into the sampling tube, the sampling withdrawal member having a first through hole for the probe tube or outer sheath to pass through and a second through hole in communication with the first through hole, the diameter of the second through hole being smaller than the outer diameter of the probe tube or outer sheath.

3. The dual modality optical scanning endoscopic probe integrated with HPV sampling function of claim 1, wherein: The fixing member is a plurality of members, each including an integrally formed swab portion and a fixing portion; the connecting unit is replaced by a plurality of installation grooves formed at the edges of the end surface of the probe tube or outer sheath, the swab portion being fitted in the installation groove one by one, and the fixing portion being attached to the probe tube or outer sheath; the sampling withdrawal structure includes a sampling tube and a sampling withdrawal member for dropping the fixing member into the sampling tube, the sampling withdrawal member having a first through hole for the probe tube or outer sheath to pass through, and a second through hole corresponding to the fixing portion is formed in the hole along the first through hole. The fixing member is a plurality of members, each including an integrally formed swab portion and a fixing portion; the connecting unit is replaced by a plurality of installation grooves formed at the edges of the end surface of the probe tube or outer sheath, the swab portion being fitted in the installation groove one by one, and the fixing portion being attached to the probe tube or outer sheath; the sampling withdrawal structure includes a sampling tube and a sampling withdrawal member for dropping the fixing member into the sampling tube, the sampling withdrawal member having a first through hole for the probe tube or outer sheath to pass through, and a second through hole corresponding to the fixing portion is formed in the hole along the first through hole.

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