A composite medical patch and its preparation method and application

Abstract

The present invention relates to a composite medical patch and a preparation method and application thereof. The composite medical patch comprises a base layer and an adhesive material layer; the adhesive material layer is at least one of a polydopamine adhesive material, a cyanoacrylate adhesive material, a polyurethane adhesive material, a chitosan adhesive material and a gelatin adhesive material. The patch has the advantages of both adhesive materials and medical patches, and while providing support for mechanical properties, avoids stitching and directly adopts an adhesive repair method to accelerate wound healing and prevent infection. The spin coating method adopted by the present invention is easy to operate and low in cost.

Description

Technical Field

[0001] The present invention relates to the field of biomedical materials, and more specifically to a composite medical patch and a preparation method and application thereof. Background Art

[0002] As the global population ages, chronic diseases that plague humans are becoming more prominent, leading to more and more human tissue problems. At the same time, with the continuous development of emerging technologies (tissue engineering, nanotechnology, information, surface modification, etc.) and materials medicine, more and more materials are entering the medical field as biomedical materials to repair defects in various parts of the human body. Medical patches are one of them. At present, general surgery is the most widely used medical patch, mainly in the fields of hernia repair, pelvic floor repair, chest wall defect repair, etc.

[0003] Medical patches can act as cell scaffolds during tissue repair and provide mechanical support for tissues and organs. In actual use, medical patches usually need to be fixed in the defective or diseased tissue area. Traditional fixation methods use sutures, staples or spiral staples to penetrate the tissue to achieve this. The process is time-consuming and cannot achieve rapid closure of the wound and immediate hemostasis. Repeated suture removal and dressing changes cause physical discomfort to patients and are prone to postoperative infection and complications. Therefore, we urgently need a medical tissue material that has the advantages of simple operation, non-invasive adhesion, instant sealing and hemostasis, which can replace the suture method. Therefore, there is an urgent need to give medical surgical patches a new attribute, that is, strong adhesion properties to biological tissues. Summary of the invention

[0004] In view of the problem that traditional patches must use devices that penetrate tissues, such as needle and thread suturing and surgical screws, to treat and repair tissue damage, one of the purposes of the present invention is to provide a composite medical patch that has the advantages of both adhesive materials and medical patches. While meeting the mechanical properties to provide support, it avoids needle and thread suturing and adopts a direct bonding repair method to accelerate wound healing and prevent infection.

[0005] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0006] A composite medical patch comprises a base layer and an adhesive material layer; the adhesive material layer is at least one of polydopamine adhesive materials, cyanoacrylate adhesive materials, polyurethane adhesive materials, chitosan adhesive materials and gelatin adhesive materials.

[0007] In the above technical solution, the material of the base layer can be selected from various medical polymer materials commonly used in medical patches in the prior art, preferably including at least one of polypropylene and polytetrafluoroethylene.

[0008] In the above technical solution, the base layer is a textile of the medical polymer, and its longitudinal density is 20 to 100 rows / 5 cm, and the transverse density is 10 to 70 wales / 5 cm; preferably, its longitudinal density is 60 to 90 rows / 5 cm, and the transverse density is 30 to 50 wales / 5 cm. The number of coils within a specified area of ​​a knitted fabric is usually expressed as PA×PB. Among them, the transverse density PA is expressed by the number of wales of coils within a specified length along the row direction of the knitted fabric coils. The longitudinal density PB is expressed by the number of wales of coils within a specified length along the wale direction of the knitted fabric coils.

[0009] In the above technical solution, the strong adhesion material layer is preferably a polydopamine adhesive material. The polydopamine material is selected because dopamine has good biocompatibility, can be adsorbed on the surface of almost any material, has high adaptability, and its preparation process is relatively simple.

[0010] In the above technical solution, the thickness of the adhesive material layer is 10-100 μm, preferably 40 μm;

[0011] The thickness of the base layer is 1-10 mm, preferably 2-5 mm.

[0012] The second object of the present invention is to provide a method for preparing the composite medical patch, which has the advantages of simple operation, low cost, high precision and strong repeatability.

[0013] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0014] A method for preparing a composite medical patch comprises: first preparing a patch base layer, then preparing an adhesive material spin coating solution, and then spin coating the adhesive material spin coating solution onto the base layer using a spin coater to obtain the composite medical patch.

[0015] In the above technical solution, the preparation of the spin coating solution of the adhesion material includes: dissolving the adhesion material, adding periodate, adjusting the pH to 7-8 and standing for 6-12 hours.

[0016] Preferably, the preparation method further comprises drying the product for 6-12 hours and then transferring it to a freeze dryer for 12-18 hours. Freeze drying can further remove residual organic molecules without destroying the material structure.

[0017] In the above technical solution, the preparation method of the patch base layer can be carried out by a common preparation method in the prior art. For example, it can be obtained by spinning polymer fibers. The present invention preferably prepares the patch base layer by the following steps:

[0018] Medical polymers (such as polypropylene and / or polytetrafluoroethylene) are melt-spun and then heat-treated under a stretched state to form polymer monofilaments. The process flow is: medical polymer slices - melt spinning machine extrusion spinning - cold water bath cooling - hot water bath drawing - hot air drawing - air heat setting - winding. After that, the medical polymer monofilaments are spun to prepare the patch base layer.

[0019] The polymer monofilament spinning can adopt the spinning process and conditions commonly used in the prior art.

[0020] A preferred method for spinning medical polymer monofilaments may include: controlling the spinning temperature between 270-285°C, the melt enters the cooling water tank through the spinning assembly, the water tank temperature is controlled at about 30°C, the first-stage hot water drawing temperature is controlled between 85-95°C, and the second-stage hot air drawing temperature is controlled between 140-160°C. Specifically, the number of spinneret holes is 100-200, the spinneret hole diameter is between 0.5-1mm, the winding rate is 140m / min, the heat setting temperature is 100°C, the main machine pressure is 5-10MPa, the metering pump pressure is 2-3MPa, the screw speed is 20-30rpm, and the metering pump speed is 5-10rpm.

[0021] Preferably, the adhesive material is dissolved in an acidic buffered salt solution, and then periodate is added, and the periodate is preferably at least one of sodium periodate or potassium periodate; and the pH is adjusted to 7-8 and allowed to stand for 6-12 hours, and the pH is preferably 7; an alkaline solution is used to adjust the pH, preferably sodium hydroxide or potassium hydroxide.

[0022] In the above technical solution, the strong adhesion material in the spin coating solution is dissolved in the acidic buffered saline solution until dissolved, and the mass percentage concentration is preferably 1-20%, and more preferably 5-10%. If the concentration is too low, the prepared composite medical patch has low adhesion and cannot achieve the repair effect. On the contrary, if the concentration is too high, the adhesion material is easy to agglomerate on the surface of the polymer substrate and cannot be evenly dispersed. Therefore, a suitable concentration is required. The acidic buffered saline solution can adopt the acidic buffered saline solution commonly used in the prior art. The present invention preferably adopts a phosphate buffered saline solution, and its concentration is generally 5 to 20 mmol L -1 .

[0023] In the above technical solution, the amount of the spin coating solution on the substrate layer is 1-100 μL / cm 2 , preferably 20-50 μL / cm 2 .

[0024] In the above technical solution, the spin coating includes a first step of spin coating and a second step of spin coating, the first step of spin coating has a rotation speed between 500-2000r, preferably 1000-1500r; the second step of spin coating has a rotation speed between 2000-10000r, preferably 6000-8000r.

[0025] In the above technical solution, the first step of spin coating takes 10-120 seconds, preferably 60-90 seconds; the second step of spin coating takes 30-300 seconds, preferably 120-180 seconds. The two steps of spin coating at different speeds are used because the first step of low-speed spin coating can evenly spread the adhesive material, which is more conducive to further dispersion; because if the high-speed spin coating is directly used, the strongly adhesive material is easy to be unevenly dispersed.

[0026] The third object of the present invention is to provide the use of the above-mentioned composite medical patch in chest wall repair, pelvic floor repair or hernia repair.

[0027] Beneficial effects of the present invention:

[0028] 1) The composite medical patch prepared by the present invention has both the strong mechanical properties of a traditional patch and the strong adhesion properties of an adhesive.

[0029] 2) The composite medical patch prepared by the present invention has the advantages of simple operation, effective shortening of operation time, minimizing treatment damage, alleviating patient pain, preventing body fluid leakage, reducing secondary damage, etc. in actual surgery, and can provide physical support, accelerate wound healing, and prevent infection.

[0030] 3) The spin coating method adopted by the present invention is easy to operate and low in cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 The schematic diagram of the process of preparing the composite medical patch by the spin coating method of the present invention is shown. DETAILED DESCRIPTION

[0032] The present invention is described in detail below in conjunction with specific embodiments. It is necessary to point out that the following embodiments are only used to further illustrate the present invention and cannot be understood as limiting the scope of protection of the present invention. Some non-essential improvements and adjustments made to the present invention by those skilled in the art based on the contents of the present invention still fall within the scope of protection of the present invention.

[0033] It should also be noted that the various specific technical features described in the following specific embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not further describe various possible combinations.

[0034] In addition, the various embodiments of the present invention may be arbitrarily combined as long as they do not violate the concept of the present invention. The technical solutions thus formed belong to part of the original disclosure of this specification and also fall within the protection scope of the present invention.

[0035] Source of reagents: All reagents are commercially available.

[0036] One of the purposes of the present invention is to provide a composite medical patch which has the advantages of both adhesive materials and medical patches, provides support while meeting mechanical properties, avoids suturing and adopts a direct bonding repair method to accelerate wound healing and prevent infection.

[0037] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0038] A composite medical patch comprises a base layer and an adhesive material layer; the adhesive material layer is at least one of polydopamine adhesive materials, cyanoacrylate adhesive materials, polyurethane adhesive materials, chitosan adhesive materials and gelatin adhesive materials.

[0039] In the above technical solution, the material of the base layer can be selected from various medical polymer materials commonly used in medical patches in the prior art, preferably including at least one of polypropylene and polytetrafluoroethylene.

[0040] In the above technical solution, the base layer is a textile of the medical polymer, and its longitudinal density is 20 to 100 rows / 5 cm, and the transverse density is 10 to 70 wales / 5 cm; preferably, its longitudinal density is 60 to 90 rows / 5 cm, and the transverse density is 30 to 50 wales / 5 cm. The number of coils within a specified area of ​​a knitted fabric is usually expressed as PA×PB. Among them, the transverse density PA is expressed by the number of wales of coils within a specified length along the row direction of the knitted fabric coils. The longitudinal density PB is expressed by the number of wales of coils within a specified length along the wale direction of the knitted fabric coils.

[0041] In the above technical solution, the strong adhesion material layer is preferably a polydopamine adhesive material. The polydopamine material is selected because dopamine has good biocompatibility, can be adsorbed on the surface of almost any material, has high adaptability, and its preparation process is relatively simple.

[0042] In the above technical solution, the thickness of the adhesive material layer is 10-100 μm, preferably 40 μm;

[0043] The thickness of the base layer is 1-10 mm, preferably 2-5 mm.

[0044] The second object of the present invention is to provide a method for preparing the composite medical patch, which has the advantages of simple operation, low cost, high precision and strong repeatability.

[0045] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0046] A method for preparing a composite medical patch comprises: first preparing a patch base layer, then preparing an adhesive material spin coating solution, and then spin coating the adhesive material spin coating solution onto the base layer using a spin coater to obtain the composite medical patch.

[0047] In the above technical solution, the preparation of the spin coating solution of the adhesion material includes: dissolving the adhesion material, adding periodate, adjusting the pH to 7-8 and standing for 6-12 hours.

[0048] Preferably, the preparation method further comprises drying the product for 6-12 hours and then transferring it to a freeze dryer for 12-18 hours. Freeze drying can further remove residual organic molecules without destroying the material structure.

[0049] In the above technical solution, the preparation method of the patch base layer can be carried out by a common preparation method in the prior art. For example, it can be obtained by spinning polymer fibers. The present invention preferably prepares the patch base layer by the following steps:

[0050] Medical polymers (such as polypropylene and / or polytetrafluoroethylene) are melt-spun and then heat-treated under a stretched state to form polymer monofilaments. The process flow is: medical polymer slices - melt spinning machine extrusion spinning - cold water bath cooling - hot water bath drawing - hot air drawing - air heat setting - winding. After that, the medical polymer monofilaments are spun to prepare the patch base layer.

[0051] The polymer monofilament spinning can adopt the spinning process and conditions commonly used in the prior art.

[0052] A preferred method for spinning medical polymer monofilaments may include: controlling the spinning temperature between 270-285°C, the melt enters the cooling water tank through the spinning assembly, the water tank temperature is controlled at about 30°C, the first-stage hot water drawing temperature is controlled between 85-95°C, and the second-stage hot air drawing temperature is controlled between 140-160°C. Specifically, the number of spinneret holes is 100-200, the spinneret hole diameter is between 0.5-1mm, the winding rate is 140m / min, the heat setting temperature is 100°C, the main machine pressure is 5-10MPa, the metering pump pressure is 2-3MPa, the screw speed is 20-30rpm, and the metering pump speed is 5-10rpm.

[0053] Preferably, the adhesive material is dissolved in an acidic buffered salt solution, and then periodate is added, and the periodate is preferably at least one of sodium periodate or potassium periodate; and the pH is adjusted to 7-8 and allowed to stand for 6-12 hours, and the pH is preferably 7; an alkaline solution is used to adjust the pH, preferably sodium hydroxide or potassium hydroxide.

[0054] In the above technical solution, the strong adhesion material in the spin coating solution is dissolved in the acidic buffered saline solution until dissolved, and the mass percentage concentration is preferably 1-20%, and more preferably 5-10%. If the concentration is too low, the prepared composite medical patch has low adhesion and cannot achieve the repair effect. On the contrary, if the concentration is too high, the adhesion material is easy to agglomerate on the surface of the polymer substrate and cannot be evenly dispersed. Therefore, a suitable concentration is required. The acidic buffered saline solution can adopt the acidic buffered saline solution commonly used in the prior art. The present invention preferably adopts a phosphate buffered saline solution, and its concentration is generally 5 to 20 mmol L -1 .

[0055] In the above technical solution, the amount of the spin coating solution on the substrate layer is 1-100 μL / cm 2 , preferably 20-50 μL / cm 2 .

[0056] In the above technical solution, the spin coating includes a first step of spin coating and a second step of spin coating, the first step of spin coating has a rotation speed between 500-2000r, preferably 1000-1500r; the second step of spin coating has a rotation speed between 2000-10000r, preferably 6000-8000r.

[0057] In the above technical solution, the first step of spin coating takes 10-120 seconds, preferably 60-90 seconds; the second step of spin coating takes 30-300 seconds, preferably 120-180 seconds. The two steps of spin coating at different speeds are used because the first step of low-speed spin coating can evenly spread the adhesive material, which is more conducive to further dispersion; because if the high-speed spin coating is directly used, the strongly adhesive material is easy to be unevenly dispersed.

[0058] The third object of the present invention is to provide the use of the above-mentioned composite medical patch in chest wall repair, pelvic floor repair or hernia repair.

[0059] Example 1

[0060] Preparation of the patch base layer: The medical polypropylene monofilament (diameter 0.15mm) is produced by melt spinning and then heat treated under stretching. The process flow is: medical polypropylene slices - melt spinning machine extrusion spinning - cold water bath cooling - hot water bath drawing - hot air drawing - air heat setting - winding. Then the polypropylene monofilament is spun to prepare the patch base layer. Spinning process: The spinning temperature is controlled between 270-285℃, the melt passes through the spinning assembly and enters the cooling water tank, the water tank temperature is controlled at about 30℃, the first-level hot water stretching temperature is controlled between 85-95℃, and the second-level hot air stretching temperature is controlled between 140-160℃. Specifically, the number of spinneret holes is 100-200, the spinneret hole diameter is between 0.5-1mm, the winding speed is 140m / min, the heat setting temperature is 100℃, the main machine pressure is 5-10MPa, the metering pump pressure is 2-3MPa, the screw speed is 20-30rpm, and the metering pump speed is 5-10rpm. The vertical density of the base layer of the obtained patch is 50 horizontal rows / 5cm, and the horizontal density is 33 vertical rows / 5cm. All experimental materials are tested according to the national standard GB / T 6529 under standard atmospheric conditions (temperature 20±2.0℃, humidity 65±4% after humidity adjustment).

[0061] Weigh 40 mg of 6-hydroxydopamine hydrochloride and dissolve it in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmol L -1 The pH was adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand for 6-12 hours to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater was set to spin coat at a low speed of 500 rpm for 30 seconds to obtain a uniformly dispersed solution, and then the speed was increased to 3000 rpm for 60 seconds. The resulting composite patch was transferred to a vacuum drying oven, kept for 12 hours to dry, and then further transferred to a freeze dryer to stand for 12 hours. The thickness of the adhesion layer was 50 μm.

[0062] Example 2

[0063] After preparing the polypropylene patch by the method mentioned in Example 1, 50 mg of 6-hydroxydopamine hydrochloride was weighed and dissolved in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmol L -1The pH was adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 5%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater was set to spin coat at a low speed of 500 rpm for 30 seconds to obtain a uniformly dispersed solution, and then the speed was increased to 3000 rpm for 60 seconds. The resulting composite patch was transferred to a vacuum drying oven, kept for 12 hours to dry, and then further transferred to a freeze dryer to stand for 12 hours. The thickness of the adhesion layer was 80 μm.

[0064] Example 3

[0065] After preparing the polypropylene patch by the method mentioned in Example 1, 40 mg of 6-hydroxydopamine hydrochloride was weighed and dissolved in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmol L -1 The pH was adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater was set to spin coat at a low speed of 500 rpm for 60 seconds to obtain a uniformly dispersed solution, and then the speed was increased to 6000 rpm for 60 seconds. The resulting composite patch was transferred to a vacuum drying oven, kept for 12 hours to dry, and then further transferred to a freeze dryer to stand for 12 hours. The thickness of the adhesion layer was 40 μm.

[0066] Example 4

[0067] Medical polytetrafluoroethylene monofilament (diameter 0.15mm) is produced by melt spinning and then heat treated under stretching. The process is: medical polypropylene slices - melt spinning machine extrusion spinning - cold water bath cooling - hot water bath drawing - hot air drawing - air heat setting - winding. The conditions are similar to those of polypropylene monofilament spinning process. The spinning temperature is controlled between 270-285℃. The melt enters the cooling water tank through the spinning assembly. The water tank temperature is controlled at about 30℃. The first-level hot water drawing temperature is controlled between 85-95℃, and the second-level hot air drawing temperature is controlled between 140-160℃. The vertical density of the base layer of the obtained patch is 50 horizontal rows / 5cm, and the horizontal density is 33 vertical rows / 5cm. All experimental materials are tested according to the national standard GB / T6529 under standard atmospheric conditions (temperature 20±2.0℃, humidity 65±4% after humidity adjustment).

[0068] Weigh 40 mg of 6-hydroxydopamine hydrochloride and dissolve it in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4, and add 40mmol L -1 The pH was adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater was set to spin coat at a low speed of 500 rpm for 30 seconds to obtain a uniformly dispersed solution, and then the speed was increased to 3000 rpm for 60 seconds. The resulting composite patch was transferred to a vacuum drying oven, kept for 12 hours of drying, and then further transferred to a freeze dryer and allowed to stand for 12 hours. The thickness of the adhesive material layer was 50 μm.

[0069] Example 5

[0070] After preparing the polytetrafluoroethylene patch by the method mentioned in Example 4, 50 mg of 6-hydroxydopamine hydrochloride was weighed and dissolved in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmol L -1 The pH was adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 5%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater was set to spin coat at a low speed of 500 rpm for 30 seconds to obtain a uniformly dispersed solution, and then the speed was increased to 3000 rpm for 60 seconds. The resulting composite patch was transferred to a vacuum drying oven, kept for 12 hours of drying, and then further transferred to a freeze dryer and allowed to stand for 12 hours. The thickness of the adhesive material layer was 85 μm.

[0071] Example 6

[0072] After preparing the polytetrafluoroethylene patch by the method mentioned in Example 4, weigh 40 mg of 6-hydroxydopamine hydrochloride and dissolve it in 1 g of phosphate buffered saline with a concentration of 10 mmol L-1, then add 10 mg of sodium periodate NaIO4, and add 40 mmol L-1 of sodium hydroxide NaOH to adjust the pH to 7.0 and let it stand to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater is set to spin coat at a low speed of 500 rpm for 60 seconds to obtain a uniformly dispersed solution, and then increase the speed to 6000 rpm for 60 seconds. The resulting composite patch is transferred to a vacuum drying oven, kept for 12 hours, and then further transferred to a freeze dryer and left to stand for 12 hours. The thickness of the adhesive material layer is 45 μm.

[0073] Test Case

[0074] The composite medical patch prepared in the above example was subjected to a viscosity test and a mechanical property test, and the results are shown in Table 1 below.

[0075] The adhesion test method is to use a weight to adhere to a fixed area size patch (select 5cm 2 ) is suspended below the surface for testing, with the adhesion time greater than 60s as the standard, and the weight of the weight is recorded to detect its viscosity.

[0076] The mechanical test method is to use a fabric strength tester, refer to GB / T 3923.1-1997. The sample size is 250mm*50mm, the pre-tension is 2N, the clamping distance of the longitudinal sample is 200mm, the clamping distance of the transverse sample is 100mm, the tensile speed is 100mm / min, and the longitudinal and transverse tests are performed 10 times each.

[0077] Table 1

[0078]

[0079]

[0080] Comparative Example 1

[0081] After preparing the polypropylene patch by the method mentioned in Example 1, 150 mg of 6-hydroxydopamine hydrochloride was weighed and dissolved in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmolL -1 The pH is adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater is set to first spin coat at a low speed of 500 rpm for 60 seconds to obtain a uniformly dispersed solution, and then increase the speed to 6000 rpm and maintain for 60 seconds. The resulting composite patch is transferred to a vacuum drying oven, kept for 12 hours to dry, and then further transferred to a freeze dryer and allowed to stand for 12 hours. Compared with Example 1, the dopamine concentration in the comparative example is too high, so when the patch substrate is subsequently spin-coated, a large amount of dough is aggregated, which cannot be evenly dispersed and cannot form an effective protective layer.

[0082] Comparative Example 2

[0083] After preparing the polypropylene patch by the method mentioned in Example 1, 10 mg of 6-hydroxydopamine hydrochloride was weighed and dissolved in 1 g of 10 mmol L -1 10 mg sodium periodate NaIO 4 , and add 40mmol L -1The pH is adjusted to 7.0 with sodium hydroxide NaOH and allowed to stand to obtain a polydopamine solution with a mass percentage concentration of 4%. Use a pipette to accurately measure 100 μL of the solution and transfer it to the polymer substrate. The spin coater is set up to first spin coat at a low speed of 500 rpm for 60 seconds to obtain a uniformly dispersed solution, and then increase the speed to 6000 rpm and maintain for 60 seconds. The resulting composite patch is transferred to a vacuum drying oven, kept for 12 hours to dry, and then further transferred to a freeze dryer and allowed to stand for 12 hours. Compared with Example 1, the dopamine concentration used in the comparative example is too low, so the adhesion is too low when the patch substrate is subsequently spin-coated.

[0084] The present invention has been described in detail above in conjunction with specific implementations and exemplary examples, but these descriptions cannot be understood as limiting the present invention. Those skilled in the art understand that, without departing from the spirit and scope of the present invention, a variety of equivalent substitutions, modifications or improvements may be made to the technical solution of the present invention and its implementation methods, all of which fall within the scope of the present invention. The scope of protection of the present invention shall be subject to the attached claims.

Claims

1. A composite medical patch, comprising a base layer and an adhesive material layer; The adhesive material layer is a polydopamine adhesive material; The base layer is a textile of a medical polymer, the longitudinal density of which is 20 to 100 rows / 5 cm, and the transverse density of which is 10 to 70 longitudinal rows / 5 cm; the medical polymer is selected from at least one of polypropylene and polytetrafluoroethylene; The preparation method of the composite medical patch comprises: Firstly, a patch base layer is prepared, then a spin coating solution of an adhesive material is prepared, and then the spin coating solution of the adhesive material is transferred to the base layer and then spin coated on the base layer to obtain the composite medical patch; The mass percentage concentration of the adhesion material in the spin coating solution is 4-10%; The spin coating comprises a first step of spin coating and a second step of spin coating, wherein the first step of spin coating has a rotation speed between 500-2000 rpm; and the second step of spin coating has a rotation speed between 2000-10000 rpm.

2. The composite medical patch according to claim 1, characterized in that: The base layer has a vertical density of 60 to 90 horizontal rows / 5 cm, and a horizontal density of 30 to 50 vertical lines / 5 cm.

3. The composite medical patch according to claim 1, characterized in that: The thickness of the adhesive material layer is 10-100 μm; and / or, The thickness of the base layer is 1-10 mm.

4. The composite medical patch according to claim 3, characterized in that: The thickness of the adhesive material layer is 40 μm; and / or, The thickness of the base layer is 2-5 mm.

5. A method for preparing the composite medical patch according to any one of claims 1 to 4, comprising: Firstly, a patch base layer is prepared, and then an adhesive material spin coating solution is prepared. Then, the adhesive material spin coating solution is transferred to the base layer and then spin coated on the base layer to obtain the composite medical patch.

6. The preparation method according to claim 5, characterized in that: The mass percentage concentration of the adhesion material in the spin coating solution is 5-10%.

7. The preparation method according to claim 5, characterized in that: The amount of the spin coating solution applied to the substrate layer is 1-100 μL / cm 2 .

8. The preparation method according to claim 7, characterized in that: The amount of the spin coating solution applied to the substrate layer is 20-50 μL / cm 2 .

9. The method according to claim 5, characterized in that The spin coating comprises a first step of spin coating and a second step of spin coating, wherein the first step of spin coating has a rotation speed between 1000-1500 rpm; the second step of spin coating has a rotation speed between 6000-8000 rpm; and / or, The first step spin coating time is between 10-120 s; the second step spin coating time is between 30-300 s.

10. The method according to claim 9, characterized in that The first step spin coating time is between 60-90 s; the second step spin coating time is between 120-180 s.

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