A pushing device and a control method thereof, and a pushing dyeing machine

By combining the detection and processing units of the pusher device, the pusher parameters are determined based on the sample diffusion parameters, which solves the problem of poor quality of smears for samples with different viscosities and achieves the formation of high-quality smears.

CN116086906BActive Publication Date: 2025-11-28SHENZHEN REETOO BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202211622021.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-12-16
Publication Date
2025-11-28
Estimated Expiration
2042-12-16

AI Technical Summary

Technical Problem

In existing technologies, the smearing parameters cannot be adapted to samples with different viscosities, resulting in poor smear quality.

Method used

A slide pushing device is provided, including a conveying unit, a sample application unit, a detection unit, and a slide pushing unit. The device generates corresponding detection data by detecting the diffusion parameters of the sample on the glass slide. The processing unit determines the slide pushing parameters based on the detection data and controls the slide pushing unit to apply the sample onto the glass slide at the slide pushing position.

Benefits of technology

It enables matching of spreading parameters based on sample viscosity to ensure coating quality and meet high-quality coating standards.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application provides a slide pushing device and a control method thereof and a slide dyeing machine. The slide pushing device comprises a conveying unit, a sample adding unit, a detection unit, a processing unit and a slide pushing unit. The conveying unit comprises a conveying driving mechanism and a conveying bearing mechanism. The conveying bearing mechanism is used for bearing a slide. The conveying driving mechanism is connected with the conveying bearing mechanism to drive the conveying bearing mechanism to move. A slide pushing position is arranged along a movement track of the conveying bearing mechanism. The sample adding unit is used for adding a sample to the slide. The detection unit is used for detecting a diffusion parameter of the sample on the slide and generating corresponding detection data. The processing unit is used for determining a slide pushing parameter according to the detection data. The slide pushing unit is used for coating the sample on the slide at the slide pushing position according to the slide pushing parameter, so that the slide pushing unit can perform a slide pushing operation according to the slide pushing parameter corresponding to the viscosity of the sample, the slide pushing requirement corresponding to the viscosity of the sample is met, and the high-quality standard of a smear formed by coating the sample on the slide is ensured.
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Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a slide pushing device, a control method thereof and a slide dyeing machine. BACKGROUND

[0002] In the diagnosis and treatment of diseases, the sample is smeared on the slide to form a smear by pushing the slide, and then the smear is dyed to complete the preparation, and finally the microscopic detection is performed to obtain the detection result, which provides a reference basis for the doctor's diagnosis of the disease. For example, the microscopic detection of the smear is the basic method of liquid cytology detection, which is widely used, especially for the diagnosis of various liquid diseases.

[0003] In the prior art, in order to ensure that the smear has high quality standards such as appropriate thickness and uniform distribution, the slide pushing parameters such as the slide pushing angle and the slide pushing speed are set, so that the slide pushing is performed at the set slide pushing parameters. If the viscosity of the sample is different, for example, the viscosity of the sample is high, the thickness of the sample on the smear is thin, and the required slide pushing angle is small. Conversely, the required slide pushing angle is large. Therefore, for samples with different viscosities, if the same slide pushing parameters are used for slide pushing operation, the smear cannot meet the slide pushing requirements when the sample viscosity and the slide pushing parameters do not match. How to push out high-quality smears is a problem that needs to be solved. SUMMARY

[0004] The present application mainly provides a slide pushing device, a control method thereof and a slide dyeing machine, which can meet the slide pushing requirements corresponding to the sample viscosity.

[0005] To solve the above technical problems, one technical solution adopted by the present application is to provide a slide pushing device, which comprises: a conveying unit comprising a conveying driving mechanism and a conveying bearing mechanism, the conveying bearing mechanism being used to bear a slide, the conveying driving mechanism being connected with the conveying bearing mechanism to drive the conveying bearing mechanism to move, and a slide pushing position being arranged along the movement track of the conveying bearing mechanism; a sample adding unit used to add a sample to the slide; a detection unit used to detect the diffusion parameters of the sample on the slide and generate corresponding detection data; a processing unit in communication connection with the detection unit, the processing unit being used to receive the detection data of the detection unit and determine the slide pushing parameters according to the detection data; and a slide pushing unit used to smear the sample on the slide at the slide pushing position according to the slide pushing parameters.

[0006] In a specific embodiment, the processing unit is used to determine the viscosity of the sample according to the formula Y=kX -1 and determine the slide pushing parameters according to the viscosity of the sample, wherein Y represents the viscosity of the sample, k represents a coefficient, and X represents the slide pushing parameters.

[0007] In an embodiment, the slide pushing device further comprises a first drying unit connected to the processing unit in communication, and the processing unit is further configured to determine a first drying parameter according to the detection data corresponding to the diffusion parameter, and control the first drying unit to dry the slide after the slide pushing according to the first drying parameter.

[0008] In an embodiment, the processing unit is configured to control at least one of an air outlet angle, an air outlet speed and an air outlet time of the first drying unit according to the first drying parameter.

[0009] In an embodiment, the conveying and carrying mechanism is configured to carry a first slide, and the slide pushing device further comprises a carrying unit, the carrying unit comprising a detection and carrying mechanism, the conveying unit further comprising a first pushing driving mechanism and a first pushing member, the first pushing driving mechanism being connected to the first pushing member to drive the first pushing member to push the first slide from the conveying and carrying mechanism to the detection and carrying mechanism, the sample adding unit being configured to add a sample to the first slide, and the detection unit being configured to detect a diffusion parameter of the sample on the first slide and generate corresponding detection data.

[0010] In an embodiment, the carrying unit further comprises a second pushing driving mechanism and a second pushing member, the second pushing driving mechanism being connected to the second pushing member to drive the second pushing member to push the first slide after the detection from the detection and carrying mechanism to the conveying and carrying mechanism, and the slide pushing unit is configured to apply the sample to the first slide at the slide pushing position according to the slide pushing parameter.

[0011] In an embodiment, the conveying and carrying mechanism is further configured to carry a second slide, the sample adding unit is further configured to add the sample to the second slide, and the slide pushing unit is configured to apply the sample to the second slide at the slide pushing position according to the slide pushing parameter.

[0012] In an embodiment, the slide pushing device further comprises a recycling unit configured to recycle the first slide after the detection.

[0013] To solve the above technical problems, another technical solution adopted by the present application is to provide a slide pushing and dyeing machine, the slide pushing and dyeing machine comprising a dyeing device and a slide pushing device, and the processing unit is further configured to determine a dyeing parameter according to the detection data corresponding to the diffusion parameter, and control the dyeing device to dye the slide according to the dyeing parameter.

[0014] In a specific embodiment, the processing unit is configured to control at least one of a staining mode, a staining solution concentration, a staining time, a staining temperature, and a reagent type of the staining device according to the staining parameter; and / or the slide pushing and staining machine further comprises a second drying unit, and the processing unit is further configured to determine a second drying parameter according to the detection data corresponding to the diffusion parameter, and control the second drying unit to dry the slide after the staining according to the second drying parameter.

[0015] To solve the above technical problems, the application adopts another technical solution: providing a control method of a slide pushing device, the control method comprising: controlling a sample adding unit to add a sample to a slide; controlling a detection unit to detect a diffusion parameter of the sample on the slide and generate corresponding detection data; determining a slide pushing parameter according to the detection data; and controlling a slide pushing unit to apply the sample to the slide at a slide pushing position according to the slide pushing parameter.

[0016] The application has the following beneficial effects: Different from the prior art, the slide pushing device provided by the application comprises: a conveying unit comprising a conveying driving mechanism and a conveying bearing mechanism, the conveying bearing mechanism being configured to bear a slide, the conveying driving mechanism being connected to the conveying bearing mechanism to drive the conveying bearing mechanism to move, and a slide pushing position being arranged along a movement track of the conveying bearing mechanism; a sample adding unit configured to add a sample to the slide; a detection unit configured to detect a diffusion parameter of the sample on the slide and generate corresponding detection data; a processing unit communicatively connected to the detection unit, the processing unit being configured to receive the detection data of the detection unit and determine a slide pushing parameter according to the detection data; and a slide pushing unit configured to apply the sample to the slide at the slide pushing position according to the slide pushing parameter. The diffusion parameter reflects the viscosity of the sample, so that the slide pushing unit can perform a slide pushing operation according to the slide pushing parameter corresponding to the viscosity of the sample. Compared with the prior art, the slide pushing device meets the slide pushing requirement corresponding to the viscosity of the sample and ensures the high quality standard of a smear formed by applying the sample to the slide. BRIEF DESCRIPTION OF DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the application, the following will briefly introduce the drawings needed to be used in the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the application, and other drawings can also be obtained by those skilled in the art without any creative effort based on these drawings.

[0018] Figure 1 is a schematic diagram of the three-dimensional assembly structure of the slide pushing device provided by the application;

[0019] Figure 2 isFigure 1 A perspective exploded view of the pusher device;

[0020] Figure 3 A perspective view of the pusher device; Figure 2 A schematic block diagram of the detection unit;

[0021] Figure 4 A perspective view of the pusher device; Figure 1 A schematic block diagram of the pusher device in an embodiment;

[0022] Figure 5 A perspective view of the pusher device; Figure 2 A perspective assembly view of the conveying unit;

[0023] Figure 6 A perspective view of the pusher device; Figure 2 A perspective assembly view of the detection module and the bearing module in an embodiment;

[0024] Figure 7 A perspective view of the pusher device; Figure 6 A diffusion image of the sample collected by the detection unit in an embodiment;

[0025] Figure 8 A diffusion image of the sample collected by the detection unit in another embodiment; Figure 6 A diffusion image of the sample collected by the detection unit in another embodiment;

[0026] Figure 9 A perspective assembly view of the pusher module; Figure 2 A perspective view of the pusher and the slide in a pusher state;

[0027] Figure 10 A perspective assembly view of the detection unit and the bearing unit in another embodiment; Figure 9 A perspective assembly view of the pusher device in another embodiment;

[0028] Figure 11 A perspective assembly view of the pusher device in another embodiment; Figure 2 A perspective assembly view of the detection unit and the bearing unit in another embodiment;

[0029] Figure 12 A perspective assembly view of the pusher device in another embodiment; Figure 1 A perspective assembly view of the detection unit and the bearing unit in another embodiment;

[0030] Figure 13 A perspective assembly view of the detection unit and the bearing unit in another embodiment; Figure 2 A perspective exploded view of the first drying unit;

[0031] Figure 14 A perspective view of the pusher dyeing machine in an embodiment;

[0032] Figure 15 A perspective view of the pusher dyeing machine in an embodiment; Figure 14 A perspective view of the dyeing device;

[0033] Figure 16The control method is a control method of the pusher device provided in the application. DETAILED DESCRIPTION

[0034] The application will be described in further detail below in connection with the drawings and embodiments. It is particularly pointed out that the following embodiments are only for the purpose of illustrating the application, but not for limiting the scope of the application. Similarly, the following embodiments are only part of the embodiments of the application, but not all the embodiments of the application, and all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the application.

[0035] The terms "first", "second", "third" in the application are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features limited by "first", "second", "third" can explicitly or implicitly include at least one of the features. In the description of the application, the meaning of "a plurality of" is at least two, such as two, three, etc., unless otherwise specifically limited. All directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the application are only used to explain the relative positional relationship, movement condition, etc. between components in a certain posture (as shown in the drawings), and if the certain posture changes, the directional indications also change accordingly. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device including a series of steps or units is not limited to the listed steps or units, but can optionally include steps or units not listed, or can optionally include other steps or units inherent to the process, method, product or device.

[0036] In this document, the reference to "embodiment" means that the specific features, structures or characteristics described in connection with the embodiment can be included in at least one embodiment of the application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it mutually exclusive or alternative to other embodiments. Those skilled in the art explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0037] Please refer to Figure 1 , Figure 2 and Figure 3 , Figure 1 is a perspective assembly structure schematic diagram of an embodiment of the pusher device 10 provided in the application, Figure 2 is Figure 1 a perspective exploded structure schematic diagram of the pusher device 10 in Figure 3 is Figure 2A schematic block diagram of the detection unit 13, the pusher device 10 in the embodiment comprises a conveying unit 11, a sample adding unit 12, the detection unit 13, a processing unit 14 and a pusher unit 15.

[0038] Please refer to Figure 4 and Figure 5 , Figure 4 is Figure 1 A schematic block diagram of the position of an embodiment of the pusher device 10, Figure 5 is Figure 2 A schematic block diagram of the assembly structure of the conveying unit 11 in the embodiment, the conveying unit 11 comprises a conveying driving mechanism 111 and a conveying bearing mechanism 112, the conveying bearing mechanism 112 is used for bearing the slide 110, and the conveying driving mechanism 111 is connected with the conveying bearing mechanism 112 to drive the conveying bearing mechanism 112 to move.

[0039] Among them, the pusher position P1 is arranged along the movement track of the conveying bearing mechanism 112, that is, in actual application, the slide 110 is first borne on the conveying bearing mechanism 112, and then the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move, so as to convey the slide 110 to the pusher position P1.

[0040] Optionally, in the embodiment, the conveying driving mechanism 111 can be selected from a screw motor, an air cylinder and a belt motor, and the like, and the driving mode is not limited.

[0041] Please refer to Figure 6 , Figure 7 and Figure 8 , Figure 6 is Figure 2 A schematic block diagram of the assembly structure of an embodiment of the detection unit 13 and the bearing unit 16, Figure 7 is Figure 6 A diffusion image of an embodiment of the detection unit 13 collecting samples, Figure 8 is Figure 6 A diffusion image of another embodiment of the detection unit 13 collecting samples, the sample adding unit 12 is used for adding samples to the slide 110, and the detection unit 13 is used for detecting the diffusion parameters of the samples on the slide and generating corresponding detection data.

[0042] Specifically, in the embodiment, the detection unit 13 is used for collecting a diffusion image of the samples on the slide 110, and identifying the diffusion parameters of the samples on the slide 110 according to the diffusion image.

[0043] Optionally, the detection unit 13 can be a camera, a CCD element or a CMOS element, and the like, and the like, and the driving mode is not limited.

[0044] In this embodiment, the diffusion parameter can be at least one of diffusion length, diffusion width, diffusion area, and diffusion rate.

[0045] For example, Figure 7 As shown, when the diffusion image after sample diffusion is complete is circular ( Figure 7 The shaded area in the image represents the diffusion area of ​​the sample. The detection unit 13 acquires all images of the sample diffusion and determines the start image and the completion image of the sample diffusion. Based on the completion image of the sample diffusion, the radius R of the circular diffusion image is determined, and the diffusion area of ​​the sample is calculated. Alternatively, the start time t1 of the sample diffusion is determined based on the start image of the sample diffusion, the end time t2 of the sample diffusion is determined based on the completion image of the sample diffusion, and then the radius R of the circular diffusion image is determined based on the completion image of the sample diffusion. Finally, the diffusion speed v of the sample is determined according to the formula R / (t2-t1)=v.

[0046] For example, Figure 8 As shown, the diffusion image after sample diffusion is completed is linear. Figure 8 The shaded area in the image represents the diffusion area of ​​the sample. The detection unit 13 determines the length K1 or width K2 of the linear diffusion image based on the completed image of the sample diffusion; or, as mentioned above, first determine the start time t1 and the end time t2 of the sample diffusion, then determine the length K1 or width K2 of the linear diffusion image based on the completed image of the sample diffusion, and finally determine the diffusion speed v of the sample according to the formula K / (t2-t1)=v.

[0047] Please refer to the following: Figure 9 and Figure 10 , Figure 9 yes Figure 2 A schematic diagram of the three-dimensional assembly structure of the pusher module 122. Figure 10 yes Figure 9 A schematic diagram of the pushing state of the pusher 120 and the glass slide 110 is shown. The processing unit 14 is communicatively connected to the detection unit 13. The processing unit 14 is used to receive the detection data from the detection unit 13 and determine the pushing parameters based on the detection data. The pushing unit 15 is used to coat the sample onto the glass slide 110 at the pushing position P1 according to the pushing parameters. The diffusion parameters reflect the viscosity of the sample, so that the pushing unit 15 can perform the pushing operation according to the pushing parameters corresponding to the viscosity of the sample. Compared with the prior art, it meets the pushing requirements corresponding to the sample viscosity and ensures the high quality standard of the coating formed by coating the sample onto the glass slide 110.

[0048] The processing unit 14 is configured to determine the viscosity of the sample according to the detection data, and determine the pusher parameter according to the viscosity of the sample. In actual application, the correlation between the diffusion parameter and the viscosity of the sample and the pusher parameter can be stored in the processing unit 14 in advance, for example, as shown in the following table. Taking the diffusion speed of the sample as an example, when the detection unit 13 detects the diffusion speed V of the sample, the processing unit 14 can find the corresponding viscosity N according to the correlation, and then determine the pusher parameter M.

[0049] Diffusion speed V Viscosity Y Pusher parameter M V1 Y1 M1 V2 Y2 M2 V3 Y3 M3

[0050] In actual application, the correlation between the viscosity of the sample and the diffusion parameter can be obtained according to experimental test, or according to experience, or according to the formula Y=kX -1 , where Y represents the viscosity of the sample, k represents the coefficient, and X represents any one of the diffusion length, the diffusion width, the diffusion area and the diffusion speed.

[0051] Further, the pusher unit 15 comprises a first pusher driving mechanism 15a, a second pusher driving mechanism 15b and a pusher assembly 15c. The pusher assembly 15c is configured to mount the pusher 120. The second pusher driving mechanism 15b is connected with the first pusher driving mechanism 15a and the pusher assembly 15c, so that the first pusher driving mechanism 15a drives the pusher 120 to move away from or close to the slide 110 in the first pusher direction A, and the second pusher driving mechanism 15b drives the pusher 120 to spread the sample on the slide 110 in the second pusher direction B. In an embodiment, the first pusher direction A is the vertical direction, and the second pusher direction B is the horizontal direction.

[0052] The pusher parameter can be the pusher angle a as shown in Figure 9 , or the pusher speed of the pusher 120 in the second pusher direction B, or the distance L between the pusher 120 and the slide 110 in the first pusher direction A, or other pusher parameters. Therefore, in actual application, the pusher parameter can be set according to actual needs, which is not limited herein.

[0053] Optionally, in the embodiment, the first pusher driving mechanism 15a and the second pusher driving mechanism 15b are driven by a screw motor. In other embodiments, other driving modes can be used, such as a pneumatic cylinder, which is not limited herein.

[0054] Further referring to Figure 2 , Figure 4 , Figure 6 and Figure 11The pushing device 10 in the embodiment further comprises a carrying unit 16, the conveying carrying mechanism 112 is used for carrying the first slide, the carrying unit 16 comprises a detection carrying mechanism 161, the conveying unit 11 further comprises a first pushing driving mechanism 113 and a first pushing piece 114, the first pushing driving mechanism 113 is connected with the first pushing piece 114, so as to drive the first pushing piece 114 to push the first slide from the conveying carrying mechanism 112 to the detection carrying mechanism 161, the adding unit 12 is used for adding the sample to the first slide, and the detection unit 13 is used for detecting the diffusion parameter of the sample on the first slide and generating corresponding detection data.

[0055] In an embodiment as shown in the figure, Figure 6 The carrying unit 16 further comprises a second pushing driving mechanism 162 and a second pushing piece 163, the second pushing driving mechanism 162 is connected with the second pushing piece 163, so as to drive the second pushing piece 163 to push the first slide after detection from the detection carrying mechanism 161 to the conveying carrying mechanism 112, and the pushing unit 15 is used for applying the sample to the first slide according to the pushing parameter at the pushing position P1.

[0056] Specifically, when the detection unit 13 finishes detecting the sample on the first slide, the second pushing driving mechanism 162 drives the second pushing piece 163 to push the first slide after detection to the conveying carrying mechanism 112, and then the conveying driving mechanism 111 drives the conveying carrying mechanism 112 to move the first slide to the pushing position P1, so that the pushing unit 15 completes the pushing operation on the sample on the first slide according to the pushing parameter, so that the sample on the first slide can be used for detection and pushing operation, and waste of the sample is avoided.

[0057] In another embodiment as shown in the figure, Figure 11 The conveying carrying mechanism 112 is further used for carrying the second slide, the adding unit 12 is further used for adding the sample to the second slide, and the pushing unit 15 is used for applying the sample to the second slide according to the pushing parameter at the pushing position, that is, the detection unit 13 detects the sample on the first slide on the detection carrying mechanism 161, and the pushing unit 15 applies the sample to the second slide, so that the detection operation of the detection unit 13 and the pushing operation of the pushing unit 15 are not performed on the same slide, in this way, during the detection of the detection unit 13, the conveying driving mechanism 111 drives the conveying carrying mechanism 112 to move the second slide to the pushing position P2, without waiting for the detection of the detection unit 13 to be completed, so that the time of the whole process is saved, and the efficiency is improved.

[0058] Optionally, in the other embodiment, the push piece device 10 further comprises a recovery unit 17, which is used for recovering the first slide after detection. In actual application, the second slide can be pushed from the detection bearing mechanism 161 to the recovery unit 17 in the same way as the second push driving mechanism 162 and the second push piece 163.

[0059] Further, the push piece device 10 in the embodiment further comprises a slide storage unit 18, which is used for storing the first slide. A slide receiving position P2 and a slide pushing position P3 are further arranged along the movement track of the conveying bearing mechanism 112. The conveying bearing mechanism 112 is used for receiving the first slide stored in the slide storage unit 18 at the slide receiving position P2. The first push driving mechanism 113 is used for driving the first push piece 114 to push the first slide from the conveying bearing mechanism 112 to the detection bearing mechanism 161 at the slide pushing position P3.

[0060] Specifically, in actual application, the conveying driving mechanism 111 first drives the conveying bearing mechanism 112 to move to the slide receiving position P2, so that the conveying bearing mechanism 112 receives the first slide stored in the slide storage unit 18 at the slide receiving position P2. Then, the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move to the slide pushing position P3, so that the first slide on the conveying bearing mechanism 112 is transferred to the detection bearing mechanism 161. Finally, the detection and push piece operation are completed.

[0061] Further referring to Figure 2 , Figure 4 and Figure 6 , the bearing unit 16 in the embodiment further comprises a bearing power mechanism 164, which is connected with the detection bearing mechanism 161 to drive the detection bearing mechanism 161 to move. A sample adding position P4 and a first detection position P5 are arranged along the movement track of the detection bearing mechanism 161. The sample adding unit 12 is used for adding the sample to the first slide at the sample adding position P4. The detection unit 13 is used for detecting the diffusion parameter of the sample on the first slide at the first detection position P5, and generating corresponding detection data.

[0062] Specifically, in order to collect a clear and complete diffusion image of the sample, the detection unit 13 is generally installed above the detection bearing mechanism 161. Therefore, in actual application, the bearing power mechanism 164 first drives the detection bearing mechanism 161 to move to the sample adding position P4, so that the sample adding unit 12 adds the sample to the first slide. Then, the bearing power mechanism 164 drives the detection bearing mechanism 161 to move to the first detection position P5, so that the detection unit 13 detects the sample. This way of arranging the sample adding position P4 and the first detection position P5 separately can avoid the interference between the sample adding unit 14 and the detection unit 13.

[0063] Further refer to Figure 2 and Figure 4 The pushing device 10 in the embodiment further comprises a printing unit 19, and a printing position P6 is further arranged along the movement track of the conveying bearing mechanism 112. The printing unit 19 is used for performing slide printing on the first slide at the printing position P6.

[0064] Specifically, after the conveying bearing mechanism 112 receives the first slide stored in the slide storage unit 13 at the slide receiving position P2, the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move the first slide to the printing position P6, so that the printing unit 19 performs slide printing on the first slide 110.

[0065] Please refer to Figure 12 , Figure 12 is Figure 1 the position schematic diagram of another embodiment of the pushing device 10. In the another embodiment, a second detection position P7 is further arranged along the movement track of the conveying bearing mechanism 112. The detection unit 13 is used for detecting the diffusion parameter of the sample on the slide 110 at the second detection position P7 and generating corresponding detection data. That is, in the another embodiment, after the conveying bearing mechanism 112 receives the slide 110, for example, first receives the slide 110 stored in the slide storage unit 18 at the slide receiving position P2, and after the slide printing is completed at the printing position P6, the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move the slide 110 to the sample adding position P4, so that the sample adding unit 12 adds the sample on the slide 110, and then the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move the slide 110 to the second detection position P7, so that the detection unit 13 detects the sample on the slide 110 at the second detection position P7. After the detection is completed, the conveying driving mechanism 111 drives the conveying bearing mechanism 112 to move the slide 110 to the slide pushing position P1, so that the slide pushing unit 15 completes the slide pushing operation at the slide pushing position P1. In this way, the bearing unit 16 in the above embodiment is not needed, and the receiving of the slide 110, the detection of the sample and the slide pushing operation can be completed directly through the conveying unit 11. The structure of the pushing device 10 and the entire flow action are simplified, the cost is reduced, and the time is saved.

[0066] Please refer to Figure 2 and Figure 13 , Figure 13 is Figure 2The push piece device 10 in the embodiment further comprises a first drying unit 10a, the first drying unit 10a is in communication connection with the processing unit 14, the processing unit 14 is further used for determining a first drying parameter according to the detection data corresponding to the diffusion parameter, and controlling the first drying unit 10a to dry the slide after the push piece is completed, so that the first drying unit 10a can dry the slide according to the first drying parameter corresponding to the diffusion parameter, and the drying effect is improved.

[0067] The processing unit is used for controlling at least one of the air outlet angle, the air outlet speed and the air outlet time of the first drying unit according to the first drying parameter.

[0068] For example, when the viscosity of the sample is low according to the diffusion parameter as described above, in order to avoid blowing away the sample cells on the slide 110, the processing unit 14 can control the first drying unit 10a to blow air to the slide 110 in a direction perpendicular to the slide 110, that is, the air outlet angle between the air outlet direction of the first drying unit 10a and the slide 110 is 90°; when the viscosity of the sample is high according to the diffusion parameter, the processing unit 14 can control the air outlet direction of the first drying unit 10a to be inclined relative to the slide 110, for example, control the included angle between the air outlet direction of the first drying unit 10a and the slide 110 to be 30°, which can reduce the air resistance of the first drying unit 10a when blowing air to the slide 110.

[0069] The first drying unit 10a comprises an air supply part 100a, which dries the slide 120 by blowing air to the slide 110. In the embodiment, the drying unit 13 further comprises a heater 100b, which is used to generate drying heat, and then the air supply part 100a blows air to the heater 100b, so that the air blown to the slide 110 is hot air, and the drying efficiency is improved.

[0070] Further, the drying unit 10a in the embodiment further comprises a support 100c and a drying shell 100d, the heater 100b is arranged in the support 100c, the air supply part 100a is installed on the support 100c, and the drying shell 100d covers the support 100c.

[0071] Please refer to Figure 14 and Figure 15 , Figure 14 is a schematic diagram of the three-dimensional structure of the push piece staining machine 20 provided in the embodiment, Figure 15 is Figure 14A schematic diagram of a perspective view of the dyeing device 21. The slide dyeing machine 20 in the embodiment includes the dyeing device 21 and the slide pushing device 10 in the above embodiment. The processing unit 14 is further configured to determine dyeing parameters according to the detection data corresponding to the diffusion parameters, and control the dyeing device 21 to dye the slide 110 according to the dyeing parameters.

[0072] In actual applications, at least one of the dyeing mode, the dyeing solution concentration, the dyeing time, the dyeing temperature, and the reagent type of the dyeing device 21 can be selected according to actual conditions.

[0073] Optionally, the reagent type includes a dyeing reagent, a buffer reagent, etc., and the dyeing mode includes drop dyeing, dip dyeing, single slide dyeing, and multi-slide dyeing.

[0074] Further, the slide dyeing machine 20 in the embodiment further includes a second drying unit 22. The processing unit 14 is further configured to determine second drying parameters according to the detection information of the sample, and control the second drying unit 22 to dry the slide after dyeing according to the second drying parameters. The second drying parameters can also be at least one of the air outlet angle, the air outlet speed, and the air outlet time, which can be selected according to actual conditions in actual applications.

[0075] Please refer to Figure 16 , Figure 16 The control method of the slide pushing device 10 provided in the application includes the following steps.

[0076] S110: controlling the sample adding unit to add the sample to the slide;

[0077] S120: controlling the detection unit to detect the diffusion parameters of the sample on the slide and generate corresponding detection data;

[0078] S130: determining the slide pushing parameters according to the detection data;

[0079] S140: controlling the slide pushing unit to apply the sample to the slide at the slide pushing position according to the slide pushing parameters.

[0080] It can be understood that the specific principles of the above steps can be referred to the related descriptions in the above embodiments of the slide pushing device 10, which will not be described here again.

[0081] Different from the prior art, the slide pushing device provided by the embodiments of the present application comprises: a conveying unit comprising a conveying driving mechanism and a conveying bearing mechanism, the conveying bearing mechanism is used for bearing a slide, the conveying driving mechanism is connected with the conveying bearing mechanism to drive the conveying bearing mechanism to move, and a slide pushing position is arranged along the movement track of the conveying bearing mechanism; a sample adding unit used for adding a sample to the slide; a detection unit used for detecting a diffusion parameter of the sample on the slide and generating corresponding detection data; a processing unit in communication connection with the detection unit, the processing unit is used for receiving the detection data of the detection unit and determining a slide pushing parameter according to the detection data; and a slide pushing unit used for coating the sample on the slide according to the slide pushing parameter at the slide pushing position. The diffusion parameter reflects the viscosity of the sample, so that the slide pushing unit can perform a slide pushing operation according to the slide pushing parameter corresponding to the viscosity of the sample, compared with the prior art, the slide pushing requirement corresponding to the viscosity of the sample is met, and the high quality standard of the smear formed by coating the sample on the slide is ensured.

[0082] The above only describes some embodiments of the present application, and does not limit the protection scope of the present application, and any equivalent device or equivalent process transformation using the content of the specification and drawings of the present application, or direct or indirect application in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A pusher device, characterized in that, The pusher device includes: The conveying unit includes a conveying drive mechanism and a conveying support mechanism. The conveying support mechanism is used to support glass slides. The conveying drive mechanism is connected to the conveying support mechanism to drive the conveying support mechanism to move. A slide push position is provided along the movement trajectory of the conveying support mechanism. A sample application unit is used to add samples onto the glass slide; The detection unit is used to detect the diffusion parameters of the sample on the glass slide and generate corresponding detection data; A processing unit is communicatively connected to the detection unit. The processing unit is used to receive the detection data from the detection unit and determine the pushing parameters based on the detection data. A slide-pushing unit is used to coat the sample onto the glass slide at the slide-pushing position according to the slide-pushing parameters; The slide pushing device further includes a first drying unit that is communicatively connected to the processing unit. The processing unit is further configured to determine a first drying parameter based on the detection data corresponding to the diffusion parameter, and to control the first drying unit to dry the slide after the slide pushing is completed based on the first drying parameter. The conveying and carrying mechanism is used to carry the first glass slide, the sample application unit is used to add the sample to the first glass slide, the detection unit is used to detect the diffusion parameters of the sample on the first glass slide and generate corresponding detection numbers, the conveying and carrying mechanism is also used to carry the second glass slide, the sample application unit is also used to add the sample to the second glass slide, and the slide pushing unit is used to coat the sample on the second glass slide at the slide pushing position according to the slide pushing parameters.

2. The pusher device according to claim 1, characterized in that, The processing unit is used to determine the viscosity of the sample according to the formula Y = kX, and to determine the pusher parameters according to the viscosity of the sample, where Y represents the viscosity of the sample, k represents a coefficient, and X represents the pusher parameters.

3. The pusher device according to claim 1, characterized in that, The processing unit is used to control at least one of the air outlet angle, air outlet speed, and air outlet time of the first drying unit according to the first drying parameters.

4. The pusher device according to claim 1, characterized in that, The slide pushing device further includes a carrier unit, which includes a detection carrier mechanism. The conveying unit further includes a first push driving mechanism and a first push member. The first push driving mechanism is connected to the first push member to drive the first push member to push the first glass slide from the conveying carrier mechanism to the detection carrier mechanism.

5. The pusher device according to claim 4, characterized in that, The carrier unit further includes a second push driving mechanism and a second pusher. The second push driving mechanism is connected to the second pusher to drive the second pusher to push the first glass slide after the detection is completed from the detection carrier mechanism to the transport carrier mechanism. The slide pushing unit is used to coat the sample onto the first glass slide at the slide pushing position according to the slide pushing parameters.

6. The pusher device according to claim 1, characterized in that, The slide pushing device also includes a recycling unit, which is used to recycle the first glass slide after the testing is completed.

7. A slide-staining machine, characterized in that, The slide-pushing and staining machine includes a staining device and a slide-pushing device according to any one of claims 1 to 6. The processing unit is further configured to determine staining parameters based on the detection data corresponding to the diffusion parameters, and to control the staining device to stain the glass slide according to the staining parameters.

8. The slide-pushing staining machine according to claim 7, characterized in that, The processing unit is used to control at least one of the following in the dyeing device according to the dyeing parameters: dyeing mode, dye concentration, dyeing time, dyeing temperature, and reagent type. And / or the slide staining machine further includes a second drying unit, the processing unit is further configured to determine the second drying parameters according to the detection data corresponding to the diffusion parameters, and control the second drying unit to dry the stained slides according to the second drying parameters.

9. A control method for the pusher device according to any one of claims 1 to 6, characterized in that, The control method includes: controlling the sample application unit to add the sample onto the glass slide; The control detection unit detects the diffusion parameters of the sample on the glass slide and generates corresponding detection data; Determine the pusher parameters based on the test data; The pusher unit is controlled according to the pusher parameters to apply the sample onto the glass slide at the pusher position.

Citation Information

Patent Citations

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