An atomizer discrete atomization system and control method

Abstract

This invention provides a discrete nebulization system and control method for an nebulizer, including a medicine bottle mounting base, an nebulization unit, and a control system. The key feature is that the medicine bottle mounting base has at least one medicine bottle inlet at its top, and the bottom of the mounting base is connected to the nebulization unit. The nebulization unit includes a housing, an nebulization assembly, and a nozzle. A medicine channel is provided in the medicine bottle mounting base, and the medicine bottle inlet communicates with the nebulization unit through the medicine channel. The control system includes a metered-dose controller and a metered-dose control block. The nebulization assembly and the metered-dose controller are connected to a power socket on the medicine bottle mounting base via a circuit. The metered-dose control block is located on the medicine channel, and the metered-dose controller controls the metered-dose control block to close or open the medicine channel, achieving discrete nebulization. This system achieves consistently high-quality nebulization and effective drug delivery, avoids the failure of un-nebulized drugs while waiting to be nebulized, and mitigates the adverse effects of transient voltage pulses.

Description

Technical Field

[0001] This invention belongs to the field of medical nebulization technology, specifically a discrete nebulization system and control method for a nebulizer. Background Technology

[0002] With the development of medical technology, nebulization technology is no longer just an important technique in the treatment of respiratory diseases, but is also being widely used in vaccination, health care, and the treatment of various non-respiratory diseases such as diabetes, heart disease, cancer, and tumors, with broad market prospects.

[0003] The increasingly widespread application scenarios and the emergence of new nebulized drugs, including various vaccines, have placed higher demands on nebulization technology. The core technical challenge lies in ensuring consistently high-quality nebulization and effective drug delivery. This requires that various nebulization technical indicators, especially the particle size distribution, remain consistent from the start to the end of nebulization. Simultaneously, the effectiveness of the nebulized drug must not be affected by environmental factors during nebulization, such as temperature changes or vibrations of the nebulizer plate.

[0004] Traditional nebulizers operate on a continuous nebulization model after a single dose. Prolonged operation of the nebulization components can lead to a decline in nebulization quality due to factors such as nebulizer plate overheating and clogging, making it impossible to maintain consistently high-quality nebulization over the long term. Furthermore, the long nebulization time, temperature fluctuations in the nebulizer plate, and continuous vibrations can adversely affect medications that haven't yet been nebulized, potentially causing them to become ineffective. For example, the shear force generated by the nebulization unit may damage un-nebulized lipid nanoparticles (LNPs) used for vaccine delivery. Moreover, existing nebulizers often generate transient voltage pulses upon startup, which can also affect the initial nebulization effect, especially during the nebulization of micro-dose medications such as vaccines (which typically lasts from ten to several tens of seconds). These pulse changes have a particularly significant impact on nebulization quality and delivery effectiveness.

[0005] Therefore, how to improve existing nebulization technology to achieve consistently high-quality nebulization and effective drug delivery, while avoiding the failure of unnebulized drugs during the waiting period and the adverse effects of transient voltage pulses, has become an urgent and important technical issue for the further development of nebulization technology and its entry into a wider market. Summary of the Invention

[0006] This invention addresses the problems and shortcomings of existing technologies by providing a discrete nebulizer system and a discrete nebulizer control method. This system achieves consistently high-quality nebulization and effective drug delivery, while preventing unnebulized drugs from failing during the nebulization process and avoiding the adverse effects of transient voltage pulses.

[0007] The objective of this invention is achieved through the following technical solution:

[0008] A discrete nebulizer system includes a medicine bottle mounting base, a nebulizing unit, and a control system. The medicine bottle mounting base has at least one medicine bottle inlet at its top, the bottom of the mounting base is connected to the nebulizing unit, and a power outlet is located on one side of the mounting base. The nebulizing unit includes a housing, a nebulizing assembly, and a nozzle. A medicine channel is provided in the medicine bottle mounting base, and the medicine bottle inlet communicates with the nebulizing unit through the medicine channel. The control system includes a metered-dose controller and a metered-dose control block. The nebulizing assembly and the metered-dose controller are connected to the power outlet via a circuit. The metered-dose control block is located on the medicine channel, and the metered-dose controller controls the metered-dose control block to close or open the medicine channel, thereby achieving discrete nebulization by the nebulizing unit.

[0009] Improvements to the above technical solution: A piercing device is provided inside the medicine bottle inlet. When the medicine bottle is inserted into the inlet, the piercing device will pierce the bottle cap. The piercing device is provided with a vent and a liquid inlet. An air inlet channel is provided in the medicine bottle mounting base. One end of the air inlet channel is located on the top surface of the medicine bottle mounting base, and the other end of the air inlet channel is connected to the vent on the piercing device. The air inlet channel, together with external air, is used to maintain the air pressure balance inside and outside the medicine bottle, ensuring smooth flow of the medicine.

[0010] Further improvements to the above technical solution: a filter cotton is provided on the air inlet and outlet of the air inlet channel, and a filter cotton pressure plate is provided on the top surface of the medicine bottle mounting base aligned with the air inlet and outlet.

[0011] Further improvements to the above technical solution: The housing of the atomizing unit includes an upper housing and a lower housing. The upper housing is integrally connected to the bottom of the medicine bottle mounting base. The lower housing is detachably connected to the upper housing. The atomizing component includes an atomizing plate, which is disposed between the lower housing and the upper housing. The mist outlet is disposed at the bottom of the lower housing.

[0012] A control method for the above-mentioned discrete atomization system of an atomizer, characterized in that the control method includes the following steps:

[0013] Step 1: Insert the medicine bottle into the medicine bottle socket of the medicine bottle mounting base so that the medicine in the medicine bottle enters the atomizing unit through the medicine channel for atomization;

[0014] Step 2: The quantitative drug delivery controller controls the displacement of the quantitative drug delivery control block, intermittently closing and opening the drug channel to supply the drug to the nebulization unit in stages, and starts the nebulization assembly to achieve discrete nebulization.

[0015] Improvement to the above technical solution: In step 2, the quantitative drug delivery controller first calculates the dosage, number of nebulizations and interval time for each administration, and then starts the nebulization component to perform discrete nebulization until the amount of nebulized drug required for this treatment is nebulized.

[0016] Further improvements to the above technical solution: In step 2, the quantitative drug delivery controller calculates the dosage, number of nebulizations, and interval time for each administration based on data such as drug stability, nebulizer output, and the duration of a single user's inhalation.

[0017] Further improvements to the above technical solution: The medicine bottle mounting base has at least three medicine bottle inlets for accommodating at least two types of normal nebulization therapy drugs and nebulization component maintenance drugs. The nebulization component maintenance drugs include cleaning fluid and nebulization therapy drug filling fluid. The nebulization therapy drug filling fluid is used to replenish the nebulization therapy drugs to complete one nebulization when the remaining amount of nebulization therapy drugs is insufficient to complete one nebulization.

[0018] Further improvements to the above technical solution: In the case of instantaneous voltage pulses affecting atomization quality and delivery effect during startup, the first drug supply to the atomization component is only the filling liquid for atomized therapeutic drugs to avoid the influence of instantaneous voltage pulses.

[0019] Further improvements to the above technical solution: In scenarios where transient voltage pulses in the atomizing component affect atomization quality and delivery effect, to avoid transient voltage pulses caused by intervals in single discrete atomization, an appropriate amount of atomized therapeutic drug filling fluid is added to the atomizing component between two discrete atomizations to maintain the operation of the atomizing component and avoid transient voltage pulses caused by the intervals in atomization.

[0020] Further improvements to the above technical solution: For a single discrete nebulization, the quantitative drug delivery controller detects the status of the nebulization component and determines the time interval between two single discrete nebulizations to allow the nebulization component to return to its optimal working state.

[0021] Further improvements to the above technical solution: If an abnormality is detected in the nebulizer component, an active intervention operation is initiated, that is, cleaning fluid or nebulized drug filling fluid is supplied to the nebulizer component, and the nebulizer component is activated to complete the cleaning or nebulization operation; after the nebulizer component is in normal condition, a new single discrete nebulization continues.

[0022] Further improvements to the above technical solution: The nebulization system is equipped with an audio-visual indicator device to prompt the user to inhale when the drug is nebulized; and to prompt the user not to inhale when the nebulization component is under maintenance or during a single discrete nebulization interval.

[0023] Further improvements to the above technical solution: The quantitative drug delivery controller monitors the status of the nebulizer unit in real time and determines the time interval between two discrete nebulizations to allow the nebulizer component to return to its optimal working state; if the nebulizer component is found to be blocked or the temperature is too high and exceeds a given threshold, or if the waiting time exceeds a given threshold, an active intervention operation is initiated.

[0024] Further improvements to the above technical solution: The quantitative drug delivery controller supports user-configured multi-drug cross-nebulization, that is, multiple drugs can be cross-nebulized in a single or multiple optimal dose to achieve micro-discrete cross-nebulization; in this case, before performing a single discrete nebulization operation for another nebulized drug, the quantitative drug delivery controller will control the quantitative drug delivery control block, drug channel and nebulization unit to perform a nebulization unit cleaning operation; the nebulized drug switching and nebulization unit cleaning operation are fully automated and require no manual intervention.

[0025] The advantages and positive effects of this invention are:

[0026] 1. This invention guarantees consistently high-quality nebulization and effective drug delivery, and the various quality parameters of nebulization will not decrease due to long-term operation of the nebulization component;

[0027] 2. This invention avoids the impact of the nebulization process on drug effectiveness, ensuring that unnebulized drugs remain effective.

[0028] 3. This invention avoids the impact of instantaneous voltage pulses during the startup of the atomizing device on atomization quality and delivery effect;

[0029] 4. This invention supports multiple drug nebulization scenarios, drug switching, nebulizer cleaning, and is fully automated without manual intervention;

[0030] 5. This invention reduces the dependence of atomization effect on atomization components, and can effectively improve atomization quality and drug delivery effect when using the same atomization components;

[0031] 6. This invention truly achieves on-demand nebulization, minimizing waste of medication in cases of abnormal nebulization termination due to various reasons. Attached Figure Description

[0032] Figure 1 This is a perspective view of a discrete atomization system for an atomizer according to the present invention;

[0033] Figure 2 This is a top view of a discrete atomization system for an atomizer according to the present invention;

[0034] Figure 3 yes Figure 2 Sectional view along axis AA;

[0035] Figure 4 This is a schematic diagram of a discrete atomization system for an atomizer and a medicine bottle according to the present invention;

[0036] Figure 5 This is a flowchart of the discrete atomization system of the atomizer according to the present invention;

[0037] Figure 6 This is a flowchart of a single discrete atomization process of a discrete atomization system for an atomizer according to the present invention.

[0038] Figure 7 This is a flowchart illustrating the instantaneous pulse problem handling process of a discrete atomization system for an atomizer according to the present invention.

[0039] The numbers in the diagram are as follows: 1-Drug bottle, 2-Main body of quantitative drug delivery controller, 2.1-Drug bottle socket, 3-Power / control socket, 4-PIN needle, 5-Atomizing unit, 6-Mist nozzle, 7-Filter cotton pressure plate, 8-Filter cotton, 9-Air inlet channel, 10-Piercing device, 10.1-Ventilation port, 10.2-Liquid inlet, 11-Quantitative drug delivery controller, 12-Quantitative drug delivery control block, 13-Drug channel. Implementation

[0040] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments:

[0041] See Figures 1-4 This invention discloses an embodiment of a discrete nebulizer system, comprising a medicine bottle mounting base 2, an nebulizing unit 5, and a control system. The medicine bottle mounting base 2 has at least one medicine bottle inlet 2.1 at its top, and its bottom is connected to the nebulizing unit 5. A power socket 3 is located on one side of the medicine bottle mounting base 2, and a PIN pin 4 is installed within the power socket 3. The nebulizing unit 5 includes a housing, an nebulizing assembly, and a mist outlet 6. A medicine channel 13 is provided in the medicine bottle mounting base 2, and the medicine bottle inlet 2.1 communicates with the nebulizing unit 5 through the medicine channel 13. The control system includes a metering controller 11 and a metering control block 12. The nebulizing assembly and the metering controller 11 are connected to the power socket 3 (PIN pin 4) via a circuit. The metering control block 12 is located on the medicine channel 13, and the metering controller 11 controls the metering control block 12 to close or open the medicine channel 13, thereby achieving discrete nebulization of the nebulizing unit 5.

[0042] The discrete nebulization working mode proposed in this invention differs from the traditional nebulizer's continuous nebulization mode after a single dose. This invention proposes a novel mode of continuous micro-volume drug nebulization, where medication is supplied and nebulized in stages based on the effectiveness of the nebulized drug and the working status of the nebulizer component. This divides the traditionally long and complete nebulization treatment process into several relatively independent small or micro-volume nebulization processes. Unnecessary medication remains in the medication bottle 1 instead of in the nebulizer component's medicine cup during treatment. This effectively avoids the influence of the nebulizer component on the unnebulized medication. Furthermore, the micro-volume drug nebulization process itself has minimal impact on the nebulizer unit 5, preventing overheating and degradation of nebulization quality as is common in current long-duration continuous nebulization processes. Moreover, the introduction of appropriate time intervals or nebulizer unit maintenance operations between each micro-volume nebulization further ensures that the nebulizer component remains in optimal condition, thus guaranteeing consistent nebulization quality from multiple aspects, offering significant advantages over existing nebulization technologies. Because from a microscopic spatiotemporal perspective, each of the above-mentioned micro-drug nebulizations is relatively independent and discrete, we call it discrete nebulization.

[0043] In practice, there can be one or more medication bottles 1. This embodiment provides an example of a discrete nebulizer system supporting up to three medication bottles. These three medication bottle slots 2.1 can be used to hold three different types of medications, such as nebulized therapeutic drugs, nebulized therapeutic drug refill fluid, or other liquids. The nebulized therapeutic drug refill fluid is used to replenish the nebulized therapeutic drug when the remaining amount is insufficient to complete one nebulization cycle. In scenarios where nebulized therapeutic drug refill fluid or other liquids are not needed, all three medication bottle slots 2.1 can be used to hold nebulized therapeutic drugs. Furthermore, different types of nebulized therapeutic drugs can be held in different medication bottle slots 2.1 to achieve cross-nebulization or sequential nebulization of different drugs. This effectively improves the efficiency of the nebulizer system and its support for different nebulizer treatment scenarios.

[0044] Furthermore, a piercing device 10 is provided inside the medicine bottle inlet 2.1. The piercing device 10 includes a piercing blade and a piercing blade mounting base, with the piercing blade fixed to the mounting base. A vent 10.1 and a liquid inlet 10.2 are provided on the piercing device. When the medicine bottle 1 is inserted into the medicine bottle inlet 2.1, the piercing blade in the piercing device will pierce the cap of the medicine bottle 1. Thus, under the influence of gravity, the medicine will flow into the medicine channel 13 through the liquid inlet 10.2.

[0045] An air inlet channel 9 is provided in the medicine bottle mounting base 2. The air inlet port at one end of the air inlet channel 9 is located on the top surface of the medicine bottle mounting base 2. The other end of the air inlet channel 9 is connected to the vent 10.1 on the puncture device 10. The air inlet channel 9 is connected to the outside air to maintain the air pressure balance inside and outside the medicine bottle 1 and ensure the smooth flow of medicine.

[0046] Furthermore, to ensure that the liquid medicine in the medicine bottle 1 is clean and uncontaminated, a filter cotton 8 is installed on the air inlet and outlet of the air inlet channel 9. The filter cotton 8 is used to filter the incoming and outgoing air, and a filter cotton pressure plate 7 is installed on the top surface of the medicine bottle mounting base 2, aligned with the air inlet and outlet.

[0047] Furthermore, the housing of the aforementioned atomizing unit 5 includes an upper housing and a lower housing. The upper housing is integrally connected to the bottom of the medicine bottle mounting base 2, and the lower housing is detachably connected to the upper housing. The atomizing assembly includes an atomizing plate disposed between the lower housing and the upper housing, and the mist outlet 6 is disposed at the bottom of the lower housing. Preferably, the atomizing plate is a micro-mesh atomizing plate.

[0048] The core component of this invention is the quantitative drug delivery controller 11, which controls the quantitative drug delivery control block 12 connected to the drug delivery channel 13 of the corresponding drug bottle 1 to achieve precise drug delivery to the nebulization unit 5. Depending on the drug solution provided, it further controls the nebulization unit 5 to perform operations such as drug nebulization or cleaning. Furthermore, it makes various adjustments to the control based on feedback from various state parameters of the nebulization unit 5 (e.g., temperature, operating frequency).

[0049] The nebulizer discrete atomization control method proposed in this invention can be implemented on the quantitative drug delivery controller 11, on external intelligent hardware and software (such as an external controller, user intelligent device, etc.), or in combination of both. When external intelligent hardware and software are involved in the control, the external intelligent hardware and software can be connected to the quantitative drug delivery controller 11 for control via the PIN pin 4 on the power socket 3, or it can be connected to the quantitative drug delivery controller 11 via any existing wireless technology to complete the relevant control operations.

[0050] See Figures 1-7 An embodiment of the control method for the above-mentioned discrete atomization system of the atomizer according to the present invention includes the following steps:

[0051] Step 1: Insert the medicine bottle 1 into the medicine bottle inlet 2.1 of the medicine bottle mounting base 1, so that the medicine in the medicine bottle 1 enters the atomizing unit 5 through the medicine channel 13 for atomization;

[0052] Step 2: The quantitative drug delivery controller 11 controls the displacement of the quantitative drug delivery control block 12, intermittently closing and opening the drug channel, supplying the drug to the nebulization unit 5 in batches, and starting the nebulization assembly to achieve discrete nebulization.

[0053] Furthermore, in step 2 above, the quantitative drug delivery controller 11 first calculates the dosage, number of nebulizations and interval time for each administration, and then starts the nebulization component to perform discrete nebulization until the amount of nebulized drug required for this treatment is nebulized.

[0054] Furthermore, in step 2 above, the quantitative drug delivery controller calculates the dosage, number of nebulizations, and interval time for each administration based on data such as drug stability, nebulizer output, and the duration of a single user's inhalation.

[0055] Preferably, the above-mentioned liquid bottle mounting base 2 has at least three liquid bottle inlets 2.1 for accommodating at least two kinds of normal nebulization therapy drugs and nebulization component maintenance drugs. The nebulization component maintenance drugs include cleaning fluid and nebulization therapy drug filling fluid. The nebulization therapy drug filling fluid is used to replenish the nebulization therapy drugs to complete one nebulization when the remaining amount of nebulization therapy drugs is insufficient to complete one nebulization.

[0056] Preferably, in scenarios where the instantaneous voltage pulse at startup affects the atomization quality and delivery effect, the first drug supply to the atomization component is only the atomization therapy drug filling liquid to avoid the influence of the instantaneous voltage pulse.

[0057] Preferably, in scenarios where transient voltage pulses in the atomizing component affect the atomization quality and delivery effect, to avoid transient voltage pulses caused by intervals in single discrete atomizations, an appropriate amount of atomized therapeutic drug filling fluid is added to the atomizing component between two discrete atomizations to maintain the operation of the atomizing component and avoid transient voltage pulses caused by the intervals in atomization.

[0058] Preferably, during a single discrete nebulization, the quantitative drug delivery controller detects the status of the nebulization component and determines the time interval between two single discrete nebulizations to allow the nebulization component to return to its optimal working state.

[0059] Preferably, if an abnormality is detected in the atomizing component, an active intervention operation is initiated, namely, a cleaning fluid is supplied to the atomizing component, and the atomizing component is started to complete the cleaning; after the atomizing component is in normal condition, a new single discrete atomization continues.

[0060] Preferably, the nebulization system is equipped with an audio-visual indicator to prompt the user to inhale when the drug is nebulized, and to prompt the user not to inhale when the nebulization component is under maintenance or during a single discrete nebulization interval.

[0061] Preferably, the quantitative drug delivery controller monitors the status of the nebulizer unit in real time and determines the time interval between two discrete nebulizations to allow the nebulizer component to return to its optimal working state; if the nebulizer component is found to be blocked or the temperature is too high and exceeds a given threshold, or if the time interval to wait exceeds a given threshold, an active intervention operation is initiated.

[0062] Preferably, the quantitative drug delivery controller supports user-configured multi-drug cross-nebulization, that is, multiple drugs can be cross-nebulized in a single or multiple optimal dose to achieve micro-discrete cross-nebulization. In this case, before performing a single discrete nebulization operation for another nebulized drug, the quantitative drug delivery controller 11 will control the quantitative drug delivery control block 12, the drug channel 13 and the nebulization unit 5 to perform a nebulization unit cleaning operation. The nebulized drug switching and nebulization unit cleaning operation are fully automated and require no manual intervention.

[0063] Furthermore, this system is equipped with an audio-visual indicator to prompt the user to inhale the medication when it is nebulized. When maintenance is performed on the nebulization unit 5, i.e., when the metered drug delivery controller 11 supplies cleaning fluid to the nebulization unit 5 and starts the nebulization assembly to complete the cleaning operation, the user is prompted that inhalation is not necessary.

[0064] Furthermore, the system continuously records the amount of medication already nebulized during the current treatment. Based on the difference between this amount and the total amount required for a single treatment, it calculates the amount of medication yet to be nebulized and divides this by the optimal dosage to estimate the number of discrete nebulization sessions needed in the future. This information is then displayed to the user via an audio-visual indicator, keeping them informed. Simultaneously, within the maximum allowed time frame for a single nebulization treatment, the system allows the user to pause nebulization for a short rest, improving user comfort and ensuring the quality of the medication remains unaffected.

[0065] For specific implementation, please refer to Figure 5 This invention provides a control method and workflow for a discrete nebulizer system. After powering on, the system first reads all medication information inserted into the medication bottle port 2.1, as well as the drug's parameter information, such as drug stability. If drug stability is related to temperature and vibration frequency, the system also needs to obtain the relevant correlation calculation formula and the dosage required for one nebulization treatment (or vaccination). Note: Drug stability refers to how long the drug's effectiveness can be maintained under the current nebulizer component parameters (temperature, vibration frequency, etc.). This medication information can be automatically read from the ID carried by the medication bottle 1 or input by the user. Then, the system obtains various operating parameter information of the nebulizer unit 5, including at least: whether there is an instantaneous start-up pulse problem, if so, its duration, the amount of mist output from the nebulizer unit, the current temperature, the operating frequency, and whether the nebulizer plate is blocked. If the nebulizer unit 5 does not have an instantaneous start-up pulse problem, a single discrete nebulization operation can be directly initiated. The steps for a single discrete nebulization operation are as follows: Figure 6 As shown, the process includes the nebulization system calculating the optimal dosage for each administration, supplying medication to the nebulization component according to the calculated optimal dosage, and then activating the nebulization unit 5 to nebulize the supplied medication. The optimal dosage calculation can be based on drug stability, nebulization component output volume, and single user inhalation time data. Drug stability refers to how long the drug's effectiveness can be maintained under the current nebulization component parameters (temperature, vibration frequency, etc.). Nebulization component output volume data refers to the amount of medication that the nebulization component can nebulize per second during operation. Single user inhalation time data can be directly configured data or detected by the system. For example, the average of multiple inhalation times by the user. Below is an example of optimal dosage calculation: assuming the drug stability is 3 seconds and the nebulization component output volume is 0.01 mL / s, then the current optimal dosage is 0.01 mL / s × 3 seconds = 0.03 mL. This ensures that the medication is completely nebulized by the nebulization unit before it becomes ineffective, thus avoiding drug failure caused by the nebulization process. The nebulization system can fine-tune the optimal dosage within a reasonable range for each treatment based on specific circumstances. For example, if a total of 0.05 mL of medication is needed for this nebulization treatment, and 0.03 mL has already been administered in the first treatment, then although the optimal dosage for the second treatment might still be 0.03 mL according to the above calculation, the actual dosage needed is 0.05 - 0.03 = 0.02 mL. Another example: if the drug stability is currently 6 seconds and the nebulizer output is 0.01 mL / s, but the user has configured their preferred longest inhalation time to be 4 seconds, then the current optimal dosage is the minimum value of 0.01 mL / s × (6 seconds, 4 seconds) = 0.04 mL. Drug stability and nebulizer output may change due to variations in environmental parameters (e.g., nebulizer temperature, vibration frequency, current voltage, and current). In such cases, the system monitors these parameters in real time, calculates drug stability and nebulizer output based on relevant formulas, and further calculates the optimal dosage for each treatment. To reduce unnecessary system latency, the aforementioned parameter detection and calculation processes can be performed in parallel with the previous single discrete atomization. Regardless of the specific optimizations implemented, they all fall within the scope of this invention.

[0066] After a single discrete nebulization operation is completed, the system checks whether the nebulization treatment has ended, i.e., whether the required dosage of medication for this nebulization treatment (or vaccination) has been nebulized. If so, a nebulization treatment termination process is initiated, i.e., a nebulization unit cleaning operation. Cleaning solution is injected from the cleaning solution bottle into nebulization unit 5, and the system controls it to complete the cleaning action. Afterward, nebulization unit 5 is in a completely clean and ready state, awaiting the command to start the next nebulization (or vaccination) treatment. If the current nebulization treatment has not ended, before restarting a single discrete nebulization operation, the current working status of nebulization unit 5 is checked, and the time interval between two single discrete nebulization operations is determined to allow the nebulization component to return to its optimal working state. If the nebulizer plate is found to be clogged or the temperature is too high and exceeds a given threshold, or if the waiting time exceeds a given threshold, an active intervention operation is initiated, i.e., cleaning solution is supplied to the nebulization component, and the nebulization component is activated to complete the cleaning operation. Once the nebulizer assembly is functioning normally, a new round of discrete nebulization operation continues, namely: optimal dosage calculation → drug delivery to the nebulizer assembly according to the optimal dosage → nebulization.

[0067] If the atomizing unit 5 has a momentary start-up pulse problem, in order to avoid the momentary voltage pulse during the start-up of the atomizing device affecting the atomization quality and delivery effect, Figure 7 The workflow shown is initiated. The quantitative drug delivery controller 11 initially supplies the nebulizer unit 5 with a specific effective liquid, such as a nebulized therapeutic drug filler solution, and activates the nebulizer unit to avoid the transient voltage pulse period. The amount of liquid supplied is calculated based on the mist output of the nebulizer component and the duration of the transient pulse. For example, if the mist output of the nebulizer component is 0.01 mL / s and the maximum duration of the transient pulse is 3 seconds, then the filler solution supply is 0.01 mL / s × 3 seconds = 0.03 mL. After avoiding the transient voltage pulse period, the discrete nebulization workflow is initiated for drug nebulization. In scenarios where transient voltage pulses in the nebulizer assembly affect nebulization quality and delivery effectiveness, to avoid transient voltage pulses caused by single discrete nebulization (i.e., optimal dosage calculation → drug delivery to the nebulizer assembly according to the optimal dosage → nebulization) or intervals between nebulizer unit maintenance operations, the nebulization system replenishes the nebulizer assembly with an appropriate amount of liquid, such as nebulized therapeutic drug filler fluid, between two discrete nebulizations or nebulizer unit maintenance operations. This maintains the operation of the nebulizer assembly and avoids transient voltage pulses caused by the interval between nebulization or cleaning. The amount of the maintenance fluid is determined based on the operation interval duration and the amount of mist output from the nebulizer unit within that interval. This ensures that the maintenance fluid maintains the nebulizer unit in its optimal operating state while ensuring that all maintenance fluid is nebulized within the interval to prevent it from affecting subsequent drug nebulization.

[0068] Of course, the above description is not intended to limit the invention, and the invention is not limited to the examples given above. Any changes, modifications, additions or substitutions made by those skilled in the art within the scope of the invention should also be within the protection scope of the invention.

Claims

1. A discrete atomization system for an atomizer, comprising a medicine bottle mounting base, an atomization unit, and a control system, characterized in that, The top of the liquid bottle mounting base has at least one liquid bottle inlet, the bottom of the mounting base is connected to the nebulizing unit, and a power outlet is provided on one side of the mounting base. The nebulizing unit includes a housing, a nebulizing assembly, and a mist outlet. A liquid channel is provided in the liquid bottle mounting base, and the liquid bottle inlet communicates with the nebulizing unit through the liquid channel. The control system includes a metered-dose controller and a metered-dose control block. The nebulizing assembly and the metered-dose controller are connected to the power outlet via a circuit. The metered-dose control block is located on the liquid channel, and the metered-dose controller controls the metered-dose control block to close or open the liquid channel, thereby achieving discrete nebulization by the nebulizing unit. The liquid bottle... The mounting base has at least three liquid bottle inlets for holding at least two types of normal nebulized therapy medications and nebulizer component maintenance medications. The nebulizer component maintenance medications include cleaning fluid and nebulized therapy medication refill fluid. The nebulized therapy medication refill fluid is used to replenish the nebulized therapy medication to complete one nebulization when the remaining amount of nebulized therapy medication is insufficient. In scenarios where transient voltage pulses at startup affect nebulization quality and delivery effect, the first medication supply to the nebulizer component is only nebulized therapy medication refill fluid to avoid the influence of transient voltage pulses. To avoid transient voltage pulses caused by intervals between discrete nebulizations, an appropriate amount of nebulized therapy medication refill fluid is added to the nebulizer component between two discrete nebulizations to maintain the operation of the nebulizer component.

2. The discrete atomization system for an atomizer according to claim 1, characterized in that, A piercing device is installed inside the medicine bottle inlet. When the medicine bottle is inserted into the inlet, the piercing device will pierce the bottle cap. The piercing device is equipped with a vent and a liquid inlet. An air inlet channel is provided in the medicine bottle mounting base. One end of the air inlet channel is located on the top surface of the medicine bottle mounting base, and the other end of the air inlet channel is connected to the air outlet on the piercing device. The air inlet channel connects with the outside air to maintain the air pressure balance inside and outside the medicine bottle, ensuring smooth flow of the medicine.

3. The discrete atomization system for an atomizer according to claim 2, characterized in that, A filter cotton is installed at the air inlet and outlet of the air inlet channel, and a filter cotton pressure plate is installed on the top surface of the medicine bottle mounting base, aligned with the air inlet and outlet.

4. The discrete atomization system for an atomizer according to any one of claims 1-3, characterized in that, The housing of the atomizing unit includes an upper housing and a lower housing. The upper housing is integrally connected to the bottom of the medicine bottle mounting base. The lower housing is detachably connected to the upper housing. The atomizing component includes an atomizing plate, which is disposed between the lower housing and the upper housing. The mist outlet is disposed at the bottom of the lower housing.

5. The discrete atomization system for an atomizer according to any one of claims 1-3, characterized in that, The atomizer discrete atomization system is configured to include the following operational steps: Step 1: Insert the medicine bottle into the medicine bottle socket of the medicine bottle mounting base so that the medicine in the medicine bottle enters the atomizing unit through the medicine channel for atomization; Step 2: The quantitative drug delivery controller controls the displacement of the quantitative drug delivery control block, intermittently closing and opening the drug channel to supply the drug to the nebulization unit in stages, and starts the nebulization assembly to achieve discrete nebulization.

6. The discrete atomization system for an atomizer according to claim 5, characterized in that, In step 2, the quantitative drug delivery controller first calculates the dosage, number of nebulizations and interval time for each administration, and then starts the nebulization component to perform discrete nebulization until the amount of nebulized drug required for this treatment is nebulized.

7. The discrete atomization system for an atomizer according to claim 6, characterized in that, In step 2, the quantitative drug delivery controller calculates the dosage, number of nebulizations, and interval time for each administration based on data such as drug stability, nebulizer output, and the duration of a single user's inhalation.

8. The discrete atomization system for an atomizer according to claim 6 or 7, characterized in that, In a single discrete nebulization, the quantitative drug delivery controller detects the status of the nebulization component and determines the time interval between two single discrete nebulizations to allow the nebulization component to return to its optimal working state.

9. The discrete atomization system for an atomizer according to claim 6 or 7, characterized in that, If an abnormality is detected in the nebulizer component, an active intervention operation is initiated, which involves supplying cleaning fluid or nebulized medication filling fluid to the nebulizer component and activating the nebulizer component to complete the cleaning or nebulization operation; once the nebulizer component is in normal condition, a new single discrete nebulization session continues.

10. The discrete atomization system for an atomizer according to claim 6 or 7, characterized in that, The nebulization system is equipped with an audio-visual indicator to prompt the user to inhale when the medication is being nebulized, and to prompt the user not to inhale when the nebulization components are under maintenance or when there is a single discrete nebulization interval.

11. The discrete atomization system for an atomizer according to claim 6 or 7, characterized in that, The quantitative drug delivery controller monitors the status of the nebulizer unit in real time and determines the time interval between two discrete nebulizations to allow the nebulizer component to return to its optimal working state. If the nebulizer component is found to be blocked or the temperature is too high and exceeds a given threshold, or if the waiting time exceeds a given threshold, an active intervention operation is initiated.

12. The discrete atomization system for an atomizer according to claim 1, characterized in that, The quantitative drug delivery controller supports user-configured multi-drug cross-nebulization, which means that multiple drugs can be cross-nebulized in a single or multiple optimal dose. In this case, before performing a single discrete nebulization operation for another nebulized drug, the quantitative drug delivery controller will control the quantitative drug delivery control block, drug channel and nebulization unit to perform a nebulization unit cleaning operation. The nebulized drug switching and nebulization unit cleaning operation are fully automated and require no manual intervention.

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