Measuring device and measuring method

Abstract

The present invention provides a measuring device and a measuring method, wherein the measuring device includes: a plurality of current applying units, which apply a plurality of alternating currents in a plurality of directions to a portion of a measuring object via an electrode pair; a magnetic field detecting element, which detects the magnitude of a magnetic field generated from a portion of the measuring object in response to the plurality of alternating currents; a calculating unit, which calculates the impedance of a portion of the measuring object based on the detection result of the magnetic field detecting element; and an internal information output unit, which generates information containing internal components of the measuring object based on the calculated impedance.

Description

Technical Field

[0001] The present invention relates to a measuring device and a measuring method for measuring internal information of a measurement object. Background Art

[0002] Magnetic resonance imaging (MRI) is known, which utilizes the nuclear magnetic resonance phenomenon to output information about the interior of a living body as a tomographic image. Also known are compact and highly sensitive magnetic sensors (see, for example, Patent Documents 1 and 2).

[0003] Prior art literature

[0004] Patent Literature

[0005] Patent Document 1: Japanese Patent No. 6506466

[0006] Patent Document 2: Japanese Patent No. 5839527 Summary of the Invention

[0007] Problems to be solved by the invention

[0008] MRI applies a static magnetic field from the outside to the organism being measured, magnetizing it macroscopically. This causes the atoms that make up the organism to precess. Therefore, when irradiated with a pulse of electromagnetic waves having a frequency consistent with the Larmor frequency of this precession, resonance occurs, and the rotational speed of this precession changes (a phenomenon known as nuclear magnetic resonance). Furthermore, when the irradiation of the electromagnetic wave pulses stops, the atomic precession returns to equilibrium. Because the process leading to the return to equilibrium (relaxation) varies from atom to atom, MRI generates an image based on these differences in relaxation and outputs this image as a tomographic image of the organism.

[0009] Thus, MRI observes the relaxation phenomenon until the precession of atoms returns to equilibrium, so at least the relaxation time must elapse before measurement results can be output. Meanwhile, to detect abnormalities within a living body, it is desirable to obtain multiple tomographic images at different locations within the body for evaluation. Even determining whether a portion of the body is normal or abnormal can require measurement times ranging from tens of minutes to over an hour.

[0010] Therefore, the present invention has been made in view of the above-mentioned circumstances, and an object thereof is to obtain information on the interior of a living body at high speed with a simple structure.

[0011] Means of solving problems

[0012] In a first embodiment of the present invention, a measuring device is provided, which includes: a plurality of current applying units, which apply a plurality of alternating currents in a plurality of directions to a portion of a measuring object via an electrode pair; a magnetic field detection element, which detects the magnitude of a magnetic field generated from a portion of the measuring object in response to the plurality of alternating currents; a calculation unit, which calculates the impedance of a portion of the measuring object based on a detection result of the magnetic field detection element; and an internal information output unit, which generates information including internal components of the measuring object based on the calculated impedance.

[0013] Alternatively, the current applying unit applies a plurality of the alternating currents to the first and second parts of the measurement object, the calculating unit calculates a first impedance based on a detection result of a magnetic field generated from the first part of the measurement object corresponding to the plurality of the alternating currents, and a second impedance based on a detection result of a magnetic field generated from the second part of the measurement object corresponding to the plurality of the alternating currents, and the internal information output unit generates information including a component of at least one of the first part and the second part by comparing the calculated first impedance with the second impedance.

[0014] Alternatively, the current applying unit may continuously apply a plurality of the alternating currents to at least a portion of the measurement object during a predetermined period, the calculating unit may calculate the impedance of a portion of the measurement object multiple times during the predetermined period, and the internal information output unit may generate information including internal components of the measurement object based on the change in the impedance of the portion of the measurement object over time.

[0015] Alternatively, a plurality of magnetic field detection elements may be arranged around the measurement object, at least a portion of the plurality of current applying portions scans the frequency of the alternating current applied to the measurement object, the calculation portion calculates the impedance of a portion of the measurement object and the frequency characteristics of the impedance corresponding to the frequency of the alternating current based on the detection results of the plurality of magnetic field detection elements, and the internal information output portion generates information including the internal state of the measurement object based on the calculated frequency characteristics of the impedance.

[0016] Alternatively, the measuring device further includes: a carrying portion having a ring shape or a part of a ring surrounding the measuring object and carrying a plurality of the current applying portions; and a moving portion that moves the carrying portion in a predetermined direction while maintaining the direction of the alternating current generated by the plurality of current applying portions relative to the measuring object.

[0017] The mounting portion may be equipped with one or more magnetic field detection elements.

[0018] Alternatively, the measuring device further includes: a static magnetic field applicator that applies a static magnetic field of a constant magnitude in a first direction to the measuring object; a deflection magnetic field applicator that applies a deflection magnetic field in a second direction different from the first direction and having a predetermined frequency to a portion of the measuring object via a coil; a relaxation detection element that detects a relaxation phenomenon of electromagnetic waves based on the deflection magnetic field generated in the portion of the measuring object by the deflection magnetic field applicator; and an MR image generator that generates and outputs a magnetic resonance image as a tomographic image of the interior of the measuring object based on a detection result of the relaxation detection element.

[0019] The measurement device may further include a specifying unit that specifies, based on the magnetic resonance image generated by the MR image generating unit, a site in the measurement object to be measured by applying the alternating current by the current applying unit.

[0020] Alternatively, the internal information output unit may further generate an internal image of the measurement object based on the calculated impedance, and the determination unit may determine a portion of the measurement object where the magnetic resonance image should be measured based on the internal image of the measurement object generated by the internal information output unit.

[0021] Alternatively, the internal information output unit further generates an image of the interior of the measurement object based on the calculated impedance, and the measurement device also includes a determination unit that determines, based on the image of the interior of the measurement object generated by the internal information output unit, a part of the measurement object to which the alternating current should be applied by the current application unit and to which the state should be observed.

[0022] Alternatively, the measuring device may include an MR image measuring device, the MR image measuring device comprising: a static magnetic field applying unit for applying a static magnetic field of a constant magnitude in a first direction to a measuring object; a deflection magnetic field applying unit for applying a deflection magnetic field in a second direction different from the first direction and having a predetermined frequency to a portion of the measuring object via a coil; a relaxation detecting element for detecting electromagnetic waves generated in the portion of the measuring object due to application of the deflection magnetic field and a relaxation phenomenon of the generated electromagnetic waves; and an MR image generating unit for generating and outputting a magnetic resonance image as a tomographic image of the interior of the measuring object based on a detection result of the relaxation detecting element. The MR image measuring device may further include: a plurality of current applying units provided around the measuring object; at least some of the plurality of current applying units sweeping the frequency of the alternating current applied to the measuring object; the calculating unit calculating a frequency characteristic of impedance corresponding to the frequency of the alternating current; and the internal information output unit generating information indicating the internal state of the measuring object based on the calculated frequency characteristic of impedance.

[0023] The measurement device may further include a specifying unit that specifies a site in the measurement object to which the alternating current should be applied by the current applying unit, based on the magnetic resonance image generated by the MR image generating unit.

[0024] Alternatively, the internal information output unit may further generate an internal image of the measurement object based on the calculated impedance, and the determination unit may determine a portion of the measurement object where the magnetic resonance image should be measured based on the internal image of the measurement object generated by the internal information output unit.

[0025] In a second embodiment of the present invention, a measuring method is provided, which includes the following steps: applying multiple alternating currents in multiple directions to a part of a measuring object via an electrode pair; detecting the magnitude of a magnetic field generated from a part of the measuring object corresponding to the multiple alternating currents; calculating the impedance of the part of the measuring object based on the detection result of the magnetic field; and generating and outputting information representing the internal components of the measuring object based on the calculated impedance.

[0026] Alternatively, the step of applying a plurality of the alternating currents includes the following steps: scanning the frequency of at least a part of the plurality of alternating currents applied to the measuring object; the step of detecting the size of the magnetic field generated from a part of the measuring object includes the following steps: detecting the size of the magnetic field generated from a part of the measuring object corresponding to the plurality of alternating currents at a plurality of positions around the measuring object; the step of calculating the impedance of a part of the measuring object includes the following steps: calculating the frequency characteristics of the impedance corresponding to the frequency of the alternating current; and the step of generating information representing the internal state of the measuring object includes the following steps: generating information including the internal state of the measuring object based on the calculated frequency characteristics of the impedance.

[0027] Alternatively, the measuring method further includes the following steps: applying a plurality of alternating currents in a plurality of directions from the periphery of the measuring object to a portion of the measuring object via an electrode pair; detecting the magnitude of the magnetic field generated from a portion of the measuring object corresponding to the plurality of alternating currents at a plurality of positions around the measuring object; calculating the impedance of a portion of the measuring object based on the detection result of the magnetic field; generating an image of the interior of the measuring object based on the calculated impedance; and determining a portion of the measuring object to which the alternating current should be applied and measured based on the image of the interior of the measuring object, wherein, after the step of determining the portion to which the alternating current should be applied and measured, the second mode of measuring method is executed to generate information indicating the state of the determined portion to be measured.

[0028] Alternatively, the measurement method further comprises the following steps: applying a plurality of alternating currents in a plurality of directions from the periphery of the measurement object to a portion of the measurement object via an electrode pair; detecting, at a plurality of positions around the measurement object, the magnitude of a magnetic field generated from a portion of the measurement object in response to the plurality of alternating currents; calculating the impedance of a portion of the measurement object based on the detection result of the magnetic field; generating an image of the interior of the measurement object based on the calculated impedance; determining a portion of the measurement object where a magnetic resonance image should be generated based on the image of the interior of the measurement object; applying a static magnetic field of a constant magnitude in a first direction to the measurement object; and applying a static magnetic field of a constant magnitude to the measurement object via a coil to the measurement object. A deflection magnetic field having a predetermined frequency and in a second direction different from the first direction is applied to a portion of the object to be measured where the magnetic resonance image should be generated; electromagnetic waves generated at the portion of the object to be measured due to the application of the deflection magnetic field in the second direction and a relaxation phenomenon of the generated electromagnetic waves are detected; based on the detection result, the magnetic resonance image is generated and output as a tomographic image of the interior of the object to be measured; and based on the magnetic resonance image, a portion of the object to be measured to which the alternating current should be applied and to which the measurement should be determined, wherein, after the step of determining the portion to which the alternating current should be applied and to which the measurement should be measured, a second mode of measurement method is executed to generate information representing the state of the determined portion to be measured.

[0029] Effects of the Invention

[0030] According to the present invention, it is possible to obtain information on the interior of a living body at high speed with a simple structure. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 A first configuration example of the measurement device 100 according to this embodiment is shown together with the measurement object 10 .

[0032] Figure 2 An example of the configuration of the carrying unit 140 and the control unit 160 according to this embodiment is shown together with the measurement object 10 .

[0033] Figure 3 A modified example of the measurement device 100 according to this embodiment is shown together with the measurement object 10 .

[0034] Figure 4 Shown Figure 3 The illustrated diagram is an example of the operation flow of the measurement device 100 according to this modification.

[0035] Figure 5 An example of the configuration of a detection device 400 according to this embodiment is shown together with the MR imaging device 300 .

[0036] Figure 6A second configuration example of the measurement device 100 according to this embodiment is shown together with the measurement object 10 .

[0037] Figure 7 A modified example of the measuring device 100 according to the second configuration example of the present embodiment is shown together with the measurement object 10 .

[0038] Figure 8 Shown Figure 7 The illustrated diagram is an example of the operation flow of the measurement device 100 according to this modification.

[0039] Figure 9 An example of the configuration of the detection device 600 according to this embodiment is shown together with the MR imaging device 300 .

[0040] Figure 10 A third configuration example of the measurement device 100 according to this embodiment is shown together with the measurement object 10 .

[0041] Figure 11 An example of the operation flow of the measurement device 100 of the third structural example is shown.

[0042] Figure 12 A fourth configuration example of the measurement device 100 according to this embodiment is shown together with the measurement object 10 . DETAILED DESCRIPTION

[0043] <First Configuration Example of Measurement Device 100>

[0044] Figure 1 A first structural example of a measuring device 100 according to this embodiment is shown together with a measuring object 10. The measuring device 100 of the first structural example outputs information about the interior of the measuring object 10 as a tomographic image. The measuring device 100 applies a deflection magnetic field to the measuring object 10 to which a static magnetic field is applied, and obtains information about the interior of the measuring object 10 based on electromagnetic waves generated in response to the application of the deflection magnetic field. The measuring object 10 is, for example, a living organism such as a human body. In this embodiment, an example in which the measuring object 10 is a human body will be described. The measuring device 100 includes a static magnetic field applying unit 110, a deflection magnetic field applying unit 120, a magnetic field detecting element 130, a carrying unit 140, a moving unit 150, a control unit 160, and a display unit 170.

[0045] The static magnetic field applying unit 110 applies a static magnetic field having a constant magnitude in a first direction to the measurement object 10 . Figure 1 An example is shown in which a human body as the measurement object 10 stands upright on the ground parallel to the XY plane. Figure 1, the first direction is shown as a direction substantially parallel to the Z direction. The Z direction is the height direction of the human body, that is, a direction perpendicular to the ground. The static magnetic field applying unit 110 applies a static magnetic field of the same magnitude as that of the static magnetic field used in MRI, etc., that is, a few T (Tesla), to the entire measurement object 10. In addition, the static magnetic field applying unit 110 may also apply a static magnetic field of less than a few T. For example, the static magnetic field applying unit 110 applies a static magnetic field of a magnitude greater than that of the earth's magnetism, that is, 100 μT or more, to the measurement object 10. The static magnetic field applying unit 110 has, for example, a Helmholtz coil.

[0046] The deflection magnetic field applying unit 120 applies a deflection magnetic field having a predetermined frequency and in a second direction different from the first direction to a portion of the measurement object 10 via a coil. The predetermined frequency is set based on the magnitude of the static magnetic field output by the static magnetic field applying unit 110 and is, for example, a frequency ranging from several kHz to several hundred kHz.

[0047] The second direction is determined based on the region to be observed of the object 10 and is one or more directions different from the first direction. The deflection magnetic field applying unit 120 applies one or more deflection magnetic fields toward a portion of the object 10 in one or more directions different from the first direction.

[0048] The deflection magnetic field applying unit 120 includes one or more magnetic field generating coils. For example, the magnetic field generating coils are Helmholtz coils. The deflection magnetic field applying unit 120 is preferably capable of applying deflection magnetic fields in various directions to the measurement object 10. At least six deflection magnetic field applying units 120 are provided to apply deflection magnetic fields in six directions, for example, the ±X, ±Y, and ±Z directions.

[0049] In this case, the six deflection magnetic field applying units 120 are preferably arranged so that, by controlling the magnitude of the deflection magnetic field outputted from each unit, deflection magnetic fields of various magnitudes and directions can be applied to any portion of the measurement object 10. Furthermore, each deflection magnetic field applying unit 120 can be movably provided so that the deflection magnetic field can be applied to various portions of the measurement object 10.

[0050] Magnetic field detection elements 130 are arranged around the measurement object 10 and each detects the magnitude of the magnetic field based on the electromagnetic waves generated and propagated in a portion of the measurement object 10 due to the application of the deflection magnetic field. Preferably, a plurality of magnetic field detection elements 130 are arranged to surround the measurement object 10. Magnetic field detection elements 130 are, for example, highly sensitive magnetic sensors capable of detecting weak magnetic fields in units of nT (nanotesla), pT (picotesla), and fT (femtotesla).

[0051] The carrying portion 140 carries at least a portion of the deflection magnetic field applying unit 120. The carrying portion 140 has, for example, a ring shape or a portion of a ring surrounding the measurement object 10, and carries a plurality of deflection magnetic field applying units 120. Furthermore, the carrying portion 140 carries at least a portion of the plurality of magnetic field detection elements 130. Figure 1 An example is shown in which a part of the deflection magnetic field applying section 120 and all of the magnetic field detection elements 130 are mounted on the mounting section 140 .

[0052] Using such a mounting portion 140, the deflection magnetic field applying unit 120 can apply multiple deflection magnetic fields in multiple directions different from the first direction from the multiple deflection magnetic field applying units 120 toward a portion of the measurement object 10. Furthermore, the multiple magnetic field detecting elements 130 can each detect magnetic fields generated in multiple directions by the application of the multiple deflection magnetic fields.

[0053] The moving unit 150 moves the carrying unit 140 in a predetermined direction while maintaining the orientation of the deflection magnetic fields generated by the plurality of deflection magnetic field applicators 120 relative to the measurement object 10. The moving unit 150 moves the carrying unit 140 relative to the measurement object 10 in a parallel direction or a perpendicular direction. Figure 1 The example in which the moving unit 150 moves the carrying unit 140 in a first direction is shown. The moving unit 150 is preferably capable of moving the carrying unit 140 so as to apply a deflection magnetic field to a specific portion of the human body, from the toes to the top of the head. Alternatively, the moving unit 150 may be moved so as to rotate the carrying unit 140 about the measurement object 10.

[0054] It should be noted that the carrying portion 140 may also have a cylindrical shape that surrounds the measurement object 10. The carrying portion 140 may, for example, have a cylindrical shape extending along the first direction. In this case, the deflection magnetic field application unit 120 and the magnetic field detection element 130 may be arranged at multiple different positions on the carrying portion 140. Furthermore, for example, if the carrying portion 140 is large enough to cover the measurement object 10, it is preferable to configure multiple deflection magnetic field application units 120 so that the deflection magnetic field can be applied to specific locations on the human body, from the toes to the top of the head. As an example, the cylindrical carrying portion 140 may have the shape of multiple rings or portions of rings that surround the measurement object 10. In this case, since the deflection magnetic field can be applied to any location on the measurement object 10 without moving the carrying portion 140, the movable portion 150 may not be required.

[0055] The control unit 160 controls the operation of the static magnetic field applicator 110, the deflection magnetic field applicator 120, the magnetic field detection element 130, the carrying unit 140, and the moving unit 150. For example, the control unit 160 controls the timing of applying the static magnetic field by the static magnetic field applicator 110 and the timing of applying the deflection magnetic field by the deflection magnetic field applicator 120. The control unit 160 controls the detection timing of the magnetic field detection element 130. Furthermore, the control unit 160 controls the moving unit 150 to move the carrying unit 140. Furthermore, the control unit 160 acquires the detection results detected by the magnetic field detection element 130. Based on the acquired detection results, the control unit 160 generates a tomographic image of the measurement object 10. The control unit 160 is, for example, a computer such as a server.

[0056] <Configuration Example of Mounting Unit 140 and Control Unit 160>

[0057] Figure 2 An example of the configuration of the carrying unit 140 and the control unit 160 according to this embodiment is shown together with the measurement object 10 . Figure 2 The carrying portion 140 and the measurement object 10 show the Figure 1 An example of a structure of a cross section of the measuring device 100 on a surface parallel to the XY plane. Figure 1 As described above, the mounting portion 140 mounts the plurality of deflection magnetic field applying units 120 and the plurality of magnetic field detection elements 130 .

[0058] The mounting portion 140 is provided with a deflection magnetic field applying unit 120 and a magnetic field detecting element 130 at predetermined intervals along the circumference of a ring shape, for example. The deflection magnetic field applying unit 120 is configured to apply a deflection magnetic field in a predetermined direction. The magnetic field detecting element 130 is configured to detect the magnetic field generated by the measurement object 10.

[0059] While the static magnetic field application unit 110 is applying a static magnetic field to the object 10, the control unit 160 causes the deflection magnetic field application unit 120 to apply a deflection magnetic field to the object 10. This applies the deflection magnetic field while the object 10 is macroscopically magnetized. Consequently, similar to MRI operation, when the frequency of the deflection magnetic field matches the Larmor frequency of the precession motion of the atoms constituting the object 10, nuclear magnetic resonance occurs. Specifically, the rotational speed of the precession motion of the atoms constituting the object 10 that are exposed to the deflection magnetic field changes. This change in precession causes the atoms exposed to the deflection magnetic field to generate electromagnetic waves that differ from those in their equilibrium state.

[0060] Whether or not such atomic nuclear magnetic resonance occurs is determined by the type of atoms, the density of the atoms, the magnitude of the static magnetic field, the frequency of the deflection magnetic field, and the like. For example, when the magnitude of the static magnetic field is approximately 0.1T to 2T (i.e., the level used in MRI), nuclear magnetic resonance of hydrogen atoms in the human body can be induced by setting the frequency of the deflection magnetic field to approximately several hundred kHz. Furthermore, when the magnitude of the static magnetic field is approximately tens of μT, nuclear magnetic resonance of hydrogen atoms in the human body can be induced by setting the frequency of the deflection magnetic field to approximately several kHz.

[0061] The magnetic field detection element 130 detects the magnetic field component of the electromagnetic wave generated by this nuclear magnetic resonance. It should be noted that the deflection magnetic field application unit 120 applies a deflection magnetic field to a local part of the measurement object 10, for example. In the local part of the measurement object 10, eddy currents corresponding to the deflection magnetic field are generated. Eddy currents are currents whose magnitude corresponds to the impedance of the local part. Moreover, a magnetic field corresponding to the generated eddy currents is generated. The magnetic field detection element 130 detects the magnitude of the magnetic field generated in this way. In this way, the magnitude of the magnetic field detected by the magnetic field detection element 130 is based on the value of the electromagnetic wave propagated under the influence of the electrical characteristics of the path from the part where the deflection magnetic field is applied to the magnetic field detection element 130. The electrical characteristics of the path from the part where the deflection magnetic field is applied to the magnetic field detection element 130 are, for example, the impedance of organs and organs in the human body.

[0062] In other words, the magnitude of the magnetic field detected by the magnetic field detection element 130 corresponds to information about the interior of the human body through which the electromagnetic wave passes. Therefore, the control unit 160 controls the magnitude of the magnetic field output by the deflection magnetic field application unit 120, thereby applying a deflection magnetic field to multiple locations on the subject 10 and obtaining detection results from the magnetic field detection element 130 for each location to which the deflection magnetic field is applied. This allows the control unit 160 to obtain magnetic field detection results corresponding to the impedance distribution within the subject 10. By analyzing these detection results, the control unit 160 can generate an image of the information within the subject 10. The control unit 160 includes, for example, a storage unit 162, a calculation unit 164, and an image information output unit 166.

[0063] The storage unit 162 stores the detection results of the magnetic field detection element 130. Furthermore, the storage unit 162 may also store intermediate data, calculation results, thresholds, parameters, and the like generated (or utilized) during the operation of the measurement device 100. Furthermore, the storage unit 162 may provide the stored data to the requesting source upon request from various components within the measurement device 100.

[0064] The storage unit 162 may also store information such as an operating system (OS) and programs used by a server or other computer to function as the control unit 160. Furthermore, the storage unit 162 may store various information, including databases referenced when the programs are executed. For example, a computer such as a server functions as at least part of the storage unit 162, the calculation unit 164, and the image information output unit 166 by executing the programs stored in the storage unit 162.

[0065] The storage unit 162 includes, for example, a read-only memory (ROM) that stores the computer's basic input / output system (BIOS), and a random access memory (RAM) that serves as a work area. Furthermore, the storage unit 162 may include a large-capacity storage device such as a hard disk drive (HDD) and / or a solid-state drive (SSD). Furthermore, the computer may further include a graphics processing unit (GPU).

[0066] Based on the detection results from the multiple magnetic field detection elements 130, the calculation unit 164 calculates the impedance distribution of at least a portion of the region within the measurement object 10 where the electromagnetic waves propagate. For example, the calculation unit 164 calculates the impedance between the multiple regions by comparing and analyzing the magnitude of the magnetic fields of the electromagnetic waves propagating from the multiple regions. For example, the calculation unit 164 calculates the impedance distribution within the human body using a two-dimensional Fourier transform or the like.

[0067] The image information output unit 166 generates and outputs an image representing information about the interior of the measurement object 10 based on the impedance distribution. The calculation unit 164 and the image information output unit 166 use a known image reconstruction method as computed tomography to generate a tomographic image of the interior of the human body. It should be noted that since the image reconstruction method is a known technology, its detailed description is omitted here. In addition, the image information output unit 166 can also generate a three-dimensional image based on the two-dimensional tomographic image. The image information output unit 166 displays the generated image on a display device, etc. In addition, the image information output unit 166 can also store the generated image in the storage unit 162. Furthermore, the image information output unit 166 can store the generated image in an external database, etc. via a network, etc.

[0068] The display unit 170 displays one or more images generated by the image information output unit 166. As described above, the measurement device 100 according to this embodiment can output the impedance distribution within a living body, such as a human body, as a tomographic image. Since the impedance within the human body varies depending on the internal organs, the tomographic images output by the measurement device 100 can easily confirm the internal state of the human body.

[0069] The measuring device 100 applies a static magnetic field and a deflection magnetic field to the subject 10, generating nuclear magnetic resonance (NMR) and detecting electromagnetic waves generated by this NMR. Because this measuring device 100 calculates the impedance distribution, rather than observing relaxation until the NMR returns to equilibrium, as is done with MRI, it can output tomographic images of the interior of the subject 10 at a higher speed. Furthermore, tumors such as cancer that develop in organs sometimes exhibit impedances that differ from those of the organs. Therefore, the use of the measuring device 100 makes it possible to easily observe and distinguish between normal and abnormal conditions of organs that are difficult to observe with MRI.

[0070] As described above, the measuring device 100 outputs information about the interior of the measuring object 10 as an image by detecting electromagnetic waves propagated by the nuclear magnetic resonance phenomenon generated within the measuring object 10. Therefore, if electromagnetic waves can be detected, the magnitude of the static magnetic field applied to the measuring object 10 by the static magnetic field applicator 110 can be reduced to a magnitude smaller than the several T magnitude used in MRI and the like.

[0071] In this case, the magnitude of the magnetic field to be detected by magnetic field detection element 130 decreases proportionally to the magnitude of the static magnetic field. However, as described in Patent Documents 1 and 2, etc., highly sensitive magnetic sensors are already available, and thus the magnitude of the static magnetic field output by static magnetic field applicator 110 can be reduced to approximately mT to several hundred μT. This allows measurement device 100 to produce tomographic images of the interior of measurement object 10 in a compact and inexpensive manner, without requiring an expensive and large magnetic field generator that generates a strong magnetic field of several T.

[0072] It should be noted that high-sensitivity magnetic sensors, such as optically pumped magnetometers and superconducting quantum interference devices (SQUIDs), are also known, with high sensitivities in the order of fT or less. As described above, when a high-sensitivity magnetic sensor capable of detecting weak magnetic fields in the order of pT or less is used as magnetic field detection element 130, the magnitude of the static magnetic field output by static magnetic field applicator 110 can be further reduced.

[0073] For example, the static magnetic field application unit 110 may reduce the magnitude of the static magnetic field it outputs to approximately the same magnitude as the Earth's magnetic field. In this case, the measurement device 100 may use the Earth's magnetic field as a static magnetic field with a constant magnitude in the first direction. The deflection magnetic field application unit 120 then applies a deflection magnetic field in a second direction, different from the first direction of the Earth's magnetic field, to a portion of the measurement object 10 magnetized by the Earth's magnetic field.

[0074] In this measurement device 100, the static magnetic field applying unit 110 can be omitted, further reducing the size of the device. It should be noted that the measurement device 100 may further include a fixing unit that can be moved while fixing the measurement object 10 so that the first direction, which is the geomagnetic direction, aligns with the predetermined direction of the measurement object 10. Furthermore, this fixing unit may include a bed or the like, so that the measurement object 10 can be fixed while lying down.

[0075] In the measurement device 100 according to the present embodiment, the static magnetic field applying unit 110 is described as applying a static magnetic field of constant magnitude to the measurement object 10. However, the present invention is not limited thereto. Alternatively, the static magnetic field applying unit 110 may be configured to be able to vary the magnitude of the static magnetic field applied to the measurement object 10.

[0076] As described above, the resonant frequency that generates nuclear magnetic resonance in the measurement object 10 varies depending on the type of atoms, the magnitude of the static magnetic field, and the like. Therefore, by varying the magnitude of the static magnetic field applied to the measurement object 10 by the static magnetic field applicator 110, the resonant frequency corresponding to the atoms contained in the measurement object 10 can be varied. Therefore, the control unit 160 obtains detection results from the magnetic field detection element 130 for each magnitude of the static magnetic field output by the static magnetic field applicator 110. Consequently, the calculation unit 164 calculates the impedance distribution for each magnitude of the static magnetic field.

[0077] In this manner, the measuring device 100 scans the magnitude of the static magnetic field within a predetermined range to measure the frequency characteristics of the impedance distribution. For example, the frequency characteristics of the impedance distribution can be represented by plotting the frequency on the horizontal axis and the impedance values ​​at one or more locations on the vertical axis. Furthermore, a tomographic image of the impedance distribution can be generated for each of multiple resonant frequencies to serve as the frequency characteristics of the impedance distribution. By measuring the frequency characteristics of this impedance distribution, for example, determining the occurrence of nuclear magnetic resonance of multiple different atoms can be used, thereby obtaining more detailed internal information of the measured object 10.

[0078] While the measurement device 100 according to this embodiment has been described above as detecting electromagnetic waves based on the generation of nuclear magnetic resonance, the present invention is not limited thereto. Because the measurement device 100 can generate nuclear magnetic resonance within the measurement object 10, it can also observe relaxation phenomena until the nuclear magnetic resonance returns to equilibrium, as in MRI or other techniques. This measurement device 100 will be described below.

[0079] <Modification of the Measurement Device 100 of the First Configuration Example>

[0080] Figure 3 A modified example of the measuring device 100 of the first configuration example according to this embodiment is shown together with the measuring object 10. In the measuring device 100 of this modified example, Figure 1 and Figure 2 Components of the measurement device 100 according to the present embodiment shown in the figure that have substantially the same operation are denoted by the same reference numerals, and their descriptions are omitted. The measurement device 100 according to this modification includes a relaxation detection element 210 , an MR image generator 220 , and a determination unit 230 .

[0081] The relaxation detection element 210 detects the relaxation phenomenon of electromagnetic waves generated in a portion of the measurement object 10 due to the application of a deflection magnetic field. The relaxation detection element 210 is, for example, the same detection element as the magnetic field detection element 130. Alternatively, one or more of the multiple magnetic field detection elements 130 may further detect the process from detecting a magnetic field to the magnitude of that magnetic field returning to an equilibrium state, thereby functioning as the relaxation detection element 210. It should be noted that the relaxation phenomenon of electromagnetic waves is well known in MRI measurements, so its description is omitted here. The control unit 160 obtains the detection results of the relaxation phenomenon by the magnetic field detection element 130.

[0082] Based on the detection results of the relaxation detection element 210, the MR image generation unit 220 generates and outputs a magnetic resonance image as a tomographic image of the interior of the measurement subject 10. The MR image generation unit 220 generates a magnetic resonance image of the interior of the human body using, for example, a known image reconstruction method such as computed tomography. It should be noted that since the image reconstruction method is a known technique, a detailed description thereof is omitted here. As a result, the measurement device 100 can output magnetic resonance images on a smaller scale than conventional MRI devices without generating a strong magnetic field of several tesla.

[0083] In this manner, the measurement device 100 is configured to measure both the tomographic image and the magnetic resonance image of the impedance distribution of the measurement object 10. In this case, the measurement device 100 is preferably configured to switch between the tomographic image and the magnetic resonance image for measurement. Furthermore, the measurement device 100 is more preferably configured to specify a measurement position for the magnetic resonance image based on the measurement results of the tomographic image of the impedance distribution. In this case, the control unit 160 includes a determination unit 230.

[0084] The determination unit 230 determines the location within the subject 10 where a magnetic resonance image should be acquired based on one or more images representing information about the interior of the subject 10, generated by the image information output unit 166. Since tomographic images of the impedance distribution of the subject 10 can be measured at high speed as described above, they can be used, for example, to determine the location at which a magnetic resonance image should be acquired. In this case, the determination unit 230 can use the measurement results of multiple tomographic images to determine the location of the subject 10 where a magnetic resonance image should be acquired.

[0085] The determination unit 230, for example, determines a region in the tomographic image estimated to be abnormal as a measurement region for the magnetic resonance image based on image processing such as image comparison. Alternatively, after the image information output unit 166 displays the measurement results of the plurality of tomographic images on the display unit 170, the determination unit 230 may receive input from a user or the like regarding a region to be measured in the magnetic resonance image. The operation of this type of measurement device 100 will be described below.

[0086] <First Example of Operation Flow of Measurement Device 100>

[0087] Figure 4 Shown Figure 3 The illustrated example is an example of the operation flow of the measurement device 100 according to this modification. The measurement device 100 outputs a magnetic resonance image of the measurement subject 10 by executing the operation flow from S410 to S490.

[0088] First, the control unit 160 receives a request from a user or the like to start measurement of the measurement object 10 (S410). It is assumed that the measurement object 10 is arranged in a predetermined positional relationship relative to the static magnetic field application unit 110, the deflection magnetic field application unit 120, and the magnetic field detection element 130. Furthermore, the control unit 160 receives information on the measurement range of the measurement object 10. For example, the control unit 160 receives an indication of a measurement range such as the head, neck, chest, abdomen, waist, legs, or entire body. Based on the received information, the control unit 160 controls the moving unit 150 to move the carrying unit 140 to the measurement start point of the measurement range.

[0089] Next, the static magnetic field applying unit 110 applies a static magnetic field of a constant magnitude in a first direction to the measurement object 10 ( S420 ). The static magnetic field applying unit 110 applies a static magnetic field of a predetermined intensity level to the measurement object 10 .

[0090] Next, the deflection magnetic field applying unit 120 applies a deflection magnetic field having a predetermined frequency and in a second direction different from the first direction to a portion of the measurement object 10 (S430). The deflection magnetic field applying unit 120 applies the deflection magnetic field to the portion of the measurement object 10 corresponding to the received measurement range. The plurality of magnetic field detecting elements 130 then each detects the magnitude of the magnetic field based on the electromagnetic waves generated and propagated in the portion of the measurement object 10 due to the application of the deflection magnetic field (S440).

[0091] Next, the calculation unit 164 calculates the impedance distribution of at least a portion of the area within the measurement object 10 to which the electromagnetic wave propagates based on the detection result of the propagating electromagnetic wave (S450). The control unit 160 repeats the operations from S430 to S450 until the impedance distribution within the measurement range can be calculated (S460: "No"). The control unit 160, for example, changes the location where the deflection magnetic field is applied and calculates the impedance distribution for each location where the deflection magnetic field is applied. It should be noted that in order to change the location where the deflection magnetic field is applied, the control unit 160 can control the moving unit 150 to move the carrying unit 140.

[0092] If the impedance distribution within the measurement range can be calculated (S460: "Yes"), the image information output unit 166 generates and outputs an image representing information about the interior of the measurement object 10 based on the impedance distribution (S470). The image information output unit 166 generates, for example, one or more tomographic images corresponding to one or more impedance distributions. Alternatively or in addition, the image information output unit 166 may generate a 3D image of the interior of the measurement object 10. As an example, the image information output unit 166 displays the generated one or more images on the display unit 170.

[0093] Next, the determination unit 230 determines the portion of the interior of the subject 10 for which a magnetic resonance image should be acquired based on the generated one or more images representing information on the interior of the subject 10 (S480). The determination unit 230 receives input of the portion for which a magnetic resonance image should be acquired from, for example, a user of the measurement device 100 who has checked the image of the subject 10 displayed on the display 170.

[0094] Next, the control unit 160 acquires and outputs a magnetic resonance image of the determined portion of the measurement object 10 (S490). The acquisition of the magnetic resonance image can be performed using a known method. For example, the static magnetic field application unit 110 applies a static magnetic field of a constant magnitude in a first direction to the measurement object 10. Furthermore, the deflection magnetic field application unit 120 applies a deflection magnetic field having a predetermined frequency and a direction different from the first direction toward the determined portion of the measurement object 10. It should be noted that, in order to apply the deflection magnetic field to the determined portion of the measurement object 10, the control unit 160 can control the moving unit 150 to move the carrying unit 140.

[0095] The relaxation detection element 210 detects electromagnetic waves generated in a region of the subject 10 due to the application of a deflection magnetic field, as well as the relaxation phenomenon of the generated electromagnetic waves. Based on the detection results of the generated electromagnetic waves and the relaxation phenomenon of the electromagnetic waves, the MR image generator 220 generates and outputs a magnetic resonance image as a tomographic image of the interior of the subject. The MR image generator 220 displays the generated magnetic resonance image on, for example, the display 170. The MR image generator 220 may also display the magnetic resonance image together with the image of the interior of the subject 10 displayed by the image information output unit 166.

[0096] As described above, the measurement device 100 according to this modified example can determine the portion of the subject 10 to be observed where a magnetic resonance image should be acquired based on a tomographic image of the impedance distribution, and thereby measure the magnetic resonance image. Thus, the measurement device 100 can appropriately determine the portion of the subject 10 to be observed, using a simple configuration, and rapidly measure and output a magnetic resonance image.

[0097] It should be noted that Figure 4 The operational flow described in the preceding text is an example of an operational flow for a measurement device 100 equipped with a static magnetic field applicator 110, but is not limited thereto. The measurement device 100 may also measure a tomographic image of the impedance distribution after measuring a magnetic resonance image. It should be noted that when the measurement device 100 uses geomagnetism to measure internal images and magnetic resonance images of the measurement object 10, it is obvious that the same operation can be performed by applying a deflection magnetic field in a direction different from the first direction of the geomagnetic field to a portion of the measurement object 10, for example by omitting the operation of S420 performed by the static magnetic field applicator 110.

[0098] In the above-described embodiment, the measurement device 100 has been described as an example capable of rapidly measuring images of the interior of the measurement object 10. Furthermore, the measurement device 100 has been described as capable of measuring both a tomographic image of the impedance distribution of the measurement object 10 and a magnetic resonance image, and can switch between these two types of measurements. Alternatively, the measurement device 100 may be configured to measure only magnetic resonance images of the measurement object 10.

[0099] Furthermore, in the measurement device 100 according to the present embodiment, an example has been described in which the moving unit 150 moves the carrying unit 140 while the measurement object 10 is fixed. However, the present invention is not limited thereto. For example, the carrying unit 140 may be fixed, and the moving unit 150 may move the measurement object 10. In this case, it is preferable that the human body, which is the measurement object 10, is fixed on a bed, for example, and the moving unit 150 moves the bed.

[0100] <Configuration Example of Detection Device 400>

[0101] The measurement device 100 according to the present embodiment has been described as an example in which the measurement device 100 is an independent device, but the present invention is not limited thereto. The measurement device 100 may be a device that functions as an addition to an existing MR image measurement device that outputs magnetic resonance images. Figure 5 An example of the configuration of a detection device 400 according to this embodiment is shown together with the MR imaging device 300 .

[0102] The MR imaging apparatus 300 includes at least the static magnetic field applicator 110, the deflection magnetic field applicator 120, the mounting unit 140, the moving unit 150, the display unit 170, the relaxation detection element 210, and the MR image generator 220, which operate in the same manner as in the present embodiment. Furthermore, the MR imaging apparatus 300 includes a control unit 310, which controls each component to measure magnetic resonance images. Since the MR imaging apparatus 300 measures magnetic resonance images in substantially the same manner as described above, a detailed description thereof will be omitted here.

[0103] The detection device 400 is provided in the MR imaging device 300. In this case, the combination of the MR imaging device 300 and the detection device 400 functions as at least a portion of the measurement device 100 according to this embodiment. The detection device 400 includes a plurality of magnetic field detection elements 130, and a control unit 160 having a storage unit 162, a calculation unit 164, an image information output unit 166, and a determination unit 230.

[0104] The detection device 400 exchanges control signals and the like with the MR image measurement device 300, generating and outputting an image representing information about the interior of the measurement object 10. Furthermore, the detection device 400 may supply a control signal instructing the MR image measurement device 300 to measure a magnetic resonance image based on the image of the interior of the measurement object 10. This allows for a measurement device 100 that can fully utilize existing equipment and the like and acquire information about the interior of the measurement object 10 at high speed.

[0105] The measuring device 100 according to the present embodiment described above utilizes impedance distribution to observe the normal and abnormal conditions of organs that are difficult to observe using MRI. Preferably, such observation of the internal state of the human body can more accurately measure minute areas. Therefore, the measuring device 100 can also be configured to directly supply current to the subject 10 using an electrode pair, rather than indirectly using a coil. This improves the positional accuracy of the area to which the measuring device 100 supplies current. This type of measuring device 100 will be described below.

[0106] <Second Configuration Example of the Measurement Device 100: Measuring Normality / Abnormality of the Measurement Object by Applying Current>

[0107] Figure 6 A second configuration example of the measurement device 100 according to this embodiment is shown together with the measurement object 10. In the measurement device 100 of the second configuration example, Figure 1 Components of the measurement device 100 of the first exemplary configuration shown as having substantially the same operation are denoted by the same reference numerals, and their descriptions are omitted. The measurement device 100 of the second exemplary configuration outputs information on the internal state of the measurement subject 10. For example, the measurement device 100 applies a current to a human body to which a static magnetic field is applied, and acquires information on the normal and abnormal states of the human body's organs based on the magnetic field generated in response to the applied current.

[0108] The measuring device 100 includes a static magnetic field applying unit 110, a current applying unit 510, a magnetic field detecting element 130, a carrying unit 140, a moving unit 150, a control unit 160, and a display unit 170. In other words, the measuring device 100 of the second structural example includes the current applying unit 510 instead of the deflection magnetic field applying unit 120 of the measuring device 100 of the first structural example. Figure 1 The operations are the same as those described in , so the description is omitted here.

[0109] The current applying unit 510 applies an alternating current to the human body as the measurement object 10 via the electrode pair. The electrode pair is connected to an AC power supply, for example, and generates an electric field corresponding to the AC power supplied from the AC power supply. Preferably, the operation of the AC power supply is controlled by the control unit 160. The electrode pair has a positive electrode and a negative electrode formed in a manner separated by a predetermined distance. The shape of the positive electrode and the shape of the negative electrode can be set to a shape that can supply an alternating current to the part to be observed of the measurement object 10. In addition, it is preferred that the positive electrode and the negative electrode are arranged near the measurement object 10 so that the alternating current can be supplied to the part to be observed of the measurement object 10, or they can be arranged to be in contact with the measurement object 10.

[0110] The current applying unit 510 has one or more electrode pairs. Preferably, the current applying unit 510 is capable of applying a plurality of alternating currents corresponding to eddy currents generated by the deflection magnetic field in a plurality of directions different from the first direction to a portion of the measurement object 10. At least six current applying units 510 are provided so as to be able to apply alternating currents in six directions, for example, the ±X direction, the ±Y direction, and the ±Z direction. Preferably, the current applying unit 510 is configured to be able to apply alternating currents of various sizes and directions to any part of the measurement object 10. In addition, each of the current applying units 510 can also be movably provided so as to be able to apply alternating currents to various parts of the measurement object 10.

[0111] The alternating current applied by the current applying unit 510 is a current corresponding to the eddy current generated by the deflection magnetic field in the second direction different from the first direction in a part of the measurement object 10. In other words, the current applying unit 510 applies the same current to the local part of the measurement object 10 as that generated by the deflection magnetic field in the second direction different from the first direction. Figure 1 The deflection magnetic field applied by the deflection magnetic field applying unit 120 is shown as a current that generates the same eddy current as the deflection magnetic field. This generates a magnetic field corresponding to the alternating current corresponding to the impedance of the local area at a localized portion of the measurement object 10. It should be noted that the waveform of the alternating current can be a sine wave, a triangular wave, a rectangular wave, or other waveforms. Furthermore, it can also be a pulse wave, a decaying wave, a burst wave, or other waveforms.

[0112] The magnetic field detection element 130 detects the magnitude of the magnetic field generated in this way. The magnetic field detection element 130 of the second structural example respectively detects the magnitude of the magnetic field generated from a part of the measurement object 10 in accordance with the alternating current supplied by the current applying unit 510. One or more magnetic field detection elements 130 are provided near the measurement object 10. As already described, the magnetic field detection element 130 is, for example, arranged around the measurement object 10. Preferably, a plurality of magnetic field detection elements 130 are arranged in a manner surrounding the measurement object 10. In addition, it is preferred that a plurality of magnetic field detection elements 130 are provided so as to be able to detect magnetic fields in multiple directions. Thus, the magnetic field detection element 130 can, for example, detect the magnitude of the magnetic field corresponding to the impedance of an organ or the like in the human body as the measurement object 10.

[0113] The carrying portion 140 carries a plurality of current applying portions 510. As already explained, the carrying portion 140 has a ring shape or a portion of a ring shape surrounding the measurement object 10. In addition, the carrying portion 140 may also carry at least a portion of the plurality of magnetic field detection elements 130. The moving portion 150 moves the carrying portion 140 in a predetermined direction while maintaining the direction of the alternating current generated by one or more current applying portions 510 relative to the measurement object 10. Other operations of the carrying portion 140 and the moving portion 150 are similar to those already described. Figure 1 The operations are the same as those described in , so the description is omitted here.

[0114] The control unit 160 controls the operation of the static magnetic field applicator 110, the current applicator 510, the magnetic field detection element 130, the mounting unit 140, and the moving unit 150. For example, the control unit 160 controls the timing of applying the static magnetic field by the static magnetic field applicator 110 and the timing of applying the alternating current by the current applicator 510. Furthermore, the control unit 160 may also control the direction in which the alternating current is applied.

[0115] While the static magnetic field is being applied to the subject 10 by the static magnetic field applicator 110, the controller 160 causes the current applicator 510 to apply an alternating current to the subject 10. This applies the alternating current while the subject 10 is macroscopically magnetized. Consequently, similar to MRI operation, the rotational speed of the precession motion of the atoms constituting the subject 10 to which the alternating current is applied changes. This change in precession causes the atoms to generate electromagnetic waves different from those in their equilibrium state.

[0116] For example, the control unit 160 applies an alternating current to a portion of the measurement object 10 and obtains the detection results of the magnetic field detection element 130 corresponding to the portion to which the alternating current is applied. Thus, the control unit 160 can obtain the detection results of the magnetic field corresponding to the impedance of the portion within the measurement object 10 to which the alternating current is applied. Furthermore, the control unit 160 can apply an alternating current to multiple portions of the measurement object 10 and obtain the detection results of the magnetic field detection element 130 for each portion to which the alternating current is applied. Thus, the control unit 160 can obtain the detection results of the magnetic field corresponding to the impedance, impedance distribution, and the like within the measurement object 10.

[0117] The control unit 160 can generate information on the internal state of the measurement object 10 by analyzing such detection results. The control unit 160 includes, for example, a storage unit 162, a calculation unit 164, and an internal information output unit 566. The operations of the storage unit 162 and the calculation unit 164 are similar to those already described. Figure 1 It should be noted that the calculation unit 164 may also calculate the internal impedance of the measurement object 10 based on the detection result of the magnetic field detection element 130 at one location inside the measurement object 10.

[0118] The internal information output unit 566 generates and outputs information indicating the internal state of the measurement object 10 based on the impedance and / or impedance distribution calculated by the calculation unit 164. It should be noted that by using the impedance distribution, the internal information output unit 566 can generate information indicating the state of a wider range of regions. In this case, the internal information output unit 566 can also generate and output an image based on the impedance distribution. For example, the internal information output unit 566 generates information indicating abnormal conditions caused by tumors such as cancer that have developed in internal organs, etc. Furthermore, if an abnormal condition cannot be detected, the internal information output unit 566 generates information indicating that the internal organs, etc., are in a normal state. The display unit 170 displays the information indicating the internal state of the measurement object 10 generated by the internal information output unit 566.

[0119] As described above, the measuring device 100 of the second configuration example can efficiently measure the state of a living body, such as a human body, by supplying an alternating current to the site to be observed. Similar to the measuring device 100 of the first configuration example, the measuring device 100 of the second configuration example can also vary the magnitude of the static magnetic field applied to the measurement object 10 by the static magnetic field applicator 110 and calculate the impedance for each magnitude of the static magnetic field.

[0120] Similar to the measuring device 100 of the first exemplary configuration, the measuring device 100 of the second exemplary configuration can calculate impedance without observing the relaxation phenomenon until the nuclear magnetic resonance phenomenon returns to an equilibrium state, thereby enabling high-speed output of measurement results. Furthermore, the magnetic field detection element 130 utilizes a highly sensitive magnetic sensor such as those described in Patent Documents 1 and 2, enabling compact and inexpensive measurement of the internal state of the measurement object 10.

[0121] Furthermore, in the measurement device 100 of the second configuration example, when a highly sensitive magnetic sensor capable of detecting weak magnetic fields in the order of pT or less is used as the magnetic field detection element 130, the magnitude of the static magnetic field output by the static magnetic field application unit 110 can be further reduced. For example, even if the magnitude of the static magnetic field output by the static magnetic field application unit 110 is reduced to approximately several hundred times that of the Earth's magnetism, the internal state of the measurement object 10 can still be measured.

[0122] While the second exemplary configuration of the measuring device 100 has been described above as detecting a magnetic field by applying an alternating current, the present invention is not limited thereto. The measuring device 100 can generate nuclear magnetic resonance within the subject 10 or observe relaxation phenomena until the nuclear magnetic resonance returns to equilibrium, as in MRI or other techniques. The measuring device 100 can generate nuclear magnetic resonance by, for example, directly supplying current to the subject 10 using an electrode pair.

[0123] In this case, multiple current applicators 510 are arranged around the subject 10 so as to apply multiple alternating currents in multiple directions to a portion of the subject 10. Furthermore, the magnetic field detection element 130 detects the relaxation phenomenon of the magnetic field based on the multiple alternating currents generated in a portion of the subject 10 by the multiple current applicators 510. The calculation unit 164 calculates the internal impedance of the subject 10 in a time series. Consequently, the internal information output unit 566 can generate and output an image corresponding to a magnetic resonance image representing information about the interior of the subject 10 based on the calculated impedance changes.

[0124] In this case, the internal information output unit 566 can generate an image corresponding to the magnetic resonance image of the subject 10 by, for example, performing known signal processing on the impedance change. If the detection sensitivity of the magnetic field detection element 130 is sufficiently high, the internal information output unit 566 can output an image corresponding to the magnetic resonance image or an image having the same degree of accuracy as the magnetic resonance image. The display unit 170 can display an image corresponding to the magnetic resonance image generated by the internal information output unit 566 and, in addition to the image, can also display information indicating the internal state.

[0125] The measuring device 100 may include a unit for capturing a magnetic resonance image instead of the above-mentioned units, or in addition to the above-mentioned units.

[0126] <Modification of the Measurement Device 100 of the Second Configuration Example, Generation of MR Images and the Measurement Device of the First Configuration Example>

[0127] Figure 7 A modified example of the measuring device 100 according to the second configuration example of the present embodiment is shown together with the measuring object 10. In the measuring device 100 of this modified example, Figure 6 The measuring device 100 of the second configuration example shown has substantially the same operating parts as those in the second configuration example, and their description is omitted. The measuring device 100 of this modification includes a deflection magnetic field applying unit 120 , a relaxation detecting element 210 , an MR image generating unit 220 , and a determining unit 230 .

[0128] The deflection magnetic field applying unit 120 applies a deflection magnetic field having a predetermined frequency and directed in a second direction different from the first direction to a portion of the measurement subject 10 via a coil. The deflection magnetic field applying unit 120 includes multiple magnetic field generating coils and applies multiple deflection magnetic fields directed in multiple directions different from the first direction to a portion of the measurement subject 10. The operations of the deflection magnetic field applying unit 120, the relaxation detection element 210, and the MR image generating unit 220 are similar to those described in the modified example of the measurement device 100 of the first structural example, and therefore, description thereof will be omitted here.

[0129] In this manner, the measurement device 100 is configured to be able to perform both measurement of the internal information of the subject 10 using an alternating current and measurement of a magnetic resonance image. In this case, the measurement device 100 is preferably configured to be able to switch between measurement of the internal information of the subject 10 and measurement of a magnetic resonance image. Furthermore, the measurement device 100 is more preferably configured to be able to specify a location on the subject 10 for internal information measurement based on the measurement results of the magnetic resonance image. In this case, the control unit 160 includes a determination unit 230.

[0130] The identification unit 230 identifies the portion of the subject 10 to which the alternating current should be applied by the current applicator 510 based on the magnetic resonance image generated by the MR image generator 220. The magnetic resonance image displays positional information within the subject 10 at high spatial resolution. Therefore, the identification unit 230 can easily identify the portion of an internal organ to be observed, for example.

[0131] The determination unit 230 determines, based on image processing such as image analysis or image comparison, the site where the alternating current should be applied, based on the site estimated to be abnormal in the magnetic resonance image. Alternatively, after the display unit 170 displays the magnetic resonance image, the determination unit 230 may receive input from a user or the like regarding the site to which the alternating current should be applied. The operation of this measurement device 100 will be described below.

[0132] <Second Example of Operation Flow of Measurement Device 100>

[0133] Figure 8 Shown Figure 7 The illustrated example is an example of the operation flow of the measurement device 100 according to this modification. The measurement device 100 outputs information on the internal state of the measurement object 10 by executing the operation flow from S810 to S890.

[0134] First, the control unit 160 receives a measurement start request from a user or the like for the measurement object 10 (S810). The measurement object 10 is arranged to be in a predetermined positional relationship relative to the static magnetic field application unit 110, the deflection magnetic field application unit 120, the magnetic field detection element 130, and the current application unit 510. Furthermore, the control unit 160 receives information on the measurement range of the measurement object 10. For example, the control unit 160 receives an indication of a measurement range such as the head, neck, chest, abdomen, waist, legs, or the entire body. Based on the received information, the control unit 160 controls the moving unit 150 to move the carrying unit 140 to the measurement start point of the measurement range.

[0135] Next, the static magnetic field applying unit 110 applies a static magnetic field of a constant magnitude in a first direction to the measurement object 10 ( S820 ). The static magnetic field applying unit 110 applies a static magnetic field of a predetermined intensity level to the measurement object 10 .

[0136] Next, the deflection magnetic field applying unit 120 applies a deflection magnetic field having a predetermined frequency and in a second direction different from the first direction to the portion of the object 10 to be observed (S830). The deflection magnetic field applying unit 120 applies the deflection magnetic field to a portion of the object 10 corresponding to the received measurement range.

[0137] Next, the control unit 160 acquires and outputs a magnetic resonance image of the measurement range of the measurement object 10 (S840). The relaxation detection element 210 detects the electromagnetic waves generated by the applied deflection magnetic field and the relaxation phenomenon of the generated electromagnetic waves within the measurement range of the measurement object 10. Based on the detection results of the generated electromagnetic waves and the relaxation phenomenon of the electromagnetic waves, the MR image generator 220 generates and outputs a magnetic resonance image as a tomographic image of the interior of the measurement object. The MR image generator 220 displays the generated magnetic resonance image on, for example, the display unit 170.

[0138] Next, the identification unit 230 identifies the internal position of the measurement object 10 to be observed based on the magnetic resonance image (S850). The identification unit 230 receives input of the portion to be observed from, for example, a user of the measurement device 100 who has viewed the magnetic resonance image of the measurement object 10 displayed on the display unit 170. Alternatively, the identification unit 230 may identify the portion to be observed through image analysis.

[0139] Next, the current applying unit 510 applies an alternating current to the determined position inside the measurement object 10 (S860). Then, the plurality of magnetic field detecting elements 130 around the measurement object 10 respectively detect the magnitude of the magnetic field generated in a portion of the measurement object 10 due to the application of the alternating current (S870).

[0140] Next, the calculation unit 164 calculates the internal impedance of the measurement object 10 based on the magnetic field detection results (S880). The internal information output unit 566 generates and outputs information about the internal state of the measurement object 10 based on the impedance (S890). The internal information output unit 566 generates information such as whether the internal organ is normal, abnormal, or likely to be abnormal. The internal information output unit 566 displays the generated information on the display unit 170. The display unit 170 displays the internal state at the position corresponding to the measured internal organ in the magnetic resonance image, for example.

[0141] As described above, the measurement device 100 according to this variation identifies the portion of the subject 10 whose internal state should be acquired based on the magnetic resonance image. Thus, the measurement device 100 uses the positional information of the subject 10 measured with high spatial resolution to appropriately identify the portion to be observed, thereby enabling rapid measurement of the internal state.

[0142] It should be noted that Figure 8 The operational flow described in the preceding text is an example of an operational flow for a measurement device 100 equipped with a static magnetic field applicator 110, but is not limited thereto. When the measurement device 100 uses geomagnetism to measure an image of the interior of the measurement object 10 and a magnetic resonance image, for example, the operation of S820 performed by the static magnetic field applicator 110 may be omitted. Furthermore, the measurement device 100 may measure a magnetic resonance image after measuring the internal state.

[0143] Alternatively, the measuring device 100 may generate an image corresponding to a magnetic resonance image by applying an alternating current to the measuring subject 10, instead of applying a deflection magnetic field, as described above. In this case, the operation in S830 is, for example, an operation in which the multiple current applying units 510 apply multiple alternating currents in multiple directions to a portion of the measuring subject 10 from multiple locations around the measuring subject 10.

[0144] Furthermore, the operation at S840 is an operation in which the relaxation detection element 210 detects a relaxation phenomenon of the magnetic field generated in a portion of the measurement object 10 based on the multiple alternating currents. Then, the internal information output unit 566 generates and outputs an image corresponding to the magnetic resonance image representing information about the interior of the measurement object 10 based on the change in impedance calculated by the calculation unit 164.

[0145] It should be noted that in the operation of S850, the determination unit 230 determines, based on the image corresponding to the magnetic resonance image, the portion of the measurement object 10 to which the alternating current corresponding to the eddy current generated by the deflection magnetic field in the second direction should be applied. Thus, the determination unit 230 can also determine, based on the image corresponding to the magnetic resonance image, the portion of the measurement object 10 to which the alternating current should be applied and the state of the portion to be measured.

[0146] <Combination of the first structural example and the second structural example>

[0147] Furthermore, as described in the measurement device 100 of the first structural example, the measurement device 100 can also be configured to rapidly measure an image of the interior of the measurement object 10. In this case, the control unit 160 is further provided with an image information output unit 166 that generates and outputs an image representing information about the interior of the measurement object 10. Furthermore, the plurality of magnetic field detection elements 130 each detects the magnitude of a magnetic field based on electromagnetic waves generated and propagated through a portion of the measurement object 10 by the application of a deflection magnetic field by the deflection magnetic field application unit 120.

[0148] Calculation unit 164 then calculates the impedance distribution of at least a portion of the region within measurement target 10 where the electromagnetic wave propagates, based on the detection results of the plurality of magnetic field detection elements 130. Image information output unit 166 then generates an image representing information about the interior of measurement target 10 based on the impedance distribution calculated by calculation unit 164.

[0149] As from Figure 4 As described in S410 to S480, the measuring device 100 can quickly measure the tomographic image of the impedance distribution of the measuring object 10, thereby determining the measurement range of the magnetic resonance image to be observed. Figure 8 As described in S830 to S850 of FIG. 1 , the measuring device 100 can determine the part where the magnetic resonance image should be observed and the internal state should be observed. Figure 8 As described in S860 to S890 , the measurement device 100 can appropriately identify the position of the interior of the measurement object 10 to be observed and quickly measure the internal state.

[0150] It should be noted that, when the measuring device 100 does not require a spatial resolution as high as that of a magnetic resonance image, the determination unit 230 may determine the internal position to be observed based on a tomographic image of the impedance distribution of the measuring object 10. The measuring device 100 can measure the internal state of the measuring object 10 at a higher speed without using a magnetic resonance image. The measuring device 100 may also be configured for such a purpose. In this case, the relaxation detection element 210 and the MR image generation unit 220 may not be provided. In this case, the measuring device 100 is provided with Figure 1 The function of the first structural example described in Figure 6 The functional device of the second structural example described in the present invention.

[0151] <Configuration Example of Detection Device 600, Configuration Added to MR Image Measurement Device>

[0152] Although the second configuration example has been described above with the measurement device 100 being an independent device, the present invention is not limited thereto. Figure 5 Similar to the detection device 400 described above, the detection device may be a device that is added to an existing MR image measurement device that outputs a magnetic resonance image and functions accordingly. Figure 9 An example of the configuration of the detection device 600 according to this embodiment is shown together with the MR imaging device 300 .

[0153] The MR image measuring apparatus 300 includes at least the static magnetic field applying unit 110, the deflection magnetic field applying unit 120, the carrying unit 140, the moving unit 150, the display unit 170, the relaxation detection element 210, and the MR image generating unit 220 according to the present embodiment, and is configured to operate in the same manner. Furthermore, the MR image measuring apparatus 300 includes a control unit 310, which controls each component to measure magnetic resonance images. Since the measurement of magnetic resonance images by the MR image measuring apparatus 300 is substantially the same as the above-described operation, a description thereof will be omitted here.

[0154] The detection device 600 is provided in the MR imaging measurement device 300. In this case, the MR imaging measurement device 300 and the detection device 600 are combined to function as at least a portion of the measurement device 100 according to this embodiment. The detection device 600 includes a current application unit 510, a plurality of magnetic field detection elements 130, and a control unit 160 including a storage unit 162, a calculation unit 164, a determination unit 230, and an internal information output unit 566.

[0155] The detection device 600 exchanges control signals and other signals with the MR imaging device 300, generating and outputting information indicating the internal state of the subject 10. Furthermore, the detection device 600 receives the magnetic resonance image generated by the MR imaging device 300 to identify the location of the subject 10 where the internal state should be observed. Based on the identified location for observing the internal state, the detection device 600 provides the MR imaging device 300 with a control signal instructing the application of an alternating current. This allows for a measurement device 100 that can efficiently acquire the internal state of the subject 10 while fully utilizing existing equipment.

[0156] In the aforementioned second exemplary configuration, the measurement device 100 has been described as being capable of distinguishing between abnormal and normal states of the measurement object 10 by applying an alternating current to the measurement object 10 while a static magnetic field is applied. Furthermore, while the measurement device 100 has been described as being capable of identifying the site to be measured based on images generated by the measurement device 100 of the first exemplary configuration or the MR imaging measurement device 300, this is not limiting. The measurement device 100 can identify the site to be measured as long as any device can output an image of the interior of the measurement object 100.

[0157] For example, the measuring device 100 may be combined with a device that outputs an image of the interior of the measuring object 10 by applying alternating current in multiple directions. Furthermore, the measuring device 100 may also include a current applying unit 510 that applies alternating current to the measuring device 100, thereby enabling such a function. Therefore, a device having such a function will be described below.

[0158] <Third Configuration Example of the Measurement Device 100: Measuring the Internal Image of the Measurement Object by Applying Current>

[0159] Figure 10 A third configuration example of the measuring device 100 according to this embodiment is shown together with the measuring object 10. The measuring device 100 of the third configuration example applies an alternating current to the measuring object 10 without applying a static magnetic field, thereby outputting an image of the interior of the measuring object 10. Furthermore, as described above, the measuring device 100 applies a static magnetic field and an alternating current to the measuring object 10 to distinguish between abnormal and normal states of the measuring object 10.

[0160] The measuring device 100 includes a static magnetic field applying unit 110, a magnetic field detecting element 130, a carrying unit 140, a moving unit 150, a control unit 160, a display unit 170, a determination unit 230, and a current applying unit 510. In other words, the measuring device 100 of the third structural example has a structure substantially the same as that of the measuring device 100 of the second structural example. Figure 6Parts of the measurement device 100 of the second configuration example shown that have substantially the same operations are denoted by the same reference numerals, and description thereof will be omitted.

[0161] Multiple current applicators 510 are provided around the measurement object. The current applicators 510 apply multiple alternating currents in multiple directions to a portion of the measurement object 10. Furthermore, multiple magnetic field detection elements 130 are arranged around the measurement object 10, each detecting the magnitude of the magnetic field generated from a portion of the measurement object 10 in response to the multiple applied alternating currents. In this case, the calculation unit 164 calculates the impedance distribution within the measurement object based on the detection results of the multiple magnetic field detection elements 130.

[0162] When no static magnetic field is applied to the measurement object 10, the impedance distribution calculated by the calculation unit 164 corresponds to the lines of force generated by the application of an alternating current to the interior of the measurement object 10. Furthermore, by applying an alternating current to the interior of the measurement object 10 from multiple directions and calculating the impedance distribution by the calculation unit 164, an impedance distribution corresponding to the internal structure of the measurement object 10 can be obtained.

[0163] Therefore, the internal information output unit 566 can generate and output an image representing information about the interior of the measurement object 10 based on the calculated impedance distribution. The internal information output unit 566 processes the impedance distribution using, for example, known numerical analysis to generate a tomographic image of a portion of the measurement object 10. Thus, the measurement device 100 of the third configuration example can output a tomographic image of the measurement object 10 more quickly and easily than, for example, an MR measurement device.

[0164] It should be noted that at least some of the multiple current applying units 510 may also sweep the frequency of the alternating current applied to the measurement object 10. In this case, the calculation unit 164 can calculate the frequency characteristics of the impedance corresponding to the frequency of the alternating current. Furthermore, the internal information output unit 566 can generate the internal state of the measurement object 10 based on the frequency characteristics of the impedance.

[0165] An induced magnetic field is generated within the measurement object 10 in response to the applied alternating current. The frequency of the generated induced magnetic field corresponds to the frequency of the applied alternating current. Therefore, by sweeping the frequency of the alternating current while keeping the location where the alternating current is applied fixed, the spectral distribution of the generated induced magnetic field can be obtained. The spectral distribution of the induced magnetic field corresponds to, for example, a human organ.

[0166] Therefore, by analyzing the spectral distribution of the induced magnetic field, it is possible to identify the organ where the AC current is applied. Furthermore, even within the same organ, the spectral distribution of the induced magnetic field can sometimes differ between normal cells and abnormal cells. Therefore, based on the spectral distribution of the induced magnetic field, it is possible to determine whether the organ where the AC current is applied is normal. As an example, the internal information output unit 566 determines whether the area where the AC current is applied is normal by comparing the acquired spectral distribution with the spectral distribution of normal organs measured previously.

[0167] The determination unit 230 determines the portion of the measurement object 10 to which the alternating current should be applied by the current application unit 510 and the state should be detected based on the image representing the internal information of the measurement object 10 generated by the internal information output unit 566. For example, the determination unit 230 receives information about the portion to be detected from the user of the measurement device 100. Here, the user can determine the portion to be detected from the image of the interior of the measurement object 10 including the information about the organ. Figure 6 As described above, the measurement device 100 measures the state of the identified portion by applying a static magnetic field and an alternating current to the identified portion, for example.

[0168] <One Example of Operation Flow of the Measurement Device 100 of the Third Configuration Example>

[0169] Figure 11 An example of the operation flow of the measurement device 100 of the third configuration example is shown. The measurement device 100 outputs information on the internal state of the measurement object 10 by executing the operation flow from S1110 to S1180.

[0170] First, the control unit 160 receives a measurement start request from a user or the like for the measurement object 10 (S1110). The measurement object 10 is arranged to be in a predetermined positional relationship relative to the static magnetic field application unit 110, the magnetic field detection element 130, and the current application unit 510. In addition, the control unit 160 also receives information on the measurement range of the measurement object 10. For example, the control unit 160 receives an indication of a measurement range such as the head, neck, chest, abdomen, waist, legs, or the whole body. Based on the received information, the control unit 160 controls the moving unit 150 to move the carrying unit 140 to the measurement start point of the measurement range.

[0171] Next, the multiple current applying sections 510 apply alternating currents in multiple directions toward the determined positions inside the measuring object 10 (S1120). The multiple magnetic field detecting elements 130 are around the measuring object 10, and each detects the magnitude of the magnetic field generated in a portion of the measuring object 10 due to the application of the alternating current (S1130). It should be noted that the multiple current applying sections 510 apply multiple alternating currents to the measuring object 10 one by one, for example, in a predetermined order. In this case, the applying current in S1120 and the detecting magnetic field in S1130 can be repeated. In addition, the current applying section 510 of at least a portion of the multiple current applying sections 510 can also scan the frequency of the alternating current applied to the measuring object 10.

[0172] Next, the calculation unit 164 calculates the impedance distribution within the measurement object 10 based on the magnetic field detection results (S1140). The internal information output unit 566 generates and outputs an image representing information about the interior of the measurement object 10 based on the impedance distribution (S1150). It should be noted that the operation flow from S1110 to S1150 can be executed multiple times to obtain images of multiple locations.

[0173] Next, the determination unit 230 determines the portion of the measurement object 10 to which the alternating current should be applied by the current application unit 510 and the state to be observed based on the image of the interior of the measurement object 10 generated by the internal information output unit 566 (S1160). The determination unit 230 receives input of the portion to be observed from, for example, a user of the measurement device 100 who has viewed the image of the interior of the measurement object 10 displayed on the display unit 170. Alternatively, the determination unit 230 may determine the portion to be observed through image analysis.

[0174] Next, the static magnetic field applying unit 110 applies a static magnetic field of a constant magnitude in a first direction to the measurement object 10 (S1170). The static magnetic field applying unit 110 applies a static magnetic field of a predetermined intensity level to the measurement object 10. Furthermore, the measurement device 100 generates and outputs information on the internal state of the measurement object 10 (S1180). It should be noted that the operation of S1180 is the same as that of Figure 8 The operations from S860 to S890 described in are the same, so the description is omitted here.

[0175] As described above, the measuring device 100 of the third configuration example identifies a portion of the measuring object 10 whose internal condition is to be measured based on images of the interior of the measuring object 10 acquired by applying alternating current in multiple directions. Thus, the measuring device 100 uses positional information of the measuring object 10 measured with high spatial resolution to appropriately identify the portion to be observed, thereby enabling rapid measurement of the internal condition.

[0176] It should be noted that the measuring device 100 of the third structural example can also measure the internal state of the measuring object 10 by sweeping the frequency of the alternating current applied by the current applying unit 510 to the measuring object 10. In this case, the measuring device 100 does not perform the operation of S1170, but instead applies an alternating current from the current applying unit 510 to the location inside the measuring object 10 determined by the determining unit 230 and whose state is to be observed, and sweeps the frequency of the alternating current. Then, the calculating unit 164 calculates the frequency characteristic of the impedance corresponding to the frequency of the alternating current, and the internal information output unit 566 generates and outputs the internal state of the measuring object 10 based on the frequency characteristic of the impedance (S1180). This measuring device 100 does not need to include the static magnetic field applying unit 110.

[0177] As described above, the measuring device 100 can acquire a tomographic image of the interior of the measuring object 10 using a simple configuration that applies alternating current to the measuring object 10 from multiple directions and detects the resulting magnetic field. Thus, the measuring device 100 can, using a simple configuration, determine the portion of the measuring object 10 whose internal condition should be measured based on the acquired tomographic image, and thereby measure the condition of that portion. Furthermore, because the measuring device 100 can utilize the common current applicator 510 and magnetic field detection element 130 to both acquire a tomographic image of the measuring object 10 and measure its internal condition, the device configuration can be simplified, and the cost of the device can be reduced.

[0178] <Modification of the Measurement Device 100 of the Third Configuration Example>

[0179] The measuring device 100 of the third structural example can also be combined with the other structures described in the measuring device 100 of the first structural example and the measuring device 100 of the second structural example. Figure 7 As described in [ 15 ], the measurement device 100 of the third configuration example may further include a deflection magnetic field applicator 120, a relaxation detection element 210, and an MR image generator 220, and may also have a function for measuring magnetic resonance images. In this case, the identification unit 230 identifies a portion of the measurement object 10 where a magnetic resonance image should be measured based on the image of the interior of the measurement object 10 generated by the internal information output unit 566. Furthermore, the identification unit 230 identifies a portion of the measurement object 10 where an alternating current should be applied by the current applicator 510 and the state should be detected based on the magnetic resonance image generated by the MR image generator 220.

[0180] In this case, the measuring device 100 performs one or more Figure 11The operation flow from S1110 to S1150 is used to obtain tomographic images of one or more regions of the measurement object 10. As an example, the measurement device 100 generates tomographic images of different regions of the human body.

[0181] Furthermore, the determination unit 230 determines a part where a clearer magnetic resonance image should be measured. As an example, a part where a clearer image should be obtained is determined based on a plurality of tomographic images of a human body. Figure 8 The operation flow from S820 to S840 is to measure the magnetic resonance image. In addition, by further performing Figure 8 The operation flow from S850 to S890 can also be used to measure the state of the part determined based on the magnetic resonance image. It should be noted that, instead of the operations from S860 to S890, the frequency of the alternating current applied to the subject 10 by the current applicator 510 can be swept to measure the state of the part determined based on the magnetic resonance image.

[0182] As described above, the measuring device 100 can identify the portion to be measured by magnetic resonance imaging by acquiring more tomographic images easily and quickly. Furthermore, the measuring device 100 can identify the portion to be measured using a clear magnetic resonance image.

[0183] In addition, with Figure 5 The detection device 400 described in Figure 9 Similar to the detection device 600 described in the above, the measuring device 100 of the third structural example can also be a device that functions by being added to an existing MR image measuring device that outputs a magnetic resonance image. Figure 9 The structure is roughly the same as the structure. In addition, Figure 10 As described in , this device applies a plurality of alternating currents to output an image of the interior of the measurement object 10 .

[0184] For example, multiple current applicators 510 are positioned around the object 10 to apply multiple alternating currents in multiple directions to a portion of the object 10. Multiple magnetic field detection elements 130 are positioned around the object 10 to detect the magnetic field generated by the application of the multiple alternating currents. The calculation unit 164 calculates the internal impedance distribution of the object 10 based on the detection results of the multiple magnetic field detection elements 130. Furthermore, the internal information output unit 566 generates and outputs an image representing information about the interior of the object 10 based on the calculated impedance distribution.

[0185] Furthermore, at least some of the multiple current applying units 510 may sweep the frequency of the alternating current applied to the measurement object 10. In this case, the calculation unit 164 calculates the frequency characteristics of the impedance corresponding to the frequency of the alternating current, and the internal information output unit 566 generates information indicating the internal state of the measurement object 10 based on the calculated frequency characteristics of the impedance.

[0186] As described above, the measurement device 100 of the third configuration example functions as a device combined with the MR image measurement device 300. Thus, the measurement device 100 can apply multiple alternating currents to the measurement object 10 to generate an image representing information about the interior of the measurement object 10. Furthermore, the identification unit 230 can identify a portion of the measurement object 10 where a magnetic resonance image should be measured by the MR image measurement device 300, based on the image of the interior of the measurement object 10 generated by the internal information output unit 566.

[0187] Furthermore, the identification unit 230 can identify the portion of the subject 10 to be measured by applying an alternating current to the current applicator 510 based on the magnetic resonance image generated by the MR image measurement device 300. By applying the alternating current to the identified portion, the measurement device 100 can measure the internal state. This allows for a measurement device 100 that can efficiently acquire images and conditions of the interior of the subject 10 while fully utilizing existing equipment.

[0188] While the third exemplary configuration of the measuring device 100 described above is described as being combined with a device that outputs clearer MR images, this is not limiting. The measuring device 100 may also be configured as a standalone device for acquiring tomographic images. For example, the measuring device 100 may include multiple current applicators 510, multiple magnetic field detection elements 130, a calculation unit 164, and an internal information output unit 566.

[0189] In this case, for example, multiple magnetic field detection elements 130 are provided around the measurement object 10, and at least a portion of the multiple current applying units 510 sweeps the frequency of the alternating current applied to the measurement object 10. Furthermore, the calculation unit 164 calculates the impedance of a portion of the measurement object 10 and the frequency characteristics of the impedance corresponding to the frequency of the alternating current based on the detection results of the multiple magnetic field detection elements 130. Thus, the internal information output unit 566 can generate an image based on the calculated impedance distribution and the internal state of the measurement object 10 based on the frequency characteristics of the impedance.

[0190] In other words, the measuring device 100 of the third structural example can measure both the internal image and the internal state of the measuring object 10 by applying an alternating current to the measuring object 10 without applying a magnetic field. It should be noted that this measuring device 100 may further include the carrying unit 140 and the moving unit 150 already described.

[0191] While the measurement device 100 of this embodiment described above applies an alternating current or the like to a living body, serving as the measurement target 10, to obtain information about the body's interior, the present invention is not limited thereto. The measurement device 100 can be used, for example, to search for a living body or to measure the vital activities of a living body. This measurement device 100 will be described below.

[0192] <Fourth Configuration Example of Measurement Device 100>

[0193] Figure 12 A fourth configuration example of the measurement device 100 according to this embodiment is shown together with a measurement object 10. The measurement device 100 of the fourth configuration example includes multiple current applicators 510, a magnetic field detection element 130, a calculation unit 164, and an internal information output unit 566. As described above, the measurement device 100 is preferably configured as a device independent of the device that outputs MR images. The measurement device 100 uses the underground, rubble, a building, and the like as the measurement object 10 to search for a living organism trapped within the measurement object 10.

[0194] The multiple current applying units 510 apply multiple alternating currents in multiple directions to a portion of the object 10 from multiple locations on the object 10 via electrode pairs. The magnetic field detecting element 130 detects the magnitude of the magnetic field generated from the portion of the object 10 in response to the multiple alternating currents. A plurality of magnetic field detecting elements 130 may be provided. The portion of the object 10 to which the alternating current is applied does not have to be a living organism. As long as a magnetic field is generated by electromagnetic induction, the magnetic field detecting element 130 can detect the magnitude of the generated magnetic field. Furthermore, if almost no magnetic field is generated in the portion to which the alternating current is applied, the amount of magnetic field detected by the magnetic field detecting element 130 is zero.

[0195] The calculation unit 164 calculates the impedance of a portion of the measurement object 10 based on the detection results of the magnetic field detection element 130. Furthermore, the internal information output unit 566 generates information containing the internal components of the measurement object 10 based on the calculated impedance. For example, the impedance value varies depending on the components of the portion to which the alternating current is applied, such as a living organism, soil, concrete, stone, or tree. Therefore, even if a person is trapped underground, in rubble, or in a building due to a disaster and cannot visually confirm the measurement object 10 from the outside, it is still possible to determine whether a living organism exists within the measurement object 10.

[0196] The measuring device 100 of the fourth configuration example preferably applies alternating current to multiple portions of the measurement object 10 to determine the presence of a living organism in these portions. In this case, the measuring device 100 preferably measures the impedance distribution of a predetermined region of the measurement object 10 and determines the impedance range corresponding to the living organism. Thus, since the measuring device 100 can generate an image of the predetermined region corresponding to the impedance distribution, a user can visually confirm the size and general shape of the living organism within the measurement object 10, thereby determining the presence of a human, other animal, or plant.

[0197] Furthermore, the measurement device 100 can also perform simultaneous measurements by comparing impedances within the object 10. For example, the current application unit 510 applies multiple alternating currents to a first portion and a second portion of the object 10. Furthermore, the calculation unit 164 calculates a first impedance based on the detection results of the magnetic field generated from the first portion of the object 10 in response to the multiple alternating currents, and a second impedance based on the detection results of the magnetic field generated from the second portion of the object 10 in response to the multiple alternating currents. The internal information output unit 566 compares the calculated first impedance with the second impedance to generate information containing components of at least one of the first portion and the second portion.

[0198] In this case, the calculation unit 164 may calculate the absolute value of the impedance of a portion of the measurement object 10, or may calculate the relative value of the impedance instead of, or in addition to, calculating the absolute value of the impedance. Thus, even when the calculation unit 164 calculates the relative value of the impedance, for example, when the measurement device 100 measures a second portion after measuring a first portion, it can confirm whether the second portion has the same composition as the first portion. Furthermore, the user of the measurement device 100 can refer to the comparison result between the second portion and the first portion to determine the third portion to be measured next.

[0199] It should be noted that at least some of the multiple current applying units 510 may also sweep the frequency of the alternating current applied to the measurement object 10. The calculation unit 164 calculates the frequency characteristics of the impedance of the portion of the measurement object 10 based on the detection results of the magnetic field detection element 130. As a result, the internal information output unit 566 can obtain the spectral distribution of the induced magnetic field generated in the portion of the measurement object 10, and thus can more accurately generate information on the components in the portion of the measurement object 10.

[0200] Furthermore, the measuring device 100 of the fourth configuration example can also measure the temporal change in the impedance of a portion of the measuring object 10. In this case, the current applying unit 510 continuously applies multiple alternating currents to at least a portion of the measuring object 10 for a predetermined period. The magnetic field detecting element 130 detects the temporal change in the magnitude of the magnetic field generated in the portion of the measuring object 10. The calculating unit 164 calculates the impedance of the portion of the measuring object 10 multiple times during the predetermined period and outputs the temporal change in the impedance.

[0201] For example, even if a person trapped underground, in rubble, or in a building is unable to move freely, as long as they are still alive, they can still carry out vital activities such as breathing. Therefore, the temporal changes in the impedance of the measurement object 10 correspond to the changes associated with these vital activities. For example, if the position of organs associated with breathing, the person's movement, or the position of rubble associated with human movement occur in the area where the AC current is applied, the impedance will change over time.

[0202] The internal information output unit 566 generates information including internal components of the object 10 based on the temporal change in the impedance of a portion of the object 10. For example, the internal information output unit 566 outputs information indicating that the living body is moving in response to the temporal change in the impedance. Alternatively, the internal information output unit 566 may output information indicating that a component corresponding to the impedance has changed over time.

[0203] Furthermore, when applying alternating current to multiple parts of the measurement object 10 and measuring the impedance changes in the multiple parts over time, the internal information output unit 566 can also convert the impedance changes in the multiple parts into an image or the like and output it. This allows the user of the measurement device 100 to determine whether a person, animal, or the like is carrying out life activities within the measurement object 10.

[0204] The measuring device 100 of the fourth structural example described above can also be formed as a device housed in a single housing. In this case, the measuring device 100 can be provided with wheels, etc., which can be moved on the ground, etc. In this case, the measuring device 100 can also be formed in a manner that allows it to move autonomously. In addition, the portion of the measuring device 100 including at least the current applying unit 510 and the magnetic field detecting element 130 can also be formed in a manner that is separate from the device body. In this way, it is preferable that the measuring device 100 of the fourth structural example is formed so as to be able to perform measurements while moving to multiple locations on the ground, rubble, etc. in the wild.

[0205] As described above, the present invention has been described using embodiments. However, the technical scope of the present invention is not limited to the scope described in the above embodiments, and various modifications and variations can be made within the scope of its main purpose. For example, all or part of the device can be functionally or physically distributed or integrated in any unit. In addition, new embodiments generated by any combination of multiple embodiments are also included in the embodiments of the present invention. The effects of the new embodiments generated by the combination also have the effects of the original embodiments.

[0206] Description of Reference Numerals

[0207] 10 Measurement Objects

[0208] 100 Measuring device

[0209] 110 static magnetic field application unit

[0210] 120 deflection magnetic field applying unit

[0211] 130 magnetic field detection element

[0212] 140 Carrying unit

[0213] 150 Mobile Department

[0214] 160 Control Department

[0215] 162 Storage Department

[0216] 164 Computing Department

[0217] 166 Image information output unit

[0218] 170 Display unit

[0219] 210 Relaxation detection element

[0220] 220 MR image generation unit

[0221] 230 Determination Department

[0222] 300 MR imaging device

[0223] 310 Control Department

[0224] 400 Detection Device

[0225] 510 current applying unit

[0226] 566 Internal Information Output Department

[0227] 600 Detection Device

Claims

1. A measuring device, wherein: The measuring device comprises: a static magnetic field applying unit configured to apply a static magnetic field having a constant magnitude in a first direction to the measurement object; a plurality of current applying units configured to apply a plurality of alternating currents in a plurality of directions to a portion of the measurement object via electrode pairs; a magnetic field detection element that detects the magnitude of a magnetic field of an electromagnetic wave generated by nuclear magnetic resonance in a portion of the measurement object based on a static magnetic field having a constant magnitude in the first direction and the plurality of alternating currents, the magnitude of the magnetic field corresponding to the impedance of the measurement object; a calculation unit that calculates the impedance of a portion of the measurement object by analyzing the magnitude of the magnetic field detected by the magnetic field detection element; an internal information output unit that generates information including components inside the measurement object based on the calculated impedance; a deflection magnetic field applying unit configured to apply a deflection magnetic field having a predetermined frequency and in a second direction different from the first direction to a portion of the measurement object via a coil; a relaxation detection element that detects a relaxation phenomenon of an electromagnetic wave based on a deflection magnetic field generated in a portion of the measurement object by the deflection magnetic field applying unit; and An MR image generating unit generates and outputs a magnetic resonance image as a tomographic image of the interior of the measurement object based on the detection result of the relaxation detection element.

2. The measuring device according to claim 1, wherein The current applying unit applies the plurality of alternating currents to the first and second parts of the measurement object. The calculation unit calculates a first impedance based on a detection result of a magnetic field generated from the first portion of the measurement object in response to the plurality of alternating currents, and a second impedance based on a detection result of a magnetic field generated from the second portion of the measurement object in response to the plurality of alternating currents. The internal information output unit generates information including components of at least one of the first portion and the second portion by comparing the calculated first impedance with the second impedance.

3. The measuring device according to claim 1, wherein The current applying unit continuously applies the plurality of alternating currents to at least a portion of the measurement object for a predetermined period. The calculation unit calculates the impedance of a portion of the measurement object a plurality of times during the predetermined period. The internal information output unit generates information including components inside the measurement object based on a temporal change in impedance of a portion of the measurement object.

4. The measuring device according to claim 1, wherein The magnetic field detection element is provided in plurality around the measurement object. At least a portion of the plurality of current applying units sweeps the frequency of the alternating current applied to the measurement object, The calculation unit calculates the impedance of a portion of the measurement object and the frequency characteristics of the impedance corresponding to the frequency of the alternating current based on the detection results of the plurality of magnetic field detection elements. The internal information output unit generates information including an internal state of the measurement object based on the calculated frequency characteristics of the impedance.

5. The measuring device according to claim 1, wherein The measuring device further comprises: a carrying portion having a ring shape or a part of a ring shape surrounding the measurement object and carrying a plurality of the current applying portions; and A moving section moves the carrying section in a predetermined direction while maintaining the direction of the alternating current generated by the plurality of current applying sections relative to the measurement object.

6. The measuring device according to claim 5, wherein The mounting portion mounts one or more magnetic field detection elements.

7. The measuring device according to claim 1, wherein The measurement device further includes a specifying unit that specifies a site in the measurement object to which the alternating current should be applied by the current applicator and measured, based on the magnetic resonance image generated by the MR image generating unit.

8. The measuring device according to claim 7, wherein The internal information output unit further generates an image of the interior of the measurement object based on the calculated impedance. The specifying unit specifies a portion of the measurement object where the magnetic resonance image should be measured, based on the image of the interior of the measurement object generated by the internal information output unit.

9. The measuring device according to any one of claims 4 to 6, wherein: The internal information output unit further generates an image of the interior of the measurement object based on the calculated impedance. The measurement device further includes a specifying unit that specifies a portion of the measurement object to which the alternating current should be applied by the current applying unit and a state to be observed, based on the image of the interior of the measurement object generated by the internal information output unit.

10. A measuring device, wherein: The measuring device is provided with an MR image measuring device, and the MR image measuring device comprises: a static magnetic field applying unit configured to apply a static magnetic field having a constant magnitude in a first direction to the measurement object; a deflection magnetic field applying unit configured to apply a deflection magnetic field having a predetermined frequency and in a second direction different from the first direction to a portion of the measurement object via a coil; a relaxation detection element that detects electromagnetic waves generated in a portion of the measurement object due to application of a deflection magnetic field and a relaxation phenomenon of the generated electromagnetic waves; and an MR image generating unit that generates and outputs a magnetic resonance image as a tomographic image of the interior of the measurement object based on the detection result of the relaxation detection element, The measuring device comprises: the static magnetic field applying part; a plurality of current applying units configured to apply a plurality of alternating currents in a plurality of directions to a portion of the measurement object via electrode pairs; a magnetic field detection element that detects the magnitude of a magnetic field of an electromagnetic wave generated by nuclear magnetic resonance in a portion of the measurement object based on a static magnetic field having a constant magnitude in the first direction and the plurality of alternating currents, the magnitude of the magnetic field corresponding to the impedance of the measurement object; a calculation unit that calculates the impedance of a portion of the measurement object by analyzing the magnitude of the magnetic field detected by the magnetic field detection element; an internal information output unit that generates information including components inside the measurement object based on the calculated impedance, wherein at least a portion of the plurality of current applying units sweeps the frequency of the alternating current applied to the measurement object; The calculation unit calculates the frequency characteristics of the impedance corresponding to the frequency of the AC current. The internal information output unit generates information indicating an internal state of the measurement object based on the calculated frequency characteristics of the impedance.

11. The measuring device according to claim 10, wherein The measurement device further includes a specifying unit that specifies a site in the measurement object to which the alternating current should be applied by the current applying unit, based on the magnetic resonance image generated by the MR image generating unit.

12. The measuring device according to claim 11, wherein The internal information output unit further generates an image of the interior of the measurement object based on the calculated impedance. The specifying unit specifies a portion of the measurement object where the magnetic resonance image should be measured, based on the image of the interior of the measurement object generated by the internal information output unit.

13. A determination method, wherein: The determination method comprises the following steps: applying a static magnetic field of a constant magnitude in a first direction to the measurement object; applying a plurality of alternating currents in a plurality of directions to a portion of the measurement object via an electrode pair; detecting the magnitude of the magnetic field of an electromagnetic wave generated by nuclear magnetic resonance in a portion of the measurement object based on the static magnetic field having a constant magnitude in the first direction and the plurality of alternating currents, wherein the magnitude of the magnetic field corresponds to the impedance of the measurement object; calculating the impedance of a portion of the measurement object by analyzing the magnitude of the detected magnetic field; generating and outputting information indicating components inside the measurement object based on the calculated impedance; applying a deflection magnetic field having a predetermined frequency and a second direction different from the first direction to a portion of the measurement object via a coil; detecting a relaxation phenomenon of electromagnetic waves caused by a deflection magnetic field in a portion of the measurement object; as well as Based on the detection results of the relaxation detection element, a magnetic resonance image is generated and output as a tomographic image of the interior of the measurement object.

14. The assay method according to claim 13, wherein The step of applying the plurality of alternating currents includes the steps of: sweeping the frequency of at least a portion of the plurality of alternating currents applied to the measurement object; The step of detecting the magnitude of the magnetic field generated from a portion of the measurement object includes the steps of: detecting the magnitude of the magnetic field generated from a portion of the measurement object in response to a plurality of the alternating currents at a plurality of locations around the measurement object, respectively; The step of calculating the impedance of a portion of the measurement object includes the steps of: calculating a frequency characteristic of the impedance corresponding to the frequency of the alternating current; The step of generating information indicating the internal state of the measurement object includes the step of generating information including the internal state of the measurement object based on the calculated frequency characteristics of the impedance.

15. A determination method, wherein: The determination method comprises the following steps: applying a static magnetic field of a constant magnitude in a first direction to the measurement object; applying a plurality of alternating currents in a plurality of directions to a portion of the measurement object via an electrode pair; detecting the magnitude of the magnetic field of an electromagnetic wave generated by nuclear magnetic resonance in a portion of the measurement object based on the static magnetic field having a constant magnitude in the first direction and the plurality of alternating currents, wherein the magnitude of the magnetic field corresponds to the impedance of the measurement object; calculating the impedance of a portion of the measurement object by analyzing the magnitude of the detected magnetic field; generating and outputting information indicating components inside the measurement object based on the calculated impedance; applying a deflection magnetic field having a predetermined frequency and a second direction different from the first direction to a portion of the measurement object via a coil; detecting electromagnetic waves generated in a portion of the measurement object due to application of the deflection magnetic field and a relaxation phenomenon of the generated electromagnetic waves; as well as generating and outputting a magnetic resonance image as a tomographic image of the interior of the measurement object based on the electromagnetic waves generated by applying the deflection magnetic field and the detection result of the relaxation phenomenon of the generated electromagnetic waves; In the step of applying a plurality of the alternating currents, at least a portion of the plurality of the alternating currents sweeps the frequency of the alternating current applied to the measurement object. In the step of calculating the impedance of a portion of the measurement object, a frequency characteristic of the impedance corresponding to the frequency of the alternating current is calculated. In the step of generating and outputting information indicating components inside the measurement object, information indicating a state inside the measurement object is generated based on the calculated frequency characteristics of the impedance.

Images