Heating needle temperature calibration method and calibration device

Abstract

The application discloses a heating needle temperature calibration method and a calibration device. First, the heating needle absorbs liquid and heats the liquid to a preset temperature, then the heating needle injects the liquid into the calibration device for the first time, the calibration device is heated to make the temperature of the liquid in the calibration device reach the preset value, and then the heating needle injects the same liquid into the calibration device for the nth time. The calibration device can adjust the preset temperature of the heating needle according to the difference between the liquid temperature and the preset value, so that the heating temperature of the reagent in the heating needle is ensured to be within a normal range. The preset temperature of the heating needle can be effectively calibrated through the heating needle temperature calibration method, so that the heating performance of the heating needle on the reagent in the refrigerated reagent bin is ensured, the reagent is added into a reaction cup of a sample analyzer after being heated to the adjusted preset temperature, the reaction effect is ensured, and then the accuracy and high efficiency of the test result of the sample analyzer are ensured.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of coagulation analyzer quality detection, and particularly relates to a heating needle temperature calibration method and a calibration device. BACKGROUND

[0002] A full-automatic coagulation analyzer is closely related to various clinical diseases in terms of hemostasis and detection indexes of thrombus molecular markers. A reagent needle is an important component of the full-automatic coagulation analyzer, is used to suck reagents, and needs to heat and maintain the reagents in the needle at a preset temperature to ensure the accuracy of test results.

[0003] The existing reagent needle generally winds a heating piece on a needle tube to heat the needle tube and the reagents, and then directly measures the heating piece by using a temperature sensor to determine the temperature of the reagents. However, the heating performance of the reagent needle will generally decrease after being used for a period of time, so that the heating temperature of the reagents in the reagent needle deviates from the normal range, resulting in errors in the measurement results of the full-automatic coagulation analyzer.

[0004] Therefore, it is necessary to provide a new heating needle temperature calibration method and a calibration device to solve the above technical problems. SUMMARY

[0005] The main purpose of the present application is to provide a heating needle temperature calibration method and a calibration device, which aims to solve the problem of how to ensure that the heating temperature of the reagents in the reagent needle is within the normal range.

[0006] To achieve the above purpose, the heating needle temperature calibration method provided by the present application comprises the following steps:

[0007] sucking liquid by the heating needle and heating the liquid to a preset temperature T0;

[0008] first injecting the liquid into the calibration device by the heating needle; and heating the calibration device to make the temperature of the liquid in the calibration device reach a preset value.

[0009] injecting the liquid into the calibration device by the heating needle for the nth time, where n is greater than or equal to 2; and adjusting the preset temperature of the heating needle according to the difference between the temperature of the liquid and the preset value by the calibration device.

[0010] Optionally, the step of injecting the liquid into the calibration device by the heating needle for the nth time, where n is greater than or equal to 2; and adjusting the preset temperature of the heating needle according to the difference between the temperature of the liquid and the preset value by the calibration device comprises the following steps:

[0011] When the heating needle injects the liquid into the calibration device for the second time, the difference between the liquid temperature in the calibration device and the preset value is △T1, and the preset temperature of the heating needle is adjusted to T0+△T1 by the calibration device;

[0012] When the heating needle injects the liquid into the calibration device for the third time, the liquid in the calibration device is heated to the preset value by controlling the calibration device;

[0013] When the heating needle injects the liquid into the calibration device for the fourth time, the difference between the liquid temperature in the calibration device and the preset value is △T2, and the preset temperature of the heating needle is adjusted to T0+△T1*△T2*(△T2-△T1) by the calibration device.

[0014] Optionally, after the step of when the heating needle injects the liquid into the calibration device for the fourth time, the difference between the liquid temperature in the calibration device and the preset value is △T2, and the preset temperature of the heating needle is adjusted to T0+△T1*△T2*(△T2-△T1) by the calibration device, the method further comprises:

[0015] When the heating needle injects the liquid into the calibration device for the fifth time, the liquid in the calibration device is heated to the preset value by controlling the calibration device;

[0016] When the heating needle injects the liquid into the calibration device for the sixth time, the difference between the liquid temperature in the calibration device and the preset value is △T3, and △T3 is compared with a preset threshold value:

[0017] If △T3 is less than the preset threshold value, the calibration of the heating needle is successful;

[0018] If △T3 is greater than the preset threshold value, the above steps are repeated for N times, and if △T3 of the Nth time is still greater than the preset threshold value, the calibration of the heating needle fails, wherein N≤3.

[0019] Optionally, before the step of the heating needle sucking the liquid and heating the liquid to a preset temperature T0, the method further comprises:

[0020] injecting the liquid into the calibration device by the heating needle;

[0021] heating the liquid to a preset value by controlling the calibration device to heat;

[0022] obtaining the liquid temperature in the calibration device as a detection value by an external temperature sensor;

[0023] eliminating the difference between the detection value and the preset value by adjusting the heating parameter of the calibration device.

[0024] In addition, the application further provides a calibration device applied to the heating needle temperature calibration method, the calibration device comprising a calibration pool, a heating assembly and a temperature control assembly, one side of the calibration pool is concave to form a cavity with a liquid inlet, the cavity is used for containing liquid injected by a heating needle, the heating needle is used for heating the liquid to a preset temperature; the heating assembly is connected with the calibration pool and is used for heating the calibration pool; the temperature control assembly comprises a first temperature sensor, a second temperature sensor and a controller, the first temperature sensor is connected with the calibration pool and is used for detecting the temperature of the calibration pool; the second temperature sensor is arranged in the cavity and is used for detecting the temperature of the liquid in the cavity; the heating assembly, the first temperature sensor, the second temperature sensor and the heating needle are in communication connection with the controller, when the heating needle injects the liquid into the cavity for the first time, the controller is used for controlling the heating assembly to heat the calibration pool according to the temperature of the liquid in the cavity until the temperature of the liquid in the cavity reaches a preset value, when the heating needle injects the liquid into the cavity for the nth time, the controller is further used for adjusting the preset temperature of the heating needle according to the difference between the temperature of the liquid in the cavity and the preset value, wherein n≥2.

[0025] Optionally, the heating assembly comprises a connecting line and a heating film, the heating film is in communication connection with the controller through the connecting line, the heating film surrounds the outer periphery of the calibration pool and is used for heating the calibration pool.

[0026] Optionally, the calibration device further comprises a temperature protection switch, the temperature protection switch is in communication connection with the controller, and the controller is further used for controlling the temperature protection switch to be turned off when the temperature of the calibration pool reaches a safety temperature, so that the heating film stops heating the calibration pool.

[0027] Optionally, the calibration device further comprises a heat preservation layer, the heat preservation layer surrounds the outer periphery of the heating film.

[0028] Optionally, the cavity further has a liquid outlet, the liquid outlet is located at the bottom of the calibration pool.

[0029] Optionally, the first temperature sensor is arranged at the bottom of the calibration pool, the second temperature sensor is inserted into the cavity from the side wall of the calibration pool and is arranged close to the cavity bottom wall.

[0030] In the technical scheme, when the temperature performance of the heating needle needs to be adjusted, the heating needle first absorbs liquid and heats the liquid to a preset temperature of the heating needle, then the heating needle first injects the liquid into the cavity of the calibration pool, the controller controls the heating assembly to heat the calibration pool according to the liquid temperature in the cavity, so that the liquid temperature in the cavity reaches a preset value, and then the heating needle injects the same liquid into the cavity of the calibration pool for the nth time, and the controller adjusts the preset temperature of the heating needle according to the difference between the liquid temperature in the cavity and the preset value, so as to ensure that the heating temperature of the reagent in the heating needle is within a normal range. Therefore, in the above technical scheme, the preset temperature of the heating needle can be effectively calibrated by the heating needle temperature calibration method, so as to ensure the heating performance of the heating needle on the reagent in the refrigerated reagent bin, so that the heated reagent can be maintained within a normal range, and when the reagent is heated to the adjusted preset temperature, the reagent is added to the reaction cup of the sample analyzer, so as to ensure the reaction effect, and further ensure the accuracy and efficiency of the test result of the sample analyzer. BRIEF DESCRIPTION OF DRAWINGS

[0031] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of the drawings shown.

[0032] Figure 1 The flowchart of the heating needle temperature calibration method in an embodiment of the present application is shown.

[0033] Figure 2 The detailed flowchart of step S30 in an embodiment of the present application is shown.

[0034] Figure 3 The flowchart before step S10 in an embodiment of the present application is shown.

[0035] Figure 4 The structure diagram of the calibration device in an embodiment of the present application is shown.

[0036] Figure 5 The sectional view diagram of the calibration device in an embodiment of the present application is shown.

[0037] Explanation of reference numerals:

[0038] Reference Name Reference Name 100 Calibration device 21 Heating film 10 Calibration cell 30 Temperature control assembly 11 Liquid inlet 31 First temperature sensor 12 Cavity 32 Second temperature sensor 13 Liquid outlet 40 Temperature protection switch 20 Heating assembly 50 Heat preservation layer

[0039] The implementation, functional features and advantages of the present application will be further described with reference to the embodiments and the accompanying drawings. DETAILED DESCRIPTION

[0040] With reference to the accompanying drawings, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by a person of ordinary skill in the art without creative effort are within the scope of the present application.

[0041] It should be noted that all the direction indications (such as up, down, left, right, front, back, and the like) in the embodiments of the present application are only used to explain the relative position relationship, movement condition and the like between components in a certain posture (as shown in the drawings), and if the certain posture changes, the direction indications also change accordingly.

[0042] In addition, the descriptions such as “first”, “second” and the like in the present application are only for the purpose of description, and cannot be understood as indicating or implying the relative importance of the indicated technical features or implicitly indicating the number of the indicated technical features. Therefore, the features defined as “first” and “second” can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of “plurality” is at least two, for example, two, three, and the like, unless otherwise specifically limited.

[0043] In the present application, unless otherwise specifically defined and limited, the terms “connection”, “fixation” and the like should be understood in a broad sense, for example, “fixation” can be fixed connection, or detachable connection, or integral; can be mechanical connection, or electrical connection; can be direct connection, or indirect connection through an intermediate medium; can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise specifically defined. For a person of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0044] In addition, the technical solutions of each embodiment of the present application can be combined with each other, but it must be based on the fact that a person of ordinary skill in the art can realize it, and when the combination of technical solutions appears contradictory or unachievable, it should be considered that the combination of technical solutions does not exist, and is not within the scope of protection required by the present application.

[0045] The present application provides a heating needle temperature calibration device and a calibration method, aiming to solve the problem of how to ensure that the reagent heating temperature in the reagent needle is within a normal range.

[0046] As shown in the figure, in an embodiment of the present application, the heating needle temperature calibration method comprises: Figure 1

[0047] S10, absorbing liquid by the heating needle and heating the liquid to a preset temperature T0;

[0048] ​S20, injecting liquid into the calibration device 100 for the first time through the heating needle; heating the calibration device 100 to make the temperature of the liquid in the calibration device 100 reach the preset value;

[0049] S30, injecting liquid into the calibration device 100 for the nth time through the heating needle, where n≥2; adjusting the preset temperature of the heating needle by the calibration device 100 according to the difference between the temperature of the liquid and the preset value.

[0050] In the above embodiment, when the temperature performance of the heating needle needs to be adjusted, the liquid is first absorbed by the heating needle and heated to the preset temperature T0 of the heating needle, then the liquid is injected into the calibration device 100 for the first time through the heating needle, the calibration device 100 is heated to make the temperature of the liquid in the calibration device 100 reach the preset value, and then the same liquid is injected into the calibration device 100 for the nth time through the heating needle. The calibration device 100 can adjust the preset temperature T0 of the heating needle according to the difference between the temperature of the liquid and the preset value, so as to ensure that the heating temperature of the reagent in the heating needle is within the normal range. Therefore, the heating needle temperature calibration method can effectively calibrate the preset temperature of the heating needle, so as to ensure the heating performance of the heating needle for the reagent in the refrigerated reagent bin, so that the heated reagent can be maintained within the normal range. When the reagent is heated to the adjusted preset temperature and then added to the reaction cup of the sample analyzer, the reaction effect is ensured, and the accuracy and efficiency of the test result of the sample analyzer are ensured.

[0051] Further, as shown in FIG. 3, S30 includes the following steps: Figure 2

[0052] S31, when the heating needle injects liquid into the calibration device 100 for the second time, the difference between the temperature of the liquid in the calibration device 100 and the preset value is △T1, and the preset temperature of the heating needle is adjusted by the calibration device 100 to T0+△T1;

[0053] S32, when the heating needle injects liquid into the calibration device 100 for the third time, the calibration device 100 is heated to make the temperature of the liquid in the calibration device 100 reach the preset value;

[0054] S33, when the heating needle injects liquid into the calibration device 100 for the fourth time, the difference between the temperature of the liquid in the calibration device 100 and the preset value is △T2, and the preset temperature of the heating needle is adjusted by the calibration device 100 to T0+△T1*△T2*(△T2-△T1).

[0055] ​Specifically, when the heating needle injects the liquid into the calibration device 100 for the second time, the liquid in the calibration device 100 at this time includes the liquid injected by the heating needle for the first time and the liquid injected for the second time, the temperature of the mixed liquid in the calibration device 100 at this time is obtained, the difference between the temperature of the mixed liquid in the calibration device 100 and the preset value is recorded as AT1, the preset temperature of the heating needle is automatically adjusted to TO+AT1 by controlling the calibration device 100, and then the mixed liquid in the calibration device 100 is discharged; then the liquid is injected into the calibration device 100 by the heating needle with the adjusted preset temperature for the third time, and the step of injecting the liquid into the calibration device 100 by the heating needle for the first time is repeated, so that the temperature of the liquid in the calibration device 100 reaches the preset value, when the heating needle injects the liquid into the calibration device 100 for the fourth time, the liquid in the calibration device 100 at this time includes the liquid injected by the heating needle for the third time and the liquid injected for the fourth time, the temperature of the mixed liquid in the calibration device 100 at this time is obtained, the difference between the temperature of the mixed liquid in the calibration device 100 and the preset value is recorded as AT2, the preset temperature of the heating needle is automatically adjusted to TO+AT1*AT2*(AT2-AT1) by controlling the calibration device 100, and then the mixed liquid in the calibration device 100 is discharged. In an ideal state, the temperature of the mixed liquid in the calibration device 100 should be consistent with the preset value.

[0056] Further, S33 further includes:

[0057] S34, when the heating needle injects the liquid into the calibration device 100 for the fifth time, the calibration device 100 is heated to make the temperature of the liquid in the calibration device 100 reach the preset value;

[0058] S35, when the heating needle injects the liquid into the calibration device 100 for the sixth time, the difference between the temperature of the liquid in the calibration device 100 and the preset value is AT3, and AT3 is compared with a preset threshold value;

[0059] Specifically, when the preset temperature of the heating needle is adjusted to TO+AT1*AT2*(AT2-AT1), the liquid is injected into the calibration device 100 by the heating needle with the adjusted preset temperature for the fifth time, the step of injecting the liquid into the calibration device 100 by the heating needle for the first time is repeated, so that the temperature of the liquid in the calibration device 100 reaches the preset value, and then the liquid is injected into the calibration device 100 by the heating needle for the sixth time, the liquid in the calibration device 100 at this time includes the liquid injected by the heating needle for the fifth time and the liquid injected for the sixth time, the temperature of the mixed liquid in the calibration device 100 at this time is obtained, the difference between the temperature of the mixed liquid in the calibration device 100 and the preset value is recorded as AT3, and AT3 is compared with a preset threshold value at this time:

[0060] If AT3 is less than the preset threshold value, the calibration of the heating needle is successful;

[0061] If △T3 is greater than the preset threshold value, the above steps of injecting liquid into the calibration device 100 by the heating needle for the first to sixth times are repeated for N times, and if △T3 of the Nth time is still greater than the preset threshold value, the calibration of the heating needle fails, wherein N≤3, and thus it is known that if △T3 of the third time is still greater than the preset threshold value, the calibration of the heating needle fails. In actual operation, the preset threshold value is 0.5.

[0062] In an embodiment, as shown in FIG. 1, S10 further includes the following steps before S10: Figure 3

[0063] S01, injecting liquid into the calibration device 100 by the heating needle;

[0064] S02, heating the liquid to a preset value by controlling the calibration device 100 to heat;

[0065] S03, obtaining the liquid temperature in the calibration device 100 as a detection value by the external temperature sensor;

[0066] S04, adjusting the heating parameter of the calibration device 100 to eliminate the difference between the detection value and the preset value.

[0067] In the embodiment, first, liquid is injected into the cavity 12 of the calibration pool 10 by the heating needle so that the liquid level is higher than the second temperature sensor 32, and then the controller controls the heating assembly 20 to heat the calibration pool 10 according to the temperature of the calibration pool 10, so that the sensing temperature of the first sensor is a preset value. The liquid temperature in the cavity 12 is obtained as a detection value by the external temperature sensor, and then the heating parameter of the heating assembly 20 is adjusted by the controller to eliminate the difference between the detection value and the preset value, so as to eliminate the sensing error of the first temperature sensor 31. At this time, the sensing temperature of the second temperature sensor 32 is recorded, and the difference between the sensing temperature of the second temperature sensor 32 and the preset value is the calibration difference value, and the calibration difference value is recorded, thereby completing the calibration of the first temperature sensor 31 and the second temperature sensor 32. When calibrating the preset temperature of the heating needle, liquid is injected into the cavity 12 by the heating needle for the first time; the heating assembly 20 is controlled by the controller according to the liquid temperature in the cavity 12 to heat the calibration pool 10, so that the liquid temperature in the cavity 12 reaches the preset value, that is, the sum of the sensing temperature of the second sensor and the calibration difference value is the preset value. In the preferred embodiment, the external temperature sensor can be a high-precision K-type thermocouple, which has the advantages of fast response, wide temperature range, good stability and uniformity, and ensures the accuracy of measuring the liquid temperature in the cavity 12.

[0068] In addition, as shown in FIG. 1 and FIG. 2, Figure 4 and Figure 5 ​As shown, the present application also provides a calibration device 100, which is applied to the heating needle temperature calibration method as described above, and the calibration device 100 comprises a calibration pool 10, a heating assembly 20 and a temperature control assembly 30. The calibration pool 10 is concave on one side to form a cavity 12 with a liquid inlet 11, and the cavity 12 is used to hold the liquid injected by the heating needle, and the heating needle is used to heat the liquid to a preset temperature. The heating assembly 20 is connected with the calibration pool 10 and is used to heat the calibration pool 10. The temperature control assembly 30 comprises a first temperature sensor 31, a second temperature sensor 32 and a controller. The first temperature sensor 31 is connected with the calibration pool 10 and is used to detect the temperature of the calibration pool 10. The second temperature sensor 32 is arranged in the cavity 12 and is used to detect the temperature of the liquid in the cavity 12. The heating assembly 20, the first temperature sensor 31, the second temperature sensor 32 and the heating needle are all in communication connection with the controller. When the heating needle injects the liquid into the cavity 12 for the first time, the controller is used to control the heating assembly 20 to heat the calibration pool 10 according to the temperature of the liquid in the cavity 12 until the temperature of the liquid in the cavity 12 reaches the preset value. When the heating needle injects the liquid into the cavity 12 for the nth time, the controller is also used to adjust the preset temperature of the heating needle according to the difference between the temperature of the liquid in the cavity 12 and the preset value, wherein n≥2.

[0069] In the above embodiment, when it is necessary to adjust the temperature performance of the heating needle, the liquid is first sucked by the heating needle and heated to the preset temperature of the heating needle, and then the liquid is injected into the cavity 12 of the calibration pool 10 for the first time by the heating needle. The controller controls the heating assembly 20 to heat the calibration pool 10 according to the temperature of the liquid in the cavity 12, so that the temperature of the liquid in the cavity 12 reaches the preset value. Then the same liquid is injected into the cavity 12 of the calibration pool 10 for the nth time by the heating needle. The controller can adjust the preset temperature of the heating needle according to the difference between the temperature of the liquid in the cavity 12 and the preset value, so as to ensure that the heating temperature of the reagent in the heating needle is within the normal range. Thus, the preset temperature of the heating needle can be automatically calibrated by the calibration device 100, so as to ensure the heating performance of the heating needle on the reagent in the refrigerated reagent bin, so that the heated reagent can be maintained within the normal range. When the reagent is heated to the adjusted preset temperature and then added to the reaction cup of the sample analyzer, the reaction effect is ensured, and thus the accuracy and efficiency of the test result of the sample analyzer are ensured.

[0070] In actual use, the first temperature sensor 31 and the second temperature sensor 32 will have a fixed deviation between the sensed temperature and the actual temperature value during installation and the process in which the controller controls the heating film 21 to heat the calibration pool 10. Therefore, before calibrating the preset temperature of the heating needle, the first temperature sensor 31 and the second temperature sensor 32 need to be calibrated to ensure the accuracy of the temperature detected by the first temperature sensor 31 and the second temperature sensor 32, thereby reducing the error rate of calibrating the preset temperature of the heating needle and improving the calibration efficiency.

[0071] Since the calibration device 100 is applied to the heating needle temperature calibration method as described above, the calibration device 100 has all the beneficial effects of the heating needle temperature calibration method described above, which will not be repeated here.

[0072] In actual application, the sample analyzer is equipped with a heating needle, which is used to transfer the reagent to be tested from the storage position to the test position. In order to ensure the activity of the reagent to be tested, the reagent needs to be refrigerated and stored in the storage position, and the temperature is between 10℃ and 120℃. However, during testing, the reagent temperature generally needs to reach about 37℃ to ensure the accuracy of the test results. Therefore, after the reagent is sucked by the heating needle, the reagent in the needle needs to be heated to a preset temperature to ensure the accuracy and consistency of the test results. When adjusting the temperature performance of the heating needle, the liquid sucked by the heating needle can be cleaning liquid or deionized water. The cleaning liquid is injected into the cavity 12 of the calibration pool 10 through the heating needle, and at the same time, the cavity 12 can be cleaned, which can quickly and effectively remove various stains and dirt. Deionized water refers to pure water from which ionic impurities have been removed, making the water purer.

[0073] The heating assembly 20 includes a connecting line and a heating film 21. The heating film 21 is in communication connection with the controller through the connecting line. The heating film 21 is arranged around the outer periphery of the calibration pool 10 and is used to heat the calibration pool 10. Specifically, the controller is used to receive the signal sent by the second temperature sensor 32 and output a heating signal to the heating film 21 through the connecting line to control the heating film 21 to heat the calibration pool 10. By arranging the heating film 21 around the outer periphery of the calibration pool 10, the calibration pool 10 can be uniformly heated as a whole, so that the liquid in the cavity 12 can be heated to a preset value.

[0074] In an embodiment, the calibration device 100 further comprises a temperature protection switch 40, which is in communication connection with the controller. Specifically, when the heating film 21 heats the calibration pool 10, the controller controls the temperature protection switch 40 to be turned off to stop the heating film 21 from heating the calibration pool 10 when an abnormality occurs during the heating process or when the temperature of the calibration pool 10 reaches a safety temperature, thereby improving the safety during the heating process of the calibration pool 10. Meanwhile, the temperature protection switch 40 has the advantages of stable performance, easy installation and long service life.

[0075] Further, the calibration device 100 further comprises an insulation layer 50, which surrounds the outer periphery of the heating film 21. The insulation layer 50 can reduce the loss of heat diffusion of the heating film 21 to the outside, so that the temperature of the liquid in the cavity 12 is consistent with the heating temperature of the heating film 21 as much as possible, thereby stabilizing the temperature of the liquid in the cavity 12, keeping the temperature of the liquid in the cavity 12 at around the preset value at all times, maintaining dynamic balance, improving the accuracy of the measurement results of the second temperature sensor 32, and improving the heating efficiency of the heating film 21, thereby improving the calibration efficiency of the calibration device 100 in calibrating the preset temperature of the heating needle.

[0076] Further, the cavity 12 further has a liquid discharge port 13 located at the bottom of the calibration pool 10. When the heating needle injects liquid into the cavity 12 of the calibration pool 10 for the nth time, the controller can adjust the preset temperature of the heating needle according to the difference between the temperature of the liquid in the cavity 12 and the preset value. Before the heating needle with the adjusted preset temperature injects the same liquid into the cavity 12 of the calibration pool 10 for the nth+1 time, the waste liquid in the cavity 12 needs to be discharged from the calibration pool 10 through the liquid discharge port 13, thereby facilitating the judgment of whether the temperature performance of the heating needle after adjusting the preset temperature is within the normal range, and improving the accuracy and efficiency of the calibration process.

[0077] Specifically, the first temperature sensor 31 is arranged at the bottom of the calibration pool 10, and the heating film 21 surrounds the outer periphery of the calibration pool 10 while leaving a detection position of the calibration pool 10 for the first temperature sensor 31 to detect the temperature of the calibration pool 10. The second temperature sensor 32 is inserted into the cavity 12 from the side wall of the calibration pool 10 and is arranged close to the bottom wall of the cavity 12. The second temperature sensor 32 is used to detect the temperature of the liquid in the cavity 12, and the liquid in the cavity 12 needs to cover the second sensor, thereby further improving the accuracy of the measurement results of the second temperature sensor 32. Both the first temperature sensor 31 and the second temperature sensor 32 can sense the temperature and convert it into a usable output signal. The arrangement of two temperature sensors for measuring the temperature of the calibration pool 10 and the temperature of the liquid in the cavity 12 respectively is conducive to improving the efficiency of temperature detection. The temperature sensor has the advantages of small measurement error, fast response speed and long service life.

[0078] The above merely describes the preferred embodiments of the present application, and is not intended to limit the patent scope of the present application. Any equivalent structural transformation, direct / indirect application in other related technical fields, or the like, made under the inventive concept of the present application, using the content of the present application specification and drawings, are included in the patent protection scope of the present application.

Claims

1. A heating needle temperature calibration method, characterized by, Comprising: absorbing liquid by the heating needle and heating the liquid to a preset temperature T0; injecting the liquid into the calibration device for the first time by the heating needle; heating the calibration device to make the temperature of the liquid in the calibration device reach a preset value; injecting the liquid into the calibration device for the n-th time by the heating needle, where n≥2; adjusting the preset temperature of the heating needle by the calibration device according to the difference between the temperature of the liquid and the preset value; the step of injecting the liquid into the calibration device for the n-th time by the heating needle, where n≥2; adjusting the preset temperature of the heating needle by the calibration device according to the difference between the temperature of the liquid and the preset value comprises: when the heating needle injects the liquid into the calibration device for the second time, the difference between the temperature of the liquid in the calibration device and the preset value is △T1, the preset temperature of the heating needle is adjusted by the calibration device to T0+△T1, and then the mixed liquid in the calibration device is discharged; when the heating needle injects the liquid into the calibration device for the third time, the calibration device is controlled to heat to make the temperature of the liquid in the calibration device reach a preset value; when the heating needle injects the liquid into the calibration device for the fourth time, the difference between the temperature of the liquid in the calibration device and the preset value is △T2, the preset temperature of the heating needle is adjusted by the calibration device to T0+△T1*△T2*(△T2-△T1), and then the mixed liquid in the calibration device is discharged; the step of injecting the liquid into the calibration device for the fourth time by the heating needle, where n≥2; adjusting the preset temperature of the heating needle by the calibration device according to the difference between the temperature of the liquid and the preset value comprises: when the heating needle injects the liquid into the calibration device for the fifth time, the calibration device is controlled to heat to make the temperature of the liquid in the calibration device reach a preset value; when the heating needle injects the liquid into the calibration device for the sixth time, the difference between the temperature of the liquid in the calibration device and the preset value is △T3, and △T3 is compared with a preset threshold value: if △T3 is less than the preset threshold value, the calibration of the heating needle is successful; if △T3 is greater than the preset threshold value, the above steps are repeated for N times, and if △T3 of the N-th time is still greater than the preset threshold value, the calibration of the heating needle fails, where N≤3.

2. The heating needle temperature calibration method of claim 1, wherein, the step of absorbing liquid by the heating needle and heating the liquid to a preset temperature T0 further comprises: injecting the liquid into the calibration device by the heating needle; heating the calibration device to heat the temperature of the liquid to a preset value; obtaining the temperature of the liquid in the calibration device by an external temperature sensor as a detection value; adjusting the heating parameters of the calibration device to eliminate the difference between the detection value and the preset value.

3. A calibration device for use in the heating needle temperature calibration method according to any one of claims 1 to 2, characterized in that, Comprising: The calibration pool has a cavity with a liquid inlet on one side, which is used to hold the liquid injected by the heating needle, and the heating needle is used to heat the liquid to a preset temperature; The heating assembly is connected with the calibration pool and used to heat the calibration pool; The temperature control assembly includes a first temperature sensor, a second temperature sensor and a controller, the first temperature sensor is connected with the calibration pool and used to detect the temperature of the calibration pool, the second temperature sensor is arranged in the cavity and used to detect the temperature of the liquid in the cavity, the heating assembly, the first temperature sensor, the second temperature sensor and the heating needle are all connected with the controller, when the heating needle injects the liquid into the cavity for the first time, the controller is used to control the heating assembly to heat the calibration pool according to the temperature of the liquid in the cavity until the temperature of the liquid in the cavity reaches a preset value, when the heating needle injects the liquid into the cavity for the nth time, the controller is also used to adjust the preset temperature of the heating needle according to the difference between the temperature of the liquid in the cavity and the preset value, wherein n is greater than or equal to 2.

4. The calibration device of claim 3, wherein, The heating assembly includes a connecting line and a heating film, the heating film is connected with the controller through the connecting line, the heating film surrounds the outer periphery of the calibration pool and is used to heat the calibration pool.

5. The calibration device of claim 4, wherein, The calibration device further includes a temperature protection switch connected with the controller, and the controller is further used to control the temperature protection switch to be turned off when the temperature of the calibration pool reaches a safety temperature, so that the heating film stops heating the calibration pool.

6. The calibration device of claim 4, wherein, The calibration device further includes a heat preservation layer surrounding the outer periphery of the heating film.

7. The calibration device of any one of claims 3 to 6, characterized in that The cavity further has a liquid outlet at the bottom of the calibration pool.

8. The calibration device of any one of claims 3 to 6, wherein, The first temperature sensor is arranged at the bottom of the calibration pool, and the second temperature sensor is inserted into the cavity from the side wall of the calibration pool and arranged close to the cavity bottom wall.

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