A dual-continuous phase makeup remover for removing makeup and making up in one and a preparation method thereof

Abstract

The present invention relates to a dual-phase makeup remover and a preparation method thereof. The components of the dual-phase makeup remover and a preparation method thereof include: an emulsifier, a liquid oil, a polyol, a protease, an antioxidant and water. The present invention uses the emulsifier, the liquid oil, the polyol and water as main raw materials, so that the prepared dual-phase makeup remover has good stability, a refreshing skin feel, and has a good removal effect on both water-soluble and oil-soluble makeup. On the basis of effectively removing excess oil from the skin, it will not over-clean the skin and cause dryness; supplemented with functional components such as protease and antioxidants, the makeup remover can have skin care effects such as removing blackheads and anti-oxidation while having a cleaning effect.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a dual-continuous phase makeup remover that combines makeup removal and care in one, and a preparation method thereof. Background Art

[0002] In recent years, the concept of "using oil to nourish the skin" has become a hot trend. The most commonly used oil products in daily life include essence oil, body oil, hair oil, makeup remover oil, bath oil, etc. On March 2, 2021, the China Business Network (CBNData) and Meilixiuxing jointly released the "2021 Makeup Removal Trend White Paper", which shows that as makeup becomes a daily routine for women, makeup removal has become a high-frequency rigid demand, and the makeup removal market is also undergoing a new round of upgrade tests.

[0003] Traditional makeup remover products are almost entirely made of oils and have strong cleansing power, making them more suitable for oily makeup, but they are too greasy for acne-prone skin. As a newly emerging type of makeup remover product, dual-phase cleansing oil contains a larger amount of water phase in its formula, and has a refreshing and non-greasy texture. It can not only remove makeup, but also is less likely to cause various skin problems than the currently popular makeup remover oils. Its most important feature is that it can be removed with wet hands without affecting the makeup removal power.

[0004] CN114557918A discloses a foaming dual-continuous phase makeup remover cleansing liquid, which includes a composite emulsifier, a composite liquid oil, a polyol, and water; wherein the composite emulsifier is a mixture of an alkyl glycoside and a lipophilic emulsifier, and the lipophilic emulsifier is at least one of polyglycerol fatty acid ester and sorbitol polyether fatty acid ester; and the composite liquid oil is a mixture of polar oil and non-polar oil. The makeup remover solves the problem that lipophilic emulsifiers and synthetic oils cannot foam in a water-based system, improves the difficulty that the previous dual-continuous phase makeup remover products cannot efficiently and instantly remove oily makeup and water-based makeup, and greatly reduces the irritation of traditional cleansing foams.

[0005] CN114732756A provides a dual-continuous phase makeup remover oil, the raw materials for preparation include: emulsifier, emollient, antioxidant, stabilizer, polyol compound, functional additive, water. The makeup remover oil has a good stabilizing effect, reduces the amount of PEG type surfactant used, reduces the irritation to facial skin, and enables the addition amount of oil phase and water phase to be controlled within a wide range, while still maintaining the good effect of the product, and is suitable for large-scale industrial production. At the same time, the makeup remover oil has a strong makeup removal ability, is not greasy, does not require a large amount of clean water to rinse, and is easy to use.

[0006] However, the above disclosed makeup remover products only have the function of makeup removal and cleaning, and cannot take into account the effect of skin care. Putting skin care before makeup removal, that is, "removing makeup and nourishing skin" has become a new market trend. Therefore, it is very necessary to study a makeup remover product that integrates cleaning and care functions. Summary of the invention

[0007] In view of the deficiencies in the prior art, the object of the present invention is to provide a dual-continuous phase makeup remover and a preparation method thereof, wherein the makeup remover not only has excellent cleaning effect, but also has skin care effects such as removing blackheads and whitening, and is mild and non-irritating to the skin, thus satisfying consumers' concept of "nourishing the skin with oil".

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] In a first aspect, the present invention provides a dual-phase makeup remover that combines cleansing and care in one, the components of which include: an emulsifier, liquid oil, a polyol, a protease, an antioxidant and water.

[0010] The so-called dual continuous phase in the present invention refers to a thermodynamically stable system formed by an emulsifier, oil, polyol and other components, wherein the system exists in a layered structure of water, emulsifier and oil, and is not an encapsulation system. The makeup remover of the present invention uses emulsifier, liquid oil, polyol and water as raw materials, so that the prepared dual continuous phase makeup remover has good stability, refreshing skin feel, and has a good removal effect on both water-soluble and oil-soluble makeup. It can effectively remove excess oil from the skin without over-cleansing the skin and causing dryness; supplemented with functional components such as proteases and antioxidants, the makeup remover can have skin care effects such as removing blackheads, whitening and anti-oxidation on the basis of cleaning.

[0011] Preferably, the emulsifier includes any one of polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate or PEG-7 glyceryl cocoate, or a combination of at least two thereof.

[0012] Preferably, the emulsifier is a combination of polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate and PEG-7 glyceryl cocoate.

[0013] In the present invention, polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate and PEG-7 glyceryl cocoate all have good emulsifying properties and are mild and non-irritating to the skin. The emulsifier can ensure that the emulsifying effect and mildness of the makeup remover are more excellent through the synergistic cooperation of the above four.

[0014] Preferably, the mass ratio of polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate and PEG-7 glyceryl cocoate is (7-10):(1-5):(5-10):(2-8).

[0015] Where "7-10" can be 7, 7.5, 8, 8.5, 9, 9.5 or 10, etc.;

[0016] "1-5" can be 1, 1.5, 2, 2.5, 3, 3.5, 4 or 4.5, etc.;

[0017] “5-10” can be 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9 or 9.5, etc.;

[0018] “2-8” can mean 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7 or 7.5, etc.

[0019] Preferably, the liquid oil comprises isopropyl myristate and / or isododecane.

[0020] Preferably, the liquid oil comprises a combination of isopropyl myristate and isododecane.

[0021] In the present invention, the liquid oil is a combination of isopropyl myristate and isododecane. The combination of the two can make the liquid oil have a lower saponification value, contain less or even no lecithin, and can dissolve the oil in blackheads, thereby achieving the effect of effectively reducing blackheads.

[0022] Preferably, the mass ratio of isopropyl myristate to isododecane is (5-25):(1-10).

[0023] Among them, "5-25" can be 5.5, 7, 9.5, 11, 13.5, 15, 17.5, 19, 21.5, 23, etc.;

[0024] "1-10" can independently be 2, 3, 4, 5, 6, 7, 8 or 9, etc.

[0025] Preferably, the polyol includes any one of butylene glycol, propylene glycol or glycerol, or a combination of at least two thereof.

[0026] Preferably, the protease comprises papain.

[0027] In the present invention, the papain is a protease that can decompose protein in acidic, neutral and alkaline environments. It can act on the aged stratum corneum of human skin to promote its decomposition, degradation and removal, thereby achieving the effects of promoting cell growth and whitening and rejuvenating the skin.

[0028] Preferably, the antioxidant comprises niacinamide and / or a plant extract.

[0029] Preferably, the plant extract comprises any one of witch hazel leaf extract, vaccinium angustifolium fruit extract or lactobacillus / citron peel fermentation product extract, or a combination of at least two thereof.

[0030] Preferably, the antioxidant comprises a combination of niacinamide, witch hazel leaf extract, vaccinium angustifolium fruit extract, and lactobacillus / citron peel ferment extract.

[0031] As the preferred technical scheme of the present invention, the niacinamide can reduce transepidermal water loss, improve the barrier function of the skin, and reduce the production of fatty acids and triglycerides in sebum, reduce sebum secretion, and thus have a good effect of shrinking pores and removing blackheads; the North American witch hazel leaf extract, as an antioxidant, can enhance skin cell metabolism, maintain skin elasticity, and has the effect of shrinking pores; the narrow-leaved bilberry fruit extract has a scavenging effect on various free radicals, can prevent skin aging, can prevent ultraviolet rays from invading the skin, and prevent the occurrence of skin photoaging; the lactobacillus / citron peel fermentation product extract has a high content of VC and rich fruit acid in lemon pulp; lemon peel has a strong inhibitory activity of tyrosinase, which can reduce the synthesis of melanin; it can accelerate the metabolism of skin cells, help the aging keratin to fall off, and thus promote the shedding of the generated melanin. The antioxidant of the present invention can make the makeup remover have a better effect of enhancing skin metabolism, whitening and rejuvenating the skin, and has a good effect of shrinking pores and removing blackheads through the combination of the above four.

[0032] Preferably, the mass ratio of niacinamide, witch hazel leaf extract, vaccinium angustifolium fruit extract and lactobacillus / citron peel fermentation product extract is (0.1-3):(0.1-2):(0.1-1):(0.1-1).

[0033] Wherein “0.1-3” can be 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5 or 2.8, etc.;

[0034] “0.1-3” can be 0.2, 0.4, 0.5, 0.8, 1, 1.2, 1.5, 1.8, 2, 2.2, 2.5 or 2.8, etc.;

[0035] The first "0.1-1" can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.;

[0036] The second "0.1-1" can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.

[0037] Preferably, the makeup remover further comprises a preservative and / or a fragrance agent.

[0038] Preferably, the preservative comprises phenoxyethanol.

[0039] Preferably, the flavoring agent comprises essence

[0040] Preferably, the components of the dual-continuous phase makeup remover that combines makeup removal and makeup care in one include, by weight: 1-25 parts of emulsifier, 1-35 parts of liquid oil, 5-40 parts of polyol, 0.1-3 parts of protease, 0.1-5 parts of antioxidant and water.

[0041] The amount of the emulsifier added to the dual-continuous phase makeup remover of the present invention can be 2 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, 22 parts or 24 parts, etc.;

[0042] The amount of the liquid grease added can be 2 parts, 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts or 34 parts, etc.;

[0043] The amount of the polyol added can be 7 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts or 38 parts, etc.;

[0044] The amount of the protease added can be 0.2 parts, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts or 2.8 parts, etc.;

[0045] The antioxidant may be added in an amount of 0.5 parts, 0.8 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0046] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0047] In a second aspect, the present invention provides a method for preparing the dual-phase makeup remover as described in the first aspect, the preparation method comprising: mixing and stirring an emulsifier, liquid oil, polyol, protease, and antioxidant in water to obtain the dual-phase makeup remover.

[0048] The preparation method of the dual-continuous phase makeup remover for makeup removal and makeup care in one of the present invention has a simple process and is easy to operate, and is very suitable for large-scale industrial production.

[0049] Preferably, the preparation method comprises:

[0050] (1) Mixing and stirring the emulsifier and the liquid oil;

[0051] (2) after cooling, mixing and stirring the product of step (1) with a polyol, and then cooling;

[0052] (3) The product of step (2) is mixed with a protease and an antioxidant in water and stirred to obtain the dual-phase makeup remover.

[0053] Preferably, the stirring temperature in step (1) is 70-80°C, for example, it can be 71°C, 72°C, 73°C, 74°C, 75°C, 76°C, 77°C, 78°C or 79°C.

[0054] Preferably, the temperature in step (2) is lowered to 40-50°C, for example, 41°C, 42°C, 43°C, 44°C, 45°C, 46°C, 47°C, 48°C or 49°C.

[0055] Preferably, the cooling to 25-30°C in step (2) may be, for example, 25°C, 26°C, 27°C, 28°C, 29°C or 30°C.

[0056] Preferably, the mixing in step (3) further includes adding a preservative and / or a flavoring agent.

[0057] Preferably, the stirring in step (3) is stopped until the product becomes transparent.

[0058] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0059] Compared with the prior art, the present invention has the following beneficial effects:

[0060] (1) The present invention uses emulsifier, liquid oil, polyol and water as main raw materials, so that the prepared dual-continuous phase makeup remover has good stability, refreshing skin feel, and has a good removal effect on both water-soluble and oil-soluble makeup. On the basis of effectively removing excess oil from the skin, it will not over-clean the skin and cause dryness. In addition, it is supplemented with functional components such as protease and antioxidants, so that the makeup remover can have skin care effects such as removing blackheads, whitening and anti-oxidation while having a cleaning effect.

[0061] (2) The preparation method of the dual-continuous phase makeup remover of the present invention is simple and easy to operate, and is very suitable for large-scale industrial production. DETAILED DESCRIPTION

[0062] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0063] The source information of some raw materials involved in the following examples and comparative examples is as follows:

[0064]

[0065] Other raw materials for preparation can be purchased from commercial sources and can be used.

[0066] Example 1

[0067] The present embodiment provides a dual-continuous phase makeup remover that combines makeup removal and makeup care in one, and its components, measured in parts by weight, include: 9 parts of polyglyceryl-4 oleate, 1.4 parts of polyglyceryl-2 isostearate, 7 parts of polyglyceryl-10 laurate, 5 parts of PEG-7 glyceryl cocoate, 20 parts of isopropyl myristate, 10 parts of isododecane, 15 parts of butylene glycol, 10 parts of propylene glycol, 6 parts of glycerin, 1 part of papain, 1 part of witch hazel leaf extract, 0.5 parts of vaccinium angustifolia fruit extract, 1.2 parts of niacinamide, 1 part of lactobacillus / citron peel fermentation product extract, and water is added to make up to 100 parts.

[0068] The preparation method is as follows:

[0069] (1) polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate, PEG-7 glyceryl cocoate, isopropyl myristate and isododecane were stirred and mixed at 75° C.;

[0070] (2) cooling the mixture to 45° C., mixing the product of step (1) with butanediol, propylene glycol and glycerol, and then cooling the mixture to 30° C.;

[0071] (3) Mix the product of step (2) with papain, witch hazel leaf extract, vaccinium angustifolium fruit extract, niacinamide, and lactobacillus / citron peel fermentation product extract in water and stir until the product becomes transparent.

[0072] Example 2

[0073] The present embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup care, and its components, measured by weight, include: 8 parts of polyglyceryl-4 oleate, 2.4 parts of polyglyceryl-2 isostearate, 7 parts of polyglyceryl-10 laurate, 5 parts of PEG-7 glyceryl cocoate, 20 parts of isopropyl myristate, 10 parts of isododecane, 15 parts of butylene glycol, 10 parts of propylene glycol, 6 parts of glycerin, 1 part of papain, 1 part of witch hazel leaf extract, 0.5 parts of vaccinium angustifolium fruit extract, 1.2 parts of niacinamide, 1 part of lactobacillus / citron peel fermentation product extract, and water is added to make up to 100 parts.

[0074] The preparation method is as follows:

[0075] (1) polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate, PEG-7 glyceryl cocoate, isopropyl myristate and isododecane were stirred and mixed at 80° C.;

[0076] (2) cooling the mixture to 40° C., mixing the product of step (1) with butanediol, propylene glycol and glycerol, and then cooling the mixture to 25° C.;

[0077] (3) Mix the product of step (2) with papain, witch hazel leaf extract, vaccinium angustifolium fruit extract, niacinamide, and lactobacillus / citron peel fermentation product extract in water and stir until the product becomes transparent.

[0078] Example 3

[0079] The present embodiment provides a dual-continuous phase makeup remover that combines makeup removal and makeup care in one, and its components, measured in parts by weight, include: 9 parts of polyglyceryl-4 oleate, 2.4 parts of polyglyceryl-2 isostearate, 7 parts of polyglyceryl-10 laurate, 5 parts of PEG-7 glyceryl cocoate, 20 parts of isopropyl myristate, 10 parts of isododecane, 12 parts of butylene glycol, 12 parts of propylene glycol, 12 parts of glycerin, 2 parts of papain, 0.5 parts of witch hazel leaf extract, 0.5 parts of vaccinium angustifolium fruit extract, 0.5 parts of niacinamide, 0.5 parts of lactobacillus / citron peel fermentation product extract, and water is added to make up to 100 parts.

[0080] The preparation method is as follows:

[0081] (1) polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate, PEG-7 glyceryl cocoate, isopropyl myristate and isododecane were stirred and mixed at 70° C.;

[0082] (2) cooling the mixture to 50° C., mixing the product of step (1) with butanediol, propylene glycol and glycerol, and then cooling the mixture to 30° C.;

[0083] (3) Mix the product of step (2) with papain, witch hazel leaf extract, vaccinium angustifolium fruit extract, niacinamide, and lactobacillus / citron peel fermentation product extract in water and stir until the product becomes transparent.

[0084] Example 4

[0085] This embodiment provides a dual-phase makeup remover that combines makeup removal and makeup protection. The only difference between its components and those of Example 1 is that the emulsifier does not include PEG-7 glyceryl cocoate, and the reduced amount of PEG-7 glyceryl cocoate is added to polyglyceryl-4 oleate, polyglyceryl-2 isostearate, and polyglyceryl-10 laurate in proportion to the number of parts, while other conditions remain unchanged. The preparation method thereof is the same as that of Example 1.

[0086] Example 5

[0087] This embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup care. The components of the makeup remover differ from those of the embodiment 1 only in that the emulsifier does not include polyglyceryl-4 oleate, and the reduced amount of polyglyceryl-4 oleate is added to polyglyceryl-2 isostearate, polyglyceryl-10 laurate, and PEG-7 glyceryl cocoate in proportion to the number of parts, while other conditions remain unchanged. The preparation method thereof is the same as that of the embodiment 1.

[0088] Example 6

[0089] This embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup care. The only difference between its components and those of Example 1 is that the emulsifier does not include polyglyceryl-2 isostearate, and the reduced amount of polyglyceryl-2 isostearate is added to polyglyceryl-4 oleate, polyglyceryl-10 laurate, and PEG-7 glyceryl cocoate in proportion to the number of parts, while other conditions remain unchanged. The preparation method thereof is the same as that of Example 1.

[0090] Example 7

[0091] This embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup protection. The only difference between its components and those of Example 1 is that the emulsifier does not include polyglyceryl-10 laurate, and the reduced amount of polyglyceryl-10 laurate is added to polyglyceryl-4 oleate, polyglyceryl-2 isostearate, and PEG-7 glyceryl cocoate in proportion to the number of parts, and other conditions remain unchanged. The preparation method thereof is the same as that of Example 1.

[0092] Example 8

[0093] This embodiment provides a dual-continuous phase makeup remover that combines makeup removal and makeup protection. The components of the dual-continuous phase makeup remover are different from those of the embodiment 1 only in that the liquid oil does not contain isododecane, and a reduced amount of isododecane is added to isopropyl myristate, and other conditions remain unchanged. The preparation method thereof is similar to that of the embodiment 1.

[0094] Example 9

[0095] This embodiment provides a dual-phase makeup remover that combines makeup removal and makeup protection. The components of the dual-phase makeup remover differ from those of the embodiment 1 only in that the liquid oil does not contain isopropyl myristate, and a reduced amount of isopropyl myristate is added to isododecane, and other conditions remain unchanged. The preparation method thereof is similar to that of the embodiment 1.

[0096] Example 10

[0097] This embodiment provides a dual-continuous phase makeup remover that combines makeup removal and makeup protection. The only difference between its components and those of Example 1 is that niacinamide is not included in the antioxidant, and the reduced amount of niacinamide is added to the North American witch hazel leaf extract, the angustifolia fruit extract, and the lactobacillus / citron peel fermentation product extract in proportion to the number of parts, and other conditions remain unchanged. The preparation method thereof is referred to Example 1.

[0098] Embodiment 11

[0099] This embodiment provides a dual-continuous phase makeup remover that combines makeup removal and makeup protection. The components of the makeup remover differ from those of the embodiment 1 only in that the antioxidant does not include the witch hazel leaf extract, and the reduced amount of the witch hazel leaf extract is added to the niacinamide, the vaccinium angustifolium fruit extract, and the lactobacillus / citron peel fermentation product extract in proportion to the number of parts, and other conditions remain unchanged. The preparation method thereof is referred to the embodiment 1.

[0100] Example 12

[0101] This embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup protection. The components of the makeup remover differ from those of the embodiment 1 only in that the antioxidant does not include the Vaccinium angustifolium fruit extract, and the reduced amount of the Vaccinium angustifolium fruit extract is added to the niacinamide, the Witch Hazel leaf extract, and the Lactobacillus / Citron peel fermentation product extract in proportion to the number of parts, and the other conditions remain unchanged. The preparation method thereof is referred to the embodiment 1.

[0102] Example 13

[0103] This embodiment provides a dual-continuous phase makeup remover for both makeup removal and makeup protection. The components of the makeup remover differ from those of the embodiment 1 only in that the antioxidant does not include the lactobacillus / citron peel fermentation product extract, and the reduced amount of the vaccinium angustifolium fruit extract is added to the niacinamide, the witch hazel leaf extract, and the vaccinium angustifolium fruit extract in proportion to the number of parts, and the other conditions remain unchanged. The preparation method thereof is referred to the embodiment 1.

[0104] Comparative Example 1

[0105] This comparative example provides a makeup remover, the components of which differ from those of Example 1 only in that an antioxidant is not included and a reduced amount of the antioxidant is added to papain, and other conditions remain unchanged. The preparation method thereof is the same as that of Example 1.

[0106] Comparative Example 2

[0107] This comparative example provides a makeup remover, the components of which differ from those of Example 1 only in that protease is not included, and the reduced amount thereof is added to the antioxidant in proportion to the number of parts, and other conditions remain unchanged. The preparation method thereof is the same as that of Example 1.

[0108] Test Example 1

[0109] Cleansing test for makeup (BB cream, lipstick):

[0110] 150 volunteers were divided into 15 groups, with 10 people in each group. The 15 groups of volunteers used the makeup removers prepared in Examples 1-13 and Comparative Examples 1-2 for cleaning, and the specific method was as follows: All volunteers uniformly cleaned the left forearm and the curved side of the right forearm, gently dried the water with a paper towel, and then marked 3 areas of 4cm*4cm as test areas, with at least 2cm between each area, and numbered the 3 test areas as L1, L2, L3 and R1, R2, R3, respectively. After sitting for 20 minutes, the images of each test area were collected using a microscope, and the L*, a*, and b* values ​​of the initial state of the skin were measured by a spectrophotometer.

[0111] Then, a microscope was used to capture images of each test area, and a spectrophotometer was used to measure the L*, a*, and b* values ​​of the skin after applying BB cream / lipstick.

[0112] The L1, L2, L3 and R1, R2, R3 areas are cleaned quantitatively with the makeup remover oil prepared in the embodiment or comparative example through a 1mL syringe. Then rinse with clean water and gently dry the water with a paper towel. Sit still for 30 minutes, use a microscope to collect images of each test area, and use a spectrophotometer to measure the L*, a*, and b* values ​​of the skin after makeup removal and cleaning. L* represents black and white. The larger the L* value, the whiter the skin tends to be, and vice versa. a* represents red-green color. The larger the a* value, the more red the skin tends to be, and vice versa, the more green it tends to be; b* represents blue-yellow color. The larger the b* value, the more yellow the skin tends to be, and vice versa, the blue tends to be. The laboratory maintains a constant temperature and humidity, with a test temperature of 23℃~24℃ and a relative humidity of 50%~60%.

[0113] Cleansing power calculation method: Calculate the skin color difference after applying BB cream / lipstick compared to the initial state, recorded as △E (after application); Calculate the skin color difference after removing makeup and cleaning compared to the initial state, recorded as △E (after cleaning). △E can comprehensively reflect the three-dimensional changes in skin color. The larger the △E value, the more obvious the skin color change, and the smaller the △E value, the closer the skin color is. The cleaning power is calculated by △E. The calculation formula is:

[0114] △E=SQRT(△L* 2 +△a* 2 +△b* 2 )

[0115] Cleaning power = (△E (after application) - △E (after cleaning) / △E (after application)) × 100%

[0116] The results are shown in Table 1 (BB ​​cream) and Table 2 (lipstick):

[0117] Table 1

[0118]

[0119]

[0120] Table 2

[0121] product Cleansing power % (lipstick) Example 1 87.3％ Example 2 86％ Example 3 84％ Example 4 79％ Example 5 79.5％ Example 6 80％ Example 7 81％ Example 8 82％ Example 9 80％ Example 10 86.9％ Embodiment 11 86.8％ Example 12 86.6％ Example 13 86.7％ Comparative Example 1 86.9％ Comparative Example 2 86.1％

[0122] It can be seen from the data in Table 1 and Table 2 that the makeup remover of the present invention has a very good makeup removal ability, and the formula composition of the emulsifier and the liquid oil will have an impact on it.

[0123] Test Example 2

[0124] Grease removal test:

[0125] 90 volunteers were selected, of which 45 were dry skin subjects (randomly divided into 9 groups, 5 people in each group), and 45 were oily skin subjects (randomly divided into 9 groups, 5 people in each group). The fixed parts of the cheeks of the subjects were used as the test areas. The skin oil content of each subject before using the sample and the oil content after using substantially equal amounts of the makeup remover samples of Examples 1-9 for the same time were measured using the CBS skin analysis system in an environment of 25° C. The oil removal rate was calculated according to the following formula, and the arithmetic mean was taken to investigate the cleaning effects of the products on oily skin and dry skin. The measurement results are shown in Table 3.

[0126]

[0127] Table 3

[0128]

[0129] From the data in Table 3, it can be seen that: the data of the subjects with dry skin show that the makeup remover of the present invention will not excessively remove facial grease, will not damage the skin barrier, is basically harmless to the skin, will not cause dry and uncomfortable skin, and the formula composition of the emulsifier and liquid oil will have an impact on it; the data of the subjects with oily skin show that the makeup remover of the present invention has a good oil removal effect, and the formula composition of the emulsifier and liquid oil will have an impact on it.

[0130] Test Example 3

[0131] Blackhead removal effect evaluation:

[0132] A total of 56 volunteers aged between 16 and 65 with obvious blackheads were selected and randomly divided into 7 groups, with 4 females and 4 males in each group (those who had no serious systemic diseases, no immunodeficiency or autoimmune diseases, no history of severe allergies to skin care cosmetics, had not used hormonal drugs or immunosuppressants in the past month, and had not participated in other clinical trials).

[0133] (1) The blackhead removal effect was analyzed using a VISIA skin detector, and the test environment was 22±1°C and the humidity was 50±5%. The subjects were not allowed to use any products (cosmetics or external medicines) 2-3 days before the test. Before the test, the sample application area was marked on the side of the nose of the subject. During the test, the subject first sat quietly in a constant temperature and humidity room for 30 minutes, took photos with VISIA, and evaluated the skin condition of the unused sample. Then, the subject used substantially equal amounts of the makeup removers of Examples 1, 10-13 and Comparative Examples 1-2 in the test area once every morning and evening. After 20 days, the subject first sat quietly in a constant temperature and humidity room for 30 minutes, took photos with VISIA, and evaluated the skin condition after using the sample. The test of the same subject was completed by the same measurement personnel, and the blackhead improvement rate (%) was calculated.

[0134] Blackhead improvement rate (%) = (V2-V1) / V1×100%

[0135] Among them, V2 is the number of blackheads after using the sample for 20 days, and V1 is the number of blackheads before using the sample.

[0136] The results are shown in Table 4:

[0137] Table 4

[0138]

[0139]

[0140] It can be seen from the data in Table 4 that: compared with the comparative example, the makeup remover of the present invention has the effect of helping the skin to remove blackheads, and the components of the antioxidant have a significant synergistic effect in removing blackheads.

[0141] Test Example 4

[0142] The whitening and antioxidant effects of the makeup removers provided in Examples 1, 10-13 and Comparative Examples 1-2 were tested as follows:

[0143] (1) Tyrosinase activity inhibition test

[0144] Mouse melanoma B16 cells in the logarithmic growth phase were inoculated into 6-well cell culture plates and cultured overnight. The test samples were added at a final volume fraction of 1%, and the untreated group was used as the cell control group, with 2 replicates in each group. After 48 hours of culture, the cells were washed once with PBS, 100 μL of lysis buffer was added to each well, the cells were scraped and collected, and the supernatant was obtained by centrifugation. 50 μL of cell supernatant was taken to a 96-well plate, and then 50 μL of 1% L-dopa solution was added, and the cells were incubated at 37°C for 1 hour. The absorbance value was read at 475 nm by M3 plate reader.

[0145] Relative tyrosinase activity (%) = (absorbance value of the assay well - absorbance value of the blank control group) / (absorbance value of the cell control group - absorbance value of the blank control group) × 100%.

[0146] The results of the tyrosinase activity experiment are shown in Table 5, wherein the tyrosinase activity of the control group was 100%.

[0147] (2) Whitening effect human body evaluation

[0148] 70 female volunteers aged between 25 and 50 were selected and randomly divided into 7 groups, with 10 people in each group. The makeup remover oils provided in Examples 1, 10-13 and Comparative Examples 1-2 were used respectively. The inner forearm of either side was used as the test site. No products (cosmetics, external medicines or internal health products) could be used on the test site within one week before the test. The test site was used once in the morning and evening every day for a total of 4 weeks.

[0149] Evaluation method: The Hexameter MX18 was used to evaluate the changes in the melanin content of the subjects' skin before and after using the makeup remover. The measurement range of the instrument used is 0-999. The higher the measured value, the higher the melanin content in the skin.

[0150] The reduction in melanin on the facial skin of the subjects before and after using the makeup remover prepared by the present invention is shown in Table 5.

[0151] Table 5

[0152]

[0153] From the results in Table 5, it can be seen that the makeup remover provided by the present invention has a good whitening and antioxidant effect. It can effectively inhibit the activity of relative tyrosinase. At the same time, for the subjects, it can also significantly reduce the melanin content of the subjects' skin. After the makeup remover is treated, the relative tyrosinase activity is 27.6% and the melanin reduction of the subjects is 25.5%; and the protease and antioxidant have a synergistic effect on the whitening and antioxidant effects.

[0154] Test Example 5

[0155] Safety evaluation:

[0156] The specific method is as follows: 40 females aged 18-35 years old with no history of allergies were selected, and each subject tried the makeup remover prepared in Examples 1-13. After cleaning the back of the subject, the spot tester with the sample was applied to the selected position on the back with a non-irritating tape. After pasting, it was lightly pressed with fingers to make it evenly attached to the skin for 48 hours. The subject kept the patch area dry within 48 hours, and avoided intense exercise, scratching the patch area, long-term sunlight exposure, etc. After 48 hours, the tester was removed and marked, and after 30 minutes, the indentation disappeared and the judgment was made under sufficient light.

[0157] The grading standards for adverse skin reactions are shown in Table 6:

[0158] Table 6

[0159]

[0160] The results are shown in Table 7:

[0161] Table 7

[0162]

[0163]

[0164] It can be seen from the data in Table 7 that all the subjects had negative reactions, which indicates that the makeup remover of the present invention has no adverse reactions to the human body and is highly safe.

[0165] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a dual-continuous phase makeup remover and a preparation method thereof, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0166] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0167] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A dual-continuous phase makeup remover that combines makeup removal and makeup care in one, characterized in that: The components of the dual-continuous phase makeup remover for makeup removal and makeup protection include: emulsifier, liquid oil, polyol, protease, antioxidant and water; The emulsifier is a combination of polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate and PEG-7 glyceryl cocoate; the mass ratio of polyglyceryl-4 oleate, polyglyceryl-2 isostearate, polyglyceryl-10 laurate and PEG-7 glyceryl cocoate is (7-10): (1-5): (5-10): (2-8); The liquid oil comprises a combination of isopropyl myristate and isododecane; the mass ratio of isopropyl myristate to isododecane is (5-25):(1-10); The antioxidant comprises a combination of niacinamide, witch hazel leaf extract, bilberry fruit extract and lactobacillus / citron peel fermentation product extract; the mass ratio of niacinamide, witch hazel leaf extract, bilberry fruit extract and lactobacillus / citron peel fermentation product extract is (0.1-3): (0.1-2): (0.1-1): (0.1-1).

2. The dual-continuous phase makeup remover according to claim 1, characterized in that: The polyol includes any one of butylene glycol, propylene glycol or glycerol, or a combination of at least two of them.

3. The dual-continuous phase makeup remover according to claim 1, characterized in that: The proteases include papain.

4. The dual-continuous phase makeup remover according to claim 1, characterized in that: The makeup remover also includes preservatives and / or fragrance agents.

5. The dual-continuous phase makeup remover according to claim 4, characterized in that: The preservatives include phenoxyethanol.

6. The dual-continuous phase makeup remover according to claim 4, characterized in that: The flavoring agent includes essence.

7. The dual-continuous phase makeup remover according to claim 1, characterized in that: The components of the dual-continuous phase makeup remover, which combines makeup removal and makeup care in one, include, by weight: 1-25 parts of emulsifier, 1-35 parts of liquid oil, 5-40 parts of polyol, 0.1-3 parts of protease, 0.1-5 parts of antioxidant and water.

8. The method for preparing a dual-continuous phase makeup remover according to any one of claims 1 to 7, characterized in that: The preparation method comprises: mixing and stirring an emulsifier, liquid oil, polyol, protease, antioxidant and optionally a preservative and / or a fragrance agent in water to obtain the dual-continuous phase makeup remover for both makeup removal and makeup care.

9. The method for preparing the dual-continuous phase makeup remover according to claim 8, characterized in that: The preparation method comprises: (1) Mix and stir the emulsifier and liquid oil; (2) After cooling, the product of step (1) is mixed with the polyol and stirred, and then cooled; (3) The product of step (2) is mixed with a protease and an antioxidant in water and stirred to obtain the dual-phase makeup remover.

10. The method for preparing the dual-continuous phase makeup remover according to claim 9, characterized in that: The stirring temperature in step (1) is 70-80°C.

11. The method for preparing the dual-continuous phase makeup remover according to claim 9, characterized in that: Step (2) is cooling to 40-50°C.

12. The method for preparing the dual-continuous phase makeup remover according to claim 9, characterized in that: Step (2) is cooling to 25-30°C.

13. The method for preparing the dual-continuous phase makeup remover according to claim 9, characterized in that: The mixing in step (3) also includes adding a preservative and / or a flavoring agent.

14. The method for preparing the dual-continuous phase makeup remover according to claim 9, characterized in that: The stirring in step (3) is continued until the product becomes transparent.

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