A Chinese medicine patch for treating subcutaneous hematoma of limbs

Abstract

The present invention relates to a Chinese medicine patch for treating subcutaneous hematoma of limbs, which is prepared from the following raw materials: 6-14 parts of saltpeter, 6-14 parts of angelica root, 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of earthworm, 5-13 parts of fenugreek, 1-5 parts of blood clotting; usage: saltpeter is knocked into fine particles, the remaining medicines are ground into fine powder, 50g of maltose, 15g of flour, warm water are used to reconcile, stirring is like a thick paste, 3-5mm thick is applied to the swollen and painful affected area, gauze is wrapped outside, and it is changed once a day. The present invention also provides the use of the Chinese medicine composition. Its advantage is that the Chinese medicine composition of the present invention meets the compatibility of monarch, minister, assistant and envoy, and plays the effect of promoting blood circulation and removing blood stasis, softening and dispersing nodules.

Description

Technical Field

[0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine patch for treating subcutaneous hematoma of limbs. Background Art

[0002] Subcutaneous hematoma generally refers to a hematoma formed when the subcutaneous blood vessel wall is damaged and blood seeps out of the blood vessel. Most of the subcutaneous hematomas are caused by external impact, which causes certain damage to the blood vessel wall, causing blood to seep out of the blood vessel, and are accompanied by symptoms such as skin swelling or pain. If it occurs within 24 hours, you can use ice cubes to apply cold compress to the local area, which can reduce swelling and stop bleeding. If it exceeds 24 hours, you can use a hot towel to apply hot compress to the local area, which can promote blood circulation and effectively absorb subcutaneous blood stasis, thereby alleviating symptoms.

[0003] Chinese patent document CN201110351575.4 discloses "a Chinese herbal external ointment for treating traumatic fractures", which comprises raw arisaema, raw gardenia, raw pinellia, raw aconite, raw chuanwu, fragrant angelica, true sappan wood, earthworm, magnolia officinalis, drynaria, cyperus rotundus, galangal, zelan leaf, nard, catechu, safflower, bauhinia bark, live earthworm, natural copper, notoginseng, processed frankincense, processed myrrh, cinnabar, clove, sea dragon, seahorse, chuanxiong, acanthopanax bark, whole angelica, sesame oil, and camphor bark. The above 31 Chinese herbal medicines are combined and made into an ointment by traditional Chinese medicine preparation method, and the ointment is spread into the ointment and applied to the affected area. The invention is simple to operate for treating bone injury symptoms, has fast pain relief for various fractures, less pain for patients, short treatment cycle, and no recurrence after recovery.

[0004] There is no report about the Chinese medicine patch for treating subcutaneous hematoma of limbs of the present invention. Summary of the invention

[0005] The first object of the present invention is to provide a Chinese medicine composition for treating subcutaneous hematoma of limbs in view of the deficiencies in the prior art.

[0006] The second object of the present invention is to provide the use of the Chinese medicine composition in preparing a medicine for treating subcutaneous hematoma of limbs.

[0007] To achieve the above first purpose, the technical solution adopted by the present invention is: a traditional Chinese medicine composition for treating subcutaneous hematoma of limbs, which is prepared from the following raw materials: 6-14 parts of saltpeter, 6-14 parts of angelica root, 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of Eupolyphaga sinensis, 5-13 parts of fenugreek, and 1-5 parts of dragon's blood.

[0008] Preferably, the Chinese medicine composition is prepared from the following raw materials: 8-12 parts of saltpeter, 8-12 parts of angelica root, 5-7 parts of frankincense, 5-7 parts of myrrh, 5-7 parts of Eupolyphaga sinensis, 7-11 parts of fenugreek, and 2-4 parts of Sanguisorba officinalis.

[0009] More preferably, the Chinese medicine composition is prepared from the following raw materials: 10 parts of saltpeter, 10 parts of angelica root, 6 parts of frankincense, 6 parts of myrrh, 6 parts of Eupolyphaga sinensis, 9 parts of Vaccaria segetalis, and 3 parts of Sanguisorba officinalis.

[0010] Preferably, the method of using the Chinese medicine composition is: beat saltpeter into fine particles, grind the other medicines into fine powder, mix with 50g maltose, 15g flour, and warm water, stir into a thick paste, apply 3-5mm thick on the swollen and painful area, wrap with gauze, and change it once a day.

[0011] In a second aspect, the present invention provides use of the above-mentioned traditional Chinese medicine composition in the preparation of a drug for treating traumatic blood stasis lesions.

[0012] Preferably, the traumatic blood stasis lesion is subcutaneous hematoma of the limbs.

[0013] Preferably, the symptoms of subcutaneous hematoma of the limbs are bruises on the limbs, blood stasis, and hard lumps.

[0014] To achieve the third purpose, the technical solution adopted by the present invention is:

[0015] A traditional Chinese medicine patch for treating subcutaneous hematoma of limbs, wherein the patch is made of the traditional Chinese medicine composition according to any one of claims 1 to 3.

[0016] The present invention has the advantages that:

[0017] In the formula, Xuejie can invigorate blood circulation, remove blood stasis, stop bleeding and relieve pain, and is the main medicine; frankincense and myrrh can invigorate blood circulation, remove blood stasis and relieve pain, and the two are together as assistant medicines; saltpeter tastes salty and bitter, and is cold in nature, and has the effects of purging qi and attacking accumulation, moistening dryness and softening hard masses, and clearing away heat and relieving swelling; Angelica sinensis, Scolopendra subspinipes, and Vaccaria segetalis can invigorate blood circulation, remove blood stasis and relieve pain, clear away heat and detoxify and reduce swelling, and are together as adjuvant medicines; all the medicines are used together to achieve the effects of invigorating blood circulation, removing blood stasis, softening hard masses and dispersing nodules. DETAILED DESCRIPTION

[0018] The specific implementation methods provided by the present invention are described in detail below in conjunction with examples.

[0019] Example 1 Chinese medicine composition (I)

[0020] 10 parts of saltpeter, 10 parts of angelica root, 6 parts of frankincense, 6 parts of myrrh, 6 parts of Eupolyphaga sinensis, 9 parts of fenugreek, and 3 parts of Sanguisorba officinalis.

[0021] Example 2 Chinese medicine composition (II)

[0022] 10 parts of saltpeter, 8 parts of angelica root, 7 parts of frankincense, 4 parts of myrrh, 8 parts of Eupolyphaga sinensis, 9 parts of fenugreek, and 2 parts of Sanguisorba officinalis.

[0023] Example 3 Chinese medicine composition (III)

[0024] 8 parts of saltpeter, 12 parts of angelica root, 4 parts of frankincense, 8 parts of myrrh, 6 parts of Eupolyphaga sinensis, 7 parts of Vaccaria segetalis, and 4 parts of Sanguisorba officinalis.

[0025] Example 4 Chinese medicine composition (four)

[0026] 12 parts of saltpeter, 6 parts of angelica root, 8 parts of frankincense, 6 parts of myrrh, 5 parts of Eupolyphaga sinensis, 11 parts of fenugreek, and 1 part of Sanguisorba officinalis.

[0027] Example 5 Chinese medicine composition (V)

[0028] 6 parts of saltpeter, 14 parts of angelica root, 6 parts of frankincense, 5 parts of myrrh, 7 parts of Eupolyphaga sinensis, 5 parts of fenugreek, and 5 parts of Sanguisorba officinalis.

[0029] Example 6 Chinese medicine composition (six)

[0030] 14 parts of saltpeter, 10 parts of angelica root, 5 parts of frankincense, 7 parts of myrrh, 4 parts of Eupolyphaga sinensis, 13 parts of fenugreek, and 3 parts of Sanguisorba officinalis.

[0031] Example 7 Chinese medicine composition (VII)

[0032] 10 parts of saltpeter, 12 parts of angelica root, 4 parts of frankincense, 8 parts of myrrh, 6 parts of Eupolyphaga sinensis, 7 parts of Vaccaria segetalis, and 4 parts of Sanguisorba officinalis.

[0033] Example 8 Chinese medicine composition (VIII)

[0034] 10 parts of saltpeter, 6 parts of angelica root, 8 parts of frankincense, 6 parts of myrrh, 5 parts of Eupolyphaga sinensis, 11 parts of fenugreek, and 1 part of Sanguisorba officinalis.

[0035] Example 9 Chinese medicine composition (IX)

[0036] 10 parts of saltpeter, 14 parts of angelica root, 6 parts of frankincense, 5 parts of myrrh, 7 parts of Eupolyphaga sinensis, 5 parts of fenugreek, and 5 parts of Sanguisorba officinalis.

[0037] Example 10 Chinese medicine composition (ten)

[0038] 6 parts of saltpeter, 10 parts of angelica root, 5 parts of frankincense, 7 parts of myrrh, 4 parts of Eupolyphaga sinensis, 13 parts of Vaccaria segetalis, and 3 parts of Sanguisorba officinalis.

[0039] Example 11 Chinese medicine composition (XI)

[0040] 14 parts of saltpeter, 8 parts of angelica root, 7 parts of frankincense, 4 parts of myrrh, 8 parts of Eupolyphaga sinensis, 9 parts of fenugreek, and 2 parts of Sanguisorba officinalis.

[0041] Example 12 Animal Experiment

[0042] 1. Experimental Materials

[0043] 1.1 Animals

[0044] Fifty SD male rats, weighing 260-280 g, were purchased from Shanghai Slake Experimental Animal Co., Ltd. All rats were given free access to food and water and were adaptively fed for 1 week.

[0045] 1.2 Drugs and reagents

[0046] The Chinese medicine composition of the present invention is prepared by: 10 parts of saltpeter, 10 parts of angelica root, 6 parts of frankincense, 6 parts of myrrh, 6 parts of Eupolyphaga sinensis, 9 parts of fenugreek, and 3 parts of Sanguisorba officinalis.

[0047] Preparation of the second Chinese medicine composition of the present invention: 14 parts of saltpeter, 8 parts of angelica root, 7 parts of frankincense, 4 parts of myrrh, 8 parts of Eupolyphaga sinensis, 9 parts of Vaccaria segetalis, and 2 parts of Sanguisorba officinalis;

[0048] The control group 1 was prepared as follows: 14 parts of rhubarb, 8 parts of angelica root, 7 parts of drynaria, 4 parts of myrrh, 8 parts of Eupolyphaga sinensis, 9 parts of safflower, and 2 parts of Sanguisorba officinalis;

[0049] Preparation of control group 2: 10 parts of saltpeter, 10 parts of Trigonum multiflorum, 6 parts of frankincense, 6 parts of Chuanxiong, 6 parts of Dabogu, 9 parts of Vaccaria segetalis, 3 parts of Sanguisorba officinalis;

[0050] Model group preparation: normal saline;

[0051] Main instruments: vernier caliper, weights.

[0052] 2. Methods

[0053] 2.1 Modeling and grouping

[0054] Rats were randomly divided into treatment group 1, treatment group 2, control group 1, control group 2, and model group, with 10 rats in each group for modeling. Before the experiment, the right hind legs of the rats were depilated, and the middle of the legs were marked with a marker pen. The diameter of the middle of the hind legs was measured with a vernier caliper, and a 200g weight was dropped from 50cm to hit the thigh 3-4 times to create a traumatic blood stasis model. The diameter of the same part was measured again after 5h, and the difference between the two measurements represented the amount of thigh swelling.

[0055] 2.2 Experimental plan

[0056] After modeling, the rats in the treatment group and the control group were given powdered drugs and mixed with appropriate amount of physiological saline to make paste and applied with gauze. The model group was given normal temperature physiological saline gauze wet compress, each wet compress was 1.5 hours, once a day, and the medication was given continuously for 21 days. At the end of the medication, 3-5 ml of anticoagulated blood was taken from the carotid artery, and centrifuged (3000r / min, 20min) after standing for 2 hours, and the whole blood and plasma viscosity were measured.

[0057] 2.3 Statistical methods

[0058] SPSS 25.0 software was used for statistical processing of data. Measurement data were expressed as (x±s), and those that met normal distribution were analyzed by t test.

[0059] 2.4 Indicators

[0060] (1) Effects on rats with traumatic blood stasis;

[0061] (2) Effects on hemorheology in rats.

[0062] 2.5 Results

[0063] 2.5.1 Effects on rats with traumatic blood stasis

[0064] Experimental observations showed that there was no significant difference in the diameter of the hind legs of the rats in each group before modeling (p>0.05), which was comparable; after the right hind limbs of the rats were hit by heavy objects, the limbs were obviously swollen, the limb diameter increased significantly compared with normal, and they refused to be pressed; some rats had hemiplegia and were unable to move freely. After 3 weeks of drug administration, the control group improved compared with the model group (p<0.05), but overall there was no significant improvement compared with the treatment group rats; the limb swelling of the rats in treatment group 1 and treatment group 2 subsided faster than that of the rats in the model group, the subcutaneous bruises were improved, the movements were free, and the diameter of the right hind legs was significantly reduced (p<0.01), as shown in Table 1.

[0065] Table 1 Effects of traumatic blood stasis on rats

[0066]

[0067] Note: 1) Compared with the model group, (p<0.05, p<0.01); 2) Compared with the control group, p<0.05.

[0068] 2.5.2 Effects on rat blood rheology

[0069] The blood rheology indexes showed that compared with the model group, the whole blood viscosity (low shear) and plasma viscosity of the rats in the control group 1 and 2 were not significantly reduced, with no statistical difference (p>0.05); the whole blood viscosity (high shear) of the rats in the control group 1 and 2 was significantly reduced, with statistical difference (p<0.05); the whole blood viscosity (low shear, high shear) of the rats in the treatment group 1 and 2 was significantly reduced (p<0.01), with statistical significance. The drugs in both the treatment group 1 and the treatment group 2 can reduce the plasma viscosity of the rats (p<0.01).

[0070] Table 2 Effects on rat blood rheology

[0071]

[0072] Note: 1) Compared with the model group, (p<0.01, p<0.05); 2) Compared with the control group, (p<0.01).

[0073] The above is only a preferred embodiment of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and supplements without departing from the method of the present invention. These improvements and supplements should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating subcutaneous hematoma of limbs, characterized in that: The invention is prepared from the following raw materials: 6-14 parts of saltpeter, 6-14 parts of angelica root, 4-8 parts of frankincense, 4-8 parts of myrrh, 4-8 parts of Eupolyphaga sinensis, 5-13 parts of fenugreek and 1-5 parts of dragon's blood.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention is prepared from the following raw materials: 8-12 parts of saltpeter, 8-12 parts of angelica root, 5-7 parts of frankincense, 5-7 parts of myrrh, 5-7 parts of Eupolyphaga sinensis, 7-11 parts of fenugreek and 2-4 parts of dragon's blood.

3. The Chinese medicine composition according to claim 2, characterized in that: The invention is prepared from the following raw materials: 10 parts of saltpeter, 10 parts of angelica root, 6 parts of frankincense, 6 parts of myrrh, 6 parts of Eupolyphaga sinensis, 9 parts of fenugreek and 3 parts of dragon's blood.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating traumatic blood stasis.

5. The use according to claim 4, characterized in that: The traumatic blood stasis lesions are subcutaneous hematomas of the limbs.

6. A Chinese medicine patch for treating subcutaneous hematoma of limbs, characterized in that: The patch is made of the Chinese medicine composition according to any one of claims 1-3.

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