A developer and its application, a developer suture and its preparation method

Abstract

The present application relates to the technical field of medical materials, and specifically discloses a developer and its application, a developed suture, and a method for preparing the same. The present application discloses a developer comprising the following components in parts by weight: 8-12 parts of ultra-high molecular weight polyethylene; 0.25-0.35 parts of a developer; 0.02-0.06 parts of a fatty acid; and 95-105 parts of a lubricant. The present application also discloses the application of the developer in medical developing materials. Furthermore, the present application discloses a developed suture prepared using the developer and a method for preparing the developed suture. The developed suture prepared using the developer provided in the present application has excellent mechanical properties and developing effects.

Description

Technical Field

[0001] The present application relates to the technical field of medical materials, and in particular to a developer and its application, a developer suture and its preparation method. Background Art

[0002] In sports medicine, the treatment and rehabilitation of injuries to joints, soft tissues, ligaments, and other areas often require the use of medical suture anchors to reconnect soft tissue to bone. Most medical suture anchors used clinically are made of metal materials. These suture anchors offer good grip, ease of implantation, and ease of X-ray evaluation. However, these suture anchors do not display images under X-rays, hindering regular observation of tissue bonding. Therefore, there is a need for a suture material with imaging properties.

[0003] Currently, imaging technology is primarily used with imaging gauze, which has a developing line embedded in it. Under X-ray irradiation, the developing line is impermeable to the X-ray and clearly displays an image on the X-ray monitor or film. Using this developing gauze, it is possible to quickly and easily determine if any gauze remains inside a patient's body, allowing for prompt removal, sparing the patient pain and preventing medical accidents.

[0004] However, the mechanical properties of the developing thread used in developing gauze are poor and do not meet the performance requirements of medical sutures. Therefore, it is urgent to provide a developing suture that meets the mechanical properties of medical sutures. Summary of the Invention

[0005] In order to obtain a developing suture with excellent mechanical properties, the present application provides a developing solution and its application, a developing suture and its preparation method.

[0006] In a first aspect, the present application provides a developer.

[0007] A developer adopts the following technical solution:

[0008] A developer comprises the following components in parts by weight: 8-12 parts of ultra-high molecular weight polyethylene; 0.25-0.35 parts of a developer; 0.02-0.06 parts of a fatty acid; and 95-105 parts of a lubricant.

[0009] The present application utilizes ultra-high molecular weight polyethylene as the main body, and adds developer, fatty acid and lubricant as the main components of the developer, which can obtain high-strength, high-modulus and good elongation at break developing sutures, indicating that the mechanical properties of the developing sutures prepared by the present application are relatively excellent; and the developing sutures can present clear and bright images under X-ray irradiation, indicating that the developing effect of the developing sutures prepared by the present application is good.

[0010] Preferably, the weight average molecular weight of the ultra-high molecular weight polyethylene is (3-12)×10 6 g / mol.

[0011] In a specific embodiment, the weight average molecular weight of the ultra-high molecular weight polyethylene can be 3×10 6 g / mol, 8×10 6 g / mol, 12×10 6 g / mol.

[0012] In some specific embodiments, the weight average molecular weight of the ultra-high molecular weight polyethylene can also be (3-8)×10 6 g / mol, (8-12)×10 6 g / mol.

[0013] The ultra-high molecular weight polyethylene used in this application has excellent flexibility and durability, making it suitable for preparing medical developing sutures and providing them with excellent mechanical properties. Furthermore, the inventors of this application have discovered that controlling the weight-average molecular weight of the ultra-high molecular weight polyethylene within the aforementioned range can improve the developing effect of the developing sutures and ensure that the mechanical properties of the developing sutures remain at a high level.

[0014] Preferably, the developer is selected from at least one of bismuth trioxide, barium sulfate, tungsten powder, and calcium tungstate.

[0015] Furthermore, the developer is bismuth trioxide.

[0016] Bismuth trioxide (BTO) developer appears yellow, barium sulfate (BSO) developer appears white, tungsten powder (Tungsten) developer appears black, and calcium tungstate (CTO) developer appears dark gray. All of these developers can be used to prepare developer solutions. However, considering the biocompatibility of the materials, this application uses bismuth trioxide (BTO) as the developer, which has lower toxicity.

[0017] Furthermore, the particle size of the developer is 0.1-0.8 μm.

[0018] After numerous experiments, the inventors of this application discovered that when the developer powder particle size is large, the developed film appears rough, resulting in poor seam development. When the developer powder particle size is small, the surface energy of the powder is high, and the powder particles tend to aggregate, making it extremely difficult to disperse the developer, resulting in an uneven distribution of the developed film and poor seam development. Therefore, this application controls the developer particle size within the above range.

[0019] Preferably, the lubricant is selected from at least one of white oil, liquid paraffin, decahydronaphthalene, tetrahydronaphthalene, xylene and toluene.

[0020] The ultra-high molecular weight polyethylene used in this application has a large molecular weight, high viscosity, severe intra- and inter-molecular entanglement, and poor dissolution uniformity. The use of the above-mentioned lubricant can significantly improve the dissolution uniformity of ultra-high molecular weight polyethylene. Furthermore, to reduce raw material costs and material toxicity, this application selected white oil as the lubricant.

[0021] Preferably, the fatty acid is at least one of lauric acid, palmitic acid and myristic acid.

[0022] Furthermore, the fatty acids are lauric acid and palmitic acid; the weight ratio of the lauric acid to the palmitic acid is 3:(1-2).

[0023] In a specific embodiment, the weight ratio of the lauric acid to the palmitic acid may be 3:1, 3:1.5, or 3:2.

[0024] In some specific embodiments, the weight ratio of the lauric acid to the palmitic acid can also be 3:(1-1.5) or 3:(1.5-2).

[0025] Experimental analysis shows that, compared to using any one of lauric acid, palmitic acid, and myristic acid alone as the fatty acid, or using lauric acid and myristic acid together as the fatty acid, or using myristic acid and palmitic acid together as the fatty acid, the present application's use of lauric acid and palmitic acid as the fatty acid can further improve the mechanical properties and developing effect of the developing suture. Furthermore, the present application has discovered that controlling the weight ratio of lauric acid to palmitic acid within the above-mentioned range can further improve the mechanical properties and developing effect of the developing suture.

[0026] In a second aspect, the present application provides the use of the above-mentioned developer in medical developer materials.

[0027] In a third aspect, the present application provides a developing suture prepared using the above-mentioned developer.

[0028] The formulation provided herein can produce a medical-grade suture that meets the mechanical property requirements of ASTM F2848-10 and exhibits good biocompatibility. Furthermore, the suture can produce clear and bright images under X-ray irradiation, facilitating diagnosis and treatment during surgery.

[0029] In a fourth aspect, the present application provides a method for preparing the above-mentioned developing suture, which specifically comprises the following steps:

[0030] Dispersing the ultra-high molecular weight polyethylene in a lubricant, then adding the bismuth trioxide and the fatty acid, and uniformly mixing the components with the aid of ultrasound to obtain a mixed slurry;

[0031] Extruding and spinning the mixed slurry and cooling it to obtain jelly fibers;

[0032] Allowing the jelly fibers to stand at room temperature to phase separate the lubricant;

[0033] The separated fibers are placed in an extractant, subjected to ultrasonic extraction, and then dried to obtain the developed suture.

[0034] The present application utilizes the preparation method provided above to mix, extrude, spin, cool, phase separate the developer, and then extract and dry it to obtain a developed suture with excellent mechanical properties and developing effects.

[0035] Preferably, the ultrasonic-assisted parameters are: temperature 38-42° C.; frequency 35-50 kHz; and time 1.5-2.5 h.

[0036] By adopting the above-mentioned ultrasonic-assisted technical solution, the present application can fully swell the ultra-high molecular weight polyethylene in the lubricant, and can effectively improve the dispersibility of the developer and fatty acid in the product, thereby further improving the quality of the developed suture.

[0037] Preferably, the extractant is selected from at least one of petroleum ether, ethyl acetate and dichloromethane.

[0038] By adopting the above technical solution, the present application places the separated fibers in an extractant, which can remove a small amount of residual lubricant and other impurities, thereby improving the quality of the product.

[0039] Preferably, the extrusion temperature is 230-250°C.

[0040] Preferably, the cooling is slow cooling, and the specific steps are:

[0041] The spun fiber is cooled in three stages: hot water, warm water, and cold water;

[0042] The temperature of the hot water is 80-90°C; the temperature of the warm water is 50-60°C; and the temperature of the cold water is 20-30°C.

[0043] Through experimental analysis, it can be seen that compared with the use of cold water rapid cooling process, or the hot water-cold water two-stage slow cooling process, or the warm water-cold water two-stage slow cooling process to prepare the developing suture, the present application uses the above-mentioned hot water-warm water-cold water three-stage cooling process to obtain frozen gel fiber to prepare the developing suture, which can effectively reduce the stress caused by the cooling temperature on the developing suture, which is beneficial to improving the smoothness and appearance quality of the developing suture; at the same time, the above-mentioned slow cooling process can improve the distribution uniformity of the various components of the developing suture, thereby further improving the mechanical properties and development effect of the developing suture.

[0044] In summary, the technical solution of this application has the following effects:

[0045] This application utilizes ultra-high molecular weight polyethylene, a developer, a fatty acid, and a lubricant as the primary components of the developer solution. By carefully selecting the amounts of each component added, the developer can produce a developer suture with high strength, high modulus, and good elongation at break. Furthermore, the developer suture produces a clear and bright image under X-ray irradiation. This demonstrates that the developer suture prepared in this application exhibits excellent mechanical properties and a good developer effect.

[0046] The present application can further improve the mechanical properties and developing effect of the developing suture by screening the weight average molecular weight of ultra-high molecular weight polyethylene, the developer and the type of fatty acid.

[0047] In the present application, the components in the developer are mixed with the aid of ultrasound, the fibers after extrusion and spinning are cooled, and then phase separation and extraction drying are performed to obtain a developed suture with excellent mechanical properties and developing effects.

[0048] By adopting a hot water-warm water-cold water three-stage cooling process to prepare the developing suture, the present application can further improve the mechanical properties and developing effect of the developing suture. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 This is a picture of the developed suture under X-ray irradiation in Example 2 of the present application. DETAILED DESCRIPTION

[0050] In a first aspect, the present application provides a developer comprising the following components in parts by weight: 8-12 parts of ultra-high molecular weight polyethylene; 0.25-0.35 parts of a developer; 0.02-0.06 parts of a fatty acid; and 95-105 parts of a lubricant.

[0051] Among them, the weight average molecular weight of ultra-high molecular weight polyethylene is (3-12)×10 6 g / mol.

[0052] The developer is selected from at least one of bismuth trioxide, barium sulfate, tungsten powder, and calcium tungstate.

[0053] Furthermore, the developer is bismuth trioxide with a particle size of 0.1-0.8 μm.

[0054] Meanwhile, the lubricant is selected from at least one of white oil, liquid paraffin, decahydronaphthalene, tetrahydronaphthalene, xylene and toluene.

[0055] In addition, the fatty acid is at least one of lauric acid, palmitic acid, and myristic acid.

[0056] Furthermore, the fatty acid is lauric acid and palmitic acid in a weight ratio of 3:(1-2).

[0057] In a second aspect, the present application provides the use of the above-mentioned developer in medical developer materials.

[0058] In a third aspect, the present application provides a developing suture prepared using the above-mentioned developer.

[0059] In a fourth aspect, the present application provides a method for preparing the above-mentioned developing suture, which specifically comprises the following steps:

[0060] Ultra-high molecular weight polyethylene is dispersed in a lubricant, and then bismuth trioxide and fatty acid are added, and the components are mixed uniformly with the aid of ultrasound to obtain a mixed slurry;

[0061] The mixed slurry is subjected to extrusion spinning and cooling to obtain gel fibers;

[0062] The jelly fibers were allowed to stand at room temperature to phase separate and remove the lubricant;

[0063] The separated fibers are placed in an extractant, subjected to ultrasonic extraction, and then dried to obtain a developed suture.

[0064] The ultrasonic-assisted parameters are as follows: temperature 38-42°C; frequency 35-50kHz; and time 1.5-2.5h.

[0065] Specifically, the extractant is selected from at least one of petroleum ether, ethyl acetate, and dichloromethane.

[0066] At the same time, the extrusion temperature is 230-250°C.

[0067] In addition, cooling is slow cooling, the specific steps are:

[0068] The spun fiber is cooled in three stages: hot water, warm water, and cold water; the hot water temperature is 80-90°C; the warm water temperature is 50-60°C; and the cold water temperature is 20-30°C.

[0069] The present application is further described in detail below in conjunction with examples, comparative examples and performance testing experiments. These examples should not be construed as limiting the scope of protection claimed in this application.

[0070] Example

[0071] Examples 1-7

[0072] Examples 1-7 each provide a developing suture.

[0073] The difference between the above embodiments is that the addition amount of each component in the developing suture is specifically shown in Table 1.

[0074] The method for preparing the developing suture in the above embodiment specifically comprises the following steps:

[0075] According to Table 1, the corresponding weight of ultra-high molecular weight polyethylene (UHMWPE) was weighed and dispersed in 100 g of white oil. Bismuth trioxide and fatty acid were then added. Ultrasonication was performed for 2 h at an ultrasonic temperature of 40°C and a frequency of 40 kHz to obtain a mixed slurry. The bismuth trioxide had a particle size of 0.5 μm, and the fatty acid was lauric acid and palmitic acid in a weight ratio of 3:1.5.

[0076] The mixed slurry is fed into a twin-screw extruder at a temperature of 230-250°C. After the extrudate becomes transparent, a spinneret assembly is installed for spinning.

[0077] The spun fibers were sequentially treated with 85°C hot water for 20 minutes, 55°C warm water for 20 minutes, and 25°C cold water for 20 minutes, followed by a three-stage slow cooling process to obtain gel fibers.

[0078] The gel fibers were allowed to stand at room temperature for 24 hours to allow the gel fibers to undergo phase separation and separate out the white oil;

[0079] The separated fibers were placed in an analytically pure dichloroethane extractant and subjected to ultrasonic extraction. After the extraction, the fibers were dried at 90° C. to obtain a developed suture.

[0080] Table 1 Addition amount of each component in the developing suture in Examples 1-7

[0081]

[0082]

[0083] Examples 8-11

[0084] Examples 8-11 each provide a developing suture.

[0085] The difference between the above embodiment and embodiment 2 is that the weight average molecular weight of the ultra-high molecular weight polyethylene is specifically shown in Table 2.

[0086] Table 2 Weight average molecular weight of ultra-high molecular weight polyethylene in Examples 2, 8-11

[0087]

[0088] Examples 12-18

[0089] Examples 12-18 each provide a developing suture.

[0090] The difference between the above embodiment and embodiment 2 is that the composition of fatty acids is specifically shown in Table 2.

[0091] Table 3 Composition of fatty acids in Examples 2, 12-18

[0092]

[0093]

[0094] Example 19

[0095] This embodiment provides a developing seam.

[0096] The difference between this embodiment and embodiment 2 is that the cooling method in the preparation method of the developing suture is different, and the specific steps are:

[0097] The fibers obtained by spinning were quenched by passing through cold water at 25°C to obtain gel fibers.

[0098] Example 20

[0099] This embodiment provides a developing seam.

[0100] The difference between this embodiment and embodiment 2 is that the cooling method in the preparation method of the developing suture is different, and the specific steps are:

[0101] The fibers obtained by spinning were sequentially treated with hot water at 85° C. for 20 min and cold water at 25° C. for 20 min, and then subjected to a two-stage slow cooling process to obtain gel fibers.

[0102] Example 21

[0103] This embodiment provides a developing seam.

[0104] The difference between this embodiment and embodiment 2 is that the cooling method in the preparation method of the developing suture is different, and the specific steps are:

[0105] The fibers obtained by spinning were sequentially treated with hot water at 55° C. for 20 minutes and cold water at 25° C. for 20 minutes, and then subjected to a two-stage slow cooling process to obtain gel fibers.

[0106] Comparative Example

[0107] Comparative Examples 1-6

[0108] Comparative Examples 1-6 each provide a developing seam.

[0109] The difference between the comparative example and Example 2 is that the addition amount of each component in the developing suture is specifically shown in Table 4.

[0110] Table 4 Addition amount of each component in the developing suture in Comparative Examples 1-6

[0111]

[0112]

[0113] Comparative Example 7

[0114] This comparative example provides a developing seam.

[0115] The difference between this comparative example and Example 2 is that no fatty acid is added to the developing suture.

[0116] Comparative Example 8

[0117] This comparative example provides an ultra-high molecular weight polyethylene monofilament suture. The preparation method of the ultra-high molecular weight polyethylene monofilament suture in this comparative example specifically comprises the following steps:

[0118] According to Table 1, 10 g of ultra-high molecular weight polyethylene was weighed and dispersed in 100 g of white oil. Ultrasonic treatment was performed for 2 h at an ultrasonic temperature of 40° C. and a frequency of 40 kHz to obtain a slurry.

[0119] The slurry is fed into a twin-screw extruder at a temperature of 230-250°C. After the extrudate becomes transparent, a spinneret assembly is installed for spinning.

[0120] The spun fibers were sequentially treated with 85°C hot water for 20 minutes, 55°C warm water for 20 minutes, and 25°C cold water for 20 minutes, followed by a three-stage slow cooling process to obtain gel fibers.

[0121] The gel fibers were allowed to stand at room temperature for 24 hours to allow the gel fibers to undergo phase separation and separate out the white oil;

[0122] The separated fibers were placed in an analytically pure dichloroethane extractant and subjected to ultrasonic extraction. After the extraction, the fibers were dried at 90° C. to obtain ultra-high molecular weight polyethylene monofilament sutures.

[0123] Performance testing

[0124] 1. Mechanical properties of developing sutures

[0125] The developing sutures of Examples 1-21 and Comparative Examples 1-7 and the ultra-high molecular weight polyethylene monofilament suture in Comparative Example 8 were used as test objects, and the tensile strength, tensile modulus and elongation at break of the developing sutures were tested to examine the mechanical properties of the developing sutures.

[0126] Testing method: The tensile strength of the developed seam is tested according to the test conditions of the ASTM D885 test method; the tensile modulus of the developed seam is tested according to the test conditions of the ASTM D2256 test method; and the elongation at break of the developed seam is tested according to the test conditions of the ISO2062 test method.

[0127] Test results: as shown in Table 5.

[0128] 2. Development effect of developing sutures

[0129] (1) Developed image

[0130] Four strands of the developing suture prepared in Example 2 and eight strands of the ultra-high molecular weight polyethylene monofilament suture prepared in Comparative Example 8 were braided using a braiding machine to form a braided fabric as a medical developing suture.

[0131] Place the medical sutures on A4 paper and take photos using an X-ray developer.

[0132] Test result picture: Figure 1 shown.

[0133] Through Figure 1 Observation shows that the medical developing suture prepared using the developing suture provided by the present application can present a clear and obvious image under X-ray irradiation, indicating that the formula and preparation method provided by the present application can obtain a developing suture with good developing effect.

[0134] (2) Clarity and brightness of the developed image

[0135] The developed sutures of Examples 1-21 and Comparative Examples 1-7, and the ultra-high molecular weight polyethylene monofilament suture in Comparative Example 8 were used as test objects. The sutures were placed on A4 paper and photographed using an X-ray developer to observe the clarity (clarity from high to low: high definition, relatively clear, relatively fuzzy, fuzzy) and brightness (brightness from high to low: very bright, relatively bright, relatively dark, dark) of the developed images of the sutures.

[0136] Test results: as shown in Table 5.

[0137] Table 5 Performance test results of sutures in Examples 1-21 and Comparative Examples 1-8

[0138]

[0139]

[0140] By comparing the test results of Examples 1-21 with Comparative Examples 1-8, the present application utilizes 8-12 parts by weight of ultra-high molecular weight polyethylene, 0.25-0.35 parts by weight of developer, and 0.02-0.06 parts by weight of fatty acid as the main components of the developer solution, which are then fully dispersed in 95-105 parts by weight of lubricant. The developer solution is then subjected to a preparation process comprising extrusion spinning, cooling, phase separation, and extraction drying to produce a developing suture. The developing suture exhibits a tensile strength greater than 30 cN / dTex, a tensile modulus greater than 1270 cN / dTex, and an elongation at break within the range of 2.9-4.3%. In other words, the tensile strength, tensile modulus, and elongation at break of the developing suture prepared in the present application all meet the standard performance requirements specified in ASTM F2848-10. Furthermore, the developing suture prepared in the present application can produce clear and bright images under X-ray irradiation. These test results demonstrate that the formulation and preparation method provided in the present application can produce a developing suture with excellent mechanical properties and development effects.

[0141] Comparing the test results of Examples 1-3 with Comparative Examples 1-2, when the UHMWPE addition amount is less than 8 parts, the tensile strength, tensile modulus, and elongation at break of the developing suture are low, resulting in poor mechanical properties. When the UHMWPE addition amount is greater than 12 parts, the elongation at break exceeds 4.3%, rendering the developing suture ineffective. Furthermore, the developed image of the developing suture is blurry and dark, reducing the developing effect of the developing suture. Therefore, the addition amount of UHMWPE is controlled within 8-12 parts in this application.

[0142] Comparing the test results of Examples 2, 4-5 with Comparative Examples 3-4, when the developer amount added was less than 0.25 parts, the developing effect of the developed suture was poor, while when the developer amount added was greater than 0.35 parts, the mechanical properties of the developed suture were poor. Therefore, the developer amount added in this application was controlled within the range of 0.25-0.35 parts.

[0143] Comparison of the test results of Examples 2, 6-8, and Comparative Examples 5-7 shows that the addition of fatty acids to the developing sutures significantly improves the mechanical properties and developing effect of the developing sutures compared to developing sutures without the addition of fatty acids. Furthermore, when the addition amount of fatty acids is controlled to 0.02-0.06 parts, the mechanical properties and developing effect of the developing sutures can be further improved.

[0144] By comparing the test results of Examples 2, 8-11, when the weight average molecular weight of ultra-high molecular weight polyethylene is controlled to be (3-12)×10 6 g / mol, the mechanical properties and development effect of the developed suture can be further improved. Therefore, the weight average molecular weight of the ultra-high molecular weight polyethylene is controlled within the above range in this application.

[0145] By comparing the test results of Examples 2 and 12-16, compared with selecting any one of lauric acid, palmitic acid and myristic acid as fatty acids, or selecting lauric acid and myristic acid as fatty acids, or selecting myristic acid and palmitic acid as fatty acids, the present application selects lauric acid and palmitic acid as fatty acids, which can further improve the mechanical properties and development effect of the developing suture.

[0146] At the same time, by comparing the test results of Example 2 with those of Examples 17-18, when the weight ratio of lauric acid to palmitic acid is controlled within the range of 3:(1-2), the mechanical properties and developing effect of the developing suture can be further improved. Therefore, the present application chooses to control the weight ratio of lauric acid to palmitic acid within the above range.

[0147] By comparing the test results of Example 2 with those of Examples 19-21, compared with the preparation of developing sutures by using a cold water rapid cooling process, or a hot water-cold water two-stage slow cooling process, or a warm water-cold water two-stage slow cooling process, the present application adopts a hot water-warm water-cold water three-stage cooling process to prepare developing sutures, which can further improve the mechanical properties and developing effects of the developing sutures.

[0148] 3. Biocompatibility of imaging sutures

[0149] The developing sutures of Examples 1-21 were used as test objects to test the cytotoxicity of the developing sutures and investigate the biocompatibility of the developing sutures.

[0150] Test method: Cytotoxicity test was performed in accordance with ISO 10993-5 "Biological evaluation of medical devices" Part 5 in vitro cytotoxicity test.

[0151] Test results: The developing sutures prepared in Examples 1-21 of the present application showed no reactivity, which indicates that the developing sutures provided by the present application have good biocompatibility.

[0152] Although the present invention has been described in detail above using general descriptions and specific embodiments, it will be apparent to those skilled in the art that modifications and improvements may be made based on the present invention. Therefore, such modifications and improvements, which do not depart from the spirit of the present invention, are intended to be within the scope of protection claimed herein.

Claims

1. A developer, characterized in that: The invention is composed of the following components in parts by weight: 8-12 parts of ultra-high molecular weight polyethylene; 0.25-0.35 parts of a developer; 0.02-0.06 parts of a fatty acid; and 95-105 parts of a lubricant. The fatty acid is lauric acid and palmitic acid in a weight ratio of 3:(1-2); the developer is bismuth trioxide; and the lubricant is white oil.

2. The developer according to claim 1, wherein The weight average molecular weight of the ultra-high molecular weight polyethylene is (3-12)×10 6 g / mol.

3. Use of the developer according to any one of claims 1 to 2 in medical developing materials.

4. A developing suture, characterized in that: The developed seam line is prepared using the developer according to any one of claims 1 to 2.

5. The method for preparing a developing suture according to claim 4, wherein: The specific steps include: Dispersing the ultra-high molecular weight polyethylene in the lubricant, then adding the bismuth trioxide and the fatty acid, and uniformly mixing the components with the aid of ultrasound to obtain a mixed slurry; The mixed slurry is extruded, spun, and cooled to obtain gel fiber; the cooling is slow cooling, specifically comprising the following steps: cooling the spun fiber in three stages: hot water, warm water, and cold water; the hot water temperature is 80-90°C; the warm water temperature is 50-60°C; and the cold water temperature is 20-30°C; Allowing the jelly fibers to stand at room temperature to phase separate the lubricant; The separated fibers are placed in an extractant, subjected to ultrasonic extraction, and then dried to obtain the developed suture.

6. The method for preparing a developing suture according to claim 5, characterized in that: The extractant is selected from at least one of petroleum ether, ethyl acetate and dichloromethane.

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