A multi-media aseptic transmission control system and filling machine supporting system

Abstract

The present invention discloses a multi-media aseptic transmission control system and a filling machine supporting system. The multi-media aseptic transmission control system is provided with a dry gas transmission unit for filtering and sterilizing dry gas, a liquid and steam transmission unit for cooling liquid or filtering steam, and a cleaning agent transmission unit for filtering and sterilizing cleaning agent. The output interface unit is respectively connected to the dry gas transmission unit, the liquid and steam transmission unit, and the cleaning agent transmission unit to receive and output dry gas, liquid, steam and cleaning agent to the outside. The control unit is respectively electrically connected to the dry gas transmission unit, the liquid and steam transmission unit, the cleaning agent transmission unit, and the output interface unit to control the working status of each unit. The multi-media aseptic transmission control system solves the technical problem in the related art that the transportation of cleaning medium to a filling machine system with a CIP / SIP function easily causes the interior to be contaminated by the external environment, thereby causing the cleanliness of the device to fail to meet production requirements.

Description

Technical Field

[0001] The present invention relates to the technical field of medium transmission, and in particular to a multi-media aseptic transmission control system and a filling machine supporting system. Background Art

[0002] In the production and manufacturing fields of pharmaceuticals, food, etc., the cleanliness of production equipment must be strictly guaranteed. Therefore, the production equipment must be easy to clean and maintain, and when the equipment is cleaned, its interior must maintain a high degree of sterile isolation from the external environment to prevent the interior of the equipment from being contaminated by the external environment. For example, the filling machine used in pharmaceutical production requires the input of multiple media when implementing CIP (cleaning in place) and SIP (sterilization in place) functions. However, in the relevant technology, there is no unified supporting system to transport these media to the filling machine. Sometimes, manual participation in the transmission of media is even required, which can easily lead to contamination of the filling machine by the external environment, thereby causing it to fail to meet the standards for pharmaceutical production.

[0003] Therefore, how to overcome the problem in the related art that the device is easily contaminated by the external environment when the medium is transported to the device for cleaning has become a technical problem that needs to be solved by those skilled in the art. Summary of the Invention

[0004] The embodiment of the present invention proposes a multi-media aseptic transmission control system and a filling machine supporting system to solve the technical problem in the related art that when the cleaning medium is transported to the interior of the device, the interior of the device is easily contaminated by the external environment, which in turn causes the cleanliness of the device to fail to meet production requirements.

[0005] In a first aspect, an embodiment of the present invention provides a multi-media aseptic transmission control system, comprising:

[0006] A dry gas transmission unit, used for filtering and sterilizing the dry gas to be transmitted;

[0007] Liquid and steam transmission unit, used for filtering and outputting the liquid to be transmitted after cooling, or for filtering and outputting the steam to be transmitted;

[0008] The cleaning agent transmission unit is used to filter and sterilize the cleaning agent to be transmitted before outputting it;

[0009] an output interface unit, connected to the dry gas transmission unit, the liquid and steam transmission unit, and the cleaning agent transmission unit, respectively, for receiving and outputting the dry gas, the liquid, the steam, or the cleaning agent;

[0010] The control unit is electrically connected to the drying gas transmission unit, the liquid and steam transmission unit, the cleaning agent transmission unit and the output unit interface respectively, and is used to control the working status of each unit.

[0011] The multi-media aseptic transmission control system according to the embodiment of the present invention has at least the following beneficial effects:

[0012] In an embodiment of the present invention, a multi-media aseptic transmission control system is provided with a dry gas transmission unit, a liquid and steam transmission unit, a cleaning agent transmission unit, an output interface unit and a control unit; wherein the dry gas transmission unit is used to filter and sterilize the dry gas to be transmitted, the liquid and steam transmission unit is used to filter and output the liquid to be transmitted after cooling, or is used to filter and output the steam to be transmitted, the cleaning agent transmission unit is used to filter and sterilize the cleaning agent to be transmitted and output, the output interface unit is respectively connected to the dry gas transmission unit, the liquid and steam transmission unit, and the cleaning agent transmission unit, and is used to receive and output dry gas, liquid, steam and cleaning agent to the outside, the control unit is respectively electrically connected to the dry gas transmission unit, the liquid and steam transmission unit, the cleaning agent transmission unit, and the output interface unit, and is used to control the working status of each unit; it solves the technical problem in the related art that when the cleaning medium is transported to the interior of the device, the interior of the device is easily contaminated by the external environment, which in turn causes the cleanliness of the device to fail to meet production requirements, and provides a safe, sterile, and automated multi-media aseptic transmission control system.

[0013] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the dry gas transmission unit includes a plurality of first control valves, a first filter and a second filter;

[0014] A plurality of the first control valves, the first filter and the second filter are electrically connected to the control unit respectively and are controlled by the control unit to filter and sterilize the dry gas.

[0015] According to some other embodiments of the multimedia aseptic transmission control system of the present invention, the liquid and steam transmission unit includes a plurality of second control valves, a cooling device, a third filter and a fourth filter;

[0016] A plurality of the second control valves, the cooling device, the third filter and the fourth filter are electrically connected to the control unit respectively, and are all controlled by the control unit to cool the liquid or filter the steam.

[0017] According to other embodiments of the multi-media aseptic transmission control system of the present invention, the cooling device includes a double-tube sheet heat exchanger, a back-blowing compressed air pipeline, a chilled water supply pipeline, and a chilled water return pipeline;

[0018] The back-blowing compressed air pipeline, the chilled water supply pipeline, and the chilled water return pipeline are respectively connected to the double-tube plate heat exchanger;

[0019] The backflush compressed air pipeline, the chilled water supply pipeline, the chilled water return pipeline, and the double-tube sheet heat exchanger are respectively electrically connected to the control unit and are all controlled by the control unit to drain the chilled water in the double-tube sheet heat exchanger so as to sterilize and heat the pipelines of the double-tube sheet heat exchanger.

[0020] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the cleaning agent transmission unit includes a plurality of third control valves and a fifth filter;

[0021] The plurality of third control valves and the fifth filter are electrically connected to the control unit respectively and are controlled by the control unit to filter and transmit the cleaning agent.

[0022] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the output interface unit includes a pneumatically regulated diaphragm valve;

[0023] The pneumatic regulating diaphragm valve is electrically connected to the control unit and is controlled by the control unit to output the drying gas, the liquid, the steam or the cleaning agent to the outside.

[0024] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the dry gas transmission unit further includes a water storage tank and a water storage tank filter;

[0025] The multiple input ports of the water storage tank are respectively connected to the input end of the first filter, the output end of the first filter, and the output end of the liquid and steam transfer unit;

[0026] The water tank filter is arranged on the air port of the water tank.

[0027] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the multi-media aseptic transmission control system further includes a drainage unit;

[0028] The multiple input ports of the drainage unit are respectively connected to the discharge port of the dry gas transmission unit and the discharge port of the liquid and steam transmission unit;

[0029] The drainage unit is electrically connected to the control unit, and the working state of the drainage unit is controlled by the control unit.

[0030] According to some other embodiments of the multi-media aseptic transmission control system of the present invention, the dry gas includes one or more of compressed air and nitrogen;

[0031] The liquid is water for injection;

[0032] The cleaning agent is alkaline solution.

[0033] In a second aspect, an embodiment of the present invention provides a filling machine supporting system with CIP / SIP function, which includes: a filling machine and the multi-media aseptic transmission control system as described above, wherein:

[0034] The feed port of the filling machine is connected to the output interface unit of the multi-media aseptic transmission control system. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a module diagram of a specific embodiment of a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0036] Figure 2 This is a schematic structural diagram of a specific embodiment of a dry gas transmission unit in a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0037] Figure 3 This is a structural diagram of a specific embodiment of a liquid and steam transmission unit in a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0038] Figure 4 This is a structural diagram of a specific embodiment of a cleaning agent transmission unit in a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0039] Figure 5 This is a structural diagram of a specific embodiment of an output interface unit in a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0040] Figure 6 This is a schematic structural diagram of a specific embodiment of a multi-media aseptic transmission control system having a water storage tank and a water storage tank filter according to an embodiment of the present invention;

[0041] Figure 7 This is a structural diagram of a specific embodiment of a drainage unit in a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0042] Figure 8 This is a complete structural diagram of a specific embodiment of a multi-media aseptic transmission control system according to an embodiment of the present invention;

[0043] Figure 9 This is a module block diagram of a specific embodiment of a filling machine supporting system with CIP / SIP function according to an embodiment of the present invention. DETAILED DESCRIPTION

[0044] The following will provide a clear and complete description of the concept of the invention and the technical effects produced by the invention in conjunction with the embodiments, so as to fully understand the purpose, features and effects of the invention. Obviously, the embodiments described are only part of the embodiments of the invention, not all of them. Based on the embodiments of the invention, other embodiments obtained by those skilled in the art without inventive effort shall fall within the scope of protection of the invention.

[0045] In the description of the embodiments of the present invention, if the word "several" is mentioned, it means more than one; if the word "plurality" is mentioned, it means more than two; if the word "greater than," "less than," or "exceeds," it should be understood as excluding the number itself; if the word "above," "below," or "within" is mentioned, it should be understood as including the number itself. If the word "first" or "second" is mentioned, it should be understood as distinguishing technical features and should not be understood as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0046] Reference Figure 1 An embodiment of the present invention provides a multi-media aseptic transmission control system, comprising a dry gas transmission unit, a liquid and vapor transmission unit, a cleaning agent transmission unit, an output interface unit, and a control unit. The dry gas transmission unit, the liquid and vapor transmission unit, and the cleaning agent transmission unit are each connected to the output interface unit via a pipeline. The control unit is electrically connected to the dry gas transmission unit, the liquid and vapor transmission unit, the cleaning agent transmission unit, and the output interface unit. In this embodiment, the dry gas transmission unit is controlled by the control unit and is configured to filter and sterilize the dry gas to be transmitted before outputting it. The liquid and vapor transmission unit is controlled by the control unit and is configured to cool the liquid to be transmitted before outputting it, or to filter and process the steam to be transmitted before outputting it. The cleaning agent transmission unit is controlled by the control unit and is configured to filter and sterilize the cleaning agent to be transmitted before outputting it. The output interface unit is controlled by the control unit and is configured to transmit the received dry gas, liquid, vapor, or cleaning agent to the outside. In this embodiment, each transmission unit sterilizes or filters the medium to be transmitted before outputting it to the target device through the output interface unit. This ensures that the internal environment of the target device is not contaminated when the target device receives these media. It solves the technical problem in related technologies that when transporting cleaning media to the interior of the device, the interior of the device is easily contaminated by the external environment, which in turn causes the cleanliness of the device to fail to meet production and manufacturing requirements. It provides a safe, sterile, and automated multi-media sterile transmission control system.

[0047] Reference Figure 2In some embodiments, the dry gas transmission unit includes a first filter 1000, a second filter 1100 and a plurality of first control valves (eg Figure 2 In the embodiment, the plurality of first control valves include control valves 100 to 114); wherein the number and type of the first control valves can be set according to actual design requirements. In this embodiment, the dry gas includes one or more of compressed air and nitrogen, wherein the compressed air enters through the control valve 100 and is filtered and sterilized by the first filter 1000 and the second filter 1100 before being output from the output port of the second filter 1100; the nitrogen enters through the control valve 101 and is filtered and sterilized by the first filter 1000 and the second filter 1100 before being output from the output port of the second filter 1100; the first filter 1000 and the second filter 1100 are both equipped with a 0.22 μm sterilizing filter element. In this embodiment, the control valves 100 to 114, the first filter 1000, and the second filter 1100 are respectively electrically connected to the control unit, and their operating states are all controlled by the control unit. In this embodiment, by providing the control valve 113 and the steam trap 114, the gas pipeline can be sterilized online.

[0048] Reference Figure 3 In some embodiments, the liquid and vapor transfer unit includes a cooling device, a third filter 2000, a fourth filter 2200 and a plurality of second control valves (such as Figure 3As shown, the plurality of second control valves include control valve 218, control valve 219, control valve 220, control valve 221, Y-type filter 222, and control valve 223. In this embodiment, the cooling device includes a double-tube sheet heat exchanger 2100, a backflush compressed air pipeline, a chilled water supply pipeline, and a chilled water return pipeline. The backflush compressed air pipeline includes a pipeline consisting of control valve 215, control valve 216, and control valve 217; the chilled water return pipeline includes a pipeline consisting of control valve 218, control valve 219, and control valve 220; and the chilled water supply pipeline includes a pipeline consisting of control valve 221, Y-type filter 222, and control valve 223. In this embodiment, the liquid to be transported enters through control valve 200. If the liquid needs to be cooled, it enters double-tube sheet heat exchanger 2100 through control valve 204 for cooling before being output. The cooled liquid can be filtered through fourth filter 2200 and output through control valve 213. Gas and steam can be output through the bypass formed by control valves 208 and 214. While the double-tube sheet heat exchanger 2100 is cooling the liquid to be transported, chilled water is injected into the chilled water supply line. After passing through the double-tube sheet heat exchanger 2100, it flows out through the chilled water return line. After cooling the liquid to be transported, the temperature of the cooled liquid can be controlled through valve 218. Compressed air is injected into the backflush compressed air line to blow the chilled water remaining in the double-tube sheet heat exchanger 2100 out through control valve 224, thereby sterilizing and heating the liquid lines of the double-tube sheet heat exchanger. In this embodiment, the steam to be transmitted is filtered by the third filter 2000, then bypasses the double-tube sheet heat exchanger 2100 through the bypass composed of the control valve 203 and the control valve 206, and is then output through the control valve 208 and the control valve 214. In this embodiment, in order to save the laying of the medium transmission pipeline, the output end of the dry gas transmission unit (refer to Figure 2 , i.e., the output end of the second filter 1100) is connected to the control valve 201 in the liquid and vapor transfer unit. This allows the dry gas, after passing through the first and second filters 1000 and 1100, to be output to the output interface unit via the pipeline in the liquid and vapor transfer unit. In this embodiment, the third filter 2000, double-tube sheet heat exchanger 2100, fourth filter 2200, and control valves 200 through 213 are each electrically connected to the control unit, and their operating states are controlled by the control unit. The liquid to be transferred is water for injection. Obviously, the number and type of second control valves can be set according to actual design requirements.

[0049] Reference Figure 4In some embodiments, the cleaning agent transmission unit includes a fifth filter 3000 and several third control valves, wherein the several third control valves include control valves 300 to control valves 303. In this embodiment, the type and quantity of the third control valves can be set according to actual needs. In this embodiment, the cleaning agent to be transmitted enters the fifth filter 3000 through the control valve 300 for sterilization filtration, then passes through the control valve 301 and the control valve 302, and finally enters the output interface unit through the control valve 303 and is output to the target device. In this embodiment, the fifth filter 3000 is equipped with a 0.22um sterilization filter element, and the fifth filter 3000 and the control valves 300 to the control valves 303 are electrically connected to the control unit respectively, and their working states are all controlled by the control unit, and then the cleaning agent to be transmitted is filtered and sterilized and then output. In other embodiments, the cleaning agent to be transmitted is alkaline solution.

[0050] Reference Figure 5 In some embodiments, the output interface unit includes a pneumatic regulating diaphragm valve 400, a control valve 401 and a pressure reducing valve 402. Figure 3 The pressure reducing valve 402 is also connected to the control valve 213 and the control valve 214 respectively, and is used to receive the dry gas from the dry gas transmission unit, or to receive the liquid or steam from the liquid and steam transmission unit, and adjust it to a suitable pressure for output. After passing through the control valve 401, it is output to the target device through the output port of the pneumatically adjustable diaphragm valve 400. Figure 4 Control valve 303 is connected between control valve 401 and pneumatically controlled diaphragm valve 400. After receiving cleaning agent from the cleaning agent delivery unit, pneumatically controlled diaphragm valve 400 delivers the cleaning agent to the target device through its output port. In this embodiment, pneumatically controlled diaphragm valve 400 and control valve 401 are each electrically connected to a control unit, and their operating states are controlled by the control unit.

[0051] Reference Figure 6 In this embodiment, combined with Figure 2In order to prevent the downstream pipeline of the first filter 1000 from being contaminated by the external environment when performing an in-situ integrity test on the first filter 1000 after SIP, the dry gas transmission unit also includes a water tank 5000, a water tank respirator 5100, and control valves 500 to 503. Among them, the first input port 504 of the water tank 5000 is connected to the input port of the first filter 1000 through the control valve 105, the second input port 505 of the water tank 5000 is connected to the output port of the first filter 1000 through the control valve 109, and the water tank filter 5100 is connected to the exhaust port of the water tank 5000 through the control valve 502. In addition, the water tank 5000 is also provided with a low liquid level probe 507 and a high liquid level probe 508 for detecting the liquid level information in the water tank 5000, and deciding whether to discharge the liquid in the water tank 5000 based on the liquid level information, and using sterile liquid for isolation to avoid contamination of the water tank during the discharge process. Combined with Figure 3 The control valve 212 in the liquid and vapor transfer unit is connected to the third input port 506 of the water tank 5000, enabling post-SIP in-place integrity testing of the fourth filter 2200. The sterile liquid being tested flows into the water tank 5000 through the control valve 212, where it is isolated by the sterile liquid to prevent contamination of the water tank during the discharge process. Furthermore, because the dry gas transfer unit is connected to the control valve 201 in the liquid and vapor transfer unit via the output of the second filter 2000, steam can be introduced into the water tank 5000 when the control valves 104 and 105 are opened by the control unit, sterilizing the water tank 5000 and the water tank respirator 5100. In this embodiment, the water tank filter 5100 and the control valves 500 to 503 are electrically connected to the control unit respectively, and their working status is controlled by the control unit. The liquid level information obtained by the low liquid level probe 507 and the high liquid level probe 508 is sent to the control unit. The control unit controls the control valve 500 according to the liquid level information and decides whether to drain water out.

[0052] Reference Figure 7 In some embodiments, the multi-media aseptic transmission control system further includes a drainage unit, wherein the drainage unit includes input ports 611 to 618, drain valves 601 to 607, control valves 608, control valves 609, and a main drain pipe 610; wherein the main drain pipe 610 is provided with a drain port for discharging the media received by each input port. Figure 2 and Figure 6In this embodiment, the input port 611 is connected to the control valve 107, the input port 612 is connected to the control valve 112, and the input port 617 is connected to the control valve 114, thereby achieving online sterilization of the gas filter. The input port 614 is connected to the control valve 503, the input port 615 is connected to the control valve 501, and the input port 616 is connected to the control valve 500, thereby achieving online sterilization of the water tank and the water tank respirator, thereby achieving online sterilization of the gas filter and the water tank respirator. Figure 3 Input port 613 is connected to control valve 211, and input port 618 is connected to control valve 213 (and also to control valve 214), thereby achieving online sterilization of the pipelines of the liquid and steam transfer units. In this embodiment, the control valves are all controlled by the control unit, thereby changing their working state and performing online sterilization of the relevant pipelines and objects to meet sterility requirements.

[0053] Reference Figure 8 , Figure 8 This is a schematic diagram of the overall structure of a multi-media aseptic transmission control system according to an embodiment of the present invention. The composition and connection relationship of each unit in the multi-media aseptic transmission control system refer to the description in the above embodiments and are not repeated here.

[0054] Reference Figure 9 The embodiment of the present invention provides a sterile medium transmission system for a filling machine with CIP / SIP function, which includes the multi-media sterile transmission control system in any of the above embodiments; wherein the filling machine has CIP / SIP function, and the feed port of the filling machine is connected to the output interface unit in the multi-media sterile transmission control system. That is, combined with Figure 5 The feed port of the filling machine is connected to the pneumatically controlled diaphragm valve 400, so that the dry gas transmitted in the dry gas transmission unit or the liquid, steam transmitted in the steam transmission unit or the cleaning agent transmitted in the cleaning agent transmission unit will be input into the filling machine through the pneumatically controlled diaphragm valve 400, so that the temperature, pressure and flow of the dry gas, liquid, steam or cleaning agent can be controlled during transmission to meet the CIP / SIP requirements of the filling machine.

[0055] While the embodiments of the present invention have been described in detail above with reference to the accompanying drawings, the present invention is not limited to the embodiments described above. Various modifications may be made within the scope of knowledge possessed by a person skilled in the art without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof may be combined with one another unless there is a conflict.

Claims

1. A multi-media aseptic transmission control system, characterized in that: include: A dry gas transmission unit, used for filtering and sterilizing the dry gas to be transmitted; Liquid and steam transmission unit, used for filtering and outputting the liquid to be transmitted after cooling, or for filtering and outputting the steam to be transmitted; The cleaning agent transmission unit is used to filter and sterilize the cleaning agent to be transmitted before outputting it; an output interface unit, connected to the dry gas transmission unit, the liquid and steam transmission unit, and the cleaning agent transmission unit, respectively, for receiving and outputting the dry gas, the liquid, the steam, or the cleaning agent; a control unit, electrically connected to the drying gas transmission unit, the liquid and steam transmission unit, the cleaning agent transmission unit, and the output interface unit, respectively, for controlling the working state of each unit; The dry gas transmission unit includes a plurality of first control valves, a first filter, and a second filter; the plurality of first control valves, the first filter, and the second filter are electrically connected to the control unit, and are all controlled by the control unit to filter and sterilize the dry gas; the liquid and steam transmission unit includes a plurality of second control valves, a cooling device, a third filter, and a fourth filter; the plurality of second control valves, the cooling device, the third filter, and the fourth filter are electrically connected to the control unit, and are all controlled by the control unit to cool the liquid or filter the steam; The cooling device includes a double-tube-sheet heat exchanger, a back-blowing compressed air pipeline, a chilled water supply pipeline, and a chilled water return pipeline; the back-blowing compressed air pipeline, the chilled water supply pipeline, and the chilled water return pipeline are respectively connected to the double-tube-sheet heat exchanger; the back-blowing compressed air pipeline, the chilled water supply pipeline, the chilled water return pipeline, and the double-tube-sheet heat exchanger are respectively electrically connected to the control unit and are all controlled by the control unit to drain the chilled water in the double-tube-sheet heat exchanger so as to sterilize and heat the pipelines of the double-tube-sheet heat exchanger; The dry gas transmission unit further includes a water storage tank and a water storage tank filter; a plurality of input ports of the water storage tank are respectively connected to the input end of the first filter, the output end of the first filter, and the output end of the liquid and vapor transmission unit; the water storage tank filter is disposed on the gas port of the water storage tank; The multi-media aseptic transmission control system also includes a drainage unit; the multiple input ports of the drainage unit are respectively connected to the discharge port of the dry gas transmission unit and the discharge port of the liquid and steam transmission unit; the drainage unit is electrically connected to the control unit, and the working state of the drainage unit is controlled by the control unit.

2. The multi-media aseptic transmission control system according to claim 1, characterized in that: The cleaning agent transmission unit includes a plurality of third control valves and a fifth filter; The plurality of third control valves and the fifth filter are electrically connected to the control unit respectively and are controlled by the control unit to filter and transmit the cleaning agent.

3. The multi-media aseptic transmission control system according to claim 2, characterized in that: The output interface unit includes a pneumatically regulated diaphragm valve; The pneumatic regulating diaphragm valve is electrically connected to the control unit and is controlled by the control unit to output the drying gas, the liquid, the steam or the cleaning agent to the outside.

4. The multi-media aseptic transmission control system according to claim 1, characterized in that: The drying gas includes one or more of compressed air and nitrogen; The liquid is water for injection; The cleaning agent is alkaline solution.

5. A filling machine supporting system with CIP / SIP function, characterized in that: It comprises a filling machine and a multi-media aseptic transmission control system according to any one of claims 1 to 4; The feed port of the filling machine is connected to the output interface unit of the multi-media aseptic transmission control system.

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