An essence containing serum albumin and a preparation method thereof

Abstract

This application relates to the field of essence, and more specifically, it relates to an essence containing serum albumin and a preparation method thereof. An essence containing serum albumin, by mass percentage, comprises the following components: Phase A: water, 1-10% humectant, 0-1% antioxidant, 0-2% thickener; Phase B: 0.5-3% sturgeon roe extract, 0.05-0.5% ubiquinone, 0-3% skin conditioner, 0.1-5% solvent, 0.1-0.5% serum albumin; water makes up the balance to 100%; The preparation method is: Mix various raw materials of Phase A evenly to obtain Phase A; Mix various raw materials of Phase A and Phase B evenly to obtain the finished product. This application has the advantages of rapid wrinkle removal and firming.

Description

Technical Field

[0001] The present application relates to the field of essence, and more specifically, it relates to an essence containing serum albumin and a preparation method thereof. Background Art

[0002] Generally, after the age of 25, the state of the face will be inferior to before, and many people begin to have wrinkles. Wrinkles are divided into true wrinkles and false wrinkles. True wrinkles are deep wrinkles caused by skin aging, and false wrinkles are superficial wrinkles formed due to long-term excessive contraction of the mimetic muscles. Long-term excessive contraction of the mimetic muscles will cause the skin elastic fibers to break, changing from false wrinkles to true wrinkles, which are difficult to eliminate.

[0003] In order to relieve the wrinkles on the skin surface, many products have emerged on the market, such as daily eye care products like eye cream, eye gel, and eye essence. These are mostly basic care products with mild properties and require long-term continuous use to be effective.

[0004] Modern people have a fast-paced life and often stay up late or all night, resulting in many false wrinkles and fine lines on the face the next day. Most of these false wrinkles and fine lines that suddenly appear due to excessive fatigue and other conditions cannot be quickly eliminated by the above-mentioned basic care products. Therefore, there is still room for improvement. Summary of the Invention

[0005] In order to quickly remove wrinkles and tighten the skin, the present application provides an essence containing serum albumin and a preparation method thereof.

[0006] In the first aspect, the present application provides an essence containing serum albumin, adopting the following technical solution: An essence containing serum albumin, by mass percentage, includes the following components:

[0007] Phase A: water, 1 - 10% humectant, 0 - 1% antioxidant, 0 - 2% thickener;

[0008] Phase B: 0.5 - 3% sturgeon roe extract, 0.05 - 0.5% ubiquinone, 0 - 3% skin conditioner, 0.1 - 5% solvent, 0.1 - 0.5% serum albumin;

[0009] Water makes up the balance to 100%.

[0010] By adopting the above technical solution, under the combined action of sturgeon roe extract, ubiquinone, and serum albumin, interactions occur, enabling the three to form a special structure and create a special microenvironment. This special structure is conducive to enhancing polarity, weakening hydrophobicity, and improving hydrophilicity, resulting in a more thorough mixing effect in the essence with water as the main carrier. After the user completes basic skincare steps such as cleansing the face and spraying toner, when using the essence provided by this application while there is still toner on the face, due to the good hydrophilicity of this special structure, the essence can quickly spread and cover all parts of the face evenly. The essence forms a dry moisturizing film on the face, and when the moisturizing film dries, it can also tighten the skin, especially having an obvious lifting effect on fine wrinkles on the eyes and face, thus achieving a good anti-wrinkle and firming effect.

[0011] Moreover, during actual research and development, it was found that the special structure formed by the combination of sturgeon roe extract, ubiquinone, and serum albumin can also bind to some harmful metal ions on the skin surface, thereby effectively reducing the irritation caused by harmful metal ions to the skin and alleviating a series of discomforts such as itching, redness, and stinging caused by the irritation.

[0012] During actual testing, it was found that applying the essence provided by this application can significantly relieve the number and length of wrinkles in about half an hour.

[0013] Preferably, the mass ratio of the sturgeon roe extract, ubiquinone, and serum albumin is 1:(0.05 - 0.15):(0.1 - 0.2), based on the mass of the sturgeon roe extract.

[0014] When the mass ratio of the sturgeon roe extract, ubiquinone, and serum albumin is inappropriate, metal ions are likely to affect the stability of the formed special structure, compete for some special binding sites, resulting in the disappearance of the special structure, the inability to have good hydrophilicity, and further affecting the integrity of the moisturizing film, thus reducing the lifting and moisturizing effects.

[0015] By adopting the above technical solution, further limiting the usage ratio of the sturgeon roe extract, ubiquinone, and serum albumin, under this limitation, the stability of the formed special structure can be guaranteed to the greatest extent, and it can bind to metal ions more quickly and stably.

[0016] Preferably, the solvent includes an alcohol solvent and water.

[0017] Preferably, the alcohol solvent is one or a mixture of 1,2 - hexanediol, ethanol, pentylene glycol, hexylene glycol, and butylene glycol.

[0018] Preferably, the alcohol solvent is 1,2 - hexanediol. By mass percentage, 1,2 - hexanediol accounts for 0.1 - 1% of the total essence, and water accounts for 1 - 3% of the total essence.

[0019] Preferably, the humectant comprises one or more of sodium hyaluronate, butylene glycol, allantoin, 1,2 - hexanediol, and glycerol.

[0020] By adopting the above - mentioned technical solution, using the humectant can effectively moisturize the skin and maintain the skin's moisture and luster.

[0021] Preferably, the humectant is sodium hyaluronate, butylene glycol, and allantoin. By mass percentage, sodium hyaluronate accounts for 0.1 - 0.5% of the total essence, butylene glycol accounts for 3 - 6% of the total essence, and allantoin accounts for 0.05 - 0.3% of the total essence.

[0022] Preferably, the sodium hyaluronate comprises one or more of sodium hyaluronate with a molecular weight of 2 million and sodium hyaluronate with a molecular weight of 1.2 million.

[0023] Preferably, the sodium hyaluronate is sodium hyaluronate with a molecular weight of 2 million and sodium hyaluronate with a molecular weight of 1.2 million, and the mass ratio of sodium hyaluronate with a molecular weight of 2 million to sodium hyaluronate with a molecular weight of 1.2 million is 1:1.

[0024] Although the special structures of sturgeon roe extract, ubiquinone, and serum albumin can form a moisture - retaining film, the water - locking effect of this moisture - retaining film is relatively obvious, and the water - replenishing effect still needs to be improved.

[0025] Therefore, by adopting the above - mentioned technical solution, further defining the types and usage ratios of the humectant makes the essence have good adsorption and affinity on the face, and can efficiently moisturize the skin. The preferably selected humectant for efficient water replenishment and the moisture - retaining film with remarkable water - locking ability cooperate together to maintain the dynamic balance of moisture on the skin surface, long - term keep a relatively high moisture content, and show a better skin state.

[0026] Preferably, the thickener comprises one or more of ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl cellulose, and carbomer.

[0027] The use of the thickener can prevent droplet gelation, make the system have a good consistency, and improve the stability of the essence.

[0028] Preferably, the skin conditioner comprises one or more of maltodextrin, talc powder, and bentonite.

[0029] Preferably, the skin conditioner is maltodextrin, the thickener is ammonium acryloyldimethyltaurate / VP copolymer, and the mass ratio of maltodextrin to ammonium acryloyldimethyltaurate / VP copolymer is 1:(0.2 - 0.4) based on the mass of maltodextrin.

[0030] By adopting the above technical solution, with the special combination of maltodextrin and acryloyldimethyltaurate / VP copolymer, the viscosity of the essence is further adjusted, enabling the essence to quickly stay on the face without making the face sticky, facilitating the rapid and stable formation of a moisturizing film, reducing the irritation felt by the skin, and giving users a good experience.

[0031] In a second aspect, the present application provides a method for preparing an essence containing serum albumin, adopting the following technical solution:

[0032] A method for preparing an essence containing serum albumin includes the following steps:

[0033] Mix all the raw materials in phase A evenly to obtain phase A;

[0034] Mix all the raw materials in phases A and B until uniform to obtain the finished product.

[0035] Preferably, a method for preparing an essence containing serum albumin includes the following steps:

[0036] Mix all the raw materials in phase A, heat up to 80 - 85 °C, homogenize and stir until dissolved evenly, and keep warm for 5 - 15 minutes to obtain phase A;

[0037] Start cooling. After cooling to 40 - 45 °C, add all the raw materials in phase B to phase A, stir until dissolved evenly to obtain the finished product.

[0038] By adopting the above technical solution, mixing the raw materials in a specific mixing order and temperature provides good conditions for the special combination of various raw materials.

[0039] In summary, the present application has the following beneficial effects:

[0040] 1. With the combined action of sturgeon roe extraction, ubiquinone, and serum albumin, they interact with each other to form a special structure, creating a special microenvironment; weakening hydrophobicity and enhancing hydrophilicity, achieving a more sufficient mixing effect in the essence with water as the main carrier.

[0041] After users complete basic tasks such as facial cleansing and spraying toner, when using the essence provided by the present application while still having toner on the face, the essence can quickly spread and cover all parts of the face evenly.

[0042] 2. The essence provided by the present application forms a dry moisturizing film on the face, and the moisturizing film can tighten the skin when drying, especially having an obvious lifting effect on fine wrinkles on the eyes and face, thus achieving a good anti-wrinkle and firming effect.

[0043] 3. The special structure formed by the combination of sturgeon roe extract, ubiquinone, and serum albumin can also bind to some harmful metal ions on the skin surface, thereby effectively reducing the irritation caused by harmful metal ions to the skin and alleviating a series of discomforts such as itching, redness, and stinging caused by the irritation. Description of the Drawings

[0044] Figure 1 It is a picture taken of the left eye of a volunteer using a skin imager, and the corresponding product used is that of Example 6.

[0045] The first row is the picture taken of the volunteer before using the product. The left picture in the first row is the original picture, and the right picture in the first row is the processed picture for easy observation after post-processing.

[0046] The second row is the picture taken of the volunteer half an hour after using the product. The left picture in the second row is the original picture, and the right picture in the second row is the processed picture for easy observation after post-processing.

[0047] Figure 2 It is a picture taken of the right eye of a volunteer using a skin imager, and the corresponding product used is that of Example 6.

[0048] The first row is the picture taken of the volunteer before using the product. The left picture in the first row is the original picture, and the right picture in the first row is the processed picture for easy observation after post-processing.

[0049] The second row is the picture taken of the volunteer half an hour after using the product. The left picture in the second row is the original picture, and the right picture in the second row is the processed picture for easy observation after post-processing. Detailed Embodiments

[0050] The following further elaborates on this application in conjunction with the drawings and embodiments.

[0051] All products used in the following examples and comparative examples are commercially available products.

[0052] Examples

[0053] Example 1

[0054] An essence containing serum albumin, comprising the following components:

[0055] Component A: water, humectant, antioxidant, thickener.

[0056] Component B: sturgeon roe extract, ubiquinone, skin conditioner, solvent, serum albumin.

[0057] The humectant is sodium hyaluronate, butylene glycol, and allantoin, and the sodium hyaluronate is sodium hyaluronate with a molecular weight of 2 million.

[0058] The antioxidant is p - hydroxyacetophenone.

[0059] The thickener is acryloyldimethyltaurate / VP copolymer.

[0060] The solvent is an alcohol solvent and water, and the alcohol solvent is 1,2 - hexanediol.

[0061] The skin conditioner is maltodextrin.

[0062] The sturgeon roe extract and serum albumin are purchased from Guangzhou Xufan Trading Co., Ltd.

[0063] The embodiment of the present application also discloses a preparation method of a serum albumin-containing essence, including the following steps: Step 1: Weigh various raw materials in phase A into a reaction kettle, heat up to 85 °C, homogenize and stir until dissolved uniformly, and keep warm for 10 minutes to obtain phase A.

[0064] Step 2: Start to cool down. When the temperature drops to 45 °C, add various raw materials in phase B, stir until dissolved uniformly, and then discharge to obtain the finished product.

[0065] Example 2

[0066] A serum albumin-containing essence, different from Example 1 in that the mass ratio of sturgeon roe extract, ubiquinone, and serum albumin is 1:0.05:0.2. That is, the usage amount of sturgeon roe extract is 1 kg, the usage amount of ubiquinone is 0.05 kg, the usage amount of serum albumin is 0.2 kg, and the usage amount of water in phase A is 89.46 kg.

[0067] For specific dosage details, see Table 1.

[0068] Example 3

[0069] A serum albumin-containing essence, different from Example 1 in that the mass ratio of sturgeon roe extract, ubiquinone, and serum albumin is 1:0.15:0.1. That is, the usage amount of sturgeon roe extract is 1 kg, the usage amount of ubiquinone is 0.15 kg, the usage amount of serum albumin is 0.1 kg, and the usage amount of water in phase A is 89.46 kg.

[0070] For specific dosage details, see Table 1.

[0071] Table 1

[0072]

[0073]

[0074] Example 4

[0075] A serum albumin-containing essence, different from Example 1 in that the usage amount of sturgeon roe extract is 0.5 kg, the usage amount of ubiquinone is 0.26 kg, and the usage amount of serum albumin is 0.5 kg.

[0076] Example 5

[0077] A serum albumin-containing essence, which is different from Example 1 in that the usage amount of sodium hyaluronate is 2.5 kg, the usage amount of butylene glycol is 0.3 kg, and the usage amount of allantoin is 2.5 kg.

[0078] Example 6

[0079] A serum albumin-containing essence, which is different from Example 1 in that the sodium hyaluronate is sodium hyaluronate of 2 million and sodium hyaluronate of 1.2 million, the mass ratio of sodium hyaluronate of 2 million to sodium hyaluronate of 1.2 million is 1:1, the usage amount of sodium hyaluronate of 2 million is 0.1 kg, and the usage amount of sodium hyaluronate of 1.2 million is 0.1 kg.

[0080] Example 7

[0081] A serum albumin-containing essence, which is different from Example 1 in that the mass ratio of maltodextrin to acryloyldimethyltaurine / VP copolymer is 1:0.2, that is, the usage amount of maltodextrin is 0.9 kg, the usage amount of acryloyldimethyltaurine / VP copolymer is 0.18 kg, and the usage amount of water in phase A is 89.52 kg.

[0082] Example 8

[0083] A serum albumin-containing essence, which is different from Example 1 in that the mass ratio of maltodextrin to acryloyldimethyltaurine / VP copolymer is 1:2, that is, the usage amount of maltodextrin is 0.9 kg, the usage amount of acryloyldimethyltaurine / VP copolymer is 1.8 kg, and the usage amount of water in phase A is 87.9 kg.

[0084] Comparative Example

[0085] Comparative Example 1

[0086] A serum albumin-containing essence, which is different from Example 1 in that the sturgeon roe extract is replaced with green tea extract, the usage amount of sturgeon roe extract is 0 kg, and the usage amount of green tea extract is 1 kg.

[0087] Comparative Example 2

[0088] A serum albumin-containing essence, which is different from Example 1 in that ubiquinone is replaced with vitamin E, the usage amount of ubiquinone is 0 kg, and the usage amount of vitamin E is 0.1 kg.

[0089] Comparative Example 3

[0090] An essence containing serum albumin, which is different from that of Example 1 in that the serum albumin is replaced by disodium EDTA, the usage amount of serum albumin is 0 kg, and the usage amount of disodium EDTA is 0.16 kg.

[0091] Comparative Example 4

[0092] An essence containing serum albumin, which is different from that of Example 1 in that the usage amount of sturgeon roe extract is 0.2 kg, the usage amount of ubiquinone is 1 kg, and the usage amount of serum albumin is 0.06 kg.

[0093] Performance detection test

[0094] I. Human detection:

[0095] 1. Volunteer selection: Select 48 women aged between 30 and 35 years old with wrinkles on the face ranging from 10 to 70 mm in length. Divide the volunteers into 12 groups, with 4 in each group, and one group corresponds to one test sample.

[0096] Seven days before the test, only use clean water to wash the face, and spray toner after washing the face to keep the skin clean. Three days before the test, there are no obvious phenomena such as redness, dryness, and desquamation on the skin.

[0097] Exclusion criteria: Exclude patients with severe chronic wasting diseases; exclude patients with skin damage and inflammation; those with other severe diseases; and other special circumstances.

[0098] 2. Test samples: The essences of Examples 1 - 8 and Comparative Examples 1 - 4.

[0099] 3. Test items:

[0100] 1) Anti-wrinkle detection: Gather the volunteers in a room with the temperature controlled at 25 - 27 °C, and use the Antera3D multi-functional 3D skin imager to take pictures of the test areas around the eyes on the left and right eyes. This is the state before the test. Record the total number of wrinkles around the eyes on the left and right eyes, and focus on observing and marking the eye with deeper wrinkles around the eyes of the same volunteer, and record the length of the wrinkles on this eye.

[0101] The volunteers wash their faces with clean water and spray toner in the room, and apply 2 g of the corresponding test sample to the left and right eye areas respectively. After waiting quietly in the room for half an hour, take pictures with the skin imager again. This is the state after treatment. Record the total number of wrinkles around the left and right eyes again, and record the length of the wrinkles on the eye with deeper wrinkles after treatment.

[0102] When processing the data, first calculate the change rate of the total number of wrinkles and the change rate of the wrinkle length for each volunteer in the same group, remove the highest and lowest values in the same group, and then calculate the average value of the same group, which is recorded as the average change rate of the total number of wrinkles and the average change rate of the wrinkle length.

[0103] Total wrinkle number change rate: Wrinkle length change rate:

[0104] 2) Moisture retention detection: Use a skin moisture tester to test the volunteers in Test 1, and detect the eyes with relatively deep wrinkle lengths. Record the skin water content before the detection and 6 hours after applying the detection sample, calculate the water content change rate of each volunteer in the same group, remove the highest and lowest values in the same group, and calculate the average value of the same group, which is recorded as the average water content change rate.

[0105] Water content change rate:

[0106] 3) Subjective evaluation: Distribute questionnaires to the volunteers in Test 1, and record whether the detection sample is quickly absorbed and whether it makes the face sticky when the volunteers use it.

[0107] II. In vitro detection - Metal removal detection:

[0108] 1. Preparation: Add Pb(NO3)2 to 1 L of distilled water to prepare a 100 ppm metal aqueous solution for use.

[0109] 2. Drop 1.0 mL of the metal aqueous solution on the surface of a 5*5 cm suckling pig skin, and let it stand for 5 minutes. Then apply the detection samples (the essence solutions of Examples 1-8 and Comparative Examples 1-4) on the surface of the suckling pig skin and let it stand for 1 hour.

[0110] Wipe the suckling pig skin clean with a wet gauze, add it to 50 mL of methanol solution, extract it by ultrasonic oscillation for 60 minutes, and then mix it with another 50 mL of methanol solution. Take out the suckling pig skin to obtain the test solution.

[0111] Use a mass spectrometer to measure the test solution to obtain the remaining metal amount and record the removal rate.

[0112] Removal rate: The above test results are shown in Table 2.

[0113] The left eye image of one volunteer who used the essence solution of Example 6 taken by a skin imager is for reference Figure 1 .

[0114] The right eye image of the above volunteer taken by a skin imager is for reference Figure 2 .

[0115] Table 2

[0116]

[0117]

[0118] From the comparison of the detection data of Example 1 and Comparative Examples 1-3 in Table 2, it can be seen that the essence of Example 1 has a greater change in the total number of wrinkles and the length of wrinkles than those of Comparative Examples 1-3, and the change in water content in terms of moisturizing is also greater in Example 1 than in Comparative Examples 1-3. From this data comparison, it can be known that the wrinkles around the eyes of the volunteers who used the essence of Example 1 were effectively lifted and removed in a short time, and the moisture around the eyes was effectively supplemented, and the effect was more significant than that of Comparative Examples 1-3. In terms of the heavy metal removal rate, the essence of Example 1 also has a higher removal effect than those of Comparative Examples 1-3, indicating that the essence of Example 1 not only has good performance in wrinkle removal and moisturizing, but also can effectively reduce the heavy metals on the skin surface. The above comparison shows that under the specific combination of sturgeon roe extract, ubiquinone, and serum albumin, the formed moisturizing film has good effects on moisturizing the skin, lifting the skin, and relieving the stimulation of metal ions.

[0119] Combined with the comparison of the detection data of Comparative Example 4, it can be seen that the essence of Comparative Example 4 has a higher change rate in anti-wrinkle and moisturizing than those of Comparative Examples 1-3, but not as high as that of Example 1, and the heavy metal removal rate also shows the same trend. It shows that only by limiting the use of sturgeon roe extract, ubiquinone, and serum albumin, without limiting the combination of the three in a specific dosage ratio, the prepared essence cannot form an effective moisturizing film, and thus cannot have good moisturizing, lifting and other effects.

[0120] Compared with Comparative Example 4, in Example 4, the proportion of sturgeon roe extract, ubiquinone, and serum albumin was changed under specific dosages. The performance of Example 4 in all aspects was better than that of Comparative Example 4, but slightly worse than that of Example 1. This also shows that it is necessary to further limit the combination of sturgeon roe extract, ubiquinone, and serum albumin in specific proportions and dosages in order to quickly form a stable and effective special structure to act on the user's face.

[0121] From the comparison of the detection data of Example 1 and Example 5 in Table 2, it can be seen that the essence of Example 1 has a better improvement effect in terms of the average wrinkle length than that of Example 5, and the average water content change rate of Example 1 is also higher than that of Example 5. It shows that selecting a moisturizer with specific dosages, proportions, and types can have a better cooperation effect with the special structure formed by the combination of sturgeon roe extract, ubiquinone, and serum albumin.

[0122] From the comparison of the detection data of Example 1, 7 and Example 8 in Table 2, it can be seen that after changing the usage ratio of acryloyldimethyltaurate / VP copolymer and maltodextrin in Example 8, the prepared essence has a slight feeling of sticking to the face and is not as refreshing as that of Example 1; the performance in other aspects such as anti-wrinkle and moisturizing is also affected. It shows that limiting the combination of acryloyldimethyltaurate / VP copolymer and maltodextrin in a specific ratio is beneficial to further improve the effect of the essence.

[0123] This specific embodiment is only an interpretation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment that do not contribute creatively as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. An essence containing serum albumin, characterized in that, By mass percentage, it comprises the following components: Phase A: water, 1 - 10% humectant, 0 - 1% antioxidant, 0 - 2% thickener; Phase B: 0.5 - 3% sturgeon roe extract, 0.05 - 0.5% ubiquinone, 0 - 3% skin conditioner, 0.1 - 5% solvent, 0.1 - 0.5% serum albumin; Water makes up the balance to 100%; The skin conditioner is maltodextrin, and the thickener is ammonium acryloyldimethyltaurate / VP copolymer. The mass ratio of maltodextrin to ammonium acryloyldimethyltaurate / VP copolymer is 1:(0.2 - 0.4), based on the mass of maltodextrin.

2. The essence containing serum albumin according to claim 1, characterized in that: The mass ratio of the sturgeon roe extract, ubiquinone, and serum albumin is 1:(0.05 - 0.15):(0.1 - 0.2), based on the mass of the sturgeon roe extract.

3. The essence containing serum albumin according to claim 1, characterized in that: The humectant includes one or more of sodium hyaluronate, butylene glycol, allantoin, 1,2 - hexanediol, and glycerol.

4. The essence containing serum albumin according to claim 3, wherein: The humectant is sodium hyaluronate, butylene glycol, and allantoin. By mass percentage, sodium hyaluronate accounts for 0.1 - 0.5% of the total essence, butylene glycol accounts for 3 - 6% of the total essence, and allantoin accounts for 0.05 - 0.3% of the total essence.

5. A method for preparing a serum albumin-containing essence according to any one of claims 1-4, characterized in that, It includes the following steps: Mix various raw materials of Phase A evenly to obtain Phase A; Mix various raw materials of Phase A and Phase B until evenly mixed to obtain the finished product.

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