Screen for chromatography column and manufacturing process thereof

Abstract

The present application relates to the technical field of chromatography process, provide a kind of screen for chromatographic column and its manufacturing process, including filter piece, support and welding material, filter piece is provided with mesh;Form welding edge on the side of support, and the welding edge is surrounded into chromatographic hole;Welding edge is provided with welding protrusion;When welding protrusion is in initial state, welding protrusion is located at the first side of filter piece;When welding protrusion is in molten state, welding protrusion can be passed through the mesh of filter piece;When welding material is in initial state, welding material is located at the second side of filter piece;When welding material is in molten state, welding material can be passed through the mesh of filter piece.The screen for chromatographic column and its manufacturing process of the present application increase the area of chromatographic hole, improve the chromatography efficiency;Meanwhile, filter piece is welded on support by welding material between, so that the surface of screen is flat, while reducing the sanitary dead angle of support.

Description

Technical Field

[0001] This invention relates to the technical field of chromatography processes, and more particularly to a sieve for chromatography columns and its manufacturing process. Background Technology

[0002] Chromatography is the most widely used core purification method in the biopharmaceutical field. In conventional chromatography equipment, the chromatography column is the most crucial component. An axially compressed chromatography column typically includes a column body, column head, bottom sieve plate, and column feet. The chromatography medium is installed inside the column, located between the column head and the bottom sieve plate, to perform its liquid chromatography purification function.

[0003] The sieve of a chromatography column consists of annular supports and filter elements. The annular supports are typically made of polypropylene (PP), while the sieve material is usually polyamide (PA). Due to the high melting point of PA, the PA filter cloth and the PP annular supports are almost impossible to fuse effectively using ultrasonic welding or thermoforming welding.

[0004] Therefore, all chromatography column screens currently on the market use a "coating" process to achieve a fusion seal between the PP polypropylene ring support and the PA polyamide filter cloth.

[0005] This type of overmolding process, such as Figure 1 As shown, a fixing groove 140 is first opened on the inner side of the annular support 100'. Then, using a special overmolding clamp, the PA polyamide filter element is pressed into the fixing groove 140. Molten PP polypropylene is then injected into the outer periphery of the fixing groove 140 of the annular support 100' to wrap the PA polyamide filter element in a thermoplastic encapsulation manner.

[0006] The coating process is complex, requiring the creation of a fixing groove 140. Therefore, the cross-sectional width of the annular support 100' is large, resulting in a significant height difference between the portion of the filter cloth enclosed by the fixing groove 140 and the portion not enclosed. Consequently, the effective area of ​​the screen produced by the coating process is reduced, while the non-hygienic area and the dead volume area of ​​the material increase. Furthermore, due to its hot-injection operation, the coating process is prone to defects at high temperatures. Air bubbles are trapped during the hot glue injection process, affecting the appearance and curvature of the support after cooling and molding, resulting in uneven wrinkles in the filter cloth of the screen. Summary of the Invention

[0007] This invention provides a screen for chromatography columns and its manufacturing process, which solves the defect of uneven filter cloth wrinkles in the existing hot-coating process and achieves a smooth screen surface.

[0008] This invention provides a sieve for a chromatography column, comprising:

[0009] Filter element, wherein the filter element is provided with a mesh;

[0010] A support member has a welded edge formed on one side, the welded edge forming a diaphragm hole; a welded protrusion is provided on the welded edge;

[0011] The weld protrusion has an initial state and a molten state; when the weld protrusion is in the initial state, it is located on the first side of the filter element; when the weld protrusion is in the molten state, it can pass through the mesh of the filter element.

[0012] The welding material has an initial state and a molten state; when the welding material is in the initial state, it is located on the second side of the filter element; when the welding material is in the molten state, it can pass through the mesh of the filter element.

[0013] According to the present invention, a screen for a chromatography column is provided in which the cross-sectional area of ​​the welded protrusion gradually decreases from its root to its end.

[0014] According to the present invention, a screen for a chromatography column is provided in which the melting point of the welding material and the welding protrusion are both lower than the melting point of the filter element.

[0015] According to the present invention, a screen for a chromatography column is provided, wherein the welding material is the same as the welding protrusion.

[0016] According to the present invention, a screen for a chromatography column is provided, wherein the area of ​​the welding material is larger than the area of ​​the filter element, and the welding material can completely cover the filter element.

[0017] According to the present invention, a sieve for a chromatography column is provided, wherein the welding material is a mesh.

[0018] According to the present invention, a screen for a chromatography column is provided, wherein the welding material is provided with a tear.

[0019] The present invention also provides a manufacturing process for a screen, comprising the following steps:

[0020] Step 1: Place the filter element on the support, place the welding material on the filter element, and tighten the filter element;

[0021] Step 2: Melt the welding material and the welding protrusion. The molten welding material passes through the mesh of the filter element; the molten welding protrusion passes through the mesh of the filter element; the molten welding material and the molten welding protrusion fuse together, cool, and the filter element is fixed on the support.

[0022] The manufacturing process of a screen according to the present invention further includes step three:

[0023] Remove the excess welding material along the inside and outside of the weld edge.

[0024] According to a screen manufacturing process provided by the present invention, in step one, a tear is made in the middle of the welding material.

[0025] According to a screen manufacturing process provided by the present invention, in step two,

[0026] The welding material in a molten state fuses with the welding protrusion in a molten state to form a welding structure, which is used to connect the support and the filter. The welding structure includes a first welding layer, a second welding layer and welding ribs. The first welding layer covers the welding area, and the second welding layer connects the support and the filter. The welding ribs pass through the mesh and connect the first welding layer and the second welding layer.

[0027] According to a screen manufacturing process provided by the present invention, in step two, "melting the welding material and the welding protrusion" means melting the welding material and the welding protrusion using an ultrasonic welding machine.

[0028] According to a manufacturing process for a screen provided by the present invention, the welding material is a mesh.

[0029] According to a screen manufacturing process provided by the present invention, the area of ​​the welding material is not less than the area of ​​the cross-section of the root of the welding protrusion.

[0030] According to a screen manufacturing process provided by the present invention, the area of ​​the welding material is not less than the area of ​​the filter element.

[0031] According to a screen manufacturing process provided by the present invention, the cross-sectional area of ​​the welded protrusion gradually decreases from its root to its end.

[0032] The manufacturing process of a sieve according to the present invention further includes step four:

[0033] Use a hot-welding head to heat-melt and flatten the support component;

[0034] Trim the excess filter material along the outer edge of the support.

[0035] The present invention also provides a filter, comprising:

[0036] A support member, wherein a welded edge is formed on one side of the support member, the welded edge forming a diaphragm;

[0037] A filter element, which is welded to the support member; the filter element is provided with a mesh; the filter element includes a filtration area and a welding area, the filtration area corresponding to the chromatography pores, and the welding area corresponding to the welding edge;

[0038] A welded structure is provided for connecting the support member and the filter element; the welded structure includes a first welded layer, a second welded layer, and weld ribs, the first welded layer covers the welded area, the second welded layer connects the support member and the filter element; the weld ribs pass through the mesh and connect the first welded layer and the second welded layer.

[0039] According to a filter provided by the present invention, a welding material is further included, and the support member is provided with the welding protrusion; initially, the welding protrusion is located on a first side of the filter member; the welding material is located on a second side of the filter member; after welding, the welding protrusion and the welding material flow and mix in a molten state, and form the welded structure after cooling.

[0040] According to a filter provided by the present invention, the height of the first welded layer is 0-100 μm.

[0041] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

[0042] The screen used for the chromatography column includes a filter element, a support element, and welding material. The filter element has mesh openings. A welded edge is formed on one side of the support element, which surrounds the chromatography pores. Welded protrusions are provided on the welded edge. The welded protrusions have an initial state and a molten state. When the welded protrusions are in the initial state, they are located on the first side of the filter element. When the welded protrusions are in the molten state, they can pass through the mesh openings of the filter element. The welding material also has an initial state and a molten state. When the welding material is in the initial state, it is located on the second side of the filter element. When the welding material is in the molten state, it can pass through the mesh openings of the filter element.

[0043] The filter element has a mesh. When the welding material is molten, it can pass through the mesh. When the welding protrusion is molten, it can also pass through the mesh. Cooling then solidifies the fused welding material and protrusion, fixing the filter element to the surface of the support. This ensures a tight fit between the filter element and the support, resulting in a taut and smooth screen, completely eliminating the problem of wrinkles and unevenness in the filter cloth during the thermoplastic coating process. Compared to traditional rubber coating, the welding edge is narrower, forming chromatography pores and increasing their area, thus improving chromatography efficiency. Furthermore, the welding of the filter element to the support through the welding material ensures a smooth screen surface and reduces unsanitary corners on the support.

[0044] The present invention also provides a manufacturing process for a screen, wherein the filter element and the support element are tightly bonded by welding materials and welding protrusions, resulting in a screen with high tension and a smooth surface, completely eliminating the problem of uneven filter cloth wrinkles in the thermoplastic coating process. Attached Figure Description

[0045] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0046] Figure 1 This is a schematic diagram of the overmolding process in existing technology;

[0047] Figure 2 This is a schematic diagram of the structure of the sieve for the chromatography column provided in the first aspect embodiment of the present invention in its initial state;

[0048] Figure 3 This is a three-dimensional structural schematic diagram of a support member for a sieve used in a chromatography column provided in the first aspect embodiment of the present invention;

[0049] Figure 4 This is a schematic diagram of step one of the manufacturing process of the screen provided in the second aspect embodiment of the present invention;

[0050] Figure 5 This is another schematic diagram of step one of the manufacturing process of the screen provided in the second aspect embodiment of the present invention;

[0051] Figure 6 This is a schematic diagram of step two of the manufacturing process of the screen provided in the second aspect embodiment of the present invention;

[0052] Figure 7 This is a schematic diagram of step three of the manufacturing process of the screen provided in the second aspect embodiment of the present invention;

[0053] Figure 8 This is another processing diagram illustrating step two of the screen manufacturing process provided in the second aspect embodiment of the present invention;

[0054] Figure 9 This is a software analysis diagram of the tensile test of the manufacturing process of the screen provided in this embodiment of the invention;

[0055] Figure 10 This is a data trend graph of the tensile test of the manufacturing process of the screen provided in the embodiment of the present invention;

[0056] Figure 11This is a three-dimensional structural diagram of a filter provided in the third aspect embodiment of the present invention.

[0057] Figure label:

[0058] 100 (100'), support; 110, weld edge; 120, chromatography pore; 130, weld protrusion; 140, fixing groove;

[0059] 200. Filter element; 210. Filtration zone; 220. Welding zone;

[0060] 300. Welding materials;

[0061] 400, Welded structure; 410, First welded layer; 420, Second welded layer; 430, Welded rib. Detailed Implementation

[0062] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0063] This embodiment provides a sieve for a chromatography column, such as... Figures 2 to 3 As shown, the filter includes a filter element 200, a support member 100, and welding material 300. The filter element 200 has a mesh. A welding edge 110 is formed on one side of the support member 100, which surrounds a chromatography pore 120. Welding protrusions 130 are provided on the welding edge 110. The welding protrusions 130 have an initial state and a molten state. When the welding protrusions 130 are in the initial state, they are located on the first side of the filter element 200. When the welding protrusions 130 are in the molten state, they can pass through the mesh of the filter element 200. The welding material 300 has an initial state and a molten state. When the welding material 300 is in the initial state, it is located on the second side of the filter element 200. When the welding material 300 is in the molten state, it can pass through the mesh of the filter element 200.

[0064] The filter element 200 has a mesh. When the welding material 300 is in a molten state, it can pass through the mesh of the filter element 200. When the welding protrusion 130 is in a molten state, it can also pass through the mesh of the filter element 200. After cooling, the fused welding material 300 and the welding protrusion 130 are solidified, thus fixing the filter element 200 to the surface of the support 100. This ensures that the filter element 200 and the support 100 are tightly fitted, resulting in a screen with high tension and a smooth surface, completely eliminating the problem of uneven filter cloth wrinkles in the thermoplastic coating process. At the same time, compared with the traditional rubber coating process, the welding edge 110 is narrower, and the welding edge 110 surrounds the chromatography pores 120, increasing the area of ​​the chromatography pores 120 and improving the chromatography efficiency. Meanwhile, the filter element 200 is welded to the support 100 through the welding material 300, making the surface of the screen smooth and reducing the sanitary dead corners of the support 100.

[0065] like Figure 3 As shown, a welding edge 110 is formed on one side of the support 100, and the welding edge 110 surrounds the chromatography hole 120. Generally, the support 100 is annular and the chromatography hole 120 is circular. After the filter element 200 is welded onto the support 100, the liquid completes chromatography through the chromatography hole.

[0066] Preferred, such as Figure 2 As shown, the cross-sectional area of ​​the welding protrusion 130 gradually decreases from its root to its end, so that the welding protrusion 130 in the initial state forms a tip on the first side of the filter element 200, which is beneficial for receiving energy and accelerating the melting of the welding protrusion 130; of course, in other embodiments, the welding protrusion 130 may also be of other shapes.

[0067] Generally, filter element 200 is a filter cloth in the prior art; filter cloth is a filter medium woven from natural or synthetic fibers. Commonly used materials include cotton, linen, wool, silk, asbestos fiber, glass fiber, and certain synthetic fibers; for example, cotton canvas, twill fabric, and woolen fabric. In order to weld the filter element 200 to the support 100 using welding material 300 and welding protrusion 130, the melting points of both welding material 300 and welding protrusion 130 are lower than the melting point of the filter element 200, so as to prevent the filter element 200 from melting during the welding process. In order to enable the welding material 300 and welding protrusion 130 to better fuse and fix the filter element 200, the welding material 300 and welding protrusion 130 are made of the same material. Since the same material has the same melting point, the welding material 300 and welding protrusion 130 can melt simultaneously when heated to the same temperature, that is, at the same time, the welding material 300 and welding protrusion 130 simultaneously pass through the mesh of the filter element 200 so that the two can fuse together. Meanwhile, the same material has the same solidification temperature, which is beneficial for molding after melting and makes it easier to control the welding temperature. In this embodiment, the material of the filter element 200 is PA polyamide, and the materials of the welding material 300 and the welding protrusion 130 are PP polypropylene. Since PA polyamide is a nylon material with a very high melting point, it is almost impossible for it to be effectively fused with the PP polypropylene of the support 100 by ultrasonic welding or hot melt welding. Therefore, the PA polyamide filter element 200 and the PP polypropylene support 100 are tightly combined by the PP polypropylene welding material 300 and the welding protrusion 130, ensuring the flatness of the filter element 200 and the strong tension of the screen, thus completely eliminating the problem of uneven filter cloth wrinkles in the thermoplastic process.

[0068] The area of ​​the welding material 300 is larger than the area of ​​the filter element 200, and the welding material 300 can completely cover the filter element 200 to ensure that the welding material 300 can penetrate into the filter element 200 to complete the fixation of the filter element 200.

[0069] Preferably, the welding material 300 is mesh-like, which facilitates the melting of the welding material 300 and makes it easy to remove excess material after welding.

[0070] Preferably, the welding material 300 is provided with a tear opening to facilitate the removal of excess material after welding. Specifically, the tear opening is a cross-shaped opening, which is easy to process and facilitates the removal of excess material from the welding material 300.

[0071] The present invention also provides a manufacturing process for a screen, comprising the following steps:

[0072] Step 1: As Figures 4 to 5As shown, the filter element 200 is placed on the support member 100, the welding material 300 is placed on the filter element 200, and the filter element 200 is tightened.

[0073] Step Two: As Figure 6 As shown, the welding material 300 and the welding protrusion 130 are melted. The welding material 300 in the molten state passes through the mesh of the filter element 200; the welding protrusion 130 in the molten state passes through the mesh of the filter element 200; the welding material 300 in the molten state and the welding protrusion 130 in the molten state fuse together, cool, and the filter element 200 is fixed on the support member 100.

[0074] In step one, the support 100 is a PP polypropylene support ring, and the welding material 300 and welding protrusion 130 are both made of PP polypropylene. PP polypropylene is an organic material with a low melting point to ensure optimal thermal fusion. The filter cloth forming the welding material 300 has a weaving density of 20 mesh to 800 mesh, and the diameter of the fibers weaving the welding material 300 should not be too thick, preferably around 80 to 300 μm, to facilitate switching the welding material 300 to the molten state in step two. μm refers to nanometers. The filter element 200 is a PA polyamide filter cloth. The filter element 200 is laid flat on the support 100, stretched, and then welded. This helps the filter element 200 maintain its flatness, resulting in a screen with strong tension and a smooth surface, completely eliminating the problem of uneven filter cloth wrinkles in the thermoplastic coating process. The area of ​​the welding material 300 is not less than the area of ​​the filter element 200, so that the welding material 300 can cover the filter element 200, thereby welding the welding area 220 of the filter element 200 to the welding edge 110.

[0075] In this embodiment of the invention, the filter element 200 is directly laid on the support element 100 and then welded together with welding material 300 and welding protrusion 130. Compared with the traditional coating process, there is no need to set the fixing groove 140, which can reduce the overall volume of the support element 100, avoid non-hygienic areas and dead volume areas of materials, and solve the problem of air bubbles being sealed in the hot glue injection process during the coating process, which affects the appearance and warping strength of the support element 100 after cooling and molding.

[0076] like Figures 2 to 3 As shown, the cross-sectional area of ​​the welding protrusion 130 gradually decreases from its root to its end, so that the welding protrusion 130 in the initial state forms a tip on the first side of the filter element 200, which is beneficial for receiving energy and accelerating the melting of the welding protrusion 130; of course, in other embodiments, the welding protrusion 130 may also be of other shapes.

[0077] The present invention provides a screen manufacturing process in which the filter element 200 and the support element 100 are tightly combined by welding material 300 and welding protrusion 130; the resulting screen has strong tension and a smooth surface, completely eliminating the problem of uneven filter cloth wrinkles in the hot-coating process.

[0078] In step two, "melting the welding material 300 and the welding protrusion 130" refers to melting the welding material 300 and the welding protrusion 130 using an ultrasonic welding machine. In existing hot-coating processes, if the shrinkage of the plastic cannot be precisely controlled, it will cause wrinkles and unevenness on the support 100 of the filter element 200. However, ultrasonic welding is an instantaneous heat transfer process, and the plastic support 100 as a whole maintains its room temperature during the process, with almost no thermal deformation, resulting in a highly flat screen. Of course, in other embodiments, "melting the welding material 300 and the welding protrusion 130" can also be achieved using hot-melt welding.

[0079] The ultrasonic welding machine includes a base with a mounting groove for accommodating the support member 100. When melting the welding material 300 using the ultrasonic welding machine, the ultrasonic welding machine is adjusted to appropriate ultrasonic welding parameters (e.g., output power 1000W, welding time 5s) before welding.

[0080] Preferably, the embodiment of the present invention further includes step three: as follows Figure 7 As shown, the excess material of the welding material 300 is torn off along the inner and outer sides of the welding edge 110 to facilitate chromatography of the filter element 200.

[0081] In step one, before "placing the filter element 200 on the support 100 and placing the welding material 300 on the filter element 200", a tear is made in the middle of the welding material 300 to facilitate the removal of excess material after welding. Specifically, the tear is a cross-shaped opening, which is easy to process and facilitates the removal of excess material from the welding material 300. Specifically, the welding material 300 is mesh-like, which facilitates the melting of the welding material 300 and also makes it easy to remove excess material after welding.

[0082] Preferably, in step two, such as Figure 8As shown, the welding material 300 in a molten state and the welding protrusion 13 in a molten state fuse to form a welded structure 400, which is used to connect the support member 100 and the filter element 200. The welded structure 400 includes a first weld layer 410, a second weld layer 420, and a welding rib 430. The first weld layer 410 covers the welding area 220, and the second weld layer 420 connects the support member 100 and the filter element 200. The welding rib 430 passes through the mesh and connects the first weld layer 410 and the second weld layer 420. The welded structure 400 is formed by welding. The filter element 200 can be tightly fixed to the support 100, making it difficult to fall off; and the molten welding material 300 passes through the mesh of the filter element 200, and the welding material 300 forms a first welding layer 410 on the surface of the filter element 200. The first welding layer 410 is extremely thin, making the surface of the finished screen smooth and reducing the sanitary dead corners of the support 100; the second welding layer 420 connects the support 100 and the filter element 200, increasing the stability of the connection between the filter element 200 and the support 100; the welding rib 430 passes through the mesh and connects the first welding layer 410 and the second welding layer 420, playing a role in consolidating the connection.

[0083] Preferably, the area of ​​the welding material 300 is not less than the area of ​​the filter element 200, so that the welding material 300 can cover the filter element 200, thereby welding the welding area 220 of the filter element 200 to the welding edge 110. It can be understood that in step one, "placing the welding material 300 on the filter element 200", the welding material 300 is completely covered on the filter element 200, and the welding material 300 is hot-melted. The welding material 300 in the molten state can pass through the mesh of the filter element 200, which is convenient for welding.

[0084] In other embodiments, the area of ​​the welding material 300 is not less than the cross-sectional area of ​​the root of the welding protrusion 130. When melting, the welding material 300 in the molten state and the welding protrusion 130 in the molten state respectively penetrate from one side of the filter element 200 to the other side and fuse with each other, thereby achieving the effect of welding the filter element 200 to the support 100.

[0085] The manufacturing process of a sieve according to the present invention further includes step four:

[0086] The support 100 is heat-melted and flattened using a hot welding head; the excess filter element 200 on the outer edge of the support 100 is trimmed; through heat-melting and trimming, a complete screen is obtained to ensure the flatness of the screen surface.

[0087] The second aspect of the present invention provides a screen manufacturing process in which the filter element 200 and the support element 100 are tightly combined by welding material 300 and welding protrusion 130, resulting in a screen with high tension and a smooth surface, completely eliminating the problem of uneven filter cloth wrinkles in the thermoplastic coating process.

[0088] This embodiment of the invention also includes step four: using a hot welding head to heat-melt and flatten the support member 100; trimming the excess filter element 200 along the outer edge of the support member 100; through heat-melting and flattening and trimming, such as Figure 8 As shown, a complete sieve is obtained to ensure the flatness of the sieve surface.

[0089] The excess filter element 200 along the outer edge of the support member 100 can be trimmed using one of the following methods:

[0090] (1) Use scissors with heating function to heat trim excess fiber filaments.

[0091] (2) A roller with heating function is used to roll the welding area 220220 once or several times under pressure, thereby squeezing and hot melting the excess fiber burrs and smoothing them.

[0092] (3) Use ordinary scissors or paper cutter to manually trim excess fibers and filter cloth. Use a punching tool to punch and cut off excess filter cloth.

[0093] In this embodiment of the invention, a welding material 300 made of PP polypropylene or PE polyethylene and a welding protrusion 130 are used as auxiliary melting materials. During the ultrasonic welding process of pressure and high-frequency heating, the welding material 300 in a molten state passes through the mesh of the PA polyamide filter element 200 and fuses with the support 100, forming a "fixing rib" that penetrates the filter element 200 at the microscopic level. This achieves the fusion of the PA polyamide filter element 200 and the PP polypropylene support 100 through ultrasonic welding.

[0094] Compared to traditional overmolding processes, ultrasonic welding offers the following advantages:

[0095] (1) Short manufacturing time and low cost: Ultrasonic welding only takes a few seconds, while hot-rolling process takes several minutes; ultrasonic welding only requires a welding base, while hot-rolling process requires mold opening, injection molding, and cooling, and the cost is not comparable.

[0096] (2) A screen with an extremely narrow frame and minimal dead volume can be obtained: In this embodiment of the invention, the welding is directly applied between the PA polyamide filter element 200 and the support element 100, achieving a tight fusion between them. Compared with the traditional overmolding process, there is no step in the transition between the filter cloth and the support ring, and the width of the welding surface can be as narrow as less than 1 mm, making it possible to achieve the smallest possible dead volume of the component ring.

[0097] (3) The obtained screen surface is flat: Ultrasonic welding does not have the problem of plastic ring cooling and shrinkage faced by the hot-coating process. Therefore, the deformation of the screen after welding is small and the flatness is high.

[0098] Based on the screen manufacturing process provided in this embodiment of the invention, ultrasonic welding was performed on 10μm PA polyamide filter elements 200200 using 40, 60, and 80 mesh welding material 300, respectively. Tensile tests were conducted on the weld tightness between the PA polyamide and the support ring under welding conditions with different output power. The summarized data are as follows:

[0099] Screen mesh count (mesh) Ultrasonic output power % Welding strength score 40 60％ 4 40 60％ 5 60 60％ 6 60 60％ 6 80 60％ 8 80 60％ 8 40 90％ 8 40 90％ 10 60 90％ 9 60 90％ 8 80 90％ 10 80 90％ 9

[0100] The welding strength scoring criteria are as follows: 0-3 points for visible weak weld areas (whitening); 4-6 points for filter element 200200 being able to be torn off part of support element 100100 with slight force; 7-10 points for PA polyamide filter cloth being unable to be torn off with strong force.

[0101] like Figure 9 As shown in the analysis software, the welding method used in this invention, the mesh size of the membrane, and the output power of the ultrasonic welding all affect the welding strength. Specifically, a higher mesh size results in higher weld strength; higher ultrasonic power output also results in higher strength. There is no interaction between the mesh size of the sieve and the ultrasonic intensity.

[0102] like Figure 10 Trend analysis: The Y-axis represents welding strength; the X-axis represents the mesh size of the PP polypropylene filter; the trend of welding strength at 60% ultrasonic output power and 90% ultrasonic output power are shown in the figure.

[0103] The manufacturing process of the screen provided in this embodiment of the invention, under the condition of constant ultrasonic output power, results in stronger welding strength when the welding material 300 with a larger mesh size is fused with the support ring; however, increased strength is not the only basis for process selection and operation. Considering that the welding material 300 will be torn off later, under the above process conditions, the thickness of the fiber filaments used in the PP polypropylene screen determines, to a certain extent, the ease with which it is torn off the surface of the PA polyamide filter cloth after welding; preferably, this embodiment of the invention uses welding material 300 with a fiber filament diameter of about 80 to 300 μm.

[0104] A third aspect of the present invention also provides a filter, such as Figure 11 As shown, it includes:

[0105] A support member 100 has a welded edge 110 formed on one side, and the welded edge 110 surrounds a diaphragm pore 120.

[0106] The filter element 200 is welded to the support member 100; the filter element 200 is provided with a mesh; the filter element 200 includes a filtration area 210 and a welding area 220, the filtration area 210 corresponds to the chromatography pore 120, and the welding area 220 corresponds to the welding edge 110;

[0107] A welding structure 400 is provided to connect the support member 100 and the filter element 200. The welding structure 400 includes a first welding layer 410, a second welding layer 420, and welding ribs 430. The first welding layer 410 covers the welding area 220, and the second welding layer 420 connects the support member 100 and the filter element 200. The welding ribs 430 pass through the mesh and connect the first welding layer 410 and the second welding layer 420. The welding structure 400, formed by welding, can tightly fix the filter element 200 to the support member 100. The welded material 300, after melting, penetrates the mesh of the filter element 200, and forms a first weld layer 410 on the surface of the filter element 200. The first weld layer 410 is extremely thin, making the surface of the finished screen smooth and reducing the sanitary dead corners of the support element 100. The second weld layer 420 connects the support element 100 and the filter element 200, increasing the stability of the connection between the filter element 200 and the support element 100. The weld rib 430 passes through the mesh and connects the first weld layer 410 and the second weld layer 420, playing a role in consolidating the connection.

[0108] Preferred, such as Figure 8 As shown, it also includes welding material 300, and the support member 100 is provided with welding protrusion 130; initially, the welding protrusion 130 is located on the first side of the filter element 200; the welding material 300 is located on the second side of the filter element 200. When melting, the welding material 300 in the molten state and the welding protrusion 130 in the molten state penetrate from one side of the filter element 200 to the other side and then fuse with each other; after welding, the welding protrusion 130 and the welding material 300 flow and mix in the molten state, and after cooling, the welded structure 400 is formed, thereby achieving the effect of welding the filter element 200 to the support member 100.

[0109] The height of the first welding layer 410 is 0-100μm, which makes the surface of the filter flat and reduces dead corners for hygiene.

[0110] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A sieve for a chromatography column, characterized in that, include: A filter element (200) is provided with a mesh, and the filter element (200) includes a filtration area (210) and a welding area (220); A support member (100) has a welded edge (110) formed on one side, the welded edge (110) forming a diaphragm hole (120); a welded protrusion (130) is provided on the welded edge (110); The welding protrusion (130) has an initial state and a molten state; when the welding protrusion (130) is in the initial state, the welding protrusion (130) is located on the first side of the filter element (200); when the welding protrusion (130) is in the molten state, the welding protrusion (130) can be passed through the mesh of the filter element (200); Welding material (300), the welding material is mesh-like, the welding material (300) has an initial state and a molten state; when the welding material (300) is in the initial state, the welding material (300) is located on the second side of the filter element (200); when the welding material (300) is in the molten state, the welding material (300) can pass through the mesh of the filter element (200), and by cooling, the fused welding material (300) and the welding protrusion (130) are in a solidified state to form a welded structure (400), thereby realizing the welding of the filter element (200). The filter element (200) is fixed to the surface of the support member (100) so that it fits tightly against the support member (100). The welded structure (400) includes a first welded layer (410), a second welded layer (420), and a weld rib (430). The first welded layer (410) covers the welded area (220), and the second welded layer (420) connects the support member (100) and the filter element (200). The weld rib (430) passes through the mesh and connects the first welded layer (410) and the second welded layer (420).

2. The sieve for a chromatography column according to claim 1, characterized in that, The cross-sectional area of ​​the weld protrusion (130) gradually decreases from its root to its end.

3. The sieve for a chromatography column according to claim 1, characterized in that, The melting points of both the welding material (300) and the welding protrusion (130) are lower than the melting point of the filter element (200).

4. The sieve for a chromatography column according to claim 3, characterized in that, The welding material (300) and the welding protrusion (130) are made of the same material.

5. The sieve for a chromatography column according to any one of claims 1 to 4, characterized in that, The area of ​​the welding material (300) is larger than the area of ​​the filter element (200), and the welding material (300) can completely cover the filter element (200).

6. The sieve for a chromatography column according to claim 5, characterized in that, The welding material is provided with a tear.

7. A manufacturing process for a sieve, based on the sieve for a chromatography column according to any one of claims 1 to 6, characterized in that, Includes the following steps: Step 1: Place the filter element (200) on the support (100), place the welding material (300) on the filter element (200), and tighten the filter element (200); Step 2: Melt the welding material (300) and the welding protrusion (130). The molten welding material (300) passes through the mesh of the filter element (200); the molten welding protrusion (130) passes through the mesh of the filter element (200); the molten welding material (300) and the molten welding protrusion (130) fuse together, cool, and the filter element (200) is fixed on the support member (100). In step two, The welding material (300) in a molten state and the welding protrusion (130) in a molten state fuse to form a welding structure (400), which is used to connect the support member (100) and the filter element (200). The welding structure (400) includes a first welding layer (410), a second welding layer (420) and a welding rib (430). The first welding layer (410) covers the welding area (220), and the second welding layer (420) is connected between the support member (100) and the filter element (200). The welding rib (430) passes through the mesh and connects the first welding layer (410) and the second welding layer (420).

8. The manufacturing process of the screen according to claim 7, characterized in that, It also includes step three: Remove the excess material of the welding material (300) along the inside and outside of the welding edge (110).

9. The manufacturing process of the screen according to claim 8, characterized in that, In step one, a tear is made in the middle of the welding material (300).

10. The manufacturing process of the screen according to any one of claims 7 to 9, characterized in that, In step two, "melting the welding material (300) and the welding protrusion (130)" means melting the welding material (300) and the welding protrusion (130) using an ultrasonic welding machine.

11. The manufacturing process of the screen according to any one of claims 7 to 9, characterized in that, The welding material (300) is mesh-like.

12. The manufacturing process of the screen according to any one of claims 7 to 9, characterized in that, The area of ​​the welding material (300) is not less than the area of ​​the cross-section of the root of the welding protrusion (130).

13. The manufacturing process of the screen according to any one of claims 7 to 9, characterized in that, The area of ​​the welding material (300) is not less than the area of ​​the filter element (200).

14. The manufacturing process of the screen according to any one of claims 7 to 9, characterized in that, The cross-sectional area of ​​the weld protrusion (130) gradually decreases from its root to its end.

15. The manufacturing process of the screen according to claim 8, characterized in that, It also includes step four: The support (100) is heat-melted and flattened using a hot welding head; Trim the excess filter element (200) along the outer edge of the support (100).

16. A filter, based on the manufacturing process of the screen according to any one of claims 7 to 15, characterized in that, include: A support member (100) has a welded edge (110) formed on one side, the welded edge (110) forming a diaphragm hole (120); A filter element (200) is welded to the support member (100); the filter element (200) is provided with a mesh; the filter element (200) includes a filtration area (210) and a welding area (220), the filtration area (210) corresponds to the chromatography pores (120), and the welding area (220) corresponds to the welding edge (110); A welding structure (400) is provided for connecting the support member (100) and the filter element (200). The welding structure (400) includes a first welding layer (410), a second welding layer (420), and a welding rib (430). The first welding layer (410) covers the welding area (220), and the second welding layer (420) is connected between the support member (100) and the filter element (200). The welding rib (430) passes through the mesh and connects the first welding layer (410) and the second welding layer (420).

17. The filter according to claim 16, characterized in that, It also includes welding material (300), and the support member (100) is provided with the welding protrusion (130); initially, the welding protrusion (130) is located on the first side of the filter element (200); the welding material (300) is located on the second side of the filter element (200); after welding, the welding protrusion (130) and the welding material (300) flow and mix in a molten state, and after cooling, the welded structure (400) is formed.

18. The filter according to claim 16, characterized in that, The height of the first weld layer (410) is 0-100μm.

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