Guiding member, bottling device and apparatus for preparing frozen pellets

Abstract

This application discloses a guide component, a bottling device, and an apparatus for preparing frozen microspheres. The guide component is used for bottling frozen microspheres and includes a body, a neck connecting the body, and a guide channel. The guide channel extends through the neck to form an outlet for discharging the frozen microspheres. The body includes a mounting plate away from the outlet, with an inlet on the mounting plate. The centerline of the guide channel is a straight line, and the inner wall of the guide channel includes a guiding inner wall section that slopes towards the outlet and towards the centerline of the guide channel. The body has a connecting hole that connects to the guide channel, and the shape formed by any region of the connecting hole is not equal to or includes a cross-section passing through the center of the frozen microsphere. This application simultaneously realizes the freezing preparation and collection and bottling of frozen microspheres, avoiding moisture absorption during the bottling process.

Description

Technical Field

[0001] This application relates to the technical field of frozen microsphere preparation equipment, specifically to a guide component, a bottling device, and equipment for preparing frozen microspheres. Background Technology

[0002] Because biological agents require high activity during use, existing technologies often employ cold chain transportation and storage to maintain their viability. Each dose of biological agent is prepared into frozen pellets, which are then processed using freeze-drying equipment to form freeze-dried pellets. During long-term research and development, the inventors of this application discovered that in the production process of frozen pellets, the freezing preparation and collection of the frozen pellets are completed separately, resulting in frozen pellets that are prone to deliquescence and have a fragile, easily broken structure. Summary of the Invention

[0003] This application provides a guiding component that simultaneously realizes the freezing preparation of frozen pellets and the collection and bottling of frozen pellets, avoiding moisture absorption during the bottling process.

[0004] To solve the above-mentioned technical problems, one technical solution adopted in this application is: a guide member for bottling frozen microspheres, the guide member comprising a body, a neck connecting the body, and a guide channel; the guide channel passing through the neck to form an outlet for discharging the frozen microspheres; the body comprising a mounting plate away from the outlet, the mounting plate having an inlet; the centerline of the guide channel being a straight line, and the inner wall of the guide channel comprising a guiding inner wall segment inclined towards the outlet and towards the centerline of the guide channel; the body comprising a connecting hole communicating with the guide channel, wherein the shape formed by any region of the connecting hole is not equal to or includes a cross section passing through the center of the frozen microsphere.

[0005] According to one embodiment of this application, the guide channel includes a first columnar wall segment connected to the mounting plate; the guide inner wall segment is located between the first columnar wall segment and the neck, and the connecting hole is disposed in the body portion located between the neck and the guide inner wall segment.

[0006] According to one embodiment of this application, the depth of the first columnar wall segment is 1 / 2 to 2 / 3 of the depth of the guide channel.

[0007] According to one embodiment of this application, there are several connecting holes, and their proportion per unit area is 75% to 85%.

[0008] According to one embodiment of this application, there are a plurality of connecting holes, each of which is rectangular. The connecting holes are evenly arranged in a plurality of columns, and each column includes a plurality of rows of evenly arranged connecting holes. The gap between each adjacent column is equal.

[0009] According to one embodiment of this application, the guide channel includes a plurality of guide inner wall segments arranged along the direction from the inlet to the outlet, and the slope of the guide inner wall segments increases sequentially along the direction from the inlet to the outlet. The connecting hole is disposed in the body portion located between the neck and any one of the guide inner wall segments.

[0010] According to one embodiment of this application, the guide channel further includes at least one second columnar wall segment and at least one conical wall segment, the second columnar wall segment and the conical wall segment being alternately arranged; the inner guide wall segment corresponds to the conical wall segment; along the direction from the inlet to the outlet, the slope of the conical wall segment increases sequentially, and the size of the guide channel decreases; one of the conical wall segments is connected to the first columnar wall segment; the other conical wall segment is connected to the neck; the connecting hole is provided in any one of the second columnar wall segments.

[0011] According to one embodiment of this application, the body includes at least two cylindrical segments and at least two conical segments, wherein one of the cylindrical segments is connected to the mounting plate; the cylindrical segments and the conical segments are arranged alternately at intervals; the hollow spaces of the cylindrical segments and the conical segments together form the guide channel, wherein each guide inner wall segment corresponds to the inner wall of the conical segment, and the first cylindrical wall segment is the inner wall of the cylindrical segment connected to the mounting plate; along the direction from the inlet to the outlet, the size of the cylindrical segments decreases, and the slope of the guide inner wall segments increases sequentially.

[0012] According to one embodiment of this application, at least one isolation plate is also fixed on the mounting plate, each isolation plate is located within the guide channel, and the isolation plate divides the guide channel into several sub-channels; the length of each isolation plate is less than the depth of the guide channel; the inlet includes multiple inlets, and each inlet is connected to a corresponding sub-channel.

[0013] According to one embodiment of this application, the inner wall of the guide channel is further provided with a coating layer.

[0014] According to one embodiment of this application, the coating layer is a Teflon layer.

[0015] Another technical solution adopted in this application is: a bottling device for collecting frozen pellets, the bottling device including a sealing bottle, the sealing bottle including a bottle mouth, the bottling device further including the guide member as described above; the neck is installed on the bottle mouth, and the neck and the bottle mouth are in clearance fit.

[0016] According to one embodiment of this application, the gap between the bottle mouth and the neck is smaller than the diameter of the frozen pellet.

[0017] Another technical solution adopted in this application is: a preparation device for frozen microspheres, including the bottling device described above.

[0018] The beneficial effects of this application are as follows: A guiding component comprising a body, a neck, and a guiding channel is provided. A reagent liquid is introduced into the guiding channel via an inlet on a mounting plate. Then, a guide inner wall section inclined towards the outlet and the centerline of the guiding channel guides the frozen microspheres formed by the reagent liquid, causing the frozen microspheres to fall towards the outlet. Simultaneously, coolant is delivered to the guiding channel through a connecting hole. Furthermore, the cross-section formed within any region of the connecting hole has a shape that is not equal to or includes the center of the frozen microsphere, preventing leakage of the processed frozen microspheres from the connecting hole and ensuring that the processed frozen microspheres can leak out from the outlet, thus ensuring that the frozen microspheres can be bottled immediately from the outlet. In this way, after the frozen microspheres are prepared, the guiding component can collect and bottle the frozen microspheres, preventing them from becoming damp during the bottling process. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort, wherein:

[0020] Figure 1 This is a schematic diagram of the structure of a guiding component in an embodiment of this application;

[0021] Figure 2 yes Figure 1 A schematic diagram of a cross-sectional structure along section line AA;

[0022] Explanation of main structure and symbols:

[0023] 100. Guiding component; 110. Body; 111. Mounting plate; 112. Inlet; 113. Columnar cylindrical section; 114. Conical cylindrical section; 120. Neck; 130. Guiding channel; 131. Guiding inner wall section; 132. First columnar wall section; 133. Second columnar wall section; 134. Sub-channel; 140. Outlet; 150. Connecting hole; 160. Separator plate; 200. Bottling device; 210. Sealing bottle; 211. Bottle mouth. Detailed Implementation

[0024] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0025] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0026] Please see Figures 1 to 2 This application provides a guide component for bottling frozen microspheres (not shown in the figure). The guide component 100 includes a body 110, a neck 120 connecting the body 110, and a guide channel 130; the guide channel 130 passes through the neck 120 to form an outlet 140 for discharging frozen microspheres; the body 110 includes a mounting plate 111 away from the outlet 140, and the mounting plate 111 has an inlet 112; the centerline of the guide channel 130 is a straight line, and the inner wall of the guide channel 130 includes a guiding inner wall segment 131 that is inclined towards the outlet 140 and towards the centerline of the guide channel 130; the body 110 has a connecting hole 150 communicating with the guide channel 130, and the shape formed by any region of the connecting hole 150 is not equal to or includes a cross section passing through the center of the frozen microsphere.

[0027] Furthermore, the guide channel 130 is a channel inside the body 110; the shape formed by any range of the connecting hole 150 is not equal to or includes the cross section passing through the center of the frozen ball, so that the frozen ball will not leak out from the connecting hole 150, and the connecting hole 150 is connected to the Dewar flask, so that the coolant in the Dewar flask enters into the guide channel 130.

[0028] In actual operation, the connecting hole 150 is used to fill the guide channel 130 with a coolant such as liquid nitrogen. The reagent solution introduced through the inlet 112 enters the guide channel 130, thereby cooling it with the coolant such as liquid nitrogen in the guide channel 130 and forming frozen spheres. Then, the frozen spheres move along the guide channel 130 under the action of gravity, and are guided smoothly towards the outlet 140 by the guiding action of the inner wall section 131. A sealing bottle 210 is placed at the outlet 140, so that the frozen spheres leaking out of the outlet 140 are guided into the sealing bottle 210.

[0029] This application utilizes the inlet 112 on the mounting plate 111 to guide the reagent liquid into the guide channel 130. Then, the guide inner wall section 131, which is inclined towards the outlet 140 and the center line of the guide channel 130, guides the frozen pellets. Furthermore, by changing the height position of the frozen pellets falling onto the guide inner wall section 131, the frozen pellets formed by the simultaneously introduced reagent liquid are prevented from concentrating at the outlet 140, thus avoiding the accumulation of frozen pellets at the outlet 140. At the same time, coolant is delivered to the guide channel 130 through the connecting hole 150. The cross-section formed by any area of ​​the connecting hole 150 is not equal to or includes the center of the frozen pellet, preventing the frozen pellets from leaking out of the connecting hole 150 and ensuring that the frozen pellets can leak out of the outlet 140. Thus, after the frozen pellets are prepared, the guide member 100 can collect and bottle the frozen pellets, preventing them from getting damp during the bottling process and also preventing the frozen pellets from accumulating at the outlet 140.

[0030] Please see Figures 1 to 2 According to one embodiment of this application, the guide channel 130 includes a first columnar wall section 132 connected to the mounting plate 111; the guide inner wall section 131 is located between the first columnar wall section 132 and the neck 120, and the connecting hole 150 is provided in the body portion 110 located between the neck 120 and the guide inner wall section 131.

[0031] In this embodiment, the first columnar wall segment 132 is used to prevent the dripped reagent liquid or the initially formed frozen balls from being hung or rested on the wall of the guide channel 130, and to prevent the dripped reagent liquid or the initially formed frozen balls from sticking to the inner guide wall segment 131. Furthermore, the connecting hole 150 is provided in the part of the body 110 between the neck 120 and the inner guide wall segment 131, so that the falling process of the frozen balls can be frozen by the gas of liquid nitrogen vaporization, ensuring the processing quality of the frozen balls.

[0032] According to one embodiment of this application, the depth of the first columnar wall segment 132 is 1 / 2 to 2 / 3 of the depth of the guide channel 130. This allows sufficient time for the reagent solution and liquid nitrogen to cool before the frozen pellet falls onto the guide inner wall segment 131, ensuring that the frozen pellet does not stick to the guide inner wall segment 131.

[0033] In one embodiment, there are several connecting holes 150, and their proportion per unit area is 75% to 85%. When the connecting holes 150 are connected to the guide channel 130 of the guide member 100, the input amount of coolant such as liquid nitrogen is increased, ensuring that the guide channel 130 is filled with sufficient coolant, and that the encapsulation bottle 210 connected to the outlet 140 is filled with freezing pellets, while also filling the encapsulation bottle 210 with liquid nitrogen.

[0034] Please see Figures 1 to 2 In one specific embodiment, there are several connecting holes 150, each of which is rectangular. The connecting holes 150 are evenly arranged in several columns, and each column includes several rows of evenly arranged connecting holes 150. The gap between each adjacent column is equal. In this way, when the input amount of coolant such as liquid nitrogen is increased, it can be ensured that the guide channel 130 is filled with a sufficient amount of coolant.

[0035] In one embodiment, the guide channel 130 includes a plurality of guide inner wall segments 131 arranged along the direction from the inlet 112 to the outlet 140, and the slope of the guide inner wall segments 131 increases sequentially along the direction from the inlet 112 to the outlet 140. A connecting hole 150 is provided in the body portion 110 at the location between the neck 120 and any one of the guide inner wall segments 131.

[0036] Specifically, the slope of the inner guide wall section 131 near the inlet 112 is smaller than that of the inner guide wall section 131 near the outlet 140, that is, the slope of the inner guide wall section 131 near the outlet 140 is larger, and the inclination normal of the inner guide wall section 131 near the outlet 140 is closer to the center line of the guide channel 130; the position of the connecting hole 150 on the body 110: it can be located between the neck 120 and the inner guide wall section 131 near the inlet 112, or it can be located between the neck 120 and the inner guide wall section 131 near the outlet 140.

[0037] By utilizing multiple guide inner wall sections 131, combined with the gravity of the frozen ball, the frozen ball moves along the guide channel 130, ensuring that the frozen ball can fall smoothly towards the outlet 140 and fall into the packaging bottle 210 at the outlet. Furthermore, by utilizing the increasing slope of the guide inner wall sections 131 along the direction from the inlet 112 to the outlet 140, it is ensured that the coolant can roll off the guide inner wall sections 131. Then, by utilizing the connecting hole 150 located in the body 110 between the neck 120 and any one of the guide inner wall sections 131, the falling process of the frozen ball can be frozen by the gas of liquid nitrogen vaporization, ensuring the processing quality of the frozen ball freezing process.

[0038] Please see Figure 2In one specific embodiment, the guide channel 130 further includes at least one second columnar wall segment 133 and at least one conical wall segment, the second columnar wall segment 133 and the conical wall segment being alternately arranged; the inner guide wall segment 131 corresponds to the conical wall segment; along the direction from the inlet 112 to the outlet 140, the slope of the conical wall segment increases sequentially, and the size of the guide channel 130 decreases; one of the conical wall segments is connected to the first columnar wall segment 132; the other conical wall segment is connected to the neck 120; the connecting hole 150 is provided in any one of the second columnar wall segments 133. Further, the conical wall segment is conical in shape, or the conical wall segment is pyramidal in shape; it plays a guiding role for the frozen pellets.

[0039] Specifically, along the direction from inlet 112 to outlet 140, the second columnar wall segment 133 and the conical wall segment are alternately arranged, that is: along the direction from inlet 112 to outlet 140, first a conical wall segment, then a second columnar wall segment 133, and then another conical wall segment, see... Figure 2 .

[0040] It should be noted that as long as the guide channel 130 in the guide member 100 of this application meets the above-mentioned technical features of the guide inner wall section 131, it can guide the frozen pellets to fall smoothly into the packaging bottle 210. As for the appearance and shape of the guide member 100, there are no special requirements.

[0041] However, to avoid the problem of the guide member 100 being bulky and occupying a large amount of space, in some embodiments, in order to save space, please refer to... Figures 1 to 2 The body 110 includes at least two cylindrical segments 113 and at least two conical segments 114, wherein one cylindrical segment 113 is connected to the mounting plate 111; the cylindrical segments 113 and conical segments 114 are arranged alternately at intervals; the hollow spaces of the cylindrical segments 113 and conical segments 114 together form a guide channel 130, wherein each guide inner wall segment 131 corresponds to the inner wall of the conical segment 114, and the first cylindrical wall segment 132 is the inner wall of the cylindrical segment 113 connected to the mounting plate 111; along the direction from the inlet 112 to the outlet 140, the size of the cylindrical segment 113 decreases, and the slope of the guide inner wall segment 131 increases sequentially. This prevents the frozen pellets from adhering to the guide inner wall segment 131.

[0042] Specifically, the slope of the inner guide wall section 131 near the inlet 112 is smaller than that of the inner guide wall section 131 near the outlet 140, that is, the inclination slope of the inner guide wall section 131 near the outlet 140 is greater, and the inclination normal of the inner guide wall section 131 near the outlet 140 is closer to the center line of the guide channel 130; correspondingly, the axial dimension of the cylindrical section 113 near the inlet 112 is smaller than that of the cylindrical section 113 near the outlet 140.

[0043] Because the reagent solution either floats on the surface of the liquid nitrogen or gradually falls towards the outlet 140 during the time it is dripped into the guide channel 130 until it completely forms cryospheres and settles into the outlet 140, it concentrates within the guide channel 130. During this time, a large number of reagent droplets or nascent cryospheres accumulate in the guide channel 130. Unformed cryospheres are prone to sticking together, thus affecting the quality of the cryospheres. Therefore, please refer to... Figure 2 In one embodiment, at least one partition plate 160 is also fixed on the mounting plate 111. Each partition plate 160 is located within the guide channel 130, and the partition plate 160 divides the guide channel 130 into several sub-channels 134. The length of each partition plate 160 is less than the depth of the guide channel 130. Multiple inlets 112 are included, and each inlet is connected to a corresponding sub-channel 134. Multiple frozen pellets are simultaneously introduced using the multiple sub-channels 134 and multiple inlets 112, and the partition plates 160 are used to prevent the frozen pellets from sticking together.

[0044] Specifically, the inlet 112 and the sub-channel 134 are set in a one-to-one correspondence. There are multiple sub-channels 134 and multiple inlets. There can be only one outlet 140. Multiple sub-channels 134 share one outlet 140 to avoid two drops of reagent liquid sticking together before the reagent liquid has completely formed frozen balls. After the reagent liquid has completely formed frozen balls, the frozen balls will not stick together, so they can share one outlet 140 to achieve the output of multiple frozen balls and reduce the material used in the manufacture of the equipment.

[0045] In one specific embodiment, a partition plate 160 is fixed on the mounting plate 111, and the partition plate 160 divides the guide channel 130 into two sub-channels 134, see Figure 2 .

[0046] According to one embodiment of this application, the inner wall of the guide channel 130 is further provided with a coating layer (not shown in the figure). This prevents the frozen pellets from adhering to the guide channel 130 and provides an antibacterial effect. In one specific embodiment, the coating layer is a Teflon layer, which further prevents the frozen pellets from adhering to the guide channel 130 and provides an antibacterial effect.

[0047] The working principle of the guiding component of this application is as follows: A connecting hole 150 is used to fill the guiding channel 130 with a coolant such as liquid nitrogen. A reagent solution introduced through the inlet 112 enters the guiding channel 130, thereby cooling it with the liquid nitrogen or other coolant in the guiding channel 130 and forming frozen spheres. Then, the frozen spheres move along the guiding channel 130 under the action of gravity, and through the guiding action of the inner wall section 131, the frozen spheres fall smoothly towards the outlet 140. A sealing bottle 210 is placed at the outlet 140, allowing the frozen spheres leaking out of the outlet 140 to be guided into the sealing bottle 210.

[0048] This application also provides a bottling device for collecting frozen pellets. The bottling device 200 includes a sealing bottle 210 with a bottle neck 211. The bottling device 200 also includes a guide member 100 as described above. A neck 120 is mounted on the bottle neck 211, and the neck 120 and the bottle neck 211 are in a clearance fit. This allows coolant such as liquid nitrogen to fill the sealing bottle 210, ensures that the processed frozen pellets fall into the sealing bottle 210, and ensures that the sealing bottle 210 and the neck 120 are detachably connected.

[0049] According to one embodiment of this application, the gap between the bottle neck 211 and the neck 120 is smaller than the diameter of the frozen pellets, preferably 0.2 to 0.8 times the diameter of the frozen pellets. This ensures that the processed frozen pellets can fall into the encapsulation bottle 210 but will not flow out from the gap between the bottle neck 211 and the neck 120.

[0050] This application also provides an apparatus for preparing frozen microspheres, including the bottling device 200 in any of the above embodiments.

[0051] The terms "first," "second," and "third" in this application are for descriptive purposes only and should not be construed as indicating the number of technical features indicated. Therefore, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of those features. All directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of this application are only used to explain the relative positional relationships and movements between components in a specific orientation (as shown in the figures). If the specific orientation changes, the directional indications will change accordingly. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. A process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or devices.

[0052] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A guide component for bottling frozen microspheres, characterized in that, The guiding component includes a body, a neck connecting the body, and a guiding channel; The guide channel is disposed inside the body and extends through the neck to form an outlet for discharging the frozen sphere; The body includes a mounting plate located away from the outlet, and the mounting plate has an inlet; The centerline of the guide channel is a straight line, and the inner wall of the guide channel includes a guide inner wall segment that is inclined toward the outlet and toward the centerline of the guide channel. Along the direction perpendicular to the centerline, the cross-sectional dimension of the neck is smaller than the cross-sectional dimension of the body. The body is provided with a connecting hole that connects to the guide channel. The shape formed by any region of the connecting hole is smaller than the cross-section passing through the center of the frozen sphere. The connecting hole is connected to the Dewar flask, so that the coolant in the Dewar flask enters the guide channel.

2. The guiding component according to claim 1, characterized in that, The guide channel includes a first columnar wall segment connected to the mounting plate; the guide inner wall segment is located between the first columnar wall segment and the neck, and the connecting hole is disposed in the body portion located between the neck and the guide inner wall segment.

3. The guiding component according to claim 2, characterized in that, The depth of the first columnar wall segment is 1 / 2 to 2 / 3 of the depth of the guide channel.

4. The guiding component according to claim 2, characterized in that, The number of connecting holes is several, and their proportion per unit area is 75% to 85%.

5. The guiding component according to claim 2, characterized in that, There are several connecting holes, each of which is rectangular. The connecting holes are evenly arranged in several columns, and each column includes several rows of evenly arranged connecting holes. The gap between each adjacent column is equal.

6. The guiding member according to any one of claims 1-5, characterized in that, The guiding channel includes multiple guiding inner wall segments arranged along the direction from the inlet to the outlet, and the slope of the guiding inner wall segments increases sequentially along the direction from the inlet to the outlet. The connecting hole is disposed in the body at a location between the neck and any one of the guiding inner wall segments.

7. The guiding component according to claim 2, characterized in that, The guiding channel further includes at least one second columnar wall segment and at least one conical wall segment, wherein the second columnar wall segment and the conical wall segment are arranged alternately at intervals; The inner wall segment of the guide corresponds to the conical wall segment; Along the direction from the inlet to the outlet, the slope of the conical wall segment increases sequentially, and the size of the guide channel decreases. One of the conical wall segments is connected to the first columnar wall segment; Another of the conical wall segments is connected to the neck; The connecting hole is provided in any one of the second columnar wall segments.

8. The guiding component according to claim 2, characterized in that, The body includes at least two cylindrical sections and at least two conical sections, wherein one of the cylindrical sections is connected to the mounting plate; The cylindrical section and the conical section are arranged alternately at intervals; The hollow sections of the cylindrical section and the conical section together form the guide channel, wherein each guide inner wall section corresponds to the inner wall of the conical section, and the first cylindrical wall section is the inner wall of the cylindrical section connected to the mounting plate. Along the direction from the inlet to the outlet, the size of the cylindrical section decreases, and the slope of the guide inner wall section increases sequentially.

9. The guiding member according to any one of claims 1-5 and 7-8, characterized in that, At least one isolation plate is also fixed on the mounting plate, each isolation plate being located within the guide channel, and the isolation plate dividing the guide channel into several sub-channels; The length of each of the isolation plates is less than the depth of the guide channel; The inlet includes multiple inlets, each of which is connected to a corresponding sub-channel.

10. The guiding member according to any one of claims 1-5 and 7-8, characterized in that, The inner wall of the guide channel is also provided with a coating layer.

11. The guiding member according to claim 10, characterized in that, The coating layer is a Teflon layer.

12. A bottling apparatus for collecting frozen pellets, the bottling apparatus comprising a sealing bottle, the sealing bottle including a bottle neck, characterized in that, The bottling device further includes a guide member as described in any one of claims 1-10; The neck is installed on the bottle mouth, and the neck and the bottle mouth are fitted with a clearance fit.

13. The bottling apparatus according to claim 12, characterized in that, The gap between the bottle opening and the neck is smaller than the diameter of the frozen pellet.

14. An apparatus for preparing frozen microspheres, characterized in that, Includes the bottling apparatus as described in any one of claims 12-13 above.

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